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Researchers at UCD

researcher

Jack Lambert

Consultant/Senior Lecturer

School of Medicine & Medical Science

Tel:
Email: jlambert@mater.ie

Professional

Honours and Awards

Year: 1984.
Title: Outstanding House Staff Teaching Award, Dept. of Pediatrics, Strong Memorial Hospital.

Associations

Association: American Society of Microbiology, Function/Role:
Association: Pediatric Infectious Disease Society, Function/Role:
Association: International Association of AIDS Physicians, Function/Role:
Association: British HIV Association, Function/Role:
Association: Childrens HIV Association of the UK and Ireland (CHIVA), Function/Role:
Association: Medical Society for Study of Venereal Diseases, Function/Role:
Association: Infectious Diseases Society of America, Function/Role:
Association: Fellow Royal College of Paediatrics and Child Health , Function/Role:
     

Conference Contributions

Noguira Susie, Barretto J, da Costa, Lambert JS, Dias Marcos. ; (2002) Estrategias Educacionais pra a capacitacao de professionals de saude da transmissio vertical do HIV. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas,, * , 01-APR-02.
Elizabeth S Machado, Lambert JS, Watson DC, et al. ; (2002) Analise genotipica em criancas HIV-1 + em uso de terapia antiretroviral dupla ou tripla: resistencia ou baixa adesao. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Machado E, Lambert JS, Afonso AO, Cunha SC, Caride E, Nogueira S, Oliveira RH, Watson DC, Sill AM, DeVico Al and Tanuri A.; (2002) Distribuicao dos Subtipos de HIV-1 em Criancas Soropositivas Acompasnhadas no Ippmg. [Non Refereed Paper/Abstract Presented at Conference], XXXVIII Congress de Soliedade Brasilkeira de Medicina Tropical, Rio De Janeiro , 01-FEB-02.
Nogueria S, Correa R, Holanda M, Cruz M & Lambert JS; (2002) Prevalencia de Strongyloides Stercoralis em Pacientes Infectados Pelo HTLV-1 Provenientes de uma Casuistica Hospitalar. [Non Refereed Paper/Abstract Presented at Conference], XXXVIII Congress de Soliedade Brasilkeira de Medicina Tropical, Rio de Janeiro , 01-FEB-02.
Watts DH, Lambert JS, Stiehm ER, Harris DR, Bethel J, Mofenson L, Mathieson B, Fowler MG, Nemo G.; (2003) Clinical, , Virologic, and Immunologic Changes after Delivery among Women Receiving Nucleoside Therapy during Pregnancy. [Oral Presentation], 10th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, USA , 10-FEB-03 - 14-FEB-03.
Johnson D, McFarland E, Muresan P, Fenton T, Lambert JS, McNamara J, Hawkins E, Boquin P, Estep S, Read J, Gunurathan S; (2003) PACTG326: A Phase 1/II study of the Safety and Immunogenicity of an HIV-1 ALVAC Vaccine in Infants Born to HIV-Infected Mothers. [Non Refereed Paper/Abstract Presented at Conference], 10th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, USA , 10-FEB-03 - 14-FEB-03.
McFarland E, Johnson D, Fenton T, Muresan P, McNamara J, Hawkins E, Estep S, Read J, Gunurathan S, Lambert JS ; (2003) A Phase 1/II study of the Safety and Immunogenicity of an HIV-1 ALVAC Vaccine in Infants Born to HIV-Infected Mothers. [Oral Presentation], 10th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, USA , 10-FEB-03 - 14-FEB-03.
Afonso AO, Soares MA, Lambert JS, Cunha SM, Oliveira RH, Machado ES.; (2004) Early emergence of drug resistance mutations in HIV infected children starting dual and triple therapy. [Oral Presentation], XV International Conference on AIDS, Bangkok Thailand , 01-JAN-04.
Nogueira SA, Pinheiro T, Abreu TF, Machado ES, Lambert JS.; (2004) Successful prevention of mother to child transmission with HAART in a developing country. [Oral Presentation], XV International conference on AIDS, Bangkok Thailand , 01-JAN-04.
Lambert JS, McLean KA, Mandalia S. et al.; (2004) Review of HSV simplex type 1 and 2 type specific serology requests performed at three GUM clinics. [Oral Presentation], BASSH Conference, Bath , 01-JAN-04.
