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Researchers at UCD

Kieran Sheahan

Associate Clinical Professor

School Of Medicine & Medical Science

Tel: +353 1 716
Email: kieran.sheahan@ucd.ie

Biography

Professor Kieran Sheahan: MB,BCh,.BAO B.Sc. M.R.C.P.I. F.R.C.P.I. F.F.Path .F.R.C.Path. is a Consultant Histopathologist & Head of Histopathology at the Department of Pathology, St. Vincent's University Hospital, Dublin & Associate Clinical Professor, University College Dublin School of Medicine & Medical Sciences. He graduated from UCD Medical School in 1981 & trained  in the Anatomic Pathology Program, Mallory Institute of Pathology, Boston, where he was Assistant Professor of  Pathology, Boston University  until 1992. He took up his present appointment in 1992 & became Associate Clinical Professor, UCD School of Medicine & Medical Sciences in 2007 He is a Director of the Centre for Colorectal Disease , SVUH. He is currently the Chair of the Histopathology sub-committee of the Faculty of Pathology, Royal College of Physicians of Ireland & chairs the Steering group of the National QA programme in Histopathology. He is a former Board Member of National Cancer Registry & President  of the Pathology Section, RAMI . He was the founding Treasurer of the Irish Society of Surgical Pathology.His research interests include Prognostic & predictive markers in colorectal cancer, familial gastrointestinal cancer, application of immunohistochemical & molecular genetic techniques in pathology & the pathobiology of inflammatory bowel disease. He has 72 original publications in peer-reviewed biomedical journals  place this text with a description of your biography, less than 500 words >>

Publications

     

