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Researchers at UCD

Michael Keane

Professor of Medicine and Therapeutics

School Of Medicine & Medical Science
St Vincent's Hospital
Elm Park
Dublin 4

Tel: +353 1 716
Email: michael.p.keane@ucd.ie

Professional

Honours and Awards

Year: 0.
Title: Kirwan Medal and Prize in Ophthalmology
Year: 0.
Title: Catholic University Scholarship
Year: 1987.
Title: AFMR, Midwest Trainee Investigator Award

Associations

Association: American Journal of Respiratory and Critical Care Medicine, Function/Role: Editorial Board
Association: Journal of Immunology, Function/Role: Associate Editor
Association: American Journal of Physiology, Lung Cellular and Molecular Physiology, Function/Role: Editorial Board
Association: American Thoracic Society, Function/Role:
Association: American College of Chest Physicians, Function/Role:
Association: American Association of Immunology, Function/Role:
Association: Fellow American College of Chest Physicians, Function/Role:
Association: Society of Critical Care Medicine, Function/Role:
     

Conference Contributions

Belperio JA, Nakumura H, Xu YY, Pan J, Burdick MD, Strieter RM, Grusby M, Keane MP. ; (2006) The IL-13R2 receptor attenuates FITC induced pulmonary fibrosis. [Refereed Abstracts], American Thoracic Society Meeting, San Diego, CA , 01-MAY-06.
Keane MP, Chung J, Liu W, Elashoff R, Belperio JA, Roth MD, Silver RM, Strange C, Sterz M, Clements PJ, Furst DE, Zisman DA, Goldin J, Burdick MD, Strieter RM, Tashkin DP for the Scleroderma Lung Study Group. ; (2006) Correlation of BAL chemokines with clinical parameters in scleroderma lung disease. [Refereed Abstracts], American Thoracic Society Meeting, San Diego, CA , 01-MAY-06.
Keane MP, Chung J, Liu W, Elashoff R, Belperio JA, Roth MD, Silver RM, Strange C, Sterz M, Clements PJ, Furst DE, Zisman DA, Goldin J, Burdick MD, Strieter RM, Tashkin DP for the Scleroderma Lung Study Group. ; (2006) Correlation of BAL chemokines with clinical parameters in scleroderma lung disease. [Refereed Abstracts], Aspen Lung Conference, Immunological Lung Disease, * , 07-JUN-06 - 10-JUN-06.
Belperio JA, Nakumura H, Xu YY, Pan J, Burdick MD, Strieter RM, Grusby M, Keane MP. ; (2006) The IL-13R2 receptor attenuates lung injury and remodeling. [Refereed Abstracts], Aspen Lung Conference, Immunological Lung Disease, * , 07-JUN-06 - 10-JUN-06.
Keane, M.; (2005) Facilitator, A-58 Mechanisms of Pulmonary Fibrosis. [Other], American Thoracic Society International Scientific Meeting, San Diego, CA , 22-MAY-05.
Keane, M.; (2005) Poster Discussion Session, A-28 Mechanisms of fibroblast survival and proliferation. [Chaired Session], American Thoracic Society International Scientific Meeting, San Diego, CA , 22-MAY-05.
Keane, M.; (2003) 'Sepsis Syndrome'. [Invited Lecture], *, Henry Mayo Newhall Hospital, Santa Clarita, CA , 13-FEB-03.
Keane, M.; (2003) 'Crosstalk Between the Innate and Adaptive Immune Systems'. [Invited Lecture], Symposium on Innate Immunity: Structure and Function, American Academy of Allergy Asthma and Immunology 60th Anniversary Meeting, Denver CO , 10-MAR-03.
Keane, M.; (2003) 'COPD'. [Invited Lecture], Kaiser Permanante Acute Care Symposium, Lakewood CA , 27-MAR-03.
Keane, M.; (2003) 'COPD'. [Invited Lecture], UCLA Primary Care Update, Las Vegas, NV , 11-APR-03.
Keane, M.; (2003) 'Thromboembolic Disease'. [Invited Lecture], *, Garfield Medical Center, Monterey Park, CA , 24-APR-03.
Keane, M.; (2003) 'Idiopathic Pulmonary Fibrosis'. [Invited Lecture], Pulmonary Grand Rounds, Cedars Sinai Medical Center, Los Angeles, CA , 23-APR-03.
Keane, M.; (2003) AFMR Western Regional Meeting, Pulmonary and Critical Care II. [Chaired Session], AFMR Western Regional Meeting, Pulmonary and Critical Care II, * , 01-FEB-03.
Keane, M.; (2003) Chairperson, IPF: Biological Mechanisms of Disease. [Chaired Session], American Thoracic Society International Scientific Meeting, Seattle, WA , 21-MAY-03.
Keane, M.; (2002) 'Idiopathic Pulmonary Fibrosis',. [Invited Lecture], Board Review, West Los Angeles VA , 29-AUG-02.
