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Researchers at UCD

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Billy Bourke

Associate Professor

School Of Medicine & Medical Science
Our Lady's Hospital
Crumlin
Dublin 12

Tel: 01 4096272
Email: billy.bourke@ucd.ie

Biography

My main laboratory research interest is in infectious diarrhoeal diseases of childhood and my group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. Together with a group of close collaborators that include Marguerite Clyne, Tadhg O'Croinin and Ulla Knaus at UCD and National Childrens Research Center we have developed an internationally competitive infection biology research programme. We have close collaborative ties with leading national and international scientists in the area of Campylobacter  pathogenesis. The organisms that we study and the laboratory models that we have developed now form the basis for a multi-disciplinary, multi-institutional research drive sponsored by Science Foundation Ireland aimed at understanding the glycobiology of human intestinal infections (Alimentary Glycosciences Research Cluster).

We also have an established track record in clinical epidemiology research on digestive diseases of childhood. Together with Marion Rowland, a clinical epidemiologist recognized internationally for her work on the epidemiology of H. pylori, we have a major research interest in the epidemiology of cystic fibrosis-associated liver disease. These studies, funded by grants from the Health Research Board and The National Childrens Resarch Center, have focussed on understanding the population incidence and risk factors for the development of liver disease and its complications among Irish children with cystic fibrosis

Professional

Honours and Awards

Year: 2005.
Title: Editorial Board of World Journal of Gastroenterology

Associations

Association: American Society for Microbiology, Function/Role: Member
Association: American Gastroenterology Association, Function/Role: Member
Association: North American Society for Gastroenterology, Hepatology & Nutrition, Function/Role: Member
Association: British Society of Gastroenterology, Hepatology & Nutrition, Function/Role: Member
Association: Irish Society of Gastroenterology, Function/Role: Member
       

Committees

Committee : UCD Academic Center for Paediatric Research
Committee : Scientific Advisory Committee, Children's Research Centre
Committee : Health Research Board
Committee : UCD Executive Committee
 

Education

Year 1990 Institution:
Qualification: MRCPI Subject:
Year 1988 Institution: University College Dublin
Qualification: MB, BCh, BAO Subject:
Year 1996 Institution: University College Dublin
Qualification: MD Subject:
Year 1990 Institution: Royal Coll Surgeons in Ireland
Qualification: DCH Subject:
         

Publications

 

Book Chapters

Bourke B, Fleming P, Healy C (2011) 'Crohns disease and orofacial granulomatosis' In: Irvine AD, Hoeger PH, Yan AC (eds). Harpers textbook of pediatric dermatology 3rd Edition. New Jersey: Wiley-Blackwell. , pp.157.1-157.5 [Details]
Marion Rowland, Billy Bourke, Brendan Drumm; (2008) 'Helicobacter pylori and Peptic Ulcer Disease' In: Kleinman, Goulet, Mieli-Vergani, Sanderson, Sherman, Shneider (eds). Walker's Pediatric Gastrointestinal Disease 5. Canada: BC Decker Inc. , pp.139-151 [Details]

Edited Books

Voon L Chan, Philip M Sherman, Billy Bourke (Ed.). (2006) Bacterial Genomes and Infectious Diseases. USA: Humana Press Inc. [Details]

