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Ronan O'Connell

School of Medicine & Medical Science

Tel: +353-1-2215124
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Biography

P. Ronan O'Connell is Professor of Surgery and Consultant Surgeon at St Vincent's University Hospital since September 2007. He was previously Senior Lecturer in Surgery at the Royal London Hospital (1989-1990), consultant surgeon at the Mater Misericordiae University Hospital (1990-2007) and Newman Clinical Research Professor at UCD (2002- 2007). In 2009 he was appointed head of the Section of Surgery and Surgical Sciences at University College Dublin. Between 2011 and 2013 he was  Chairman of the South East Dublin Department of Surgery. 

Prof O'Connell graduated from Dublin University, trained in Dublin and Cork and completed specialist training in Colon and Rectal Surgery at the Mayo Clinic, Minnesota, USA. He received the Dublin University Travelling Scholarship in Surgery (1983), a Fogarty Travelling Fellowship from NIH (1984) and a Council of Europe Travelling Scholarship (1989). He holds fellowships of the Royal College of Surgeons in Ireland (1983), the Royal College of Physicians and Surgeons of Glasgow (Honorary) (2001) and the Royal College of Surgeons of Edinburgh (ad hominem) (2014). He was elected to the Council of the Royal College of Surgeons in Ireland in June 2008. Currently he is chairman of the Irish Surgical Post Graduate Training Committee.

Prof O'Connell is a member of the Irish Society of Coloproctology, a fellow of both the Association of Coloproctology of Great Britain and Ireland and the American Society of Colon and Rectal Surgeons. From 2007 to 2010 he was secretary of the European Association of Coloproctology (ESCP). In September 2013 he was elected President of ESCP for 2013-14.  He is a fellow of the Association of Surgeons of Great Britain and Ireland and a member of the Society of Pelvic Surgeons and the International Surgical Group. He is an elected member and Editor in Chief (2010-2013) of the European Surgical Association. In 2010 he was elected to the James¿ IV Society of Surgeons.
  
Prof O'Connell has published widely in the areas of inflammatory bowel disease, pelvic floor physiology and continence. His research has been recognised by numerous awards including the Patey Prize of the Surgical Research Society (1985), the British Journal of Surgery Prize at the Association of Coloproctology Great Britain and Ireland (1995, 1997, 1999 and 2007), the American Society of Colon and Rectal Surgeons Research Prize (2007 and 2010) and the Physiological Society (2009). His research is currently funded by Science Foundation Ireland, the Bowel Disease Research Foundation of ACPGBI, Medtronic Comporation and the EU COST collaboration.
 
Prof O'Connell is Secretary of the British Journal of Surgery (BJS) Society having served as associate editor (1999-2002) and editor (2002-6) of the Journal. He currently is associate editor of Diseases of the Colon and Rectum (since 2001) and is on the editorial board of several journals including the Annals of Surgery. He is joint editor of Bailey and Love's Short Practice of Surgery (25th and 26th editions) and the European Manual in Coloproctology. Prof O'Connell has given numerous invited lectures including the Bacon Lecture to the American Society of Colon and Rectal Surgeons (2003), the Sir Peter Freyer Lecture (2007), the Sir Alan Parks' Lecture at St Mark's Hospital, London (2007), the Hughes Lecture to the Colorectal Surgical Society of Australia and New Zealand (2007) and the Robert Smith lecture to the Association of Surgeons of Great Britain and Ireland (2009), the Golligher Lecture to the Association of Coloproctology Great Britain and Ireland (2014), the Nigel Kinnear Lecture in Trinity College Dublin, (2014), the Hedderman Lecture at University of Limerick (2014) and the Graves' Lecture to the Royal academy of Medicine in Ireland (2014) . In 2014, Prof O'Connell was an invited speaker in UK, United States, Turkey, Spain, Egypt and Israel.

