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Researchers at UCD

researcher

Douglas Veale

Adjunct Professor

School Of Medicine & Medical Science
Health Sciences Centre
Belfield
Dublin 4

Tel: +353 1 716
Email: douglas.veale@ucd.ie

Biography

Douglas J. Veale is Director of Translational Research of the DAMC, Professor of Medicine and Consultant Rheumatologist at St Vincent¿s University Hospital and a Principal Investigator at The Conway Institute for Biomedical and Biomolecular Research, University College Dublin (UCD). He is a Fellow of both the Royal College of Physicians in Ireland (1997) and the Royal College, London (1999).  Professor Veale graduated from the Royal College of Surgeons in Ireland in 1984 and obtained his MD by thesis from UCD in 1992.

 

Professor Veale has established an international reputation in translational research in the areas of angiogenesis, early arthritis, biopharmaceutical therapy, biomarkers and scleroderma. He has established an excellent research team including senior scientists, post-doctoral scientists, clinical research fellows and PhD students funded by peer-reviewed grants from The American Federation for Ageing Research, the European Union FP6 programme and Innovative Medicines Initiative (IMI), The Health Research Board of Ireland, Science Foundation Ireland, the Programme for Research in Third Level Institutions and a several of industry partnership programmes.

 

 

Publications

 

Book Chapters

Carr H, Ryan J, Joyce M, Fitzgerald O, Veale D, Gibney R, Brennan ; (2008) 'A Topological Approach to Quantitation of Rheumatoid Arthritis' In: Visualization in Medicine and Life Sciences. Berlin: Lecture Notes in Computer Science, Springer-Verlag. [Details]
 

