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Researchers at UCD

researcher

Colm O'Brien

Professor of Ophthalmology

School Of Medicine & Medical Science
Mater Hospital
Eccles Street
Dublin 7

Tel: +353 1 716
Email: cobrien@mater.ie

Professional

           

Committees

Committee : National Council for the Blind of Ireland
Committee : Fighting Blindness Ireland, Scientific Advisory Board
Committee : Drug Safety Committee, Mater Misericordiae University Hospital
Committee : UK & Eire Glaucoma Society Committee
           

Other Activities

Orbis Volunteer, China 2006

Publications

 

Book Chapters

S Wilson, S J A Rankin, C O'Brien, Y Delaney; (2007) 'Diagnosis of glaucoma through examination of the optic nerve head' In: D F Edgar, A Rudnicka (eds). Glaucoma Co-Management. London: Butterworth-Heinemann Limited. [Details]
C O'Brien, E Henry; (1999) 'Anti-Glaucoma Drugs' In: D Easty, J Sparrow (eds). Oxford Textbook of Ophthalmology. Oxford: Oxford University Press. [Details]
C O'Brien; (1999) 'Management of Glaucoma' In: D Easty, J Sparrow (eds). Oxford Textbook of Ophthalmology. Oxford: Oxford University Press. [Details]
C O'Brien, A Harris; (1999) 'Optic Nerve Blood Flow Measurement' In: M Yanoff, J Duker (eds). Ophthalmology. London: C V Mosby. [Details]
C O'Brien, J Diamond; (1999) 'Primary Open Angle Glaucoma' In: Clinical Evidence. London: BMJ Publishing Group. [Details]
 