Keane, M.; (2002) 'Thromboembolic Disease',. [Invited Lecture], *, Irvine Regional Medical Center, Irvine, CA , 24-OCT-02.
Kerane, M.; (2002) Chairperson, IPF pathogenesis. [Conference Organising Committee Chairperson], American Thoracic Society International Scientific Meeting, Atlanta, GA , 19-MAY-02.
Keane, M.; (2002) 'Pulmonary Embolism'. [Invited Lecture], *, Pacifica Hospital, Los Angeles , 01-MAR-02.
Keane, M.; (2002) IPF: everything you ever wanted to know. [Conference Organising Committee Chairperson], American Thoracic Society International Scientific Meeting, Atlanta, GA , 19-MAY-02.
Keane, M.; (2002) 'Update on Cystic Fibrosis'. [Invited Lecture], UCLA Pulmonary and Critical Care Update, Marina Del Rey, CA , 19-JUL-02.
Keane, M.; (2002) 'Idiopathic Pulmonary Fibrosis'. [Invited Lecture], Pulmonary Grand Rounds, Cedars Sinai Medical Center, Los Angeles, CA , 15-MAY-02.
Keane, M.; (2002) UCLA Pulmonary and Critical Care Update. [Conference Organising Committee Chairperson], UCLA Pulmonary and Critical Care Update, Marina Del Rey, CA , 20-JUL-02.
Keane, M.; (2007) Poster Discussion Session, Interstitial Lung Disease Biology. [Chaired Session], American Thoracic Society International Scientific Meeting, San Francisco, CA , 23-MAY-07.
Keane, M.; (2007) Animal Models of Fibrosis. [Chaired Session], Keystone symposium on Mechanisms of Fibrosis, Lake Tahoe, CA , 12-MAR-07.
Keane, M.; (2006) Mini-symposium, Novel molecular mechanisms in pulmonary fibrosis. [Chaired Session], American Thoracic Society International Scientific Meeting, San Diego, CA , 24-MAY-06.
Keane, M.; (2005) Angiogenesis in pulmonary fibrosis. [Invited Lecture], European Respiratory Society, Copenhagen, Denmark , 18-SEP-05.
Keane, M.; (2003) Endothelin and angiogenesis. [Invited Lecture], The endothelin system in cardiopulmonary diseases, Rome, Italy , 29-JUN-03.
Keane, M.; (2002) Idiopathic Pulmonary Fibrosis, Current controversies in diagnosis and treatment. [Invited Lecture], St Vincent's Hospital, University College Dublin, Dublin , 15-MAR-02.
Keane, M.; (2007) Chemokines and their receptors: What role in fibrogenesis. [Invited Lecture], ATS International Conference, San Francisco, USA , 23-MAY-07.
Keane, M.; (2007) Treating Scleroderma ILD: Lessons from the Scleroderma Lung Study. [Invited Lecture], ATS International Conference, San Francisco , 22-MAY-07.
Keane, M.; (2007) 'ICU of the future'. [Invited Lecture], UCLA department of Neurosurgery symposium, * , 26-JAN-07.
Keane, M.; (2006) 'Idiopathic Pulmonary Fibrosis'. [Invited Lecture], Harbor UCLA Medical Center, CA, Harbor UCLA Medical Center, CA , 18-OCT-06.
Keane, M.; (2006) 'Idiopathic Pulmonary Fibrosis'. [Invited Lecture], Board Review, West Los Angeles VA , 04-MAY-06.
Keane, M.; (2005) 'Inflammation, microvascular changes, and lung remodeling in IPF: What Are the Implications for Effective Therapies?'. [Invited Lecture], ACCP, Montreal, Canada, Montreal, Canada , 31-OCT-05.
Keane, M.; (2005) CXC chemokines in pulmonary fibrosis associated with connective tissue disease. [Invited Lecture], 2nd Annual international rare lung disease conference, CT-ILD symposium, Cincinnati, OH , 09-APR-05.
Keane, M.; (2005) 'Interstitial lung disease'. [Invited Lecture], Pulmonary Grand Rounds, Cedars Sinai Medical Center, Cedars Sinai Medical Center, Los Angeles, CA , 09-MAR-05.
Keane, M.; (2004) 'Why we can't ignore the importance of inflammation in progression of fibrosis'. [Invited Lecture], ATS International Meeting, Orlando, FLA , 22-MAY-04.
Keane, M.; (2004) Visiting Professor, University of Southern California. [Invited Lecture], Visiting Professor, University of Southern California, University of Southern California, Los Angeles , 25-MAR-04.
Keane, M.; (2003) 'ICU Medicine'. [Invited Lecture], ACP, California Board Review, Universal City, Los Angeles , 09-JUL-03.
Keane, M.; (2003) 'Thromboembolic Disease'. [Invited Lecture], Tarzana Regional Medical Center, Tarzana, CA , 09-MAY-03.

