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Researchers at UCD

Brendan Drumm

Professor of Paediatrics

School Of Medicine & Medical Science
Health Sciences Centre
Belfield
Dublin 4

Tel: +353 1 7166604
Email: brendan.drumm@ucd.ie

Biography

Professor Drumm, undertook his medical studies at University College Galway and graduated in 1979.

 

In 1981 he started his postgraduate clinical training at the Hospital for Sick Children in Toronto where he was subsequently appointed Consultant Paediatric Gastroenterologist and Assistant Professor of Pediatrics at the University of Toronto.

 

In 1990 he was appointed Professor and Head of the Department of Paediatrics at University College Dublin and Consultant Paediatric Gastroenterologist at Our Lady's Children¿s Hospital in Dublin, where he established a paediatric Gastroenterology research unit. This research unit,which includes Dr Marguerite Clyne, Prof Billy Bourke and Dr Marion Rowland is recognised internationally as a leader in research in  gastrointestinal diseases in childhood.

 

Professor Drumm has over 100 research reports, book chapters and reviews published.  The ranking of his research internationally is confirmed by publications on several occasions in prestigious journals such as the New England Journal of Medicine, The Lancet, Gastroenterology, The Journal of Clinical Investigation and the Proceedings of the National Academy of Sciences.

 

His research has been supported by grants from agencies varying from the Wellcome Trust in the UK, to the European Union, American Gastroenterology Association, Irish Health Research Board, Medical Research Council of Canada and the Children¿s Research Foundation.

 

Professor Drumm has been an invited speaker for National Colleges of Physicians and National Gastroenterology associations across the world including the United States, England, Canada, Scotland, Holland and Australia, and has been a guest speaker at Universities in over 20 countries.

 

In 2005 the Irish Government appointed Professor Drumm as the first CEO of the Health Service Executive (HSE) in Ireland  for a five year term.

 

The HSE was established to unify and manage the health and personal social care services in Ireland. Before 2005 services were provided through a series of unconnected agencies and health boards. 

 

The HSE employs 110,000 people and has an annual budget of approximately 15 billon euro.

 

As CEO, Professor Drumm led the largest public service Transformation Programme ever undertaken in Ireland.

 

This Programme concentrated on building an integrated healthcare service that delivers the vast majority of care to patients and clients in their own homes or as close to their home as possible. 

 

The major building blocks included:

·        A major hospital reconfiguration programme.

·        A national network of comprehensive Primary Care Teams.

·        Developing clinical leadership focused on improving access, quality and value at national, regional and local level.

·        Developing a comprehensive performance management system

·        Value for money and cost containment initiatives that enabled cost reductions of over 1 billion euros and significant service level increases across all areas. 

 

!n 2011 he returned to University College Dublin. He is developing programmes focused on promoting clinicians as leaders of change in the provision of health care internationally. He has a particular interest in changing the provision of health services to try and ensure that care and healing are as important as investigating, treating and curing patients.

 

He is a Fellow of the Royal Colleges of Physicians in Canada, Ireland and the UK, and was in the first group of Gastroenterologists awarded with a fellowship of the American Gastroenterology Association in 2008 in recognition of his contribution to research in gastrointestinal disease.

For more information about Professor Brendan Drumm see brendandrumm.com

Publications

     

