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Researchers at UCD

researcher

Paul McLoughlin

Conway Fellow

Conway Institute of Biomolecular & Biomedical Research

Tel: 353 1 716 6776
Email: paul.mcloughlin@ucd.ie

Biography

POSITIONS HELD

2004-present  Professor of Physiology, UCD
1998-2004      Associate Professor of Physiology, UCD
1996-1998 Statutory (Senior) Lecturer in Physiology, UCD
1993-1996 Lecturer in Physiology, UCD
1992-1993 Postgraduate Medical Training
1989-1993 Wellcome Research Fellow, UMDS, University of London
1987-1989 Lecturer in Medicine, Trinity College Dublin
1985-1987 Postgraduate Medical Training Dublin Hospitals
1984-1985 Medical Demonstrator, Physiology UCD
1983-1984 Postgraduate Medical Training St Vincent's University Hospital, Dublin



EDUCATION

1993 PhD, University of London
1987 Member Royal College of Physicians in Ireland
1985 BSc Physiology (Hons) University College Dublin
1983 MB BCh, BAO (Hons) University College Dublin

Professional

             

Employment

Employer: St. Thomas's Hospital / University of London
Position: Wellcome Trust Research Fellow
Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: Statutory Lecturer
Employer: Univerity College Dublin
Position: Honorary Lecturer
Employer: University College Dublin
Position: Associate Professor

Education

Year 1983 Institution: University of Auckland, NZ
Qualification: MB, BCh, BAO Subject:
Year 1985 Institution: University College Dublin
Qualification: BSc Subject:
Year 1992 Institution:
Qualification: PhD Subject:
Year 1986 Institution: Royal College of Physicians in Ireland
Qualification: MRCPI Subject: Medicine
         

Publications

 

Book Chapters

Butler, M McLoughlin, P Keane, M (2014) 'Chemokines, Adipokines, and Growth Factors in the Lung' In: Grippi, M Elias, J Fishman, J Pack, A Senior, R Kotloff, R (eds). Fishman's Pulmonary Diseases and Disorders. Philadelphia: McGraw-Hill. [Details]
Paul McLoughlin, Michael P. Keane; (2011) 'Physiological and Pathological Angiogenesis in the Adult Pulmonary Circulation' In: I. F. McMurtry, W. W. Wagner, T. Stevens, M. N. Gillespie (eds). Comprehensive Physiology. Hoboken, NJ, USA: Wiley Blackwell. , pp.1473-1508 Available Online [DOI] [Details]
 

