Navigation

Researchers at UCD

researcher

Mark Ledwidge

Adjunct Lecturer

School Of Medicine & Medical Science
Health Sciences Centre
Belfield
Dublin 4

Tel:
Email: mark.ledwidge@ucd.ie

Publications

     

Peer Reviewed Journals

Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
O'Sullivan, S. and Medina, C. and Ledwidge, M. and Radomski, M.W. and Gilmer, J.F. (2014) 'Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance NO and MMP-9 interactions'. Biochimica et Biophysica Acta - Molecular Cell Research, 1843 (3):603-617. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Collier, P. and Horgan, S. and Glezeva, N. and Cooke, G. and Xu, M. and Ledwidge, M. and Mcdonald, K. and Baugh, J.A. (2014) 'Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta'. Connective Tissue Research, 55 (3):248-256. Available Online [DOI] [Details]
Bermingham, M. and Shanahan, M.K. and O'Connell, E. and Dawkins, I. and Miwa, S. and O'Hanlon, R. and Gilmer, J. and McDonald, K. and Ledwidge, M. (2014) 'Aspirin use in heart failure is low-dose therapy associated with mortality and morbidity benefits in a large community population?'. Circulation: Heart Failure, 7 (2):243-250. Available Online [DOI] [Details]
Bermingham, M. and Ryder, M. and Travers, B. and Edwards, N. and Lalor, L. and Kelly, D. and Gallagher, J. and O'Hanlon, R. and McDonald, K. and Ledwidge, M. (2014) 'The St Vincent's potentially inappropriate medicines study: Development of a disease-specific consensus list and its evaluation in ambulatory heart failure care'. European Journal of Heart Failure, 16 (8):915-922. Available Online [DOI] [Details]
Glezeva, N. and Collier, P. and Voon, V. and Ledwidge, M. and McDonald, K. and Watson, C. and Baugh, J. (2013) 'Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide'. Journal of Cardiovascular Translational Research, 6 (4):545-557. Available Online [DOI] [Details]
Ledwidge, M. and Gallagher, J. and Conlon, C. and Tallon, E. and O'Connell, E. and Dawkins, I. and Watson, C. and O'Hanlon, R. and Bermingham, M. and Patle, A. and Badabhagni, M.R. and Murtagh, G. and Voon, V. and Tilson, L. and Barry, M. and McDonald, L. and Maurer, B. and McDonald, K. (2013) 'Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial'. JAMA - Journal of the American Medical Association, 310 (1):66-74. Available Online [DOI] [Details]
Ledwidge, M.T. and O'Hanlon, R. and Lalor, L. and Travers, B. and Edwards, N. and Kelly, D. and Voon, V. and McDonald, K.M. (2013) 'Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?'. European journal of heart failure, 15 (4):447-455. Available Online [DOI] [Details]
Jan, A. and Dawkins, I. and Murphy, N. and Collier, P. and Baugh, J. and Ledwidge, M. and McDonald, K. and Watson, C.J. (2013) 'Associates of an elevated natriuretic peptide level in stable heart failure patients: Implications for targeted management'. The Scientific World Journal, 2013 . Available Online [DOI] [Details]
Phelan, D. and Watson, C. and Martos, R. and Collier, P. and Patle, A. and Donnelly, S. and Ledwidge, M. and Baugh, J. and McDonald, K. (2012) 'Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes'. PLoS ONE, 7 (11). Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Waterhouse, D.F. and Dawkins, I.R. and Patle, A.K. and Horgan, S. and Conlon, C.M. and O'Hanlon, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K. (2012) 'Progression of left atrial volume index in a population at risk for heart failure: A substudy of the STOP-HF (St Vincent's Screening to Prevent Heart Failure) trial'. European Journal of Heart Failure, 14 (9):957-964. Available Online [DOI] [Details]
