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Seamas Donnelly

School of Medicine & Medical Science
Medicine, St Vincent's University Hospital, Education & Research Centre (ERC), Elm Park, Dublin 4, Ireland.

Tel: +353 1 716353 (0)1 221 4930
Email: seamas.donnelly@ucd.ie

Biography

Professor Seamas Donnelly  is an international leader in Translational Medicine and his research epitomizes classical bench to bedside on an international stage.  The work of his research group is leading to novel therapies in respiratory disease, particularly in Asthma, COPD and Sarcoidosis. 

A medical graduate of University College Galway (UCG), he successfully competed previously for prestigious Wellcome Trust Fellowships at the University of Edinburgh and the Picower Institute in New York, an Institute affiliated to Rockefeller University.  Returning to Ireland, he was one of the first clinicians to be awarded a Science Foundation Ireland (SFI) Principal Investigator Programme grant award which was recently renewed for a further 5 years.  This work has focused on the development of novel small molecular-weight anti-inflammatory agents targeting chronic inflammatory diseases particularly pertaining to the lung.  He is a co-applicant on the recently awarded Wellcome Trust/HRB Dublin Clinical Research Facility.

In 2010 he was awarded an Honorary Professorship by the University of Edinburgh, The University of Edinburgh is currently ranked among the top 20 universities in the world and following the recent UK Research Assessment Exercise, has been ranked number 1 with regards to medical research.  The citation from Edinburgh University recognizes Professor Donnelly¿s as an international leader in medical research and how his research epitomizes classical bench to bedside on an international stage. 

 

Professional

Honours and Awards

Year: 2001.
Title: Presidents Research Award
Year: 2010.
Title: Award of Honorary Professorship
       

Conference Contributions

Barragry R, Fitzsimon N, Plant B, Chappell SL, Gallagher CG, Daly L, Morgan K, Donnelly SC.; (2007) Association Analysis of AAT, TNF, ACT, GCSC and GCSR Polymorphisms (SNPs) with Cystic Fibrosis (CF) in an Irish Cohort. [Poster Presentation], American Thoracic Society 103rd International Conference, San Francisco , 18-JUN-07 - 23-JUN-07.
 

Employment

Employer: University of Edinburgh
Position: Lecturer
Employer: University of Edinburgh
Position: Senior Lecturer
Employer: University College Dublin
Position: Lecturer & Consultant Physician

Education

Year 1984 Institution: --none--
Qualification: MB, BCh, BAO Subject: --none--
Year 1993 Institution:
Qualification: MD Subject:
Year 1984 Institution:
Qualification: MB Subject:
Year 1999 Institution: Royal College of Physicians, Ir
Qualification: FRCPI Subject:
   

Outreach Activities


Director , School of Medicine Primary School, Outreach Programme - Exciting children about science and medicine

Board of Directors - Irish Charity - Joe Kavanagh Foundation 2009 - to present day.

Medical Director - Irish Charity -  iSARC - Sarcoidosis support network, 2004 - to present day.

Medical Director - Irish Charity - Irish Lung Foundation 2001-2008

   

Publications

     

