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Hugh Brady

Professor/Consultant In Medicine & Healthcare Strategy & President Emeritus

School of Medicine & Medical Science
Health Sciences Centre
Belfield
Dublin 4

Tel:
Email: hrb3@ucd.ie

Biography

Dr Hugh Brady is Professor/Consultant in Medicine & Healthcare Strategy in the UCD School of Medicine & President Emeritus of UCD. Dr Brady was President of University College Dublin from 2004 to 2013. 

Born in August 1959, he was educated at University College Dublin where he was awarded undergraduate degrees in Medicine (1982) and Science (1984). He was subsequently awarded PhD and MD degrees for research in renal physiology and molecular medicine respectively.

Prior to returning to UCD in 1996 as Professor of Medicine and Therapeutics, he spent nine years at Harvard University, most recently as Associate Professor of Medicine, and prior to that one year at the University of Toronto. In parallel with his academic career at Harvard, he served as Director of the Renal Division of the Brockton/West Roxbury VA Medical Center and Consultant Physician at the Brigham and Women's Hospital, Boston.

Following his appointment as Professor of Medicine at UCD, he played a key role in the development of (1) the UCD Catherine McAuley Centre, a medical education and research centre on the campus of the UCD-affiliated Mater Misericordiae University Hospital, (2) the UCD Conway Institute of Biomolecular and Biomedical Research, a centre of excellence in biomedical research, and (3) the Dublin Molecular Medicine Centre, a research partnership between UCD, Trinity College Dublin and Royal College of Surgeons in Ireland, formed with the objective of establishing Dublin as a leading international hub in biomedical research.

A nephrologist by training, Dr Brady¿s research interests include the molecular basis for inflammatory disease and the complications of diabetes. He has been the recipient of research grant support from the National Institutes of Health, Department of Veterans Affairs, Wellcome Trust, Irish Health Research Board and EU and has published over 150 clinical and research articles, reviews and book chapters in leading texts.
Dr Brady has served as a member and chairman of the Irish Health Research Board; a member of the Irish Higher Education Authority; President of the Irish Nephrological Society; and a member of a range of international committees and task forces.

He is married to Dr Yvonne O'Meara, and has three children. He has a keen interest in sports and as a student played rugby (under 19s) for UCD and squash for UCD and the Irish universities.

Publications

     

Peer Reviewed Journals

Egido J, Gallego-Delgado J, Connolly SB, Lázaro A, Sadlier D, Kieran NE, Sugrue DD, Doran P, Brady HR, Osende J, ; (2009) 'Transcriptome of hypertension-induced left ventricular hypertrophy and its regression by antihypertensive therapies'. Hypertension research : official journal of the Japanese Society of Hypertension, 5 (NA):347-357. [DOI] [Details]
Martin F, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Murphy M, Docherty NG, Griffin B, Howlin J, ; (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J AM SOC NEPHROL, 9 (NA):1672-1680. [DOI] [Details]
Conway, B. R.,Savage, D. A.,Brady, H. R.,Maxwell, A. P.; (2007) 'Association between haptoglobin gene variants and diabetic nephropathy: haptoglobin polymorphism in nephropathy susceptibility'. Nephron Exp Nephrol, 105 (3):e75-9. [Details]
Martin, R. J.,Savage, D. A.,Patterson, C. C.,Brady, H. R.,Maxwell, A. P.; (2007) 'Common polymorphisms of the PAI1 gene do not play a major role in the development of diabetic nephropathy in Type 1 diabetes'. Diabet Med, 24 (3):259-65. [Details]
