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Researchers at UCD

Helen Gallagher

Senior Lecturer

School Of Medicine & Medical Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166726
Email: helen.gallagher@ucd.ie

Professional

Honours and Awards

Year: 2009.
Title: First (Foundation) Scholar in Pharmacy
Year: 2010.
Title: Cochrane Fellowship
Year: 2001.
Title: HRB/RIA Watts medal compeition
Year: 2001.
Title: JMS Doctor Awards
Year: 2002.
Title: JMS Doctor Awards
Year: 1997.
Title: Lundbeck Medal

Associations

Association: Pharmaceutical Society of Ireland, Function/Role: Member (Pharmacist)
Association: Society for Neuroscience, Function/Role: *

Patents

Patent 03/066056 A1 : Neuronal growth promoting properties of 5HT-6 antagonists.
Patent 2000 01871 : Teratogenesis assay
Patent 03394043.8 : Use of protein kinase C delta inhibtors for upregulating NCAM PSA.
     

Committees

Committee : National University of Ireland - Senate
Committee : SMMS Medicine Degrees Committee 2 (Graduate Entry Medicine)
Committee : SMMS PhD Transfer SubCommittee
Committee : SMMS Biomedical Research Degree Committee
Committee : UCD Conway Institute Seminar Committee
Committee : SMMS Medicine Degrees Committee 1
Committee : SMMS Biomedical Sciences Section Committee
 

Education

Year 2011 Institution: University College Dublin
Qualification: BSc(Pharm) Subject:
Year 2012 Institution:
Qualification: Other Subject:
Year 1998 Institution:
Qualification: PhD Subject:
Year 1995 Institution: University College Dublin
Qualification: BSc Subject:
         

Publications

 

Book Chapters

Gallagher HC, Murray PT (2014) 'Drug Dosing in Continuous Renal Replacement Therapy' In: Magee C, Tucker K, Singh A (eds). Current Concepts in Dialysis and Continuous Therapies. New York, USA: Springer. [Details]
Murphy K.J., Gallagher H.C. and Regan C.M.; (2002) 'Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period' In: In: Eds. Wilson S.H. and Suk W.A. Lewis Publishers, CRC Press (eds). Biomarkers of Environmentally associated Disease: Technologies, Concepts, and Perspectives. , pp.211-224 [Details]
Regan C, de Souza I, Gallagher H; (2004) 'The impact of chemical residues: the case of polychlorinated biphenyls (PCBs)' In: Regan C, de Souza I, Gallagher H; (eds). Pesticide, Veterinary and other residues in food. Cambridge: Woodhead Publishing Ltd. [Details]
 