McFarland E, Johnson D, Lambert JS et al.; (2005) Safety and Cell-mediated Immune Response to Prime-Boost Immunization with ALVAC HIV Vaccine in infants born to HIV infected Mothers (PACTG 326). [Oral Presentation], CROI, Boston USA , 01-JAN-05.
Machado E, Hofer C, Nogueira S, Costa T, Lambert JS.; (2005) Pregnancy outcome in HIV-1 infected women receiving combination therapy prior to conception. [Poster Presentation], CROI, Boston USA , 01-JAN-05.
Cunha DC Guimaraes MAA, Nogueira SA, Rodrigues R, Lambert JS. ; (2004) Co-infection of HTLV-1 and HIV in a cohort of pregnant women in the city of Rio de Janeiro, Brazil. [Oral Presentation], XV International Conference on AIDS, Bangkok Thailand , 01-JAN-04.
Machado ES, Lambert JS, Schrago C et al. ; (2004) Higher selective pressure on V3 crown of HIV-infected children with longer survival. [Oral Presentation], XV International Conference on AIDS,, Bangkok Thailand , 01-JAN-04.
Machado ES, Lambert JS, Afonso AO et al.; (2004) Alternative, age-related routes of nelfinavir resistance in HIV type 1 infected children under highly active antiretroviral therapy. [Oral Presentation], XV International Conference on AIDS, Bangkok Thailand , 01-JAN-04.
Sukumaran V, McCoy K, Howard R, Lambert JS. ; (2007) Cervical cancer screening: a retrospective review of smear results in the setting of a sexual health clinic. [Published Abstract], BASHH Spring Meeting, Blackpool , 01-OCT-07.
Lambert JS, Sill AM, Machado ES, Watson D, Devico A.; (2006) High production of HIV suppressive chemokines correlates with favourable clinical parameters in HIV-infected children receiving antiretroviral therapy. [Oral Presentation], World AIDS Conference, Toronto, Canada , 01-JAN-06.
Lambert, J.; (2006) TB and HIV: from Africa to the EU. [Oral Presentation], TB - A Global Disease, International Approaches for control and prevention and a model programme for Ireland, World TB Day, Post Graduate Centre, Mater Misericordiae Hospital, Eccles St, Dublin 7 , 01-MAR-06.
Lambert, J.; (2006) STIs in Pregnancy. [Oral Presentation], Society for the Study of Sexually Transmitted Diseases in Ireland, Spring Meeting, Castleknock, Dublin 15 , 01-MAR-06 - 01-MAR-06.
Beatriz A Carvalho, Lambert JS, Barbosa M, Ney A Grillo.; (2002) Funded by the Elizabeth GlaserPaediatric AIDS foundation. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Susie Nogueria, Elizabeth S Machado, Tomaz P da Costa, Thalita F Abreu, and Lambert JS.; (2002) Infeccao pelo HIV em Adolescentes Gestantes: Mais um Problema A ser Enfrentado. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Susie Nogueria, Elizabeth S Machado, Tomaz P da Costa, Thalita F Abreu, Ricardo Oliveira, Marcia Bondarowski, and Lambert JS. ; (2002) Evolocao do Uso de anti-retrovirais e Tipo de parto Num Programa de prevencao da transmissao vertical do HIV. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Nogeria S, Machado E, Costa T, Abreu T, Taveraes M, Oliveria RH & Lambert JS.; (2002) Evolution of the use of antiretrovirals (ARV) to prevent HIV MTCT in Rio de Janeiro, Brazil. [Non Refereed Paper/Abstract Presented at Conference], XIV AIDS Conference, Barcelona , 01-JAN-02.
Nogueria S A, Lambert JS; (2002) Co-infection with Toxoplasma gondii in a cohort of HIV infected pregnant women. [Refereed Abstracts], XIV AIDS Conference, Barcelona , 01-JAN-02.
Susie Nogueria, Elizabeth S Machado, Tomaz P da Costa, Maria Angelica Maan, Raimunda Rodrigues & Lambert JS.; (2002) Prevalencia de Co-infeccoes numa coorte de gestantes infectadas pelo HIV no Rio de Janeiro. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Lambert JS.; (2002) Mitochondrial Toxicity and HIV Therapy. [Non Refereed Paper/Abstract Presented at Conference], IV Conferencia sobre Infeccao pelo HIV Em Mulchers E Criancas, * , 01-APR-02.
Nogueria S A, Lambert JS. ; (2002) Changes over time in the use of antiretrovirals to prevent vertical transmission of HIV. [Refereed Abstracts], XIV AIDS Conference, Barcelona , 01-JAN-02.
             