Peer Reviewed Journals

Sharif, F., McDermott, M., Dillon, M., Rowland, M., Kelleher, S., Drumm, B., and Bourke, B.; (0) 'Focally enhanced gastritis in Crohn disease and ulcerative colitis'. American Journal of Gastroenterology, . [Details]
Drumm, B., Sherman, P., Cutz, E., and Karmali, M.; (1987) 'Association of Campylobacter pylori0 on the Gastric Mucosa with Antral Gastritis in Children'. 316 :1557-1561. [Details]
Drumm, B., Perez-Perez, G., Blaser, M., and Sherman, P.; (1990) 'Intrafamilial clustering of Helicobacter pylori0 infection'. Then New England Journal of Medicine, 312 :359-363. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS'. Gastroenterology, 104 (4):56-56. [Details]
LAMBERT, I, CLYNE, M, DRUMM, B, ; (1993) 'HELICOBACTER-PYLORI IN DENTAL PLAQUES'. Lancet, 341 (8850):957-957. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'CHARACTERIZATION OF BINDING OF HELICOBACTER-PYLORI TO A GASTRIC ADENOCARCINOMA CELL-LINE'. Gastroenterology, 104 (4):57-57. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS'. Infection and Immunity, 61 (10):4051-4057. [Details]
CLYNE, M,DRUMM, B; (1993) 'ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS'. Infection and Immunity, 61 :4051-4057. [Details]
DRUMM, B; (1993) 'HELICOBACTER-PYLORI IN THE PEDIATRIC-PATIENT'. Gastroenterology, 22 :169-182. [Details]
Clyne M, Drumm B. ; (1993) 'Adherence of Helicobacter pylori to primary human gastrointestinal cells'. Infection and Immunity, 61 (10):4051-4057. [Details]
GORMALLY, SM; BAKER, A; PORTMANN, B; MOWAT, A; DRUMM, B; ; (1994) 'HIGH WATER COPPER CONTENT ASSOCIATED WITH INDIAN CHILDHOOD CIRRHOSIS IN EUROPEAN CHILDREN'. Gastroenterology, 106 (4):900-900. [Details]
Drumm B, Bourke B, Sherman P, ; (1994) 'Peptic ulcer disease: what is the role for Helicobacter pylori?'. Seminars in gastrointestinal disease, 5 (1):24-31. [Details]
CLYNE, M; DRUMM, B; ; (1994) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Gastroenterology, 106 (4):666-666. [Details]
CLYNE, M, DRUMM, B, ; (1994) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Gastroenterology, 106 (4):666-666. [Details]
SHABIB, SM,CUTZ, E,DRUMM, B,SHERMAN, PM; (1994) 'ASSOCIATION OF GASTRIC METAPLASIA AND DUODENITIS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. J Clin Pathol, 102 :188-191. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, M; DALY, L; KIERCE, B; DRUMM, B; ; (1994) 'SYMPTOMS IN CHILDREN BEFORE AND AFTER TREATMENT OF HELICOBACTER-PYLORI INFECTION'. Gastroenterology, 106 (4):83-83. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, M; DALY, L; KIERCE, B; DRUMM, B; ; (1994) 'SYMPTOMS IN CHILDREN BEFORE AND AFTER TREATMENT OF HELICOBACTER-PYLORI INFECTION'. Gastroenterology, 106 (4):83-83. [Details]
CLYNE, M; LABIGNE, A; DRUMM, B; ; (1995) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Infection and Immunity, 63 (5):1669-1673. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, MT; DALY, LE; CLYNE, M; KIERCE, BM; DRUMM, B; ; (1995) 'ASSOCIATION OF SYMPTOMS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. Pediatrics, 126 (5):753-756. [Details]
EISENSTAT, DDR; GRIFFITHS, AM; CUTZ, E; PETRIC, M; DRUMM, B; ; (1995) 'ACUTE CYTOMEGALOVIRUS-INFECTION IN A CHILD WITH MENETRIERS DISEASE'. Gastroenterology, 109 (2):592-595. [Details]
CLYNE, M; DRUMM, B; ; (1995) 'THE UREASE ENZYME OF HELICOBACTER-PYLORI DOES NOT FUNCTION AS AN ADHESIN'. Gastroenterology, 108 (4):798-798. [Details]
Clyne, M., and Drumm B.; (1995) '\i Helicobacter pylori0 requires an Acidic Environment to survive in the Presence of Urea'. Infection and Immunity, 63 :1669-1673. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, MT; DALY, LE; CLYNE, M; KIERCE, BM; DRUMM, B; ; (1995) 'ASSOCIATION OF SYMPTOMS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. Pediatrics, 126 (5):753-756. [Details]
ABUBAKAR, K,GOGGIN, N,GORMALLY, S,DURNIN, M,DRUMM, B; (1995) 'PREPARING THE BOWEL FOR COLONOSCOPY'. Childhood, 73 :459-461. [Details]
CLYNE, M, LABIGNE, A, DRUMM, B, ; (1995) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Infection and Immunity, 63 (5):1669-1673. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, MT; DALY, LE; CLYNE, M; KIERCE, BM; DRUMM, B; ; (1995) 'ASSOCIATION OF SYMPTOMS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. Pediatrics, 126 (5):753-756. [Details]