Professional

Honours and Awards

Year: 2010.
Title: ASCRS research prize
Year: 2009.
Title: Best Oral Presentation
Year: 2007.
Title: SIR PETER FREYER RESEARCH PRIZE
Year: 2007.
Title: ASCRS RESEARCH PRIZE
Year: 2007.
Title: BRITISH JOURNAL OF SURGERY PRIZE
Year: 2007.
Title: IRISH SOCIETY OF GASTROENTEROLOGY PRIZE (second)
Year: 2006.
Title: O¿HALLORAN PRIZE

Associations

Association: European Surgical Association, Function/Role: member
Association: American Society of Colon and Rectal Surgeons, Function/Role: elected Fellow
Association: James IV Surgical Society, Function/Role: Director
Association: Society of Pelvic Surgons, Function/Role: elected fellow
Association: International Surgical Group, Function/Role: elected fellow
Association: European Society of Coloproctology, Function/Role: President
     

Conference Contributions

PR O'Connell; (2008) The role of Sentinel Node Biopsy. [Invited Lecture], St Gallen International Colorectal Cancer Meeting, St Galen, Switzerland , 10-DEC-08 - 12-DEC-08.
PR O'Connell; (2008) Colorectal Surgery - Quo vadis. [Invited Oral Presentation], Annual Meeting ACPGBI, Birmingham , 03-JUL-08 - 04-JUL-08.
O'Connell PR; (2008) Complex Diverticular Disease. [Invited Oral Presentation], Americian Socierty of Colon and Rectal Surgeons, Boston , 03-JUN-08 - 04-JUN-08.
PR O'Connell; (2009) An update on rectal Prolapse. [Invited Lecture], Annual Meeting Italian Society of Colon and Rectal Surgeons, Catania, Sicily , 05-OCT-09 - 07-OCT-09.
PR O'Connell; (2009) Changing paradigms in Pelvic Surgery. [Invited Lecture], German Society of Coloproctology, Munich, Germany , 12-MAR-09 - 13-MAR-09.
PR O'Connell; (2009) Tailoring the surgery to the patient. [Invited Lecture], Cancer Conference 2009, St James's Hospital and TCD , 13-MAY-09 - 14-MAY-09.
PR O'Connell; (2009) Robert Smith Lecture. [Invited Lecture], Annual Meeting Association of Surgeons of Great Britain and Ireland, Glasgow , 14-MAY-09 - 15-MAY-09.
PR O'Connell; (2009) Pelvic Floor Disorders ¿ changing paradigms. [Invited Lecture], 14th Conference on Colorectal and Anal Fuction, Tokyo Japan , 31-JUL-09 - 02-AUG-09.
PR O'Connell; (2010) Pelvic Floor Disorders ¿ changing paradigms. [Keynote Address], CHILEAN SCOIETY OF COLOPROCTOLOGY, Pucon, Chile , 22-NOV-10 - 23-NOV-10.
PR O'Connell; (2010) Sacral Nerve Stimulation for Fecal Incontinence. [Keynote Address], COLON AND RECTAL SURGERY: CURRENT PRINCIPLES AND PRACTICE, Minneapolis, Minnesota, USA , 21-OCT-10 - 22-OCT-10.
PR O'Connell; (2010) New paradigms in treatment of Diverticular Disease. [Keynote Address], MINNEAPOLIS SURGICAL SOCIETY, Minneaplois, Minnesota, USA , 20-OCT-10 - 20-JUL-11.
P R O'Connell; (2010) Sacral Nerve Neuromodulation. [Invited Lecture], HÔPITAL SAINTE ANTOINE ¿ DIGESTIVE SURGERY STUDY DAY, Paris , 25-JAN-10 - 25-JAN-10.
PR O'Connell; (2010) Ileoanal anastomosis: the state of play 30 years on. [Invited Lecture], HÔPITAL SAINTE ANTOINE ¿ DIGESTIVE SURGERY STUDY DAY, Paris France , 25-JAN-10 - 25-JAN-10.
