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Researchers at UCD

researcher

Martin Steinhoff

Professorial Chair of Dermatology and Director Ucd Charles Institute of Dermatology

School of Medicine & Medical Science
F004
UCD Charles Institute
UCD, Belfield, Dublin 4
Ireland

Tel: 01-716 6261
Email: martin.steinhoff@ucd.ie

Professional

Honours and Awards

Year: 1992.
Title: M.Sc. in Human Biology: Grade A (1.0) with excellence
Year: 2001.
Title: Oskar-Gans main scientific award (Work on protease-activated receptors)
Year: 2001.
Title: Summa cum laude (Faculty Best Thesis Award), Ph.D. in Human Biology
Year: 2004.
Title: Paul Langerhans-Research-Award
Year: 2005.
Title: Victor-Bruhns Award
Year: 2013.
Title: Appreciation award of National Rosacea Society to improve lives of patients with rosacea
Year: 2014.
Title: Innovation Research Award
 

Patents

Patent 14/129,809 : TH-17 differentiation markers for rosacea and uses thereof
Patent WO2010/007175 : PACAP signaling pathway modulators for treating inflammatory skin diseases with a neurogenic component, and more particularly rosacea and composition containing them
Patent OA10307 : Markers and Methods for the diagnosis of Rosacea
       

Employment

Employer: University of Marburg
Position: Postgraduate clinical training
Employer: University of Goettingen
Position: Resident
Employer: University of California San Francisco
Position: Post doc (MD) and PhD thesis
Employer: University of Muenster
Position: Resident; Scientific University Assistant
Employer: University of Muenster
Position: Assistant Professor of Dermatology, Venerology, Allergy, Phlebology
Employer: University of Muenster
Position: Assoc-Professor of Dermatology, Venerology, Allergy, Phlebology
Employer: University of California, San Francisco
Position: Full Professor in- Residence, Step 2
Employer: University College Dublin
Position: Professorial Chair of Dermatology and Director of Charles Institute of Dermatology

Education

Year 1995 Institution: University of Marburg, Germany
Qualification: Other Subject:
Year 2003 Institution: Medical Board Muenster, Germany
Qualification: Other Subject:
Year 2004 Institution: Medical Board Muenster, Germany
Qualification: Other Subject:
Year 2013 Institution: Medical Board of California, USA
Qualification: Other Subject:
Year 2002 Institution: Medical Board Muenster, Germany
Qualification: Other Subject:
Year 1986 Institution: University of Braunschweig, Germany
Qualification: Other Subject:
Year 1992 Institution: University of Marburg, Germany
Qualification: Other Subject:
Year 2001 Institution: University of Marburg, Germany
Qualification: Other Subject:
         

Publications

 

Book Chapters

Cevikbas, F., Kempkes, C., Buhl, T., Mess, C., Buddenkotte, J., Steinhoff, M., Carstens, E., Akiyama, T. (2014) 'Role of Interleukin-31 and Oncostatin M in Itch and Neuroimmune Communication' In: Itch: Mechanisms and Treatment. Available Online [Details]
 