Collier, P. and Ledwidge, M. and McDonald, K. (2012) 'Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology'. QJM, 105 (8):721-724. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Xu, M. and Collier, P. and Neary, R. and Smolenski, A. and Ledwidge, M. and McDonald, K. and Baugh, J. (2012) 'Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis'. Fibrogenesis and Tissue Repair, 5 (1). Available Online [DOI] [Details]
Medina, C. and Harmon, S. and Inkielewicz, I. and Santos-Martinez, M.J. and Jones, M. and Cantwell, P. and Bazou, D. and Ledwidge, M. and Radomski, M.W. and Gilmer, J.F. (2012) 'Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin'. British Journal of Pharmacology, 166 (3):938-949. Available Online [DOI] [Details]
Murtagh, G. and Dawkins, I.R. and O'Connell, R. and Badabhagni, M. and Patel, A. and Tallon, E. and O'Hanlon, R. and Ledwidge, M.T. and McDonald, K.M. (2012) 'Screening to prevent heart failure (STOP-HF): Expanding the focus beyond asymptomatic left ventricular systolic dysfunction'. European Journal of Heart Failure, 14 (5):480-486. Available Online [DOI] [Details]
Ledwidge, M.T. and Ryan, F. and Kerins, D.M. and O'Connell, D. and Cefali, G. and Harmon, S. and Jones, M. and Gilmer, J.F. (2012) 'In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D 2: Is this a new immediate-release therapeutic option for niacin?'. Atherosclerosis, 221 (2):478-483. Available Online [DOI] [Details]
Abulhul, E. and McDonald, K. and Martos, R. and Phelan, D. and Spiers, J.P. and Hennessy, M. and Baugh, J. and Watson, C. and O'Loughlin, C. and Ledwidge, M. (2012) 'Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide'. Clinical Therapeutics, 34 (1):91-100. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and van Es, M.H. and Phelan, D. and McGorrian, C. and Tolan, M. and Ledwidge, M.T. and McDonald, K.M. and Baugh, J.A. (2012) 'Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype'. Journal of Molecular and Cellular Cardiology, 52 (1):148-153. Available Online [DOI] [Details]
Harmon, S. and Inkielewicz-Stepniak, I. and Jones, M. and Ledwidge, M. and Santos-Martinez, M.J. and Medina, C. and Radomski, M.W. and Gilmer, J.F. (2012) 'Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets'. Journal of Pharmacy and Pharmacology, 64 (1):77-89. Available Online [DOI] [Details]
Bermingham, M. and McDonald, K. and Ledwidge, M. (2011) 'The authors respond:'. Clinical Therapeutics, 33 (12). Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Voon, V. and Phelan, D. and Jan, A. and Mak, G. and Martos, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K.M. (2011) 'Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?'. European Journal of Heart Failure, 13 (10):1087-1095. Available Online [DOI] [Details]
Bermingham, M. and Hayden, J. and Dawkins, I. and Miwa, S. and Gibson, D. and McDonald, K. and Ledwidge, M. (2011) 'Prospective analysis of ldl-c goal achievement and self-reported medication adherence among statin users in primary care'. Clinical Therapeutics, 33 (9):1180-1189. Available Online [DOI] [Details]
Bermingham, M. and Ocallaghan, E. and Dawkins, I. and Miwa, S. and Samsudin, S. and McDonald, K. and Ledwidge, M. (2011) 'Are beta2-agonists responsible for increased mortality in heart failure?'. European Journal of Heart Failure, 13 (8):885-891. Available Online [DOI] [Details]
Arnous, S. and Murphy, N.F. and Pyne-Daly, P. and Nawoor, Z. and Keane, D. and Ledwidge, M. and McDonald, K. (2011) 'Clinical and psychological impact of prophylactic implantable cardioverter-defibrillators in a community heart failure population'. Irish Journal of Medical Science, 180 (2):369-374. Available Online [DOI] [Details]
