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Researchers at UCD

Katherine Howell

Lecturer

School Of Medicine & Medical Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166730
Email: katherine.howell@ucd.ie

Professional

 

Associations

Association: American Thoracic Society, Function/Role: Member
     

Conference Contributions

Howell, K., Costello, C., McLoughlin, P.; Hypoxia and Lung Disease Conference. [Poster Presentation], European Respiratory Society, Taormina, Sicily .
Nichol, A., Howell, K., Costello, C. & McLoughlin, P.; Hypoxia Conference. [Poster Presentation], Keystone Symposium, Breckenridge, Colorado, USA .
Howell K, Giles J, McLoughlin P.; Irish Symposium. [Poster Presentation], Microscopical Society, Belfast, Ireland .
Howell, K., Preston, R., Fleming, L. and McLoughlin, P.; UK Symposium. [Poster Presentation], Physiological Society, Bristol .
Howell K, Preston, R., Fleming, L. and McLoughlin, P.; Irish Symposium. [Poster Presentation], Irish Thoracic Society, Cavan, Ireland .
Howell, K., Preston, RJ., and McLoughlin, P.; International Symposium. [Poster Presentation], American Thoracic Society (ATS), San Diego .
Howell, K., Preston, RJ., and McLoughlin, P.; International Symposium. [Poster Presentation], ATS, Orlando .
Howell, K., Ooi, H. and McLoughlin, P.; International Symposium. [Poster Presentation], Internation Union of Physiological Society, Christchurch, New Zealand .
Nichol, A., Howell, K. and McLoughlin, P.; (2005) Membrane Channels. [Poster Presentation], Physiological Society, Oxford , 05-SEP-05 - 07-SEP-05.
Howell, K, Preston, R., Fleming L. and McLoughlin, P. ; (2004) International Symposium. [Poster Presentation], ATS, Atlanta , 05-JUL-04 - 08-JUL-04.
   

Education

Year 2002 Institution: University College Dublin
Qualification: PhD Subject:
Year 1994 Institution: University of Sunderland
Qualification: BSc Subject:
         

Publications

     