Peer Reviewed Journals

Gremel, G., Ryan, D., Rafferty, M., Lanigan, F., Hegarty, S., Lavelle, M., Murphy, I., Unwin, L., Joyce, C., Faller, W., McDermott, E.W., Sheahan, K., Ponten, F.,Gallagher W.M. ; (2011) 'Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma'. British Journal of Cancer, 105 (4):565-574. [Details]
O'Riordan JM, O'Donoghue D, Green A, Keegan D, Hawkes LA, Payne SJ, Sheahan K, Winter DC; (2010) 'Hereditary mixed polyposis syndrome due to a BMPR1A mutation'. Colorectal Disease, 12 (6):570-573. [Details]
Shields CJ, Tiret E, Winter DC, Baum RP, Mortensen N, Fazio VW, Stocchi L, Sheahan K, O¿Keane C, Brannigan A, O¿Connell PR, Parc Y, Mourra N,Garcia-Olmo D, Soreide K, Prasad V, Kaemmerer D, Flemming M, Sagar P.; (2010) 'CARCINOID TUMOURS OF THE RECTUM ¿ A MULTI-INSTITUTIONAL INTERANTIONAL COLLABORATION'. Annals of Surgery, 252 :750-755. [Details]
Coss, A,Tose, M,Fox, EJ,Sapetto-Rebow, B,Gorman, S,Kennedy, BN,Lloyd, AT,Hyland, JM,O'Donoghue, DP,Sheahan, K,Leahy, DT,Mulcahy, HE,O'Sullivan, JN; (2009) 'Increased topoisomerase II alpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. Cancer, 276 :228-238. [DOI] [Details]
Canney, A,Sheahan, K,Keegan, D,Tolan, M,Hyland, J,Green, A; (2009) 'Synchronous lung tumours in a patient with metachronous colorectal carcinoma and a germline MSH2 mutation'. J Clin Pathol, 62 :471-473. [DOI] [Details]
Moloney, FJ, Hayden, J, Sheahan, K, Collins, P, ; (2007) 'Bilateral lower limb erythematous papules with myalgia'. CLIN EXP DERMATOL, 32 :475-476. [Details]
Cullen, G., O'Toole, A.,Keegan, D.,Sheahan, K.,Hyland, J. M., O'Donoghue D, P.; (2007) 'Long-term clinical results of ileocecal resection for Crohn's disease'. Inflammatory Bowel Diseases, 13 (11):1369-1373. [Details]
Sheahan, K, Fox, EJ, Keegan, D, Leahy, DT, Geraghty, R, Mulcahy, H, Green, A, Hyland, JM, O'Donoghue, DP, ; (2006) 'Molecular screening for HNPCC in an Irish population'. Gut, 55 (NA):85-85. [Details]
Geraghty, R, Leahy, D, Keegan, D, Mulcahy, H, O'Donoghue, D, Hyland, J, Sheahan, K, ; (2006) 'Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tuniors'. MODERN PATHOL, 19 (NA):59-59. [DOI] [Details]
Bakhiet, S, O'Sullivan, J, Izzuan, M, Keating, G, Gorman, J, Mulcahy, H, Hyland, J, O'Donoghue, D, Sheahan, K, ; (2006) 'GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers'. MODERN PATHOL, 19 (NA):55-55. [DOI] [Details]
Banville, N,Geraghty, R,Fox, E,Leahy, DT,Green, A,Keegan, D,Geoghegan, J,O'Donoghue, D,Hyland, J,Sheahan, K; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Human Pathology, 37 (11):1498-1502. [DOI] [Details]
Sheridan, J; Wang, LM; Fox, E; Dermot, L; Sheahan, K; Hyland, J; O'Donoghue, D; Mulcahy, H; O'Sullivan, J; ; (2006) 'Higher levels of oxidative damage and tumour infiltrating lymphocytes in non-metastatic versus metastatic colorectal tumours'. Modern Pathology, 19 (NA):70-70. [Details]
Sheridan, J; Wang, LM; Fox, E; Dermot, L; Sheahan, K; Hyland, J; O'Donoghue, D; Mulcahy, H; O'Sullivan, J; ; (2006) 'Higher levels of oxidative damage and tumour infiltrating lymphocytes in non-metastatic versus metastatic colorectal tumours'. Modern Pathology, 19 (NA):70-70. [Details]
Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, Sheahan K; (2006) 'Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O6-Methylguanine DNA Methyltransferase in Colorectal Cancer'. Journal of Molecular Diagnostics, 8 :68-75. [Details]
Bakhiet, S; O'Sullivan, J; Izzuan, M; Keating, G; Gorman, J; Mulcahy, H; Hyland, J; O'Donoghue, D; Sheahan, K; ; (2006) 'GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers'. Modern Pathology, 19 (NA):55-55. [Details]
Banville, N; Geraghty, R; Fox, E; Leahy, DT; Green, A; Keegan, D; Geoghegan, J; O'Donoghue, D; Hyland, J; Sheahan, K; ; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Human Pathology, 37 (11):1498-1502. [Details]
Sheahan, K; Fox, EJ; Keegan, D; Leahy, DT; Geraghty, R; Mulcahy, H; Green, A; Hyland, JM; O'Donoghue, DP; ; (2006) 'Molecular screening for HNPCC in an Irish population'. Gut, 55 (NA):85-85. [Details]
Fox, E. J.,Leahy, D. T.,Geraghty, R.,Mulcahy, H. E.,Fennelly, D.,Hyland, J. M.,O'Donoghue, D. P.,Sheahan, K.; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer'. J Mol Diagn, 8 (1):68-75. [Details]
Banville, N.,Geraghty, R.,Fox, E.,Leahy, D. T.,Green, A.,Keegan, D.,Geoghegan, J.,O'Donoghue, D.,Hyland, J.,Sheahan, K.; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Hum Pathol, 37 (11):1498-502. [Details]
Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, Sheahan K; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and 06-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Kavanagh ,Neary P, Dodd J, Sheahan K, O'Donoghue DP, Hyland JMP.; (2006) 'Management of enterovesical fistula in a Colorectal unit'. Technical Coloproctology, 10 (1):63-64. [Details]
Banville, N.,Geraghty, R.,Fox, E.,Leahy, D. T.,Green, A.,Keegan, D.,Geoghegan, J.,O'Donoghue, D.,Hyland, J.,Sheahan, K.; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Human Pathology, 37 (11):1498-502. [Details]
Sheahan K, Fox EJ, Leahy DT, Geraghty R, Mulcahy HE, Fennelly D, Hyland JM, O'Donoghue DP, ; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Hyland JM, Kavanagh DO, Neary P, Dodd JD, Sheahan K, O'Donoghue D, ; (2006) 'Management of enterovaginal fistulae in a colorectal unit'. Techniques in coloproctology, 1 (NA):63-64. [Details]
Bakheit, S; Dolan, J; O'Sullivan, J; Keating, G; Gorman, J; Mulcahy, H; Hyland, J; O'Donoghue, D; Sheahan, K; ; (2005) 'Glucose transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia'. Modern Pathology, 18 (NA):97-98. [Details]
Troy AM, Sheahan K, Mulcahy HE, Duffy MJ, Hyland JM, O'Donoghue DP; (2004) 'Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression'. European journal of cancer (Oxford, England : 1990), 40 (10):1610-1616. [DOI] [Details]
O'Keeffe, J,Doherty, DG,Kenna, T,Sheahan, K,O'Donoghue, DP,Hyland, JM,O'Farrelly, C; (2004) 'Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer'. European Journal of Immunology, 34 :2110-2118. [DOI] [Details]
R Mofidi, R., Neary, P., Brabazon, A., White, A., Ryan, R., Sheahan, K. ODonoghue, D. & Hyland, J; (2003) 'Prediction of Local Recurrence from Rectal Carcinoma Using an Artificial Neural Network'. Colorectal Disease, 5 (2). [Details]
Mofidi, R., Connolly, S., Neary, P., Brabazon, A., Ryan, R.E., Stone, J.E., Sheahan, K., Geoghegan, J.G. & Traynor, O.; (2002) 'Prediction of outcome in hepatic resection for metastatic colorectal carcinoma'. British Journal of Surgery, 89 (5):669-669. [Details]
McCormack, G; Moriarty, D; O'Donoghue, DP; McCormick, PA; Sheahan, K; Baird, AW; ; (2001) 'Tissue cytokine and chemokine expression in inflammatory bowel disease'. Inflammation Research, 50 (10):491-495. [Details]
Moriarty, DV; O'Riordan, A; O'Donoghue, DP; Hyland, J; Sheahan, K; Baird, AW; ; (2000) 'Substance P release and modulation of human colonic ion transport: Alterations during IBD'. Gastroenterology, 118 (4):1105-1105. [Details]
Sheehan, K. M.,Sheahan, K.,O'Donoghue, D. P.,MacSweeney, F.,Conroy, R. M.,Fitzgerald, D. J.,Murray, F. E.; (1999) 'The relationship between cyclooxygenase-2 expression and colorectal cancer'. Jama, 282 (13):1254-7. [Details]
O'Higgins NJ, O'Keeffe DA, Hill AD, Sheahan K, Ryan F, Barton D, Fitzgerald RJ, McDermott EW, ; (1998) 'Ret-proto-oncogene analysis in medullary thyroid carcinoma'. Irish Journal of Medical Science, 167 (4):226-230. [Details]
Brady, HR; Harrington, JT; Garrett, P; Donohoe, J; O'Meara, Y; Keogh, BA; Fitzpatrick, JM; Sheahan, K; Dorman, A; Gaffney, E; Murnaghan, D; Cottell, DC; Mellotte, G; Muldowney, FP; ; (1998) 'Fibrillary glomerulopathy'. Kidney International, 53 (5):1421-1429. [Details]
Brady, HR; Harrington, JT; Garrett, P; Donohoe, J; O'Meara, Y; Keogh, BA; Fitzpatrick, JM; Sheahan, K; Dorman, A; Gaffney, E; Murnaghan, D; Cottell, DC; Mellotte, G; Muldowney, FP; ; (1998) 'Fibrillary glomerulopathy'. Kidney International, 53 (5):1421-1429. [Details]
O'Keeffe, DA,Hill, ADK,Sheahan, K,Ryan, F,Barton, D,Fitzgerald, RJ,McDermott, EW,O'Higgins, NJ; (1998) 'Ret-proto-oncogene analysis in medullary thyroid carcinoma'. IRISH J MED SCI, 167 :226-230. [Details]
Moriarty, D; Ettarh, R; Sheahan, K; Hyland, J; O'Donoghue, DP; Baird, AW; ; (1998) 'Structural associations between mast cells and enteric nerves in normal and inflamed human colon'. Gastroenterology, 114 (4):400-400. [Details]
Skelly MM, Troy A, Duffy MJ, Mulcahy HE, Duggan C, Connell TG, O'Donoghue DP, Sheahan K; (1997) 'Urokinase-type plasminogen activator in colorectal cancer: relationship with clinicopathological features and patient outcome'. Clinical cancer research : an official journal of the American Association for Cancer Research, 3 (10):1837-1840. [Details]
Leahy DT, Salman R, Mulcahy H, Sheahan K, O'Donoghue DP, Parfrey NA.; (1996) 'Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCR-SSCP and immunohistochemical analysis'. Journal of Pathology, 180 (4):364-370. [Details]
Sheahan K, Mulcahy HE, Duffy MJ, Gibbons D, McCarthy P, Parfrey NA, O'Donoghue DP, ; (1994) 'Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer'. Lancet, 344 (8922):583-584. [Details]

