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Bill Watson

Conway Fellow

School of Medicine & Medical Science

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Biography

Professor Watson received his PhD degree in Biochemistry from the Department of Biochemistry, University College Cork in 1995. He then undertook his post-doctoral research in University of Toronto and the Toronto General Hospital in Canada, before returning in 1997, to the Department of Surgery, Mater Misericordiae University Hospital, University College Dublin and is now Associate Professor of Cancer Biology in the UCD School of Medicine and Medical Science. Apart from his undergraduate and post-graduate teaching responsibilities, he has an active internationally recognised research group. As a translational biologist based in the Conway Institute he utilises latest technologies to study cellular and molecular pathways and clinical collaboration through the Prostate Cancer Research Consortium (of which he is the lead PI) to expand the understanding of the initiation and progression of prostate cancer in order to identify diagnostic and prognostic biomarkers and therapeutic sites for manipulation. Professor Watson is Section editor of the Scientific Discovery section of the BJUInternational, Chair of the Basic Research Section of the European Association for Urology Research Foundation, Principal Investigator in Molecular Medicine Ireland.

Professional

Honours and Awards

Year: 1990.
Title: Mayo Clinic, Undergraduate Research Fellowship
Year: 1993.
Title: Shepherd Trust prize. Royal College of Surgeons in Ireland
Year: 1995.
Title: Council prize
Year: 1995.
Title: Young Investigator Award
Year: 1995.
Title: Student Travel Award
Year: 1995.
Title: Young Investigator Award
Year: 1996.
Title: Post Doctoral Travel Award
Year: 1996.
Title: William O'Keeffe Memorial Prize
Year: 1997.
Title: Post Doctoral Travel Award
Year: 1998.
Title: Presidents Award
Year: 2000.
Title: Presidents Award
Year: 2000.
Title: Alton Prize

Associations

Association: Irish Association for Cancer Research, Function/Role: Secretary
Association: Cancer Research Ireland, Function/Role: Board Member
Association: Action Cancer, UK, Function/Role: Scientific committee member
       

Committees

Committee : European Association of Urology Research Foundation - Basic Science
Committee : Biomedical Health and Life Science BSc Degree
Committee : Irish Association for Cancer Research
Committee : DMMC Gene Bank Management Group
Committee : Human Research Ethics Committee - Life Sciences
Committee : SMMS Research Degrees Committee

Employment

Employer: Royal College of Surgeons in Ireland
Position: Ph.D. Student
Employer: University of Toronto and Toronto General Hospital
Position: Post Doctoral Research Fellow
Employer: University College Dublin
Position: College Lecturer

Education

Year 1991 Institution: University College Dublin
Qualification: BSc Subject:
Year 1995 Institution: Royal Coll Surgeons in Ireland
Qualification: PhD Subject:
Year 1992 Institution: Dublin Institute of Technology (DIT), IRL
Qualification: GRSC Subject:
       

Other Activities

Chair, Organising Committee of the 7th World Basic Urological Research Congress January 2005 - present. This is the Joint meeting of the European Society for Urological Research and the Society for Basic Urologic Research in the US which will be hosted in UCD on the 27-29th September 2007.

Publications

 

Book Chapters

Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson, W., Cunningham, P. and Gallagher, W. ; (2008) 'Automated Image Analysis Approaches in Histopathology' In: Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson, W., Cunningham, P. and Gallagher, W. ; (eds). Handbook of Research on Systems Biology Applications in Medicine. Hershey, Pennsylvania: IGI Global. [Details]
Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson R. W., Cunningham, P., Gallagher, W. M.; (2008) 'Automated image analysis approaches in histopathology' In: Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson R. W., Cunningham, P., Gallagher, W. M.; (eds). Handbook of Research on Systems Biology Applications in Medicine. Berlin, Germany: Andriani Daskalaki, Max Planck Institute for Molecular Genetics. , pp.826-849 [Details]
Walsh, S.E., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Apoptosis and prostate cancer' In: Walsh, S.E., Fitzpatrick, J.M. Watson, R.W.G.; (eds). Prostate Cancer Principles and Practice. London: Taylor & Francis. [Details]
Watson R.W.G., McLornan L., McEleny K., Fitzpatrick J.M.; (2003) 'Update on the regulation of apoptosis in prostate Cancer' In: J. Mydlo (eds). Prostate Cancer. , pp.45-53 [Details]
Morrissey C., Watson R.W.G, Fitzpatrick J.M.; (2003) 'Apoptosis in the Prostate' In: Kirby R. and OLeary M (eds). Hot Topics in Urology. [Details]
Watson R.W.G., Coffey R., Fitzpatrick J.M.; (2000) 'Future Trends in Basic Research: Apoptosis as a target' In: A. Belldegrun, R. Kirby and D.W.W. Newling (eds). New Perspectives in Prostate Cancer. , pp.115-125 [Details]
Watson R.W.G.; (1998) 'Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines' In: H. Redl and G. Schlaged (eds). Cytokines in severe sepsis and septic shock. , pp.213-226 [Details]
MarshallJ. C., Watson R.W.G.; (1997) 'Apoptosis in the resolution of systemic inflammation' In: * (eds). Yearbook in Intensive Care and Emergency Medicine. , pp.100-108 [Details]
 