Committees

Committee : American Lung Association of California Research Review Committee.
Committee : NIH, National Heart Lung and Blood, Special Review Committee, Mechanisms of Graft Versus Host Disease
Committee : American Lung Association of California Research Review Committee.
Committee : UCLA Rheumatic Disease Research Core Center, Pilot and feasibility grants review committee.
Committee : American Thoracic Society, Grant Awards Program, Scientific Advisory Committee.
Committee : Education committee, Division of Pulmonary and Critical Care Medicine, UCLA.
Committee : Interstitial Lung Disease Center, UCLA.
Committee : UCLA Medical Center Ethics Committee
Committee : UCLA Medical Center, Critical Care Committee
Committee : End of Life Committee, UCLA Medical Center

Employment

Employer: St Vincent¿s University Hospital, Dublin
Position: Consultant Respiratory Physician
Employer: UCLA Medical Center, Los Angeles, California
Position: Staff Physician
Employer: University of Michigan Medical Center, Ann Arbor, Michigan
Position: Staff Physician
Employer: Santa Monica Medical Center, Los Angeles, California
Position: Staff Physician
Employer: Veterans Affairs Medical Center, Ann Arbor, Michigan
Position: Staff Physician
Employer: University College Dublin.
Position: Professor of Medicine and Therapeutics, Chair of Medicine and Therapeutics
Employer: UCLA, Los Angeles, California
Position: Associate Professor, Division of Pulmonary and Critical Care Medicine
Employer: UCLA, Los Angeles, California.
Position: Assistant Professor, Division of Pulmonary and Critical Care Medicine
Employer: University of Michigan Medical Center, Ann Arbor, Michigan.
Position: Assistant Professor, Division of Pulmonary and Critical Care Medicine
Employer: University of Michigan Medical Center, Ann Arbor, Michigan
Position: Lecturer, Division of Pulmonary and Critical Care Medicine
Employer: University of Michigan Medical Center, Ann Arbor, Michigan
Position: Fellow, Division of Pulmonary and Critical Care Medicine,
Employer: Beaumont Hospital, Dublin; General/Respiratory Medicine
Position: Medical Registrar
Employer: James Connolly Memorial Hospital, Dublin; General Medicine and Gastroenterology
Position: Medical Registrar
Employer: Our Lady of Lourdes Hospital, Drogheda; St. Michael¿s Hospital, Dublin; Mater Hospital, Dublin
Position: Medical SHO
Employer: Mater Hospital, Dublin
Position: Medical/Surgical Intern

Education

Year 1989 Institution:
Qualification: MB, BCh, BAO Subject:
Year 2003 Institution:
Qualification: MD Subject:
 

Consultancy

Client: Centecor, Inc
Client: InterMune Pharmaceuticals
   

Other Activities

Reviewer
American Journal of Respiratory and Critical Care Medicine
Experimental Lung Research
European Respiratory Journal
American Journal of Physiology
American Journal of Pathology
American Journal of Respiratory Cell and Molecular Biology
Blood
British Journal of Pharmacology
Cellular Immunology
Respiratory Research
Arthritis and Rheumatism
Journal of Immunology
Expert Opinion on Drug Safety
Journal of Clinical Investigation
Respiration
Cancer Immunology Immunotherapy
Mayo Clinic Proceedings
Immunology
European Journal of Immunology
Expert Review in Clinical Immunology
Frontiers in Bioscience
Lung
Journal of Laboratory and Clinical Medicine
Future Oncology
Virology
External referee/examiner
6/26/06 Special Extern Examiner for the Senate of the National University of Ireland (Constituent University: NUI, Galway), MD examination.
9/06 External Referee for promotion to tenured position, Columbia University, New York.
10/06 External Referee, for promotion to tenured position University of Virginia, VA.

Publications

 

Book Chapters

Strieter RM, Belperio JA, Keane MP. ; (0) 'Cytokines and Chemokines in Lung Inflammation and Injury' In: Fishman¿s Pulmonary Diseases & Disorders, 4th Edition. New York: McGraw-Hill. [Details]
