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Researchers at UCD

researcher

Eoin O'Brien

School of Medicine and Medical Science

Tel: +353 1 716
Email: eobrien@iol.ie

Biography

QUALIFICATIONS and DEGREES:
Licentiate of The Royal College of Physicians and Surgeons of Ireland.
LRCP & SI June 1963
Membership of The Royal College of Physicians of Ireland.
MRCP (IRL) March 1971
Membership of The Royal College of Physicians of London.
MRCP (UK) April 1971
Fellowship of The Royal College of Physicians of Ireland.
FRCP (IRL) June 1975
Fellowship of The Royal College of Physicians of London.
FRCP (UK) November 1982
Doctorate of Medicine, National University of Ireland.
MD December 1983
Fellowship of the Royal College of Physicians of Edinburgh.
FRCP (Edin) November 1993
Doctorate of Science DSc (NUI) November 2006

Publications

 

Book Chapters

O'Brien E; (2009) 'Assessment of the circadian cardiovascular risk with ambulatory blood pressure measurement' In: Giuseeppe Mancia (eds). Manual of Hypertension of the ESH. London: Informa Healthcare. [Details]
 

Peer Reviewed Journals

O'Brien, E.; (2010) 'An endothelin antagonist for resistant hypertension'. Lancet, 375 (9715):636-636. [Details]
Rothwell, P. M.,Howard, S. C.,Dolan, E.,O'Brien, E.,Dobson, J. E.,Dahlof, B.,Sever, P. S.,Poulter, N. R.; (2010) 'Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension'. Lancet, 375 (9718):895-905. [Details]
O'Brien E, Atkins N, , Stergiou G, Parati G, Asmar R, Imai Y,Wang J, Mengden T, Shennan A on behalf of the Working Group on Blood Pressure Monitoring of the European Society of Hypertension; (2010) 'European Society of Hypertension Internationa Protocol for the Validation of Blood Pressure Measuring Devices in Adults. 2010 Revision'. Blood Press Monit, . [Details]
Stergiou G, Karpettas N, Atkins N, O'Brien E. European Society of Hypertension ; (2010) 'International Protocol for the validation of blood pressure monitors: A critical review of its application and rationale for revision'. Blood Press Monit, . [Details]
McGowan N, Atkins N, O'Brien E, Padfield P.; (2010) 'Computerised reporting improves the clinical use of ambulatory blood pressure measurement'. Blood Press Monit, . [Details]
Thijs L,Richart T, de Leeuw PW, Kuznetsova T,Grodzicki T, Kawecka-Jaszcz K, O'Brien E,Redón J, Birkenhäger WH, Fagard R, Staessen JA.; (2010) 'Morbidity and mortality on combination versus monotherapy: a post-hoc analysis of the Systolic Hypertension in Europe trial'. Hypertension, . [Details]
Stanton, A. V.,Dicker, P.,O'Brien, E. T.; (2009) 'Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high- and low-baseline PRA levels, respectively'. Am J Hypertens, 22 (9):954-7. [Details]
Dolan, E.,Stanton, A. V.,Thom, S.,Caulfield, M.,Atkins, N.,McInnes, G.,Collier, D.,Dicker, P.,O'Brien, E.,ASCOT Investigators; (2009) 'Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy'. Journal of Hypertension, 27 (4):876-885. Available Online [Details]
Stettler, C.,Witt, N.,Tapp, R. J.,Thom, S.,Allemann, S.,Tillin, T.,Stanton, A.,O'Brien, E.,Poulter, N.,Gallimore, J. R.,Hughes, A. D.,Chaturvedi, N.; (2009) 'Serum Amyloid A, C-Reactive Protein, and Retinal Microvascular Changes in Hypertensive Diabetic and Nondiabetic Individuals An Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy'. Diabetes Care, 32 (6):1098-1100. Available Online [Details]
Stanton AV, Dicker P, O'Brien ET; (2009) 'Aliskiren Monotherapy Results in the Greatest and the Least Blood Pressure Lowering in Patients With High- and Low-Baseline PRA Levels, Respectively'. American Journal of Hypertension, . [DOI] [Details]