Peer Reviewed Journals

Pontifex EK, Gerlag DM, Gogarty M, Vinkenoog M, Gibbs A, Burgman I, Fearon U, Bresnihan B, Tak PP, Gibney RG, Veale DJ, Fitzgerald O; (2011) 'Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study'. Arthritis Research & Therapy, . [Details]
Reid A, Brady A, Blake C, Mongey AB, Veale DJ, FitzGerald O, Cusack T; (2011) 'Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication'. BMC Musculoskeletal Disorders, . [Details]
Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, O'Sullivan J; (2011) 'Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis'. Arthritis and Rheumatism, 63 (8):2172-2182. [DOI] [Details]
Connolly M, Veale DJ, Fearon U; (2011) 'Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis'. Annals of the rheumatic diseases, 70 (7):1296-1303. [DOI] [Details]
Veale DJ; (2011) 'New therapies and new goals for psoriatic arthritis'. Arthritis and Rheumatism, 63 (4):874-876. [DOI] [Details]
Adams R, Craig BM, Walsh CD, Veale DJ, Bresnihan B, FitzGerald O, Barry M; (2011) 'The impact of a revised EQ-5D population scoring on preference-based utility scores in an inflammatory arthritis cohort'. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 14 (6):921-927. [DOI] [Details]
de Hair MJ, Harty LC, Gerlag DM, Pitzalis C, Veale DJ, Tak PP; (2011) 'Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis'. The Journal of rheumatology, 38 (9):2068-2072. [DOI] [Details]
Biniecka M, Kennedy A, Ng CT, Chang TC, Balogh E, Fox E, Veale DJ, Fearon U, O'Sullivan JN; (2011) 'Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis'. Arthritis Research & Therapy, 13 (4). [DOI] [Details]
Kennedy, A,Ng, CT,Chang, TC,Biniecka, M,O'Sullivan, JN,Heffernan, E,Fearon, U,Veale, DJ; (2011) 'Tumor Necrosis Factor Blocking Therapy Alters Joint Inflammation and Hypoxia'. Arthritis and Rheumatism, 63 :923-932. [DOI] [Details]
Biniecka, M,Fox, E,Gao, W,Ng, CT,Veale, DJ,Fearon, U,O'Sullivan, J; (2011) 'Hypoxia Induces Mitochondrial Mutagenesis and Dysfunction in Inflammatory Arthritis'. Arthritis and Rheumatism, 63 :2172-2182. [DOI] [Details]
Saber, T,Veale, DJ,Balogh, E,McCormick, J,NicAnUltaigh, S,Connolly, M,Fearon, U; (2011) 'Toll-Like Receptor 2 Induced Angiogenesis and Invasion Is Mediated through the Tie2 Signalling Pathway in Rheumatoid Arthritis'. PLoS ONE, 6 . [DOI] [Details]
Reid A, Brady A, Blake C, Mongey AB, Veale DJ, Filzgerald O, Cusack T.; (2011) 'Randomised controlled trial examining the effect of exercise in people with Rheumatoid Arthritis taking TNFalpha therapy medication'. BMC MUSCULOSKEL DIS, 12 (11). Available Online [DOI] [Details]
Moran EM, Connolly M, Gao W, McCormick J, Fearon U, Veale DJ; (2011) 'Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement'. Arthritis and Rheumatism, 63 (11):3263-3273. [DOI] [Details]
Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, Appel H, Fearon U, Veale DJ; (2011) 'IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates'. PLoS ONE, 6 (8). [DOI] [Details]
Kennedy A, Ng CT, Chang TC, Biniecka M, O'Sullivan JN, Heffernan E, Fearon U, Veale DJ; (2011) 'Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia'. Arthritis and Rheumatism, 63 (4):923-932. [DOI] [Details]
Nic An Ultaigh S, Saber TP, McCormick J, Connolly M, Dellacasagrande J, Keogh B, McCormack W, Reilly M, O'Neill LA, McGuirk P, Fearon U, Veale DJ; (2011) 'Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures'. Arthritis Research & Therapy, 13 (1). [DOI] [Details]
Huang A, Harty LC, Ryan CM, Veale DJ; (2011) 'Clinical images: infliximab therapy of polyarticular small joint sarcoid arthritis'. Arthritis and Rheumatism, 63 (7). [DOI] [Details]
Minnock, P,Kirwan, J,Veale, D,FitzGerald, O,Bresnihan, B; (2010) 'Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis'. Clinical and experimental rheumatology, 28 :401-404. [Details]