Peer Reviewed Journals

Blackburn C, McDermott M, Bourke B (2012) 'Clinical presentation of and outcome for solitary rectal ulcer syndrome in children'. Journal of Pediatric Gastroenterology and Nutrition, 54 (2):263-265. [Details]
Drumm BR, Bourke B, Drummond J, McNicholas F, Quinn S, Broderick A, Taaffe S, Twomey J, Rowland M (2012) 'Cyclic vomiting syndrome in children:A prospective study'. Neurogastroenterology and Motility, . [Details]
Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, Sullivan JO, Crushell E, Lynch S, Ennis S (2012) 'Identification of a mutation in LARS as a novel cause of infantile hepatopathy'. Molecular Genetics and Metabolism, 106 (3):351-358. [Details]
Alemka A, Corcionivoschi N, Bourke B. (2012) 'Defense and adaptation: The complex inter-relationship between Campylobacter jejuni and mucus'. Frontiers in Cellular and Infection Microbiology, 2 . [Details]
Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B. (2012) 'Mucosal Reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling'. Cell Host and Microbe, 19 :47-59. [Details]
Hope B, Shahdadpuri R, Dunne C, Broderick AM, Grant T, Hamzawi M, O'Driscoll K, Quinn S, Hussey S, Bourke B (2012) 'Rapid rise in incidence of Irish paediatric inflammatory bowel disease'. Archives of Disease in Childhood, 97 (7):590-594. [Details]
Crowley E, Bourke B, Hussey S (2013) 'How to use Helicobacter pylori testing in paediatric practice'. Archives Of Disease In Childhood-Education And Practice Edition, 98 (1):18-25. [Details]
Naughton JA, Mariño K, Dolan B, Reid C, Gough R, Gallagher ME, Kilcoyne M, Gerlach JQ, Joshi L, Rudd P, Carrington S, Bourke B, Clyne M. (2013) 'Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins'. Infection and Immunity, 81 :2838-2850. [Details]
Alvarez LA, Bourke B, Pircalabioru G, Georgiev AY, Knaus UG, Daff S, Corcionivoschi (2013) 'Cj1411c Encodes for a Cytochrome P450 Involved in Campylobacter jejuni 81-176 Pathogenicity'. PLoS ONE, 26 (8). [Details]
Rowland M, Gallagher C, Gallagher CG, Laoide RO, Canny G, Broderick AM, Drummond J, Greally P, Slattery D, Daly L, McElvaney NG, Bourke B (2014) 'Outcome in patients with cystic fibrosis liver disease'. Journal of Cystic Fibrosis, . [Details]
Naughton J, Duggan G, Bourke B, Clyne M. (2014) 'Interaction of microbes with mucus and mucin'. Gut Microbes, 5 (1):48-52. [Details]
Rowland M, Gallagher CG, O'Laoide R, Canny G, Broderick A, Hayes R, Greally P, Slattery D, Daly L, Durie P, Bourke B. ; (2011) 'Outcome in cystic fibrosis liver disease'. American Journal of Gastroenterology, 106 :104-109. [Details]
Russell RK, Wilson ML, Loganathan S, Bourke B, Kiparissi F, Mahdi G, Torrente F, Rodrigues A, Davies I, Thomas A, Akobeng AK, Fagbemi A, Hyer W, Spray C, Vaish S, Rogers P, McGrogan P, Heuschkel RB, Ayub N, Fell JM, Afzal NA, Green M, Murphy MS, Rao P, Shah N, Ho GT, Naik S, Wilson DC. ; (2011) 'A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease'. Alimentary Pharmacology & Therapeutics, 33 :946-953. [Details]
Malik S, Ahmed SF, Wilson ML, Shah N, Loganathan S, NAik S, Bourke B, Thomas A, Akobeng, AK, Fagbemi A, Wilson DC, Russell RK; (2011) 'The effects of Ant-TNF ¿ alpha on growth in children with Crohns disease'. Jornal of Crohns and Colitis, . [Details]
Rowland M, Bourke B. ; (2011) 'Liver disease in cystic fibrosis'. Current Opinion in Pulmonary Medicine, 17 :461-466. [Details]
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B; (2011) 'Disease outcome for children who present with Crohns disease'. European Archives of Paediatric Dentistry, 12 :169-171. [Details]
Rowland M, Fleming P, Bourke B; (2010) 'Looking in the mouth for Crohn's disease'. Inflammatory bowel diseases, 16 :332-337. [DOI] [Details]
2. Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Emerick K, Antoniou A, Wanty C, Fischler B, Jacquemin E, Wali S, Blanchard S, Nielsen IM, Bourke B, McQuaid S, Lacaille F, Byrne JA, van Eerde AM, Kolho KL, Klomp L, Houwen R, Bacchetti P, Lobritto S, Hupertz V, McClean P, Mieli-Vergani G, Shneider B, Nemeth A, Sokal E, Freimer NB, Knisely AS, Rosenthal P, Whitington PF, Pawlowska J, Thompson RJ, Bull LN. ; (2010) 'Differences in presentation and progression between severe FIC1 and BSEP deficiencies'. Journal of Hepatology, 53 :170-178. [Details]