Other Activities

PEER REVIEW WORK
Journal of Infectious Diseases
• Journal of Pediatrics
• Pediatrics
• Clinical Immunology
• AIDS Research
• Clinical Infectious Diseases
• Archives of Pediatrics and Adolescent Medicine
• Clinical and Diagnostic Laboratory Immunology
• Annals of Internal Medicine
• J. Acquired Immunodeficiency Syndrome
• J. Institute of Human Virology
• International J of STD and AIDS
Ad Hoc Review of Proposals:
• Pediatric AIDS Foundation--Grant Review
• NIDA Grant Review
• NIAID - AIDS Grant Review
Review of Publications:
• U.S.P. Drug Information Text
• American Hospital Formulary Drug Information

Publications

     

Peer Reviewed Journals

Chew, NS,Sheehan, GS,Lambert, J,McConkey, SJ,Cotter, EJ,Doran, PP,Powderly, WG (2012) 'HIV-associated osteoporosis in Ireland: prevalence and risk factors'. Future Virology, 7 :791-799. [DOI] [Details]
O'Halloran, JA,De Gascun, CF,Dunford, L,Carr, MJ,Connell, J,Howard, R,Hall, WW,Lambert, JS; (2011) 'Hepatitis B virus vaccine failure resulting in chronic hepatitis B infection'. Journal of Clinical Virology, 52 :151-154. [DOI] [Details]
Satchell, CS,O'Halloran, JA,Cotter, AG,Peace, AJ,O'Connor, EF,Tedesco, AF,Feeney, ER,Lambert, JS,Sheehan, GJ,Kenny, D,Mallon, PWG; (2011) 'Increased Platelet Reactivity in HIV-1-Infected Patients Receiving Abacavir-Containing Antiretroviral Therapy'. Journal of Infectious Diseases, 204 :1202-1210. [DOI] [Details]
Lambert, JS,Else, LJ,Jackson, V,Breiden, J,Gibbons, S,Dickinson, L,Back, DJ,Brennan, M,Connor, EO,Boyle, N,Fleming, C,Coulter-Smith, S,Khoo, SH; (2011) 'Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy'. HIV Medicine, 12 :166-173. [DOI] [Details]
92. PENPACT-1 (PENTA 9/PACTG 390) Study Team, A. Babiker, H. Castro nee Green H, A. Compagnucci, S. Fiscus, C. Giaquinto, DM. Gibb, L. Harper, L. Harrison, M. Hughes, R Mc Kinney, A. Melvin, L. Mofenson, Y. Saidi, ME. Smith, G. Tudor-Williams, AS. Walker. Collaborators J. Lambert et al. ; (2011) 'First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial'. The Lancet, . [Details]
Caswell, RJ,Phillips, D,Chaponda, M,Khoo, SH,Taylor, GP,Ghanem, M,Poulton, M,Welch, J,Gibbons, S,Jackson, V,Lambert, JS; (2011) 'Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir'. AIDS, 22 :11-14. [DOI] [Details]
F. Kearney, AR. Moore, CF. Donegan, J. Lambert; (2010) 'The ageing of HIV: implications for geriatric medicine'. Age and Ageing, . [Details]
Coulter-Smith S, Lambert JS, Butler K, Brennan M, Cafferkey M. HIV ; (2010) 'HIV testing and treatment in the antenatal care setting'. Irish Medical Journal, 103 (1):14-17. [Details]
Stellbrink, HJ,Orkin, C,Arribas, JR,Compston, J,Gerstoft, J,Van Wijngaerden, E,Lazzarin, A,Rizzardini, G,Sprenger, HG,Lambert, J,Sture, G,Leather, D,Hughes, S,Zucchi, P,Pearce, H,ASSERT Study Grp; (2010) 'Comparison of Changes in Bone Density and Turnover with Abacavir-Lamivudine versus Tenofovir-Emtricitabine in HIV-Infected Adults: 48-Week Results from the ASSERT Study'. Clinical Infectious Diseases, 51 :963-972. [DOI] [Details]
Swan, D,Long, J,Carr, O,Flanagan, J,Irish, H,Keating, S,Keaveney, M,Lambert, J,McCormick, PA,McKiernan, S,Moloney, J,Perry, N,Cullen, W; (2010) 'Barriers to and Facilitators of Hepatitis C Testing, Management, and Treatment Among Current and Former Injecting Drug Users: A Qualitative Exploration'. AIDS Patient Care and Stds, 24 :753-762. [DOI] [Details]