Keane MP, Belperio JA, Strieter RM. ; (0) 'Chemokines in Angiogenesis' In: Teicher BA and Ellis L (eds). Anti angiogenic agents in cancer therapy. *: Humana Press. [Details]
Belperio JA, Keane MP, Strieter RM. ; (0) 'The role of cytokines during the pathogenesis of ventilator associated and ventilator induced lung injury' In: *. NY: Marcel Decker Inc. [Details]
Keane MP, Belperio JA, Strieter RM. ; (0) 'Angiogenesis' In: Harrison JK and Lukacs NW (eds). The Chemokine Receptors. *: Humana Press. [Details]
Keane MP, Strieter RM. ; (0) 'Angiogenesis: major mechanisms of pulmonary angiogenesis, angiogenesis and cancer' In: Cagle, Barrios, Haque, Jagirdar, Popper and Zander, eds (eds). Molecular Pathology of Lung Diseases. *: *. [Details]
Keane MP, Strieter RM, Belperio JA. ; (2006) 'Macrophage Inflammatory Proteins (CCL3, CCL4, CCL9/10, CCL15, CCL18, CCL19, CCL20, CXCL2)' In: Laurent GJ and Shapiro SD (eds). Encyclopedia of Respiratory Medicine. Oxford: Elsevier Limited. [Details]
Keane MP, Belperio JA, Strieter RM. ; (2006) 'Chemokines , CXC: IL-8 (CXCL8)' In: Laurent GJ and Shapiro SD (eds). Encyclopedia of Respiratory Medicine. Oxford: Elsevier Limited. [Details]
Keane MP, Strieter RM. ; (2006) 'Chemokines, CC: C10 (CCL6)' In: Laurent GJ and Shapiro SD (eds). Encyclopedia of Respiratory Medicine. Oxford: Elsevier Limited. [Details]
Strieter RM, Burdick MD, Sakkour A, Arnaiz NO, Belperio JA, Keane MP; (2005) 'CXC chemokines in cancer' In: Schwiebert L (eds). Chemokines Chemokine Receptors and Disease. Current topics in Membranes Vol 55. San Diego, CA: Elsevier Inc. Science & Technology/Academic Press. [Details]
Keane MP, Belperio JA, Strieter RM. ; (2005) 'Mediators and inflammatory cell recruitment in acute lung injury' In: RH Notter, JH Finklestein, BA Holm (eds). Lung Injury Mechanisms, Pathophysiology and Therapy. Boca Raton, FL: Taylor & Francis Group. [Details]
Keane MP, Belperio JA, Henson PM, Strieter RM. ; (2005) 'Inflammation, injury and repair' In: Murray, Nadel et. al (eds). Textbook of Respiratory Medicine. Saunders, Philadelphia: Elsevier. [Details]
Deng J, Keane MP, Lynch JP. ; (2004) 'Pulmonary interstitial lung disease in polymyositis and dermatomyositis' In: A Wells and C Denton (eds). Handbook of systemic autoimmune diseases: pulmonary involvement in systemic autoimmune disease. Amsterdam: Elsevier Science. [Details]
Keane MP, Belperio JA, Strieter RM. ; (2004) 'Endothelin, angiogenesis and pulmonary fibrosis' In: Clozel M and Rubin LJ (eds). Endothelin in cardiopulmonary disease. Basel Switzerland: Friedrich Reinhardt Verlag. [Details]
Keane MP, Belperio JA, Strieter RM. ; (2003) 'Cytokine biology and the pathogenesis of interstitial lung disease' In: Schwarz MI & TE King (eds). Interstitial Lung Disease. Hamilton, Ontario, Canada: B.C. Decker, Inc. [Details]
Strieter RM, Burdick MD, Beleprio JA, Keane MP; (2003) 'Methods to measure chemokines at the protein level in tissue' In: DiPietro LA and Burns-Harring AL (eds). Methods in Molecular Medicine, vol 78: Wound Healing: Methods and Protocols. Totowa, NJ: The Humana Press, Inc. [Details]
Keane MP, Belperio JA, Strieter RM. ; (2003) 'Chemokines in Pulmonary Fibrosis' In: Strieter RM, Kunkel SL, Standiford TJ, Lenfant C (eds). Chemokines in the Lung, Lung Biology in Health and Disease, Vol 172. New York, NY: Marcel Decker. [Details]
Belperio JA, Keane MP, Strieter RM. ; (2003) 'Chemokines in Lung Transplantation' In: Strieter RM, Kunkel SL, Standiford TJ, Lenfant C (eds). Chemokines in the Lung. Lung Biology in Health and Disease. New York: Marcel Decker. [Details]
Strieter RM, Belperio JA, Dubinett SM, Keane MP. ; (2003) 'Chemokines in Lung Cancer' In: Strieter RM, Kunkel SL, Standiford TJ, Lenfant C (eds). Chemokines in the Lung. Lung Biology in Health and Disease, Vol 172. New York, NY: Marcel Decker. [Details]
Strieter RM, Belperio JB, Keane MP. ; (0) 'CXC chemokines in angiogenesis related to pulmonary fibrosis' In: Lynch JP (eds). Idiopathic Pulmonary Fibrosis. New York: Marcel Decker. [Details]
 