Peer Reviewed Journals

Lundon DJ, Kelly BD, Foley R, Loeb S, Fitzpatrick JM, Watson RW, Rogers E, Durkan GC, Walsh K (2014) 'Prostate cancer risk assessment tools in an unscreened population'. World Journal of Urology, . [DOI] [Details]
O'Hurley G, Prencipe M, Lundon D, O'Neill A, Boyce S, O'Grady A, Gallagher WM, Morrissey C, Kay EW, Watson RW (2014) 'The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases'. Prostate, 74 (3):306-313. [DOI] [Details]
Boyce, S., Fan, Y., Watson, R.W. and Murphy, T.B. (2013) 'Evaluation of prediction models for the staging of prostate cancer'. BMC Medical Informatics and Decision Making, 13 . [DOI] [Details]
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753. [DOI] [Details]
Corcoran, C,Rani, S,O'Brien, K,O'Neill, A,Prencipe, M,Sheikh, R,Webb, G,McDermott, R,Watson, W,Crown, J,O'Driscoll, L (2012) 'Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes'. PLoS ONE, 7 . [DOI] [Details]
Oon, SF,Fanning, DM,Fan, Y,Boyce, S,Murphy, TB,Fitzpatrick, JM,Watson, RW (2012) 'The identification and internal validation of a preoperative serum biomarker panel to determine extracapsular extension in patients with prostate cancer'. Prostate, 72 :1523-1531. [DOI] [Details]
Murphy, L,Watson, RW (2012) 'Patented prostate cancer biomarkers'. Nature reviews. Urology, 9 :464-472. [DOI] [Details]
Bellmunt, J,Attard, G,Bahl, A,Huland, H,Klotz, L,Kuban, D,Oudard, S,Watson, W (2012) 'Advances in the management of high-risk localised and metastatic prostate cancer'. BJU international, 109 :8-13. [DOI] [Details]
O'Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O'Connor D, O'Connor R, Devery A, Corcoran C, Rani S, O'Driscoll L, Fitzpatrick JM, Watson RW (2011) 'Characterisation and manipulation of docetaxel resistant prostate cancer cell lines'. MOL CANCER, 10 (126). [Details]
Oon SF, Pennington SR, Fitzpatrick JM, Watson RW (2011) 'Biomarker research in prostate cancer--towards utility, not futility'. Nature reviews. Urology, 8 (3):131-138. [DOI] [Details]
Oon, S.F., Fanning, D.M., Fan, Y., Boyce, S., Murphy, T.B., Fitzpatrick, J.M. and Watson, R.W.G.; (2012) 'The identification and validation of a preoperative serum biomarker panel to determine extracapsular extension in patients with prostate cancer'. Prostate, 72 (14):1523-1531. [DOI] [Details]
O'Connell K, Prencipe M, O'Neill A, Corcoran C, Rani S, Henry M, Dowling P, Meleady P, O'Driscoll L, Watson W, O'Connor R (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 (13):2115-2126. [DOI] [Details]
Kennedy SA, Scaife C, Dunn MJ, Wood AE, Watson RW.; (2011) 'Benefits of heat treatment to the protease packed neutrophil for proteome analysis: halting protein degradation'. Proteomics, 11 (12):2560-2564. [Details]
Oon SF, Pennington SR, Fitzpatrick JM, Watson RW; (2011) 'Biomarker research in prostate cancer-towards utility, not futility'. Nature reviews. Cancer, 8 (3):131-138. [Details]
DiFranco, M.D., O'Hurley, G., Kay, E.W., Watson, R.W.G., Cunningham, P.,; (2011) 'Ensemble based methodology for whole-slide prostate cancer probability mapping'. Computerized Medical Imaging and Graphics, . Available Online [DOI] [Details]
Oon SF, Watson RW, O'Leary JJ, Fitzpatrick JM.; (2011) 'Epstein criteria for insignificant prostate cancer'. BJU international, 108 (4):518-525. [Details]
Fan, Y., Murphy, T.B., Byrne, J., Brennan, L., Fitzpatrick, J. and Watson, R.W.G.; (2011) 'Applying Random Forests to identify biomarker panels in serum 2D-DIGE data for the detection and staging of prostate cancer'. Journal of Proteome Research, 10 (3):1361-1373. [DOI] [Details]
O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A., Corcoran C., Rani S., O¿Driscoll L., Fitzpatrick J., R., Watson R.W.G. ; (2011) 'Characterisation and Manipulation of Docetaxel Resistant Prostate Cancer Cell Lines'. MOL CANCER, . [Details]
Fan, Y,Murphy, TB,Byrne, JC,Brennan, L,Fitzpatrick, JM,Watson, RWG; (2011) 'Applying Random Forests To Identify Biomarker Panels in Serum 2D-DIGE Data for the Detection and Staging of Prostate Cancer'. Journal of Proteome Research, 10 :1361-1373. [DOI] [Details]
Saldova, R,Fan, Y,Fitzpatrick, JM,Watson, RWG,Rudd, PM; (2011) 'Core fucosylation and alpha 2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia'. Glycobiology, 21 :195-205. [DOI] [Details]
Watson RW, Kinsella A, Raza A, Kennedy S, Fan Y, Wood AE (2011) 'The impact of high-dose statin therapy on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers'. Journal of clinical pharmacology, 67 (11):1103-1108. [DOI] [Details]