83. FM. Fusco, S Schilling, V Puro, HR. Brodt, P. Follin, B. Jarhall, B. Bannister, HC. Maltezou, G. Thompson, P. Brouqui, G. Ippolito, EURONHID Study Group. Collaborators: O. Adrami, M. Borg, R. Gottschalk, R. Hemmer, A. Horban, M. Kojouharova, C Peronne, J. Lambert, H. Siikamaki, P. Skinhoj, F. Strle, A. Trilla, N Vetter. ; (2009) 'EuroNHID checklists for the assessment of high-level isolation units and referral centres for highly infectious diseases: results from the pilot phase of a European survey'. CLINICAL MICROBIOLOGY AND INFECTION, . [Details]
78. Machado E, Hofer C, Nogueira S, Costa T, Oliveira R, Abreu T, Farias I FA, Mercandante R TS, Garcia MFL, Neves R, Costa V, Lambert J; (2008) 'Pregnancy outcome in HIV-1 infected women receiving combination therapy prior versus after conception'. Sexually Transmitted Infections, . [DOI] [Details]
Cotter A, Treacy A, O¿Keane C, Mulligan N, Lambert J; (2008) 'Cultaneous T-cell Lymphoma presenting as a ten-month history of unilateral facial swelling'. Irish Medical Journal, . [Details]
Cotter, A.,Downes, M. R.,O'Keane, C.,O'Gorman, P.,Lambert, J.; (2009) 'Multicentric Castleman's disease & HIV infection'. Ir Med J, 102 (99):294-5294. Available Online [Details]
Lambert, JS,Machado, ES,Watson, DC,Sill, AM,Lim, JK,Charurat, M,Cunha, SM,Afonso, AO,Oliviera, RH,Tanuri, A,DeVico, AL; (2007) 'Production of the HIV-suppressive chemokines CCL3/MIP-1 alpha and CCL22/MDC is associated with more effective antiretroviral therapy in HIV-infected children'. Pediatric Infectious Disease Journal, 26 :935-944. [DOI] [Details]
Satchell, CS,Cotter, AG,O'Connor, EF,Peace, AJ,Tedesco, AF,Clare, A,Lambert, JS,Sheehan, GJ,Kenny, D,Mallon, PWG; (2010) 'Platelet function and HIV: a case-control study'. AIDS, 24 :649-657. [DOI] [Details]
Roe B, Coughlan S, Dean J, Lambert JS, Keating S, Norris S, Bergin C, Hall WW; (2009) 'Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients'. Viral Immunology, 22 :39-48. [Details]
McMenamin MB., Jackson AD, Lambert J, Hall W, Butler K, Coulter-Smith S, McAuliffe F ; (2008) 'Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs'. American Journal of Obstetrics and Gynecology, 199 (315):e1-e5. Available Online [Details]
Gallagher, D. P., Kieran, J., Sheehan, G., Lambert, J., Mahon, N., Mallon, P. W. G. (2008) 'Ritonavir-boosted atazanavir, methadone, and ventricular tachycardia: 2 case reports'. Clinical Infectious Diseases, 47 (3):36-38. [Details]
McStravick, I; Flynn, K; Lambert, J; Teahan, N; Waghorne, WE; ; (2001) 'Enthalpy of transfer of -CH2- between water and organic solvents or mixed aqueous organic solvent systems'. Journal of Molecular Liquids, 94 (2):145-153. [Details]
McMillan HM, O'Carroll H, Lambert JS, Grundy KB, O'Reilly M, Lennon B, Collins C, Walsh TA, , Geary MP, Cafferkey MK.; (2007) 'Screening for Chlamydia trachomatis in asymptomatic women attending outpatient clinics in a large maternity hospital in Dublin'. Sexually Transmitted Infections, 82 (6):503-506. [Details]
Lambert JS; (2007) 'Long-term follow-up of a quadrivalent HPV vaccine'. Expert Review of Vaccines, 6 (2):141-145. [Details]
Samuel M, Aderogba K, Dutt N, Lambert JS, Taylor C.; (2007) 'A hat trick of ulcerating pathogens in a single genital lesion'. International Journal of Std and Aids, 18 (1):65-66. [Details]
McDonald C, Lambert JS, Nayagam D, Welz T, Poulton M, Aleksin D, Welch J.; (2007) 'Why are children still being infected with HIV? Experience in the prevention of mother to child transmission of HIV in South London'. Sexually Transmitted Infections, (83):59-63. [Details]
