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Researchers at UCD

researcher

John M P Hyland

Associate Clinical Professor

School Of Medicine & Medical Science
St Vincent's Hospital
Elm Park
Dublin 4

Tel: +353 1 716
Email: prof.j.hyland@svcpc.ie

Professional

         

Conference Contributions

Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Biomarker identification in colon cancer via real-time reverse transcriptase-PCR. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Coss A, Sheahan K, Sullivan S, Fox E, Hyland J, O'Donoghue D, Leahy D, Mulcahy H, O'Sullivan J; (2007) Alterations of the topoisomerase II alpha gene and protein in colorectal cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Cork, March, 2007 , 02-MAR-07.
               

Publications

     

Peer Reviewed Journals

Moriarty, D; Ettarh, R; Sheahan, K; Hyland, J; O'Donoghue, DP; Baird, AW; ; (1998) 'Structural associations between mast cells and enteric nerves in normal and inflamed human colon'. Gastroenterology, 114 (4):400-400. [Details]
McCormack, G; McCormick, PA; Hyland, J; Baird, A; O'Donoghue, D; ; (1999) 'Patient targeted therapy - The use of cyclosporin in the treatment of acute ulcerative colitis'. Gut, 44 (NA):37-37. [Details]
Moriarty, DV; O'Riordan, A; O'Donoghue, DP; Hyland, J; Sheahan, K; Baird, AW; ; (2000) 'Substance P release and modulation of human colonic ion transport: Alterations during IBD'. Gastroenterology, 118 (4):1105-1105. [Details]
Mofidi, R., Neary, P., Brabazon, A., White, A., Ryan, R.E., Sheehan, S.J., ODonoghue, D. & Hyland, J.M.P.; (2002) 'Assessment of outcome from colorectal carcinoma using an artificial neural network'. British Journal of Surgery, 89 (5):639-640. [Details]
R Mofidi, R., Neary, P., Brabazon, A., White, A., Ryan, R., Sheahan, K. ODonoghue, D. & Hyland, J; (2003) 'Prediction of Local Recurrence from Rectal Carcinoma Using an Artificial Neural Network'. Colorectal Disease, 5 (2). [Details]
Bakhiet, S; O'Sullivan, J; Izzuan, M; Keating, G; Gorman, J; Mulcahy, H; Hyland, J; O'Donoghue, D; Sheahan, K; ; (2006) 'GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers'. Modern Pathology, 19 (NA):55-55. [Details]
Bakhiet, S, O'Sullivan, J, Izzuan, M, Keating, G, Gorman, J, Mulcahy, H, Hyland, J, O'Donoghue, D, Sheahan, K, ; (2006) 'GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers'. MODERN PATHOL, 19 (NA):55-55. [DOI] [Details]
Banville, N.,Geraghty, R.,Fox, E.,Leahy, D. T.,Green, A.,Keegan, D.,Geoghegan, J.,O'Donoghue, D.,Hyland, J.,Sheahan, K.; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Hum Pathol, 37 (11):1498-502. [Details]
Fox, E. J.,Leahy, D. T.,Geraghty, R.,Mulcahy, H. E.,Fennelly, D.,Hyland, J. M.,O'Donoghue, D. P.,Sheahan, K.; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Cullen, G.,O'Toole, A.,Keegan, D.,Sheahan, K.,Hyland, J. M.,O'Donoghue D, P.; (2007) 'Long-term clinical results of ileocecal resection for Crohn's disease'. Inflamm Bowel Dis, 13 (11):1369-73. [Details]
Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O¿Donoghue D, Sheahan K, Leahy D, Mulcahy H, O¿Sullivan J; (2008) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. CANCER LETT, . [Details]
Canney, A,Sheahan, K,Keegan, D,Tolan, M,Hyland, J,Green, A; (2009) 'Synchronous lung tumours in a patient with metachronous colorectal carcinoma and a germline MSH2 mutation'. J Clin Pathol, 62 :471-473. [DOI] [Details]
Doherty G, Walsh P, Sheridan J, Kevans D, Keegan D, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H (2010) 'Clinical and pathological factors associated with colorectal cancer at the upper extreme of life'. Journal of the American Geriatrics Society, 58 (4):794-795. [DOI] [Details]
Smith, FM,Chang, KH,Sheahan, K,Hyland, J,O'Connell, PR,Winter, DC (2012) 'The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy'. British Journal of Surgery, 99 :993-1001. [DOI] [Details]
 