CLYNE, M, DRUMM, B, ; (1995) 'THE UREASE ENZYME OF HELICOBACTER-PYLORI DOES NOT FUNCTION AS AN ADHESIN'. Gastroenterology, 108 (4):798-798. [Details]
CLYNE, M, THOMAS, J, DRUMM, B, ; (1995) 'EFFECT OF BREAST-MILK AND SPECIFIC ANTIBODIES ON ADHERENCE OF HELICOBACTER-PYLORI'. Gastroenterology, 108 (4):798-798. [Details]
CLYNE, M,LABIGNE, A,DRUMM, B; (1995) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Infection and Immunity, 63 :1669-1673. [Details]
CLYNE, M; THOMAS, J; DRUMM, B; ; (1995) 'EFFECT OF BREAST-MILK AND SPECIFIC ANTIBODIES ON ADHERENCE OF HELICOBACTER-PYLORI'. Gastroenterology, 108 (4):798-798. [Details]
ABUBAKAR, K; GOGGIN, N; GORMALLY, S; DURNIN, M; DRUMM, B; ; (1995) 'PREPARING THE BOWEL FOR COLONOSCOPY'. Archives of Disease in Childhood, 73 (5):459-461. [Details]
Drumm B, Bourke B, Goggin N, Walsh D, Kennedy S, Setchell KD, ; (1996) 'Byler-like familial cholestasis in an extended kindred'. Archives of Disease in Childhood, 75 (3):223-227. [Details]
Clyne, M, Drumm, B, ; (1996) 'Cell envelope characteristics of Helicobacter pylori: Their role in adherence to mucosal surfaces and virulence'. Fems Immunology and Medical Microbiology, 16 (2):141-155. [Details]
Clyne, M; Drumm, B; ; (1996) 'The urease enzyme of Helicobacter pylori does not function as an adhesin'. Infection and Immunity, 64 (7):2817-2820. [Details]
Bourke, B; Goggin, N; Walsh, D; Kennedy, S; Setchell, KDR; Drumm, B; ; (1996) 'Byler-like familial cholestasis in an extended kindred'. Archives of Disease in Childhood, 75 (3):223-227. [Details]
Clyne, M,Drumm, B; (1996) 'The urease enzyme of Helicobacter pylori does not function as an adhesin'. Infection and Immunity, 64 :2817-2820. [Details]
Gormally, SM, Kierce, BM, Daly, LE, Bourke, B, Carroll, R, Durnin, MT, Drumm, B, ; (1996) 'Gastric metaplasia and duodenal ulcer disease in children infected by Helicobacter pylori'. Gut, 38 (4):513-517. [Details]
Gormally, SM,Kierce, BM,Daly, LE,Bourke, B,Carroll, R,Durnin, MT,Drumm, B; (1996) 'Gastric metaplasia and duodenal ulcer disease in children infected by Helicobacter pylori'. Gut, 38 :513-517. [Details]
Clyne, M; Drumm, B; ; (1996) 'Cell envelope characteristics of Helicobacter pylori: Their role in adherence to mucosal surfaces and virulence'. Fems Immunology and Medical Microbiology, 16 (2):141-155. [Details]
OCroinin, T; Clyne, M; Drumm, B; ; (1997) 'Helicobacter mustelae specific antibodies cross react with ferret gastric tissue'. Gastroenterology, 112 (4):1054-1054. [Details]
Rowland, M; Kumar, D; OConnor, P; Daly, LE; Drumm, B; ; (1997) 'Reinfection with Helicobacter pylori in children'. Gastroenterology, 112 (4):273-273. [Details]
Clyne, M, Thomas, J, Weaver, L, Drumm, B, ; (1997) 'In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells'. Gut, 40 (6):731-738. [Details]
Rowland, M, Lambert, I, Gormally, S, Daly, LE, Thomas, JE, Hetherington, C, Durnin, M, Drumm, B, ; (1997) 'Carbon 13 - Labeled urea breath test for the diagnosis of Helicobacter pylori infection in children'. Pediatrics, 131 (6):815-820. [Details]
OCroinin, T; Clyne, M; Drumm, B; ; (1997) 'Helicobacter mustelae specific antibodies cross react with ferret gastric tissue'. Gastroenterology, 112 (4):1054-1054. [Details]
Clyne M, Thomas J, Weaver L, Drumm B.; (1997) 'In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells'. Gut, 40 (6):731-738. [Details]
Clyne M., and Drumm B.; (1997) 'Absence of effect of Lewis A and Lewis B blood group antigen expression on adherence of Helicobacter pylori to gastric cells'. Gastroenterology, 113 :72-80. [Details]
Rowland M, Kumar D, O'Connor P, Daly LE, Drumm B. ; (1997) 'Reinfection with Helicobacter pylori in children'. GASTROENTEROLOGY, 112 (4):273-273. [Details]
Clyne, M,Thomas, J,Weaver, L,Drumm, B; (1997) 'In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells'. Gut, 40 :731-738. [Details]
Clyne, M,Drumm, B; (1997) 'Absence of effect of Lewis a and Lewis B expression on adherence of Helicobacter pylori to human gastric cells'. Gastroenterology, 113 :72-80. [Details]
Rowland, M,Lambert, I,Gormally, S,Daly, LE,Thomas, JE,Hetherington, C,Durnin, M,Drumm, B; (1997) 'Carbon 13 - Labeled urea breath test for the diagnosis of Helicobacter pylori infection in children'. Pediatrics, 131 :815-820. [Details]