Cuffe, S,Dowling, CM,Claffey, J,Pampillon, C,Hogan, M,Fitzpatrick, JM,Carty, MP,Tacke, M,Watson, RWG; (2011) 'Effects of Titanocene Dichloride Derivatives on Prostate Cancer Cells, Specifically DNA Damage-Induced Apoptosis'. Prostate, 71 :111-124. [DOI] [Details]
DiFranco, MD,O'Hurley, G,Kay, EW,Watson, RWG,Cunningham, P; (2011) 'Ensemble based system for whole-slide prostate cancer probability mapping using color texture features'. Computerized Medical Imaging and Graphics, 35 :629-645. [DOI] [Details]
Kennedy, SA,Scaife, C,Dunn, MJ,Wood, AE,Watson, RWG; (2011) 'Benefits of heat treatment to the protease packed neutrophil for proteome analysis: Halting protein degradation'. Proteomics, 11 :2560-2564. [DOI] [Details]
Fanning, DM,Kay, E,Fan, Y,Fitzpatrick, JM,Watson, RWG; (2010) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4+3 as high or intermediate grade'. BJU international, 105 :631-635. [DOI] [Details]
Fanning, DM,Fan, Y,Fitzpatrick, JM,Watson, RWG; (2010) 'External Validation of the 2007 and 2001 Partin Tables in Irish Prostate Cancer Patients'. Urologia Internationalis, 84 :174-179. [DOI] [Details]
Fanning, DM,Yue, F,Fitzpatrick, JM,Watson, RWG; (2010) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. IRISH J MED SCI, 179 :187-195. [DOI] [Details]
Watson RW, Kay EW, Smith D; (2010) 'Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research'. nature review cancer, 10 (9):646-651. [Details]
Quinlan MR, Cronin P, Daly PJ, Watson RW, Manucha W, Docherty NG, Fitzpatrick JM.; (2010) 'A gender comparison of postobstructive injury in the rat kidney'. KIDNEY BLOOD PRESS R, 33 (4):266-73. [Details]
Fizazi K, Sternberg CN, Fitzpatrick JM, Watson RW, Tabesh M; (2010) 'Role of targeted therapy in the treatment of advanced prostate cancer'. BJU international, 105 (6):748-767. [DOI] [Details]
Burke JP, Watson RW, Mulsow JJ, Docherty NG, Coffey JC, O'Connell PR; (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. The British journal of surgery, 97 (6):892-901. [DOI] [Details]
Burke JP, Cunningham MF, Watson RW, Docherty NG, Coffey JC, O'Connell PR; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. The British journal of surgery, 97 (7):1126-1134. [DOI] [Details]
Fanning, D. M.,Yue, F.,Fitzpatrick, J. M.,Watson, R. W.; (2010) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Irish Journal of Medical Science, 179 (22):187-95187. Available Online [Details]
Smyth, L. G.,O'Hurley, G.,O'Grady, A.,Fitzpatrick, J. M.,Kay, E.,Watson, R. W.; (2010) 'Carbonic anhydrase IX expression in prostate cancer'. Prostate Cancer and Prostatic Diseases, 13 (22):178-81178. Available Online [Details]
Cuffe S, Dowling CM, Claffey J, Pampillón C, Hogan M, Fitzpatrick JM, Carty MP, Tacke M, Watson RW; (2010) 'Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis'. Prostate, . [Details]
Watson RW, Maher BM, Dhonnchu TN, Burke JP, Soo A, Wood AE, ; (2009) 'Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?'. Journal of Leukocyte Biology, 85 (1):186-193. [DOI] [Details]
Watson RW, Gill C, Dowling C, O'Neill AJ, ; (2009) 'Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation'. Cancer, 8 . [DOI] [Details]
Watson RW, Soo A, Maher B, McCarthy J, Nölke L, Wood A, ; (2009) 'Pre-operative Determination of an Individual's Neutrophil Response: A Potential Predictor of Early Cardiac Transplant Cellular Rejection'. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, . [DOI] [Details]
Watson RW, Docherty NG, Calvo IF, Quinlan MR, Pérez-Barriocanal F, McGuire BB, Fitzpatrick JM, ; (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney International, 2 (NA):205-213. [DOI] [Details]
McCann A, Watson JA, Watson CJ, McCrohan AM, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson RW, ; (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Human Molecular Genetics, 18 (19):3594-3604. [DOI] [Details]
Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, ; (2009) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade'. BJU international, . [DOI] [Details]
Watson RW, Walsh S, Gill C, O'Neill A, Fitzpatrick JM, ; (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. International Journal of Cancer, 124 (8):1871-1878. [DOI] [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
St John Floyd, M., Jr.,Teahan, S. J.,Fitzpatrick, J. M.,Watson, R. W.; (2009) 'Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines'. Prostate Cancer Prostatic Dis, 12 (11):25-3325. Available Online [Details]
Fan, Y.,Murphy, T. B.,Watson, R. W.; (2009) 'digeR: a graphical user interface R package for analyzing 2D-DIGE data'. Bioinformatics, 25 (2222):3033-43033. Available Online [Details]