Peer Reviewed Journals

Chappell, SL,Daly, L,Lotya, J,Alsaegh, A,Guetta-Baranes, T,Roca, J,Rabinovich, R,Morgan, K,Millar, AB,Donnelly, SC,Keatings, V,MacNee, W,Stolk, J,Hiemstra, PS,Miniati, M,Monti, S,O'Connor, CM,Kalsheker, N; (2011) 'The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study'. BMC Medical Genetics, 12 . [DOI] [Details]
Haq, I,Chappell, S,Johnson, SR,Lotya, J,Daly, L,Morgan, K,Guetta-Baranes, T,Roca, J,Rabinovich, R,Millar, AB,Donnelly, SC,Keatings, V,MacNee, W,Stolk, J,Hiemstra, PS,Miniati, M,Monti, S,O'Connor, CM,Kalsheker, N; (2010) 'Association of MMP-12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12 in a European population'. Gene, 11 . [DOI] [Details]
Kevill, KA,Bhandari, V,Kettunen, M,Leng, L,Fan, J,Mizue, Y,Dzuira, JD,Reyes-Mugica, M,McDonald, CL,Baugh, JA,O'Connor, CL,Aghai, ZH,Donnelly, SC,Bazzy-Asaad, A,Bucala, RJ; (2008) 'A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome'. J IMMUNOL, 180 :601-608. [Details]
Conroy H, Mawhinney L, Donnelly SC; (2010) 'Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link'. QJM : monthly journal of the Association of Physicians, 103 (11):831-836. [DOI] [Details]
Govender P, Dunn MJ, Donnelly SC ; (2009) 'Proteomics and the lung: Analysis of bronchoalveolar lavage fluid'. Proteomics Clinical Applications, 2 :1044-1051. [Details]
Reid CJ, Thompson L, Donnelly S, Deaton CM, Marlin DJ, Carrington SD, Irwin JA; (2009) 'The activity and expression of chitinase in the equine lung and its activity in normal horses and animals with recurrent airway obstruction'. Research in Veterinary Science, 87 (1):20-25. [DOI] [Details]
Martos, R,Baugh, J,Ledwidge, M,O'Loughlin, C,Murphy, NF,Conlon, C,Patle, A,Donnelly, SC,McDonald, K; (2009) 'Diagnosis of heart failure with preserved ejection fraction: improved accuracy with the use of markers of collagen turnover'. European Journal of Heart Failure, 11 :191-197. [DOI] [Details]
Harte, S.,McNicholas, W. T.,Donnelly, S. C.,Dodd, J. D.; (2008) 'Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults'. Br J Radiol, 81 (972):e295-8. Available Online [Details]
Armstrong, M. E., Gantier, M., Li, L. L., Chung, W. Y., McCann, A., Baugh, J. A., Donnelly, S. C., ; (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. Immunology, 180 (11):7125-7133. [Details]
Armstrong, ME,Gantier, M,Li, LL,Chung, WY,McCann, A,Baugh, JA,Donnelly, SC; (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. J IMMUNOL, 180 :7125-7133. [Details]
Kalsheker N, Chappell S, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Lotya J, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, ; (2008) 'Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD'. EUR RESPIR J, 32 (4):931-937. [DOI] [Details]
Dodd JD, Harte S, McNicholas WT, Donnelly SC, ; (2008) 'Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults'. British Journal of Radiology, 81 (972):1-8. [DOI] [Details]
Kalsheker N, Chappell S, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Lotya J, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, ; (2008) 'Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD'. EUR RESPIR J, 4 (NA):931-937. [DOI] [Details]
Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, Macnee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N.; (2007) 'Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD'. European Respiratory Journal, 30 (4):810-812. [Details]
Foley, S. C.,Hopkins, N. O.,Fitzgerald, M. X.,Donnelly, S. C.,McLoughlin, P.; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respir Med, 101 (7):1549-55. [Details]
Gantier, MP,Baugh, JA,Donnelly, SC; (2007) 'Nuclear transcription of long hairpin RNA triggers innate immune responses'. Cytokine, 27 :789-797. [DOI] [Details]
Govender P, Baugh JA, Pennington SR, Dunn MJ, Donnelly SC.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-388. [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. [Details]
Kalsheker N, Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, Macnee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, ; (2007) 'Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD'. EUR RESPIR J, 4 (NA):810-812. [DOI] [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. Available Online [Details]