Walsh, D,Drumm, B; (1997) 'Helicobacter pylori: challenges for the paediatrician'. Journal of Paediatrics and Child Health, 33 :469-470. [Details]
Clyne, M, Drumm, B, ; (1997) 'Absence of effect of Lewis a and Lewis B expression on adherence of Helicobacter pylori to human gastric cells'. Gastroenterology, 113 (1):72-80. [Details]
Clyne, M, Covacci, A, Drumm, B, Crabtree, JE, ; (1997) 'Adherence of Helicobacter pylori to gastric epithelial cells and induction of interleukin-8'. Gut, 41 (NA):110-110. [Details]
Clyne, M; Drumm, B; ; (1997) 'Absence of effect of Lewis a and Lewis B expression on adherence of Helicobacter pylori to human gastric cells'. Gastroenterology, 113 (1):72-80. [Details]
Clyne, M; Covacci, A; Drumm, B; Crabtree, JE; ; (1997) 'Adherence of Helicobacter pylori to gastric epithelial cells and induction of interleukin-8'. Gut, 41 (NA):110-110. [Details]
Rowland, M; Kumar, D; OConnor, P; Daly, LE; Drumm, B; ; (1997) 'Reinfection with Helicobacter pylori in children'. Gut, 41 (NA):33-33. [Details]
Rowland, M; Kumar, D; OConnor, P; Daly, LE; Drumm, B; ; (1997) 'Reinfection with Helicobacter pylori in children'. Gut, 41 (NA):1-1. [Details]
Walsh, D; Drumm, B; ; (1997) 'Helicobacter pylori: challenges for the paediatrician'. Journal of Paediatrics and Child Health, 33 (6):469-470. [Details]
Clyne, M; Drumm, B; ; (1998) 'No correlation between H-pylori and blood groups in gastric cancer - Reply'. Gastroenterology, 114 (3):621-621. [Details]
Croinin, TO; Clyne, M; Drumm, B; ; (1998) 'Molecular mimicry of ferret gastric epithelial blood group antigen a by Helicobacter mustelae'. Gastroenterology, 114 (4):690-696. [Details]
Dillon, M; Brown, S; Casey, W; Walsh, D; Durnin, M; Abubaker, K; Drumm, B; ; (1998) 'Colonoscopy under general anesthesia in children'. Pediatrics, 102 (2):381-383. [Details]
O Croinin T, Clyne M and Drumm B; (1998) 'Molecular Mimicry of Ferret Gastric Epithelial Blood Group Antigen A by Helicobacter mustelae'. GASTROENTEROLOGY, 114 :690-696. [Details]
Goggin, N; Rowland, N; Imrie, C; Walsh, D; Clyne, M; Drumm, B; ; (1998) 'Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease'. Archives of Disease in Childhood, 79 (6):502-505. [Details]
Croinin, TO; Clyne, M; Drumm, B; ; (1998) 'Molecular mimicry of ferret gastric epithelial blood group antigen a by Helicobacter mustelae'. Gastroenterology, 114 (4):690-696. [Details]
Clyne, M, Drumm, B, ; (1998) 'No correlation between H-pylori and blood groups in gastric cancer - Reply'. Gastroenterology, 114 (3):621-621. [Details]
Rowland M, Lambert I, Gormally S, Daly LE, Thomas JE, Hetherington C, Durnin M, Drumm B. ; (1998) 'C-13 urea breath test for the diagnosis of Helicobacter pylori in children'. GUT, 43 (NA):8-8. [Details]
Croinin, TO,Clyne, M,Drumm, B; (1998) 'Molecular mimicry of ferret gastric epithelial blood group antigen a by Helicobacter mustelae'. Gastroenterology, 114 :690-696. [Details]
Rowland, M,Drumm, B; (1998) 'Clinical significance of Helicobacter infection in children'. British Medical Bulletin, 54 :95-103. [Details]
Dillon, M,Brown, S,Casey, W,Walsh, D,Durnin, M,Abubaker, K,Drumm, B; (1998) 'Colonoscopy under general anesthesia in children'. Pediatrics, 102 :381-383. [Details]
Rowland, M; Lambert, I; Gormally, S; Daly, LE; Thomas, JE; Hetherington, C; Durnin, M; Drumm, B; ; (1998) 'C-13 urea breath test for the diagnosis of Helicobacter pylori in children'. Gut, 43 (NA):8-8. [Details]
Goggin, N; Rowland, N; Imrie, C; Walsh, D; Clyne, M; Drumm, B; ; (1998) 'Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease'. Archives of Disease in Childhood, 79 (6):502-505. [Details]
Vaughan, D; Drumm, B; ; (1999) 'Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease'. New England Journal of Medicine, 340 (3):239-240. [Details]
Clyne, M; O Croinin, T; Drumm, B; ; (1999) 'Mimicry of blood group antigen A by Helicobacter mustelae and H-pylori - Reply'. Gastroenterology, 116 (2):505-505. [Details]
Drumm B, Rowland M, Imrie C, Bourke B, ; (1999) 'How should Helicobacter pylori infected children be managed?'. Gut, 45 Suppl 1 (NA):1-9. [Details]