4. Alemka A, Clyne M, Shanahan F, Tompkins T, Corcionivoschi N, Bourke B. ; (2010) 'Probiotic colonisation of mucus-adherent HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties'. Infection and Immunity, 78 :2812-2822. [Details]
3. Alemka A, Whelan S, Gough R, Clyne M, Gallagher ME, Carrington SD, Bourke B. ; (2010) 'Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro'. Journal of Medical Microbiology, 59 :898-903. [Details]
Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor C,J, Wainwright C, Wilschanski M, Zemkova D, Hannah WB, Philips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR,; (2009) 'Genetic modifiers of liver disease in cystic fibrosis'. JAMA, :1076-1083. [Details]
Corcionivoschi N, Clyne M, Lyons A, Gundogdu O, Wren BW, Dorrell N, Karlyshev AV, Bourke B. ; (2009) 'Campylobacter jejuni cocultured with epithelial cells reduces surface capsular polysaccharide expression'. Infect Immun, 77 (5):1959-1967. [Details]
Fitzpatrick, E.,Bourke, B.,Drumm, B.,Rowland, M.; (2007) 'Outcome for children with cyclical vomiting syndrome'. Arch Dis Child, 92 (11):1001-4. [Details]
Croinin, T. O.,McCormack, A.,van Vliet, A. H.,Kusters, J. G.,Bourke, B.; (2007) 'Random mutagenesis to identify novel Helicobacter mustelae virulence factors'. FEMS Immunol Med Microbiol, 50 (2):257-63. [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2007) 'Outcome for children with cyclical vomiting syndrome'. Archives of Disease in Childhood, 92 (11):1001-1004. [DOI] [Details]
Rowland, M,Daly, L,Vaughan, M,Higgins, A,Bourke, B,Drumm, B; (2006) 'Age-Specific incidence of Helicobacter pylori'. GASTROENTEROLOGY, 130 (NA):65-72. [DOI] [Details]
Bourke B, Corbett K, Kelleher S, Rowland M, Daly L, Drumm B, Canny G, Greally P, Hayes R, ; (2004) 'Cystic fibrosis-associated liver disease: a population-based study'. Pediatrics, 3 (NA):327-332. [DOI] [Details]
Bourke B, Crushell E, Harty S, Sharif F, ; (2004) 'Enteric campylobacter: purging its secrets?'. Pediatric Research, 55 (1):3-12. [DOI] [Details]
Bourke B, Mooney A, Byrne C, Clyne M, Johnson-Henry K, Sherman P, ; (2003) 'Invasion of human epithelial cells by Campylobacter upsaliensis'. Cellular Microbiology, 5 (11):835-847. [Details]
Drumm B, Bourke B, ; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Archives of Disease in Childhood, 86 (2):71-72. [Details]
Bourke B, ; (2002) 'Campylobacter infection: small bowel and colon'. Current opinion in gastroenterology, 18 (1):4-9. [Details]
Drumm B, Imrie C, Rowland M, Bourke B, ; (2001) 'Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?'. Pediatrics, 107 (2):373-380. [Details]
Bourke B, Mooney A, Clyne M, Curran T, Doherty D, Kilmartin B, ; (2001) 'Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes'. Microbiology (Reading, England), 147 (Pt 3):735-743. [Details]
Bourke B, Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, ; (2001) 'The oral cavity in Crohn's disease'. Pediatrics, 138 (5):767-771. [DOI] [Details]
Bourke B, Sharif F, Crushell E, O'Driscoll K, ; (2001) 'Liquid paraffin: a reappraisal of its role in the treatment of constipation'. Archives of Disease in Childhood, 85 (2):121-124. [Details]
Jones NL, Bourke B, ; (2001) 'Pathogenesis of Helicobacter pylori infection'. Current opinion in gastroenterology, 17 (1):24-29. [Details]
Sherman PM, Bourke B, ; (1999) 'Gastrointestinal infections in children'. Current opinion in gastroenterology, 15 (1):79-84. [Details]
Drumm B, Rowland M, Imrie C, Bourke B, ; (1999) 'How should Helicobacter pylori infected children be managed?'. Gut, 45 Suppl 1 (NA):1-9. [Details]
Sherman P, Bourke B, Chan VL, ; (1998) 'Campylobacter upsaliensis: waiting in the wings'. Clinical Microbiology Reviews, 11 (3):440-449. [Details]
Drumm B, Bourke B, Goggin N, Walsh D, Kennedy S, Setchell KD, ; (1996) 'Byler-like familial cholestasis in an extended kindred'. Archives of Disease in Childhood, 75 (3):223-227. [Details]
Drumm B, Bourke B, Sherman P, ; (1994) 'Peptic ulcer disease: what is the role for Helicobacter pylori?'. Seminars in gastrointestinal disease, 5 (1):24-31. [Details]
