Researchers at UCD


Paul Crossey


School Of Medicine & Medical Science
Conway Institute
Dublin 4

Tel: +353 1 7166781




Association: DiabetesUK, Function/Role: Member
Association: British Society for Endocrinology, Function/Role: Member
Association: Biochemical Society, Function/Role: Member
Association: Physiological Society, Function/Role: Member
Association: European Association for the Study of Diabetes (EASD), Function/Role: Member


Year 1992 Institution: NUI Galway, IRL
Qualification: PhD Subject:



Peer Reviewed Journals

Duncan E, Crossey PA, Walker S, Anilkumar N, Poston L, Douglas G, Ezzat V, Wheatcroft SB, Shah AM and Kearney MT ; (2009) 'The effects of endothelium specific insulin resistance on endothelial function in vivo'. Diabetes, 57 (12):3307-3314Insulin resi. [Details]
Wheatcroft SB, Kearney MT, Shah AM, Ezzat VA, Miell JR, Modo M, Williams SC, Cawthorn WP, Medina-Gomez G, Vidal-Puig A, Sethi JK, Crossey PA; (2007) 'IGF-binding protein-2 protects against the development of obesity and insulin resistance'. Diabetes, 56 (2):285-294. [Details]
Wheatcroft SB, Shah AM, Li JM, Duncan E, Noronha BT, Crossey PA, Kearney MT; (2004) 'Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor'. Diabetes, 53 (10):2645-2652. [Details]
Wheatcroft SB, Kearney MT, Shah AM, Grieve DJ, Williams IL, Miell JP, Crossey PA; (2003) 'Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1'. Diabetes, 52 (8):2075-2082. [Details]
Crossey PA, Pillai CC, Miell JP.; (2002) 'Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice'. Journal of Clinical Investigation, 110 (3):411-418. [Details]
Crossey PA, Jones JS and Miell JP ; (2000) 'Dysregulation of the insulin/insulin like growth factor binding protein- 1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance'. Diabetes, 49 (3). [Details]
Holt RIG, Crossey PA, Jones JS, Baker AJ, Portmann B and Miell JP ; (1997) 'Hepatic growth hormone receptor, insulin like growth factor-I and insulin lilke growth factor binding protein messenger RNA expression in pediatric liver disease'. Hepatology, 26 (61):600-1606. [Details]
RIG, Baker AJ, Jones JS, Crossey PA, Stone NM, Preedy VR and Miell JP ; (1996) 'Differential effects of malnutrition, bile duct ligation and galactosamine injection in young rats on serum levels and gene expression of IGF-binding proteins'. Journal of Hepatology, 149 (3):465-472. [Details]
Zbar B, Kishida T, Chen F, Schmidt L, Maher ER, Richards FM, Crossey PA, WebsterAR, Affara NA, Ferguson-Smith MA ; (1996) 'Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe and Japan''. Human Mutation, 8 (4):348-357. [Details]
Maher ER, Webster AR, Richards FM, Green JS, Crossey PA, Payne SJ and Moore AT; (1996) 'Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations'. Journal of Medical Genetics, 33 (4):328-332. [Details]
Ritter M M, Frilling A, Crossey PA, Hoppner W, Maher EM, Ponder BAJ and Engelhardt ; (1996) ''Isolated Familial Pheochromocytoma as a variant of von Hippel Lindau Disease'. Journal of Clinical Endocrinology and Metabolism, 81 (3):1035-1037. [Details]
Neumann HP, Eng C, Mulligan LM, Glavac D, Zauner I, Ponder BAJ, Crossey PA, Maher ER, and Brauch H ; (1995) 'Consequences of direct genetic testing for germline mutations in the clinical management of families with Multiple Endocrine Neoplasia type 2'. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 274 (14):1149-1151. [Details]
Crossey PA, Eng C, Ginalska-Malinowska M, Lennard TWJ, Wheeler DC, Ponder BAJ and Maher ER ; (1995) 'Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma'. Journal of Medical Genetics, 32 (11):885-886. [Details]
Eng C, Crossey PA, Mulligan LM, Healey CS, Houghton C, Prowse A, Chew SL, Dahia PLM, Toledo SPA, Smith DP, Maher ER and Ponder BAJ ; (1995) 'Mutations in the RET protooncogene and the von Hippel-Lindau tumour suppressor gene in sporadic and syndromic pheochromocytomas'. JOURNAL OF MEDICAL GENETICS, 32 (12):934-937. [Details]
Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek MM, Crossey PA, Richards FM, Cairns P, Affara NA, Ferguson Smith MA, Buys CH and Maher ER ; (1994) 'Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in nonfamilial clear cell renal carcinoma''. Human Molecular Genetics, 3 (12):2169-2173. [Details]
Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA and Maher ER ; (1994) 'Molecular genetic investigation of sporadic renal cell carcinoma:analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22'. 69 (2):230-234. [Details]
Crossey PA, Richards FM, Foster K, Prowse A, Green JS, Latif F, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA and Maher ER ; (1994) ''Identification of intragenic mutations in the von Hippel-Lindau disease gene and correlation with disease phenotype'. Human Molecular Genetics, 3 (8):1303-1308. [Details]
Richards FM, Crossey PA, Phipps ME, Foster K, Latif F, Evans G, Sampson J, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA and Maher ER ; (1994) 'Detailed mapping of germline deletions of the von Hippel-Lindau disease tumour suppressor gene'. Human Molecular Genetics, 3 (4):595-598. [Details]
Crossey PA, Foster K, Richards FM, Phipps ME, Latif F, Tory K, Jones MH, Bentley E, Kumar R, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA and Maher ER ; (1994) 'Molecular genetic investigation of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours'. Human Genetics, 93 (1):53-58. [Details]
Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Hua L, Wei MH, Chen F, Glenn G, Choyke P, McClellan M, Walther M, Weng Y, Duan RD-S, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, LePaslier D, Chumakov I, Cohen D, Chinault AC, Maher ER Linehan WM, Zbar B and Lerman MI ; (1993) 'Identification of the von Hippel-Lindau disease tumour suppressor gene'. Science, 260 :1317-1320. [Details]
Richards FM, Phipps ME, Latif F, Yao M, Crossey PA, Foster K, Linehan WM, Affara NA, Lerman MI, Zbar B, Ferguson-Smith MA and Maher ER ; (1993) 'Mapping the von Hippel-Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis'. Human Molecular Genetics, 2 (7):879-882. [Details]
Crossey PA, Maher ER, Jones MH, Richards FM, Latif F, Phipps ME, Lush M, Foster K, Green JS, Oostra B, Yates JRW, Linehan WM, Affara NA, Lerman M, Zbar B, Nakamura Y, and Ferguson-Smith MA ; (1993) 'Genetic linkage between von Hippel-Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus'. Human Molecular Genetics, 2 (3):279-282. [Details]
Richards FM, Maher ER, Latif F, Phipps ME, Tory K, Lush M, Crossey PA, Oostra B, Gustavson KH, Green J, Turner G, Yates JRW, Linehan WM, Affara NA, Lerman M, Zbar B and Ferguson-Smith MA ; (1993) 'Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene'. JOURNAL OF MEDICAL GENETICS, 30 (2):104-107. [Details]