Peer Reviewed Journals

Lozano JM, Steinhoff M, Ruiz JG, Mesa ML, Martinez N, Dussan B (1994) 'Clinical predictors of acute radiological pneumonia and hypoxaemia at high altitude'. Archives of Disease in Childhood, 71 (4):323-327. [Details]
Treleaven S, Steinhoff M, Biggs BA, Rerks-Ngarm S (2005) 'A reply to the Letter to the Editor by Mäkelä, Herva and Nohynek in response to the article by Rerks-Ngarm S, Treleaven SC, Chunsuttiwat S, Muangchana C, Jolley D, Brooks A, Dejsirilert S, Warintrawat S, Guiver M, Kunasol P, Maynard JE, Biggs B-A, Steinhoff M. Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand. Vaccine 2004;22:975-83'. Vaccine, 23 (46-47):5284-5285. [DOI] [Details]
Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J, Steinhoff M, Hoffmann TK, Ruzicka T, Zlotnik A, Homey B (2006) 'IL-31: a new link between T cells and pruritus in atopic skin inflammation'. Clinical Immunology, 117 (2):411-417. [DOI] [Details]
Obreja O, Rukwied R, Steinhoff M, Schmelz M (2006) 'Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo'. Experimental Dermatology, 15 (1):58-65. [DOI] [Details]
Assaf C, Gellrich S, Steinhoff M, Nashan D, Weisse F, Dippel E, Coors E, Stein A, Gollin P, Henke U, Adam-Murati S, Koch A, Klemke CD, Stadler R, Sterry W (2007) 'Cutaneous lymphomas in Germany: an analysis of the Central Cutaneous Lymphoma Registry of the German Society of Dermatology (DDG)'. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 5 (8):662-668. [DOI] [Details]
Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady EF, Bunnett NW (2007) 'Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1'. Journal of Biological Chemistry, 282 (16):12260-12271. [DOI] [Details]
Maza S, Gellrich S, Assaf C, Beyer M, Spilker L, Orawa H, Munz DL, Sterry W, Steinhoff M (2008) 'Yttrium-90 ibritumomab tiuxetan radioimmunotherapy in primary cutaneous B-cell lymphomas: first results of a prospective, monocentre study'. Leukemia & lymphoma, 49 (9):1702-1709. [DOI] [Details]
Hyun E, Andrade-Gordon P, Steinhoff M, Vergnolle N (2008) 'Protease-activated receptor-2 activation: a major actor in intestinal inflammation'. Gut, 57 (9):1222-1229. [DOI] [Details]
Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M (2014) 'A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1'. Clinical Immunology, 133 (2):448-460. [DOI] [Details]
Aumuller, G., Groschel-Stewart, U., Altmannsberger, M., Mannherz, H.G., Steinhoff, M. (1991) 'Basal cells of H-Dunning tumor are myoepithelial cells. A comparative immunohistochemical and ultrastructural study with male accessory sex glands and mammary gland'. Histochemistry, 95 (4):341-349. Available Online [Details]
Goebel, H.-W., Rausch, U., Steinhoff, M., Seitz, J., Bacher, M., Papotti, M., Bussolati, G., Tuohimaa, P., Aumuller, G. (1992) 'Arguments against the prostatic origin of the R-3327 Dunning H tumor'. Virchows Archiv - B Cell Pathology Including Molecular Pathology, 62 (1):9-18. Available Online [Details]
Steinhoff, M., Eicheler, W., Holterhus, P.M., Rausch, U., Seitz, J., Aumuller, G. (1994) 'Hormonally induced changes in apocrine secretion of transglutaminase in the rat dorsal prostate and coagulating gland'. European Journal of Cell Biology, 65 (1):49-59. Available Online [Details]
Eicheler, W., Seitz, J., Steinhoff, M., Forssmann, W. G., Adermann, K., Aumuller, G. (1995) 'Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry'. Exp Clin Endocrinol Diabetes, 103 (2):105-12. Available Online [Details]
Quinlan, K. L., Song, I. S., Bunnett, N. W., Letran, E., Steinhoff, M., Harten, B., Olerud, J. E., Armstrong, C. A., Wright Caughman, S., Ansel, J. C. (1998) 'Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function'. Am J Physiol, 275 (6 Pt 1). Available Online [Details]
Nguyen, T.D., Moody, M.W., Steinhoff, M., Okolo, C., Koh, D.-S., Bunnett, N.W. (1999) 'Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2'. Journal of Clinical Investigation, 103 (2):261-269. Available Online [Details]
Steinhoff, M., McGregor, G.P., Radleff-Schlimme, A., Steinhoff, A., Jarry, H., Schmidt, W.E. (1999) 'Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: Expression of PACAP-38 is increased in patients with psoriasis'. Regulatory Peptides, 80 (1-2):49-55. Available Online [Details]
Steinhoff, M., Corvera, C.U., Thoma, M.S., Kong, W., McAlpine, B.E., Caughey, G.H., Ansel, J.C., Bunnett, N.W. (1999) 'Proteinase-activated receptor-2 in human skin: Tissue distribution and activation of keratinocytes by mast cell tryptase'. Experimental Dermatology, 8 (4):282-294. Available Online [Details]
Bertog, M., Letz, B., Kong, W., Steinhoff, M., Higgins, M.A., Bielfeld-Ackermann, A., Frömter, E., Bunnett, N.W., Korbmacher, C. (1999) 'Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells'. Journal of Physiology, 521 (1):3-17. Available Online [Details]
Fang, K. C., Wolters, P. J., Steinhoff, M., Bidgol, A., Blount, J. L., Caughey, G. H. (1999) 'Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta'. J Immunol, 162 (9):5528-35. Available Online [Details]
Steinhoff, M., Corvera, C. U., Thoma, M. S., Kong, W., McAlpine, B. E., Caughey, G. H., Ansel, J. C., Bunnett, N. W. (1999) 'Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase'. Exp Dermatol, 8 (4):282-94. Available Online [Details]
Steinhoff, M., McGregor, G. P., Radleff-Schlimme, A., Steinhoff, A., Jarry, H., Schmidt, W. E. (1999) 'Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis'. Regul Pept, 80 (1-2):49-55. Available Online [Details]
Steinhoff, M., Meinhardt, A., Steinhoff, A., Gemsa, D., Bucala, R., Bacher, M. (1999) 'Evidence for a role of macrophage migration inhibitory factor in psoriatic skin disease'. British Journal of Dermatology, 141 (6):1061-1066. Available Online [Details]
Song, I.-S., Bunnett, N.W., Olerud, J.E., Harten, B., Steinhoff, M., Brown, J.R., Sung, K.J., Armstrong, C.A., Ansel, J.C. (2000) 'Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R)'. Experimental Dermatology, 9 (1):42-52. Available Online [Details]
Steinhoff, M., Vergnolle, N., Young, S.H., Tognetto, M., Amadesi, S., Ennes, H.S., Trevisani, M., Hollenberg, M.D., Wallace, J.L., Caughey, G.H., Mitchell, S.E., Williams, L.M., Geppetti, P., Mayer, E.A., Bunnett, N.W. (2000) 'Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism'. Nature Medicine, 6 (2):151-158. Available Online [Details]
Ricciardolo, F.L.M., Steinhoff, M., Amadesi, S., Guerrini, R., Tognetto, M., Trevisani, M., Creminon, C., Bertrand, C., Bunnett, N.W., Fabbri, L.M., Salvadori, S., Geppetti, P. (2000) 'Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways'. American Journal of Respiratory and Critical Care Medicine, 161 (5):1672-1680. Available Online [Details]
Ricciardolo, F. L., Steinhoff, M., Amadesi, S., Guerrini, R., Tognetto, M., Trevisani, M., Creminon, C., Bertrand, C., Bunnett, N. W., Fabbri, L. M., Salvadori, S., Geppetti, P. (2000) 'Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways'. Am J Respir Crit Care Med, 161 (5):1672-80. Available Online [Details]
Green, B.T., Bunnett, N.W., Kulkarni-Narla, A., Steinhoff, M., Brown, D.R. (2000) 'Intestinal type 2 proteinase-activated receptors: Expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport'. Journal of Pharmacology and Experimental Therapeutics, 295 (1):410-416. Available Online [Details]
Scholzen, T.E., Steinhoff, M., Bonaccorsi, P., Klein, R., Amadesi, S., Geppetti, P., Lu, B., Gerard, N.P., Olerud, J.E., Luger, T.A., Bunnett, N.W., Grady, E.F., Armstrong, C.A., Ansel, J.C. (2001) 'Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis'. Journal of Immunology, 166 (2):1285-1291. Available Online [Details]
Steinhoff, M., Hesse, H., Göke, B., Steinhoff, A., Eissele, R., Slater, E.P. (2001) 'Indirect RT-PCR in-situ hybridization: A novel non-radioactive method for detecting glucose-dependent insulinotropic peptide'. Regulatory Peptides, 97 (2-3):187-194. Available Online [Details]