Peer Reviewed Journals

Rowan, S. C. McLoughlin, P (2014) 'Hypoxic pulmonary hypertension: the paradigm is changing'. Experimental Physiology, 99 (6):837-838. [Details]
D Ryan S Frohlich P McLoughlin (2014) 'Pulmonary vascular dysfunction in ARDS'. Annals of intensive care, 4 (28). Available Online [DOI] [Details]
Fröhlich S, Boylan J, McLoughlin P (2013) 'Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?'. American Journal of Respiratory Cell and Molecular Biology, 48 (3):271-279. [Details]
Lili Li*, Katherine Howell*, Michelle Sands, Mark Banahan, Stephen Frohlich, Simon C Rowan, Roisín Neary, Donal Ryan, Paul McLoughlin (2013) 'The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance'. PLoS ONE, . [Details]
McLoughlin P, Ward JP (2013) 'Hypoxic pulmonary hypertension; the load on the right ventricle'. Experimental Physiology, 98 (8):1244-1246. [Details]
Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P; (2012) 'The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally'. Experimental Physiology, . [DOI] [Details]
Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC. (2012) 'Macrophage Migration Inhibitory Factor Enzymatic Activity, Lung Inflammation and Cystic Fibrosis'. American Journal of Respiratory and Critical Care Medicine, . Available Online [Details]
Oliver KM, Lenihan CR, Bruning U, Cheong A, Laffey JG, McLoughlin P, Taylor CT, Cummins EP; (2012) 'Hypercapnia induces cleavage and nuclear localization of REL B giving insight into co2 sensing and signalling'. Journal of Biological Chemistry, . [DOI] Link to full text [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, 125 (7):920-930. [DOI] Link to full text [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
Sands, M,Howell, K,Costello, CM,McLoughlin, P; (2011) 'Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung'. Respiratory research, 12 . [DOI] [Details]
McLoughlin P, Costello CM, Cahill E, Martin F, Gaine S, ; (2010) 'Role of Gremlin in the Lung: Development and Disease'. American Journal of Respiratory Cell and Molecular Biology, 42 (5):517-523. [DOI] [Details]
Cummins, EP,Oliver, KM,Lenihan, CR,Fitzpatrick, SF,Bruning, U,Scholz, CC,Slattery, C,Leonard, MO,McLoughlin, P,Taylor, CT; (2010) 'NF-kappa B Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells'. Journal of Immunology, 185 :4439-4445. [DOI] [Details]
Nichol, AD,O'Cronin, DF,Naughton, F,Hopkins, N,Boylan, J,McLoughlin, P; (2010) 'Hypercapnic Acidosis Reduces Oxidative Reactions in Endotoxin-induced Lung Injury'. Anesthesiology, 113 :116-125. [DOI] [Details]
Cummins EP, Oliver KM, Lenihan CR, Fitzpatrick SF, Bruning U, Scholz CC, Slattery C, Leonard MO, McLoughlin P, Taylor CT.; (2010) 'NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells'. Journal of Immunology, 185 (7):4439-4445. Available Online [DOI] [Details]
Hsia CC, Hyde DM, Ochs M, Weibel ER on behalf of ATS/ERS Joint Task Force on Quantitative Assessment of Lung Structure.; (2010) 'An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure'. American Journal of Respiratory and Critical Care Medicine, 181 (4):394-418. [DOI] [Details]
Nichol AD, O'Cronin D F, Naughton F, Hopkins N, Boylan J, McLoughlin P.; (2010) 'Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury'. Anesthesiology, 113 (1):116-125. [DOI] [Details]
Nichol, AD,O'Cronin, DF,Howell, K,Naughton, F,O'Brien, S,Boylan, J,O'Connor, C,O'Toole, D,Laffey, JG,McLoughlin, P; (2009) 'Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis'. Critical Care Medicine, 37 :2953-2961. [DOI] [Details]
Howell, K,Costello, CM,Sands, M,Dooley, I,McLoughlin, P; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. American journal of physiology. Lung cellular and molecular physiology, 296 (NA):1042-1050. [DOI] [Details]
C Costello, K Howell, E Cahill, J McBryan, M Konigshoff, O Eickelberg, S Gaine, F Martin, P McLoughlin; (2008) 'Lung Selective Gene Responses to Alveolar Hypoxia: Potential Role for the Bone Morphogenetic Antagonist Gremlin in Pulmonary Hypertension'. American Journal of Physiology - Lung Cellular and Molecular Physiology, 295 (2):L272-L284. Available Online [DOI] [Details]
O'Croinin, D. F., Nichol, A. D., Hopkins, N., Boylan, J., O'Brien, S., O'Connor, C., Laffey, J. G., McLoughlin, P., ; (2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'. Critical Care Medicine, 36 (7):2128-2135. [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, 178 (9):977-983. Available Online [DOI] [Details]