Peer Reviewed Journals

O'Neill AC, McCarthy C, Ridge CA, Mitchell P, Hanrahan E, Butler M, Keane MP, Dodd JD; (2011) 'Rapid Needle-Out Patient-Rollover Time after Percutaneous CT-guided Transthoracic Biopsy of Lung Nodules: Effect on Pneumothorax Rate'. Radiology, . [DOI] [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
O'Beirne S, Counihan IP, Keane MP; (2010) 'Interstitial lung disease and lung transplantation'. Critical Care Medicine, 31 (2):139-146. [DOI] [Details]
Kelly E, Mhurchu EN, Sukor S, McDonnell TJ, Tryfonopoulos D, Keane MP; (2010) 'Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis'. Respiratory care, 55 (11):1491-1494. [Details]
Huynh TN, Weigt SS, Belperio JA, Territo M, Keane MP; (2009) 'Outcome and prognostic indicators of patients with hematopoietic stem cell transplants admitted to the intensive care unit'. Journal of transplantation, 2009 . [DOI] [Details]
Belperio JA, Weigt SS, Elashoff RM, Huang C, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Keane MP, Saggar R, Lynch JP 3rd, Zisman DA, Ross DJ, ; (2009) 'Aspergillus colonization of the lung allograft is a risk factor for bronchiolitis obliterans syndrome'. American Journal of Transplantation, 9 (8):1903-1911. [DOI] [Details]
Belperio JA, Busuttil A, Weigt SS, Keane MP, Xue YY, Palchevskiy V, Burdick MD, Huang C, Zisman DA, Fishbein M, Lynch JP 3rd, Strieter RM, Elashoff RM, ; (2009) 'CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis'. EUR RESPIR J, 34 (3):676-686. [DOI] [Details]
King, R.,Stenke, E.,Kelly, E.,McDermott, S.,Hickey, C.,Murphy, K.,Tubridy, N.,Keane, M. P.; (2009) 'Recurrent malaise and oedema in a 35-year-old female'. Intensive Care Med, 35 (7):1314-5. Available Online [Details]
Weigt, S. S., Elashoff, R. M., Keane, M. P., Strieter, R. M., Gomperts, B. N., Xue, Y. Y., Ardehali, A., Gregson, A. L., Kubak, B., Fishbein, M. C., Saggar, R., Ross, D. J., Ill, J. P. L., Zisman, D. A., Belperio, J. A., ; (2008) 'Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation'. American Journal of Transplantation, 8 (7):1512-1522. [Details]
Saggar, R., Ross, D. J., Zisman, D. A., Gregson, A., Lynch, J. P., Keane, M. P., Weigt, S. S., Ardehali, A., Kubak, B., Lai, C., Elashoff, D., Fishbein, M. C., Wallace, W. D., Belperio, J. A., ; (2008) 'Pulmonary hypertension associated with lung transplantation obliterative bronchiolitis and vascular remodeling of the allograft'. American Journal of Transplantation, 8 (9):1921-1930. [Details]
Weigt, S. S., Huang, C., Keane, M. P., Xue, Y. Y., Palchevskiy, V., Ardebali, A., Gregson, A. L., Kubak, B., Saggar, R., Ross, D. J., Lynch, J. P., Elasboff, R. M., Belperio, J. A., ; (2008) 'The impact of aspergillus infection on survival and bronchiolitis obliterans syndrome in lung transplantation'. Journal of Heart and Lung Transplantation, 27 (2):90-91. [Details]
Huynh, T. N., Weigt, S. S., Territo, M., Keane, M. P., ; (2007) 'Mortality and prognostic factors of patients with hematopoietic stem cell transplants admitted to the intenswe care unit'. Critical Care Medicine, 35 (12):8-8. [Details]
Keane, MP, Donnelly, SC, Belperio, JA, Goodman, RB, Dy, M, Burdick, MD, Fishbein, MC, Strieter, RM, ; (2002) 'Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome'. J IMMUNOL, 169 (11):6515-6521. [Details]
Zisman DA, Karlamangla AS, Ross DJ, Keane MP, Belperio JA, Saggar R, Lynch JP 3rd, Ardehali J, Goldin J. ; (2007) 'High resolution chest computed tomography findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis'. Chest, 132 (3):773-779. [Details]
Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM. ; (2007) 'Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferators activated receptor-gamma'. Journal of Biological Chemistry, 282 (31):22910-22920. [Details]
Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM. ; (2007) 'Keratinocyte growth factor improves airway repair in injured tracheal epithelium'. American Journal of Respiratory Cellular Molecular Biol, 37 (1):48-56. [Details]
Strieter RM, GompertS BN, Keane MP. ; (2007) 'The role of CXC chemokines in pulmonary fibrosis'. Journal of Clinical Investigation, 117 (3):549-556. [Details]
Mehrad B, Keane MP, Strieter RM. ; (2007) 'Chemokines as mediators of angiogenesis'. Thrombosis and Haemostasis, 97 (5):755-762. [Details]
Mohsenin A, Burdick MD, Molina JG, Keane MP, Blackburn MR. ; (2007) 'Adenosine mediated CXCL1 production and angiogenesis in the lung'. Faseb Journal, 21 (4):1026-1036. [Details]
Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman D, Ardehali A, Saggar R, Lynch JP, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA. ; (2007) 'IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome'. Journal of Immunology, 178 (1):511-519. [Details]
Mehrad B, Burdick B, Zisman DA, Keane MP, Belperio JA, Strieter RM. ; (2007) 'Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease'. Biochemical and Biophysical Research Communications, 353 (1):104-108. [Details]