De Garavilla, L., Vergnolle, N., Young, S.H., Ennes, H., Steinhoff, M., Ossovskaya, V.S., D'Andrea, M.R., Mayer, E.A., Wallace, J.L., Hollenberg, M.D., Andrade-Gordon, P., Bunnett, N.W. (2001) 'Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism'. British Journal of Pharmacology, 133 (7):975-987. Available Online [Details]
Steinhoff, M., Brzoska, T., Luger, T.A. (2001) 'Keratinocytes in epidermal immune responses'. Current opinion in allergy and clinical immunology, 1 (5):469-476. Available Online [Details]
Steinhoff, M., Metze, D., Stockfleth, E., Luger, T. A. (2001) 'Successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta'. The British journal of dermatology, 144 (5):1067-9. Available Online [Details]
Steinhoff, M., Metze, D., Stockfleth, E., Luger, T.A. (2001) 'Pustular psoriasis of the nails: Treatment and long-term follow-up of 46 patients'. British Journal of Dermatology, 144 (5):1000-1005. Available Online [Details]
Ständer, S., Steinhoff, M. (2002) 'Pathophysiology of pruritus in atopic dermatitis: An overview'. Experimental Dermatology, 11 (1):12-24. Available Online [Details]
Vergnolle, N., Derian, C.K., D'Andrea, M.R., Steinhoff, M., Andrade-Gordon, P. (2002) 'Characterization of thrombin-induced leukocyte rolling and adherence: A potential proinflammatory role for proteinase-activated receptor-4'. Journal of Immunology, 169 (3):1467-1473. Available Online [Details]
Shpacovitch, V. M., Brzoska, T., Buddenkotte, J., Stroh, C., Sommerhoff, C. P., Ansel, J. C., Schulze-Osthoff, K., Bunnett, N. W., Luger, T. A., Steinhoff, M. (2002) 'Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells'. J Invest Dermatol, 118 (2):380-5. Available Online [Details]
Stander, S., Gunzer, M., Metze, D., Luger, T., Steinhoff, M. (2002) 'Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin'. Regul Pept, 110 (1):75-83. Available Online [Details]
Ständer, S., Weisshaar, E., Steinhoff, M., Luger, T.A., Metze, D. (2003) 'Pruritus-pathophysiology, clinical features and therapy - An overview [Pruritus-pathophysiologie, klinik und therapie - Eine übersicht]'. JDDG - Journal of the German Society of Dermatology, 1 (2):105-118. Available Online [Details]
Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P.S., Luger, T.A., Schmelz, M. (2003) 'Proteinase-activated receptor-2 mediates itch: A novel pathway for pruritus in human skin'. Journal of Neuroscience, 23 (15):6176-6180. Available Online [Details]
Rattenholl, A., Steinhoff, M. (2003) 'Role of proteinase-activated receptors in cutaneous biology and disease'. Drug Development Research, 59 (4):408-416. Available Online [Details]
Vergnolle, N., Ferazzini, M., D'Andrea, M.R., Buddenkotte, J., Steinhoff, M. (2003) 'Proteinase-activated receptors: Novel signals for peripheral nerves'. Trends in Neurosciences, 26 (9):496-500. Available Online [Details]
Nguyen, C., Coelho, A.-M., Grady, E., Compton, S.J., Wallace, J.L., Hollenberg, M.D., Cenac, N., Garcia-Villar, R., Bueno, L., Steinhoff, M., Bunnett, N.W., Vergnolle, N. (2003) 'Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism'. Canadian Journal of Physiology and Pharmacology, 81 (9):920-927. Available Online [Details]
Seeliger, S., Derian, C.K., Vergnolle, N., Bunnett, N.W., Nawroth, R., Schmelz, M., Von der Weid, P.-Y., Buddenkotte, J., Sunderkötter, C., Metze, D., Andrade-Gordon, P., Harms, E., Vestweber, D., Luger, T.A., Steinhoff, M. (2003) 'Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo'. FASEB Journal, 17 (13):1871-1885. Available Online [Details]
Ständer, S., Steinhoff, M., Schmelz, M., Weisshaar, E., Metze, D., Luger, T. (2003) 'Neurophysiology of Pruritus: Cutaneous Elicitation of Itch'. Archives of Dermatology, 139 (11):1463-1470. Available Online [Details]
Ikoma, A., Rukwied, R., Ständer, S., Steinhoff, M., Miyachi, Y., Schmelz, M. (2003) 'Neuronal Sensitization for Histamine-Induced Itch in Lesional Skin of Patients with Atopic Dermatitis'. Archives of Dermatology, 139 (11):1455-1458. Available Online [Details]
Ikoma, A., Rukwied, R., Ständer, S., Steinhoff, M., Miyachi, Y., Schmelz, M. (2003) 'Neurophysiology of Pruritus: Interaction of Itch and Pain'. Archives of Dermatology, 139 (11):1475-1478. Available Online [Details]
Ikoma, A., Rukwied, R., Stander, S., Steinhoff, M., Miyachi, Y., Schmelz, M. (2003) 'Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis'. Archives of dermatology, 139 (11):1455-8. Available Online [Details]
Steinhoff, M., Ständer, S., Seeliger, S., Ansel, J.C., Schmelz, M., Luger, T. (2003) 'Modern Aspects of Cutaneous Neurogenic Inflammation'. Archives of Dermatology, 139 (11):1479-1488. Available Online [Details]
Ständer, S., Moormann, C., Schumacher, M., Buddenkotte, J., Artuc, M., Shpacovitch, V., Brzoska, T., Lippert, U., Henz, B.M., Luger, T.A., Metze, D., Steinhoff, M. (2004) 'Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures'. Experimental Dermatology, 13 (3):129-139. Available Online [Details]
Scholzen, T.E., Steinhoff, M., Sindrilaru, A., Schwarz, A., Bunnett, N.W., Luger, T.A., Armstrong, C.A., Ansel, J.C. (2004) 'Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage'. FASEB Journal, 18 (9):1007-1009. Available Online [Details]
Roosterman, D., Cottrell, G.S., Schmidlin, F., Steinhoff, M., Bunnett, N.W. (2004) 'Recycling and resensitization of the neurokinin 1 receptor: Influence of agonist concentration and Rab GTPases'. Journal of Biological Chemistry, 279 (29):30670-30679. Available Online [Details]
Shpacovitch, V.M., Varga, G., Strey, A., Gunzer, M., Mooren, F., Buddenkotte, J., Vergnolle, N., Sommerhoff, C.P., Grabbe, S., Gerke, V., Homey, B., Hollenberg, M., Luger, T.A., Steinhoff, M. (2004) 'Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices'. Journal of Leukocyte Biology, 76 (2):388-398. Available Online [Details]
Hyun, E., Bolla, M., Steinhoff, M., Wallace, J.L., Del Soldato, P., Vergnolle, N. (2004) 'Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis'. British Journal of Pharmacology, 143 (5):618-625. Available Online [Details]
Vergnolle, N., Cellars, L., Mencarelli, A., Rizzo, G., Swaminathan, S., Beck, P., Steinhoff, M., Andrade-Gordon, P., Bunnett, N.W., Hollenberg, M.D., Wallace, J.L., Cirino, G., Fiorucci, S. (2004) 'A role for proteinase-activated receptor-1 in inflammatory bowel diseases'. Journal of Clinical Investigation, 114 (10):1444-1456. Available Online [Details]
Hyun, E., Bolla, M., Steinhoff, M., Wallace, J. L., Soldato, P. D., Vergnolle, N. (2004) 'Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis'. Br J Pharmacol, 143 (5):618-25. Available Online [Details]
Roosterman, D., Cottrell, G. S., Schmidlin, F., Steinhoff, M., Bunnett, N. W. (2004) 'Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases'. J Biol Chem, 279 (29):30670-9. Available Online [Details]
Stander, S., Moormann, C., Schumacher, M., Buddenkotte, J., Artuc, M., Shpacovitch, V., Brzoska, T., Lippert, U., Henz, B. M., Luger, T. A., Metze, D., Steinhoff, M. (2004) 'Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures'. Exp Dermatol, 13 (3):129-39. Available Online [Details]
Grassberger, M., Steinhoff, M., Schneider, D., Luger, T.A. (2004) 'Pimecrolimus - An anti-inflammatory drug targeting the skin'. Experimental Dermatology, 13 (12):721-730. Available Online [Details]
Buddenkotte, J., Stroh, C., Engels, I.H., Moormann, C., Shpacovitch, V.M., Seeliger, S., Vergnolle, N., Vestweber, D., Luger, T.A., Schulze-Osthoff, K., Steinhoff, M. (2005) 'Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B'. Journal of Investigative Dermatology, 124 (1):38-45. Available Online [Details]
Hensen, P., Fürstenberg, T., Luger, T.A., Steinhoff, M., Roeder, N. (2005) 'Case mix measures and diagnosis-related groups: Opportunities and threats for inpatient dermatology'. Journal of the European Academy of Dermatology and Venereology, 19 (5):582-588. Available Online [Details]
Cenac, N., Cellars, L., Steinhoff, M., Andrade-Gordon, P., Hollenberg, M.D., Wallace, J.L., Fiorucci, S., Vergnolle, N. (2005) 'Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response'. Inflammatory Bowel Diseases, 11 (9):792-798. Available Online [Details]