PR O'Connell; (2010) Trials that have changed practice in Coloproctology. [Invited Lecture], ASSOCIATION of SURGEONS GREAT BRITAIN AND IRELAND, Liverpool, UK , 21-APR-10 - 22-APR-10.
PR O'Connell; (2010) SNS ¿ the new gold standard for treatment of fecal incontinence¿. [Invited Lecture], KRAKENHAUS WALDFRIEDE COLORECTAL COURSE, Berlin, Germany , 24-JUN-10 - 25-JUN-10.
PR O'Connell; (2010) Neuromodulation in the treatment of fecal incontinence. [Invited Oral Presentation], INTERNATIONAL SURGICAL GROUP, Louisville Kentucky, USA , 15-SEP-10 - 16-JUL-11.
PR O'Connell; (2011) Pathophysiology of ulcerative colitis & pouchitis. [Invited Lecture], ROYAL AUSTRALASIAN COLLEGE OF SURGEONS ANNUAL SCIENTIFIC CONGRESS, Adelaide, SA, Australia , 02-MAY-11 - 05-MAY-11.
PR O'Connell; (2011) Pelvic floor physiology, sacral nerve stimulation and neuromodulation. [Keynote Address], ROYAL AUSTRALASIAN COLLEGE OF SURGEONS ANNUAL SCIENTIFIC CONGRESS, Adelaide, Australia , 02-MAY-11 - 05-MAY-11.
O'Connell, PR.; (2006) Anal Sphincter Repair. [Invited Lecture], ALPINE COLORECTAL MEETING, Verbier, Switzerland , 01-JAN-06.
O'Connell, PR.; (2006) The Pathogenesis of Faecal Incontinence. [Keynote Address], INTERNATIONAL CONTINENCE MEETING, Bari, Italy , 01-SEP-06.
O'Connell, PR.; (2006) The Timing and Technique of Anal Sphincter Repair. [Invited Lecture], INTERNATIONAL CONTINENCE MEETING, Bari, Italy , 01-SEP-06.
O'Connell, PR.; (2006) Publication ' an essential component of surgical training. [Invited Lecture], WATERFORD SURGICAL OCTOBER MEETING, Waterford , 01-OCT-06.
O'Connell, PR.; (2006) The SECCA Procedure. [Invited Lecture], KOREAN SOCIETY OF COLOPROCTOLOGY, Seoul, South Korea , 01-NOV-06.
O'Connell, PR.; (2006) Anal Sphincter Repair. [Invited Lecture], KOREAN SOCIETY OF COLOPROCTOLOGY, Seoul, South Korea , 01-NOV-06.
O'Connell, PR.; (2007) Aetiology, Investigation and Management of Pelvic Floor Disorders. [Invited Lecture], 7TH INTERNATIONAL SYMPOSIUM IN COLORECTAL SURGERY, Lodz, Poland , 01-MAY-07.
O'Connell, PR.; (2007) Publication in an Electronic Era. [Invited Lecture], 7TH INTERNATIONAL SYMPOSIUM IN COLORECTAL SURGERY, Lodz, Poland , 01-MAY-07.
O'Connell, PR.; (2007) Developments in Management of Faecal Incontinence. [Invited Lecture], ANNUAL MEETING CHARTERED PHYSIOTHERAPISTS, Dublin , 01-MAY-07.
O'Connell, PR.; (2007) Fibrogenesis in Crohn's Disease. [Invited Lecture], INTERNATIONAL SURGICAL GROUP, London , 01-AUG-07.
O'Connell, PR.; (2007) Publication in an electronic era. [Invited Lecture], SIR PETER FREYER MEETING, Galway , 01-SEP-07.
O'Connell, PR.; (2007) Obstetric injury to faecal continence mechanisms. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) How to get published. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) Strictures in Crohn's Disease. [Invited Lecture], COLORECTAL SURGICAL SOCIETY OF AUSTRALIA AND NEW ZEALAND and SECTION OF COLON AND RECTAL SURGERY, ROYAL AUSTRALASIAN COLLEGE OF SURGEONS, Adelaide, Australia , 01-OCT-07.
O'Connell, PR.; (2007) Why are research and publication important to the modern surgeon. [Invited Lecture], FRONTIERS IN COLORECTAL SURGERY MEETING, St Mark¿s Hospital, London , 01-NOV-07.