Moss, A. C.,Lawlor, G.,Murray, D.,Tighe, D.,Madden, S. F.,Mulligan, A. M.,Keane, C. O.,Brady, H. R.,Doran, P. P.,MacMathuna, P.; (2006) 'ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion'. Biochem Biophys Res Commun, 345 (1):216-21. [Details]
McKnight, A. J.,Savage, D. A.,Patterson, C. C.,Brady, H. R.,Maxwell, A. P.; (2006) 'Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy'. J Hum Genet, 51 (4):383-6. [Details]
McKnight, A. J.,Maxwell, A. P.,Sawcer, S.,Compston, A.,Setakis, E.,Patterson, C. C.,Brady, H. R.,Savage, D. A.; (2006) 'A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy'. J Am Soc Nephrol, 17 (3):831-6. [Details]
Dolan, V.,Murphy, M.,Sadlier, D.,Lappin, D.,Doran, P.,Godson, C.,Martin, F.,O'Meara, Y.,Schmid, H.,Henger, A.,Kretzler, M.,Droguett, A.,Mezzano, S.,Brady, H. R.; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. Am J Kidney Dis, 45 (6):1034-9. [Details]
Sadlier, D. M.,Ouyang, X.,McMahon, B.,Mu, W.,Ohashi, R.,Rodgers, K.,Murray, D.,Nakagawa, T.,Godson, C.,Doran, P.,Brady, H. R.,Johnson, R. J.; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney Int, 68 (6):2542-61. [Details]
Leonard, M. O.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. J Immunol, 174 (4):2250-7. [Details]
Sadlier, D. M.,Connolly, S. B.,Kieran, N. E.,Roxburgh, S.,Brazil, D. P.,Kairaitis, L.,Wang, Y.,Harris, D. C.,Doran, P.,Brady, H. R.; (2004) 'Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy'. J Biol Chem, 279 (28):29670-80. [Details]
Power, R. E.,Doyle, B. T.,Higgins, D.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W.; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. J Urol, 171 (1):457-61. [Details]
Mitchell, D.,Rodgers, K.,Hanly, J.,McMahon, B.,Brady, H. R.,Martin, F.,Godson, C.; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. Am J Pathol, 164 (3):937-46. [Details]
Crean, J. K.,Furlong, F.,Finlay, D.,Mitchell, D.,Murphy, M.,Conway, B.,Brady, H. R.,Godson, C.,Martin, F.; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. Faseb J, 18 (13):1541-3. [Details]
Conway, B. R.,Maxwell, A. P.,Savage, D. A.,Patterson, C. C.,Doran, P. P.,Murphy, M.,Brady, H. R.,Fogarty, D. G.; (2004) 'Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes'. Diabetes, 53 (4):1162-5. [Details]
Conway, B. R.,Martin, R.,McKnight, A. J.,Savage, D. A.,Brady, H. R.,Maxwell, A. P.; (2004) 'Role of alpha-adducin DNA polymorphisms in the genetic predisposition to diabetic nephropathy'. Nephrol Dial Transplant, 19 (8):2019-24. [Details]
Madden, S. F.,O'Donovan, B.,Furney, S. J.,Brady, H. R.,Silvestre, G.,Doran, P. P.; (2003) 'Digital extractor: analysis of digital differential display output'. Bioinformatics, 19 (12):1594-5. [Details]
Leonard, M. O.,Cottell, D. C.,Godson, C.,Brady, H. R.,Taylor, C. T.; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. J Biol Chem, 278 (41):40296-304. [Details]
Kieran, N. E.,Doran, P. P.,Connolly, S. B.,Greenan, M. C.,Higgins, D. F.,Leonard, M.,Godson, C.,Taylor, C. T.,Henger, A.,Kretzler, M.,Burne, M. J.,Rabb, H.,Brady, H. R.; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney Int, 64 (2):480-92. [Details]
Higgins, D. F.,Lappin, D. W.,Kieran, N. E.,Anders, H. J.,Watson, R. W.,Strutz, F.,Schlondorff, D.,Haase, V. H.,Fitzpatrick, J. M.,Godson, C.,Brady, H. R.; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney Int, 64 (6):2079-91. [Details]
Goh, J.,Godson, C.,Brady, H. R.,Macmathuna, P.; (2003) 'Lipoxins: pro-resolution lipid mediators in intestinal inflammation'. Gastroenterology, 124 (4):1043-54. [Details]
Gallagher, J.,Howlin, J.,McCarthy, C.,Murphy, E. P.,Bresnihan, B.,FitzGerald, O.,Godson, C.,Brady, H. R.,Martin, F.; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Lett, 551 (1-3):8-12. [Details]
