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Researchers at UCD

Kenneth McDonald

Associate Clinical Professor

School Of Medicine & Medical Science
St Vincent's Hospital
Elm Park
Dublin 4

Tel: 012304629
Email: kenneth.mcdonald@ucd.ie

Publications

     

Peer Reviewed Journals

Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
Bermingham, M. and Ryder, M. and Travers, B. and Edwards, N. and Lalor, L. and Kelly, D. and Gallagher, J. and O'Hanlon, R. and McDonald, K. and Ledwidge, M. (2014) 'The St Vincent's potentially inappropriate medicines study: Development of a disease-specific consensus list and its evaluation in ambulatory heart failure care'. European Journal of Heart Failure, 16 (8):915-922. Available Online [DOI] [Details]
Bermingham, M. and Shanahan, M.K. and O'Connell, E. and Dawkins, I. and Miwa, S. and O'Hanlon, R. and Gilmer, J. and McDonald, K. and Ledwidge, M. (2014) 'Aspirin use in heart failure is low-dose therapy associated with mortality and morbidity benefits in a large community population?'. Circulation: Heart Failure, 7 (2):243-250. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Collier, P. and Horgan, S. and Glezeva, N. and Cooke, G. and Xu, M. and Ledwidge, M. and Mcdonald, K. and Baugh, J.A. (2014) 'Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta'. Connective Tissue Research, 55 (3):248-256. Available Online [DOI] [Details]
James, S. and Waterhouse, D. and McDonald, K. and O'Hanlon, R. (2014) 'Dilated cardiomyopathy and progressive familial intrahepatic cholestasis'. BMJ Case Reports, . Available Online [DOI] [Details]
Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
Bermingham, M. and Ryder, M. and Travers, B. and Edwards, N. and Lalor, L. and Kelly, D. and Gallagher, J. and O'Hanlon, R. and McDonald, K. and Ledwidge, M. (2014) 'The St Vincent's potentially inappropriate medicines study: Development of a disease-specific consensus list and its evaluation in ambulatory heart failure care'. European Journal of Heart Failure, 16 (8):915-922. Available Online [DOI] [Details]
Bermingham, M. and Shanahan, M.K. and O'Connell, E. and Dawkins, I. and Miwa, S. and O'Hanlon, R. and Gilmer, J. and McDonald, K. and Ledwidge, M. (2014) 'Aspirin use in heart failure is low-dose therapy associated with mortality and morbidity benefits in a large community population?'. Circulation: Heart Failure, 7 (2):243-250. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Collier, P. and Horgan, S. and Glezeva, N. and Cooke, G. and Xu, M. and Ledwidge, M. and Mcdonald, K. and Baugh, J.A. (2014) 'Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta'. Connective Tissue Research, 55 (3):248-256. Available Online [DOI] [Details]
Glezeva, N. and Collier, P. and Voon, V. and Ledwidge, M. and McDonald, K. and Watson, C. and Baugh, J. (2013) 'Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide'. Journal of Cardiovascular Translational Research, 6 (4):545-557. Available Online [DOI] [Details]
Jan, A. and Dawkins, I. and Murphy, N. and Collier, P. and Baugh, J. and Ledwidge, M. and McDonald, K. and Watson, C.J. (2013) 'Associates of an elevated natriuretic peptide level in stable heart failure patients: Implications for targeted management'. The Scientific World Journal, 2013 . Available Online [DOI] [Details]
Ledwidge, M.T. and O'Hanlon, R. and Lalor, L. and Travers, B. and Edwards, N. and Kelly, D. and Voon, V. and McDonald, K.M. (2013) 'Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?'. European journal of heart failure, 15 (4):447-455. Available Online [DOI] [Details]
Dahlström, U. and Mcdonald, K. and Maisel, A. (2013) 'Integration of B-Type natriuretic peptide in heart failure outpatient programs'. Congestive Heart Failure, 14 (4). Available Online [DOI] [Details]
Mcdonagh, T.A. and Mcdonald, K. and Maisel, A.S. (2013) 'Screening for asymptomatic left ventricular dysfunction using B-type natriuretic peptide'. Congestive Heart Failure, 14 (4). Available Online [DOI] [Details]
