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Neil Gerard Docherty

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Biography

Following undergraduate studies in Biochemistry and Immunology at University of Aberdeen, Scotland, I undertook a Ph.D. at The Department of Physiology and Pharmacology, University of Salamanca, Spain, studying  inflammation and fibrosis in the setting of acute renal failure.

I subsequently undertook a post-doctoral fellowship at The School of Medicine and Medical Sciences at University College Dublin (UCD) examining functional, inflammatory and fibrotic aspects of renal injury in obstructive nephropathy.

From 2007-2009, also at UCD, I led MD research projects focused on chronic inflammation and tissue remodelling in obstructive nephropathy, inflammatory bowel disease and glaucoma whilst building experience in teaching and learning.

In 2009, I was appointed to a lectureship at the Department of Physiology, Trinity College Dublin charged with the prospective design and implementation of Human Health & Disease an integrated 4-year programme of undergraduate study in applied biomedical science.

In late 2013 I rejoined faculty at the UCD School of Medicine and Medical Sciences as a Lecturer in Pathology and Principal Investigator at the Diabetes Complications Research Centre where I co-lead research into the surgical treatment of obesity, diabetes and diabetic complications with Professor Carel le Roux.

Professional

Honours and Awards

Year: 2012.
Title: Provost's special commendation for teaching excellence
         

Committees

Committee : Medicine Degree Committee 1
             

Publications

 

Book Chapters

Docherty NG, O'Connell PR; (2009) 'TNF a neutralization in the medical management of Crohn's Disease' In: Columbus F (eds). Tumour Necrosis Factor Alpha. New York: Nova Science. [Details]
Neil G Docherty and John M Fitzpatrick; (2009) 'Upper Urinary Tract Obstruction' In: Mundy A, Fitzpatrick JM, Neal D and George JR (eds). The Scientific Basis of Urology 3rd Edition. London: Taylor and Francis. [Details]
 