Dolan, V.,Murphy, M.,Alarcon, P.,Brady, H. R.,Hensey, C.; (2003) 'Gremlin - a putative pathogenic player in progressive renal disease'. Expert Opin Ther Targets, 7 (4):523-6. [Details]
Dolan, V.,Hensey, C.,Brady, H. R.; (2003) 'Diabetic nephropathy: renal development gone awry?'. Pediatr Nephrol, 18 (2):75-84. [Details]
Connolly, S. B.,Sadlier, D.,Kieran, N. E.,Doran, P.,Brady, H. R.; (2003) 'Transcriptome profiling and the pathogenesis of diabetic complications'. J Am Soc Nephrol, 14 (8 Suppl 3):S279-83. [Details]
Stenson, C.,Mitchell, S.,Lappin, D.,Brady, H. R.,Godson, C.; (2002) 'Biphasic regulation of leukocyte trafficking by lipoxins'. Adv Exp Med Biol, 507 :543-9. [Details]
Murphy, M.,McMahon, R.,Lappin, D. W.,Brady, H. R.; (2002) 'Gremlins: is this what renal fibrogenesis has come to?'. Exp Nephrol, 10 (4):241-4. [Details]
Mitchell, S.,Thomas, G.,Harvey, K.,Cottell, D.,Reville, K.,Berlasconi, G.,Petasis, N. A.,Erwig, L.,Rees, A. J.,Savill, J.,Brady, H. R.,Godson, C.; (2002) 'Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo'. J Am Soc Nephrol, 13 (10):2497-507. [Details]
McMahon, B.,Mitchell, D.,Shattock, R.,Martin, F.,Brady, H. R.,Godson, C.; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. Faseb J, 16 (13):1817-9. [Details]
Maderna, P.,Cottell, D. C.,Berlasconi, G.,Petasis, N. A.,Brady, H. R.,Godson, C.; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases'. Am J Pathol, 160 (6):2275-83. [Details]
Leonard, M. O.,Hannan, K.,Burne, M. J.,Lappin, D. W.,Doran, P.,Coleman, P.,Stenson, C.,Taylor, C. T.,Daniels, F.,Godson, C.,Petasis, N. A.,Rabb, H.,Brady, H. R.; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. J Am Soc Nephrol, 13 (6):1657-62. [Details]
Lappin, D. W.,McMahon, R.,Murphy, M.,Brady, H. R.; (2002) 'Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy'. Nephrol Dial Transplant, 17 Suppl 9 :65-7. [Details]
Lappin, D. W.,Doran, P.,Godson, C.,Brady, H. R.; (2002) 'Gene responses to hyperglycaemia'. Exp Nephrol, 10 (2):120-9. [Details]
Jones, D.,Biswas, S. K.,Power, D. A.,Cannon, S.,Brady, H. R.,Grimes, H.,Mulkerrin, E. C.; (2002) 'Posture-related tachycardia in older patients with hyponatremia'. Arch Gerontol Geriatr, 34 (2):145-54. [Details]
Hensey, C.,Dolan, V.,Brady, H. R.; (2002) 'The Xenopus pronephros as a model system for the study of kidney development and pathophysiology'. Nephrol Dial Transplant, 17 Suppl 9 :73-4. [Details]
Hegarty, N. J.,Watson, R. W.,Young, L. S.,O'Neill, A. J.,Brady, H. R.,Fitzpatrick, J. M.; (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney Int, 62 (1):70-7. [Details]
Crean, J. K.,Finlay, D.,Murphy, M.,Moss, C.,Godson, C.,Martin, F.,Brady, H. R.; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. J Biol Chem, 277 (46):44187-94. [Details]
Clarkson, M. R.,Murphy, M.,Gupta, S.,Lambe, T.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R.; (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. J Biol Chem, 277 (12):9707-12. [Details]
McMahon, B.,Mitchell, S.,Brady, H. R.,Godson, C.; (2001) 'Lipoxins: revelations on resolution'. Trends Pharmacol Sci, 22 (8):391-5. [Details]
Goh, J.,Baird, A. W.,O'Keane, C.,Watson, R. W.,Cottell, D.,Bernasconi, G.,Petasis, N. A.,Godson, C.,Brady, H. R.,MacMathuna, P.; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J Immunol, 167 (5):2772-80. [Details]
Crean, J. K.,Lappin, D.,Godson, C.,Brady, H. R.; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opin Ther Targets, 5 (4):519-530. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, P. K.,Watson, C. L.,Wolohan, L.,Brady, H. R.,O'Keane, C.,Fitzpatrick, J. M.; (2001) 'Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 (9):2297-308. [Details]