Watson, J. A.,Watson, C. J.,McCrohan, A. M.,Woodfine, K.,Tosetto, M.,McDaid, J.,Gallagher, E.,Betts, D.,Baugh, J.,O'Sullivan, J.,Murrell, A.,Watson, R. W.,McCann, A.; (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Hum Mol Genet, 18 (1919):3594-6043594. Available Online [Details]
Walsh, S,Gill, C,O'Neill, A,Fitzpatrick, JM,Watson, RWG; (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. Cancer, 124 :1871-1878. [DOI] [Details]
Soo, A,Maher, B,McCarthy, J,Nolke, L,Wood, A,Watson, RWG; (2009) 'Pre-operative Determination of an Individual's Neutrophil Response: A Potential Predictor of Early Cardiac Transplant Cellular Rejection'. Heart, 28 :1198-1205. [DOI] [Details]
Floyd, MSJ,Teahan, SJ,Fitzpatrick, JM,Watson, RWG; (2009) 'Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines'. Prostate, 12 :25-33. [DOI] [Details]
Byrne, JC,Downes, MR,O'Donoghue, N,O'Keane, C,O'Neill, A,Fan, Y,Fitzpatrick, JM,Dunn, MJ,Watson, RWG; (2009) '2D-DIGE as a Strategy To Identify Serum Markers for the Progression of Prostate Cancer'. Journal of Proteome Research, 8 :942-957. [DOI] [Details]
Foley, R,Marignol, L,Thomas, AZ,Cullen, IM,Perry, AS,Tewari, P,O'Grady, A,Kay, E,Dunne, B,Loftus, B,Watson, RW,Fitzpatrick, JM,Woodson, K,Lehman, T,Hollywood, D,Lynch, TH,Lawler, M; (2009) 'The HIF-1 alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers'. Cancer, 8 :118-124. [Details]
Daly, PJ,Docherty, NG,Healy, DA,McGuire, BB,Fitzpatrick, JM,Watson, RWG; (2009) 'The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage'. BJU international, 103 (NA):254-259. [DOI] [Details]
Watson RW, Fanning DM, Yue F, Fitzpatrick JM, ; (2009) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Irish Journal of Medical Science, (NA). [DOI] [Details]
Molloy, E. J., O'Neill, A. J., Grantham-Sloan, J. J., Webb, D. W., Watson, R. W. G., ; (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Clinical and Experimental Immunology, 151 (2):244-250. [Details]
Byrne, J. C., Downes, M. R., O'Donoghue, N., Fitzpatrick, J. M., Dunn, M. J., Watson, R. W. G., ; (2008) 'Fasting status as a consideration for human serum collection and preparation prior to depletion and analysis'. Electrophoresis, 29 (14):3055-3059. [DOI] [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G; (2008) 'Increased E-cadherin Expression in the Ligated Kidney Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Burke, JP,Ferrante, M,Dejaegher, K,Watson, RWG,Docherty, NG,De Hertogh, G,Vermeire, S,Rutgeerts, P,D'Hoore, A,Penninckx, F,Geboes, K,Van Assche, G,O'Connell, PR; (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, 14 (NA):1197-1204. [DOI] [Details]
O'Connell PR, Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, ; (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, 14 (9):1197-1204. [DOI] [Details]
Quinlan, M. R., Watson, R. W. G., Docherty, N. G., Fitzpatrick, J. M., ; (2008) 'Establishment of an in vitro model of mechanical stretch-induced renal tubular cell apoptosis'. BJU international, 101 :41-41. [Details]
Molloy, EJ,O'Neill, AJ,Grantham-Sloan, JJ,Webb, DW,Watson, RWG; (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Immunology, 151 :244-250. [DOI] [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G; (2008) 'Relative Increases in E-cadherin Expression in Ligated Versus Non-Ligated Kidneys Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Quinlan M.R, Perez-Barriocanal F, Wright E, Dillon-Murphy R, Watson RWG, Fitzpatrick JM and Docherty NG.; (2008) 'Analysis of Urinary and Plasma Electrolytes in a Rat Model of Unilateral Ureteric Obstruction (UUO)'. Open Journal of Urology and Neprology, . [Details]
Daly P, Docherty N.G, Healy D.A, Taylor C.T, Fitzpatrick J.M and Watson R.W.G. ; (2008) 'The Single Insult of Hypoxic Preconditioning induces an Anti-apoptotic Response in Human Proximal Tubular Cells, in vitro, Across Cold Storage'. BJU International, . [Details]
O'Connell PR, Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, ; (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory bowel diseases, (NA). [DOI] [Details]
Dowling, C. M., Claffey, J., Cuffe, S., Fichtner, I., Pampillon, C., Sweeney, N. J., Strohfeldt, K., Watson, R. W. G., Tacke, M., ; (2008) 'Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice'. Letters in Drug Design & Discovery, 5 (2):141-144. [Details]
Burke, JP; Mulsow, JJ; O'Keane, C; Docherty, NG; Watson, RWG; O'Connell, PR; ; (2007) 'Fibrogenesis in Crohn's disease'. American Journal of Gastroenterology, 102 (2):439-448. [Details]
Healy, DG; Watson, RWG; Fitzpatrick, JM; Wood, AE; ; (2007) 'Differential white cell count relationships with human cardiac allograft rejection'. Transplantation Proceedings, 39 (1):218-222. [Details]