Goerge, T., Schneider, S.W., Steinhoff, M. (2005) 'Atopic dermatitis: Pathophysiological background, scientific status quo and therapeutic strategies [Atopische dermatitis: Pathophysiologischer hintergrund, wissenschaftlicher status quo und therapeutische strategien]'. Medizinische Monatsschrift fur Pharmazeuten, 28 (8):267-276. Available Online [Details]
Bíró, T., Ko, M.C., Bromm, B., Wei, E.T., Bigliardi, P., Siebenhaar, F., Hashizume, H., Misery, L., Bergasa, N.V., Kamei, C., Schouenborg, J., Roostermann, D., Szabó, T., Maurer, M., Bigliardi-Qi, M., Meingassner, J.G., Hossen, M.A., Schmelz, M., Steinhoff, M. (2005) 'How best to fight that nasty itch - From new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches'. Experimental Dermatology, 14 (3):225-240. Available Online [Details]
Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T.A., Hollenberg, M.D. (2005) 'Proteinase-activated receptors: Transducers of proteinase-mediated signaling in inflammation and immune response'. Endocrine Reviews, 26 (1):1-43. Available Online [Details]
Ikoma, A., Steinhoff, M., Ständer, S., Yosipovitch, G., Schmelz, M. (2006) 'The neurobiology of itch'. Nature Reviews Neuroscience, 7 (7):535-547. Available Online [Details]
Vergnolle, N., Cellars, L., Mencarelli, A., Rizzo, G., Swaminathan, S., Beck, P., Steinhoff, M., Andrade-Gordon, P., Bunnett, N.W., Hollenberg, M.D., Wallace, J.L., Cirino, G., Fiorucci, S. (2006) 'A role for proteinase-activated receptor-1 in inflammatory bowel diseases'. The Journal of clinical investigation, 116 (7). Available Online [Details]
Holzhausen, M., Spolidorio, L.C., Ellen, R.P., Jobin, M.-C., Steinhoff, M., Andrade-Gordon, P., Vergnolle, N. (2006) 'Protease-activated receptor-2 activation: A major role in the pathogenesis of Porphyromonas gingivalis infection'. American Journal of Pathology, 168 (4):1189-1199. Available Online [Details]
Moormann, C., Artuc, M., Pohl, E., Varga, G., Buddenkotte, J., Vergnolle, N., Brehler, R., Henz, B.M., Schneider, S.W., Luger, T.A., Steinhoff, M. (2006) 'Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells'. Journal of Investigative Dermatology, 126 (4):746-755. Available Online [Details]
Iosub, R., Klug, J., Schneider, E., Fröhlich, S., Blumbach, K., Wennemuth, G., Sommerhoff, C.P., Steinhoff, M., Meinhardt, A. (2006) 'Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2'. Journal of Pathology, 208 (5):686-698. Available Online [Details]
Homey, B., Steinhoff, M., Ruzicka, T., Leung, D.Y.M. (2006) 'Cytokines and chemokines orchestrate atopic skin inflammation'. Journal of Allergy and Clinical Immunology, 118 (1):178-189. Available Online [Details]
Paus, R., Schmelz, M., Bíró, T., Steinhoff, M. (2006) 'Frontiers in pruritus research: Scratching the brain for more effective itch therapy'. Journal of Clinical Investigation, 116 (5):1174-1185. Available Online [Details]
Sonkoly, E., Muller, A., Lauerma, A.I., Pivarcsi, A., Soto, H., Kemeny, L., Alenius, H., Dieu-Nosjean, M.-C., Meller, S., Rieker, J., Steinhoff, M., Hoffmann, T.K., Ruzicka, T., Zlotnik, A., Homey, B. (2006) 'IL-31: A new link between T cells and pruritus in atopic skin inflammation'. Journal of Allergy and Clinical Immunology, 117 (2):411-417. Available Online [Details]
Obreja, O., Rukwied, R., Steinhoff, M., Schmelz, M. (2006) 'Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo'. Experimental Dermatology, 15 (1):58-65. Available Online [Details]
Steinhoff, M. (2006) 'Molecular mechanisms of cutaneous neurogenic inflammation and pruritus [Molekulare mechanismen der kutanen neurogenen entzündung und des juckreizes]'. Aktuelle Dermatologie, 32 (11):463-467. Available Online [Details]
Roosterman, D., Goerge, T., Schneider, S.W., Bunnett, N.W., Steinhoff, M. (2006) 'Neuronal control of skin function: The skin as a neuroimmunoendocrine organ'. Physiological Reviews, 86 (4):1309-1379. Available Online [Details]
Cottrell, G.S., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Gehringer, D., Grady, E.F., Bunnett, N.W. (2006) 'Ubiquitin-dependent down-regulation of the neurokinin-1 receptor'. Journal of Biological Chemistry, 281 (38):27773-27783. Available Online [Details]
Steinhoff, M., Bienenstock, J., Schmelz, M., Maurer, M., Wei, E., Bíró, T. (2006) 'Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus'. Journal of Investigative Dermatology, 126 (8):1705-1718. Available Online [Details]
Goerge, T., Barg, A., Schnaeker, E.-M., Poppelmann, B., Shpacovitch, V., Rattenholl, A., Maaser, C., Luger, T.A., Steinhoff, M., Schneider, S.W. (2006) 'Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation'. Cancer Research, 66 (15):7766-7774. Available Online [Details]
Vergnolle, N., Cellars, L., Mencarelli, A., Rizzo, G., Swaminathan, S., Beck, P., Steinhoff, M., Andrade-Gordon, P., Bunnett, N.W., Hollenberg, M.D., Wallace, J.L., Cirino, G., Fiorucci, S. (2006) 'Erratum (Retracted article): A role for proteinase-activated receptor-1 in inflammatory bowel diseases (Journal of Clinical Investigation (2004) 114 (1444-1456) DOI:10.1172/JCI200421689)'. Journal of Clinical Investigation, 116 (7). Available Online [Details]
Emmert, S., Steinhoff, M., Gunzl, H. J., Runger, T. M. (2006) '[Persistent plaque on the back and right upper arm. Latent syphilis (lues III) with tubero-ulcero-serpiginous plaque]'. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 4 (2):156-9. Available Online [Details]
Steinhoff, M., Steinhoff, A., Homey, B., Luger, T.A., Schneider, S.W. (2006) 'Role of vasculature in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 118 (1):190-197. Available Online [Details]
Ständer, S., Ständer, H., Seeliger, S., Luger, T.A., Steinhoff, M. (2007) 'Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin'. British Journal of Dermatology, 156 (5):1020-1026. Available Online [Details]
Kindt, F., Wiegand, S., Löser, C., Nilles, M., Niemeier, V., Hsu, S.Y.T., Steinhoff, M., Kummer, W., Gieler, U., Haberberger, R.V. (2007) 'Intermedin: A skin peptide that is downregulated in atopic dermatitis'. Journal of Investigative Dermatology, 127 (3):605-613. Available Online [Details]
Cenac, N., Andrews, C.N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N.W., Sharkey, K.A., Ferraz, J.G.P., Shaffer, E., Vergnolle, N. (2007) 'Role for protease activity in visceral pain in irritable bowel syndrome'. Journal of Clinical Investigation, 117 (3):636-647. Available Online [Details]
Roosterman, D., Kreuzer, O.J., Brune, N., Cottrell, G.S., Bunnett, N.W., Meyerhof, W., Steinhoff, M. (2007) 'Agonist-induced endocytosis of rat somatostatin receptor 1'. Endocrinology, 148 (3):1050-1058. Available Online [Details]
Busso, N., Frasnelli, M., Feifel, R., Cenni, B., Steinhoff, M., Hamilton, J., So, A. (2007) 'Evaluation of protease-activated receptor 2 in murine models of arthritis'. Arthritis and Rheumatism, 56 (1):101-107. Available Online [Details]
Asfaha, S., Cenac, N., Houle, S., Altier, C., Papez, M.D., Nguyen, C., Steinhoff, M., Chapman, K., Zamponi, G.W., Vergnolle, N. (2007) 'Protease-activated receptor-4: A novel mechanism of inflammatory pain modulation'. British Journal of Pharmacology, 150 (2):176-185. Available Online [Details]
Padilla, B.E., Cottrell, G.S., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M., Bunnett, N.W. (2007) 'Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and β-arrestins'. Journal of Cell Biology, 179 (5):981-997. Available Online [Details]
Shpacovitch, V., Feld, M., Bunnett, N.W., Steinhoff, M. (2007) 'Protease-activated receptors: novel PARtners in innate immunity'. Trends in Immunology, 28 (12):535-544. Available Online [Details]
Sachse, F., Von Eiff, C., Becker, K., Steinhoff, M., Rudack, C. (2007) 'Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-α responses in primary human nasal epithelial cells'. International Archives of Allergy and Immunology, 145 (1):24-32. Available Online [Details]