Peer Reviewed Journals

O'Connor, R,Cryan, LM,Wynne, K,de Stefani, A,Fitzgerald, D,O'Brien, C,Cagney, G; (2010) 'Proteomics Strategy for Identifying Candidate Bioactive Proteins in Complex Mixtures: Application to the Platelet Releasate'. Journal Of Biomedicine And Biotechnology, . [DOI] [Details]
Dervan, EW,Chen, H,Ho, SL,Brummel, N,Schmid, J,Toomey, D,Haralambova, M,Gould, E,Wallace, DM,Prehn, JHM,O'Brien, CJ,Murphy, D; (2010) 'Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma'. Investigative Ophthalmology &Amp; Visual Science, 51 :2968-2975. [DOI] [Details]
Cryan, LM,Fitzgerald, DJ,O'Brien, C; (2009) 'Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclooxygenase'. Prostaglandins Leukotrienes and Essential Fatty Acids, 81 :401-409. [DOI] [Details]
Kirwan, RP,Wordinger, RJ,Clark, AF,O'Brien, CJ; (2009) 'Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells'. Molecular Vision, 15 :76-88. [Details]
Irnaten, M,Barry, RC,Quill, B,Clark, AF,Harvey, BJP,O'Brien, CJ; (2009) 'Activation of Stretch-Activated Channels and Maxi-K+ Channels by Membrane Stress of Human Lamina Cribrosa Cells'. Investigative Ophthalmology &Amp; Visual Science, 50 :194-202. [DOI] [Details]
Cotter TG, O'Connor JC, Wallace DM, O'Brien CJ, ; (2008) 'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 49 (10):4237-4244. [DOI] [Details]
O'Brien C, Kane R, Godson C, ; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
O'Brien C et al; (2008) 'Evaluation of LOX1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma'. Molecular Vision, 17 (14):533-541. [Details]
Kane, R,Godson, C,O'Brien, C; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
O'Driscoll, C,O'Connor, J,O'Brien, CJ,Cotter, TG; (2008) 'Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo'. Neurochemistry, 105 :524-536. [DOI] [Details]
O'Brien C, Irnaten M, Barry RC, Quill B, Clark AF, Harvey B, ; (2008) 'Membrane Stress Of Human Lamina Cribrosa Cells Activates Stretch Activated Channels and Maxi K+ Channels'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, . [DOI] [Details]
O'Brien C et al; (2008) 'Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo'. Journal of Neurochemistry, 105 (2):524-536. [Details]
Jones JF, Healy CF, O'Herlihy C, O'Brien C, O'Connell PR, ; (2008) 'Experimental models of neuropathic fecal incontinence: an animal model of childbirth injury to the pudendal nerve and external anal sphincter'. Diseases of the Colon &Amp; Rectum, 11 (NA):1619-161. [DOI] [Details]
Cryan, LM,Paraoan, L,Hiscott, P,Damato, BE,Grierson, I,Gray, D,Farrell, M,Doherty, GA,Fitzgerald, DJ,O'Brien, C; (2008) 'Expression of COX-2 and prognostic outcome in uveal melanoma'. Current Eye Research, 33 (NA):177-184. [DOI] [Details]
Lee H, O'Meara S, O'Brien C, Kane R.; (2007) 'The role of gremlin, a BMP antagonist, and epithelial to mesenchymal transition in proliferative vitreoretinopathy'. Investigative Ophtalmology and Visual Science, 48 (9):4291-4299. [Details]
Horgan, N.,Kirwan, R. P.,O'Brien, C. J.; (2007) 'Choroidal detachment associated with latanoprost use in the fellow eye'. Ann Pharmacother, 41 (1):161-2. [Details]
Cotter TG, McKernan DP, Guerin MB, O'Brien CJ, ; (2007) 'A key role for calpains in retinal ganglion cell death'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 48 (12):5420-5430. [DOI] [Details]
Cahill PA, Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O'Brien C, ; (2007) 'High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway'. Journal Molecular Cell Cardiology, 42 (3):609-619. [DOI] [Details]
O'Brien, C., Polakova, M., Pitt, N., Tosin, M., Murphy, P.V., ; (2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'. CHEMISTRY-A EUROPEAN JOURNAL, 13 (3):902-909. [Details]
Lee, H,O'Meara, SJ,O'Brien, C,Kane, R; (2007) 'The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy'. Investigative Ophthalmology &Amp; Visual Science, 48 :4291-4299. [DOI] [Details]
Mahony R, O'Brien C, Kinsley B, Firth R, Coffey M, O'Connell R, O'Herlihy C; (2007) 'Antepartum pudendal neuropathy and the effect of vaginal delivery in women with type 1 diabetes mellitus'. International Journal of Diabetes and Metabolism, . [Details]
Cahill PA, Connell P, Walshe T, Ferguson G, Gao W, O'Brien C, ; (2007) 'Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells'. Endothelium : journal of endothelial cell research, 14 (1):17-24. [DOI] [Details]
Delaney, Y; Walshe, TE; O'Brien, C; ; (2006) 'Vasospasm in glaucoma: Clinical and laboratory aspects'. Optometry and Vision Science, 83 (7):406-414. [Details]