McDermott M, Hussey S, Bourke B, Broderick A, Phelan E, ; (2008) 'Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy'. Journal of Pediatric Gastroenterology and Nutrition, 47 (1):107-109. [DOI] [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2008) 'The incidence of cyclic vomiting syndrome in children: population-based study'. American Journal of Gastroenterology, 103 (4):991-91. [DOI] [Details]
Byrne CM, Clyne M, Bourke B. ; (2007) 'Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro'. Microbiology, 153 pt. 2 :561-569. [Details]
Hashim, A., Mulchy, G., Bourke, B., Clyne, M.; (2006) 'Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells'. INFECTION AND IMMUNITY, 74 (1):99-107. [Details]
Rowland M, Broderick A, Bourke B. ; (2006) 'Behavioral and nutritional treatment to improve energy intake and growth in toddlers and preschool-aged children with cystic fibrosis'. Paediatrics, 118 (1):432-433. [Details]
Bourke B, Broderick A, Bohane T. ; (2006) 'Peutz-Jeghers syndrome and management recommendations'. Clinical Gastroenterology and Hepatology, 12 . [Details]
Finn SM, Rowland M, Lawlor F, Kinsella W, Chan L, Byrne O, O'Mahony O, Bourke B. ; (2006) 'The significance of cutaneous spider naevi in children'. Archives of Disease in Childhood, 91 (7):604-605. [Details]
Rowland M, Bourke B, Drumm B. ; (2005) 'Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (Supp 1):S32-S33. [Details]
Harty S, Fleming P, Rowland M, Crushell E, McDermott M, Drumm B, Bourke B. ; (2005) 'A prospective study of the oral manifestations of Crohns disease'. Clinical Gastroenterology and Hepatology, 3 :886-891. [Details]
Bourke B. ; (2005) 'Will treatment of Helicobacter pylori infection in childhood alter the risk of developing gastric cancer?'. Canadian Journal of Gastroenterology, 19 (7):409-411. [Details]
Bourke B, Ceponis P, Chiba N, Czinn S, Ferraro R, Fischbach L, Gold B,Hyunh H, Jacobson K, Jones NL, Koletzko S, Lebel S, Moayyedi P, Ridell R,Sherman P, van Zanten S, Beck I, Best L, Boland M, Bursey F, Chaun H, Cooper G,Craig B, Creuzenet C, Critch J, Govender K, Hassall E, Kaplan A, Keelan M, Noad G, Robertson M, Smith L, Stein M, Taylor D, Walters T, Persaud R, Whitaker S,Woodland; Canadian Helicobacter Study Group. ; (2005) 'Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation'. Canadian Journal of Gastroenterology, 19 (7):399-408. [Details]
Crushell E, Hartey S, Sharif F, Bourke B.; (2004) 'Enteric Campylobacter - Purging its secrets?'. Paediatric Research, (55):3-12. [Details]
Hashim A, Clyne M, Mulcahy G, D Akiyoshi, R Chalmers, Bourke B. ; (2004) 'Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes'. Infection and Immunity, 72 :6125-6131. [Details]
Corbett K, Kelleher S, Rowland M, Daly L, Drumm B, Canny G, Greally P, Hayes R, Bourke B.; (2004) 'Cystic fibrosis-associated liver disease: A population-based study'. Journal of Paediatrics, 145 :327-332. [Details]
Mooney A, Byrne C, Clyne M, Johnson-Henry K, Sherman P, Bourke B; (2003) 'Invasion of human epithelial cells by Campylobacter upsaliensis'. Cellular Microbiology, 5 :835-847. [Details]
Crushell E, Rowland M, Doherty M, Gormally S, Harty S, Bourke B, Drumm B. ; (2003) 'Importance of parental conceptual model of illness in severe recurrent abdominal pain'. Paediatrics, (112):1368-1372. [Details]
Bourke B.; (2002) 'Campylobacter infection: small bowel and colon'. Curr Opin Gastroenterol, 18 (4). [Details]
Sharif F, McDermott M, Dillon M, Rowland M, Kelleher S, Drumm B, Bourke B. ; (2002) 'Focally enhanced gastritis in Crohn disease and ulcerative colitis'. American Journal of Gastroenterology, 97 :1415-1420. [Details]
Pittock S, Drumm B, Fleming P, McDermott M, Imrie I, Flint, S, Bourke B. ; (2001) 'The oral cavity in Crohn disease'. J Pediatr, (138):767-771. [Details]
Mooney A, Clyne M, Curran T, Doherty D, Kilmartin B, Bourke B. ; (2001) 'Campylobacter upsaliensis exerts cytolethal distending toxin effect on HeLa cells and T lymphocytes'. Microbiology, (47):735-743. [Details]
Byrne C, Doherty D, MooneyM, Byrne M, Woodward D, Johnson W, Rogers F, Bourke B. ; (2001) 'Basis of the superiority of cefoperazone amphotericin teicoplainin (CAT) for isolating Campylobacter upsaliensisfrom stools?'. Journal of Clinical Microbiology, (39):2713-2716. [Details]
                                                                                             