Saber, TP,Ng, CT,Renard, G,Lynch, BM,Pontifex, E,Walsh, CAE,Grier, A,Molloy, M,Bresnihan, B,FitzGerald, O,Fearon, U,Veale, DJ; (2010) 'Remission in psoriatic arthritis: is it possible and how can it be predicted?'. Arthritis Research & Therapy, 12 . [DOI] [Details]
Adams R, Walsh C, Veale D, Bresnihan B, FitzGerald O, Barry M; (2010) 'Understanding the relationship between the EQ-5D, SF-6D, HAQ and disease activity in inflammatory arthritis'. . [Details]
Minnock P, Kirwan J, Veale D, Fitzgerald O, Bresnihan B; (2010) 'Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis'. Clinical and Experimental Rheumatology, . [Details]
Connolly, M,Marrelli, A,Blades, M,McCormick, J,Maderna, P,Godson, C,Mullan, R,FitzGerald, O,Bresnihan, B,Pitzalis, C,Veale, DJ,Fearon, U; (2010) 'Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model'. J IMMUNOL, 184 :6427-6437. [DOI] [Details]
Martin, J,Walsh, C,Gibbs, A,McDonnell, T,Fearon, U,Keane, J,Codd, MB,Dodd, J,Veale, D,FitzGerald, O,Bresnihan, B; (2010) 'Comparison of interferon gamma release assays and conventional screening tests before tumour necrosis factor alpha blockade in patients with inflammatory arthritis'. Annals of Rheumatic Diseases, 69 :181-185. [DOI] [Details]
Kennedy A, Ng CT, Biniecka M, Saber J, Taylor C, O¿Sullivan J, Veale DJ, Fearon U.; (2010) 'Angiogenesis and Blood Vessel Stability in Inflammatory Synovial Tissue'. Arthritis and Rheumatism, 62 (3):711-721. [Details]
Ng CT, Radovits BJ, Kievit W, Fransen J, van Riel PL, FitzGerald O, Veale DJ, Bresnihan B.; (2010) 'Unregulated prescribing of anti-tumour necrosis factor agents does not mean inappropriate prescribing'. Annals of Rheumatic Diseases, . [Details]
Ng CT, Biniecka, M., Kennedy, A., McCormick, K., FitzGerald, O., Bresnihan, B., Buggy, D., Taylor,C.T., O'Sullivan, J., Fearon, U., and Veale, D.J:; (2010) 'Synovial Tissue Hypoxia and Inflammation in vivo'. Annals of Rheumatic Diseases, 69 (7):1389-1395. [Details]
Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Babalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP; (2009) 'Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers'. Journal of Rheumatology, . [Details]
Oliver, KM,Garvey, JF,Ng, CT,Veale, DJ,Fearon, U,Cummins, EP,Taylor, CT; (2009) 'Hypoxia Activates NF-kappa B-Dependent Gene Expression Through the Canonical Signaling Pathway'. Antioxidants & Redox Signaling, 11 :2057-2064. [DOI] [Details]
Pearman, L,Last, J,Fitzgerald, O,Veale, D,Joyce, M,Rainford, L,Mcentee, M,Mcnulty, J,Thomas, E,Ryan, J,Mcgee, A,Toomey, R,D'Helft, C,Lowe, J,Brennan, PC; (2009) 'Rheumatoid arthritis: a novel radiographic projection for hand assessment'. British Journal of Radiology, 82 :554-560. Available Online [DOI] [Details]
Doran JP, Alraqi S, Callanan I, Fitzgerald O, Bresnihan B, Veale DJ; (2009) 'An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions'. IRISH JOURNAL OF MEDICAL SCIENCE, . [Details]
Martin J, Walsh C, Gibbs A, McDonnell T, Fearon U, Keane J, Codd MB, Dodd JD, Veale D, Fitzgerald O, Bresnihan B; (2009) 'Comparison of interferon-{gamma}-release assays and conventional screening tests before tumour necrosis factor-{alpha} blockade in patients with inflammatory arthritis'. Annals of Rheumatic Diseases, . [Details]
Rooney T, Roux-Lombard P, Veale DJ, Fitzgerald O, Dayer JM, Bresnihan B; (2009) 'Synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression. analysis of a proof-of-concept randomized clinical trial of cytokine blockade'. Annals of Rheumatic Diseases, . [Details]
Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U; (2009) 'Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis'. Arthritis Research and Therapy, . [Details]