Mc Guire, B, Docherty, NG, Fitzpatrick, JM, Watson, RWG, ; (2007) 'Acute ureteric obstruction leads to increased expression of collagen XVIII and endostatin spanning fragment neostatin'. European Urology, 6 :114-114. [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; ; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; ; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Mc Guire, B, Docherty, NG, Fitzpatrick, JM, Watson, RWG, ; (2007) 'Acute ureteric obstruction leads to increased expression of collagen XVIII and endostatin spanning fragment neostatin'. EUR UROL SUPPL, 6 :114-114. [Details]
Burke, JP, Mulsow, JJ, O'Keane, C, Docherty, NG, Watson, RWG, O'Connell, PR, ; (2007) 'Fibrogenesis in Crohn's disease'. The American journal of gastroenterology, 102 (2):439-448. [DOI] [Details]
Bannon, JH,Fichtner, I,O'Neill, A,Pampillon, C,Sweeney, NJ,Strohfeldt, K,Watson, RW,Tacke, M,Mc Gee, MM; (2007) 'Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo'. British Journal of Cancer, 97 :1234-1241. [DOI] [Details]
Perry, AS,Loftus, B,Moroose, R,Lynch, TH,Hollywood, D,Watson, RWG,Woodson, K,Lawler, M; (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. Cancer, 96 :1587-1594. [DOI] [Details]
Hogan, M,Claffey, J,Pampillon, C,Watson, RWG,Tacke, M; (2007) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azole-substituted titanocene anticancer drugs'. Meta, 26 :2501-2506. [DOI] [Details]
Lebret, T,Watson, RWG,Molinie, V,Poulain, JE,O'Neill, A,Fitzpatrick, JM,Botto, H; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. EUR UROL, 51 :161-167. [DOI] [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and neonatal lipopolysaccharide responses are altered in encephalopathy'. American Journal of Perinatology, . [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and Neonatal Lipopolysaccharide and Fas responses are altered by sepsis'. Clinical & Experimental Immunology, . [Details]
Healy DG, Wood AE, O Neill A, McCarthy JF, Fitzpatrick JM, Watson RW. ; (2007) 'Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity'. European Journal of Cardio-Thoracic Surgery, 31 :1088-1093. [Details]
Healy DG, Watson RW, Fitzpatrick JM, Wood AE.; (2007) 'Differential white cell count relationships with human cardiac allograft rejection'. Transplantation Proceedings, 39 (1):218-222. [Details]
Morrissey C, Brown M, O'sullivan J, Weathered N, Watson RW, Tenniswood M.; (2007) 'Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells'. Journal of Urology, 14 (6):545-551. [Details]
Hogan, M., Claffey, J. Pampillón, C., Watson, R. W. G., Tacke, M. ; (2007) 'Synthesis and Cytotoxicity Studies of New Dimethylamino-Functionalized and Azole-Substituted Titanocene Anti-Cancer Drugs'. Organometallics, 26 (10):2501-2506. Available Online [DOI] [Details]
Perry, AS, Loftus, B, Moroose, R, Lynch, TH, Hollywood, D, Watson, RWG, Woodson, K, Lawler, M, ; (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. British Journal of Cancer, 96 :1587-1594. [Details]
Watson RW, Downes MR, Byrne JC, Pennington SR, Dunn MJ, Fitzpatrick JM, ; (2007) 'Urinary markers for prostate cancer'. Bju International, 2 (NA):263-268. [DOI] [Details]
Watson RW, Molloy EJ, O'Neill AJ, Grantham-Sloan JJ, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, ; (2007) 'Neonatal encephalopathy is associated with altered perinatal systemic neutrophil apoptosis'. American journal of perinatology, 9 (NA):525-530. [DOI] [Details]
Hogan, M, Claffey, J, Pampillon, C, Watson, RWG, Tacke, M, ; (2007) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azole-substituted titanocene anticancer drugs'. Organometallics, 26 :2501-2506. [Details]
Watson RW, Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, ; (2007) 'Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms'. Prostate, 15 (NA):1641-1653. [DOI] [Details]
Perrv, A, Loftus, B, Moroose, R, Lynch, T, Hollywood, D, Watson, RWG, Woodson, K, Lawler, M, ; (2007) 'Promoter hypermethylation of IGFBP3 is an early event in prostate carcinogenesis'. EUR UROL SUPPL, 6 :191-191. [Details]
McGuire, BB, Watson, RWG, Perez-Barriocanal, F, Fitzpatrick, JM, Docherty, NG, ; (2007) 'Gender differences in the renin-angiotensin and nitric oxide systems: Relevance in the normal and diseased kidney'. KIDNEY BLOOD PRESS R, 30 :67-80. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, ; (2006) 'Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells'. Apoptosis, 7 (NA):1205-1214. [DOI] [Details]