Dawson KA, Cedervall T, Lynch I, Foy M, Berggård T, Donnelly SC, Cagney G, Linse S, ; (2007) 'Detailed identification of plasma proteins adsorbed on copolymer nanoparticles'. Angewandte Chemie (International ed. in English), 46 (30):5754-5756. [DOI] [Details]
Dawson KA, Cedervall T, Lynch I, Foy M, Berggård T, Donnelly SC, Cagney G, Linse S, ; (2007) 'Detailed identification of plasma proteins adsorbed on copolymer nanoparticles'. Angewandte Chemie (International ed. in English), 46 (30):5754-5756. [DOI] [Details]
Martos R, Baugh J, Ledwidge M, O'Loughlin C, Conlon C, Patle A, Donnelly S, McDonald K.; (2007) 'Diastolic Heart Failure: Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 :888-895. [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. [Details]
Foley, SC, Hopkins, NO, Fitzgerald, MX, Donnelly, SC, McLoughlin, P, ; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respiratory Medicine, 101 :1549-1555. [Details]
Martos, R; Baugh, J; Ledwidge, M; O'Loughlin, C; Conlon, C; Patle, A; Donnelly, SC; McDonald, K; ; (2007) 'Diastolic heart failure - Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 (7):888-895. [Details]
Plant, BJ; Ghani, S; O'Mahony, MJ; Morgan, L; O'Connor, CM; Morgan, K; Baugh, JA; Donnelly, SC; ; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. European Respiratory Journal, 29 (2):325-329. [Details]
Plant, BJ; Ghani, S; O'Mahony, MJ; Morgan, L; O'Connor, CM; Morgan, K; Baugh, JA; Donnelly, SC; ; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. European Respiratory Journal, 29 (2):325-329. [Details]
Martos, R,Baugh, J,Ledwidge, M,O'Loughlin, C,Conlon, C,Patle, A,Donnelly, SC,McDonald, K; (2007) 'Diastolic heart failure - Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 :888-895. [DOI] [Details]
Bucala, R,Donnelly, SC; (2007) 'Macrophage migration inhibitory factor: A probable link between inflammation and cancer'. Immunity, 26 :281-285. [Details]
Plant, BJ,Ghani, S,O'Mahony, MJ,Morgan, L,O'Connor, CM,Morgan, K,Baugh, JA,Donnelly, SC; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. EUR RESPIR J, 29 :325-329. [DOI] [Details]
Foley, SC,Hopkins, NO,Fitzgerald, MX,Donnelly, SC,McLoughlin, P; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respiratory Medicine, 101 :1549-1555. [DOI] [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. [Details]
Govender P, Baugh JA, Pennington SR, Dunn MJ, Donnelly SC. ; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Review of Proteomics, 4 (3):379-388. [Details]
Foley, S. C.,Hopkins, N. O.,Fitzgerald, M. X.,Donnelly, S. C.,McLoughlin, P.; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respir Med, 101 (7):1549-1555. [Details]
Cedervall, T.,Lynch, I.,Foy, M.,Berggard, T.,Donnelly, S. C.,Cagney, G.,Linse, S.,Dawson, K. A.; (2007) 'Detailed identification of plasma proteins adsorbed on copolymer nanoparticles'. Angew Chem Int Ed Engl, 46 (30):5754-6. [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. [Details]
Bucala, R.,Donnelly, S. C.; (2007) 'Macrophage migration inhibitory factor: a probable link between inflammation and cancer'. Immunity, 26 (3):281-5. [Details]
Chappell, S,Daly, L,Morgan, K,Baranes, TG,Roca, J,Rabinovich, R,Millar, A,Donnelly, SC,Keatings, V,MacNee, W,Stolk, J,Hiemstra, P,Miniati, M,Monti, S,O'Connor, CM,Kalsheker, N; (2006) 'Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease'. Human Mutation, 27 :103-109. [DOI] [Details]
Chappell, S; Daly, L; Morgan, K; Baranes, TG; Roca, J; Rabinovich, R; Millar, A; Donnelly, SC; Keatings, V; MacNee, W; Stolk, J; Hiemstra, PS; Miniati, M; Monti, S; O'Connor, CM; Kalsheker, N; ; (2006) 'The SERPINE2 gene and chronic obstructive pulmonary disease'. American Journal of Human Genetics, 79 (1):184-186. [Details]
Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N.; (2006) 'The SERPINE2 gene and chronic obstructive pulmonary disease'. American Journal of Human Genetics, 79 (1):184-186. [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Martos, R; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure'. European Heart Journal, 27 (NA):844-844. [Details]
Martos, R; Patle, A; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population'. European Heart Journal, 27 (NA):300-300. [Details]