Brennan PC, Pearman L, Last J, Fitzgerald O, Veale D, Joyce M, Rainford L, McEntee M, McNulty J, Thomas E, Ryan J, McGee A, Toomey D'Helft R, Lowe J, ; (2009) 'Rheumatoid arthritis: a novel radiographic projection for hand assessment'. British Journal of Radiology, (NA). [DOI] [Details]
Rooney T, Edwards CK 3rd, Gogarty M, Greenan L, Veale DJ, Fitzgerald O, Dayer JM, Bresnihan B; (2009) 'Synovial tissue rank ligand expression and radiographic progression in rheumatoid arthritis: observations from a proof-of-concept randomized clinical trial of cytokine blockade'. Rheumatology International, . [Details]
O'Kane, M,Markham, T,McEvoy, AN,Fearon, U,Veale, DJ,FitzGerald, O,Kirby, B,Murphy, EP; (2008) 'Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition'. J Invest Dermatol, 128 :300-310. [DOI] [Details]
Walsh CA, Fearon U, Fitzgerald O, Veale DJ, Bresnihan B.; (2008) 'Decreased CD20 expression in rheumatoid arthritis synovium following eight weeks of rituximab therapy'. Clinical and Experimental Rheumatology, . [Details]
Brulhart, L., Ng, C. T., Codd, M. B., Walsh, C. A. E., Pontifex, E. K., Lynch, B., Grier, A., Molloy, M., O'Flynn, E., Bresnihan, B., FitzGerald, O., Veale, D. J., ; (2007) 'Co-medication with methotrexate is not associated with remission in psoriatic arthritis patients on TNFI inhibitors treatment'. Arthritis and Rheumatism, 56 (12):4298-4299. [Details]
Mullan, RH; Fearon, U; Mathews, C; Lobanok, T; King, L; FitzGerald, O; Bresnihan, B; Poole, R; Veale, DJ; ; (2006) 'Serum amyloids a (A-SAA) correlates with joint damage in vivo and induces cartilage matrix degradation in vitro'. Arthritis and Rheumatism, 54 (9):595-596. [Details]
Pontifex, E; Gogarty, M; Murphy, E; Bresnihan, B; Veale, D; FitzGerald, O; ; (2006) 'JunB expression in psoriatic arthritis synovium and skin pre- and post-treatment with etanercept'. Arthritis and Rheumatism, 54 (9):466-466. [Details]
Veale DJ; (2010) 'What can we learn from negative clinical trials in systemic sclerosis?'. Clinical and experimental rheumatology, 28 (2 Suppl 58):1-4. [Details]
Harty L, Veale DJ; (2010) 'How early should psoriatic arthritis be treated with a TNF-blocker?'. Current Opinion in Rheumatology, 22 (4):393-396. [DOI] [Details]
Tobin AM, Veale DJ, Fitzgerald O, Rogers S, Collins P, O'Shea D, Kirby B; (2010) 'Cardiovascular disease and risk factors in patients with psoriasis and psoriatic arthritis'. The Journal of rheumatology, 37 (7):1386-1394. [DOI] [Details]
Saber TP, Ng CT, Renard G, Lynch BM, Pontifex E, Walsh CA, Grier A, Molloy M, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ; (2010) 'Remission in psoriatic arthritis: is it possible and how can it be predicted?'. Arthritis Research & Therapy, 12 (3). [DOI] [Details]
Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U; (2010) 'A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A'. Journal of Pathology, 176 (4):1999-2008. [DOI] [Details]
Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U; (2010) 'Angiogenesis and blood vessel stability in inflammatory arthritis'. Arthritis and Rheumatism, 62 (3):711-721. [DOI] [Details]
Rooney T, Edwards CK 3rd, Gogarty M, Greenan L, Veale DJ, FitzGerald O, Dayer JM, Bresnihan B; (2010) 'Synovial tissue rank ligand expression and radiographic progression in rheumatoid arthritis: observations from a proof-of-concept randomized clinical trial of cytokine blockade'. Rheumatology international, 30 (12):1571-1580. [DOI] [Details]
Biniecka M, Kennedy A, Fearon U, Ng CT, Veale DJ, O'Sullivan JN; (2010) 'Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint'. Annals of the rheumatic diseases, 69 (6):1172-1178. [DOI] [Details]
Rooney T, Roux-Lombard P, Veale DJ, FitzGerald O, Dayer JM, Bresnihan B; (2010) 'Synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression: analysis of a proof-of-concept randomised clinical trial of cytokine blockade'. Annals of the rheumatic diseases, 69 (4):706-714. [DOI] [Details]