O'Neill, S.,O'Neill, A. J.,Conroy, E.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W.; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. J Leukoc Biol, 68 (1):15-20. [Details]
McMahon, R.,Murphy, M.,Clarkson, M.,Taal, M.,Mackenzie, H. S.,Godson, C.,Martin, F.,Brady, H. R.; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1'. J Biol Chem, 275 (14):9901-4. [Details]
McMahon, B.,Stenson, C.,McPhillips, F.,Fanning, A.,Brady, H. R.,Godson, C.; (2000) 'Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors'. J Biol Chem, 275 (36):27566-75. [Details]
Maderna, P.,Godson, C.,Hannify, G.,Murphy, M.,Brady, H. R.; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. Am J Physiol Cell Physiol, 279 (4):C945-53. [Details]
Lappin, D. W.,Hensey, C.,McMahon, R.,Godson, C.,Brady, H. R.; (2000) 'Gremlins, glomeruli and diabetic nephropathy'. Curr Opin Nephrol Hypertens, 9 (5):469-72. [Details]
Lappin, D. W.,Brady, H. R.; (2000) 'Light from DARCness'. Kidney Int, 58 (4):1816-7. [Details]
Gupta, S.,Clarkson, M. R.,Duggan, J.,Brady, H. R.; (2000) 'Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis'. Kidney Int, 58 (4):1389-99. [Details]
Godson, C.,Mitchell, S.,Harvey, K.,Petasis, N. A.,Hogg, N.,Brady, H. R.; (2000) 'Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages'. J Immunol, 164 (4):1663-7. [Details]
Godson, C.,Brady, H. R.; (2000) 'Lipoxins: novel anti-inflammatory therapeutics?'. Curr Opin Investig Drugs, 1 (3):380-5. [Details]
Diamond, P.,Doran, P.,Brady, H. R.,McGinty, A.; (2000) 'Suppressors of cytokine signalling (SOCS): putative modulators of cytokine bioactivity in health and disease'. J Nephrol, 13 (1):9-14. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, N. J.,O'Neill, A.,Gibbons, N.,Brady, H. R.,Fitzpatrick, J. M.; (2000) 'Thiol-mediated apoptosis in prostate carcinoma cells'. Cancer, 88 (9):2092-104. [Details]
Brannigan, A. E.,O'Connell, P. R.,Hurley, H.,O'Neill, A.,Brady, H. R.,Fitzpatrick, J. M.,Watson, R. W.; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-6. [Details]
Watson, R. W.,O'Neill, A.,Brannigan, A. E.,Coffey, R.,Marshall, J. C.,Brady, H. R.,Fitzpatrick, J. M.; (1999) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent'. FEBS Lett, 453 (1-2):67-71. [Details]
Power, D. A.,Duggan, J.,Brady, H. R.; (1999) 'Renal-dose (low-dose) dopamine for the treatment of sepsis-related and other forms of acute renal failure: ineffective and probably dangerous'. Clin Exp Pharmacol Physiol Suppl, 26 :S23-8. [Details]
Murphy, M.,Godson, C.,Cannon, S.,Kato, S.,Mackenzie, H. S.,Martin, F.,Brady, H. R.; (1999) 'Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. J Biol Chem, 274 (9):5830-4. [Details]
McGinty, A.,Clarkson, M.,Brady, H. R.; (1999) 'The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal disease'. Nephrol Dial Transplant, 14 Suppl 1 :27-9. [Details]
Maderna, P.,Coleman, P.,Godson, C.,O'Meara, Y. M.,Brady, H. R.; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. J Am Soc Nephrol, 10 (11):2403-6. [Details]
Diamond, P.,McGinty, A.,Sugrue, D.,Brady, H. R.,Godson, C.; (1999) 'Regulation of leukocyte trafficking by lipoxins'. Clin Chem Lab Med, 37 (3):293-7. [Details]
Clarkson, M. R.,Gupta, S.,Murphy, M.,Martin, F.,Godson, C.,Brady, H. R.; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Curr Opin Nephrol Hypertens, 8 (5):543-8. [Details]
Adler, S.,Brady, H. R.; (1999) 'Cell adhesion molecules and the glomerulopathies'. Am J Med, 107 (4):371-86. [Details]
Higgins, J. R.,Papayianni, A.,Brady, H. R.,Darling, M. R.,Walshe, J. J.; (1998) 'Circulating vascular cell adhesion molecule-1 in pre-eclampsia, gestational hypertension, and normal pregnancy: evidence of selective dysregulation of vascular cell adhesion molecule-1 homeostasis in pre-eclampsia'. Am J Obstet Gynecol, 179 (2):464-9. [Details]