Clyne M, O Croinin T, Drumm B, Moran A, Hynes S, Henegan M.; (1999) 'Mimicry of Blood group Antigen A by Helicobacter mustelae and Helicobacter pylori'. GASTROENTEROLOGY, 116 (2). [Details]
Rowland, M., Kumar, D., Daly, L., OConnor, P., Vaughan, D., and Drumm, B.; (1999) 'Low rates of Helicobacter pylori0 reinfection in children'. Gastroenterology, 117 :336-341. [Details]
Clyne, M, O Croinin, T, Drumm, B, ; (1999) 'Mimicry of blood group antigen A by Helicobacter mustelae and H-pylori - Reply'. Gastroenterology, 116 (2):505-505. [Details]
Bull, LN; Juijn, JA; Liao, M; van Eijk, MJT; Sinke, RJ; Stricker, NL; DeYoung, JA; Carlton, VEH; Baharloo, S; Klomp, LWJ; Abukawa, D; Barton, DE; Bass, NM; Bourke, B; Drumm, B; Jankowska, I; Lovisetto, P; McQuaid, S; Pawlowska, J; Tazawa, Y; Villa, E; Tygstrup, N; Berger, R; Knisely, AS; Houwen, RHJ; Freimer, NB; ; (1999) 'Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC'. Human Genetics, 104 (3):241-248. [Details]
Vaughan, D,Imrie, C,Kelleher, J,Drumm, B,Osborne, H; (1999) 'Pancreatic duct stenting as a treatment for hereditary pancreatitis'. Pediatrics, 104 :1129-1133. [Details]
Rowland, M,Kumar, D,Daly, L,O'Connor, P,Vaughan, D,Drumm, B; (1999) 'Low rates of Helicobacter pylori reinfection in children'. Gastroenterology, 117 :336-341. [Details]
Rowland, M, Kumar, D, Daly, L, O'Connor, P, Vaughan, D, Drumm, B, ; (1999) 'Low rates of Helicobacter pylori reinfection in children'. Gastroenterology, 117 (2):336-341. [Details]
Bull, LN,Juijn, JA,Liao, M,van Eijk, MJT,Sinke, RJ,Stricker, NL,DeYoung, JA,Carlton, VEH,Baharloo, S,Klomp, LWJ,Abukawa, D,Barton, DE,Bass, NM,Bourke, B,Drumm, B,Jankowska, I,Lovisetto, P,McQuaid, S,Pawlowska, J,Tazawa, Y,Villa, E,Tygstrup, N,Berger, R,Knisely, AS,Houwen, RHJ,Freimer, NB; (1999) 'Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC'. Gene, 104 :241-248. [Details]
Vaughan, D; Imrie, C; Kelleher, J; Drumm, B; Osborne, H; ; (1999) 'Pancreatic duct stenting as a treatment for hereditary pancreatitis'. Pediatrics, 104 (5):1129-1133. [Details]
Bourke, B; Drumm, B; ; (2000) 'The efficacy of cisapride; Time to review not regurgitate'. Journal of Pediatric Gastroenterology and Nutrition, 30 (3):230-230. [Details]
Clyne, M; Ocroinin, T; Suerbaum, S; Josenhans, C; Drumm, B; ; (2000) 'Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells'. Infection and Immunity, 68 (7):4335-4339. [Details]
Clyne M, Ocroinin T, Suerbaum S, Josenhans C, Drumm B. ; (2000) 'Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells'. Infection and Immunity, 68 (7). [Details]
Clyne, M, OCroinin, T, Drumm, B, ; (2000) 'Adherence mechanism of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric cells'. Gut, 47 (NA):1-1. [Details]
Clyne, M,Ocroinin, T,Suerbaum, S,Josenhans, C,Drumm, B; (2000) 'Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells'. Infection and Immunity, 68 :4335-4339. [Details]
OCroinin, T; Clyne, R; Drumm, B; ; (2000) 'Helicobacter mustelae infection of the ferret as a natural animal model for Helicobacter adherence studies'. Gut, 47 (NA):4-4. [Details]
Clyne, M; OCroinin, T; Drumm, B; ; (2000) 'Adherence mechanism of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric cells'. Gut, 47 (NA):1-1. [Details]
Croinin, TO; Heerma, SB; Drumm, B; Vandenbroucke-Grauls, CMJ; Bourke, B; Kusters, JG; ; (2000) 'Identification of Helicobacter mustelae virulence factors by screening of a random insertional mutant library'. Gut, 47 (NA):62-63. [Details]
Rowland, M; Drumm, B; ; (2001) 'Helicobacter pylori and sudden-infant-death syndrome'. Lancet, 357 (9253):327-327. [Details]
Oderda, G; Cadranel, S; Drumm, B; Koletzko, S; ; (2001) 'Announcing the creation of the Paediatric European Register for Treatment of Helicobacter pylori (PERTH)'. Journal of Pediatric Gastroenterology and Nutrition, 33 (5):526-527. [Details]
Imrie, C; Rowland, M; Bourke, B; Drumm, B; ; (2001) 'Limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants'. Pediatrics, 139 (5):734-737. [Details]
Pittock, S; Drumm, B; Fleming, P; McDermott, M; Imrie, C; Flint, S; Bourke, B; ; (2001) 'The oral cavity Crohn's disease'. Pediatrics, 138 (5):767-771. [Details]
Croinin, TO; Clyne, M; Appelmelk, BJ; Drumm, B; ; (2001) 'Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae'. Infection and Immunity, 69 (4):2708-2713. [Details]