Jan, A. and Murphy, N.F. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2011) 'Profiling B-type natriuretic peptide in a stable heart failure population: A valuable adjunct to care'. Irish Journal of Medical Science, 180 (2):355-362. Available Online [DOI] [Details]
Conlon, C.M. and Dawkins, I. and O'Loughlin, C. and Gibson, D. and Kelleher, C.C. and Ledwidge, M. and McDonald, K. (2011) 'B-type natriuretic peptide measurement in primary care; Magnitude of associations with cardiovascular risk factors and their therapies. Observations from the STOP-HF (St. Vincent's Screening to Prevent Heart Failure) study'. Clinical Chemistry and Laboratory Medicine, 49 (4):719-728. Available Online [DOI] [Details]
Watson, C.J. and Ledwidge, M.T. and Phelan, D. and Collier, P. and Byrne, J.C. and Dunn, M.J. and McDonald, K.M. and Baugh, J.A. (2011) 'Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure'. Circulation: Heart Failure, 4 (2):188-197. Available Online [DOI] [Details]
O'Loughlin, C. and Murphy, N.F. and Conlon, C. and O'Donovan, A. and Ledwidge, M. and McDonald, K. (2010) 'Quality of life predicts outcome in a heart failure disease management program'. International Journal of Cardiology, 139 (1):60-67. Available Online [DOI] [Details]
Mak, G.J. and Ledwidge, M.T. and Watson, C.J. and Phelan, D.M. and Dawkins, I.R. and Murphy, N.F. and Patle, A.K. and Baugh, J.A. and McDonald, K.M. (2009) 'Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone'. Journal of the American College of Cardiology, 54 (18):1674-1682. Available Online [DOI] [Details]
Phelan, D. and Smyth, L. and Ryder, M. and Murphy, N. and O'Loughlin, C. and Conlon, C. and Ledwidge, M. and McDonald, K. (2009) 'Can we reduce preventable heart failure readmissions in patients enrolled in a Disease Management Programme?'. Irish Journal of Medical Science, 178 (2):167-171. Available Online [DOI] [Details]
Mockler, M. and O'Loughlin, C. and Murphy, N. and Ryder, M. and Conlon, C. and McDonald, K.M. and Ledwidge, M.T. (2009) 'Causes and Consequences of Nonpersistence With Heart Failure Medication'. American Journal of Cardiology, 103 (6):834-838. Available Online [DOI] [Details]
Martos, R. and Baugh, J. and Ledwidge, M. and O'Loughlin, C. and Murphy, N.F. and Conlon, C. and Patle, A. and Donnelly, S.C. and McDonald, K. (2009) 'Diagnosis of heart failure with preserved ejection fraction: Improved accuracy with the use of markers of collagen turnover'. European Journal of Heart Failure, 11 (2):191-197. Available Online [DOI] [Details]
Mak, G. and Ryder, M. and Murphy, N.F. and O'Loughlin, C. and McCaffrey, D. and Ledwidge, M. and McDonald, K. (2008) 'Diagnosis of new onset heart failure in the community: The importance of a shared-care approach and judicious use of BNP'. Irish Journal of Medical Science, 177 (3):197-203. Available Online [DOI] [Details]
Mak, G. and Murphy, N.F. and Ali, A. and Walsh, A. and O'loughlin, C. and Conlon, C. and McCaffrey, D. and Ledwidge, M. and McDonald, K. (2008) 'Multiple Neurohumoral Modulating Agents in Systolic Dysfunction Heart Failure: Are We Lowering Blood Pressure Too Much?'. Journal of Cardiac Failure, 14 (7):555-560. Available Online [DOI] [Details]
Sulaiman, H.M. and O'Loughlin, C. and Daly, M. and Conlon, C. and Ledwidge, M. and McCaffrey, D. and McDonald, K. (2008) 'Need and evolution of need for device therapy in a community heart failure population'. European Journal of Heart Failure, 10 (6):601-607. Available Online [DOI] [Details]
Ryder, M. and Murphy, N.F. and McCaffrey, D. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2008) 'Outpatient intravenous diuretic therapy; potential for marked reduction in hospitalisations for acute decompensated heart failure'. European Journal of Heart Failure, 10 (3):267-272. Available Online [DOI] [Details]