Healy, D. A.,Daly, P. J.,Docherty, N. G.,Murphy, M.,Fitzpatrick, J. M.,Watson, R. W.; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. J Am Soc Nephrol, 17 (3):805-12. [Details]
Healy D, Watson RWG, O Keane C, O Neill AL, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick JM, Wood AE; (2006) 'Individual variation in early neutrophil infiltration of the allograft influences rejection in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Healy DG, Watson RW, O Keane C, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick J, Wood AE. ; (2006) 'Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 :760-766. [Details]
Molloy EJ, O'Neill AJ, Doyle BT, Grantham J, Taylor Ct, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2006) 'Altered lipopolysaccharide-induced neutrophil responses following hypoxia and heatshock in both adults and neonates in vitro'. Biology of the Neonate, 90 (1):34-39. [Details]
Pennington SR, Downes MR, Byrne JC, Dunn MJ, Fitzpatrick JM, Watson RW, ; (2006) 'Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: a review'. Biomarkers, 5 (NA):406-416. [DOI] [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
Beddy, D; Mulsow, J; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 93 (10):1290-1296. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Quinlan, JF; Watson, RWG; Kelly, G; Kelly, PM; O'Byrne, JM; Fitzpatrick, JM; ; (2006) 'Transforming growth factor-beta (TGF-beta) in acute injuries of the spinal cord'. Journal of Bone and Joint Surgery-British Volume, 88B (3):406-410. [Details]
Gill, C; Walsh, S; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Sensitisation of prostate cancer cells to apoptosis involves altered expression of IAPs and increased caspase activation'. European Urology Supplements, 5 (14):796-796. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology Supplements, 5 (14):797-797. [Details]
Docherty, NG; McGuire, B; O'Sullivan, OE; Watson, RWG; Fitzpatrick, JM; ; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology-Renal Physiology, 290 (5):1202-1212. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology, 17 (3):805-812. [Details]
Docherty, NG; McGuire, B; O'Sullivan, OE; Watson, RWG; Fitzpatrick, JM; ; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology Supplements, 5 (14):789-789. [Details]
Gill, C; Walsh, S; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Sensitisation of prostate cancer cells to apoptosis involves altered expression of IAPs and increased caspase activation'. European Urology Supplements, 5 (14):796-796. [Details]
Quinlan, JF; Watson, RWG; Kelly, G; Kelly, PM; O'Byrne, JM; Fitzpatrick, JM; ; (2006) 'Transforming growth factor-beta (TGF-beta) in acute injuries of the spinal cord'. Journal of Bone and Joint Surgery-British Volume, 88B (3):406-410. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology Supplements, 5 (14):789-789. [Details]
Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; ; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular & Cellular Proteomics, 5 (10):71-71. [Details]
Healy, DG; Watson, RWG; O'Keane, C; Egan, JJ; McCarthy, JF; Hurley, J; Fitzpatrick, J; Wood, AE; ; (2006) 'Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Docherty, NG, McGuire, B, O'Sullivan, OE, Watson, RWG, Fitzpatrick, JM, ; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [DOI] [Details]
Beddy, D; Mulsow, J; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 93 (10):1290-1296. [Details]
Molloy, EJ,O'Neill, AJ,Doyle, BT,Grantham, JJ,Taylor, CT,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 :34-39. [DOI] [Details]
O'Kane, HF,Watson, CJ,Johnston, SR,Petak, I,Watson, RWG,Williamson, KE; (2006) 'Targeting death receptors in bladder, prostate and renal cancer'. Journal of Urology, 175 :432-438. [DOI] [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 10 (NA):1290-1296. [DOI] [Details]
Watson, RWG, O'Neill, A, Brannigan, AE, Coffey, R, Marshall, JC, Brady, HR, Fitzpatrick, JM, ; (2006) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent (vol 453, pg 67, 1999)'. FEBS Letters, 580 (3):996-996. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction'. American Journal of Physiology-Renal Physiology, 290 (1):4-13. [Details]
O'Kane, HF; Watson, CJ; Johnston, SR; Petak, I; Watson, RWG; Williamson, KE; ; (2006) 'Targeting death receptors in bladder, prostate and renal cancer'. Journal of Urology, 175 (2):432-438. [Details]
Docherty, N. G.,O'Sullivan, O. E.,Healy, D. A.,Murphy, M.,O'Neill A, J.,Fitzpatrick, J. M.,Watson, R. W.; (2006) 'TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. Am J Physiol Renal Physiol, 290 (5):F1202-12. [Details]