Ledwidge, M. and Gallagher, J. and Conlon, C. and Tallon, E. and O'Connell, E. and Dawkins, I. and Watson, C. and O'Hanlon, R. and Bermingham, M. and Patle, A. and Badabhagni, M.R. and Murtagh, G. and Voon, V. and Tilson, L. and Barry, M. and McDonald, L. and Maurer, B. and McDonald, K. (2013) 'Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial'. JAMA - Journal of the American Medical Association, 310 (1):66-74. Available Online [DOI] [Details]
Glezeva, N. and Collier, P. and Voon, V. and Ledwidge, M. and McDonald, K. and Watson, C. and Baugh, J. (2013) 'Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide'. Journal of Cardiovascular Translational Research, 6 (4):545-557. Available Online [DOI] [Details]
Jan, A. and Dawkins, I. and Murphy, N. and Collier, P. and Baugh, J. and Ledwidge, M. and McDonald, K. and Watson, C.J. (2013) 'Associates of an elevated natriuretic peptide level in stable heart failure patients: Implications for targeted management'. The Scientific World Journal, 2013 . Available Online [DOI] [Details]
Ledwidge, M.T. and O'Hanlon, R. and Lalor, L. and Travers, B. and Edwards, N. and Kelly, D. and Voon, V. and McDonald, K.M. (2013) 'Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?'. European journal of heart failure, 15 (4):447-455. Available Online [DOI] [Details]
Ledwidge, M. and Gallagher, J. and Conlon, C. and Tallon, E. and O'Connell, E. and Dawkins, I. and Watson, C. and O'Hanlon, R. and Bermingham, M. and Patle, A. and Badabhagni, M.R. and Murtagh, G. and Voon, V. and Tilson, L. and Barry, M. and McDonald, L. and Maurer, B. and McDonald, K. (2013) 'Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial'. JAMA - Journal of the American Medical Association, 310 (1):66-74. Available Online [DOI] [Details]
Phelan, D. and Watson, C. and Martos, R. and Collier, P. and Patle, A. and Donnelly, S. and Ledwidge, M. and Baugh, J. and McDonald, K. (2012) 'Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes'. PLoS ONE, 7 (11). Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and van Es, M.H. and Phelan, D. and McGorrian, C. and Tolan, M. and Ledwidge, M.T. and McDonald, K.M. and Baugh, J.A. (2012) 'Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype'. Journal of Molecular and Cellular Cardiology, 52 (1):148-153. Available Online [DOI] [Details]
Abulhul, E. and McDonald, K. and Martos, R. and Phelan, D. and Spiers, J.P. and Hennessy, M. and Baugh, J. and Watson, C. and O'Loughlin, C. and Ledwidge, M. (2012) 'Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide'. Clinical Therapeutics, 34 (1):91-100. Available Online [DOI] [Details]
Collier, P. and McDonald, K.M. (2012) 'The Role of Renin Angiotensin System Intervention in Stage B Heart Failure'. Heart Failure Clinics, 8 (2):225-236. Available Online [DOI] [Details]
Murtagh, G. and Dawkins, I.R. and O'Connell, R. and Badabhagni, M. and Patel, A. and Tallon, E. and O'Hanlon, R. and Ledwidge, M.T. and McDonald, K.M. (2012) 'Screening to prevent heart failure (STOP-HF): Expanding the focus beyond asymptomatic left ventricular systolic dysfunction'. European Journal of Heart Failure, 14 (5):480-486. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Xu, M. and Collier, P. and Neary, R. and Smolenski, A. and Ledwidge, M. and McDonald, K. and Baugh, J. (2012) 'Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis'. Fibrogenesis and Tissue Repair, 5 (1). Available Online [DOI] [Details]
Collier, P. and Ledwidge, M. and McDonald, K. (2012) 'Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology'. QJM, 105 (8):721-724. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Waterhouse, D.F. and Dawkins, I.R. and Patle, A.K. and Horgan, S. and Conlon, C.M. and O'Hanlon, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K. (2012) 'Progression of left atrial volume index in a population at risk for heart failure: A substudy of the STOP-HF (St Vincent's Screening to Prevent Heart Failure) trial'. European Journal of Heart Failure, 14 (9):957-964. Available Online [DOI] [Details]
Phelan, D. and Watson, C. and Martos, R. and Collier, P. and Patle, A. and Donnelly, S. and Ledwidge, M. and Baugh, J. and McDonald, K. (2012) 'Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes'. PLoS ONE, 7 (11). Available Online [DOI] [Details]