Martinez FJ, Keane MP. ; (2006) 'Update in diffuse parenchymal lung disease 2005'. American Journal of Respiratory and Critical Care Medic, 173 (10):1066-1071. [Details]
Belperio JA, Keane MP, Lynch JP, Strieter RM. ; (2006) 'The role of cytokines in ventilator associated and ventilator induced lung injury'. Seminars in Respiratory and Critical Care Medicine, 27 (4):350-364. [Details]
Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, Torday JS. ; (2006) 'Evidence for the presence of lipofibroblasts in the human lung'. Experimental Lung Research, 32 (8):379-393. [Details]
Keane MP, Strieter RM, Lynch JP, Belperio JA. ; (2006) 'Inflammation and angiogenesis in fibrotic lung disease'. Seminars in Respiratory and Critical Care Medicine, 27 (6):589-599. [Details]
Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, ; (2006) 'Cancer CXC chemokine networks and tumor angiogenesis'. European Journal of Cancer, 42 (6):768-778. [Details]
Wente MN, Keane MP, Burdick MD, Friess H, Büchler MW, Ceyhan CO, Reber HA, Strieter RM, Hines OJ. ; (2006) 'Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis'. Cancer Letters, 241 (2):221-227. [Details]
Belperio JA, Keane MP, Burdick MD, Gomperts BN, Xue YY, Hong K, Mestas J, Zisman D, Ardehali A, Saggar R, Lynch JP, Ross DJ, Strieter RM. ; (2005) 'CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury'. Journal of Immunology, 175 (10):6391-6399. [Details]
Zisman DA, Keane MP, Belperio JA, Strieter RM, Lynch JP; (2005) 'Pulmonary Fibrosis'. Methods in Molecular Medicine, 117 :3-44. [Details]
Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM. ; (2005) 'CXCR2 is critical for dsRNA induced lung injury: relevance to viral lung infection'. Journal of Inflammation, 2 (1). [Details]
Strieter RM, Belperio JA, Burdick MD, Keane MP. ; (2005) 'CXC chemokines in angiogenesis relevant to fibroproliferation'. Current Drug Targets - Inflammation & Allergy, 4 (1):23-26. [Details]
Strieter RM, Keane MP, Burdick MD, Sakkour A, Murray LA, Belperio JA. ; (2005) 'The Role of CXCR2/CXCR2 ligands in acute lung injury'. Current Drug Targets - Inflammation & Allergy, 4 (3):299-303. [Details]
Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP; (2005) 'CXC Chemokines in Angiogenesis'. Cytokine & Growth Factor Reviews, 16 (6):593-609. [Details]
Londhe V, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM. ; (2005) 'CXCR2/CXCR2 ligand biological axis impairs alveologenesis during dsRNA induced lung inflammation in mice'. Paediatric Research, 58 (5):919-926. [Details]
Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K, Mestas J, Ardehali A, Mehrad B, Saggar R, Lynch JP III, Ross DJ, Strieter RM. ; (2005) 'Role of CXCR2/CXCR2 ligands in vascular remodeling during the pathogenesis of bronchiolitis obliterans syndrome: The role of CXC chemokines'. Journal of Clinical Investigation, 115 (5):1150-1162. [Details]
Keane MP, Strieter RM, Belperio JA. ; (2005) 'Mechanisms and mediators of pulmonary fibrosis'. Critical Reviews in Immunology, 25 (6):429-463. [Details]
Burdick MD, Murray LA, Keane MP, Xue YY, Zisman DA, Belperio JA, Strieter RM. ; (2005) 'CXCL11 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Vascular Remodeling'. American Journal of Respiratory and Critical Care Medic, 171 (3):261-268. [Details]
Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM. ; (2005) 'EGF and hypoxia-induced expression of CXCR4 on non-small cell lung cancer cells is regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1'. Journal of Biological Chemistry, 280 (23):22473-22481. [Details]
Strieter RM, Belperio JA, Burdick MD, Sharma S, Dubinett SM, Keane MP. ; (2004) 'CXC chemokines: angiogenesis, immunoangiostasis and metastases in lung cancer'. Annals of the New York Academy of Science, 1028 :351-356. [Details]
Strieter RM, Belperio JA, Philips RJ, Keane MP. ; (2004) 'Chemokines: Angiogenesis and metastases in lung cancer'. Novartis Foundation Symposium, 256 :173-184. [Details]
Strieter RM, Belperio JA, Phillips RJ, Keane MP. ; (2004) 'CXC Chemokines in angiogenesis of cancer'. Seminars in Cancer Biology, 14 (3):195-200. [Details]
Gabazza EC, Kasper M, Ohta K, Keane M, D'Alessandro-Gabazza C, Fujimoto H, Nishii Y, Nakahara H, Takagi T, Menon AG, Adachi Y, Suzuki K, Taguchi O. ; (2004) 'Decreased expression of auaporin-5 in bleomycin-induced lung fibrosis in the mouse'. Pathology International, 54 :774-780. [Details]
Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. ; (2004) 'Depletion of CXCR2 inhibits tumor growth and metastases in a murine model of lung cancer'. Journal of Immunology, 172 :2853-2860. [Details]
Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Londhe VA, Keane MP, Strieter RM. ; (2004) 'CXCR2 is critical to hyperoxia induced lung injury'. Journal of Immunology, 172 :3860-3868. [Details]