Scott CJ, Lambert JS, Taylor CB, Poulton MB; (2007) 'Invasive Aspergillus fumigatus associated with liver and bone involvement in a patient with AIDS'. Journal of Infectious Diseases, 18 (1):65-66. [Details]
McFarland, EJ; Johnson, DC; Muresan, P; Fenton, T; Tomaras, GD; McNamara, J; Read, JS; Douglas, SD; Deville, J; Gurwith, M; Gurunathan, S; Lambert, JS; ; (2006) 'HIV-1 vaccine induced immune responses in newborns of HIV-1 infected mothers'. AIDS, 20 (11):1481-1489. [Details]
McMillan, HM; O'Carroll, H; Lambert, JS; Grundy, KB; O'Reilly, M; Lennon, B; Collins, C; Walsh, TA; Geary, MP; Cafferkey, MT; ; (2006) 'Screening for Chlamydia trachomatis in asymptomatic women attending outpatient clinics in a large maternity hospital in Dublin, Ireland'. Sexually Transmitted Infections, 82 (6):503-505. [Details]
Lambert JS, Mofenson L, Moye J, Mathieson B et al. ; (2005) 'Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal HIV transmission and infant infection'. Clinical and Diagnostic Laboratory Immunology, 12 (5):622-631. [Details]
Chew N, Lambert JS. ; (2005) 'Meeting report of the 10th European AIDS Conference'. Journal of HIV Therapy, 10 (4):79-80. [Details]
Lambert JS, Clapson M.; (2005) 'In search of a paediatric HIV vaccine: scientific and ethical issues'. HIV Nursing, 5 (4):9-12. [Details]
Lambert JS.; (2005) 'HIV vaccines in infants and children'. Paediatric Drugs, 7 (5):267-276. [Details]
Johnson DC, McFarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin P, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert, JS.; (2005) 'Safety and Immunogenicity of an HIV-1 Recombinant Canarypox Vaccine in Newborns and Infants of HIV-1-Infected Women'. Journal of Infectious Diseases, 192 :2129-2133. [Details]
Machado ES, Lambert JS, Watson et al. ; (2004) 'Genotypic resistance and HIV-1 subtype in Brazilian children on dual and triple combination therapy'. Journal of Virology, 30 :24-31. [Details]
Machado ES, Lambert JS, Afonso O et al.; (2004) 'Overview of genotypic and clinical profiles of human immunodeficiency virus type 1 infected children in Rio de Janeiro, Brazil'. Annaes da Academia Brasileira, 76 (3). [Details]
Machado ES, Lambert JS, Afonso et al. ; (2004) 'Alternative age and viral load related routes of nelfinavir resistance in HIV-1 infected children under highly active antiretroviral therapy'. Journal of Paediatrics, 23 (11):10-11. [Details]
Lambert JS, Harris DR, Stiehm ER, Moye J Jr, Fowler MG, Meyer WA, Bethel J, Mofenson LM. ; (2003) 'Performance Characteristics of HIV-1 culture and HIV-1 DNA and RNA amplification assays for early diagnosis of perinatal HIV-1 infection'. Journal of Acquired Immune Deficiency Syndrome, 15 (349 (5)):512-519. [Details]
Lambert JS, Nogueira SA, Abreu T, Machado ES et al. ; (2003) 'A pilot study to evaluate the safety and feasibility of the administration of AZT/3TC fixed dose combination to HIV infected pregnant women and their infants in Rio de Janeiro, Brasil'. Sexually Transmitted Infections, 79 (6):448-524. [Details]
Sutmoller F, Therezinha LP, De Souza CT, Lambert JS.; (2002) 'Human Immunodeficiency Virus incidence and Risk Behavior in the 'Projecto Rio' results of the first five years of the Rio de Janeiro Open Cohort of Homo-Bisexual Men'. Journal of Infectious Diseases, 6 (4):259-265. [Details]
Nogueira SA, Guedes AL, Machado ES, Matos JA, Costa TP, Corte EM, Lambert JS; (2002) 'Toxoplasma encephalitis in an HIV infected pregnant woman with successful outcome for both mother and child'. Brazilian Journal of Infectious Diseases, 6 (4):201-205. [Details]