Peer Reviewed Journals

Sands M, Howell K, Costello CM, McLoughlin P; (2011) 'Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung'. Respiratory research, 12 (1). [DOI] [Details]
Fitzpatrick, SF,Tambuwala, MM,Bruning, U,Schaible, B,Scholz, CC,Byrne, A,O'Connor, A,Gallagher, WM,Lenihan, CR,Garvey, JF,Howell, K,Fallon, PG,Cummins, EP,Taylor, CT; (2011) 'An Intact Canonical NF-kappa B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia'. Journal of Immunology, 186 :1091-1096. [DOI] [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
Howell, K,Costello, CM,Sands, M,Dooley, I,McLoughlin, P; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. American journal of physiology. Lung cellular and molecular physiology, 296 (NA):1042-1050. [DOI] [Details]
Howell, K.,Costello, C. M.,Sands, M.,Dooley, I.,McLoughlin, P.; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. Am J Physiol Lung Cell Mol Physiol, 296 (66). Available Online [Details]
Howell, K,Preston, RJ,McLoughlin, P; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology-London, 547 :133-145. [DOI] [Details]
Nichol, AD,O'Cronin, DF,Howell, K,Naughton, F,O'Brien, S,Boylan, J,O'Connor, C,O'Toole, D,Laffey, JG,McLoughlin, P; (2009) 'Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis'. Critical Care Medicine, 37 :2953-2961. [DOI] [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. Critical Care Medicine, 178 (9):977-983. [DOI] [Details]
McLoughlin P, Costello CM, Howell K, Cahill E, McBryan J, Konigshoff M, Eickelberg O, Gaine S, Martin F, ; (2008) 'Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension'. Cell, 295 (2):1-84. [DOI] [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, 178 (9):977-983. Available Online [DOI] [Details]
Costello, CM,Howell, K,Cahill, E,McBryan, J,Konigshoff, M,Eickelberg, O,Gaine, S,Martin, F,McLoughlin, P; (2008) 'Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension'. American Journal of Physiology-Lung Cellular and Molecular Physiology, 295 :272-284. [DOI] [Details]
Leonard, MO,Howell, K,Madden, SF,Costello, CM,Higgins, DG,Taylor, CT,McLoughlin, P; (2008) 'Hypoxia Selectively Activates the CREB Family of Transcription Factors in the In Vivo Lung'. American Journal of Respiratory and Critical Care Medicine, 178 (NA):977-983. [DOI] [Details]
Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, McLoughlin P; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, . [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, 9 (NA):977-983. [DOI] [Details]
Leonard, M. O.,Kieran, N. E.,Howell, K.,Burne, M. J.,Varadarajan, R.,Dhakshinamoorthy, S.,Porter, A. G.,O'Farrelly, C.,Rabb, H.,Taylor, C. T.; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. Faseb J, 20 (14):2624-6. [Details]
Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'Farrelly C, Rabb H, Taylor CT.; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. Faseb Journal, 20 (14):2624-2626. [Details]
Leonard, MO,Kieran, NE,Howell, K,Burne, MJ,Varadarajan, R,Dhakshinamoorthy, S,Porter, AG,O'Farrelly, C,Rabb, H,Taylor, CT; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 . [DOI] [Details]
Leonard, MO; Kieran, NE; Howell, K; Burne, MJ; Varadarajan, R; Dhakshinamoorthy, S; Porter, AG; O'Farrelly, C; Rabb, H; Taylor, CT; ; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. FASEB JOURNAL, 20 (14):2624-2626. [Details]
Taylor CT, Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'farrelly C, Rabb H, ; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 (NA):2624-2626. [DOI] [Details]
Hyvelin, J. M.,Howell, K.,Nichol, A.,Costello, C. M.,Preston, R. J.,McLoughlin, P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circ Res, 97 (2):185-91. [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. [Details]
Hyvelin, JM,Howell, K,Nichol, A,Costello, CM,Preston, RJ,McLoughlin, P; (2005) 'Inhibition of rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation, 97 :185-191. [DOI] [Details]
McLoughlin P, Hyvelin JM, Howell K.; (2005) 'Pulmonary hypertension'. New England Journal of Medicine, 352 (4):418-419. [Details]
McLoughlin P, Howell K, Ooi H, Preston R, ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Shortt, AJ, Howell, K, O'Brien, C, McLoughlin, P, ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [DOI] [Details]
Shortt, AJ; Howell, K; O'Brien, C; McLoughlin, P; ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [Details]
Howell, K; Ooi, H; Preston, R; McLoughlin, P; ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Kirwan, C; Howell, K; O'Brien, CO; McLoughlin, P; ; (2004) 'The role of nitric oxide in angiogenesisin the globally hypoxic retina'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):739-739. [Details]
Shortt, AJ,Howell, K,O'Brien, C,McLoughlin, P; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 :349-356. [Details]
McLoughlin P, Shortt AJ, Howell K, O'Brien C, ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [DOI] [Details]
Howell, K; Preston, RJ; McLoughlin, P; ; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology-London, 547 (1):133-145. [Details]
Howell, K; Hopkins, N; McLoughlin, P; ; (2002) 'Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues'. Experimental Physiology, 87 (6):747-756. [Details]
McLoughlin P, Ooi H, Cadogan E, Sweeney M, Howell K, O'Regan RG, ; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. The Journal of physiology, 278 (2):1-8. [Details]
Ooi, H,Cadogan, E,Sweeney, M,Howell, K,O'Regan, RG,McLoughlin, P; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. The Journal of physiology, 278 :331-338. [Details]
Ooi, H, Cadogan, E, Sweeney, M, Howell, K, O'Regan, RG, McLoughlin, P, ; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. American Journal of Physiology-Heart and Circulatory Physiology, 278 (2):331-338. [Details]
 

Conference Publications

Cahill E, Costello CM, Howell K, Southwood M, Leonard, M.O., Morrell NW, McLoughlin P; (2010) Lung-Selective Hypoxia-Induced Secretion of the BMP Antagonist Gremlin in Pulmonary Hypertension Keystone Symposium [Details]
Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P; (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society International Conference [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Conference Birmingham 2010 [Details]
Cahill E, Costello CM, Howell K, Harkin S, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2010) Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension American Thoracic Society International Conference 2010 [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells European Respiratory Society Lung Biology Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells Physiological Society Annual Meeting [Details]
Costello, CM, Howell K, Brennan D, Doherty S, Martin, F, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress European Respiratory Society Lung Biology Meeting [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
Nichol, A., Howell, K. Mc Loughlin, P.; (2005) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Physiological Society Smooth Muscle Symposium [Details]
Howell, K, Ooi, H, Giles, J, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypoxia increases alveolar capillary endothelial surface area in adult rats , pp.294-295 [Details]
                                                                                         

Research

Research Interests

Research Projects

Sponsor : University College Dublin (UCD)
Title : Elucidating the role of Placental Growth Factor in Mediating Hypoxia-Induced Pulmonary Angiogenesis & Co-ordinated Epithelial Growth in the Adult Hypoxic Lung
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : Health Research Board (HRB)
Title : Elucidating the role of placental growth factor in mediating hypoxia-induced pulmonary angiogenesis and co-ordinated epithelial growth in the adult hypoxic lung
Start Date / End Date : 01-OCT-08 / 30-SEP-12
Sponsor : University College Dublin (UCD)
Title : Acquisition of bone-marrow transplantation technique to elucidate the role of bone-marrow derived endothelial progenitor cells
Start Date / End Date : 04-JAN-07 / 20-DEC-07