McDonald, K. and Dahlström, U. (2012) 'Natriuretic peptides - addressing the dilemma of heart failure management'. Interventional Cardiology (London), 7 (2):104-107. Available Online [Details]
Collier, P. and Watson, C.J. and van Es, M.H. and Phelan, D. and McGorrian, C. and Tolan, M. and Ledwidge, M.T. and McDonald, K.M. and Baugh, J.A. (2012) 'Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype'. Journal of Molecular and Cellular Cardiology, 52 (1):148-153. Available Online [DOI] [Details]
Abulhul, E. and McDonald, K. and Martos, R. and Phelan, D. and Spiers, J.P. and Hennessy, M. and Baugh, J. and Watson, C. and O'Loughlin, C. and Ledwidge, M. (2012) 'Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide'. Clinical Therapeutics, 34 (1):91-100. Available Online [DOI] [Details]
Murtagh, G. and Dawkins, I.R. and O'Connell, R. and Badabhagni, M. and Patel, A. and Tallon, E. and O'Hanlon, R. and Ledwidge, M.T. and McDonald, K.M. (2012) 'Screening to prevent heart failure (STOP-HF): Expanding the focus beyond asymptomatic left ventricular systolic dysfunction'. European Journal of Heart Failure, 14 (5):480-486. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Xu, M. and Collier, P. and Neary, R. and Smolenski, A. and Ledwidge, M. and McDonald, K. and Baugh, J. (2012) 'Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis'. Fibrogenesis and Tissue Repair, 5 (1). Available Online [DOI] [Details]
Collier, P. and Ledwidge, M. and McDonald, K. (2012) 'Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology'. QJM, 105 (8):721-724. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Waterhouse, D.F. and Dawkins, I.R. and Patle, A.K. and Horgan, S. and Conlon, C.M. and O'Hanlon, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K. (2012) 'Progression of left atrial volume index in a population at risk for heart failure: A substudy of the STOP-HF (St Vincent's Screening to Prevent Heart Failure) trial'. European Journal of Heart Failure, 14 (9):957-964. Available Online [DOI] [Details]
Bermingham, M. and McDonald, K. and Ledwidge, M. (2011) 'The authors respond:'. Clinical Therapeutics, 33 (12). Available Online [DOI] [Details]
Watson, C.J. and Ledwidge, M.T. and Phelan, D. and Collier, P. and Byrne, J.C. and Dunn, M.J. and McDonald, K.M. and Baugh, J.A. (2011) 'Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure'. Circulation: Heart Failure, 4 (2):188-197. Available Online [DOI] [Details]
McDonagh, T.A. and Blue, L. and Clark, A.L. and Dahlström, U. and Ekman, I. and Lainscak, M. and McDonald, K. and Ryder, M. and Ströxmberg, A. and Jaarsma, T. (2011) 'European Society of Cardiology Heart Failure Association Standards for delivering heart failure care'. European Journal of Heart Failure, 13 (3):235-241. Available Online [DOI] [Details]
Conlon, C.M. and Dawkins, I. and O'Loughlin, C. and Gibson, D. and Kelleher, C.C. and Ledwidge, M. and McDonald, K. (2011) 'B-type natriuretic peptide measurement in primary care; Magnitude of associations with cardiovascular risk factors and their therapies. Observations from the STOP-HF (St. Vincent's Screening to Prevent Heart Failure) study'. Clinical Chemistry and Laboratory Medicine, 49 (4):719-728. Available Online [DOI] [Details]
Jan, A. and Murphy, N.F. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2011) 'Profiling B-type natriuretic peptide in a stable heart failure population: A valuable adjunct to care'. Irish Journal of Medical Science, 180 (2):355-362. Available Online [DOI] [Details]
Arnous, S. and Murphy, N.F. and Pyne-Daly, P. and Nawoor, Z. and Keane, D. and Ledwidge, M. and McDonald, K. (2011) 'Clinical and psychological impact of prophylactic implantable cardioverter-defibrillators in a community heart failure population'. Irish Journal of Medical Science, 180 (2):369-374. Available Online [DOI] [Details]
Bermingham, M. and Ocallaghan, E. and Dawkins, I. and Miwa, S. and Samsudin, S. and McDonald, K. and Ledwidge, M. (2011) 'Are beta2-agonists responsible for increased mortality in heart failure?'. European Journal of Heart Failure, 13 (8):885-891. Available Online [DOI] [Details]