Chappell, S; Daly, L; Morgan, K; Baranes, TG; Roca, J; Rabinovich, R; Millar, A; Donnelly, SC; Keatings, V; MacNee, W; Stolk, J; Hiemstra, P; Miniati, M; Monti, S; O'Connor, CM; Kalsheker, N; ; (2006) 'Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease'. Human Mutation, 27 (1):103-109. [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Baugh, JA,Gantier, M,Li, L,Byrne, A,Buckley, A,Donnelly, SC; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 :895-903. [DOI] [Details]
Baugh JA, Gantier M, Li L, Byrne A, Buckley A, Donnelly SC. ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra P, Miniati M, Monti S, O'Connor CM, Kalsheker N.; (2006) 'Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease'. HUMAN MUTATION, 27 (1):103-109. [Details]
Naji, N. A.,Connor, M. C.,Donnelly, S. C.,McDonnell, T. J.; (2006) 'Effectiveness of pulmonary rehabilitation in restrictive lung disease'. J Cardiopulm Rehabil, 26 (4):237-43. [Details]
Plant, B.J., Gallagher, C.G., Bucala, R., Baugh, J.A., Chappell, S., Morgan, L., O'Connor, C.M., Morgan, K., Donnelly, S.C.; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, 172 (11):1412-1415. [Details]
Plant, BJ,Gallagher, CG,Bucala, R,Baugh, JA,Chappell, S,Morgan, L,O'Connor, CM,Morgan, K,Donnelly, SC; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 :1412-1415. [DOI] [Details]
Mizue, Y,Ghani, S,Leng, L,McDonald, C,Kong, P,Baugh, J,Lane, SJ,Craft, J,Nishihira, J,Donnelly, SC,Zhu, Z,Bucala, R; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 :14410-14415. [DOI] [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; ; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Mizue, Y; Ghani, S; Leng, L; McDonald, C; Kong, P; Baugh, J; Lane, SJ; Craft, J; Nishihira, J; Donnelly, SC; Zhu, Z; Bucala, R; ; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 (40):14410-14415. [Details]
Martos, R; Baugh, J; O'Loughlin, C; Ledwidge, M; Donnelly, S; McDonald, K; ; (2005) 'Diastolic heart failure is associated with elevated serum markers of collagen turnover'. European Heart Journal, 26 (NA):602-602. [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; ; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Plant, B. J.,Gallagher, C. G.,Bucala, R.,Baugh, J. A.,Chappell, S.,Morgan, L.,O'Connor, C. M.,Morgan, K.,Donnelly, S. C.; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. Am J Respir Crit Care Med, 172 (11):1412-5. [Details]
Mizue, Y., Ghani, S., Leng, L., McDonald, C., Kong, P., Baugh, J., Lane, S.J., Craft, J., Nishihira, J., Donnelly, S.C., Zhu, Z., Bucala, R.; (2005) 'Role for macrophage migration inhibitory factor in asthma'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE, 102 (40):14410-14415. [Details]
Plant, BJ; Baugh, JA; Chappell, S; Morgan, L; Keatings, V; O'Connor, C; Morgan, K; Donnelly, SC; ; (2004) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in chronic obstructive pulmonary disease'. Thorax, 59 (1):69-69. [Details]
Fisher, AJ,Donnelly, SC,Pritchard, G,Dark, JH,Corris, PA; (2004) 'Objective assessment of criteria for selection of donor lungs suitable for transplantation'. Thorax, 59 :434-437. [DOI] [Details]
Plant, BJ; Baugh, JA; Chappell, S; Morgan, L; Keatings, V; O'Connor, C; Morgan, K; Donnelly, SC; ; (2004) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in chronic obstructive pulmonary disease'. Thorax, 59 (1):69-69. [Details]
Leng, L; Metz, CN; Fang, Y; Xu, J; Donnelly, S; Baugh, J; Delohery, T; Chen, YB; Mitchell, RA; Bucala, R; ; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 (11):1467-1476. [Details]
Plant, BJ; Gallagher, CG; Baugh, JA; Plummer, S; Morgan, L; O'Connor, C; Morgan, K; Donnelly, SC; ; (2003) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in adult cystic fibrosis disease severity'. Thorax, 58 (NA):20-20. [Details]
Leng, L,Metz, CN,Fang, Y,Xu, J,Donnelly, S,Baugh, J,Delohery, T,Chen, YB,Mitchell, RA,Bucala, R; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 :1467-1476. [DOI] [Details]
Plant, BJ; Gallagher, CG; Baugh, JA; Plummer, S; Morgan, L; O'Connor, C; Morgan, K; Donnelly, SC; ; (2003) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in adult cystic fibrosis disease severity'. Thorax, 58 (NA):20-20. [Details]