Other Journals

Lambert JS et al. ; (2007) 'Production of the HIV Suppressive Chemokines CCL3/MIP-1? and CCL22/MDC is Associated with More Effective Antiretroviral Therapy in HIV-Infected Children' Pediatric Infectious Disease Journal . [Details]
McMillan, H.M., O'Carroll, H., Lambert, J.S., Brundy, K.B., O'Reilly, M., Lennon, B., Collins, C., Walsh, T.A., Geary, M.P. Cafferkey, M.T.; (2006) 'Screening for Chlamydia trachomatis in asymptomatic women attending outpatient clincks in a large maternity hospital in Dublin, Ireland' Sex Transm Infect . [Details]
Lambert JS, Clapson M.; (2005) 'In search of a paediatric HIV vaccine: scientific and ethical issues' HIV Nursing 5 (4) . [Details]
Lambert, J.S.; (2005) 'HIV vaccines in infants and children' Paediatr Drugs . [Details]
Lambert, J.S., Moye, J. Jr., Plaeger, S.F., Stiehm, E.R., Bethel, J., Mofenson, L.M., Mathieson, B., Kagan, J., roseblatt, H., Paxton, H., Suter, H., Landay, A.; (2005) 'Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficienty virus transmission and infant infection' Clin Diagn Lam Immunol . [Details]

Conference Publications

McMenamin, MB,Jackson, AD,Lambert, J,Hall, W,Butler, K,Coulter-Smith, S,McAuliffe, FM (2008) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs [DOI] [Details]
                       

Abstract

McMenamin, M,Jackson, A,Lambert, J,Smith, SC,Jones, L,McAuliffe, F (2007) Vertical transmission of hepatitis C. Abstract [DOI] [Details]
Cotter, AG,Satchell, CS,O'Halloran, J,Feeney, ER,O'Connor, E,Sheehan, G,Lambert, J,Sabin, CA,Mallon, PWG (2010) The protease inhibitor atazanavir and predictors of prolonged QT interval in HIV-1 infected patients. Abstract [Details]
                                                               