Docherty, NG; Healy, DA; O'Sullivan, OE; Fitzpatrick, JM; Watson, RWG; ; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Mulsow, JJW; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2005) 'Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling'. Annals of Surgery, 242 (6):880-889. [Details]
Morrissey, C; O'Neill, A; Spengler, B; Christoffel, V; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells'. Prostate, 63 (2):131-142. [Details]
Daly, PJA; Power, RE; Healy, DA; Hickey, DP; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Delayed graft function: a dilemma in renal transplantation'. BJU international, 96 (4):498-501. [Details]
Watson, RWG; Fitzpatrick, JM; ; (2005) 'Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins'. BJU international, 96 (NA):30-34. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Docherty, NG; Healy, DA; O'Sullivan, OE; Fitzpatrick, JM; Watson, RWG; ; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Healy, DG; Watson, RW; O'Neill, AJ; Egan, JJ; McCarthy, JF; Hurley, JP; Fitzpatrick, JM; Wood, AE; ; (2005) 'Cytoimmunological surveillance in human cardiac transplantation with the neutrophil'. British Journal of Surgery, 92 (10):1322-1322. [Details]
Docherty, NG, Healy, DA, O'Sullivan, OE, Fitzpatrick, JM, Watson, RWG, ; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Daly, PJA; Power, RE; Healy, DA; Hickey, DP; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Delayed graft function: a dilemma in renal transplantation'. BJU international, 96 (4):498-501. [Details]
Coffey, RNT,Morrissey, C,Taylor, CT,Fitzpatrick, JM,Watson, RWG; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Cancer, 103 :1363-1374. [DOI] [Details]
Long, RM; Morrissey, C; Hamilton, HJ; Farrell, N; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Prostate epithelial cell differentiation is associated with alterations in apoptotic phenotype'. BJU international, 95 (NA):79-79. [Details]
Long, RM; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies'. Clinical Science, 108 (1):1-11. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Labor induces a maternal inflammatory response syndrome'. American Journal of Obstetrics and Gynecology, 190 (2):448-455. [Details]
Beddy, D.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R.; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. Br J Surg, 91 (1):72-7. Available Online [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [Details]
McEleny, K; Coffey, R; Morrissey, C; Williamson, K; Zangemeister-Wittke, U; Fitzpatrick, JM; Watson, RWG; ; (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 (4):419-425. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
McEleny, K; Coffey, R; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins'. BJU international, 94 (3):402-406. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
Mulsow, J; Watson, RW; Fitzpatrick, JM; O'Connell, R; ; (2004) 'Transforming growth factor-beta mediates increased production of extracellular matrix by intestinal fibroblasts'. British Journal of Surgery, 91 (NA):64-65. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [DOI] [Details]
Morrissey, C,Bektic, J,Spengler, B,Galvin, D,Christoffel, V,Klocker, H,Fitzpatrick, JM,Watson, RWG; (2004) 'Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro'. Journal of Urology, 172 :2426-2433. [DOI] [Details]
Galvin, DJ,Watson, RWG,O'Neill, A,Coffey, RNT,Taylor, C,Gillespie, JI,Fitzpatrick, JM; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Journal of Urology, 23 :342-348. [DOI] [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG; (2004) 'Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. Pediatric Research, 56 :99-103. [DOI] [Details]
O'Neill, AJ,Doyle, BT,Molloy, E,Watson, C,Phelan, D,Greenan, MC,Fitzpatrick, JM,Watson, RWG; (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 :512-518. [DOI] [Details]
McEleny, K,Coffey, R,Morrissey, C,Williamson, K,Zangemeister-Wittke, U,Fitzpatrick, JM,Watson, RWG; (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 :419-425. [DOI] [Details]
Doyle, BT,O'Neill, AJ,Fitzpatrick, JM,Watson, RWG; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 :345-352. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Journal of Urology, 171 (1):457-461. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2004) 'Labour promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. PEDIATRIC RESEARCH, 56 (1):99-103. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RW; (2004) 'Labor induces a maternal inflammatory response syndrome'. Stet, 190 :448-455. [DOI] [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]