Pivarcsi, A., Müller, A., Hippe, A., Rieker, J., Van Lierop, A., Steinhoff, M., Seeliger, S., Kubitza, R., Pippirs, U., Meller, S., Gerber, P.A., Liersch, R., Buenemann, E., Sonkoly, E., Wiesner, U., Hoffmann, T.K., Schneider, L., Piekorz, R., Enderlein, E., Reifenberger, J., Rohr, U.-P., Haas, R., Boukamp, P., Haase, I., Nürnberg, B., Ruzicka, T., Zlotnik, A., Homey, B. (2007) 'Tumor immune escape by the loss of homeostatic chemokine expression'. Proceedings of the National Academy of Sciences of the United States of America, 104 (48):19055-19060. Available Online [Details]
Shpacovitch, V.M., Seeliger, S., Huber-lang, M., Balkow, S., Feld, M., Hollenberg, M.D., Sarma, V.J., Ward, P.A., Strey, A., Gerke, V., Sommerhoff, C.P., Vergnolle, N., Steinhoff, M. (2007) 'Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils'. Experimental Dermatology, 16 (10):799-806. Available Online [Details]
Cevikbas, F., Steinhoff, A., Homey, B., Steinhoff, M. (2007) 'Neuroimmune interactions in allergic skin diseases'. Current Opinion in Allergy and Clinical Immunology, 7 (5):365-373. Available Online [Details]
Rattenholl, A., Seeliger, S., Buddenkotte, J., Schön, M., Schön, M.P., Ständer, S., Vergnolle, N., Steinhoff, M. (2007) 'Proteinase-activated receptor-2 (PAR2): A tumor suppressor in skin carcinogenesis'. Journal of Investigative Dermatology, 127 (9):2245-2252. Available Online [Details]
Goerge, T., Kleinerüschkamp, F., Barg, A., Schnaeker, E.-M., Huck, V., Schneider, M.F., Steinhoff, M., Schneider, S.W. (2007) 'Microfluidic reveals generation of platelet-strings on tumor-activated endothelium'. Thrombosis and Haemostasis, 98 (2):283-286. Available Online [Details]
Roosterman, D., Cottrell, G.S., Padilla, B.E., Muller, L., Eckman, C.B., Bunnett, N.W., Steinhoff, M. (2007) 'Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling'. Proceedings of the National Academy of Sciences of the United States of America, 104 (28):11838-11843. Available Online [Details]
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., Sharkey, K. A., Ferraz, J. G., Shaffer, E., Vergnolle, N. (2007) 'Role for protease activity in visceral pain in irritable bowel syndrome'. J Clin Invest, 117 (3):636-47. Available Online [Details]
Kindt, F., Wiegand, S., Loser, C., Nilles, M., Niemeier, V., Hsu, S. Y., Steinhoff, M., Kummer, W., Gieler, U., Haberberger, R. V. (2007) 'Intermedin: a skin peptide that is downregulated in atopic dermatitis'. J Invest Dermatol, 127 (3):605-13. Available Online [Details]
Lan Ma, H., Metze, D., Luger, T. A., Steinhoff, M. (2007) 'Successful treatment of generalized eruptive histiocytoma with PUVA'. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 5 (2):131-4. Available Online [Details]
Pivarcsi, A., Muller, A., Hippe, A., Rieker, J., van Lierop, A., Steinhoff, M., Seeliger, S., Kubitza, R., Pippirs, U., Meller, S., Gerber, P. A., Liersch, R., Buenemann, E., Sonkoly, E., Wiesner, U., Hoffmann, T. K., Schneider, L., Piekorz, R., Enderlein, E., Reifenberger, J., Rohr, U. P., Haas, R., Boukamp, P., Haase, I., Nurnberg, B., Ruzicka, T., Zlotnik, A., Homey, B. (2007) 'Tumor immune escape by the loss of homeostatic chemokine expression'. Proc Natl Acad Sci U S A, 104 (48):19055-60. Available Online [Details]
Rudack, C., Steinhoff, M., Mooren, F., Buddenkotte, J., Becker, K., von Eiff, C., Sachse, F. (2007) 'PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium'. Clin Exp Allergy, 37 (7):1009-22. Available Online [Details]
Shpacovitch, V. M., Seeliger, S., Huber-Lang, M., Balkow, S., Feld, M., Hollenberg, M. D., Sarma, V. J., Ward, P. A., Strey, A., Gerke, V., Sommerhoff, C. P., Vergnolle, N., Steinhoff, M. (2007) 'Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils'. Exp Dermatol, 16 (10):799-806. Available Online [Details]
Stander, S., Stander, H., Seeliger, S., Luger, T. A., Steinhoff, M. (2007) 'Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin'. The British journal of dermatology, 156 (5):1020-6. Available Online [Details]
Rudack, C., Steinhoff, M., Mooren, F., Buddenkotte, J., Becker, K., Von Eiff, C., Sachse, F. (2007) 'PAR-2 activation regulates IL-8 and GRO-α synthesis by NF-κB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium'. Clinical and Experimental Allergy, 37 (7):1009-1022. Available Online [Details]
Shpacovitch, V., Feld, M., Hollenberg, M.D., Luger, T.A., Steinhoff, M. (2008) 'Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity'. Journal of Leukocyte Biology, 83 (6):1309-1322. Available Online [Details]
Roosterman, D., Kempkes, C., Cottrell, G.S., Padilla, B.E., Bunnett, N.W., Turck, C.W., Steinhoff, M. (2008) 'Endothelin-converting enzyme-1 degrades internalized somatostatin-14'. Endocrinology, 149 (5):2200-2207. Available Online [Details]
Elias, P.M., Steinhoff, M. (2008) 'Outside-to-inside (and now back to outside) pathogenic mechanisms in atopic dermatitis'. Journal of Investigative Dermatology, 128 (5):1067-1070. Available Online [Details]
Stefansson, K., Brattsand, M., Roosterman, D., Kempkes, C., Bocheva, G., Steinhoff, M., Egelrud, T. (2008) 'Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases'. Journal of Investigative Dermatology, 128 (1):18-25. Available Online [Details]
Ehrchen, J., Sunderkötter, C., Luger, T., Steinhoff, M. (2008) 'Calcineurin inhibitors for the treatment of atopic dermatitis'. Expert Opinion on Pharmacotherapy, 9 (17):3009-3023. Available Online [Details]
Feld, M., Shpacovitch, V.M., Ehrhardt, C., Kerkhoff, C., Hollenberg, M.D., Vergnolle, N., Ludwig, S., Steinhoff, M. (2008) 'Agonists of proteinase-activated receptor-2 enhance IFN-γ-inducible effects on human monocytes: Role in influenza A infection'. Journal of Immunology, 180 (10):6903-6910. Available Online [Details]
Roosterman, D., Brune, N.E.I., Kreuzer, O.J., Feld, M., Pauser, S., Zarse, K., Steinhoff, M., Meyerhof, W. (2008) 'Intracellular degradation of somatostatin-14 following somatostatin- receptor 3-mediated endocytosis in rat insulinoma cells'. FEBS Journal, 275 (19):4728-4739. Available Online [Details]
Roosterman, D., Brune, N. E., Kreuzer, O. J., Feld, M., Pauser, S., Zarse, K., Steinhoff, M., Meyerhof, W. (2008) 'Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells'. Febs J, 275 (19):4728-39. Available Online [Details]
Sachse, F., von Eiff, C., Becker, K., Steinhoff, M., Rudack, C. (2008) 'Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells'. Int Arch Allergy Immunol, 145 (1):24-32. Available Online [Details]
Rattenholl, A., Steinhoff, M. (2008) 'Proteinase-activated receptor-2 in the skin: Receptor expression, activation and function during health and disease'. Drug News and Perspectives, 21 (7):369-381. Available Online [Details]
Bocheva, G., Rattenholl, A., Kempkes, C., Goerge, T., Lin, C.-Y., D'Andrea, M.R., Ständer, S., Steinhoff, M. (2009) 'Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer'. Journal of Investigative Dermatology, 129 (7):1816-1823. Available Online [Details]
Steinhoff, M., Bíró, T. (2009) 'A TR(I)P to pruritus research: Role of TRPV3 in inflammation and itch'. Journal of Investigative Dermatology, 129 (3):531-535. Available Online [Details]
Auge, C., Balz-Hara, D., Steinhoff, M., Vergnolle, N., Cenac, N. (2009) 'Protease-activated receptor-4 (PAR 4): a role as inhibitor of visceral pain and hypersensitivity'. Neurogastroenterol Motil, 21 (11). Available Online [Details]
Cottrell, G. S., Padilla, B. E., Amadesi, S., Poole, D. P., Murphy, J. E., Hardt, M., Roosterman, D., Steinhoff, M., Bunnett, N. W. (2009) 'Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling'. J Biol Chem, 284 (33):22411-25. Available Online [Details]
Martin, L., Augé, C., Boué, J., Buresi, M.C., Chapman, K., Asfaha, S., Andrade-Gordon, P., Steinhoff, M., Cenac, N., Dietrich, G., Vergnolle, N. (2009) 'Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways'. Pain, 146 (1-2):121-129. Available Online [Details]
Hyun, E., Andrade-Gordon, P., Steinhoff, M., Beck, P.L., Vergnolle, N. (2010) 'Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis'. Inflammation Research, 59 (9):699-709. Available Online [Details]
Goerge, T., Weishaupt, C., Metze, D., Nowak-Göttl, U., Sunderkötter, C., Steinhoff, M., Schneider, S.W. (2010) 'Livedoid vasculopathy in a pediatric patient with elevated lipoprotein(a) levels: Prompt response to continuous low-molecular-weight heparin'. Archives of Dermatology, 146 (8):927-928. Available Online [Details]