Baugh JA, Donnelly SC. ; (2003) 'Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation'. Journal of Endocrinology, 179 (1):15-23. [Details]
Keane, MP,Donnelly, SC,Belperio, JA,Goodman, RB,Dy, M,Burdick, MD,Fishbein, MC,Strieter, RM; (2002) 'Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome'. J IMMUNOL, 169 :6515-6521. [Details]
Keane, MP, Donnelly, SC, Belperio, JA, Goodman, RB, Dy, M, Burdick, MD, Fishbein, MC, Strieter, RM, ; (2002) 'Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome'. J IMMUNOL, 169 (11):6515-6521. [Details]
O'Reilly, KMA; Baugh, JA; Plant, BJ; Fitzgerald, MX; Bucala, R; Donnelly, SC; ; (2002) 'Macrophage Migration Inhibitory Factor induces proliferation and has pro-fibrotic effects in primary human pulmonary fibroblasts'. Thorax, 57 (NA). [Details]
Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, Bucala R. ; (2002) 'A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis'. Genes and Immunity, 3 (3):170-176. [Details]
CROWLEY, JJ,DONNELLY, SM,TOBIN, M,FITZGERALD, O,BRESNIHAN, B,MAURER, BJ,QUIGLEY, PJ; (1993) 'DOPPLER-ECHOCARDIOGRAPHIC EVIDENCE OF LEFT-VENTRICULAR DIASTOLIC DYSFUNCTION IN ANKYLOSING-SPONDYLITIS'. American Journal of Cardiology, 71 :1337-1340. [Details]
Plant, BJ; Ghani, S; O'Mahony, MJ; Morgan, L; O'Connor, CM; Morgan, K; Baugh, JA; Donnelly, SC; ; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. European Respiratory Journal, 29 (2):325-329. [Details]
Martos, R; Baugh, J; Ledwidge, M; O'Loughlin, C; Conlon, C; Patle, A; Donnelly, SC; McDonald, K; ; (2007) 'Diastolic heart failure - Evidence of increased myocardial collagen turnover linked to diastolic dysfunction'. Circulation, 115 (7):888-895. [Details]
Chappell, S; Daly, L; Morgan, K; Baranes, TG; Roca, J; Rabinovich, R; Millar, A; Donnelly, SC; Keatings, V; MacNee, W; Stolk, J; Hiemstra, P; Miniati, M; Monti, S; O'Connor, CM; Kalsheker, N; ; (2006) 'Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease'. Human Mutation, 27 (1):103-109. [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Martos, R; Patle, A; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population'. European Heart Journal, 27 (NA):300-300. [Details]
Martos, R; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure'. European Heart Journal, 27 (NA):844-844. [Details]
Plant, B.J., Ghani, S., O'mahony, M.J., Morgan, L., O'connor, C.M., Morgan, K., Baugh, J.A. Donnelly, S.C.; (2006) 'Sarcoidosis and a MIF gene polymorphism: a case-control study in an Irish Population'. EUROPEAN RESPIRATORY JOURNAL, . [Details]
Baugh, JA; Gantier, M; Li, L; Byrne, A; Buckley, A; Donnelly, SC; ; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 (4):895-903. [Details]
Chappell, S; Daly, L; Morgan, K; Baranes, TG; Roca, J; Rabinovich, R; Millar, A; Donnelly, SC; Keatings, V; MacNee, W; Stolk, J; Hiemstra, PS; Miniati, M; Monti, S; O'Connor, CM; Kalsheker, N; ; (2006) 'The SERPINE2 gene and chronic obstructive pulmonary disease'. American Journal of Human Genetics, 79 (1):184-186. [Details]
Martos, R; Baugh, J; O'Loughlin, C; Ledwidge, M; Donnelly, S; McDonald, K; ; (2005) 'Diastolic heart failure is associated with elevated serum markers of collagen turnover'. European Heart Journal, 26 (NA):602-602. [Details]
Mizue, Y; Ghani, S; Leng, L; McDonald, C; Kong, P; Baugh, J; Lane, SJ; Craft, J; Nishihira, J; Donnelly, SC; Zhu, Z; Bucala, R; ; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 (40):14410-14415. [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; ; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Fisher, AJ; Donnelly, SC; Pritchard, G; Dark, JH; Corris, PA; ; (2004) 'Objective assessment of criteria for selection of donor lungs suitable for transplantation'. Thorax, 59 (5):434-437. [Details]
Plant, BJ; Baugh, JA; Chappell, S; Morgan, L; Keatings, V; O'Connor, C; Morgan, K; Donnelly, SC; ; (2004) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in chronic obstructive pulmonary disease'. Thorax, 59 (1):69-69. [Details]
Mulcahy, G; O'Neill, S; Donnelly, S; Dalton, JP; ; (2004) 'Helminths at mucosal barriers - interaction with the immune system'. ADVANCED DRUG DELIVERY REVIEWS, 56 (6):853-868. [Details]