Drumm B, Imrie C, Rowland M, Bourke B, ; (2001) 'Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?'. Pediatrics, 107 (2):373-380. [Details]
Bourke B, Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, ; (2001) 'The oral cavity in Crohn's disease'. Pediatrics, 138 (5):767-771. [DOI] [Details]
OCroinin, T., Clyne, M., Appelmelk, B. J., and Drumm, B.; (2001) 'Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae'. Infection and Immunity, 69 :2708-2713. [Details]
Howes, N., Rutherford, S., ODonnell, M., Imrie, C., and Drumm, B.; (2001) 'A New Polymorphism for the R122H Mutation in Hereditary Pancreatitis'. Gut, 48 :247-250. [Details]
Oral Crohns Disease The oral Cavity in Crohns Pittock, S., Drumm, B., Fleming, P., McDermott, M., Imrie, C., and Bourke, B. ; (2001) 'Oral Crohns Disease The oral Cavity in Crohns disease'. Journal of Paediatrics, . [Details]
Rowland, M., and Drumm, B.; (2001) 'Helicobacter pylori and sudden infant death'. Lancet, :327-357. [Details]
OCroinin, T., Clyne, M., Appelmelk, B. J., and Drumm, B.; (2001) 'Antigastric Autoantibodies in Ferrets Naturally Infected with Helicobacter mustelae'. Infection and Immunity, 69 :2708-2713. [Details]
Pittock S, Drumm B, Fleming P, McDermott M, Imrie I, Flint, S, Bourke B. ; (2001) 'The oral cavity in Crohn disease'. J Pediatr, (138):767-771. [Details]
O Croinin T, Clyne M, Appelmelk B, Claeys D and Drumm B; (2001) 'Presence of Antigastric Autoantibodies in Ferrets Naturally Infected with Helicobacter mustelae'. INFECTION AND IMMUNITY, 69 :2708-2713. [Details]
Pittock, S,Drumm, B,Fleming, P,McDermott, M,Imrie, C,Flint, S,Bourke, B; (2001) 'The oral cavity Crohn's disease'. Pediatrics, 138 :767-771. [Details]
Imrie, C,Rowland, M,Bourke, B,Drumm, B; (2001) 'Limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants'. Pediatrics, 139 :734-737. [Details]
Croinin, TO; Clyne, M; Appelmelk, BJ; Drumm, B; ; (2001) 'Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae'. Infection and Immunity, 69 (4):2708-2713. [Details]
Howes, N,Greenhalf, W,Rutherford, S,O'Donnell, M,Mountford, R,Ellis, I,Whitcomb, D,Imrie, C,Drumm, B,Neoptolemos, JP; (2001) 'A new polymorphism for the R122H mutation in hereditary pancreatitis'. Gut, 48 :247-250. [Details]
Croinin, TO,Clyne, M,Appelmelk, BJ,Drumm, B; (2001) 'Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae'. Infection and Immunity, 69 :2708-2713. [Details]
Howes, N; Greenhalf, W; Rutherford, S; O'Donnell, M; Mountford, R; Ellis, I; Whitcomb, D; Imrie, C; Drumm, B; Neoptolemos, JP; ; (2001) 'A new polymorphism for the R122H mutation in hereditary pancreatitis'. Gut, 48 (2):247-250. [Details]
Imrie, C; Rowland, M; Bourke, B; Drumm, B; ; (2001) 'Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?'. Pediatrics, 107 (2):373-380. [Details]
Drumm B, Bourke B, ; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Archives of Disease in Childhood, 86 (2):71-72. [Details]
Bourke, B,Drumm, B; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Childhood, 86 :71-72. [Details]
Sharif, F,McDermott, M,Dillon, M,Drumm, B,Rowland, M,Imrie, C,Kelleher, S,Harty, S,Bourke, B; (2002) 'Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis'. American Journal of Gastroenterology, 97 :1415-1420. [DOI] [Details]
Sharif, F; McDermott, M; Dillon, M; Drumm, B; Rowland, M; Imrie, C; Kelleher, S; Harty, S; Bourke, B; ; (2002) 'Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis'. American Journal of Gastroenterology, 97 (6):1415-1420. [Details]
Sharif F, McDermott M, Dillon M, Rowland M, Kelleher S, Drumm B, Bourke B. ; (2002) 'Focally enhanced gastritis in Crohn disease and ulcerative colitis'. American Journal of Gastroenterology, 97 :1415-1420. [Details]
Bourke, B; Drumm, B; ; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Archives of Disease in Childhood, 86 (2):71-72. [Details]
Crushell, E,Rowland, M,Doherty, M,Gormally, S,Harty, S,Bourke, B,Drumm, B; (2003) 'Importance of parental conceptual model of illness in severe recurrent abdominal pain'. Pediatrics, 112 :1368-1372. [Details]
Clyne, M; Dillon, P; Daly, S; O'Kennedy, R; May, FEB; Westley, BR; Drumm, B; ; (2004) 'Helicobacter pylori interacts with the human single-domain trefoil protein TFF1'. Proceedings of the National Academy of Sciences of the United States of America, 101 (19):7409-7414. [Details]