Peer Reviewed Journals

Docherty, N. G., Perez-Barriocanal, F., Balboa, N. E., Lopez-Novoa, J. M. (2002) 'Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney'. Ren Fail, 24 (4):391-406. Available Online [Details]
Rodriguez-Pena, A., Eleno, N., Duwell, A., Arevalo, M., Perez-Barriocanal, F., Flores, O., Docherty, N., Bernabeu, C., Letarte, M., Lopez-Novoa, J. M. (2002) 'Endoglin upregulation during experimental renal interstitial fibrosis in mice'. Hypertension, 40 (5):713-20. Available Online [Details]
Prieto, M., Rodriguez-Pena, A. B., Duwel, A., Rivas, J. V., Docherty, N., Perez-Barriocanal, F., Arevalo, M., Vary, C. P., Bernabeu, C., Lopez-Novoa, J. M., Eleno, N. (2005) 'Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats'. J Physiol Biochem, 61 (3):457-67. Available Online [Details]
Docherty, N. G., Lopez-Novoa, J. M., Arevalo, M., Duwel, A., Rodriguez-Pena, A., Perez-Barriocanal, F., Bernabeu, C., Eleno, N. (2006) 'Endoglin regulates renal ischaemia-reperfusion injury'. Nephrol Dial Transplant, 21 (8):2106-19. Available Online [Details]
Docherty, N. G., O'Sullivan, O. E., Healy, D. A., Fitzpatrick, J. M., Watson, R. W. (2006) 'Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction'. Am J Physiol Renal Physiol, 290 (1). Available Online [Details]
Docherty, N. G., O'Sullivan, O. E., Healy, D. A., Murphy, M., O'Neill A, J., Fitzpatrick, J. M., Watson, R. W. (2006) 'TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. Am J Physiol Renal Physiol, 290 (5). Available Online [Details]
Healy, D. A., Daly, P. J., Docherty, N. G., Murphy, M., Fitzpatrick, J. M., Watson, R. W. (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. J Am Soc Nephrol, 17 (3):805-12. Available Online [Details]
Burke, J. P., Mulsow, J. J., O'Keane, C., Docherty, N. G., Watson, R. W., O'Connell, P. R. (2007) 'Fibrogenesis in Crohn's disease'. Am J Gastroenterol, 102 (2):439-48. Available Online [Details]
Docherty, N. G., Morales, A. I., Lopez Novoa, J. M., Perez Barriocanal, F. (2007) '[The transition of epithelial cells to fibromyoblasts. Mechanisms involved and its possible relationship with renal fibrosis]'. Nefrologia, 27 (6):681-8. Available Online [Details]
McGuire, B. B., Watson, R. W., Perez-Barriocanal, F., Fitzpatrick, J. M., Docherty, N. G. (2007) 'Gender differences in the renin-angiotensin and nitric oxide systems: relevance in the normal and diseased kidney'. Kidney Blood Press Res, 30 (2):67-80. Available Online [Details]
Burke, J. P., Ferrante, M., Dejaegher, K., Watson, R. W., Docherty, N. G., De Hertogh, G., Vermeire, S., Rutgeerts, P., D'Hoore, A., Penninckx, F., Geboes, K., Van Assche, G., O'Connell, P. R. (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflamm Bowel Dis, 14 (9):1197-204. Available Online [Details]
Murphy, M., Docherty, N. G., Griffin, B., Howlin, J., McArdle, E., McMahon, R., Schmid, H., Kretzler, M., Droguett, A., Mezzano, S., Brady, H. R., Furlong, F., Godson, C., Martin, F. (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J Am Soc Nephrol, 19 (9):1672-80. Available Online [Details]
Quinlan, M. R., Docherty, N. G., Watson, R. W., Fitzpatrick, J. M. (2008) 'Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction'. Am J Physiol Renal Physiol, 295 (1). Available Online [Details]
Burke, J. P., Watson, R. W., Murphy, M., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. Br J Surg, 96 (5):541-51. Available Online [Details]
Coffey, J. C., Docherty, N. G., O'Connell, P. R. (2009) 'Hydrogen sulphide: an increasing need for scientific equipoise'. Gastroenterology, 137 (6). Available Online [Details]
Coffey, J. C., Rowan, F., Burke, J., Dochery, N. G., Kirwan, W. O., O'Connell, P. R. (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. Am J Gastroenterol, 104 (4):1013-23. Available Online [Details]
Coffey, J. C.,Rowan, F.,Burke, J.,Dochery, N. G.,Kirwan, W. O.,O'Connell, P. R.; (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. Am J Gastroenterol, 104 (44):1013-231013. Available Online [DOI] [Details]
Daly, P. J., Docherty, N. G., Healy, D. A., McGuire, B. B., Fitzpatrick, J. M., Watson, R. W. (2009) 'The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage'. BJU Int, 103 (2):254-9. Available Online [Details]
Docherty, N. G., Calvo, I. F., Quinlan, M. R., Perez-Barriocanal, F., McGuire, B. B., Fitzpatrick, J. M., Watson, R. W. (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney Int, 75 (2):205-13. Available Online [Details]
Rowan, F. E., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. Br J Surg, 96 (2):151-8. Available Online [Details]
Rowan, F. E.,Docherty, N. G.,Coffey, J. C.,O'Connell, P. R.; (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. Br J Surg, 96 (22):151-8151. Available Online [Details]
Burke, J. P., Cunningham, M. F., Watson, R. W., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. Br J Surg, 97 (7):1126-34. Available Online [Details]
Burke, J. P., Watson, R. W., Mulsow, J. J., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. Br J Surg, 97 (6):892-901. Available Online [Details]
Cunningham, M. F., Docherty, N. G., Burke, J. P., O'Connell, P. R. (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. Am J Physiol Gastrointest Liver Physiol, 299 (2). Available Online [Details]
Cunningham, M. F., Docherty, N. G., Coffey, J. C., Burke, J. P., O'Connell, P. R. (2010) 'Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis'. World J Surg, 34 (7):1615-26. Available Online [Details]
Quinlan, M. R., Cronin, P., Daly, P. J., Watson, R. W., Manucha, W., Docherty, N. G., Fitzpatrick, J. M. (2010) 'A gender comparison of postobstructive injury in the rat kidney'. Kidney Blood Press Res, 33 (4):266-73. Available Online [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, B., Calvin Coffey, J., O'Connell, P. R. (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Dis Colon Rectum, 53 (11):1530-6. Available Online [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, T. B., Coffey, J. C., O'Connell, P. R. (2010) 'Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis'. Ann Surg, 252 (5):869-75. Available Online [Details]