McLoughlin P, McMurtry I; (2007) 'Counterpoint: Chronic Hypoxia-induced Pulmonary Hypertension does not Lead to Loss of Pulmonary Vasculature'. Journal of Applied Physiology, 103 (4):1451-1453. [Details]
Foley, S. C.,Hopkins, N. O.,Fitzgerald, M. X.,Donnelly, S. C.,McLoughlin, P.; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respir Med, 101 (7):1549-1555. [Details]
McLoughlin, P.,McMurtry, I.; (2007) 'Last Word on Point:Counterpoint "Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature"'. J Appl Physiol, 103 (4). [Details]
Tsuchida, S, Engelberts, D, Peltekova, V, Hopkins, N, Frndova, H, Babyn, P, McKerlie, C, Post, M, McLoughlin, P, Kavanagh, BP, ; (2006) 'Atelectasis causes alveolar injury in nonatelectatic lung regions'. American Journal of Respiratory and Critical Care Medicine, 174 (3):279-289. [Details]
Hopkins, N,Gunning, Y,O'Croinin, DF,Laffey, J,McLoughlin, P; (2006) 'Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection'. Journal of Pathology, 209 :198-205. [DOI] [Details]
Thin, AG; Kelly, GE; Daly, L; McLoughlin, P; ; (2005) 'Repeated measurement of the gas exchange threshold: relative size of measurement and biological variabilities'. Computers in Biology and Medicine, 35 (8):703-716. [Details]
Thin, AG; Kelly, GE; Daly, L; McLoughlin, P; ; (2005) 'Repeated measurement of the gas exchange threshold: relative size of measurement and biological variabilities'. Computers in Biology and Medicine, 35 (8):703-716. [Details]
McLoughlin P, Hyvelin JM, Howell K.; (2005) 'Pulmonary hypertension'. New England Journal of Medicine, 352 (4):418-419. [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. [Details]
Cleary, C; Buckley, CH; Henry, E; McLoughlin, P; O'Brien, C; Hadoke, PWF; ; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 (2):223-228. [Details]
O'Croinin, DF; Hopkins, NO; Moore, MM; Boylan, JF; McLoughlin, P; Laffey, JG; ; (2005) 'Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury'. Critical Care Medicine, 33 (11):2606-2612. [Details]
Laffey, JG; O'Croinin, D; McLoughlin, P; Kavanagh, BP; ; (2004) 'Permissive hypercapnia - role in protective lung ventilatory strategies'. Intensive Care Medicine, 30 (3):347-356. [Details]
Thin, AG,Dodd, JD,Gallagher, CG,Fitzgerald, MX,McLoughlin, P; (2004) 'Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis'. Respiratory Medicine, 98 :1063-1070. [DOI] [Details]
McLoughlin P, Howell K, Ooi H, Preston R, ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Laffey, JG; Honan, D; Hopkins, N; Hyvelin, JM; Boylan, JF; McLoughlin, P; ; (2004) 'Hypercapnic acidosis attenuates endotoxin-induced acute lung injury'. American Journal of Respiratory and Critical Care Medicine, 169 (1):46-56. [Details]
Howell, K; Ooi, H; Preston, R; McLoughlin, P; ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Varadarajan, R; Golden-Mason, L; Young, L; McLoughlin, P; Nolan, N; McEntee, G; Traynor, O; Geoghegan, T; Hegarty, JE; O'Farrell, C; ; (2004) 'Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation'. Transplantation, 78 (2):250-256. [Details]
Shortt, AJ; Howell, K; O'Brien, C; McLoughlin, P; ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [Details]
Howell, K; Preston, RJ; McLoughlin, P; ; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology-London, 547 (1):133-145. [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) 'Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery'. Eye, 17 (5):628-636. [DOI] [Details]
Howell, K,Preston, RJ,McLoughlin, P; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology-London, 547 :133-145. [DOI] [Details]
Kilbride, E,McLoughlin, P,Gallagher, CG,Harty, HR; (2003) 'Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness?'. Journal of Applied Physiology, 89 :595-602. [DOI] [Details]
Hopkins, N; Cadogan, E; Giles, S; Bannigan, J; McLoughlin, P; ; (2003) 'Type 2 nitric oxide synthase and protein nitration in chronic lung infection'. Journal of Pathology, 199 (1):122-129. [Details]
Kilbride, E; McLoughlin, P; Gallagher, CG; Harty, HR; ; (2003) 'Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness?'. European Journal of Applied Physiology, 89 (6):595-602. [Details]
Loughrey, JPR; Laffey, JG; Moore, BJ; Lynch, F; Boylan, JF; McLoughlin, P; ; (2003) 'Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism'. Critical Care Medicine, 31 (3):910-915. [Details]
Hopkins, N; McLoughlin, P; ; (2002) 'The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?'. Journal of Anatomy, 201 (4):335-348. [Details]