Plant, BJ; Gallagher, CG; Baugh, JA; Plummer, S; Morgan, L; O'Connor, C; Morgan, K; Donnelly, SC; ; (2003) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in adult cystic fibrosis disease severity'. Thorax, 58 (NA):20-20. [Details]
Leng, L; Metz, CN; Fang, Y; Xu, J; Donnelly, S; Baugh, J; Delohery, T; Chen, YB; Mitchell, RA; Bucala, R; ; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 (11):1467-1476. [Details]
Baugh, JA; Donnelly, SC; ; (2003) 'Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation'. Journal of Endocrinology, 179 (1):15-23. [Details]
Dalton, JP; Brindley, PJ; Knox, DP; Brady, CP; Hotez, PJ; Donnelly, S; O'Neill, SM; Mulcahy, G; Loukas, A; ; (2003) 'Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression'. International Journal for Parasitology, 33 (5-6):621-640. [Details]
O'Reilly, KMA; Baugh, JA; Plant, BJ; Fitzgerald, MX; Bucala, R; Donnelly, SC; ; (2002) 'Macrophage Migration Inhibitory Factor induces proliferation and has pro-fibrotic effects in primary human pulmonary fibroblasts'. Thorax, 57 (NA). [Details]
Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, Bucala R. ; (2002) 'A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis'. Genes and Immunity, 3 :170-176. [Details]
Fisher, A. J., Donnelly, S. C., Hirani, N., Haslett, C., Strieter, R. M., Dark, J. H., and Corris, P. A.; (2001) 'Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation'. American Journal of Respiratory and Critical Care Medic, 163 (1):259-265. [Details]
Abe R., Donnelly, S. C., Peng, T., Bucala, R., and Metz, C. N.; (2001) 'Peripheral blood fibrocytes: differentiation pathway and migration to wound sites'. Immunology, 166 (12):7556-7562. [Details]
Hirani, N., Antonicelli, F., Strieter, R. M., Wiesener, M. S., Ratcliffe, P. J., Haslett, C., Donnelly, S. C.; (2001) 'The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)'. Molecular Medicine, 7 (10):685-697. [Details]
Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, Chilvers ER, Dransfield I, Donnelly SC, Strieter R, Haslett C. ; (1999) 'Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo'. Nat Medicine, 5 :662-668. [Details]
Fisher AJ, Donnelly SC, Hirani N, Burdick MD, Strieter RM, Dark JH, Corris PA. ; (1999) 'Enhanced pulmonary inflammation in organ donors following fatal non-traumatic brain injury'. Lancet, 353 :1412-1413. [Details]
Rossi, A. G., Haslett, C., Hirani, N., Greening, A. P., Rahman, I., Metz, C. N., Bucala, R., and Donnelly, S. C.; (1998) 'Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma'. Clinical Investigation, 101 (12):2869-2874. [Details]
Rossi AG, Haslett C, Metz CN, Rahman I, Bucala R, Donnelly SC. ; (1998) 'Eosinophils are a source of macrophage migration inhibitory factor (MIF) ' potential role in asthma'. Journal of Clinical Investigation, 101 :2869-2874. [Details]
Donnelly, S. C., Haslett, C., Reid, P. T., Grant, I. S., Wallace, W. A., Metz, C. N., Bruce, L. J., and Bucala R.; (1997) 'Regulatory role for macrophage migration inhibitory factor in acute respiratory distresssyndrome'. Nat Medicine, 3 (3):320-323. [Details]
Donnelly, S. C., Strieter, R. M., Reid, P. T., Kunkel, S. L., Burdick, M. D., Armstrong, I., Mackenzie, A., and Haslett, C.; (1996) 'The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome'. Annals of International Medicine, 125 (3):191-196. [Details]
Donnelly SC, Strieter RM, Reid PT, Kunkel SL, Burdick MD, Armstrong I, McKenzie, A, Haslett C. ; (1996) 'Prognostic significance of Interleukin-10 (IL-10) and IL-1 receptor antagonist (IL-Ira), in broncho-alveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS)'. Annals of Internal Medicine, 125 :191-196. [Details]
Donnelly, S. C., Haslett, C., Dransfield, I., Robertson, C. E., Carter, D. C., Ross, J. A. , Grant, I. S. , Tedder, T. F.; (1994) 'Role of selectins in development of adult respiratory distress syndrome'. Lancet, 344 (8917):215-219. [Details]
Donnelly, S. C., Strieter, R. M., Kunkel, S. L., Walz, A., Robertson, C. R., Carter, D. C., Grant, I. S., Pollok, A. J., and Haslett, C.; (1993) 'Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups'. Lancet, 341 (8846):643-647. [Details]