Borgeson, E., Docherty, N. G., Murphy, M., Rodgers, K., Ryan, A., O'Sullivan, T. P., Guiry, P. J., Goldschmeding, R., Higgins, D. F., Godson, C. (2011) 'Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis'. FASEB J, 25 (9):2967-79. Available Online [Details]
Burke, J. P., Cunningham, M. F., Sweeney, C., Docherty, N. G., O'Connell, P. R. (2011) 'N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration'. Inflamm Bowel Dis, 17 (8):1665-73. Available Online [Details]
Docherty, N. G., Godson, C. (2011) 'Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast'. Kidney Int, 80 (10):1014-6. Available Online [Details]
Hickey, F. B., Corcoran, J. B., Docherty, N. G., Griffin, B., Bhreathnach, U., Furlong, F., Martin, F., Godson, C., Murphy, M. (2011) 'IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1alpha'. J Am Soc Nephrol, 22 (8):1475-85. Available Online [Details]
McElnea, E. M., Quill, B., Docherty, N. G., Irnaten, M., Siah, W. F., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2011) 'Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors'. Mol Vis, 17 :1182-91. Available Online [Details]
Medani, M., Collins, D., Docherty, N. G., Baird, A. W., O'Connell, P. R., Winter, D. C. (2011) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflamm Bowel Dis, 17 (7):1620-5. Available Online [Details]
Quill, B., Docherty, N. G., Clark, A. F., O'Brien, C. J. (2011) 'The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells'. Invest Ophthalmol Vis Sci, 52 (3):1908-15. Available Online [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, T. B., Coffey, J. C., O'Connell, P. R. (2011) 'Ileal pouch microbial diversity'. Ann Surg, 254 (4). Available Online [Details]
Mazzei, L. J., Garcia, I. M., Altamirano, L., Docherty, N. G., Manucha, W. (2012) 'Rosuvastatin preserves renal structure following unilateral ureteric obstruction in the neonatal rat'. Am J Nephrol, 35 (2):103-13. Available Online [Details]
Brennan, E. P., Nolan, K. A., Borgeson, E., Gough, O. S., McEvoy, C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier, D. M., Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A. P., Martin, F., Godson, C., Genie Consortium (2013) 'Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFbetaR1'. J Am Soc Nephrol, 24 (4):627-37. Available Online [Details]
Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A., Bhreathnach, U., Borgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F., Martin, F., Godson, C., Murphy, M. (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-beta1-induced fibrotic responses'. Biochim Biophys Acta, 1833 (8):1969-78. Available Online [Details]
Irnaten, M., Barry, R. C., Wallace, D. M., Docherty, N. G., Quill, B., Clark, A. F., O'Brien, C. J. (2013) 'Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells'. Exp Eye Res, 115 :224-9. Available Online [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Physiological and pathophysiological signalling between the gut and the kidney: role in diabetic kidney disease'. Exp Physiol, 99 (9):1138-9. Available Online [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'. Exp Physiol, 99 (9):1146-53. Available Online [Details]
Docherty, N. G., Murphy, M., Martin, F., Brennan, E. P., Godson, C. (2014) 'Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-beta1-associated profibrotic responses in diabetic kidney disease'. Exp Physiol, 99 (9):1154-62. Available Online [Details]
Jackson, S., le Roux, C. W., Docherty, N. G. (2014) 'Bariatric surgery and microvascular complications of type 2 diabetes mellitus'. Curr Atheroscler Rep, 16 (11). Available Online [Details]
Lennon, G., Balfe, A., Bambury, N., Lavelle, A., Maguire, A., Docherty, N. G., Coffey, J. C., Winter, D. C., Sheahan, K., O'Connell, P. R. (2014) 'Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis'. Colorectal Dis, 16 (5). Available Online [Details]
McElnea, E. M., Hughes, E., McGoldrick, A., McCann, A., Quill, B., Docherty, N., Irnaten, M., Farrell, M., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmol, 14 . Available Online [Details]
Rodriguez-Pena, A. B., Fuentes-Calvo, I., Docherty, N. G., Arevalo, M., Grande, M. T., Eleno, N., Perez-Barriocanal, F., Lopez-Novoa, J. M. (2014) 'Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy'. Biomed Res Int, 2014 . Available Online [Details]
Vallon, V., Docherty, N. G. (2014) 'Intestinal regulation of urinary sodium excretion and the pathophysiology of diabetic kidney disease: a focus on glucagon-like peptide 1 and dipeptidyl peptidase 4'. Exp Physiol, 99 (9):1140-5. Available Online [Details]
Abegg, K., Corteville, C., Docherty, N. G., Boza, C., Lutz, T. A., Munoz, R., le Roux, C. W. (2015) 'Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats'. Am J Physiol Regul Integr Comp Physiol, 308 (4). Available Online [Details]
Docherty, N. G., Canney, A. L., le Roux, C. W. (2015) 'Weight Loss Interventions and Progression of Diabetic Kidney Disease'. Curr Diab Rep, 15 (8). Available Online [Details]
Lavelle, A., Lennon, G., O'Sullivan, O., Docherty, N., Balfe, A., Maguire, A., Mulcahy, H. E., Doherty, G., O'Donoghue, D., Hyland, J., Ross, R. P., Coffey, J. C., Sheahan, K., Cotter, P. D., Shanahan, F., Winter, D. C., O'Connell, P. R. (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut, . Available Online [Details]
Quill, B., Irnaten, M., Docherty, N. G., McElnea, E. M., Wallace, D. M., Clark, A. F., O'Brien, C. J. (2015) 'Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells'. Br J Ophthalmol, 99 (7):1009-14. Available Online [Details]
Tham, J. C., le Roux, C. W., Docherty, N. G. (2015) 'Cardiovascular, renal and overall health outcomes after bariatric surgery'. Curr Cardiol Rep, 17 (5). Available Online [Details]
                                                                                             