Guerin, MB; McKernan, DP; O'Brien, CJ; Cotter, TG; ; (2006) 'Retinal ganglion cells: dying to survive'. International Journal of Developmental Biology, 50 (8):665-674. [Details]
Henry, E.,Newby, D. E.,Webb, D. J.,Hadoke, P. W.,O'Brien, C. J.; (2006) 'Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma'. Invest Ophthalmol Vis Sci, 47 (6):2528-32. [Details]
Kelliher, C,Kenny, D,O'Brien, C; (2006) 'Trends in blind registration in the adult population of the Republic of Ireland 1996-2003'. British Journal of Ophthalmology, 90 :367-371. [DOI] [Details]
Cryan, L,Pidgeon, G,Fitzgerald, D,O'Brien, C; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. Molecular Vision, 12 :405-414. [Details]
McKernan, DP,Caplis, C,Donovan, M,O'Brien, CJ,Cotter, TG; (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology &Amp; Visual Science, 47 :807-814. [DOI] [Details]
Greene BR, de Chazal P, Boylan G, Reilly RB, O'Brien C, Connolly S. ; (2006) 'Heart and respiration rate changes in the neonate during electroencephalographic seizure'. Medical and Biological Engineering and Computing, 44 (1-2):27-34. [Details]
Cryan, L.M., Pidgeon, G.P., Fitzgerald, D.J., O'Brien, C.J.; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. MOLECULAR VISION, . [Details]
Cryan, L. M., Pidgeon, G. P., Fitzgerald, D. J., O'Brien, C. J.; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. Molecular Vision, 12 :405-14. [Details]
Cryan, L, Pidgeon, G, Fitzgerald, D, O'Brien, C, ; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. Molecular Vision, 12 (46-47):405-414. [Details]
Knox, F. A.,Barry, M.,McGowan, B.,O'Brien, C.; (2006) 'The rising cost of glaucoma drugs in Ireland 1996-2003'. Br J Ophthalmol, 90 (2):162-5. [Details]
Kelliher, C; Kenny, D; O'Brien, C; ; (2006) 'Trends in blind registration in the adult population of the Republic of Ireland 1996-2003'. British Journal of Ophthalmology, 90 (3):367-371. [Details]
McKernan, DP; Caplis, C; Donovan, M; O'Brien, CJ; Cotter, TG; ; (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology &Amp; Visual Science, 47 (3):807-814. [Details]
Ho, SL; Dogar, GF; Wang, J; Crean, J; Wu, QD; Oliver, N; Weitz, S; Murray, A; Cleary, PE; O'Brien, C; ; (2005) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. British Journal of Ophthalmology, 89 (2):169-173. [Details]
Kirwan, RP; Leonard, MO; Murphy, M; Clark, AF; O'Brien, CJ; ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
Cleary, C,Buckley, CH,Henry, E,McLoughlin, P,O'Brien, C,Hadoke, PWF; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 :223-228. [DOI] [Details]
Ho, SL,Dogar, GF,Wang, J,Crean, J,Wu, QD,Oliver, N,Weitz, S,Murray, A,Cleary, PE,O'Brien, C; (2005) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. British Journal of Ophthalmology, 89 :169-173. [DOI] [Details]
Cleary, C; Buckley, CH; Henry, E; McLoughlin, P; O'Brien, C; Hadoke, PWF; ; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 (2):223-228. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology &Amp; Visual Science, 46 (NA). [Details]
Kirwan, RP,Fenerty, CH,Crean, J,Wordinger, RJ,Clark, AF,O'Brien, CJ; (2005) 'Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro'. Molecular Vision, 11 :798-810. [Details]
Kirwan, RP,Leonard, MO,Murphy, M,Clark, AF,O'Brien, CJ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 :309-324. [DOI] [Details]
Kane, R,Stevenson, L,Godson, C,Stitt, AW,O'Brien, C; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 :1638-1642. [DOI] [Details]
Browne, JG, Kane, R, Godson, C, Cotter, TG, O'Brien, CJ, ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology &Amp; Visual Science, 46 (NA). [Details]
Kirwan, RP; Fenerty, CH; Crean, J; Wordinger, RJ; Clark, AF; O'Brien, CJ; ; (2005) 'Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro'. Molecular Vision, 11 (94-96):798-810. [Details]
Ho, SL; Dogar, GF; Wang, J; Crean, J; Wu, QD; Oliver, N; Weitz, S; Murray, A; Cleary, PE; O'Brien, C; ; (2005) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. British Journal of Ophthalmology, 89 (2):169-173. [Details]
Kirwan, RP; Leonard, MO; Murphy, M; Clark, AF; O'Brien, CJ; ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
Kirwan, RP, Leonard, MO, Murphy, M, Clark, AF, O'Brien, CJ, ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
O'Brien CJ, Long VW, ; (2005) 'Trends in ophthalmic surgery in Ireland'. Irish Journal of Medical Science, 174 (2):36-39. [Details]