Feramisco, J.D., Berger, T.G., Steinhoff, M. (2010) 'Innovative management of pruritus'. Dermatologic Clinics, 28 (3):467-478. Available Online [Details]
Gerber, P.A., Buhren, B.A., Cevikbas, F., Bölke, E., Steinhoff, M., Homey, B. (2010) 'Preliminary evidence for a role of mast cells in epidermal growth factor receptor inhibitor-induced pruritus'. Journal of the American Academy of Dermatology, 63 (1):163-165. Available Online [Details]
Buddenkotte, J., Steinhoff, M. (2010) 'Pathophysiology and therapy of pruritus in allergic and atopic diseases'. Allergy: European Journal of Allergy and Clinical Immunology, 65 (7):805-821. Available Online [Details]
Briot, A., Lacroix, M., Robin, A., Steinhoff, M., Deraison, C., Hovnanian, A. (2010) 'Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in netherton syndrome adult mouse model'. Journal of Investigative Dermatology, 130 (12):2736-2742. Available Online [Details]
Buddenkotte, J., Maurer, M., Steinhoff, M. (2010) 'Histamine and antihistamines in atopic dermatitis'. Advances in Experimental Medicine and Biology, 709 :73-80. Available Online [Details]
Eickelmann, M., Steinhoff, M., Metze, D., Tomimori-Yamashita, J., Sunderkotter, C. (2010) 'Erythema leprosum--after treatment of Lepromatous Leprosy'. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 8 (6):450-3. Available Online [Details]
Feld, M., Shpacovitch, V. M., Fastrich, M., Cevikbas, F., Steinhoff, M. (2010) 'Interferon-gamma induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells'. Exp Dermatol, 19 (10):921-3. Available Online [Details]
Pauser, S., Goerge, T., Gaubitz, P., Metze, D., Luger, T., Steinhoff, M. (2010) 'Pyoderma gangraenosum in a patient after sectio caesarea'. Clinical Medicine: Dermatology, . [Details]
Seeliger, S., Buddenkotte, J., Schmidt-Choudhury, A., Rosignoli, C., Shpacovitch, V., Von Arnim, U., Metze, D., Rukwied, R., Schmelz, M., Paus, R., Voegel, J.J., Schmidt, W.E., Steinhoff, M. (2010) 'Pituitary adenylate cyclase activating polypeptide: An important vascular regulator in human skin in vivo'. American Journal of Pathology, 177 (5):2563-2575. Available Online [Details]
Pelayo, J.-C., Poole, D.P., Steinhoff, M., Cottrell, G.S., Bunnett, N.W. (2011) 'Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones'. Journal of Physiology, 589 (21):5213-5230. Available Online [Details]
Liu, Q., Weng, H.-J., Patel, K.N., Tang, Z., Bai, H., Steinhoff, M., Dong, X. (2011) 'The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia'. Science Signaling, 4 (181). Available Online [Details]
Hong, J., Buddenkotte, J., Berger, T.G., Steinhoff, M. (2011) 'Management of itch in atopic dermatitis'. Seminars in Cutaneous Medicine and Surgery, 30 (2):71-86. Available Online [Details]
Berger, T.G., Steinhoff, M. (2011) 'Pruritus and renal failure'. Seminars in Cutaneous Medicine and Surgery, 30 (2):99-100. Available Online [Details]
Berger, T.G., Steinhoff, M. (2011) 'Pruritus/itch: the science and treatment. Introduction'. Seminars in cutaneous medicine and surgery, 30 (2). Available Online [Details]
Ikoma, A., Cevikbas, F., Kempkes, C., Steinhoff, M. (2011) 'Anatomy and neurophysiology of pruritus'. Seminars in Cutaneous Medicine and Surgery, 30 (2):64-70. Available Online [Details]
Berger, T.G., Steinhoff, M. (2011) 'Pruritus in elderly patients-eruptions of senescence'. Seminars in Cutaneous Medicine and Surgery, 30 (2):113-117. Available Online [Details]
Steinhoff, M., Cevikbas, F., Ikoma, A., Berger, T.G. (2011) 'Pruritus: Management algorithms and experimental therapies'. Seminars in Cutaneous Medicine and Surgery, 30 (2):127-137. Available Online [Details]
Frateschi, S., Camerer, E., Crisante, G., Rieser, S., Membrez, M., Charles, R.-P., Beermann, F., Stehle, J.-C., Breiden, B., Sandhoff, K., Rotman, S., Haftek, M., Wilson, A., Ryser, S., Steinhoff, M., Coughlin, S.R., Hummler, E. (2011) 'PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin'. Nature Communications, 2 (1). Available Online [Details]
Cevikbas, F., Seeliger, S., Fastrich, M., Hinte, H., Metze, D., Kempkes, C., Homey, B., Steinhoff, M. (2011) 'Role of protease-activated receptors in human skin fibrosis and scleroderma'. Experimental Dermatology, 20 (1):69-71. Available Online [Details]
Scharschmidt, T.C., Yost, J.M., Truong, S.V., Steinhoff, M., Wang, K.C., Berger, T.G. (2011) 'Neurogenic rosacea: A distinct clinical subtype requiring a modified approach to treatment'. Archives of Dermatology, 147 (1):123-126. Available Online [Details]
Schwab, V.D., Sulk, M., Seeliger, S., Nowak, P., Aubert, J., Mess, C., Rivier, M., Carlavan, I., Rossio, P., Metze, D., Buddenkotte, J., Cevikbas, F., Voegel, J.J., Steinhoff, M. (2011) 'Neurovascular and neuroimmune aspects in the pathophysiology of rosacea'. Journal of Investigative Dermatology Symposium Proceedings, 15 (1):53-62. Available Online [Details]
Cevikbas, F., Steinhoff, M., Ikoma, A. (2011) 'Role of spinal neurotransmitter receptors in itch: New insights into therapies and drug development'. CNS Neuroscience and Therapeutics, 17 (6):742-749. Available Online [Details]
Steinhoff, M., Ikoma, A. (2011) 'Dissecting itch and pain sensations in human skin'. Pain, 152 (11):2453-2454. Available Online [Details]
Steinhoff, M., Buddenkotte, J., Aubert, J., Sulk, M., Novak, P., Schwab, V.D., Mess, C., Cevikbas, F., Rivier, M., Carlavan, I., Déret, S., Rosignoli, C., Metze, D., Luger, T.A., Voegel, J.J. (2011) 'Clinical, cellular, and molecular aspects in the pathophysiology of rosacea'. Journal of Investigative Dermatology Symposium Proceedings, 15 (1):2-11. Available Online [Details]
Gerber, P.A., Buhren, B.A., Steinhoff, M., Homey, B. (2011) 'Rosacea: The cytokine and chemokine network'. Journal of Investigative Dermatology Symposium Proceedings, 15 (1):40-47. Available Online [Details]
Frateschi, S., Camerer, E., Crisante, G., Rieser, S., Membrez, M., Charles, R. P., Beermann, F., Stehle, J. C., Breiden, B., Sandhoff, K., Rotman, S., Haftek, M., Wilson, A., Ryser, S., Steinhoff, M., Coughlin, S. R., Hummler, E. (2011) 'PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin'. Nat Commun, 2 . Available Online [Details]
Liu, Q., Weng, H. J., Patel, K. N., Tang, Z., Bai, H., Steinhoff, M., Dong, X. (2011) 'The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia'. Science signaling, 4 (181). Available Online [Details]
Murphy, J. E., Roosterman, D., Cottrell, G. S., Padilla, B. E., Feld, M., Brand, E., Cedron, W. J., Bunnett, N. W., Steinhoff, M. (2011) 'Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor'. Am J Physiol Cell Physiol, 301 (4). Available Online [Details]
Scharschmidt, T. C., Yost, J. M., Truong, S. V., Steinhoff, M., Wang, K. C., Berger, T. G. (2011) 'Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment'. Archives of dermatology, 147 (1):123-6. Available Online [Details]
Shpacovitch, V. M., Feld, M., Holzinger, D., Kido, M., Hollenberg, M. D., Levi-Schaffer, F., Vergnolle, N., Ludwig, S., Roth, J., Luger, T., Steinhoff, M. (2011) 'Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes'. Immunology, 133 (3):329-39. Available Online [Details]
Steinhoff, M., Bergstresser, P. R. (2011) 'Pathophysiology of rosacea: introduction'. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 15 (1). Available Online [Details]
Steinhoff, M., Buddenkotte, J., Aubert, J., Sulk, M., Novak, P., Schwab, V. D., Mess, C., Cevikbas, F., Rivier, M., Carlavan, I., Deret, S., Rosignoli, C., Metze, D., Luger, T. A., Voegel, J. J. (2011) 'Clinical, cellular, and molecular aspects in the pathophysiology of rosacea'. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 15 (1):2-11. Available Online [Details]
Steinhoff, M., Bergstresser, P.R. (2011) 'Pathophysiology of rosacea: Introduction'. Journal of Investigative Dermatology Symposium Proceedings, 15 (1). Available Online [Details]