Wizner, B.,Dechering, D. G.,Thijs, L.,Kuznetsova, T.,Richart, T.,Jin, Y.,Gasowski, J.,O'Brien, E.,Struijker-Boudier, H. A.,Grodzicki, T.,Staessen, J. A.; (2009) 'Conventional and 24-h ambulatory blood pressure an independent predictors of elastic arterial properties'. Blood Pressure Monitoring, 14 (1):12-19. Available Online [Details]
Thom, S.,Stettler, C.,Stanton, A.,Witt, N.,Tapp, R.,Chaturvedi, N.,Allemann, S.,Mayet, J.,Sever, P.,Poulter, N.,O'Brien, E.,Hughes, A.; (2009) 'Differential Effects of Antihypertensive Treatment on the Retinal Microcirculation An Anglo-Scandinavian Cardiac Outcomes Trial Substudy'. Hypertension, 54 (2):405-408. Available Online [Details]
Sharp ASP, Tapp RJ. Thom SA McG, Francis DP, Hughes AD, Stanton AV, Zambanini A, O'Brien E, Chaturvedi N, Lyons S, Byrd S, Poulter NR, Sever PS, Mayet J on behalf of the ASCOT Investigators; (2009) 'Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy'. European Heart Journal, . [DOI] [Details]
Williams B, Lacy PS,Cruickshank JK, Collier D, Hughes AD, Stanton A, Thom S, Thurston H, for the CAFE and ASCOT Investigators; (2009) 'Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics. Principal Results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study'. Circulation, 119 (53-61). [Details]
Manisty CH, Zambanini A, Parker KH, Davies JE, Francis DP, Mayet J, Thom SA McG, Hughes AD on behalf of the Anglo-Scandinavian Cardiac Outcome Trial Investigators; (2009) 'Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy'. Hypertension, 54 (724-730). [Details]
Poulter NR, Dobson JE, Sever PS, Dahlöf B,Wedel H, Campbell NRCon behalf of the ASCOT Investigators; (2009) 'Baseline Heart Rate, Antihypertensive Treatment, and Prevention of Cardiovascular Outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial)'. Journal of the American College of Cardiology, 54 (1154-1161). [Details]
O'BrienE; (2009) 'Ambulatory blood pressure measurement is indispensable to good clinical practice'. Hipertensión y Riesgo Vascular, . [DOI] [Details]
1. Kikuya M, Staessen JA, Ohkubo T, Thijs L, Metoki H, Asayama K, Obara T, Inoue R, Li Y, Dolan E, Hoshi H, Hashimoto J, Totsune K, Satoh H, Wang J-G, O'Brien E, Imai Y.; (2007) 'Ambulatory Arterial Stiffness Index and 24-Hour Ambulatory Pulse Pressure as Predictors of Mortality in Ohasama, Japan'. STROKE, 38 :1161-1166. [Details]
O'Brien E. ; (2007) 'Ambulatory Blood Pressure Measurement Should Be a Routine Investigation in Patients with Renal Disease'. European Renal Disease, :52-53. [Details]
O'Brien E, Barton J, Nussberger J, Mulcahy D, Jensen C, Dicker P, Stanton, A.; (2007) 'Aliskiren provides antihypertensive efficacy and suppression of plasma rennin activity in combination with a thiazide diuretic, an angiotensin converting enzyme inhibito, or an angiotensin receptor blocker'. Hypertension, 49 :276-284. [Details]
Atkins N, O'Brien E. ; (2007) 'The DABL®Educational Trust device equivalence procedure'. Blood Press Monit, 12 :245-249. [Details]
Atkins N, O'Brien E.; (2007) 'The dabl Educational Trust device equivalence procedure'. Blood Press Monit, 12 :245-249. [Details]
*; (2007) '1. 2007 Guidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)'. Hypertension, 25 :1105-1187. [Details]
Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Kuznetsova T, Torp Pedersen C, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'Brien E, Staessen JA; (2007) 'on behalf of the International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) Investigators. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study'. Lancet, 370 :1219-1229. [Details]
O'Brien E, Atkins N.; (2007) 'State-of-the-market from the dableducational.org website'. Blood Press Monit, 21 :377-379. [Details]
Dolan E, Staessen JA, O'Brien E.; (2007) 'Data from the Dublin outcome study'. Blood Press Monit, 21 :401-403. [Details]
O'Brien E.; (2008) 'Ambulatory Blood Pressure Measurement. The Case for Implementation in Primary Care'. Hypertension, 51 :1435-1441. [DOI] [Details]
Sever PS, Poulter NR, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien ET, Ostergren J on behalf of the ASCOT Investigators.; (2008) 'The Anglo-Scandinavian Cardiac Outcomes Trial: lipid lowering arm: extended observations 2 years after trial closure'. European Heart Journal, 29 :499-508. [Details]
Burr LM, Dolan E, O'Brien EW, O'Brien ET, McCormack P. ; (2008) 'The value of ambulatory blood pressure in older adults: the Dublin outcome study'. Age and Ageing, 37 :201-206. [Details]
Ryan AW, O'Brien E, Shields D, McManus R. ; (2008) 'Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample'. Atherosclerosis, 197 :465-466. [Details]
Adiyaman AA, Dechering DG, Thien T, Boggia J, Hanssen TW, Li Y, Wang J-G, O'Brien E , Staessen JA. ; (2008) 'Putting a spin on the ambulatory arterial stiffness index'. Journal of Hypertension, 26 :1266-1269. [Details]
Staessen JA, O'Brien E. ; (2008) 'Proceedings of a workshop of the European Society of Hypertension'. Blood Press Monit, :143-143. [Details]
Lia Y, Boggia J, Thijs L, Hansen TW, Kikuya M, Bjo rklund-Bodega rd K, Richart T, Ohkubo T, Kuznetsova T, Torp-Pedersen C, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'Brien E, Staessen JA, on behalf of the International Database on Ambulatory Blood Pressure Monitoring in relation to Cardiovascular Outcomes Investigators.; (2008) 'Is blood pressure during the night more predictive of cardiovascular outcome than during the day?'. Blood Press Monit, 13 :145-147. [Details]
Moore, N.,Dicker, P.,O'Brien, J. K.,Stojanovic, M.,Conroy, R. M.,Treumann, A.,O'Brien, E. T.,Fitzgerald, D.,Shields, D.,Stanton, A. V.; (2007) 'Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition'. Hypertension, 50 (2):340-7. [Details]
Thijs, L.,Hansen, T. W.,Kikuya, M.,Bjorklund-Bodegard, K.,Li, Y.,Dolan, E.,Tikhonoff, V.,Seidlerova, J.,Kuznetsova, T.,Stolarz, K.,Bianchi, M.,Richart, T.,Casiglia, E.,Malyutina, S.,Filipovsky, J.,Kawecka-Jaszcz, K.,Nikitin, Y.,Ohkubo, T.,Sandoya, E.,Wang, J.,Torp-Pedersen, C.,Lind, L.,Ibsen, H.,Imai, Y.,Staessen, J. A.,O'Brien, E.; (2007) 'The International Database of Ambulatory Blood Pressure in relation to Cardiovascular Outcome (IDACO): protocol and research perspectives'. Blood Press Monit, 12 (4):255-62. [Details]
O'Brien, E.,Barton, J.,Nussberger, J.,Mulcahy, D.,Jensen, C.,Dicker, P.,Stanton, A.; (2007) 'Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker'. Hypertension, 49 (2):276-84. [Details]
Staessen, J. A.,O'Brien, E.; (2007) 'Progress in blood pressure measurement: a workshop of the European Society of Hypertension'. Blood Press Monit, 12 (4):243-4. [Details]
Staessen, J. A.,O'Brien, E.; (2007) 'Will generic hypertension guidelines reduce the proliferation of directives?'. Heart, 93 (7):775-7. [Details]
O'Brien, E.; (2007) 'Sleepers versus nonsleepers: another twist to the dipper/nondipper concept'. Hypertension, 49 (4):769-70. [Details]