Other Journals

Fanning, D.M., Fan, Y., Murphy, B., Klocker, H., Horninger, W., Fitzpatrick, J.M., Watson, R.W.G.; (2010) 'A profile of prostate cancer in Ireland --- development and internal validation of a novel panel of blood biomarkers' Irish Journal of Medical Science 179 (Suppl. 6) :238-239. [Details]
Molloy, E.J., O'Neill, A.J., Doyle, B.T., Grantham, J.J., Taylor, C.T., Sheridan-Pereira, M., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, toll-like receptor-4 and CD11b expression compared with adults' Biology of the Neonate . [Details]

Conference Publications

O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) The British journal of surgery Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]
Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, ; (2009) BJU international Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade [DOI] [Details]
D'Arcy, F., Foley, R., Perry, A., Marignol, L., Lawler, M., Gaffney, E., Watson, R. G. W., Fitzpatrick, J. M., Lynch, T. H., ; (2008) European Urology Supplements No evidence of XMRV in irish prostate cancer patients with the R462q mutation , pp.271-271 [Details]
Dowling, C. M., Cuffe, S., Gill, C., Tacke, M., Fitzpatrick, J. M., Watson, R. W. G., ; (2008) European Urology Supplements Effects of docetaxel and novel titanocene analogues on cell death in prostate cancer following downregulation of Id-1 and the IAPS , pp.276-276 [Details]
Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., ; (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]
Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., ; (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) The British journal of surgery Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease , pp.1290-1296 [DOI] [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, ; (2006) Apoptosis : an international journal on programmed cell death Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells , pp.1205-1214 [DOI] [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson R.W.G.; (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson, R.W.G.; (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research Washington, USA, , 01-APR-06 - 05-APR-06 [Details]
                                                                                         

Research

Research Interests

My focus of research is in prostate cancer which can be divided into two areas:

 

1. Biomarker discovery and validation: Using the critical mass and bioresource facilities of the Prostate Cancer Research Consortium (of which I am the lead PI) the group undertake to address clinically relevant questions to identify and validate biomarkers for grade and stage of prostate cancer which will inform appropriate treatment strategies.

2. Understanding the mechanisms of resistances to therapy of advanced disease. We have established models of resistance to androgen ablation therapy and chemoresistance and using genechip and bioinformatice strategies have identified central transcription factors which represent novel sites for therapeutic manipulation which is carried out as part of the Molecular Therapeutics for Cancer in Ireland SFI cluster and the All Ireland Clinical Oncology Research Group (ICORG)

 

 

Research Projects

Sponsor : The Mater Foundation
Title : To investigate the mechanisms of treatment resistance in advanced Prostate Cancer
Start Date / End Date : 01-JAN-12 / 30-JUN-13
Sponsor : Urology Foundation
Title : Mechanisms of Docetaxel resistance in castrate resistant prostate cancer
Start Date / End Date : 01-JUL-12 / 30-JUN-14
Sponsor : Irish Cancer Society (ICS)
Title : Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
Start Date / End Date : 01-OCT-11 / 31-MAY-15
Sponsor : Health Research Board (HRB)
Title : Validating a panel of serum biomarkers to inform surgical intervention for prostate cancer
Start Date / End Date : 01-JUN-11 / 30-SEP-14
Sponsor : Irish Cancer Society (ICS)
Title : The Identification and Validation of Serum Biomarkers for Biochemical Recurrence in Prostate Cancer
Start Date / End Date : 01-OCT-10 / 30-SEP-13
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents
Start Date / End Date : 01-SEP-09 / 31-MAR-15
   

Collaborators

Internal Collaborators

Professor Stephen Pennington
Proteome Research Centre, Conway Institute, UCD
http://www.ucd.ie/conway/cv_247.html

 Professor Mike Dunn, Proteome Research Centre, Conway Institute, UCD

Professor John Fitzpatrick, Mater Misericordiae University Hospital

External Collaborators

Professor Ralph Buttyan, Department of Urology, Columbia University, USA.
Caspase Activation in prostate epithelial cells during in vivo androgen ablation.

Dr Kate Williamson, Department of Urology, Queens University Belfast.
Oligonucleotides to anti-apoptotic proteins induces apoptotic susceptibility in urological malignancies.

Professor Simon Reif/ Dr. Riena Bornman,Department of Urology, University of Pretoria, South Africa.
Caspase expression in Prostate cancer, differences between a Black and White population.

Professor Helmut Klocker, Department of Urology, University of Innsbruck.
Characterising the apoptotic phenotype of the LNCaP Abl and Hof cell line.

Professor Henry Botto/Dr Thierry Lebret, Department of Urology, Foch Hospital
Interactions between Immune Response Inducted by BCG and Heat Shock Proteins in Superficial bladder cancer.

Professor Mark Lawler and Donal Hollywood, the Prostate Cancer Research Consortium.
Development of new diagnostic, prognostic and therapeutic agents in prostate cancer funded by the Irish Cancer Society.