Englbrecht M, Wang Y, Ronneberger M, Manger B, Vastesaeger N, Veale DJ, Schett G; (2010) 'Measuring joint involvement in polyarticular psoriatic arthritis: an introduction of alternatives'. Arthritis care & research, 62 (7):977-983. [DOI] [Details]
Harty LC, Veale DJ; (2010) 'Irish smokers with rheumatoid arthritis suffer more than their nonsmoking counterparts'. The Journal of rheumatology, 37 (5). [DOI] [Details]
Saber TP, Veale DJ; (2009) 'Psoriatic arthritis management update - biotherapeutic options'. The Journal of rheumatology, 83 :65-68. [DOI] [Details]
Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U; (2009) 'Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies'. Arthritis Research & Therapy, 11 (4). [DOI] [Details]
Oliver KM, Garvey JF, Ng CT, Veale DJ, Fearon U, Cummins EP, Taylor CT; (2009) 'Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway'. Antioxidants & Redox Signaling, 11 (9):2057-2064. [DOI] [Details]
Doran JP, Alraqi S, Callanan I, Fitzgerald O, Bresnihan B, Veale DJ; (2009) 'An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions'. Journal Of Medicine, . [DOI] [Details]
Ng CT, O'Neil M, Walsh D, Walsh T, Veale DJ; (2008) 'Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation failures and anti-phospholipid antibody positive'. Journal Of Medicine, . [DOI] [Details]
Veale DJ, Woolf AD, Carr AJ; (2008) 'Chronic musculoskeletal pain and arthritis: impact, attitudes and perceptions'. Irish medical journal, 101 (7):208-210. [Details]
Smith MD, Baeten D, Ulfgren AK, McInnes IB, Fitzgerald O, Bresnihan B, Tak PP, Veale D; (2006) 'OMERACT synovial special interests group. Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go?'. Annals of Rheumatic Diseases, 65 (1):93-100. [Details]
Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'hara R, Fitzgerald O, Veale DJ, Fearon U. ; (2006) 'Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway'. Arthritis and Rheumatism, 54 (1):105-114. [Details]
Karim Z, Wakefield RJ, Quinn M, Conaghan PG, Brown AK, Veale DJ, Connor PO, Reece R, Emery P. ; (2004) 'Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: A comparison with arthroscopy and clinical examination'. Arthritis and Rheumatism, 50 (2):387-394. [Details]
Woolf AD, Zeidler H, Haglund U, Carr AJ, Chaussade S, Cucinotta D, Veale DJ, Martin-Mola E. ; (2004) 'Musculoskeletal pain in Europe: its impact and a comparison of population and medical perceptions of treatment in eight European countries'. Annals of Rheumatic Diseases, 63 (4):342-347. [Details]
Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ. ; (2003) 'Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation'. Arthritis and Rheumatism, 48 (11):3085-3095. [Details]
Fearon U, Griosios K, Fraser A, Reece R, Emery P, Jones PF, Veale DJ. ; (2003) 'Angiopoietins, growth factors, and vascular morphology in early arthritis'. Journal of Rheumatology, 30 (2):260-268. [Details]
Ali M, Ponchel F, Wilson KE, Francis MJ, Wu X, Verhoef A, Boylston AW, Veale DJ, Emery P, Markham AF, Lamb JR, Isaacs JD. ; (2001) 'Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy'. Journal of Clinical Investigation, 107 (4):519-528. [Details]
Fraser A, Fearon U, Reece R, Emery P, Veale DJ. ; (2001) 'Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis'. Arthritis and Rheumatism, 44 (9):2024-2028. [Details]
Veale DJ, Reece RJ, Parsons W, Radjenovic A, O'Connor PJ, Orgles CS, Berry E, Ridgway JP, Mason U, Boylston AW, Gibbon W, Emery P. ; (1999) 'Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology'. Annals of Rheumatic Diseases, 58 (6):342-349. [Details]
Reece RJ, Canete JD, Parsons WJ, Emery P, Veale DJ. ; (1999) 'Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis'. Arthritis and Rheumatism, 42 (7):1481-1484. [Details]