Peer Reviewed Journals

Gallagher, HC; (2010) 'New fitness-to-practice requirements for pharmacists in Ireland: Implications for undergraduate pharmacy education'. Medical Teacher, 32 :71-77. [DOI] [Details]
Elsaigh I, Montgomery T, Moriarty DC, Buggy D, Gallagher HC (2011) 'Cell cycle protein expression as a marker of anaesthetic-induced developmental toxicity'. European Journal of Anaesthesiology, 28 . [Details]
Jaura A, Buggy D, Gallagher H (2013) 'The influence of anaesthetic technique on apoptosis in ER negative breast cancer cells'. European Journal of Anaesthesiology, 30 :145-145. [Details]
Ni Mhathuna A, Valchev G, Ash S, Buggy DJ, Gallagher HC (2013) 'The anaesthetic gases, xenon and sevoflurane, have opposing effects on breast cancer cell migration in vitro'. Irish Journal of Medical Science, 182 :S504-S505. [Details]
Gallagher H.C. (2013) 'Addressing the issue of chronic, inappropriate benzodiazepine use: How can pharmacists play a role?'. Pharmacy, 1 (2):65-93. [DOI] [Details]
Ash SA, Valchev GI, Looney M, Ni Mhathuna A, Crowley PD, Gallagher HC, Buggy DJ (2014) 'Xenon decreases cell migration and secretion of a pro-angiogenesis factor in breast adenocarcinoma cells: comparison with sevoflurane'. British journal of anaesthesia, 113 Suppl 1 :14-21. [DOI] [Details]
Crowley PD, Gallagher HC (2014) 'Clotrimazole as a pharmaceutical: past, present and future'. Journal of Applied Microbiology, 117 (3):611-617. [DOI] [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2014) 'Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study'. British journal of anaesthesia, 113 Suppl 1 :1-7. [DOI] [Details]
Ash SA, Valchev GI, Crowley P, Gallagher H, Buggy DJ (2014) 'Xenon and breast cancer cell function in vitro'. European Journal of Anaesthesiology, 31 . [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2013) 'Serum from patients administered distinct anaesthetic techniques has differential effects on apoptosis in ER negative breast cancer cells in vitro'. British journal of anaesthesia, 111 (5):856-857. [Details]
Gallagher H.C., Gallagher R.M., Butler M, Buggy D.J., Henman M.C. (2014) 'Venlafaxine for neuropathic pain (Protocol)'. Cochrane Database of Systematic Reviews, . Available Online [DOI] [Details]
Gallagher RM, Gallagher HC; (2012) 'Improving the working relationship between doctors and pharmacists: is inter-professional education the answer?'. Advances in Health Sciences Education, 17 :247-257. [DOI] [Details]
Gallagher HC; (2010) 'New fitness-to-practice requirements for pharmacists in Ireland: Implications for undergraduate pharmacy education'. Medical Teacher, 32 (2):e71-e77. Available Online [Details]
Regan CM, Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Walsh FS, Hunter AJ, ; (2008) 'The selective 5-HT(6) receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats'. Neuropharmacology, 8 (NA):1166-1174. [DOI] [Details]
Bacon, C.L., Gallagher, H.C., Haughey, J.C., and Regan, C.M.; (2002) 'The anti-proliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase'. Journal of Neurochemistry, 83 :12-19. [Details]
Regan CM, Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, ; (2009) 'Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats'. Biochemical Pharmacology, 77 (7):1254-1265. [DOI] [Details]
Rohan, D,Buggy, DJ,Crowley, S,Ling, FKH,Gallagher, H,Regan, C,Moriarty, DC; (2005) 'Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly'. Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie, 52 :137-142. [Details]
Regan CM, Gallagher HC, Bacon CL, Odumeru OA, Gallagher KF, Fitzpatrick T, ; (2004) 'Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression'. Neurotoxicology and Teratology, 26 (1):73-81. [DOI] [Details]
Foley, AG; Gallagher, HC; Murphy, KJ; Regan, CM; ; (2004) 'Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat'. Neurobiology of Aging, 25 (4):539-546. [Details]
Foley, AG; Murphy, KJ; Hirst, WD; Gallagher, HC; Hagan, JJ; Upton, N; Walsh, FS; Regan, CM; ; (2004) 'The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats'. Neuropsychopharmacology, 29 (1):93-100. [Details]
O' Loinsigh ED, Gherardini LM, Gallagher HC, Foley AG, Murphy KJ, Regan CM; (2004) 'Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro'. Journal of neurochemistry, 88 :370-379. [Details]
Gallagher, HC, O'Reilly, E, Carroll, E, ; (2004) 'Role of D-type cyclin function in neuroblastorna invasiveness'. Molecular Biology of the Cell, 15 (NA):368-368. [Details]
Walmod, P.S., Berezin, A., Gallagher, H.C., Gravemann, U., Lepekhin, E.A., Belman, V., Nau, H., Regan, C.M., Berezin, V., and Bock, E.; (2002) 'Automated in vitro screening of teratogens'. Toxicology and Applied Pharmacology, 181 :1-15. [Details]
Murphy, KJ; Fox, GB; Foley, AG; Gallagher, HC; O'Connell, A; Griffin, AM; Nau, H; Regan, CM; ; (2001) 'Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe'. Neurochemistry, 78 (4):704-714. [Details]
Haughey, J., Bacon, C.L., Gallagher, H.C., and Regan, C.M.; (2001) 'Modulations of cyclin protein expression during the C6 glioma G1 phase by the anticonvulsant valproate'. British Journal of Pharmacology, 134 . [Details]
Gallagher HC, Odumeru OA, Regan CM; (2000) 'Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta'. Journal of Neuroscience Research, 61 :636-645. [Details]
Fox G.B., Fichera G, Barry T, O'Connell A.W., Murphy K.J., Gallagher H.C. and Regan C.M.; (2000) 'Consolidation of passive avoidance learning is associated with transient increases of polysialylated neurons in layer II of the rat medial temporal cortex'. Journal of Neurobiology, 45 :135-141. [Details]
Foley AG, Hartz BP, Gallagher HC, Rønn LCB, Berezin V, Bock E, Regan CM; (2000) 'A synthetic peptide ligand of NCAM Ig1 domain prevents NCAM internalization and disrupts passive avoidance learning'. Journal of neurochemistry, 74 :2607-2613. [Details]
Foley, AG; Murphy, KJ; Hirst, WD; Gallagher, HC; Hagan, JJ; Upton, N; Walsh, FS; Regan, CM; ; (2004) 'The 5-HT6 antagonists SB-271046 and SB-399885 increase basal and learning induced hippocampal ncam-polysialylation'. International Journal of Neuropsychopharmacology, 7 (NA):215-215. [Details]
OConnell, A.W., Fox, G.B., Kjøller, C., Gallagher, H.C., Murphy, K.J., Kelly, J., and Regan, C.M.; (2001) 'Anti-ischemic and cognition-enhancing properties of NNC-711, a GABA reuptake inhibitor'. European Journal of Pharmacology, 424 :37-44. [Details]
Gallagher, H.C., Murphy, K.J., Foley, A.G. and Regan, C.M.; (2001) 'Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain'. Neurochemistry, 77 :425-434. [Details]
O'Connell C., H.C. Gallagher, A. O'Malley, M. Bourke, C.M. Regan; (2001) 'CREB phosphorylation coincides with transient synapse formation in the rat hippocampal dentate gyrus following avoidance learning'. Neural Plasticity, :279-289. [Details]
Soares, S; Gallagher, HC; Gallagher, K; Regan, CM; Nothias, F; ; (2000) 'Correlation between expression of 14-3-3E and NCAM polysialylation in the hypothalamo-neurohypophysial system during lactation'. European Journal of Neuroscience, 12 (NA):274-274. [Details]
O'Leary, G; Bacon, CL; Odumeru, O; Fagan, C; Fitzpatrick, T; Gallagher, HC; Moriarty, DC; Regan, CM; ; (2000) 'Antiproliferative actions of inhalational anesthetics: comparisons to the valproate teratogen'. International Journal of Developmental Neuroscience, 18 (1):39-45. [Details]
 

