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Researchers at UCD

researcher

Pauline Walsh

Postdoc Research Fellow Lvl Ii

School Of Medicine & Medical Science
Mater Hospital
Eccles Street
Dublin 7

Tel: +353 1 7166383
Email: paulinem.walsh@ucd.ie

Publications

     

Peer Reviewed Journals

Baker JF, Walsh PM, Byrne DP, Mulhall KJ (2012) 'Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1 beta'. Journal Of Orthopaedic Trauma, 13 (3):119-123. [DOI] [Details]
Baker JF, Walsh PM, Byrne DP, Mulhall KJ; (2011) 'In vitro assessment of human chondrocyte viability after treatment with local anaesthetic, magnesium sulphate or normal saline'. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 19 (6):1043-1046. [DOI] [Details]
Hepburn J, Walsh P, Mulhall KJ; (2011) 'The chondrotoxicity of local anaesthetics: Any clinical impact?'. Spine, 78 (5):438-440. [DOI] [Details]
Murphy T, Walsh PM, Doran PP, Mulhall KJ; (2010) 'Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients'. Journal of translational medicine, 8 . [DOI] [Details]
Baker JF, Byrne DP, Walsh PM, Mulhall KJ; (2010) 'Human Chondrocyte Viability After Treatment With Local Anesthetic and/or Magnesium: Results From an In Vitro Study'. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, . [DOI] [Details]
Baker JF, Walsh P, Mulhall KJ; (2010) 'Statins: A potential role in the management of osteoarthritis?'. Spine, . [DOI] [Details]
                                                                                             

Research

Research Interests

                      

My research focuses on the investigation of ischaemic preconditioning as a potential therapeutic strategy for the improving patient outcome in orthopaedic surgical patients. Ischaemic preconditioning refers to the phenomenon whereby exposure of a tissue to a brief period of sub-lethal ischaemia results in protection against a subsequent prolonged period of ischaemia.  It has been shown to protect against ischaemia-reperfusion injury in a number of clinical settings, and has been widely studied in cardiac surgery with increasing investigation in the areas of vascular surgery, acute kidney injury, stroke and transplant surgery.  This technique may also have potential in orthopaedic surgery, for example in extremity surgery involving the use of a tourniquet.  Therapeutic benefits for orthopaedic patients may include reduced post-operative pain, reduced systemic inflammation and oxidative stress, and improved functional outcome following surgery.  

I am currently involved in a prospective randomised controlled study of ischaemic preconditioning in total knee replacement patients. This study aims to investigate if ischaemic preconditioning can improve clinical outcome in this cohort of patients. My work also focuses on the role of reactive oxygen species and oxidative stress in the molecular mechanism of ischaemic preconditioning; this work is conducted using tissue samples taken from control and preconditioned knee replacement patients, and is complemented by in vitro models of ischaemic preconditioning using skeletal muscle myotubes.

Other research interests include the investigation of statins as a potential therapy for osteoarthritis, and the effect of agents such as local anaesthetics and contrast media on cartilage integrity.