Brown-Saltzman K, Diamant A, Fineberg IC, Gritsch HA, Keane M, Korenmann S, Lewis M, Morgan M, Rothenberg L, Tymchuk A, Weiss F, Weiss I, Wenger N, Wiley UCLA Medical Center Ethics Committee, UCLA Renal Transplant Program. ; (2004) 'Surrogate consent for living related organ donation'. Journal of the American Medical Association, 291 (6):728-731. [Details]
Strieter R, Starko K, Enelow R, Noth I, Valentine V and members of the Idiopathic Pulmonary Fibrosis biomarkers study group (including Keane MP). ; (2004) 'Effects of Interferon gamma-1b on biomarkers in patients with idiopathic pulmonary fibrosis: a randomized, double blind study'. American Journal of Respiratory and Critical Care Medic, 170 (2):133-140. [Details]
Huang M, Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, Dubinett SM. ; (2004) 'PKC-plays a critical role in the regulation of collagen synthesis in pulmonary fibrosis'. Journal of Biological Chemistry, 279 (27):28315-28319. [Details]
Keane MP. ; (2004) 'Angiogenesis and pulmonary fibrosis: feast or famine'. American Journal of Respiratory and Critical Care Medic, 170 (3):207-209. [Details]
Phillips RJ, Burdick MD, Lutz M, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. ; (2004) 'Circulating fibrocytes traffic to the lung in response to CXCL12 and mediate fibrosis'. European Journal of Clinical Investigation, 114 (3):438-446. [Details]
Belperio JA, Dy MC, Murray L, Burdick MD, Xue YY, Strieter RM, Keane MP. ; (2004) 'The role of the Th2 chemokine CCL17 in pulmonary fibrosis'. Journal of Immunology, 173 (7):4692-4698. [Details]
Strieter RM, Keane MP. ; (2004) 'Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis'. Journal of Clinical Investigation, 114 (2):165-168. [Details]
Keane MP. ; (2004) 'Chemokine profiling in pulmonary fibrosis: ready for prime time?'. American Journal of Respiratory and Critical Care Medic, 170 (5):474-476. [Details]
Belperio JA, Keane MP, Burdick MD, Lynch JP III, Xue YY, Li K, Ross DJ, Strieter RM. ; (2003) 'Critical role for MIG/CXCR3 chemokine biology in the pathogenesis of acute lung allograft rejection'. Journal of Immunology, 171 :4844-4852. [Details]
Strieter RM, Belperio JA, Keane MP; (2003) 'Host innate defenses in the lung, the role of cytokines'. Current Opinion in Infectious Diseases, 16 (3):193-198. [Details]
Belperio JA, Lake K, Tazelaar H, Keane MP, Strieter RM, Lynch JP; (2003) 'Bronchiolitis obliterans complicating lung or heart-lung transplantation'. Seminars in Respiratory and Critical Care Medicine, 24 :499-529. [Details]
Jakubzik C, Choi ES, Joshi BH, Keane MP, Kunkel SL, Puri RK, Hogaboam CM. ; (2003) 'Reversal of pulmonary fibrosis via targeting of IL-4 and IL-13 responsive cells'. Journal of Immunology, 171 :2684-2693. [Details]
Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. ; (2003) 'The SDF-1/CXCL12/CXCR4 biological axis in non small cell lung cancer metastases. Am J Resp Crit Care Med 167: 1676-1686, 2003'. American Journal of Respiratory and Critical Care Medic, 167 :1676-1686. [Details]
Belperio JA, Keane MP, Strieter RM. ; (2003) 'The role for chemokine/chemokine receptors in the pathogenesis of lung allograft rejection'. Current Opinion in Organ Transplantation, 8 :40-49. [Details]
Huang M, Sharma S, Zhu LX, Keane MP, Luo J, Zhang L, Burdick MD, Lin YQ, Dohadwala M, Gardner B, Batra RK, Strieter RM, Dubinett SM. ; (2002) 'Interleukin-7 inhibits both TGF- production and signaling in pulmonary fibrosis fibroblasts'. Journal of Clinical Investigation, 109 :931-937. [Details]
Belperio JA, Burdick MD, Xu YY, Li K, Elias JA, Keane MP. ; (2002) 'Interaction of IL-13 and C10 in the pathogenesis of bleomycin induced pulmonary fibrosis'. American Journal of Respiratory Cellular Molecular Biol, 27 :419-427. [Details]
Belperio JA, Keane MP, Burdick MD, Lynch III JP, Xue YY, Li K, Ross DJ, Strieter RM. ; (2002) 'Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome'. Journal of Immunology, 169 :1037-1049. [Details]
Keane MP, Strieter RM. ; (2002) 'The importance of balanced pro and anti inflammatory mechanisms in diffuse lung disease'. Respiratory Research, 3 (5). [Details]
Belperio JA, DiGiovine B, Keane MP, Burdick MD, Xue YY, Lynch III JP, Kunkel SL, Strieter RM. ; (2002) 'Iinterleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients'. Transplantation, 73 :591-599. [Details]
Belperio JA, Keane MP, Burdick MD, Lynch III JP, Xue YY, Li K, Ross DJ, Strieter RM. ; (2002) 'Critical role for CXCR2 chemokine biology in the pathogenesis of ventilator induced lung injury'. Journal of Clinical Investigation, 110 :1703-1716. [Details]
Strieter RM, Belperio JA, Keane MP. ; (2002) 'CXC chemokines in angiogenesis related to pulmonary fibrosis'. Chest, 122 :298S-301S. [Details]
Strieter RM, Belperio JA, Keane MP. ; (2002) 'Cytokines in innate host defense in the lung'. Journal of Clinical Investigation, 109 :699-705. [Details]
 