Conference Publications

Gallagher HC (2013) Medication reviews by pharmacists as a means of reducing medication errors and improving patient outcomes: Current challenges and opportunities International Summit on Clinical Pharmacy & Dispensing Available Online [Details]
Ash SA, Valchev GI, Looney M, Ni Mhathuna A, Crowley PD, Gallagher HC, Buggy DJ (2014) Xenon and sevoflurane effects on migration and expression of angiogenesis factors in breast adenocarcinoma cells in vitro The College of Anaesthetists of Ireland: Delaney Medal Competition 2014 College of Anaesthetists of Ireland, Dublin, Ireland [Details]
Gallagher HC, Clyne M (2014) Evaluation of the PhD Transfer Assessment Process in the UCD School of Medicine and Medical Science, University College Dublin, IRELAND 9th Orpheus Conference on PhD Education in Europe Available Online [Details]
El-Saigh I, Buggy DJ, Gallagher H. (2011) A novel in vitro method for predicting anesthetic-induced developmental toxicity American Society Anesthsiologists Congress Oct 2011, Chicago: Anesthesiology 2011 Chicago, [Details]
El-Saigh I, Buggy DJ, Gallagher H. (2011) Cyclin D3 and predicting anaesthetic toxicity European Society Anaesthesiologists Congress, Amsterdam June 2011, European Journal Anaesthesiologists, 2011 Amsterdam, [Details]
Gallagher HC (2012) PhD education for clinician scientists in Irish medical schools (National Report) 7h Orpheus Conference on PhD Education in Europe [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2013) Serum from patients administered distinct anaesthetic techniques has differential effects on apoptosis in ER negative breast cancer cells in vitro Delaney Medal Competition, The College of Anaesthetists of Ireland [Details]
Gallagher HC (2013) Postgraduate medical education in Ireland, A National Report 8th Orpheus Conference on PhD Education in Europe [Details]
Gallagher, HC; (2010) Doctoral-level education in the six Irish medical schools Orpheus Conference on PhD Education in Europe [Details]
Gallagher HC, Clyne M, Shields DC and O'Connor C; (2009) Thematic PhD programmes at the UCD School of Medicine and Medical Science, Dublin, Ireland Orpheus Conference on PhD Education in Europe [Details]
Gallagher HC; (2008) Multiple mechanisms of action and pharmacological activities of valproate Ehrlich II World Conference on Magic Bullets Nuremberg, Germany, [Details]
Gallagher HC ; (2008) Validation of a novel in vitro assay for the detection of developmental toxicants Keystone Conference on Signalling Pathways in Cancer & Development Steamboat, CO, USA, [Details]
Gallagher HC; (2007) An introduction to DNA methyltransferase inhibitors DMMC International Workshop, Epigenetics: From Mechansisms to Medicines Dublin, Ireland, [Details]
McNamara S, Barrett F, O'Reilly E, Carroll E, Gallagher HC ; (2006) Cell Cycle Signaling Proteins Regulate Invasion and Resistance to Differentiation in Human Neuroblastoma Cell Lines Irish Association for Cancer Research & ISMO Joint Cancer Research Meeting [Details]
O'Farrell, R.; Buggy, D.; Foley, A.; Gallagher, H.; Moriarty, D.; Regan, C ; (2006) Susceptibility of the developing brain to neuronal damage induced by clinical anaesthetic agents European Society of Anesthesiology [Details]
Gallagher HC, Gherardini LM, Gallagher K, Cooper S, Carroll E, O'Reailly E, McNamara S, Barrett F; (2007) Cell cycle proteomics - a systematic approach Keystone Conference on Cell Signaling and Proteomics [Details]
                       