Cahill PA, Walshe TE, Ferguson G, Connell P, O'Brien C, ; (2005) 'Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculature'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 46 (1):375-382. [DOI] [Details]
Cleary, C; Buckley, CH; Henry, E; McLoughlin, P; O'Brien, C; Hadoke, PWF; ; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 (2):223-228. [Details]
Kirwan, RP; Fenerty, CH; Crean, J; Wordinger, RJ; Clark, AF; O'Brien, CJ; ; (2005) 'Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro'. Molecular Vision, 11 (94-96):798-810. [Details]
Kane, R; Stevenson, L; Godson, C; Stitt, AW; O'Brien, C; ; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 (12):1638-1642. [Details]
Kirwan, RP; Crean, JK; Fenerty, CH; Clark, AF; O'Brien, CJ; ; (2004) 'Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta 1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head'. Journal of Glaucoma, 13 (4):327-334. [Details]
Azuara-Blanco A, Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O'Brien CJ, ; (2004) 'Three dimensional analysis of the lamina cribrosa in glaucoma'. British Journal of Ophthalmology, 88 (10):1299-1304. [DOI] [Details]
Kirwan, RP; Crean, JK; Fenerty, CH; Clark, AF; O'Brien, CJ; ; (2004) 'Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta 1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head'. Journal of Glaucoma, 13 (4):327-334. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2004) 'Mechanism of pericyte apoptosis following glucose exposure'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):88-88. [Details]
Kirwan, C; Howell, K; O'Brien, CO; McLoughlin, P; ; (2004) 'The role of nitric oxide in angiogenesisin the globally hypoxic retina'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):739-739. [Details]
Shortt, AJ,Howell, K,O'Brien, C,McLoughlin, P; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 :349-356. [Details]
Kirwan, RP; Crean, JK; Clark, A; O'Brien, CJ; ; (2004) 'The effect of transforming growth factor beta-1 (TGF-beta 1) on gene expression profiles in lamina cribrosa cells from the human optic nerve head'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):408-408. [Details]
Shortt, AJ; Howell, K; O'Brien, C; McLoughlin, P; ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [Details]
Kirwan, RP,Crean, JK,Fenerty, CH,Clark, AF,O'Brien, CJ; (2004) 'Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta 1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head'. Journal of Glaucoma, 13 :327-334. [Details]
Shouldice, RB,O'Brien, LM,O'Brien, C,de Chazal, P,Gozal, D,Heneghan, C; (2004) 'Detection of obstructive sleep apnea in pediatric subjects using surface lead electrocardiogram features'. Sleep, 27 (NA):784-792. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
Eogan, M; O'Brien, C; Carolan, D; Fynes, M; O'Herlihy, C; ; (2004) 'Median and ulnar nerve conduction in pregnancy'. International Journal of Gynecology &Amp; Obstetrics, 87 (3):233-236. [Details]
Cryan, LM; Pidgeon, GP; Fitzgerald, DJ; O' Brien, C; ; (2004) 'COX-2 has a protective role in a mouse model of ischaemic retinopathy'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):354-354. [Details]
Crean JK, Kirwan R, Finerty C and OBrien C; (2004) 'Matrix metalloproteinase-2/type IV collagenase secretion in human lamina cribrosa cells is modulated by cyclical mechanical stretch and transforming growth factor-b1'. Journal of Glaucoma In Press . [Details]
McLoughlin P, Shortt AJ, Howell K, O'Brien C, ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [DOI] [Details]
Shortt, AJ, Howell, K, O'Brien, C, McLoughlin, P, ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [DOI] [Details]
O'Brien C, Nelson P, Aspinall P, Papasouliotis O, Worton B, ; (2003) 'Quality of life in glaucoma and its relationship with visual function'. Journal of Glaucoma, 12 (2):139-150. [Details]
Andrew R, Stokes J, Walker BR, Campbell JC, Seckl JR, O'Brien C, ; (2003) 'Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 44 (12):5163-5167. [Details]
O'Brien C, Kerr J, Nelson P, ; (2003) 'Pulsatile ocular blood flow in primary open-angle glaucoma and ocular hypertension'. American journal of ophthalmology, 136 (6):1106-1113. [Details]
Kirwan, RP; Crean, JK; Fenerty, C; Clark, AF; O'Brien, CJ; ; (2003) 'Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):295-295. [Details]
Kane, R; Godson, C; Brady, HR; O'Brien, C; ; (2003) 'Differential gene expression in human retinal pericytes in response to glucose and hypoxia'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):395-395. [Details]