Research

Research Interests

 In collaboration with my colleague Professor Carel le Roux, I co-lead research into the surgical treatment of obesity, diabetes and diabetic complications.
 

Research Projects

Sponsor : University College Dublin (UCD)
Title : Soluble TNFR1 as a Predictor of Diabetic Kidney Disease in Obesity and a Potential Tool for Guiding Clincal Decisions and Resource Allocation: Preliminary Interrogation in The Swedish Obese Subjects (SOS) Study Dataset
Start Date / End Date : 01-APR-14 / 30-SEP-15
Sponsor : The Wellcome Trust (WT)
Title : Effect of Roux-en-Y Gastric Bypass Surgery on Renal Macrophage Phenotype in Zucker Diabetic Fatty Rats
Start Date / End Date : 02-JUN-14 / 31-JUL-14
Sponsor : University College Dublin (UCD)
Title : Start-up Funds
Start Date / End Date : 01-MAR-14 / 28-FEB-17
Sponsor : University College Dublin Foundation Ltd.
Title : Research Activities
Start Date / End Date : 01-NOV-14 / 31-OCT-15

Recent Postgraduates

Quill, B.                     Glaucoma                                          M.D. (March 2012)

Cunningham, M.        Crohn¿s disease                                 M.D. (August 2011)

Rowan, F.                  Ulcerative colitis                                M.D. ( June 2009)

Quinlan, M.R.             Obstructive nephropathy                   M.D. (Feb 2009)

O¿Sullivan, O.             Obstructive nephropathy                   M.Ch. (May 2008)

McGuire, B.                Obstructive nephropathy                   M.D. (Dec. 2007)

Current Postgraduate Students

Sabrina Jackson, Master of Science (MSc)   -   Thesis Supervisor
Aoife Canney, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201400   PATH30010     Pathology: Systematic Pathology (Radiog)
201400   PATH30080     Pathology: Mechanisms of Disease (MED)
201400   PATH30070     Pathology: Mechanisms of Disease (Rad)
       

Collaborators

Internal Collaborators

Professor Carel le Roux
Professor Catherine Godson
Dr. Aurelie Fabre
Dr. John Crean
 

External Collaborators

Dr Walter Manucha (Universidad Nacional de Cuyo, Argentina)
Dr. Lars Fandriks (University of Gothenburg)
Dr. Kanishka Nilaweera (TEAGASC)