Thin, AG,Linnane, SJ,McKone, EF,Freaney, R,FitzGerald, MX,Gallagher, CG,McLoughlin, P; (2002) 'Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis'. Chest, 121 :1761-1770. [Details]
Kelly G.E., Thin A., Daly L., McLoughlin P.; (2002) 'Erratum. Estimation of the gas exchange threshold in humans: a time series approach'. European Journal of Applied Physiology and Occupational Physiology, 87 :588-588. [Details]
Howell, K; Hopkins, N; McLoughlin, P; ; (2002) 'Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues'. Experimental Physiology, 87 (6):747-756. [Details]
Kennelly, MM; Geary, M; McCaffrey, N; McLoughlin, P; Staines, A; McKenna, P; ; (2002) 'Exercise-related changes in umbilical and uterine artery waveforms as assessed by Doppler ultrasound scans'. American Journal of Obstetrics and Gynecology, 187 (3):661-666. [Details]
Linnane, SJ; Thin, AG; Keatings, VM; Moynihan, JB; McLoughlin, P; FitzGerald, MX; ; (2001) 'Glucocorticoid treatment reduces exhaled nitric oxide in cystic fibrosis patients'. European Respiratory Journal, 17 (6):1267-1270. [Details]
Hopkins, N; Cadogan, E; Giles, S; McLoughlin, P; ; (2001) 'Chronic airway infection leads to angiogenesis in the pulmonary circulation'. Journal of Applied Physiology, 91 (2):919-928. [Details]
Kelly G.E. ,Thin A., Daly L., McLoughlin P.; (2001) 'Estimation of the gas exchange threshold in humans: a time series approach'. European Journal of Applied Physiology and Occupatioal, 85 :586-592. [Details]
O'Connor, S; McLoughlin, P; Gallagher, CG; Harty, HR; ; (2000) 'Ventilatory response to incremental and constant-workload exercise in the presence of a thoracic restriction'. Journal of Applied Physiology, 89 (6):2179-2186. [Details]
O'Connor, S,McLoughlin, P,Gallagher, CG,Harty, HR; (2000) 'Ventilatory response to incremental and constant-workload exercise in the presence of a thoracic restriction'. Journal of Applied Physiology, 89 :2179-2186. [Details]
Ooi, H, Cadogan, E, Sweeney, M, Howell, K, O'Regan, RG, McLoughlin, P, ; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. American Journal of Physiology-Heart and Circulatory Physiology, 278 (2):331-338. [Details]
Lynch, F; Sweeney, M; O'Regan, RG; McLoughlin, P; ; (2000) 'Hypercapnia-induced contraction in isolated pulmonary arteries is endothelium-dependent'. Respiration Physiology, 121 (1):65-74. [Details]
Cadogan, E; Hopkins, N; Giles, S; Bannigan, JG; Moynihan, J; McLoughlin, P; ; (1999) 'Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs'. American Journal of Physiology-Lung Cellular and Molecular Physiology, 277 (3):616-627. [Details]
Thin, AG,Hamzah, Z,FitzGerald, MX,McLoughlin, P,Freaney, R; (1999) 'Lactate determination in exercise testing using an electrochemical analyser: with or without blood lysis?'. Journal of Applied Physiology, 79 :155-159. [Details]
Sweeney, M,O'Regan, RG,McLoughlin, P; (1999) 'Effects of changes in pH and P-CO2 on wall tension in isolated rat intrapulmonary arteries'. Experimental Physiology, 84 :529-539. [Details]
Thin, A.G., Hamzah, Z., FitzGerald, M.X., McLoughlin, P., and Freaney, R.; (1999) 'Lactate determination in exercise testing using an electrochemical analyser: with or without blood lysis'. European Journal of Applied Physiology and Occupatioal, 79 (2):115-159. [Details]
Sweeney, M; Beddy, D; Honner, V; Sinnott, B; O'Regan, RG; McLoughlin, P; ; (1998) 'Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent'. Journal of Applied Physiology, 85 (6):2040-2046. [Details]
Linnane, SJ; Keatings, VM; Costello, CM; Moynihan, JB; O'Connor, CM; Fitzgerald, MX; McLoughlin, P; ; (1998) 'Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis'. American Journal of Respiratory and Critical Care Medicine, 158 (1):207-212. [Details]
O'Donnell DM, Moynihan J, Finlay GA, Keatings VM, O' Connor CM, McLoughlin P, FitzGerald MX. ; (1997) 'Exhaled nitric oxide and BAL nitrite / nitrate in active pulmonary sarcoidosis'. American Journal of Respiratory and Critical Care Medic, 156 :1892-1896. [Details]
Boutcher, PA; Gaffney, PJ; Raut, S; ORegan, RG; McLoughlin, P; ; (1996) 'Effects of early plasmin digests of fibrinogen on isometric tension development in isolated rings of rat pulmonary artery'. Thrombosis Research, 81 (2):231-239. [Details]
MCLOUGHLIN, P, MCCAFFREY, N, MOYNIHAN, JB, ; (1991) 'GENTLE EXERCISE WITH A PREVIOUSLY INACTIVE MUSCLE GROUP HASTENS THE DECLINE OF BLOOD LACTATE CONCENTRATION AFTER STRENUOUS EXERCISE'. European Journal of Applied Physiology and Occupational Physiology, 62 (4):274-278. [Details]
 