Clyne M, Dillon P, Daly S, O'Kennedy R, May FE, Westley BR, Drumm B.; (2004) 'Helicobacter pylori interacts with the human single-domain trefoil protein TFF1'. Proceedings of the National Academy of Sciences of the, 101 (19):7409-7414. [Details]
Corbett K, Kelleher S, Rowland M, Daly L, Drumm B, Canny G, Greally P, Hayes R, Bourke B.; (2004) 'Cystic fibrosis-associated liver disease: A population-based study'. Journal of Paediatrics, 145 :327-332. [Details]
Clyne, M,Drumm, B; (2004) 'Helicobacter pylori infection of human and murine primary gastric cells'. Infection and Immunity, 72 :5464-5469. [DOI] [Details]
Clyne, M,Dillon, P,Daly, S,O'Kennedy, R,May, FEB,Westley, BR,Drumm, B; (2004) 'Helicobacter pylori interacts with the human single-domain trefoil protein TFF1'. Proceedings of the National Academy of Sciences of the United States of America, 101 :7409-7414. [DOI] [Details]
Clyne, M; Drumm, B; ; (2004) 'Helicobacter pylori infection of human and murine primary gastric cells'. Infection and Immunity, 72 (9):5464-5469. [Details]
Harty S, Fleming P, Rowland M, Crushell E, McDermott M, Drumm B, Bourke B. ; (2005) 'A prospective study of the oral manifestations of Crohns disease'. Clinical Gastroenterology and Hepatology, 3 :886-891. [Details]
Rowland M, Bourke B, Drumm B. ; (2005) 'Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (Supp 1):S32-S33. [Details]
Rowland, M; Bourke, B; Drumm, B; ; (2005) 'Functional abdominal pain - Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (NA):32-33. [Details]
Murphy, A. M.,Drumm, B.,Brenner, C.,Lynch, S. A.; (2006) 'Diencephalic cachexia of infancy: Russell's syndrome'. Clin Dysmorphol, 15 (4):253-4. [Details]
Rowland, M,Daly, L,Vaughan, M,Higgins, A,Bourke, B,Drumm, B; (2006) 'Age-Specific incidence of Helicobacter pylori'. GASTROENTEROLOGY, 130 (NA):65-72. [DOI] [Details]
Dolan, B., Drumm, B., Clyne, M., ; (2007) 'The interaction of Helicobacter pylori with a mucous secreting cell line'. Zoonoses and Public Health, 54 :95-95. [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2007) 'Outcome for children with cyclical vomiting syndrome'. Archives of Disease in Childhood, 92 (11):1001-1004. [DOI] [Details]
Oderda, G,Shcherbakov, P,Bontems, P,Urruzuno, P,Romano, C,Gottrand, F,Gomez, MJM,Ravelli, A,Gandullia, P,Roma, E,Cadranel, S,De Giacomo, C,Canani, RB,Rutigliano, V,Pehlivanoglu, E,Kalach, N,Roggero, P,Celinska-Cedro, D,Drumm, B,Casswall, T,Ashorn, M,Arvanitakis, SN,PERTH Grp; (2007) 'Results from the Pediatric European Register for Treatment of Helicobacter pylori (PERTH)'. Helicobacter, 12 :150-156. [Details]
Reeves, E. P., Leonard, P., Hearty, S., O'Kennedy, R., May, F. E. B., Westley, B. R., Drumm, B., Clyne, M., ; (2007) 'Rough-form lipopolysaccharide of Helicobacter pylori promotes adhesion to trefoil protein TFF1 - a pH regulated interaction'. Zoonoses and Public Health, 54 :8-8. [Details]
Oderda, G; Shcherbakov, P; Bontems, P; Urruzuno, P; Romano, C; Gottrand, F; Gomez, MJM; Ravelli, A; Gandullia, P; Roma, E; Cadranel, S; De Giacomo, C; Canani, RB; Rutigliano, V; Pehlivanoglu, E; Kalach, N; Roggero, P; Celinska-Cedro, D; Drumm, B; Casswall, T; Ashorn, M; Arvanitakis, SN; PERTH Grp; ; (2007) 'Results from the Pediatric European Register for Treatment of Helicobacter pylori (PERTH)'. Helicobacter, 12 (2):150-156. [Details]
Reeves, EP,Ali, T,Leonard, P,Hearty, S,O'Kennedy, R,May, FEB,Westley, BR,Josenhans, C,Rust, M,Suerbaum, S,Smith, A,Drumm, B,Clyne, M; (2008) 'Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner'. Gastroenterology, 135 :2043-2054. [DOI] [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2008) 'The incidence of cyclic vomiting syndrome in children: population-based study'. American Journal of Gastroenterology, 103 (4):991-91. [DOI] [Details]
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B (2011) 'Disease outcome for children who present with oral manifestations of Crohn's disease'. European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 12 (3):167-169. [Details]
Drumm B, Rowland M; (2011) 'Why is Helicobacter pylori disappearing? More questions than answers'. Jornal de pediatria, 87 (5):369-370. [DOI] [Details]