Other Journals

Smith, M.D., Baeten, D., Ulfgren, A.K., McInnes, FitzGerald, O., Bresnihan, B., Tak, P.P. Veale, D.; (2006) 'Standardisation of synovial tissue infiltrate analysis: how far have we come? How much farther do we need to go? OMERACT 7 synovial special interest group: Review' Annals of the Rheumatic Diseases . [Details]
Markham, T., Mullan, R., Golden-Mason, L., Rogers, S., Bresnihan, B., FitzGerald, O., Fearon, U. Veale, D.J.; (2005) 'Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy' J Am Acad Dermatol . [Details]
Bresnihan, B., Baeten, D., Firestein, G.S., FitzGerald, O.M., Gerlag, D.M., Haringman, J.J., McInnes, I.B., Reece, R.J., Smith, M.D., Ulfgren, A.K., Veale, D.J. Tak, P.P.; (2005) 'Synovial tissue analysis in clinical trials: OMERACT 7 Special Interest Group: Review' Journal of Rheumatology . [Details]

Conference Publications

Gogarty, M., Murphy, E.P., Veale, D., Bresnihan, B., FitzGerald, O.; Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis ARTHRITIS AND RHEUMATISM [Details]
Reid A., Brady A., Mongey A., Veale D.J., FitzGerald O., Blake C., Cusack T.; (2011) EFFECT OF DYNAMIC EXERCISE ON FUNCTION IN PEOPLE WITH RHEUMATOID ARTHRITIS TAKING ANTI-TNF MEDICATION: RESULTS OF A RCT World Confederation for Physical Therapy Amsterdam, , 20-JUN-11 - 23-JUN-11 [Details]
Ryan J, NG CT, Gibney R, Fitzgerald O, Brennan P, Hefferenan E, Fearon U, McNulty J, Rainford L, Veale D; (2010) Novel PET/MR Fusion Imaging and Quantification of Knee Synovitis in Rheumatoid Arthritis American College of Rheumatology Annual Scientific Meeting Atlanta, USA, Available Online [Details]
Reid A, Brady A, Cusack T, Blake C, Monget AB, Veale D, FitzGerald O.; (2010) Improvements in Function Following Dynamic Exercise in Patients with RA taking anti-TNFα Therapy Reflected in Lower Limb Function Tests but not the HAQ American College of Rheumatologists Atlanta, USA, , 08-NOV-10 - 13-NOV-10 [Details]
O'Kane, M., Markham, T., McEvoy, A. N., Fearon, U., Veale, D. J., FitzGerald, O., Kirby, B., Murphy, E. P., ; (2008) Journal of Investigative Dermatology Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition , pp.300-310 [Details]
Garraud C, Ryan J, Carr H, Gibney R, Veale D, Fitzgerald O, Brennan PC; (2007) A volumetric reconstruction method for semi-automatic quantification of rheumatoid arthritis within the knee Virtual Reality Interactions and Physical Simulations [Details]
Gogarty, M, Murphy, EP, Fearon, U, Veale, DJ, Bresnihan, B, FitzGerald, O, ; (2007) ANN RHEUM DIS Placenta growth factor (PLGF) expression in inflammatory arthritis , pp.35-36 [Details]
Gogarty, M., Murphy, E. P., Fearon, U., Veale, D. J., Bresnihan, B., FitzGerald, O., ; (2007) Annals of the Rheumatic Diseases Abundant placenta growth factor (PlGF) expression in the inflammatory joint , pp.141-141 [Details]
Mullan, R., Bresnihan, B., Sweeney, C., Connolly, M., FitzGerald, O., Veale, D. Fearon, U.; (2005) A novel role for the HDL receptor CLA-1 in synovial inflammation through serum amyloid A and apoprotein A-1 American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Mullan, R., Mathews, C., Lobanok, T., Kind, L., Walsh, C., FitzGerald, O., Bresnihan, B., Fearon, U., Poole, R. Veale, D.; (2005) Serum type II collagen epitope measurement predicts radiographic progression during treatment with anti-TNF alpha therapy American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Rooeny, T., Roux-Lombard, P., Veale, D.J., FitzGerald, O., Dayer, J.-M. Bresnihan, B.; (2005) Serum biomarkers of disease activity and radiographic progression in patients receiving biologic therapies for rheumatoid arthritis American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Martin, J., FitzGerald, O., Veale, D., McDonnell, T. Bresnihan, B.; (2005) Screening for latent tuberculosis infection prior to anti-TNF alpha treatment American Colelge of Rheumatology AGM [Details]