Murphy, N.F. and O'Loughlin, C. and Ledwidge, M. and McCaffrey, D. and McDonald, K. (2007) 'Improvement but no cure of left ventricular systolic dysfunction in treated heart failure patients'. European Journal of Heart Failure, 9 (12):1196-1204. Available Online [DOI] [Details]
Murphy, N. and Mockler, M. and Ryder, M. and Ledwidge, M. and McDonald, K. (2007) 'Decompensation of Chronic Heart Failure Associated With Pregabalin in Patients With Neuropathic Pain'. Journal of Cardiac Failure, 13 (3):227-229. Available Online [DOI] [Details]
Travers, B. and O'Loughlin, C. and Murphy, N.F. and Ryder, M. and Conlon, C. and Ledwidge, M. and McDonald, K. (2007) 'Fluid Restriction in the Management of Decompensated Heart Failure: No Impact on Time to Clinical Stability'. Journal of Cardiac Failure, 13 (2):128-132. Available Online [DOI] [Details]
Ponikowski, P. and Anker, S.D. and Szachniewicz, J. and Okonko, D. and Ledwidge, M. and Zymlinski, R. and Ryan, E. and Wasserman, S.M. and Baker, N. and Rosser, D. and Rosen, S.D. and Poole-Wilson, P.A. and Banasiak, W. and Coats, A.J.S. and McDonald, K. (2007) 'Effect of Darbepoetin Alfa on Exercise Tolerance in Anemic Patients With Symptomatic Chronic Heart Failure. A Randomized, Double-Blind, Placebo-Controlled Trial'. Journal of the American College of Cardiology, 49 (7):753-762. Available Online [DOI] [Details]
McDonald, K. and Conlon, C. and Ledwidge, M. (2007) 'Disease management programs for heart failure: Not just for the 'sick' heart failure population'. European Journal of Heart Failure, 9 (2):113-117. Available Online [DOI] [Details]
O'Hanlon, R. and O'Shea, P. and Ledwidge, M. and O'Loughlin, C. and Lange, S. and Conlon, C. and Phelan, D. and Cunningham, S. and McDonald, K. (2007) 'The Biologic Variability of B-Type Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide in Stable Heart Failure Patients'. Journal of Cardiac Failure, 13 (1):50-55. Available Online [DOI] [Details]
Martos, R. and Baugh, J. and Ledwidge, M. and O'Loughlin, C. and Conlon, C. and Patle, A. and Donnelly, S.C. and McDonald, K. (2007) 'Diastolic heart failure: Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 (7):888-895. Available Online [DOI] [Details]
Karuppiah, S. and Graham, F. and Ledwidge, M. and Conlon, C. and Cahill, J. and O'Loughlin, C. and McManus, J. and McDonald, K. (2006) 'Elevated BNP with normal systolic function in asymptomatic individuals at-risk for heart failure: A marker of diastolic dysfunction and clinical risk'. Irish Journal of Medical Science, 175 (4):5-13. Available Online [Details]
Conlon, C. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2006) 'Community direct access service for early detection and treatment of clinical deterioration: Effectiveness and impact on the workload pattern of a hospital-based heart failure unit'. Disease Management and Health Outcomes, 14 (3):185-190. Available Online [DOI] [Details]
Cahill, J.M. and Ryan, E. and Travers, B. and Ryder, M. and Ledwidge, M. and McDonald, K. (2006) 'Progression of preserved systolic function heart failure to systolic dysfunction - A natural history study'. International Journal of Cardiology, 106 (1):95-102. Available Online [DOI] [Details]
Lewin, J. and Ledwidge, M. and O'Loughlin, C. and McNally, C. and McDonald, K. (2005) 'Clinical deterioration in established heart failure: What is the value of BNP and weight gain in aiding diagnosis?'. European Journal of Heart Failure, 7 (6):953-957. Available Online [DOI] [Details]
Ledwidge, M. and McDonald, K. (2005) 'Prevention of heart failure: Further insight from B-type natriuretic peptide'. British Journal of Cardiology, 12 (3):175-178. Available Online [Details]