Conference Publications

Geraghty, R; Leahy, D; Keegan, D; Mulcahy, H; O'Donoghue, D; Hyland, J; Sheahan, K; ; (2006) MODERN PATHOLOGY 19: Suppl. 3, 60 Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tumors [Details]
Leahy DT, Milewski M, Fox E, Geraghty R, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2009) MODERN PATHOLOGY 22: Suppl. 1, 137 Role of E-Cadherin and Beta-Catenin in Colorectal Cancer Progression [Details]
Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) LABORATORY INVESTIGATION 90: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) MODERN PATHOLOGY 23: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
   

Editorial

Cleary, M,Coss, A,Sheahan, K,Mulcahy, H,Hyland, J; (2004) Dieulafoy's lesion in a Meckel's diverticulum. Editorial [Details]
                 

Abstract

Moriarty, D,Ettarh, R,Sheahan, K,Hyland, J,O'Donoghue, DP,Baird, AW (1998) Structural associations between mast cells and enteric nerves in normal and inflamed human colon. Abstract [Details]
McCormack, G,McCormick, PA,Hyland, J,Baird, A,O'Donoghue, D (1999) Patient targeted therapy - The use of cyclosporin in the treatment of acute ulcerative colitis. Abstract [Details]
Moriarty, DV,O'Riordan, A,O'Donoghue, DP,Hyland, J,Sheahan, K,Baird, AW (2000) Substance P release and modulation of human colonic ion transport: Alterations during IBD. Abstract [Details]
Bakheit, S,Dolan, J,O'Sullivan, J,Keating, G,Gorman, J,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2005) Glucose Transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia. Abstract [Details]
Geraghty, R,Leahy, D,Keegan, D,Mulcahy, H,O'Donoghue, D,Hyland, J,Sheahan, K (2006) Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tuniors. Abstract [Details]
Bakhiet, S,O'Sullivan, J,Izzuan, M,Keating, G,Gorman, J,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2006) GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers. Abstract [Details]
Sheridan, J,Wang, LM,Fox, E,Dermot, L,Sheahan, K,Hyland, J,O'Donoghue, D,Mulcahy, H,O'Sullivan, J (2006) Higher levels of oxidative damage and tumour infiltrating lymphocytes in non-metastatic versus metastatic colorectal tumours. Abstract [Details]
Leahy, DT,Milewski, M,Fox, E,Geraghty, R,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2009) Role of E-Cadherin and Beta-Catenin in Colorectal Cancer Progression. Abstract [Details]
Maguire, A,Biniecka, M,Geraghty, R,Hyland, J,O'Donoghue, D,Mulcahy, H,O'Sullivan, J,Sheahan, K (2010) Levels of Lipid Peroxidation Are an Important Stimulus in Driving the Adenoma-Carcinoma Sequence in Colorectal Cancer. Abstract [Details]
Maguire, A,Biniecka, M,Geraghty, R,Hyland, J,O'Donoghue, D,Mulcahy, H,O'Sullivan, J,Sheahan, K (2010) Levels of Lipid Peroxidation Are an Important Stimulus in Driving the Adenoma-Carcinoma Sequence in Colorectal Cancer. Abstract [Details]
Milewski, MA,Leahy, DT,Conroy, J,Ennis, S,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2010) Genome-Wide DNA Methylation Profiling of Sporadic and Familial Colorectal Cancer. Abstract [Details]
Noonan, S,Martin, P,Maguire, A,Biniecka, M,Tosetto, M,Hyland, J,Sheahan, K,O'Donoghue, D,Mulcahy, H,Fennelly, D,O'Sullivan, J (2012) Correlation of markers of oxidative damage and circulating IL6 levels with survival following treatment with bevacizumab in metastatic colorectal cancer patients. Abstract [Details]
Maguire, A,Sheahan, K,Fox, E,Martin, P,Hughes, D,Geraghty, R,Swan, N,Mulcahy, H,Hyland, J,O'Donoghue, D,O'Sullivan, J (2012) Mitochondrial Mutagenesis and Inflammation in the Colorectal Adenoma-Carcinoma Sequence. Abstract [Details]
Milewski, M,Leahy, D,Conroy, J,Magalhaes, T,Ennis, S,Maguire, A,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2013) Classification of Colorectal Cancer Based on DNA Methylation Array Analysis. Abstract [Details]
                                                             

Letters

Doherty, G,Walsh, P,Sheridan, J,Kevans, D,Keegan, D,Nolan, B,White, A,McDermott, E,Sheahan, K,O'Shea, D,Hyland, J,O'Donoghue, D,O'Sullivan, J,Mulcahy, H (2010) Clinical and Pathological Factors Associated with Colorectal Cancer at the Upper Extreme of Life. Letters [Details]