Other Journals

Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) 'Fibulin-1 and-4 mRNA expression levels in human colorectal cancer' British Journal of Cancer 91 (NA) :70-70. [Details]

Conference Publications

Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) LABORATORY INVESTIGATION 90: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) MODERN PATHOLOGY 23: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
Leahy DT, Milewski M, Fox E, Geraghty R, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2009) MODERN PATHOLOGY 22: Suppl. 1, 137 Role of E-Cadherin and Beta-Catenin in Colorectal Cancer Progression [Details]
Sheahan, K; Fox, EJ; Keegan, D; Leahy, DT; Geraghty, R; Mulcahy, H; Green, A; Hyland, JM; O'Donoghue, DP; ; (2006) GUT 55: Suppl. 2, A85 Molecular screening for HNPCC in an Irish population [Details]
Geraghty, R; Leahy, D; Keegan, D; Mulcahy, H; O'Donoghue, D; Hyland, J; Sheahan, K; ; (2006) MODERN PATHOLOGY 19: Suppl. 3, 60 Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tumors [Details]
Fox, EJ; Leahy, DT; Geraghty, R; Lennon, AM; Keegan, D; White, A; Mulcahy, HE; Hyland, JM; Fennelly, D; O'Donoghue, DP; Sheahan, K; ; (2005) LABORATORY INVESTIGATION 85: Suppl. 1, 102A Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers [Details]
Fox, EJ; Leahy, DT; Geraghty, R; Lennon, AM; Keegan, D; White, A; Mulcahy, HE; Hyland, JM; Fennelly, D; O'Donoghue, DP; Sheahan, K; ; (2005) MODERN PATHOLOGY 18: Suppl. 1, 102A Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers [Details]
Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) BRITISH JOURNAL OF CANCER 91: Suppl. 1, S70 Fibulin-1 and-4 mRNA expression levels in human colorectal cancer [Details]
   

Editorial

Cleary, M,Coss, A,Sheahan, K,Mulcahy, H,Hyland, J; (2004) Dieulafoy's lesion in a Meckel's diverticulum. Editorial [Details]
Brady, HR,Harrington, JT,Garrett, P,Donohoe, J,O'Meara, Y,Keogh, BA,Fitzpatrick, JM,Sheahan, K,Dorman, A,Gaffney, E,Murnaghan, D,Cottell, DC,Mellotte, G,Muldowney, FP; (1998) Fibrillary glomerulopathy. Editorial [Details]
                 

Abstract

Lecka-Czernik, B., Greene, L. M., Sheahan, K., O Donoghue, D. P., and Gallagher, W. M.; (2002) S2-6, a novel marker for cancer detection and candidate tumor suppressor gene. Abstract [Details]
                                                               

Research

Research Interests

Research Projects

Sponsor : Health Research Board (HRB)
Title : Molecular analysis of colorectal cancer: it's role in detecting familial cancer and predicting response to chemotherapy
Start Date / End Date : 01-OCT-01 / 30-SEP-04
Sponsor : Health Research Board (HRB)
Title : Molecular characterisation of familial colorectal cancers
Start Date / End Date : 01-OCT-06 / 19-DEC-10