Hebert, M. J.,Takano, T.,Papayianni, A.,Rennke, H. G.,Minto, A.,Salant, D. J.,Carroll, M. C.,Brady, H. R.; (1998) 'Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria'. Nephrol Dial Transplant, 13 (11):2799-803. [Details]
Hebert, M. J.,Gullans, S. R.,Mackenzie, H. S.,Brady, H. R.; (1998) 'Apoptosis of endothelial cells is associated with paracrine induction of adhesion molecules: evidence for an interleukin-1beta-dependent paracrine loop'. Am J Pathol, 152 (2):523-32. [Details]
Healy, E.,Brady, H. R.; (1998) 'Role of tubule epithelial cells in the pathogenesis of tubulointerstitial fibrosis induced by glomerular disease'. Curr Opin Nephrol Hypertens, 7 (5):525-30. [Details]
Clarkson, M. R.,O'Meara, Y. M.,Murphy, B.,Rennke, H. G.,Brady, H. R.; (1998) 'Collapsing glomerulopathy--recurrence in a renal allograft'. Nephrol Dial Transplant, 13 (2):503-6. [Details]
Clarkson, M. R.,McGinty, A.,Godson, C.,Brady, H. R.; (1998) 'Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrol Dial Transplant, 13 (12):3043-51. [Details]
Brady, H. R.; (1998) 'Fibrillary glomerulopathy'. Kidney Int, 53 (5):1421-9. [Details]
Takano, T.,Fiore, S.,Maddox, J. F.,Brady, H. R.,Petasis, N. A.,Serhan, C. N.; (1997) 'Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors'. J Exp Med, 185 (9):1693-704. [Details]
Brady, H. R.,Papayianni, A.,Serhan, C. N.; (1997) 'Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis'. Adv Exp Med Biol, 400B :631-40. [Details]
Chertow, G. M.,Rennke, H. G.,Curhan, G. C.,Brady, H. R.; (1997) 'Renal vasculitis with HIV seropositivity: potential manifestation of cytomegalovirus infection'. Am J Kidney Dis, 30 (3):428-32. [Details]
O'Meara, Y. M.,Brady, H. R.; (1997) 'Lipoxins, leukocyte recruitment and the resolution phase of acute glomerulonephritis'. Kidney Int Suppl, 58 :S56-61. [Details]
Rabb, H.,O'Meara, Y. M.,Maderna, P.,Coleman, P.,Brady, H. R.; (1997) 'Leukocytes, cell adhesion molecules and ischemic acute renal failure'. Kidney Int, 51 (5):1463-8. [Details]
Papayianni, A.,Serhan, C. N.,Brady, H. R.; (1996) 'Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells'. J Immunol, 156 (6):2264-72. [Details]
Brady, H. R.; (1996) 'Complex roles for P-selectin in the pathophysiology of glomerulonephritis'. Curr Opin Nephrol Hypertens, 5 (5):423-6. [Details]
Madore, F.,Lazarus, J. M.,Brady, H. R.; (1996) 'Therapeutic plasma exchange in renal diseases'. J Am Soc Nephrol, 7 (3):367-86. [Details]
Hebert, M. J.,Takano, T.,Holthofer, H.,Brady, H. R.; (1996) 'Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids'. J Immunol, 157 (7):3105-15. [Details]
Gilligan, H. M.,Bredy, B.,Brady, H. R.,Hebert, M. J.,Slayter, H. S.,Xu, Y.,Rauch, J.,Shia, M. A.,Koh, J. S.,Levine, J. S.; (1996) 'Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming'. J Exp Med, 184 (6):2231-41. [Details]
Brady, H. R.,Serhan, C. N.; (1996) 'Lipoxins: putative braking signals in host defense, inflammation and hypersensitivity'. Curr Opin Nephrol Hypertens, 5 (1):20-7. [Details]
Denton, M. D.,Chertow, G. M.,Brady, H. R.; (1996) '"Renal-dose" dopamine for the treatment of acute renal failure: scientific rationale, experimental studies and clinical trials'. Kidney Int, 50 (1):4-14. [Details]
Pronovost, P. H.,Brady, H. R.,Gunning, M. E.,Espinoza, O.,Rennke, H. G.; (1996) 'Clinical features, predictors of disease progression and results of renal transplantation in fibrillary/immunotactoid glomerulopathy'. Nephrol Dial Transplant, 11 (5):837-42. [Details]