Other Journals

Harty, S., Fleming, P., Rowland, M., Crushell, E., McDermott, M., Drumm, B., Bourke, B.; (2005) 'A prospective study of the oral manifestations of Crohn's disease' Clin Gastroenterol Hepatol . [Details]
Harty, S., Fleming, P., Rowland, M., Crushell, E., McDermott, M., Drumm, B., Bourke, B.; (2005) 'A prospective stidy of the oral manifestations of Crohn's disease' Clin Gastroenterol Hepatol . [Details]

Conference Publications

O Croinin T, Clyne M and Drumm B; (1997) Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae American Gastroenterology Association : Annual General Meeting [Details]
O Croinin T, Clyne M and Drumm B; (1997) Helicobacter mustelae specific antibodies cross-react with ferret gastric tissue Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori infections [Details]
Clyne M, O Croinin T and Drumm B; (1999) Adherence of Helicobacter pylori and Helicobacter mustelae to gastric cells studied using confocal microscopy American Society of Microbiology : Annual General Meeting [Details]
O Croinin T, Clyne M, Appelmelk B, Claeys D and Drumm B; (1999) Presence of anti-gastric atuoantibodies in ferrets naturally infected with Helicobacter mustelae American Society of Microbiology : Annual General Meeting [Details]
Smith, A., Clyne, M., Carrington, S.D., Drumm, B., and Reid, C.; (2007) Construction and expression of a truncated version of MUC5AC as a model system to investigate its role in pathogen'mucosal interactions Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
   

Editorial

Oderda, G,Cadranel, S,Drumm, B,Koletzko, S; (2001) Announcing the creation of the Paediatric European Register for Treatment of Helicobacter pylori (PERTH). Editorial [Details]
Rowland, M,Drumm, B; (2001) Helicobacter pylori and sudden-infant-death syndrome. Editorial [Details]
Drumm, B; (2001) The dangers of consensus. Editorial [Details]
Drumm, B,Rowland, M; (2003) The epidemiology of Helicobacter pylori: Where to from here?. Editorial [Details]
                                                                                   

Research

Research Interests

RESEARCH.

 

 

1) The pathogenesis of Helicobacter pylori infection.

   Over the past 20 years my colleague Dr Marguerite Clyne and I have worked on characterising the mechanism by which H pylori attaches to the gastric mucosa. We developed unique in vitro models of infection to characterise this interaction. This work has resulted in several publications in the world's leading journal in this area ¿Gastroenterology¿ and in journals such as Proceedings of the National Academy of Sciences.

 

2) The epidemiology of Helicobacter pylori.

Within our group we have developed one of the world's leading units studying the acquisition and transmission of this infection. The epidemiology of H. pylori is of great importance as it explains the remarkable decrease in the prevalence of two of the world's most important diseases in the 20th century peptic ulcer disease and gastric cancer. We have conducted the only prospective study on the acquisition of H pylori infection. Our comprehensively characterised population from all across Ireland provides the basis for continuing studies in this important area. Our studies have been published on a number of occasions in The New England Journal of Medicine and in Gastroenterology. Our group have been invited to provide commentaries on the epidemiology of H. pylori on  two occasions for The Lancet.

 

3) Paediatric gastrointestinal and liver disease.

Because of the large population attending our national centre for Paediatric Gastrointestinal diseases we have contributed extensively to the literature in relation to this specialty. These studies have varied from the management of children with stress-related gastrointestinal symptoms to defining the optimal method for carrying out colonoscopy in children. Members of our group have been to the forefront internationally in characterising the oral manifestations of Crohn's disease and the natural history of this condition.

We were the first group in the world to report on the use of granulocyte colony stimulating factor as a novel approach to treating Crohn's disease. There are now groups all across the world studying the use of stimulating factors in treating inflammatory bowel disease.

 

4) Following my return to academic work, having spent 5 years as CEO of the Irish health service, I am developing programs for healthcare professionals to become skilled in the delivery of care for patients rather than simply focusing on treatment and outcome.  Clinicians can become leaders in changing the emphasis in healthcare from simply providing technical assistance to a holistic approach to the needs of patients which include care as well as treatment. Research in this area will be of significant importance over the next 20 years.

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : The role of the oxidative pertose phosphate pathway in helicobacter induced apoptosis in primary culture of gastric cells from a ferret
Start Date / End Date : 01-JUL-01 / 04-AUG-01
Sponsor : The Wellcome Trust (WT)
Title : No Project title to migrate.
Start Date / End Date : 01-OCT-97 / 30-SEP-02