Research Interests

Insulin, growth hormone (GH) and IGF-I comprise an important endocrine axis involved in regulating growth and metabolism. Dysregulation of this axis is a consistent pathogenic finding in disorders of insulin deficiency (type 1 diabets) and resistance (type 2 diabetes). My research interests are focused on a family of IGF binding proteins (IGFBPs) which regulate IGF bioavailability and thus bioactivity. One of these IGFBPs, IGFBP-1, is directly regulated by insulin in a manner that suggests its plays a key role in co-ordinating the metabolic actions of IGF-I and insulin in relation to nutritional status. Reduced IGF-I bioavailability is a feature of type 1 and type 2 diabetes and there is growing evidence that this is an important factor in the pathophysiology of these disorders. Our research strategy utilises in vivo methodologies in genetically modified mouse models to derive important insights into the role of IGF-I in diabetes and its sequelae and to explore if manipulation of the growth hormone/IGF-I axis may be a viable therapeutic approach for treatment of these disorders.

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Investigation of the antiatherogenic actions of insulin like growth factor binding protein 1 in vivo
Start Date / End Date : 01-OCT-09 / 30-SEP-13
Sponsor : University College Dublin (UCD)
Title : The Role of the Insulin Like Growth Factors and their Binding Proteins in the Development of Diabetes and its Complications
Start Date / End Date : 01-MAR-08 / 31-DEC-10
Sponsor : University College Dublin (UCD)
Title : The Insulin Like Growth Factors and their Binding Proteins in Diabetic Nephropathy
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin (UCD)
Title : The Role of Gremlin in Liver Fibrosis
Start Date / End Date : 26-JUN-08 / 01-DEC-09

Current Postgraduate Students

Jennifer Allen, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Daniel Jones, Doctor of Philosophy (PhD)   -   Thesis Supervisor


Teaching Philosophy

Module Co-ordinator

PHYS30040 Endocrine and Reproductive Endocrinology
PHYS30180  Integrated Animal Physiology

Module Contributor
MDSA20030 Endocrine Biology
MDSA30210 Endocrine System in Health and Disease
PHYS20020 Neurophysiology - Sensing and Responding to the Internal and External Environment
MDSA20210 and 20220 - Molecules in Medicine

Recent Postgraduate Students
Claire Pillai (PhD)
Stephen Wheatcroft (PhD)
Lei Teng (MSc)

Current Postgraduate Students
Daniel Jones
Jennifer Allen

Modules Coordinated

201200   PHYS30180     Physiology: Integrated Animal Physiology
201200   MDSA20030     Medicine Systems One: Endocrine Biology
201200   PHYS30040     Physiology: Endocrine/Reproductive Phys