Mayadas, T. N.,Mendrick, D. L.,Brady, H. R.,Tang, T.,Papayianni, A.,Assmann, K. J.,Wagner, D. D.,Hynes, R. O.,Cotran, R. S.; (1996) 'Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice'. Kidney Int, 49 (5):1342-9. [Details]
Serhan, C. N.,Maddox, J. F.,Petasis, N. A.,Akritopoulou-Zanze, I.,Papayianni, A.,Brady, H. R.,Colgan, S. P.,Madara, J. L.; (1995) 'Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils'. Biochemistry, 34 (44):14609-15. [Details]
Colgan, S. P.,Parkos, C. A.,McGuirk, D.,Brady, H. R.,Papayianni, A. A.,Frendl, G.,Madara, J. L.; (1995) 'Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions'. J Biol Chem, 270 (18):10531-9. [Details]
Brady, H. R.,Singer, G. G.; (1995) 'Acute renal failure'. Lancet, 346 (8989):1533-40. [Details]
Brady, H. R.,Lamas, S.,Papayianni, A.,Takata, S.,Matsubara, M.,Marsden, P. A.; (1995) 'Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction'. Am J Physiol, 268 (1 Pt 2):F1-12. [Details]
Takano, T.,Brady, H. R.; (1995) 'The endothelium in glomerular inflammation'. Curr Opin Nephrol Hypertens, 4 (3):277-86. [Details]
Papayianni, A.,Serhan, C. N.,Phillips, M. L.,Rennke, H. G.,Brady, H. R.; (1995) 'Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis'. Kidney Int, 47 (5):1295-302. [Details]
Takata, S.,Papayianni, A.,Matsubara, M.,Jimenez, W.,Pronovost, P. H.,Brady, H. R.; (1994) '15-Hydroxyeicosatetraenoic acid inhibits neutrophil migration across cytokine-activated endothelium'. Am J Pathol, 145 (3):541-9. [Details]
Takata, S.,Matsubara, M.,Allen, P. G.,Janmey, P. A.,Serhan, C. N.,Brady, H. R.; (1994) 'Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium'. J Clin Invest, 93 (2):499-508. [Details]
Kelly, C. P.,Keates, S.,Siegenberg, D.,Linevsky, J. K.,Pothoulakis, C.,Brady, H. R.; (1994) 'IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells'. Am J Physiol, 267 (6 Pt 1):G991-7. [Details]
Chertow, G. M.,Brady, H. R.; (1994) 'Hyponatraemia from tap-water enema'. Lancet, 344 (8924). [Details]
Brady, H. R.,Papayianni, A.,Serhan, C. N.; (1994) 'Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes'. Kidney Int Suppl, 45 :S90-7. [Details]
Brady, H. R.; (1994) 'Leukocyte adhesion molecules and kidney diseases'. Kidney Int, 45 (5):1285-300. [Details]
Brady, H. R.,Zeidel, M. L.,Kone, B. C.,Giebisch, G.,Gullans, S. R.; (1993) 'Differential actions of cisplatin on renal proximal tubule and inner medullary collecting duct cells'. J Pharmacol Exp Ther, 265 (3):1421-8. [Details]
Brady, H. R.; (1993) 'Leukocyte adhesion molecules: potential targets for therapeutic intervention in kidney diseases'. Curr Opin Nephrol Hypertens, 2 (2):171-82. [Details]
Lynch, T.,Kinirons, M. T.,O'Callaghan, D.,Ismail, S.,Brady, H. R.,Horgan, J. H.; (1992) 'Metabolic changes during serial squash matches in older men'. Can J Sport Sci, 17 (2):110-3. [Details]
Kelly, C. P.,O'Keane, J. C.,Orellana, J.,Schroy, P. C., 3rd,Yang, S.,LaMont, J. T.,Brady, H. R.; (1992) 'Human colon cancer cells express ICAM-1 in vivo and support LFA-1-dependent lymphocyte adhesion in vitro'. Am J Physiol, 263 (6 Pt 1):G864-70. [Details]
Brady, H. R.,Serhan, C. N.; (1992) 'Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin'. Biochem Biophys Res Commun, 186 (3):1307-14. [Details]
Brady, H. R.,Denton, M. D.,Jimenez, W.,Takata, S.,Palliser, D.,Brenner, B. M.; (1992) 'Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury'. Kidney Int, 42 (2):480-7. [Details]
Brady, H. R.,Spertini, O.,Jimenez, W.,Brenner, B. M.,Marsden, P. A.,Tedder, T. F.; (1992) 'Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro'. J Immunol, 149 (7):2437-44. [Details]
Gunning, M. E.,Brady, H. R.,Otuechere, G.,Brenner, B. M.,Zeidel, M. L.; (1992) 'Atrial natriuretic peptide(31-67) inhibits Na+ transport in rabbit inner medullary collecting duct cells. Role of prostaglandin E2'. J Clin Invest, 89 (5):1411-7. [Details]
