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Researchers at UCD

Madeline Murphy

Senior Scientist

School Of Medicine & Medical Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166818
Email: madeline.murphy@ucd.ie

Biography

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Dr Murphy obtained her PhD from University College Dublin and has been leading a research group in the UCD Conway Institute since 2006. Her research focus is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved diagnostics and therapeutics for fibrotic disease and more recently for cancer.  She has published extensively in peer reviewed scientific journals and received research grant income from Breast Cancer Campaign, Wellcome Trust, Science Foundation Ireland, Health Research Board and National Children¿s Research Centre.

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Publications

     

Peer Reviewed Journals

Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C (2013) 'Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1'. Journal of the American Society of Nephrology, 24 (4):627-637. [DOI] [Details]
Murphy M, Hickey F, Godson C (2013) 'IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease'. Current Opinion in Nephrology and Hypertension, 22 (1):77-84. [DOI] [Details]
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses'. Biochimica et biophysica acta, 1833 (8):1969-1978. [DOI] [Details]
Kelly NA, Murphy M, Giles S, Russell JD (2012) 'Subglottic injury: a clinically relevant animal model'. The Laryngoscope, 122 (11):2574-2581. [DOI] [Details]
Rowan F, Coffey JC, Oʼconnell PR, Docherty NG, Murphy M, Murphy TB.; (2011) 'Ileal Pouch Microbial Diversity'. Annals of Surgery, . [Details]
Borgeson, E,Docherty, NG,Murphy, M,Rodgers, K,Ryan, A,O'Sullivan, TP,Guiry, PJ,Goldschmeding, R,Higgins, DF,Godson, C; (2011) 'Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis'. FASEB Journal, 25 :2967-2979. [DOI] [Details]
Hickey, FB,Corcoran, JB,Docherty, NG,Griffin, B,Bhreathnach, U,Furlong, F,Martin, F,Godson, C,Murphy, M; (2011) 'IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1 alpha'. Journal of the American Society of Nephrology, 22 :1475-1485. [DOI] [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Bacterial colonisation of colonic crypts correlates with disease activity in ulcerative colitis'. Annals of Surgery, 252 (5):869-875. [DOI] [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR; (2010) 'Bacterial Colonization of Colonic Crypt Mucous Gel and Disease Activity in Ulcerative Colitis'. Annals of Surgery, 252 :869-874. [DOI] [Details]
Brennan, EP,Ehrich, M,Brazil, DP,Crean, JK,Murphy, M,Sadlier, DM,Martin, F,Godson, C,van den Boom, D,Maxwell, AP,Savage, DA; (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Gene, 5 :396-401. [Details]
McKnight, AJ,Patterson, CC,Pettigrew, KA,Savage, DA,Kilner, J,Murphy, M,Sadlier, D,Maxwell, AP,Warren 3 UK Genetics Kidneys Diab; (2010) 'A GREM1 Gene Variant Associates with Diabetic Nephropathy'. J AM SOC NEPHROL, 21 :773-781. [DOI] [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA.; (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Diseases of the Colon and Rectum, 53 (11):1530-1536. [DOI] [Details]
Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O¿Connell PR; (2010) 'CULTURE INDEPENDENT QUANTIFICATION OF TOTAL BACTERIAL COLONIZATION OF COLONIC CRYPTS IN PATIENTS WITH ULCERATIVE COLITIS AND CONTROLS'. Annals of Surgery, . [Details]
Hickey FB, Ryan A, Murphy M, Godson C, ; (2009) 'Diabetes mellitus and apoptosis: inflammatory cells'. Apoptosis, . [DOI] [Details]
Brennan, EP,Ehrich, M,Brazil, DP,Crean, JK,Murphy, M,Sadlier, DM,Martin, F,Godson, C,McKnight, AJ,van den Boom, D,Maxwell, AP,Savage, DA; (2009) 'Comparative analysis of dna methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Gene, 4 :159-164. [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F,Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA. ; (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 1 (4). [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
Murphy M, Crean JK, Brazil DP, Sadlier D, Martin F and Godson C ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochem J, 36 :941-945. [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, Pt 5 (NA):941-945. [DOI] [Details]
Furlong, F.,Crean, J.,Thornton, L.,O'Leary, R.,Murphy, M.,Martin, F.; (2007) 'Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose'. Am J Physiol Renal Physiol, 292 (6):F1691-700. [Details]