Conference Publications

Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P; (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society International Conference [Details]
Cahill E, Costello CM, Howell K, Southwood M, Leonard, M.O., Morrell NW, McLoughlin P; (2010) Lung-Selective Hypoxia-Induced Secretion of the BMP Antagonist Gremlin in Pulmonary Hypertension Keystone Symposium [Details]
Cahill E, Costello CM, Howell K, Harkin S, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2010) Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension American Thoracic Society International Conference 2010 [Details]
Dr. Brian McCullagh, Christine Costello, christine.costello@ucd.ie, Sean Gaine, sgaine@mater.ie, Paul McLoughlin; (2010) CXCL12 as a potential disease marker for pulmonary hypertension European Respiratory Society Annual Congress [Details]
BN McCullagh, CM Costello, K Howell, M Leonard, P McLoughlin, S Gaine; (2010) Lung selective hypoxia response pathways predict changes in cognate ligands in the plasma of pulmonary arterial hypertensive patients American Thoracic Society International Conference 2010 [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Conference Birmingham 2010 [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
Costello, CM, Howell K, Brennan D, Doherty S, Martin, F, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress European Respiratory Society Lung Biology Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells European Respiratory Society Lung Biology Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells Physiological Society Annual Meeting [Details]
Michelle Sands, Katherine Howell, Christine Costello, Paul McLoughlin; (2009) VEGF Family Members can Inhibit Angiogenesis in the Hypoxic Lung Physiological Society Annual General Meeting [Details]
MO Leonard, K Howell, CT Taylor, P McLoughlin. ; (2008) Hypoxic activation of CREB as a mediator of transcriptional alteration within the mouse lung Keystone Conference [Details]
Nichol A, O'Croinin D, Naughton F, Boylan J, McLoughlin P; (2008) Buffered Hypercapnia worsens E coli induced Lung Injury in vivo American Thoracic Society International Conference [Details]
CM Costello, E Cahill, K Howell, P McLoughlin; (2008) Bone morphogenetic protein signalling pathway in chronic hypoxic lung disease Keystone Conference [Details]
K Howell, C Costello, M Sands, P McLoughlin ; (2008) Hypoxia-induced angiogenesis in the lung is nitric oxide dependent American Thoracic Society International Conference [Details]
Adamali HI, Baugh J, Fingerle-Rowson G, McLoughlin P, Donnelly SC; (2008) Enzymatic actvity of macrophage inhibitory factor (MIF) regulates growth of pseudomonas aeruginosa (Pa): implications for therapeutic interventions in cystic fibrosis American Thoracic Society International Conference [Details]
M. Sands, K. Howell, P. McLoughlin; (2008) Pulmonary Hypertension; Stereological Quantification of Intra-Acinar Vessel Length by Lumen Diameter Distribution American Thoracic Society International Conference [Details]
Alistair Nichol, Finola Naughton, Donall O Croinin, John Boylan, Paul McLoughlin; (2007) Hypercapnic acidosis attenuates the neutrophil inflammatory response Australia New Zealand Intensive Care Society Annual Scientific Meeting [Details]
CM Costello, K Howell, F Martin, P McLoughlin; (2007) Expression Profiling Of Cellular Responses To Hypoxia By The Pulmonary Endothelium American Thoracic Society International Conference [Details]
MO. Leonard, K Howell, CT Taylor, Pl McLoughlin.; (2007) Hypoxia induced alterations in the transcriptional profile of the mouse lung European Respiratory Society Lung Science Conference [Details]
MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P McLoughlin, NG McElvaney, MD; (2007) Large airway morphological changes in COPD American Thoracic Society International Conference [Details]
MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P. McLoughlin, NG McElvaney,; (2007) Never smoking patients with Alpha-1 antitrypsin deficiency have morphometrically normal large airway epithelium American Thoracic Society International Conference [Details]