Zeidel, M. L.,Brady, H. R.,Kohan, D. E.; (1991) 'Interleukin-1 inhibition of Na(+)-K(+)-ATPase in inner medullary collecting duct cells: role of PGE2'. Am J Physiol, 261 (6 Pt 2):F1013-6. [Details]
Stromski, M. E.,Brady, H. R.,Gullans, S. R.,Patz, S.; (1991) 'Application of missing pulse steady state free precession to the study of renal microcirculation'. Magn Reson Med, 20 (1):66-77. [Details]
Mulkern, R. V.,Stromski, M. E.,Brady, H. R.,Gullans, S. R.,Sandor, T.,Jolesz, F. A.; (1991) 'Regional 1H transverse magnetization studies in perfused rabbit kidney'. Magn Reson Med, 20 (1):78-88. [Details]
Denton, M. D.,Marsden, P. A.,Luscinskas, F. W.,Brenner, B. M.,Brady, H. R.; (1991) 'Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1'. Am J Physiol, 261 (6 Pt 2):F1071-9. [Details]
Brady, H. R.,Denton, M. D.,Brenner, B. M.,Serhan, C. N.; (1991) 'Neutrophil adhesion to glomerular mesangial cells: regulation by lipoxygenase-derived eicosanoids'. Adv Exp Med Biol, 314 :347-59. [Details]
Lafferty, H. M.,Gunning, M.,Brady, H. R.,Brenner, B. M.,Anderson, S.; (1990) 'Renal hemodynamic and natriuretic effects of manganese and interactions with atrial natriuretic peptide'. Am J Physiol, 258 (4 Pt 2):F998-1004. [Details]
Brady, H. R.,Kamel, K. S.,Harding, M. E.,Cook, G. T.,deVeber, G. A.,Cardella, C. J.; (1990) 'Low dose ciclosporin from the early postoperative period yields potent immunosuppression after renal transplantation'. Nephron Exp Nephrol, 55 (4):394-9. [Details]
Brady, H. R.,Persson, U.,Ballermann, B. J.,Brenner, B. M.,Serhan, C. N.; (1990) 'Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins'. Am J Physiol, 259 (5 Pt 2):F809-15. [Details]
Brady, H. R.,Kone, B. C.,Stromski, M. E.,Zeidel, M. L.,Giebisch, G.,Gullans, S. R.; (1990) 'Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules'. Am J Physiol, 258 (5 Pt 2):F1181-7. [Details]
Zeidel, M. L.,Brady, H. R.,Kone, B. C.,Gullans, S. R.,Brenner, B. M.; (1989) 'Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells'. Am J Physiol, 257 (6 Pt 1):C1101-7. [Details]
Brady, H. R.,Fay, W. P.,Meema, H. E.,Rabinovich, S.,Rapoport, A.,Oreopoulos, D. G.; (1989) 'Oxalate bone disease--an emerging form of renal osteodystrophy'. Int J Artif Organs, 12 (11):715-9. [Details]
Brady, H. R.,Fitzcharles, B.,Goldberg, H.,Huraib, S.,Richardson, T.,Simons, M.,Uldall, P. R.; (1989) 'Diagnosis and management of subclavian vein thrombosis occurring in association with subclavian cannulation for hemodialysis'. Blood Purif, 7 (4):210-7. [Details]
Kone, B. C.,Brady, H. R.,Gullans, S. R.; (1989) 'Coordinated regulation of intracellular K+ in the proximal tubule: Ba2+ blockade down-regulates the Na+,K+-ATPase and up-regulates two K+ permeability pathways'. Proc Natl Acad Sci U S A, 86 (16):6431-5. [Details]
Brady, H. R.,Ryan, F.,Cunningham, J.,Tormey, W.,Ryan, M. P.,O'Neill, S.; (1989) 'Hypophosphatemia complicating bronchodilator therapy for acute severe asthma'. Arch Intern Med, 149 (10):2367-8. [Details]
Brady, H. R.,Kinirons, M.,Lynch, T.,Ohman, E. M.,Tormey, W.,O'Malley, K. M.,Horgan, J. H.; (1989) 'Heart rate and metabolic response to competitive squash in veteran players: identification of risk factors for sudden cardiac death'. Eur Heart J, 10 (11):1029-35. [Details]
Brady, H. R.,Kone, B. C.,Brenner, R. M.,Gullans, S. R.; (1989) 'Early effects of uranyl nitrate on respiration and K+ transport in rabbit proximal tubule'. Kidney Int, 36 (1):27-34. [Details]
Brady, H. R.,Kone, B. C.,Gullans, S. R.; (1989) 'Extracellular Na+ electrode for monitoring net Na+ flux in cell suspensions'. Am J Physiol, 256 (5 Pt 1):C1105-10. [Details]