Committees

Committee : Natioanl Colon Cancer Screening Advisory Committee
 

Education

Year 1983 Institution: Royal Coll Surgeons in Ireland
Qualification: FRCSI Subject:
Year 1987 Institution: Trinity College Dublin
Qualification: MD Subject:
Year 1979 Institution: Trinity College Dublin
Qualification: BA Subject:
Year 1979 Institution: Trinity College Dublin
Qualification: BCh Subject:
Year 1979 Institution: Trinity College Dublin
Qualification: BAO Subject:
Year 1979 Institution: Trinity College Dublin
Qualification: MB Subject:
         

Publications

Books

Willaims NS, Bulstrode C, O'Connell PR (2013) Bailey and Love's Short Practice of Surgery. Boca Raton: CRC Press. [Details]
O'Connell PR, Madoff R, Solomon M (2014) Operative Surgery of the Colon, Rectum and Anus. Bacon Rouge: CRC Press. [Details]

Book Chapters

Madoff R, O¿Connell PR, Laurberg S, Matzel K, Mellgren A, Mimura T, Varma M (2012) 'SURGERY FOR FAECAL INCONTINENCE' In: Abrams P, Cardozo L, Khoury S, Wein A (eds). INCONTINENCE. Paris: Health Publications. [Details]
O¿Connell PR, Madoff RD, Counihan T (2014) 'FECAL INCONTINENCE' In: Fazio V, Church J, Delaney C, Kiran R (eds). CURRENT THERAPY IN COLON AND RECTAL SURGERY. New York: ELSEVIER. [Details]
O¿Connell PR, Sheehan G (2014) 'INTRA-ABDOMINAL SEPSIS, PERITONITIS AND PANCREATITIS' In: Cohen J, Powderly WG, Opal SM (eds). INFECTIOUS DISEASES. New York: Mosby Elsevier. [Details]
O¿Connell PR, Gie O (2014) 'SURGICAL MANAGEMENT OF POSTOPERATIVE C. DIFFICILE COLITIS' In: Mizrahi S, Polk HC, Reissman P (eds). REOPERATIVE ABDOMINAL SURGERY. London: JP Medical Press. [Details]
Joyce M, O¿ Connell PR; (2010) 'ANO-RECTAL STENOSIS' In: Clavien JC, Mortensen NMcC, Roche B (eds). ANORECTAL AND COLONIC DISEASES: A PRACTICAL GUIDE TO THEIR MANAGEMENT. Heidleberg: Springer-Verlag. [Details]
O¿Connell PR, Sheehan G; (2010) 'INTRA-ABDOMINAL SEPSIS, PERITONITIS AND PANCREATITIS' In: Cohen J, Opal SM, Powderly WG (eds). INFECTIOUS DISEASES 3rd Edition. New York: Elsevier. [Details]
Docherty NG, O'Connell PR; (2009) 'TNF a neutralization in the medical management of Crohn's Disease' In: Columbus F (eds). Tumour Necrosis Factor Alpha. New York: Nova Science. [Details]
Madoff R, O¿Connell PR, Laurberg S, Matzel K, Mellgren A, Mimura T, Varma M; (2009) 'Surgery for Fecal Incontinence' In: Abrams P, Cardozo L, Khoury S, Wein A (eds). Incontinence. Paris: Health Publications. , pp.1387-1418 [Details]