Ho, S; Crean, J; Oliver, N; Klaus, S; O'Brien, C; ; (2003) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):519-519. [Details]
Chang, B; Madden, S; Doran, P; Kane, R; O'Brien, C; ; (2003) 'In silico gene identification of eye specific genes'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):81-81. [Details]
Cryan, LM; Fitzgerald, DJ; O'Brien, C; ; (2003) 'Isoform specific disruption of the cyclooxygenase genes in oxygen-induced retinopathy'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):77-77. [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) 'Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery'. Eye, 17 (5):628-636. [DOI] [Details]
Buckley, C; Hadoke, PWF; Henry, E; O'Brien, C; ; (2002) 'Systemic vascular endothelial cell dysfunction in normal pressure glaucoma'. British Journal of Ophthalmology, 86 (2):227-232. [Details]
Buckley, C,Hadoke, PWF,Henry, E,O'Brien, C; (2002) 'Systemic vascular endothelial cell dysfunction in normal pressure glaucoma'. British Journal of Ophthalmology, 86 :227-232. [Details]
O'Brien C, O'Toole L, Cahill M, ; (2001) 'Eyelid hypertrichosis associated with latanoprost is reversible'. European journal of ophthalmology, 11 (4):377-379. [Details]
Devlin, HC; Crean, J; Fenerty, C; Clark, AF; O'Brien, C; ; (2001) 'Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells'. Investigative Ophthalmology &Amp; Visual Science, 42 (4):140-140. [Details]
O Brien C, Devlin H; (2001) 'Normal Tension Glaucoma; Diagnosis and Management'. CME journal of ophthalmology, 5 (1):13-17. [Details]
O'Brien, CJ; Fenerty, CH; Crean, JKG; Clark, AF; ; (2001) 'Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes'. Investigative Ophthalmology &Amp; Visual Science, 42 (4):511-511. [Details]
O'Toole, L,Cahill, M,O'Brien, C; (2001) 'Eyelid hypertrichosis associated with Latanoprost is reversible'. European journal of ophthalmology, 11 :377-379. [Details]
O'Brien CJ, King AJ, Bolton N, Aspinall P, ; (2000) 'Measurement of peripapillary retinal nerve fiber layer volume in glaucoma'. American journal of ophthalmology, 129 (5):599-607. [Details]
Andrew R, Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, ; (2000) 'Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 41 (7):1629-1638. [Details]
O'Brien CJ, Morgan-Davies J, King AJ, Aspinall P, ; (2000) 'Measurement of a novel optic disc topographic parameter, spikiness, in glaucoma'. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 238 (8):669-676. [Details]
Nelson P, MacKinnon JR, McKillop G, O'Brien C, Swa K, Butt Z, ; (2000) 'Colour Doppler imaging of the ocular circulation in diabetic retinopathy'. Acta ophthalmologica Scandinavica, 78 (4):386-389. [Details]
O'Brien CJ, Edgar DF, Crabb DP, Rudnicka AR, Lawrenson JG, Guttridge NM, ; (1999) 'Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity'. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 237 (2):117-124. [Details]
O'Brien C, Nelson P, Aspinall P, ; (1999) 'Patients' perception of visual impairment in glaucoma: a pilot study'. British Journal of Ophthalmology, 83 (5):546-552. [Details]
O'Brien C, Henry E, Newby DE, Webb DJ, ; (1999) 'Peripheral endothelial dysfunction in normal pressure glaucoma'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 40 (8):1710-1714. [Details]
Butt Z, O'Brien C, ; (1999) 'Blood flow velocity in the peripheral circulation of glaucoma patients'. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 213 (3):150-153. [Details]
O'Brien C, ; (1998) 'Is there a role for computerised image analysis in glaucoma management?'. British Journal of Ophthalmology, 82 (1):2-3. [Details]
O'Brien C, Kerr J, Nelson P, ; (1998) 'A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension'. American journal of ophthalmology, 126 (1):42-51. [Details]
O'Brien C, ; (1998) 'Vasospasm and glaucoma'. British Journal of Ophthalmology, 82 (8):855-856. [Details]
Kelly, PAT,Buckley, CH,Ritchie, IM,O'Brien, C; (1998) 'Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat'. British Journal of Ophthalmology, 82 :1199-1202. [Details]
O'Brien CJ, Buckley CH, Hadoke PW, ; (1998) 'Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists'. British Journal of Ophthalmology, 82 (7):826-829. [Details]
O'Brien C, Kelly PA, Buckley CH, Ritchie IM, ; (1998) 'Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat'. British Journal of Ophthalmology, 82 (10):1199-1202. [Details]
Hitchings RA, Fontana L, Poinoosawmy D, Bunce CV, O'Brien C, ; (1998) 'Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects'. British Journal of Ophthalmology, 82 (7):731-736. [Details]