M. Sands, K. Howell, C. Costello, P. McLoughlin; (2007) Angiogenic growth factor expression in the chronically hypoxic lung European Respiratory Society Lung Science Conference [Details]
Nichol A, Naughton F, OCroinin D, McLoughlin P; (2007) Buffered Hypercapnia worsens lung injury in endotoxin induced pneumonia American Thoracic Society International Conference [Details]
Alistair Nichol, Finola Naughton, Donall O Croinin, John Boylan, Paul McLoughlin; (2007) Buffered hypercapnia in acute lung injury Australia New Zealand Intensive Care Society Annual Scientific Meeting [Details]
Katherine Howell, Christine Costello and Paul McLoughlin ; (2007) The Effects of Nitric Oxide on Pulmonary Hypertension and Vessel Size Distribution Physiological Society Annual Meeting, Glasgow [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
Gunning, Y., Hopkins, N. McLoughlin, P.; (2006) Thalidomide treatment in chronic lung infection American Thoracic Society [Details]
Nichol, A., Naughton, F., O`Cronin, D., Boylan, J., Laffey, J. Mc Loughlin, P.; (2006) Buffered hypercapnia worsens lung injury in endotoxin induced lung injury College of Anaesthetists [Details]
Gunning, Y., Hopkins, N. McLoughlin, P.; (2005) Thalidomide treatment in chronic lung infection Irish Thoracic Society [Details]
Nichol, A., O`Cronin, D., Naughton, F. McLoughlin, P.; (2005) Hypercapnia does not attenuate oxidation in endotoxin induced Acute Lung Injury Irish Thoracic Socitey [Details]
Nichol, A., Howell, K. Mc Loughlin, P.; (2005) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Physiological Society Smooth Muscle Symposium [Details]
Keane, PA, O'Brien, C, McLoughlin, P, ; (2005) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE The role of the nitric oxide precursor, L-arginine in angiogenesis involving the globally hypoxic adult retina [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) EYE Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery , pp.628-636 [DOI] [Details]
Varadarajan, R, Young, L, Quinlan, M, McLoughlin, P, Geoghegan, J, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, ; (2002) BRITISH JOURNAL OF SURGERY Nitric oxide expression following reperfusion in human orthotopic liver transplantation , pp.669-669 [Details]
Adamali, HI, Sweeney, M, O'Regan, RG, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Role of plasmalemmal Ca2+-ATPase in acidosis-induced relaxation in isolated rat pulmonary and aortic rings , pp.291-292 [Details]
Kilbride, E, McLoughlin, P, Gallagher, C, Harty, H, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON The incidence of exercise-induced hypoxaemia in a normal healthy female population , pp.49-49 [Details]
Howell, K, Ooi, H, Giles, J, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypoxia increases alveolar capillary endothelial surface area in adult rats , pp.294-295 [Details]
Hopkins, N, Cadogan, E, Giles, S, Bannigan, J, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Immunolocalization of inducible nitric oxide synthase (iNOS) and its effects on pulmonary vasoreactivity following chronic Pseudomonas aeruginosa infection in the rat , pp.110-110 [Details]
Sweeney, M, O'Regan, RG, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Effects of hypercapnic acidosis on vascular smooth muscle tone in isolated rat intrapulmonary arteries , pp.174-174 [Details]
Ooi, H, Cadogan, E, O'Regan, R, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypercapnia inhibits hypoxic pulmonary vasoconstriction by a NO-independent mechanism in chronically hypoxic rats , pp.109-110 [Details]
Beddy, D, McLoughlin, P, ; (1996) JOURNAL OF PHYSIOLOGY-LONDON Effects of hypercapnia on phenylephrine-induced tension and endothelium-dependent relaxation in isolated rings of rat pulmonary artery , pp.54-54 [Details]
BOUTCHER, PA, GAFFNEY, PJ, RAUT, S, MCLOUGHLIN, P, ; (1995) JOURNAL OF PHYSIOLOGY-LONDON EFFECTS OF EARLY AND LATE PLASMIN DIGESTS OF FIBRINOGEN ON ISOMETRIC TENSION DEVELOPMENT IN ISOLATED RINGS OF RAT PULMONARY-ARTERY , pp.164-165 [Details]
   