Suárez, A.L., Feramisco, J.D., Koo, J., Steinhoff, M. (2012) 'Psychoneuroimmunology of psychological stress and atopic dermatitis: Pathophysiologic and therapeutic updates'. Acta Dermato-Venereologica, 92 (1):7-15. Available Online [Details]
Steinhoff, M., Cevikbas, F., Yeh, I., Chong, K., Buddenkotte, J., Ikoma, A. (2012) 'Evaluation and management of a patient with chronic pruritus'. Journal of Allergy and Clinical Immunology, 130 (4):1015-1016. Available Online [Details]
Feld, M., Goerge, T., Hillgruber, C., Steingräber, A.K., Fastrich, M., Shpacovitch, V., Steinhoff, M. (2012) 'α-1-antitrypsin and IFN-γ reduce the severity of IC-mediated vasculitis by regulation of leukocyte recruitment in vivo'. Journal of Investigative Dermatology, 132 (9):2286-2295. Available Online [Details]
Akiyama, T., Carstens, M.I., Ikoma, A., Cevikbas, F., Steinhoff, M., Carstens, E. (2012) 'Mouse model of touch-evoked itch (alloknesis)'. Journal of Investigative Dermatology, 132 (7):1886-1891. Available Online [Details]
Cevikbas, F., Steinhoff, M. (2012) 'IL-33: A novel danger signal system in atopic dermatitis'. Journal of Investigative Dermatology, 132 (5):1326-1329. Available Online [Details]
Kwapiszewska, G., Markart, P., Dahal, B.K., Kojonazarov, B., Marsh, L.M., Schermuly, R.T., Taube, C., Meinhardt, A., Ghofrani, H.A., Steinhoff, M., Seeger, W., Preissner, K.T., Olschewski, A., Weissmann, N., Wygrecka, M. (2012) 'PAR-2 inhibition reverses experimental pulmonary hypertension'. Circulation Research, 110 (9):1179-1191. Available Online [Details]
Sulk, M., Seeliger, S., Aubert, J., Schwab, V.D., Cevikbas, F., Rivier, M., Nowak, P., Voegel, J.J., Buddenkotte, J., Steinhoff, M. (2012) 'Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea'. Journal of Investigative Dermatology, 132 (4):1253-1262. Available Online [Details]
Kempkes, C., Rattenholl, A., Buddenkotte, J., Strozyk, E., Eberle, J., Hausser, A., Cevikbas, F., Schneider, S.W., Steinhoff, M. (2012) 'Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1'. Journal of Investigative Dermatology, 132 (2):375-384. Available Online [Details]
Gobbetti, T., Cenac, N., Motta, J.-P., Rolland, C., Martin, L., Andrade-Gordon, P., Steinhoff, M., Barocelli, E., Vergnolle, N. (2012) 'Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine'. American Journal of Pathology, 180 (1):141-152. Available Online [Details]
Feld, M., Goerge, T., Hillgruber, C., Steingraber, A. K., Fastrich, M., Shpacovitch, V., Steinhoff, M. (2012) 'alpha-1-Antitrypsin and IFN-gamma reduce the severity of IC-mediated vasculitis by regulation of leukocyte recruitment in vivo'. J Invest Dermatol, 132 (9):2286-95. Available Online [Details]
Feramisco, J. D., George, T., Schulz, S. E., Ma, H. L., Metze, D., Steinhoff, M. (2012) 'Disseminated erosive pustular dermatosis also involving the mucosa: successful treatment with oral dapsone'. Acta dermato-venereologica, 92 (1):91-2. Available Online [Details]
Fowler, J., Jarratt, M., Moore, A., Meadows, K., Pollack, A., Steinhoff, M., Liu, Y., Leoni, M. (2012) 'Once-daily topical brimonidine tartrate gel 0.5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies'. The British journal of dermatology, 166 (3):633-41. Available Online [Details]
Gobbetti, T., Cenac, N., Motta, J. P., Rolland, C., Martin, L., Andrade-Gordon, P., Steinhoff, M., Barocelli, E., Vergnolle, N. (2012) 'Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine'. Am J Pathol, 180 (1):141-52. Available Online [Details]
Feramisco, J.D., Goerge, T., Schulz, S.E., Ma, H.L., Metze, D., Steinhoff, M. (2012) 'Disseminated erosive pustular dermatosis also involving the mucosa: Successful treatment with oral dapsone'. Acta Dermato-Venereologica, 92 (1):91-92. Available Online [Details]
Feld, M., Shpacovitch, V., Ehrhardt, C., Fastrich, M., Goerge, T., Ludwig, S., Steinhoff, M. (2013) 'Proteinase-activated receptor-2 agonist activates anti-influenza mechanisms and modulates IFN γ -induced antiviral pathways in human neutrophils'. BioMed Research International, 2013 . Available Online [Details]
Schauber, J., Homey, B., Steinhoff, M. (2013) 'Current insights into the pathophysiology of rosacea [Aktuelles Verständnis der Pathophysiologie der Rosazea]'. Hautarzt, 64 (7):481-488. Available Online [Details]
Pincelli, C., Steinhoff, M. (2013) 'Recapitulating atopic dermatitis in three dimensions: Cross talk between keratinocytes and nerve fibers'. Journal of Investigative Dermatology, 133 (6):1465-1467. Available Online [Details]
Weinstock, L.B., Steinhoff, M. (2013) 'Rosacea and small intestinal bacterial overgrowth: Prevalence and response to rifaximin'. Journal of the American Academy of Dermatology, 68 (5):875-876. Available Online [Details]
Alemi, F., Kwon, E., Poole, D. P., Lieu, T., Lyo, V., Cattaruzza, F., Cevikbas, F., Steinhoff, M., Nassini, R., Materazzi, S., Guerrero-Alba, R., Valdez-Morales, E., Cottrell, G. S., Schoonjans, K., Geppetti, P., Vanner, S. J., Bunnett, N. W., Corvera, C. U. (2013) 'The TGR5 receptor mediates bile acid-induced itch and analgesia'. J Clin Invest, 123 (4):1513-30. Available Online [Details]
Cattaruzza, F., Johnson, C., Leggit, A., Grady, E., Schenk, A. K., Cevikbas, F., Cedron, W., Bondada, S., Kirkwood, R., Malone, B., Steinhoff, M., Bunnett, N., Kirkwood, K. S. (2013) 'Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice'. Am J Physiol Gastrointest Liver Physiol, 304 (11). Available Online [Details]
Eissa, A., Cretu, D., Soosaipillai, A., Thavaneswaran, A., Pellett, F., Diamandis, A., Cevikbas, F., Steinhoff, M., Diamandis, E. P., Gladman, D., Chandran, V. (2013) 'Serum kallikrein-8 correlates with skin activity, but not psoriatic arthritis, in patients with psoriatic disease'. Clin Chem Lab Med, 51 (2):317-25. Available Online [Details]
Fowler Jr, Joseph, Jackson, M., Moore, Angela, Jarratt, Michael, Jones, Terry, Meadows, Kappa, Steinhoff, Martin, Rudisill, Diane, Leoni, Matthew (2013) 'Efficacy and Safety of Once-Daily Topical Brimonidine Tartrate Gel 0.5% for the Treatment of Moderate to Severe Facial Erythema of Rosacea: Results of Two Randomized, Double-blind, and Vehicle-Controlled Pivotal Studies'. Journal of drugs in dermatology: JDD, 12 (6):650-656. [Details]
Herrmann, E., Weishaupt, C., Poppelmann, B., Hillgruber, C., Puhse, G., Krabbe, L. M., Feld, M., Steinhoff, M., Goerge, T. (2013) 'New tools for assessing the individual risk of metastasis in renal cell carcinoma'. Clin Exp Metastasis, 30 (2):215-24. Available Online [Details]
Affara, N. I., Ruffell, B., Medler, T. R., Gunderson, A. J., Johansson, M., Bornstein, S., Bergsland, E., Steinhoff, M., Li, Y., Gong, Q., Ma, Y., Wiesen, J. F., Wong, M. H., Kulesz-Martin, M., Irving, B., Coussens, L. M. (2014) 'B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas'. Cancer Cell, . Available Online [Details]
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., Soumelis, V., Feld, M., Alenius, H., Dillon, S. R., Carstens, E., Homey, B., Basbaum, A., Steinhoff, M. (2014) 'A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1'. J Allergy Clin Immunol, 133 (2):448-60. Available Online [Details]
Jackson, J. Mark, Fowler, Joseph, Moore, Angela, Jarratt, Michael, Jones, Terry, Meadows, Kappa, Steinhoff, Martin, Rudisill, Diane, Leoni, Matthew (2014) 'Improvement in facial erythema within 30 minutes of initial application of brimonidine tartrate in patients with rosacea'. Journal of drugs in dermatology: JDD, 13 (6):699-704. [Details]
Kido-Nakahara, M., Buddenkotte, J., Kempkes, C., Ikoma, A., Cevikbas, F., Akiyama, T., Nunes, F., Seeliger, S., Hasdemir, B., Mess, C., Buhl, T., Sulk, M., Muller, F. U., Metze, D., Bunnett, N. W., Bhargava, A., Carstens, E., Furue, M., Steinhoff, M. (2014) 'Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus'. J Clin Invest, . Available Online [Details]
Steinhoff, M.S., von Mentzer, B., Geppetti, P., Pothoulakis, C., Bunnett, N.W. (2014) 'Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease'. Physiological Reviews, 94 (1):265-301. Available Online [Details]
                                                                                             