Abstract

Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N., Walsh F.S. and Regan C.M.; (2004) The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Abstract [Details]
Regan C.M., Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N. and Walsh F.S.; (2003) The 5-HT6 receptor antagonists SB-271046 and SB-399885 increase basal and learning induced NCAM-polysialylation in the rat dentate gyrus. Abstract [Details]
Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N., Walsh F.S. and Regan C.M.; (2003) The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Abstract [Details]
                                                               

Research

Research Interests

Pharmaceutical care and practice of pharmacy.

Development of in vitro screening systems for detection of teratogen and endocrine disrupting activities.

Signalling mechanisms regulating neuroplastic events in the central nervous system.

Mechanisms of anaesthetic-induced cytotoxicity.

Research Projects

Sponsor : L'Air Liquide
Title : Influence of xenon gas on breast cancer cell viability and metastasis.
Start Date / End Date : 12-DEC-11 / 31-DEC-16
Sponsor : University College Dublin (UCD)
Title : School Funded Research Account
Start Date / End Date : 01-JUL-14 / 30-JUN-17
Sponsor : L'Air Liquide
Title : Influence of xenon gas on breast cancer metastasis, recurrence and survival in vivo.
Start Date / End Date : 19-SEP-14 / 18-MAR-16
Sponsor : Health Research Board (HRB)
Title : Pharmaceuticals policies: Policies that determine which drugs are reimbursed
Start Date / End Date : 01-DEC-10 / 30-NOV-12
Sponsor : University College Dublin (UCD)
Title : A new application of the in vitro DevTox assay in predicting the in vivo developmental toxicity of anaesthetic agents.
Start Date / End Date : 03-AUG-09 / 31-JAN-11
Sponsor : Enterprise Ireland (EI)
Title : Towards the Replacement of Repeated Dose Systemic Toxicity Testing in Human Safety Assessment
Start Date / End Date : 30-AUG-09 / 30-NOV-09
Sponsor : Enterprise Ireland (EI)
Title : A novel assay for the detection of developmental toxicants (DevTox).
Start Date / End Date : 01-OCT-08 / 07-DEC-09
Sponsor : Enterprise Ireland (EI)
Title : Investigation of cell cycle signaling events using minimally invasive synchronization methods
Start Date / End Date : 28-APR-06 / 27-JUL-07
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Cyclin-dependent control of neuronal proliferation differentiation and death: relevance to Neurodegeneration
Start Date / End Date : 01-OCT-02 / 30-SEP-05

Recent Postgraduates

Rachel O' Farrell, MD (2009) 

Post-doctoral research fellow: Therese Montgomery 2008-2009.

Caitriona Monaghan (MSc 2010)

Ismat Elsaigh (MD 2011)

Current Postgraduate Students

Peter Crowley, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

Teaching the skills required for life-long learning. Encouraging independent thought and the integration of knowledge. Driving ambition among students and the preservation of high standards in our degree programmes. Encouraging our students to be patient-focused from an early stage.
 