Research

Research Interests

Summary of Clinical Trials/other Research Experience

  1. ACTG 064. A Phase 1 study of the safety and immunogenicity of DDI administered twice daily to HIV infected adults. (Clinical director of Study; PI Dr Ray Dolin).
  2. ACTG 185 A Phase 3 Efficacy Trial of HIVIG administered to HIV infected pregnant women and their newborns. (Principal Investigator of the study).
  3. ACTG 218 A Phase 1/2 Safety and Immunogenicity study of HIV vaccines administered to HIV infected children. (PI, Study Co-Chair)
  4. ACTG 326 A Phase 1/2 Safety and immunogenicity study of HIV vaccines administered to HIV exposed children (PI, Study Chair)
  5. AVEG 102 A Phase 1 study of an HIV vaccine (microgenesys) administered to HIV infected Pregnant women. (PI, Study Co-chair)
  6. AVEG 104 A Phase 1 study of an HIV vaccine (genentech) administered to HIV infected pregnant women (PI, study Co-Chair)
  7. AVEG 018 A Phase 2 study on an UBI microparticulate oral vaccine administered to HIV low risk seronegative adults. (PI, study chair)
  8. Biovir Study A Phase 1/2 study of Combivir administered to HIV infected pregnant women and their newborns in an outpatient clinic in Rio de Janeiro, Brazil. (PI, study Co-Chair).
  9. Hepatitis B Study A Phase 1/2 study of the administration of a Hepatitis B vaccine to newborns born to HIV infected mothers, Sao Paolo, Brazil. (study PI)
  10. Penta 10/MRC A Phase 2 study of the administration of IL-2 to HIVinfected children followed as part of the European Paediatric HIV network. (study co-chair)
  11. Brazil DDI Study A Phase 1 study of the bioequivelance of once daily versus twice daily DDI administered to HIV infected children. (study PI)
  12. Fiocruz Study Establishment of a high risk gay mens cohort, assessing risk of acquisition of STD's in this population followed at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil (Co investigator)
  13. Trichomonas Study: Evaluation of the prevalence of asymptomatic carriage of trichomonas in men attending the STD clinic at the Monroe County Health Department, Rochester NY
  14. Herpes Study: Evaluation of a rapid HSV test kit in a population of STD patients followed at the Monroe County STD clinic, Rochester NY (co-investigator).
  15. STD in Pregnant Women Study Establishment of a Cohort of High risk pregnant women at Fernandez Figeroia Institute, Rio de Janeiro, Brazil, and measurement of prevalence of STDs in this population. Comparison of standard culture techniques with LCR/PCR for GC and chlamydia . (PI, student mentor)
  16. Uganda Peds vaccine study Assessment of attitudes to vaccination in a paediatric clinic in rural Uganda (student mentor)
  17. HIV and syphilis study; Evaluation and characterization of pregnant women co-infected with syphilis and HIV in a pre-natal clinic in Rochester NY (study PI)
  18. Paracoccidiomycosis and HIV Characterization of the association of paracoccidio and HIV (study co-investigator).
  19. Post transfusion hepatitis C study Prevalence and incidence of Hepatitis C in a cohort of transplant patients followed at the Federal University of rio de Janeiro, Brazil. (thesis advisor)
  20. Rapid HIV testing study-Rio de Janeiro and Port of Spain, Trinidad and Tobago. Study of the feasibilty of HIV rapid testing used in labor and delivery for the rapid diagnosis and treatment of HIV infected pregnant women. (study PI)
  21. CDC cervical lavage study Measurement of mucosal antibody from cervical lavage specimens taken from HIV infected pregnant women who were part of the CDC/Thai AZT MTCT study. (consultant to CDC for mucosal immunity study, thesis advisor for student PhD thesis Dr Rutt)
  22. Bacillary angiomatosis study Study of the characterization of relationship and manifestations of HIV and bacillary angiomatosis co-infected patients from a series of hospitals in Rio de Janeiro, Brazil (co-investigator).
    MCTC cohort Chennai Establishment and characterization of a cohort of HIV infected pregnant women followed at a tertiary Care centre, YRG, in Chennai, India (student mentor, co-investigator).
  23. Paediatric HIV cohort Chennai Establishment and characterization of a cohort of HIV infected children followed at the YRG medical clinic in Chennai, India (student mentor, co-investigator).
  24. MTCT cohort Rio Establishment of a cohort of HIV infected pregnant women from the maternities of the Federal University of Rio de Janeiro, Brazil (co-PI).
  25. Paed AIDS cohort Rio Establishment of a cohort of HIV infected and exposed children followed at the Federal University of Rio de Janeiro, Brazil, (co-PI).
  26. Seroprevalence of STD in PG women cohort Rio Establishment and characterization of STD's found in a cohort of pregnant women followed at the State University of Rio de Janeiro, Brazil, (study co-PI and thesis advisor).
    Hepatitis G study Rio Assessment of the prevalence of hepatitis G in a cohort from the Federal University of Rio de Janeiro, Brazil. (study co-PI and thesis advisor)
  27. Pneumococcal vaccine study in HIV infected adults Assessment of the safety and immunogenicity of a conjugate Pn Vaccine in adults with symptomatic HIV infection. (study PI)
  28. Transmission of HIV Subtypes in MTCT: Evaluation of the fidelity of transmission of chimeric HIV from mother to child in the Rio de Janeiro cohort. (study co-PI)
  29. Quest study--quad therapy. Thymic reconstitution following HAART therapy in a cohort of adults followed in a multicentred GSK sponsored study (co-investigator).
  30. Genotypic analysis of HIV infected children: Establishment of cohort and evaluation of genotypic resistance, following therapy, in children followed in the specialty clinics of the Federal University of Rio de Janeiro Brazil. (PI).
  31. Protocol A4001050: A multi-centre open label expanded access trial of Maraviroc
  32. Protocol M05-730: A phase III, randomised, open label, study of Lopinavir/ritonavir tablets versus soft gel capsules and once daily versus twice daily administration, when co-administered with NRTIs in antiretroviral naïve HIV-1 infected subjects
  33. Protocol AI424136: A phase IV, open-label, randomised, multicentre trial assessing the efficacy of a treatment maintenance phase with unboosted vs. boosted Reyataz after an induction phase with Reyataz and Ritonavir in treatment naïve HIV patients (the INDUMA Study)
  34. Euroresistance Study: Strategy to control spread of HIV drug resistance. Official European Commission supported programme
  35. Therapeutic drug monitoring: use in HIV infected pregnant women
  36. Immune response to Tuberculosis in people with and without HIV infection
  37. Protocol M06-802: A phase III, randomised, open label study of Lopinavir/ritonavir tablets 800/200mg once-daily versus 400/100mg twice-daily when co-administered with Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in antiretroviral-experienced, HIV-1 infected subjects
  38. Protocol CNA1095586: Study of Once Daily Abacavir/ Lamivudine versus Tenofir/ Emtricitabime, administered with Efavirenz in antiretroviral niave HIV-1 infected adult subjects.
  39. Barriers to and enablers of hepatitis C screening and treatment among current or former injecting drug users in Ireland:        A qualitative study from two perspectives.  Co investigator with Dr Walter Cullen, PI.
  40. Community Based Hepatitis C Treatment Study: Thompson Street Centre, Dublin 1.  (PI)