Ledwidge, M. and Ryan, E. and O'Loughlin, C. and Ryder, M. and Travers, B. and Kieran, E. and Walsh, A. and McDonald, K. (2005) 'Heart failure care in a hospital unit: A comparison of standard 3-month and extended 6-month programs'. European Journal of Heart Failure, 7 (3 SPEC. ISS):385-391. Available Online [DOI] [Details]
Ryan, E. and Devlin, M. and Prendiville, T. and Ledwidge, M. and McDonald, K. (2004) 'The prevalence and natural history of anaemia in an optimally treated heart failure population'. British Journal of Cardiology, 11 (5):369-375. Available Online [Details]
Ledwidge, M. and Travers, B. and Ryder, M. and Ryan, E. and McDonald, K. (2004) 'Specialist care of heart failure improves appropriate pharmacotherapy at the expense of greater polypharmacy and drug-interactions'. European Journal of Heart Failure, 6 (2):235-243. Available Online [DOI] [Details]
Ryder, M. and Travers, B. and Ledwidge, M. and McDonald, K. (2003) 'Multidisciplinary care of heart failure: What have we learned and where can we improve?'. European Journal of Cardiovascular Nursing, 2 (4):247-249. Available Online [DOI] [Details]
Ryder, M. and Travers, B. and Timmons, L. and Ledwidge, M. and McDonald, K. (2003) 'Specialist nurse supervised in-hospital titration to target dose ACE inhibitor - Is it safe and feasible in a community heart failure population?'. European Journal of Cardiovascular Nursing, 2 (3):183-188. Available Online [DOI] [Details]
Ledwidge, M. and Barry, M. and Cahill, J. and Ryan, E. and Maurer, B. and Ryder, M. and Travers, B. and Timmons, L. and McDonald, K. (2003) 'Is multidisciplinary care of heart failure cost-beneficial when combined with optimal medical care?'. European Journal of Heart Failure, 5 (3):381-389. Available Online [DOI] [Details]
McDonald, K. and Ledwidge, M. (2003) 'Heart failure management programs: Can we afford to ignore the inpatient phase of care?'. Journal of Cardiac Failure, 9 (4):258-262. Available Online [DOI] [Details]
McDonald, K. and Ledwidge, M. and Cahill, J. and Quigley, P. and Maurer, B. and Travers, B. and Ryder, M. and Kieran, E. and Timmons, L. and Ryan, E. (2002) 'Heart failure management: Multidisciplinary care has intrinsic benefit above the optimization of medical care'. Journal of Cardiac Failure, 8 (3):142-148. Available Online [DOI] [Details]
McDonald, K. and Ledwidge, M. and Cahill, J. and Kelly, J. and Quigley, P. and Maurer, B. and Begley, F. and Ryder, M. and Travers, B. and Timmons, L. and Burke, T. (2001) 'Elimination of early rehospitalization in a randomized, controlled trial of multidisciplinary care in a high-risk, elderly heart failure population: The potential contributions of specialist care, clinical stability and optimal angiotensin-converting enzyme inhibitor dose at discharge'. European Journal of Heart Failure, 3 (2):209-215. Available Online [DOI] [Details]
Finan, A. and Clarke, T.A. and Matthews, T.G. and Ledwidge, M. and Gillan, J. and Barry-Kinsella, C. and McKenna, P. (1999) 'Strategies for reduction of neonatal mortality'. Irish Journal of Medical Science, 168 (4):265-267. Available Online [Details]
Finan, A. and Ledwidge, M. and Clarke, T. and Matthews, T. and Gillan, J. and Gleeson, R. and Mckenna, P. and O'Regan, M. (1998) 'Perinatal factors influencing survival in extremely low-birthweight infants'. Journal of Obstetrics and Gynaecology, 18 (3):227-230. Available Online [DOI] [Details]
Ledwidge, M. and Fox, G. and Matthews, T. (1998) 'Neurocardiogenic syncope: A model for SIDS'. Archives of Disease in Childhood, 78 (5):481-483. Available Online [Details]