Arnous, S. and Killeen, R.P. and Martos, R. and Quinn, M. and McDonald, K. and Dodd, J.D. (2011) 'Quantification of mitral regurgitation on cardiac computed tomography: Comparison with qualitative and quantitative echocardiographic parameters'. Journal of Computer Assisted Tomography, 35 (5):625-630. Available Online [DOI] [Details]
Bermingham, M. and Hayden, J. and Dawkins, I. and Miwa, S. and Gibson, D. and McDonald, K. and Ledwidge, M. (2011) 'Prospective analysis of ldl-c goal achievement and self-reported medication adherence among statin users in primary care'. Clinical Therapeutics, 33 (9):1180-1189. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Voon, V. and Phelan, D. and Jan, A. and Mak, G. and Martos, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K.M. (2011) 'Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?'. European Journal of Heart Failure, 13 (10):1087-1095. Available Online [DOI] [Details]
Ryder, M. and Beattie, J.M. and O'Hanlon, R. and McDonald, K. (2011) 'Multidsciplinary heart failure management and end of life care'. Current Opinion in Supportive and Palliative Care, 5 (4):317-321. Available Online [DOI] [Details]
McDonald, K. and Dahlström, U. (2011) 'Natriuretic peptides - Addressing the dilemma of heart failure management'. European Cardiology, 7 (2):104-107. Available Online [Details]
Bermingham, M. and McDonald, K. and Ledwidge, M. (2011) 'The authors respond:'. Clinical Therapeutics, 33 (12). Available Online [DOI] [Details]
Watson, C.J. and Ledwidge, M.T. and Phelan, D. and Collier, P. and Byrne, J.C. and Dunn, M.J. and McDonald, K.M. and Baugh, J.A. (2011) 'Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure'. Circulation: Heart Failure, 4 (2):188-197. Available Online [DOI] [Details]
Conlon, C.M. and Dawkins, I. and O'Loughlin, C. and Gibson, D. and Kelleher, C.C. and Ledwidge, M. and McDonald, K. (2011) 'B-type natriuretic peptide measurement in primary care; Magnitude of associations with cardiovascular risk factors and their therapies. Observations from the STOP-HF (St. Vincent's Screening to Prevent Heart Failure) study'. Clinical Chemistry and Laboratory Medicine, 49 (4):719-728. Available Online [DOI] [Details]
Jan, A. and Murphy, N.F. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2011) 'Profiling B-type natriuretic peptide in a stable heart failure population: A valuable adjunct to care'. Irish Journal of Medical Science, 180 (2):355-362. Available Online [DOI] [Details]
Arnous, S. and Murphy, N.F. and Pyne-Daly, P. and Nawoor, Z. and Keane, D. and Ledwidge, M. and McDonald, K. (2011) 'Clinical and psychological impact of prophylactic implantable cardioverter-defibrillators in a community heart failure population'. Irish Journal of Medical Science, 180 (2):369-374. Available Online [DOI] [Details]
Bermingham, M. and Ocallaghan, E. and Dawkins, I. and Miwa, S. and Samsudin, S. and McDonald, K. and Ledwidge, M. (2011) 'Are beta2-agonists responsible for increased mortality in heart failure?'. European Journal of Heart Failure, 13 (8):885-891. Available Online [DOI] [Details]
Bermingham, M. and Hayden, J. and Dawkins, I. and Miwa, S. and Gibson, D. and McDonald, K. and Ledwidge, M. (2011) 'Prospective analysis of ldl-c goal achievement and self-reported medication adherence among statin users in primary care'. Clinical Therapeutics, 33 (9):1180-1189. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Voon, V. and Phelan, D. and Jan, A. and Mak, G. and Martos, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K.M. (2011) 'Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?'. European Journal of Heart Failure, 13 (10):1087-1095. Available Online [DOI] [Details]
McDonald K.; (2010) 'Disease management programs for heart failure'. Current treatment options in cardiovascular medicine, . [Details]
McDonald K.; (2010) 'Monitoring fluid status at the outpatient level: the need for more precision'. Congestive heart failure (Greenwich, Conn.), . [Details]