Research

Research Interests

Research Projects

Sponsor : The City of Dublin Skin and Cancer Hospital Charity
Title : Charles Institute Research Award
Start Date / End Date : 01-AUG-12 / 31-DEC-17
Sponsor : University College Dublin (UCD)
Title : Charles Institute Research Award
Start Date / End Date : 01-AUG-12 / 31-DEC-17
 

Current Postgraduate Students

Hassanin Jalil Al-Aasam, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Collaborators

Internal Collaborators

Prof B. Kholodenko, Deputy Director, Systems Biology Ireland , UCD, Dublin, Ireland.
 
Prof. Dr. W. Kolch, Director, Conway Institute and Systems Biology Ireland , UCD, Dublin, Ireland.

External Collaborators

SCIENTIFIC COLLABORATIONS
 
Prof. Dr. S. Brain, Dept. of Pharmacology, King's College, London, UK, Neuropeptide receptors in  skin inflammation.
 
Prof. Dr. Nigel W. Bunnett, Dept. of Pharmacology, Monash University, Melbourne, Australia
 
Prof. Dr. Z.F. Chen, Dept. of Anesthesiology, Washington University, St. Louis, MO, USA: GRP, cytokines and pruritus
 
Prof. Dr. S. Coughlin, Director, Cardiovascular Research Center, University of California San Francisco, UCSF, San Francisco: protease-activated receptors
 
Dr. S. Dillon. BMS/ZymoGenetics. Seattle, USA
 
Prof. Dr. M. D. Hollenberg, Chair, Dept. of Pharmacology, Calgary, Canada: protease-activated receptors
 
Prof. Dr. B. Homey, Chair, Dept. of Dermatology, University of Dusseldorf, Germany.  Cytokine and chemokine receptors, Itch; atopic dermatitis
 
Prof. Dr. A. Hovnanian, INSERM. Dept. of Genetics, Paris, France: proteases in atopic dermatitis.
 
Prof. Dr. R. Locksley, Dept. of Immunology, University of California San Francisco, UCSF, San Francisco. Interleukin-33 and ST2 in skin diseases.
 
Prof. Dr. S. McMahoon, Chair, Professor of Physiology, King¿s Collge London, UK.
Molecular Mechanisms of Itch and Pain
 
Prof. Dr. LJ Ptacek and Prof. Dr. YH Fu, Dept. of Neurology, University of California San Francisco, UCSF, San Francisco. Genetics of rosacea.
 
Prof. Dr. C. Turck, Max-Planck Institut für Psychatrie, München: Proteomics in skin diseases and neurogenic inflammation.