O'Connell PR; (2008) 'ANAL CANCER' In: Herold A, Matzel K, Lehur PA, O'Connell PR (eds). EUROPEAN MANUAL OF COLOPROCTOLOGY. Frankfurt: Springer. [Details]
Shields C, O'Connell PR; (2007) 'ELECTROCAUTERY' In: Trimbos JB, Trimbos-Kemper TC (eds). BASICS OF SURGERY:tools, techniques, attitude and expertise. Maarseen: Elsevier. [Details]
O'Connell PR; (2004) 'THE VERMIFORM APPENDIX' In: Russell RCG, Bulstrode C, Williams NS (eds). BAILEY and LOVE, SHORT PRACTICE OF SURGERY. London: Arnold. [Details]
Fynes M, O¿Herlihy C, O¿Connell PR; (2002) 'CHILDBIRTH AND PELVIC FLOOR INJURY' In: Pemberton J, Swash M, Henry MM (eds). PELVIC FLOOR: ITS FUNCTION AND DISORDERS. London: Saunders. [Details]
O'Connell PR; (2000) 'THE VERIMFORM APPENDIX' In: Russell RCG, Williams NS (eds). BAILEY and LOVE'S SHORT PRACTICE OF SURGERY. London: Arnold. [Details]
O'Connell PR; (1999) 'A BETTER VIEW IN ANORECTAL SURGERY' In: Walsh C, Jamieson N, Fazio V (eds). TOP TIPS IN GASTROINTESTINAL SURGERY. London: Blackwell. [Details]
O'Connell PR, Gorey TF; (1999) 'World Wide Views in Laparoscopic Colorectal Surgery' In: Wexner SD (eds). PROTOCOLS IN GENERAL SURGERY. New York: Wiley. [Details]
O'Connell PR; (1995) 'Hidradenitis Suppurativa' In: Wexner SD, Varnava AM (eds). Clinical Decision Making in Colorectal Surgery. New York: Igaku-Shoin. [Details]
O'Connell PR; (1991) 'Pseudo-obstruction' In: Kumar D, Waldron D, Williams NS (eds). Clinical Measurements in Coloproctology. London: Springer. [Details]
Womack NR, O'Connell PR; (1991) 'Dynamic Assessment of anorectal function' In: Kumar D, Waldron D, Williams NS (eds). Clinical Measurements in Coloproctology. London: Springer. [Details]
O'Connell PR, Keane FB; (1990) 'Surgery for Ulcerative colitis' In: O'Connell PR, Keane FB; (eds). Ulcerative Colitis. Florida: CRC press. [Details]
O'Connell PR, Kelly KA; (1987) 'The J Pouch' In: Lee E, Nolan DJ (eds). Inflammatory Bowel Disorders. London: Churchill Livingstone. [Details]
Joyce M, O'Connell PR; (2008) 'ANO-RECTAL STENOSIS' In: Clavien JC, Mortensen NMcC (eds). ANORECTAL SURGERY, A PRACTICAL GUIDE TO MANAGEMENT. Frankfurt: Springer. [Details]
O'Connell PR; (2008) 'THE VERMIFORM APPENDIX' In: Williams NS, Bulstrode CJK, O'Connell PR (eds). BAILEY and LOVE, SHORT PRACTICE OF SURGERY, 25th Edition. London: Arnold. [Details]

Edited Books

Williams NS, Bulstrode CJK, O'Connell PR (Ed.). (2008) Bailey and Love's Short Practice of Surgery. London: Hodder Arnold. [Details]
Herold A, Lehur PA, Matzel KE, O'Connell PR (Ed.). (2008) European Manual of Coloproctology. Frankfurt: Sphinger. [Details]