Other Journals

Naji, N.A., Connor, C.M., Donnelly, S.C. McDonnell, T.J.; (2006) 'Effectiveness of pulmonary rehabilitation in restrictive lung disease' j Cardiopulm Rehabil . [Details]
Naji, N.A., Connor, C.M., Donnelly, S.C. McDonnell, T.J.; (2006) 'Effectiveness of pulmonary rehabilitation in restrictive lung disease' j Cardiopulm Rehabil . [Details]

Conference Publications

Adamali HI, Baugh J, Fingerle-Rowson G, McLoughlin P, Donnelly SC; (2008) Enzymatic actvity of macrophage inhibitory factor (MIF) regulates growth of pseudomonas aeruginosa (Pa): implications for therapeutic interventions in cystic fibrosis American Thoracic Society International Conference [Details]
Phelan, D, Watson, CJ, Donnelly, S, Ledwidge, M, Baugh, J, Mcdonald, K, ; (2007) EUR J HEART FAIL Transforming growth factor beta induces collagen type I and alpha smooth muscle actin production in human cardiac fibroblasts , pp.101-101 [Details]
Watson, CJ, Phelan, DMJ, Ledwidge, M, Donnelly, S, Mcdonald, K, Baugh, J, ; (2007) EUR J HEART FAIL Increased MMP2 activity following treatment of cardiac fibroblast with Angiotensin II, Alclosterone, Endothelin-1 and TGF beta , pp.101-101 [Details]
Byrne, A., Li, L., Gantier, M., Donnelly, S.C. Baugh, J.A.; (2006) Hypoxia-Induced Fibroroliferation is Rho Dependent and Augmented by Macrophage Migration Inhibitory Factor (MIF) American Thoracic Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Conlon, C., Donnelly, S. McDonald, K.; (2006) Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure Heart Failure Congress [Details]
Kettunen, M., Brennan, L., Govender, P., Newsholme, P., Baugh, J.A. Donnelly S.C.; (2006) 1H NMR Analysis of BAL Fluid as a Potential Prognostic Tool in Sarcoidosis American Thoracic Society [Details]
Li, L., O'Reilly, KMA., Buckley, A., Byrne, A.B., McLaughlin, A.M., Kettunen, M.P, Govender, P., Baugh, J.A., Donnelly, S.C.; (2006) Sarcoidosis Bronchoalveolar Lavage (BAL) Fluid Induces the Differentiation of Normal Human Primary Lung Fibroblasts into Myofibroblasts American Thoracic Society [Details]
Li, L., Byrne, A., O'Reilly, K.M.A., Donnelly S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factory (MFI) is an early growth response-1 (EGR-1) target gene in TGFb activated human lung fibroblasts American Thoracic Society [Details]
Byrne, A., Li, L., Gantier, M., Buckley, A., O'Reilly, K., Donnelly, S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factor (MIF): A Hypoxia Regulated Mediator of Pulmonary Fibrosis Hypoxia and Development, Physiology and Disease (Keystone) [Details]
Byrne, A., Li, L., Gantier, M., Donnelly, S.C. Baugh, J.A.; (2006) Hypoxia-Induced Fibroroliferation is Rho Dependent and Augmented by Macrophage Migration Inhibitory Factor (MIF) American Thoracic Society [Details]
Kettunen, M., Brennan, L., Govender, P., Newsholme, P., Baugh, J.A. Donnelly S.C.; (2006) 1H NMR Analysis of BAL Fluid as a Potential Prognostic Tool in Sarcoidosis American Thoracic Society University of New Mexico, Albuquerque, [Details]
Li, L., O'Reilly, KMA., Buckley, A., Byrne, A.B., McLaughlin, A.M., Kettunen, M.P, Govender, P., Baugh, J.A., Donnelly, S.C.; (2006) Sarcoidosis Bronchoalveolar Lavage (BAL) Fluid Induces the Differentiation of Normal Human Primary Lung Fibroblasts into Myofibroblasts American Thoracic Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Irish Cardiac Society [Details]
Martos, R., Baugh, J., Ledwidge, M., Patle, A., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Brain natriuretic peptide levels correlate with indices of diastolic function and serum markers of increased collagen turnover Irish Cardiac Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Heart Failure Congress [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover World Congress of Cardiology [Details]
Li, L., Byrne, A., O'Reilly, K.M.A., Donnelly S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factory (MFI) is an early growth response-1 (EGR-1) target gene in TGFb activated human lung fibroblasts American Thoracic Society [Details]
Byrne, A., Li, L., Gantier, M., Buckley, A., O'Reilly, K., Donnelly, S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factor (MIF): A Hypoxia Regulated Mediator of Pulmonary Fibrosis Hypoxia and Development, Physiology and Disease (Keystone) [Details]
                       

Abstract

Keane MP, Donnelly SC, Belperio JA, Goodman R, Burdick MD, Strieter RM; (2002) IL-8 correlates with BALF angiogenic activity and pro-collagen levels in ARDS. Abstract [Details]
                                                               

Research

Research Interests

Our research work epitomises Translational Medicine where original bench based observations are translated to clinical disease. In particular we define key regulatory mechanisms which drive aberrant remodelling and repair and predispose towards chronic inflammatory diseases.