  41. Dublin HIV Cohort Study:     Recruitment of patients with HIV from the major teaching hospitals in Dublin.  (Co-Investigator)

  42. Telzir/Hepatitis C Study:        Phase 4 study of telzir treatment in patients with HepC coinfection (PI)

  43. Protocol AI 447-016             A phase 2a/2b study of BMS-650032 in Combination with Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) in Treatment-Naïve Subjects with Genotypes 1 and 4 Chronic Hepatitis C Infection.

  44. Protocol AI444010                A phase 2B Study of BMS-790052 in Combination with Peginterferon Alfa-2a (Pegasys) and Ribavirin in Treatment Naïve Subjects with Chronic Hepatitis C Genotype 1 and 4 infection.

  45. S-COLLATE Study               A Multicentre, Prospective, Observational, Non-Interventional Cohort Study Evaluating On-Treatment Predictors of Response in Subjects with HbeAg positive or HbeAg negative Chronic Hepatitis B Receiving Therapy with PEGASYS® (Peginterferon alfa-2a 40 KD)

  46. Protocol GS-US-196-0103  A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial comparing 24 or 48 weeks of GS-9190, in Combination with Peginterferon Alpha 2a and Ribavirin, to 48 weeks of Peginterferon Alpha 2a and Ribavirin for the Treatment of Genotype-1 Chronic Hepatitis C Virus (HCV) Infection

  47. Investigation into the reasons for HIV infected women not following up for their own care postpartum. MMUH/Rotunda. PI.

  48. PANNA study              Study on Pharmacokinetics of newly developed Antiretroviral agents in HIV-infected pregnant women (PANNA).

Research Projects

Sponsor : GlaxoSmithKline (Ireland) Ltd.
Title : Telzir Study
Start Date / End Date : 01-DEC-08 / 28-FEB-11
   

Collaborators

 

External Collaborators

  • Great Ormond Street Hospital,
    University College, London, UK 
  • University of Maryland at Baltimore
    Institute of Human Virology
    Medical Biotechnology Center
    725 W. Lombard Street, S-521
    Baltimore, Maryland 21201
    410-706-4601, Fax: 410-706-1992
    Email: lambert@umbi.umd.edu