Other Journals

O'Brien E.; (2008) 'CHD on the increase again: fact or fiction?' Medicine Weekly . [Details]
O'Brien E.; (2008) 'Cardiovascular mortality' Medicine Weekly . [Details]
O'Brien E.; (2008) 'Stroke prevention' Irish Nursing 16 (3) . [Details]
O'Brien E.; (2008) 'The disgrace of Ireland's blood pressure statistics' Irish Medical Times . [Details]

Conference Publications

Li, Y; Wang, JG; Dolan, E; O'Brien, E; Hansen, TW; Ibsen, H; Kikuya, M; Imai, Y; Richart, T; Thijs, L; Staessen, JA; ; (2007) HYPERTENSION Response to arterial stiffness index is not a stiffness parameter but a ventriculo-arterial coupling factor , pp.8-9 [Details]
Li, Y; Wang, JG; Dolan, E; O'Brien, E; Thijs, L; Nawrot, T; Staessen, JA; ; (2006) HYPERTENSION Response to correlating ambulatory blood pressure measurements with arterial stiffness: A conceptual inconsistency , pp.109-109 [Details]
O'Halloran, AM; Stanton, A; O'Brien, E; Shields, DC; ; (2006) ANNALS OF HUMAN GENETICS The impact on coronary artery disease of common polymorphisms known to modulate responses to pathogens , pp.934-945 [Details]
Dolan, C; Shields, DC; Stanton, A; O'Brien, E; Lambert, DM; O'Brien, JK; Treacy, EP; ; (2005) BMC MEDICAL GENETICS Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians [Details]
                                                                                         

Research

Research Interests

I founded the Blood Pressure Unit in 1979 in the Charitable Infirmary, Jervis Street in collaboration with Professor Kevin O'Malley. From the outset the Unit concentrated on research into the pharmacology of blood pressure lowering drugs, particularly in the elderly, and on the development of blood pressure measuring techniques, especially techniques of ambulatory blood pressure measurement.

The Arterial Disease Assessment Prevention and Treatment (ADAPT) Clinic was established in collaboration with Professor David Bouchier-Hayes and Professor Desmond Fitzgerald in Beaumont Hospital 1997. The rationale for this unique clinic was based on the concept that disease of the arterial organ was a fundamental denominator in all-cardiovascular disease. The ADAPT Clinic was established to ensure that all patients with cardiovascular disease, regardless of the speciality to which they presented, would receive the most comprehensive risk factor assessment with appropriate life-style modification and evidence-based drug treatment directed at the arterial organ.

The ADAPT concept was further developed in 1999 with the establishment of the ADAPT Centre, which became the research facility of the Blood Pressure Unit. The ADAPT Centre was committed to the emerging role of translational research in bridging the void between the clinical ‘bedside' and the laboratory ‘bench'. The ADAPT Centre provided out-patient facilities and a cardiovascular laboratory equipped to perform state-of-the-art cardiovascular assessment that included echocardiography, electrocardiography with stress testing, Holter monitoring, applanation tonometry, pulse wave velocity analysis, 24-hour ambulatory blood pressure monitoring, beat-to-beat non-invasive blood pressure monitoring, 24-hour silent ischaemia monitoring, fundal photography and imaging, and carotid wall (intima-media thickness) imaging. Through its association with the Charitable Infirmary Trust Molecular Medicine Laboratories and the Clinical Research Centre in the RCSI Building at Beaumont Hospital, and with the Department of Clinical Pharmacology, the Centre for Proteomics, SURGEN, and BIOSYS at RCSI, the ADAPT Centre was able to further translational research into the biochemical and genetic markers of risk, thrombosis, and endothelial damage.
Twenty-one Annual Reports, which are listed elsewhere on this website, record the research, scientific presentations and publications, and most importantly the staff who performed the work of the Blood Pressure unit over its 27-year history. These reports give details of over 600 papers published in peer-reviewed journals together with numerous editorials, letters, books, book chapters, general and educational articles and abstracts. The reports also list the scientific and educational presentations made since 1988 in many countries around the world. The following list of papers, many of which are available as pdf files, summarise the scientific output of the Blood Pressure Unit and serve as a history of blood pressure management during this period. For convenience scientific publications pre-dating the foundation of the Blood Pressure Unit are also listed.