We are particularly interested in:

  • Development of novel anti-inflammatory small molecular weight therapies
  • Host environmental influences on the regulation of the inflammatory response.
  • Genetic profiling guiding disease diagnosis, prognosis and response to therapy
  • Host/Pathogen interactions which predispose towards more aggressive infection.


We utilise advanced cell and molecular biology techniques, in vitro cell and in vivo animal models to address these questions. It is our vision that our work will pave the way for specific tailored therapies which would attenuate key regulatory pathways which drive chronic inflammatory disease.




FUNDING AGENCIES:
Heath Research Board
Science Foundation Ireland (SFI)
The Wellcome Trust
European Community

Research Projects

Sponsor : The Irish Platform for Patients' Organisations, Science and Industry (IPPOSI)
Title : National Strategic Forum on Clinical Research
Start Date / End Date : 01-DEC-09 / 30-NOV-10
Sponsor : West Offaly Enterprise Fund Ltd
Title : Sarcoidosis research
Start Date / End Date : 01-JAN-10 / 31-DEC-13
Sponsor : Science Foundation Ireland (SFI)
Title : National strategic forum for clinical research
Start Date / End Date : 01-OCT-09 / 31-DEC-09
Sponsor : Science Foundation Ireland (SFI)
Title : Macrophage Migration Inhibitory Factor (MIF), enzymatic activity and pulmonary disease
Start Date / End Date : 01-SEP-09 / 01-SEP-14
Sponsor : University College Dublin (UCD)
Title : In vivo models of hypoxic lung disease
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Irish Sarcoidosis Support Network (ISSN)
Title : To define prevalence of Sarcoidosis
Start Date / End Date : 01-MAR-08 / 01-MAR-09
Sponsor : Glaxo Smith Kline, UK
Title : Clinical Research in Pulmonary Medicine
Start Date / End Date : 01-AUG-07 / 31-DEC-13
Sponsor : Altana Pharma AG
Title : The CATT Repeat Polymorphism in Human MIF Promotor Confers Genetic Susceptibility to enhanced innate responses via Upregulation of TLR4 Expression
Start Date / End Date : 01-JUL-04 / 30-JUN-05
Sponsor : University College Dublin (UCD)
Title : Macrophage Migration Inhibitory Factor (MIF) and Sarcoidosis
Start Date / End Date : 01-MAY-01 / 30-APR-04
Sponsor : Cystic Fibrosis Association of Ireland (CFAI)
Title : Macrophage migration inhibitory factor (MIF) and Cystic Fibrosis (CF) disease pathogenesis
Start Date / End Date : 01-SEP-04 / 30-AUG-07
Sponsor : Health Research Board (HRB)
Title : The CATT-repeat polymorphism in human MIF promoter confers genetic susceptibility to enhanced innate responses via upregulation of TLR4 expression
Start Date / End Date : 01-JUL-04 / 30-JUN-06
Sponsor : University of Glasgow
Title : Prognostic & predictive markers in colorectal cancer
Start Date / End Date : 01-MAY-03 / 30-APR-04
Sponsor : Science Foundation Ireland (SFI)
Title : Macrophage migration inhibitory factor (MIF), aberrant remodelling/repair & chronic inflammation
Start Date / End Date : 01-NOV-02 / 31-OCT-06
Sponsor : Wellcome Trust, UK
Title : Macrophage migration inhibitory factor (MIF) & inflammatory lung disease
Start Date / End Date : 01-NOV-01 / 30-APR-03
Sponsor : Irish Lung Foundation
Title : Funds provided for Laboratory/Office Equipment
Start Date / End Date : 01-JAN-01 / 30-JUN-02
   

Collaborators

Internal Collaborators

Team

Dr. Michelle Armstrong, Senior PostDoctoral Scientist

Dr Helen Conroy, Senior PostDoctoral Scientist

Dr. Gordon Cooke, PostDoctoral Scientist

Ms Marie Claire Kennedy, Research Assistant

Ms Mary Walters, Clinical Research Nurse

Ms Leona Mawhinney, PhD Student

Dr David O'Dwyer, PhD Student

Dr Huzaifa Adamali, MD Student

External Collaborators

Professor Tariq Sethi, UCL, London

Professor Chris Haslett, University of Edinburgh

Professor Moira Whyte, Sheffield University

Dr Nik Hirani, University of Edinburgh

Professor Rick Bucala, Yale University

Professor Cory Hogaboam, University of Michigan

Professor Steve Kunkel,  University of Michigan

Professor David Moller, Johns Hopkins Medical School.

Professor David Lloyd, Trinity College Dublin