Conference Publications

Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P; (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society International Conference [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
                       

Abstract

Phillips RJ, Mestas J, Burdick MD, Belperio JA, Keane MP, Strieter RM. ; (2005) Impaired PTEN in non-small cell lung cancer (NSCLC) is correlated with expression of HIF-1, CXCR4 and metastases. Abstract [Details]
Belperio JA, Keane MP, Burdick MD, Lynch JP, Gomperts B, Ardehali A, Ross DJ, Lukacs NW, Strieter RM. ; (2005) The role of IL-13 cytokine biology during the pathogenesis of bronchiolitis obliterans syndrome. Abstract [Details]
Belperio JA, Imura M, Dy M, Xue YY, Philips RJ, Burdick MD, Strieter RM, Keane MP. ; (2005) The role of STAT 6 in pulmonary fibrosis. Abstract [Details]
Zisman DA, Lynch JP, Strieter RM, Saggar R, Keane MP, Belperio JA, Ardehali A, Ross DJ. ; (2005) Pulmonary arterial hypertension is common in patients with idiopathic pulmonary fibrosis (IPF/UIP) referred for lung transplantation. Abstract [Details]
Keane MP, Belperio JA, Dy M, Murray L, Xue YY, Burdick MD, Lynch JP, Zisman DA, Clozel M, Strieter RM. ; (2004) Bosentan inhibits bleomycin induced pulmonary fibrosis. Abstract [Details]
Belperio JA, Keane MP, Burdick MD, Ross DJ, Ardehali A, Kwon JJG, Lynch JP, Xue YY, Strieter RM. ; (2004) KC/CXCL11 and MIP-2/CXCL2/3 interactions with CXCR2 are associated with Bronchiolitis Obliterans Syndrome. Abstract [Details]
Phillips RJ, Murray LA, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. ; (2004) Circulating CD45+ Col1+CXCR4+ Progenitor Fibrocytes traffic to the lung in response to CXCL12 and mediate pulmonary fibrosis. Abstract [Details]
Saggar R, Zisman DA, Kleerup EC, Tashkin DP, Keane MP, Belperio JA, Strieter RM, Zeidler MR. ; (2004) Elevated levels of exhaled NO in Idiopathic Pulmonary Fibrosis. Abstract [Details]
Murray LA, Keane MP, Burdick MD, Sue RD, Xue RD, Xue YY, Zisman DA, Belperio JA, Strieter RM. ; (2004) Systemic CXCL11 treatment inhibits bleomycin induced pulmonary fibrosis by reducing angiogenic activity. Abstract [Details]
Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Kwon JJ, Strieter RM. ; (2004) Increased MIG/CXCL9 and IP-10/CXCL10 in virus induced lung inflammation: A prelude to Bronchopulmonary Dysplasia. Abstract [Details]
*; (2003) 61. The role for KC/CXCL1 and MIP-2/CXCL2/3 in the pathogenesis of lung transplantation ischemia reperfusion injury. Abstract [Details]
Sue RD, Keane MP, Belperio JA, Burdick MD, Xue YY, Strieter RM. ; (2003) Elevated levels of KC/CXCL1 and MIP-2/CXCL2/3 are associated with hyperoxia-induced lung injury. Abstract [Details]
Sue RD, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM; (2003) Variable concentrations of hyperoxia contribute to sepsis induced acute lung injury in a dose dependent fashion. Abstract [Details]
Belperio JA, Dy M, Burdick MD, Xue YY, Li K, Strieter RM, Keane MP. ; (2003) The role of the TH2 chemokines MDC and TARC in pulmonary fibrosis. Abstract [Details]
Londhe,VA., Belperio JA, Keane MP, Burdick MD, Devasker SU, Strieter RM. ; (2003) Chemokine biology in virus-induced lung inflammation a prelude to bronchopulmonary dysplasia. Abstract [Details]
Belperio JA, Dy M, Burdick MD, Xue YY, Li K, Strieter RM, Keane MP. ; (2003) The role of the TH2 chemokines MDC and TARC in pulmonary fibrosis. Abstract [Details]
Zhang L, Keane MP, Zhu LX, Sharma S, Batra RK, Strieter RM, Dubinett SM, Huang M. ; (2003) The Role of PKC-in the Cross-talk Between IL-7 and TGF-Signaling Pathways in Pulmonary Fibrosis Fibroblasts. Abstract [Details]
Londhe,VA., Belperio JA, Keane MP, Burdick MD, Strieter RM; (2003) Chemokine biology in virus-induced lung inflammation a prelude to bronchopulmonary dysplasia. Abstract [Details]
Belperio JA, Keane MP, Burdick MD, Addison CA, Lynch JP III, Londhe V, Xue YY, Ardehali A, Ross DJ, Strieter RM. ; (2003) Role for IL-10 cytokine biology in the pathogenesis of acute lung allograft rejection. Abstract [Details]
Sue RD, Murray LA, Belperio JA, Burdick MD, Xue YY, Kwon JJ, Keane MP, Strieter RM. ; (2003) Hyperoxia induced acute lung injury is mediated by an imbalance between CXCR2 and CXCR3 receptor and ligand expression. Abstract [Details]
Belperio JA, Keane MP, Burdick MD, Lynch JP III, Xue YY, Li K, Ross DJ, Strieter RM. ; (2002) Critical role for MIG/CXCR3 chemokine biology in the pathogenesis of acute lung allograft rejection. Abstract [Details]
Zhang L, Sharma S, Batra RK, Keane MP, Strieter RM, Dubinett SM, Huang H. ; (2002) Interleukin-7 inhibits TGF- signaling in pulmonary fibrosis fibroblasts by a Smad 7-dependent pathway. Abstract [Details]
Belperio JA, Keane MP, Burdick MD, Lynch JP III, Xue YY, Li K, Strieter RM; (2002) Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Abstract [Details]
Keane MP, Donnelly SC, Belperio JA, Goodman R, Burdick MD, Strieter RM; (2002) IL-8 correlates with BALF angiogenic activity and pro-collagen levels in ARDS. Abstract [Details]
                                                               

Research

Research Interests

GRANT SUPPORT
Current

SFI PI Award, Principal Investigator, IL-13 receptor in lung injury and remodelling. ¿1,206,361 direct costs 

Recent
NIH RO1 HL080206, Co-Investigator, The role of chemokines during lung allograft rejection. 8/1/05-7/31/09. $1,250,000 direct costs

NIH RO1 AR055075, Principal Investigator, Cytokines as predictors of disease progression in scleroderma lung disease. 9/1/06-8/31/10. $880,000 direct costs (Tansferrred to another PI upon my leaving UCLA)

NIH P50 HL67655 Principal investigator, Project 2 (35% effort), TH2 cytokines and CC chemokines in Pulmonary Fibrosis, 9/1/01-8/31/06 ($904,902 direct costs).

Sunol Molecular Corporation, Principal Investigator, The safety, Pharmacokinetics and Physiological Effects of Sunol-cH36 in patients with acute lung injury/acute respiratory distress syndrome. 2/1/2005-1/31/2007.

NIH KO8 HL03906, Principal Investigator (80% effort), "Chemokines regulate angiogenesis in pulmonary fibrosis"; 2/1/99-1/31/2004 ($620,000 direct costs)

Council on Research of the Academic Senate at UCLA, Assistant Professor Initiative, "CC chemokines and TH2 cytokines in Pulmonary Fibrosis", 11/1/00-6/30/01 ($2,000)

American Lung Association Dalsemer Research Scholar Award, "TH2 cytokines and CC chemokines in Pulmonary Fibrosis", 7/1/01-6/30/03 ($49, 970).


Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Glaxo Respiratory Research
Start Date / End Date : 01-AUG-10 / 31-JUL-11
Sponsor : Health Research Board (HRB)
Title : The Effect of Mesenchymal Stem Cells on Pulmonary Fibrosis
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : Science Foundation Ireland (SFI)
Title : IL-13 receptor in lung injury and remodelling
Start Date / End Date : 01-SEP-08 / 31-AUG-12
Sponsor : UCD School of Medicine and Medical Science
Title : Start -Up Funds
Start Date / End Date : 01-OCT-07 / 30-SEP-14