Editorial

Drummond, GB,Paterson, DJ,McLoughlin, P,McGrath, JC; (2011) Statistics: all together now, one step at a time. Editorial [DOI] [Details]
Drummond, GB,Paterson, DJ,McLoughlin, P,McGrath, JC; (2011) Statistics: all together now, one step at a time. Editorial [DOI] [Details]
Drummond, GB,Paterson, DJ,McLoughlin, P,McGrath, JC; (2011) Statistics: All Together Now, One Step at a Time. Editorial [DOI] [Details]
McLoughlin, P,McMurtry, I; (2007) Counterpoint: Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature. Editorial [Details]
                                                                                   

Research

Research Interests

Our research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. These diseases including chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, adult respiratory distress syndrome and occupational lung diseases and are amongst the most common (and increasing) causes of death and disability worldwide. No major therapeutic advances targeting novel molecular pathways have been made for many years due to our extremely limited knowledge of the underlying mechanisms. 

Lung diseases all cause reduced oxygen in the lung which then activates mechanisms that are pro-inflammatory, pro-thrombotic and promote maladaptive vascular remodelling.  Our current research is focused on understanding the specific mechanisms in the lung through which hypoxia promotes these disease responses.  An understanding of these mechanisms allows us to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.   

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : The role of the bone morphogenetic antagonist gremlin in the pathogenesis of chronic hypoxic lung disease
Start Date / End Date : 01-APR-13 / 01-APR-18
Sponsor : Health Research Board (HRB)
Title : Pulmonary arterial hypertension: role of the bone morphogenetic protein antagonists
Start Date / End Date : 01-OCT-12 / 30-SEP-15
Sponsor : Health Research Board (HRB)
Title : Targeting gremlin in the diagnosis and treatment of fibrotic lung disease
Start Date / End Date : 01-MAY-13 / 30-APR-17
Sponsor : University College Dublin (UCD)
Title : The pathophysiological basis of hypoxic pulmonary hypertension in the mouse: rho kinase dependent vasoconstrictor and structural mechanisms
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : University College Dublin Foundation Ltd.
Title : EP Pulmonary Vascular Biology
Start Date / End Date : 01-OCT-11 / 30-JUN-14
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in Acute Lung Injury SVAF
Start Date / End Date : 01-DEC-11 / 01-DEC-14
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in ALI (ICSI)
Start Date / End Date : 01-OCT-11 / 30-SEP-13
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of MMS
Start Date / End Date : 01-MAR-11 / 29-FEB-16
Sponsor : University College Dublin Foundation Ltd.
Title : Basic mechanisms in human lung disease
Start Date / End Date : 01-AUG-11 / 31-MAR-14
Sponsor : University College Dublin Foundation Ltd.
Title : SVAF CREB responsive genes in acute lung injury
Start Date / End Date : 01-APR-11 / 31-MAR-13
Sponsor : University College Dublin Foundation Ltd.
Title : PVRF: ALI and CREB
Start Date / End Date : 01-NOV-10 / 30-JUN-14
Sponsor : University College Dublin Foundation Ltd.
Title : Intensive-care Medicine
Start Date / End Date : 31-DEC-10 / 30-DEC-13
Sponsor : Health Research Board (HRB)
Title : Signalling pathways that protect against lung damage in the acute respiratory distress syndrome: CREB responsive genes in the lung
Start Date / End Date : 01-JUL-10 / 30-JUN-15