Other Journals

Greene, B.R., deChazal, P., Boylan, G, O'Brien, C., Reilly, R.B., Connolly, S.; (2006) 'Autonomic Changes in the Neonate during Seizure' Medical & Biological Engineering and Computing 44 (1, 2) :27-34. [Details]
O'Brien, C. and Heneghan, C. ; (2006) 'A comparison of algorithms for estimation of a respiratory signal from the surface electrocardiogram' Computers in Biology and Medicine Jun-06 :1-10. [Details]
R.B. Shouldice, L. M. O'Brien, C. O'Brien, P. de Chazal, D Gozal, C Heneghan; (2004) 'Detection of obstructive sleep apnea in pediatric subjects using surface lead electrocardiogram features' Sleep 27 :784-792. [Details]

Conference Publications

O'Brien C, Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, ; (2008) Current eye research Expression of COX-2 and prognostic outcome in uveal melanoma , pp.177-184 [DOI] [Details]
Sarfarazi M, Aragon-Martin JA, Ritch R, Liebmann J, O'Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, ; (2008) Molecular vision Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma , pp.533-541 [Details]
Cotter TG, O'Driscoll C, O'Connor J, O'Brien CJ, ; (2008) Journal of neurochemistry Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo , pp.524-536 [DOI] [Details]
Healy, C.F., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The effects of obstetric trauma on the pudendal nerve - early report on the development of an acute animal model to simulate the anatomical distortions associated with childbirth Sylvestor O'Halloran Surgical Scientific Meeting [Details]
O'Brien, C. and Heneghan, C.; (2006) Variations in ECG derived respiratory signal frequency in REM and non-REM sleep SENSATION International Conference - Monitoring Sleep and Sleepiness Basel, Switzerland, , 29-MAY-06 - 30-MAY-06 [Details]
Keane, PA, O'Brien, C, McLoughlin, P, ; (2005) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE The role of the nitric oxide precursor, L-arginine in angiogenesis involving the globally hypoxic adult retina [Details]
R. Shouldice, S. Ward, L.M. O'Brien, C. O'Brien, S. Redmond, D. Gozal, C. Heneghan; (2004) PR and PP ECG interval variation during obstructive apnea and hypopnea Proceedings of the IEEE 30th Annual Northeast Bioengineering Conference , pp.100-101 [Details]
O'Brien, CJ; Hanel, M; Dolan, V; Brady, HR; Hensey, C; ; (2003) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Expression and function of gremlin in the developing Xenopus eye , pp.127-127 [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) EYE Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery , pp.628-636 [DOI] [Details]
                                       

Presentation

Ho S, Crean J, Oliver N, Klaus S, O'Brien C.; (2003) Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Presentation [Details]
Devlin HC, Crean J, Fenerty C, Clark AF, O'Brien C.; (2001) Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells. Presentation [Details]
O'Brien CJ, Fenerty CH, Crean JKG, Clark AF; (2001) Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes. Presentation [Details]
                                               

Research

Research Interests

Clinical: Glaucoma and Diabetic Retinopathy
Laboratory: Matrix and Vascular Biology, Neuro-degeneration
Health Services Research

Current Funding:
National Council for the Blind of Ireland 2005-2007, Mechanisms in diabetic retinopathy. €305,000; C O'Brien, N Sweeney, L Cryan


Health Research Board 2004-2006, North-South Grants, Molecular mechanism of retinal pericyte apoptosis in diabetic retinopathy €240,000 C O'Brien, A Stitt, T Cotter


National Glaucoma Research; American Health Assistance Foundation $90,000 2007-2009
Modulation of lamina cribrosa matrix remodeling in POAG


Glaucoma Research Foundation, New York $37,000 2007-2008
Elucidation of mechano-transduction pathways in lamina cribrosa cells: Implications for glaucomatous cupping.


Research Projects

Sponsor : Health Research Board (HRB)
Title : Novel Anti-Connective Tissue Growth Factor Antibody Therapy in Pseudoexfoliation Glaucoma
Start Date / End Date : 01-DEC-10 / 01-DEC-13
Sponsor : Institute of Ophthalmology
Title : Intracellular Calcium Handling Defect in Glaucomatous Lamina Cribrosa Cells
Start Date / End Date : 01-OCT-08 / 30-SEP-09
   

Collaborators

Internal Collaborators

External Collaborators

A Stitt (Belfast) T Cotter (Cork) B Harvey (Dublin)
A Clark (Fort Worth, Texas)