Enhancement of Teaching

I constantly strive to enhance the quality of my teaching, embracing new technologies, encouraging feedback from students and adapting the assessment strategy so that it improves the educational experience and encourages self-direction by students. Soon after my academic appointment to the Department of Pathology in 2003 I took on the task of co-ordinating feedback from all pathology-led modules and helping module coordinators close the feedback loop. This was an excellent training platform for me and made me acutely aware of quality control in teaching. Since the feedback system became automated I have encouraged students to participate and this has produced a year-on-year increase in participation in the surveys which, in turn, has driven change. I have introduced reflective diaries as an assessment strategy this year in two modules to encourage mature engagement with hospital field trips, and I have sourced excellent online material from BMJ learning that enables self-directed, but guided, learning. In the Stem Cells module I have used video technology extensively and worked closely with the library staff to develop students' literature analysis and scientific writing, since these are key transferable skills. My involvement in the development of a thematic PhD Programme has helped me hone my postgraduate teaching skills, especially in bridging the clinician-scientist gap. Working with the graduate entry medicine students to address obvious gaps in their teaching needs has made me keenly aware of the importance of tailoring curricula to individual audiences.

Review and Enhancement of Curriculum

I designed the curriculum for a new elective module in an upcoming area of medicine - Stem cells and Regenerative Medicine - in 2008, and have been module co-ordinator for three academic years (PATH30150). As this is a fast moving area, I bring in external speakers who are at the cutting edge of this field, with updates each year. These include surgeons and other clinicians using regenerative medicine techniques, regulatory affairs specialists and bioethics and legal experts. Since taking over co-ordination of the Mechanisms of Disease module (PATH 30080) 4 years ago I have significantly adapted both the lecture content, especially in the area of pharmacology, and the overall learning strategy for the module. In particular this has involved a shift towards greater emphasis on e-learning where appropriate and on teaching students to holistically integrate material from different subject areas through the use of case-based scenarios. I have recently taken over co-ordination of another module under the Graduate Entry Medicine Programme (MDSA 30210) and have also set about updating this module to include e-learning. With regard to developing post-graduate curricula, I was a founding member of the Translational Medicine PhD Programme Committee at its inception in 2007 and since then have been actively involved in designing the original curriculum for the taught aspects of this programme, modifying it in response to student feedback and coordinating some aspects. In September 2009, I provided around 10 hours of informal, emergency remedial teaching in chemistry and pharmacology to non-science graduates who had entered our Graduate Entry Medicine Programme and were struggling with the basic science material. I was an active member of a small group of academics that designed a new module around that material to address this need in 2010 (Molecules in Medicine MDSA10240) and I deliver all pharmacology content on that module.

Developing as a Teacher

I regularly attend courses in the Centre for Teaching and Learning and am always keen to adapt my teaching practices in line with best practice developments in medical education and in response to student feedback. These include the introduction of video-based material, literature critique skill-based assignments, online assignments on Blackboard, and novel e-learning initiatives (see innovation & leadership). I have published two pedagogical articles in leading Medical Education journals. One of those articles, which addressed interprofessional education, has been downloaded over 500 times. It remained as one of the top 5 downloaded articles in Advances in Health Sciences Education for over three months when published online in 2010 and was subsequently selected for inclusion in the printed journal. Gallagher RM and Gallagher HC (2012) Improving the working relationship between doctors and pharmacists: Is inter-professional education the answer? Adv. Health Sci Educ. 17, 247-257. Gallagher HC (2010) New fitness-to-practice requirements for pharmacists in Ireland: Implications for undergraduate pharmacy education. Med Teach 32, e71-7 I delivered an oral presentation at the UCD College of Life Sciences Teaching and Learning Symposium in February 2011 entitled 'Interdisciplinary education as a way of overcoming traditional differences in healthcare'. I have provided academic mentorship to Special Lecturers in Pathology since 2009.

Innovation & Leadership

Driving forward new e-learning initiatives in the SMMS through key external collaboration. Preparing our students for a career with CPE at its core by providing them with key transferable skills. Encouraging reflective learning practices and self-directed learning. Providing challenging assessment strategies to encourage students to be ambitious and to achieve high standards.

Collaborators

Internal Collaborators

Prof Peter Kelly,

 

Prof Donal Buggy

Department of Anaesthesia, Mater Hospital, Dublin

Dr Michelle Butler
School of Nursing and Midwifery, UCD

External Collaborators


Prof Martin Henman
School of Pharmacy and Pharmaceutical Sciences,
Trinity College Dublin,
Dublin 2.