Huraib, S. O.,Wijeyesinghe, C. R.,Brady, H. R.,Holtzer, C.,Watson, A. R.,Uldall, P. R.; (1988) 'The WBW jugular catheter as long term vascular access for hemodialysis'. Int J Artif Organs, 11 (2):99-101. [Details]
Godson, C.,Ryan, M. P.,O'Halloran, D.,Bourke, S.,Brady, H. R.,FitzGerald, M. X.; (1988) 'Investigation of aminoglycoside nephrotoxicity in cystic fibrosis patients'. Scand J Gastroenterol Suppl, 143 :70-3. [Details]
Godson, C.,Ryan, M. P.,Brady, H. R.,Bourke, S.,FitzGerald, M. X.; (1988) 'Acute hypomagnesaemia complicating the treatment of meconium ileus equivalent in cystic fibrosis'. Scand J Gastroenterol Suppl, 143 :148-50. [Details]
Brady, H. R.,Peters, P.,Cardella, C. J.; (1988) 'Synergistic effects of cyclosporine and rabbit antithymocyte sera on suppression of the one-way allogeneic mixed lymphocyte response'. Transplant Proc, 20 (2 Suppl 2):229-32. [Details]
Brady, H. R.,Horgan, J. H.; (1988) 'Lithium and the heart. Unanswered questions'. Chest, 93 (1):166-9. [Details]
Brady, H. R.,Goldberg, H.,Lunski, C.,Uldall, P. R.; (1988) 'Dialysis-induced hyperkalaemia presenting as profound muscle weakness'. Int J Artif Organs, 11 (1):43-4. [Details]
Cardella, C. J.,Pei, Y.,Brady, H. R.; (1987) 'ABO blood group incompatible kidney transplantation: a case report and review of the literature'. Clin Nephrol, 28 (6):295-9. [Details]
Brady, H. R.,Quigley, C.,Stafford, F. J.,Bresnihan, B.,Hourihane, B.,FitzGerald, M. X.; (1987) 'Popliteal cyst rupture and the pseudothrombophlebitis syndrome'. Ann Emerg Med, 16 (10):1151-4. [Details]
Brady, H. R.,Corcoran, G. D.,Kelly, G.,Keaveny, T. V.,Blake, J.; (1986) 'Real-time carotid ultrasonography and wave-speed oculoplethysmography: a useful combination in the screening for carotid occlusive disease in ocular embolism'. Ir J Med Sci, 155 (2):45-50. [Details]
Kinnas, S. J.,Brady, H. R.; (1985) 'Oedipism and Down's syndrome: case report and review of the literature'. Ann Ophthalmol, 17 (7):431-3. [Details]
Ryan, M. P.,Brady, H. R.; (1984) 'The role of magnesium in the prevention and control of hypertension'. Ann Clin Res, 16 Suppl 43 :81-8. [Details]
O'Higgins, N.,Brady, H. R.,Clark, C. G.; (1984) 'Factors influencing survival and recurrence-free intervals after treatment of primary breast cancer'. Ir Med J, 77 (7):197-202. [Details]
Purcell, J. J., Jr.,Brady, H. R.; (1983) 'Intrastromal epithelial corneal cyst'. Ophthalmic Surg, 14 (6):491-3. [Details]
Brady, H. R.,O'Donoghue, D. P.; (1983) 'Colorectal polyps--an Irish experience'. Ir J Med Sci, 152 (10):377-81. [Details]
Brady, H. R.,Hecke, D.,Culliton, P.; (1983) 'New instruments and products. Spectacle-mounted telescopic lenses for children'. Ann Ophthalmol, 15 (3):286-9. [Details]
Lewis, R. D.,Brady, H. R.; (1977) 'Visual rehabilitation in the 'blind': case reports'. Mo Med, 74 (11):641-2. [Details]
Brady, H. R.; (1975) 'Reusable self retaining iris retractor'. Ann Ophthalmol, 7 (7):1008-9. [Details]
Calderon, M.,Brady, H. R.; (1969) 'Fibrous dysplasia of bone with bilateral optic foramina involvement'. Am J Ophthalmol, 68 (3):513-5. [Details]
Brady, H. R.; (1969) 'Conract lens therapy in infants and children: preliminary report of cases'. J Am Osteopath Assoc, 69 (2):165-7. [Details]
Brady, H. R.,Bowen, S. F., Jr.,Scheller, A. J.; (1966) 'Absorption of catgut related to corneal geography'. Am J Ophthalmol, 61 (2):323-7. [Details]
Mattis, R. D.,Brady, H. R.,Sugana, T.; (1965) 'Disposable cryophake--clinical evaluation'. Arch Ophthalmol, 74 (6):787-91. [Details]
Brady, H. R.,Paul, H. R.,Rogers, K. D.,Thompson, D. J.,Gezon, H. M.; (1962) 'Air contamination and staphylococcal infection. Relation to nursery crowding'. Am J Dis Child, 103 :27-34. [Details]