Dolan, V; Murphy, M; Kretzler, M; Mezzano, S; Brady, HR; ; (2006) 'Expression of gremlin in diabetic nephropathy in vivo and epithelial-mesenchymal transdifferentiation in vitro'. Scottish Medical Journal, 51 (1):54-55. [Details]
Lambe, T; Finlay, D; Murphy, M; Martin, F; ; (2006) 'Differential expression of connexin 43 in mouse mammary cells'. Cell Biology International, 30 (5):472-479. [Details]
Roxburgh, SA; Murphy, M; Pollock, CA; Brazil, DP; ; (2006) 'Recapitulation of embryological programmes in renal fibrosis - The importance of epithelial cell plasticity and developmental genes'. Nephron Physiology, 103 (3):139-148. [Details]
Healy, DA, Daly, PJ, Docherty, NG, Murphy, M, Fitzpatrick, JM, Watson, RWG, ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. J AM SOC NEPHROL, 17 (3):805-812. [DOI] [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology-Renal Physiology, 290 (5):1202-1212. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology-Renal Physiology, 290 (5):1202-1212. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Roxburgh, SA; Murphy, M; Pollock, CA; Brazil, DP; ; (2006) 'Recapitulation of embryological programmes in renal fibrosis - The importance of epithelial cell plasticity and developmental genes'. Nephron Physiology, 103 (3):139-148. [Details]
Lambe, T; Finlay, D; Murphy, M; Martin, F; ; (2006) 'Differential expression of connexin 43 in mouse mammary cells'. Cell Biology International, 30 (5):472-479. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Kirwan, RP; Leonard, MO; Murphy, M; Clark, AF; O'Brien, CJ; ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
Conway, BR; Maxwell, AP; Savage, DA; Patterson, CC; Doran, PP; Murphy, M; Brady, HR; Fogarty, DG; ; (2004) 'Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes'. Diabetes, 53 (4):1162-1165. [Details]
Dolan, V; Murphy, M; Alarcon, P; Brady, HR; Hensey, C; ; (2003) 'Gremlin - a putative pathogenic player in progressive renal disease'. Expert Opinion on Therapeutic Targets, 7 (4):523-526. [Details]
Crean, J; Finlay, B; Conway, B; Murphy, M; Godson, G; Brady, HR; Finian, M; ; (2003) 'CCN-2 (CTGF) induces actin rearrangement and mesangial cell motility: Involvement of RhoA and protein kinase C zeta'. Journal of the American Society of Nephrology, 14 (NA):129-129. [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
Clarkson, M., Murphy, M., Gupta, S., Mackenzie, H.S., Godson, C., Martin F., Brady, H.R. ; (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. Journal of Biological Chemistry, 277 (12):9707-9712. [Details]
Lappin, DWP; McMahon, R; Murphy, M; Brady, HR; ; (2002) 'Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy'. Nephrology Dialysis Transplantation, 17 (NA):65-67. [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
Murphy, M., Harte, T., McInerney, J. and Smith, T. ; (2000) 'Molecular cloning of atlantic salmon dinucleoside phosphate kinase and its pattern of expression during embryogenesis'. Gene, 257 (1):139-148. [Details]
Maderna, P; Godson, C; Hannify, G; Murphy, M; Brady, HR; ; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology-Cell Physiology, 279 (4):945-953. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
                                                                                             

Research

Research Interests

My research focuses on molecular mechanisms of renal disease. I have identified a number of potential novel therapeutic targets (e.g. IHG-1, Gremlin, CTGF) that cause diabetic renal disease and use a combination of molecular, cellular, proteomic and bioinformatic analyses to characterise the function of these genes in kidney disease progression. My main research focus is the characterisation of a novel gene, IHG-1, which I identified in 1999 and which I have since shown to amplify TGFbeta-1 signalling reponses.  Interestingly, my group has shown that IHG-1 is a mitochondrial protein with important implications for the resolution of kidney disease. Current investigations include in vivo conditional deletion of IHG‐1 and development of dominant negative IHG-1 as a therapeutic. In collaboration with colleagues in the Conway Institute, we have begun investigating the role of IHG-1 in cancer progression. My group also studies gremlin regulation of profibrotic responses and mitomycin C modulation of subglottic stenosis.