O'Rourke, M., FitzGerald, O., Bresnihan, B., Rogers-Gray, B., Winstone, J.M., Buchan, S. Veale, D.; (2005) Infliximab use in psoriatic arthritis : Clinical effectivemess and impact on quality of life American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Walsh, C., O'Farrelly, C., Golden-Mason, L., Veale, D., FitzGerald, O., Bresnihan, B. Veale, D.; (2005) Expansion of T cells expressing CD94/NKG2A in patients with rheumatoid arthritis in clinical remission following treatment with anti-TNF alpha agents American Colelge of Rheumatology AGM [Details]
Sweeney, C., Cahill, P.A., Mullan, R., Connolly, M., Bresnihan, B., FitzGerald, O., Fearon, U. Veale, D.J.; (2005) A role for the survivin and notch signalling pathways in blood vessel maturation and synovial hyperplasia in RA American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Connolly, M., Mullan, R., Sweeney, C., FitzGerald, O., Bresnihan, B., Veale, D.J. Fearon, U.; (2005) A-SAA induces chemokine expression, cell invasion and cytoskeletal disassembly in RA synovial tissue in part through P13 kinase pathway American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Greenan, L., Rooney, T., FitzGerald, Veale, D., Fearon, U. Bresnihan, B.; (2005) Characterisation of RA synovial membrane and synovial fibroblasts before and following anti-cytokine therapy American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Gogarty, M., Murphy, E.P., Veale, D., Bresnihan, B., FitzGerald, O.; (2005) Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis ARTHRITIS AND RHEUMATISM [Details]
Gogarty, M., Murphy, E., Veale, D.J., Bresnihan, B. FitzGerald, O.; (2005) Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis American Colelge of Rheumatology AGM [Details]
Gibbs, A., FitzGerald, O., Bresnihan, B. Veale, D.; (2005) A review of the use of magnetic resonance imaging (MRI) to diagnose spondylarthropathy early American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
Gibbs, A., Markham, T., Walsh, C., Bresnihan, B., Veale, D. FitzGerald.; (2005) Anakinra (Kineret) in psoriasis and psoriatic arthritis: a single centre, open label pilot study American Colelge of Rheumatology AGM , 12-NOV-05 - 17-NOV-05 [Details]
   

Editorial

Veale, DJ; (2011) New Therapies and New Goals for Psoriatic Arthritis. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

The clinical research focus of our group is early inflammatory arthritis - RA, psoriatic arthritis and related psoriasis. The unit has an international reputation for studies based on well-defined inflammatory arthritis cohorts. The translational research focus is on angiogenesis and vascular biology, in collaboration with Ursula Fearon, Jacintha O'Sullivan and Cormac Taylor we have recently attracted a HRB Translational award to examine the role of hypoxia on joint inflammation, mitochondrial bioenergetics, tissue perfusion and genomic instability. The group has combined high-quality clinical cohort studies with novel arthroscopic and high-end imaging technologies to study synovial tissue in vivo macroscopically, ex vivo and at the cellular and molecular level. Recent publications focus on the regulation of angiogenesis by growth factors and cytokines, the effect of novel TNF targetted therapy and novel studies examining the relationship of biomarkers with clinical and imaging measures such as dynamic contrast-enhanced magnetic resonance imaging (DEMRI).

FUNDING AGENCIES:
Cambridge Antibody Technology
EU Autocure Consortium
Heath Research Board
SFI
HRB Fellowship
Industry Sponsor (GSK)
MRC
Raynaud's Scleroderma Association