Research

Research Interests

My main laboratory research interest is in infectious diarrhoeal diseases of childhood and my group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. Together with a group of close collaborators that include Marguerite Clyne, Tadhg O'Croinin and Ulla Knaus at UCD and National Childrens Research Center we have developed an internationally competitive infection biology research programme. We have close collaborative ties with leading national and international scientists in the area of Campylobacter  pathogenesis. The organisms that we study and the laboratory models that we have developed now form the basis for a multi-disciplinary, multi-institutional research drive sponsored by Science Foundation Ireland aimed at understanding the glycobiology of human intestinal infections (Alimentary Glycosciences Research Cluster).

We also have an established track record in clinical epidemiology research on digestive diseases of childhood. Together with Marion Rowland, a clinical epidemiologist recognized internationally for her work on the epidemiology of H. pylori, we have a major research interest in the epidemiology of cystic fibrosis-associated liver disease. These studies, funded by grants from the Health Research Board and The National Childrens Resarch Center, have focussed on understanding the population incidence and risk factors for the development of liver disease and its complications among Irish children with cystic fibrosis


FUNDING AGENCIES:
Health Research Board
Children's Medical & Research Foundation
Science Foundation Ireland

Research Projects

Sponsor : Health Research Board (HRB)
Title : The Role of Carbohydrates in Mediating Adherence and Invasion of Campylobacter Jejuni to Intestinal Cells
Start Date / End Date : 08-JUN-10 / 03-AUG-10
Sponsor : Health Research Board (HRB)
Title : The Natural History of Cystic Fibrosis Liver Disease- Refining the Phenotype
Start Date / End Date : 06-OCT-14 / 05-OCT-17
Sponsor : University College Dublin (UCD)
Title : The interaction of pathogenic organism with mucosal surfaces and epithelial cells
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin (UCD)
Title : Investigation of the role played by DNA supercoiling in the regulation of virulence genes of C. jejuni
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Enterprise Ireland (EI)
Title : cDNA Representational difference analysis to explore temperature regulated gene transcription in the food-borne pathogen campylobacter
Start Date / End Date : 01-OCT-01 / 30-SEP-03
Sponsor : Science Foundation Ireland (SFI)
Title : The role and regulation of bacterial capsular polysaccharide in the pathogenesis of Campylobacter infection
Start Date / End Date : 01-NOV-05 / 28-FEB-10
 

Current Postgraduate Students

Lucy Connolly, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Collaborators

Internal Collaborators


Professor Ulla Knaus
Dr Marguerite Clyne  
Dr MArion Rowland  
Dr Tadhg O'Croinin
Dr Nicolae Corcionivoschi -
Dr Luis Alvarez
Dr Letal Salzberg