Peer Reviewed Journals

Rowan F, Docherty N.G, Coffey J.C. and O'Connell P.R; (2009) 'Sulphate Reducing Bacteria and Hydrogen Sulphide in the Aetiology of Ulcerative Colitis'. British Journal of Surgery, . [Details]
Peirce, C.,Healy, C. F.,O'Herlihy, C.,O'Connell, P. R.,Jones, J. F.; (2009) 'Reduced somatosensory cortical activation in experimental models of neuropathic fecal incontinence'. Dis Colon Rectum, 52 (88):1417-221417. Available Online [Details]
Coffey, J. C.,Rowan, F.,Burke, J.,Dochery, N. G.,Kirwan, W. O.,O'Connell, P. R.; (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. Am J Gastroenterol, 104 (44):1013-231013. Available Online [Details]
Rowan, F. E.,Docherty, N. G.,Coffey, J. C.,O'Connell, P. R.; (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. Br J Surg, 96 (22):151-8151. Available Online [Details]
Banahan, M,Peirce, C,Buffini, M,O'Herlihy, C,O'Connell, PR,Jones, JFX (2010) 'Atrophy of the sphincters of continence in an experimental model'. Colorectal disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, 12 :153-157. [DOI] [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Diseases of the Colon and Rectum, 53 (11):1530-1536. [DOI] [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Bacterial colonisation of colonic crypts correlates with disease activity in ulcerative colitis'. Annals of Surgery, 252 (5):869-875. [DOI] [Details]
Medani M, Docherty NG, O¿Connell PR, Winter DC (2011) 'THE EMERGING ROLE OF HYDROGEN SULPHIDE IN COLONIC PHYSIOLOGY'. Inflammatory bowel diseases, 17 :1620-1625. [Details]
Martin, S.T. and Heeney, A. and Pierce, C. and O'Connell, P.R. and Hyland, J.M. and Winter, D.C. (2011) 'Use of an electrothermal bipolar sealing device in ligation of major mesenteric vessels during laparoscopic colorectal resection'. Techniques in Coloproctology, 15 (3):285-289. Available Online [DOI] [Details]
Medani, M. and Collins, D. and Docherty, N.G. and Baird, A.W. and O'Connell, P.R. and Winter, D.C. (2011) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflammatory Bowel Diseases, 17 (7):1620-1625. Available Online [DOI] [Details]
Griffin KM, O'Herlihy C, O'Connell PR, Jones JF (2012) 'COMBINED ISCHEMIC AND NEUROPATHIC INSULT TO THE ANAL CANAL IN AN ANIMAL MODEL OF OBSTETRIC-RELATED TRAUMA'. Diseases of the colon and rectum, 55 :32-41. [Details]
Smith, FM,Chang, KH,Sheahan, K,Hyland, J,O'Connell, PR,Winter, DC (2012) 'The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy'. British Journal of Surgery, 99 :993-1001. [DOI] [Details]
Kennelly, RP,Heeney, A,White, A,Fennelly, D,Sheahan, K,Hyland, JMP,O'Connell, PR,Winter, DC (2012) 'A prospective analysis of patient outcome following treatment of T3 rectal cancer with neo-adjuvant chemoradiotherapy and transanal excision'. International Journal of Colorectal Disease, 27 :759-764. [DOI] [Details]
Mohan, HM,McDermott, S,Fenelon, L,Fearon, NM,O'Connell, PR,Oon, SF,Burke, J,Keane, E,Shields, C,Winter, DC (2012) 'Plastic wound retractors as bacteriological barriers in gastrointestinal surgery: a prospective multi-institutional trial'. Journal of Hospital Infection, 81 :109-113. [DOI] [Details]
Kavanagh, DO,Quinlan, DM,Armstrong, JG,Hyland, JMP,O'Connell, PR,Winter, DC (2012) 'Management of synchronous rectal and prostate cancer'. International Journal of Colorectal Disease, 27 :1501-1508. [DOI] [Details]
Larkin JO, O'Connell PR (2012) 'Multivisceral resection for T4 or recurrent colorectal cancer'. Digestive Diseases, 30 (Supp 2):96-101. [DOI] [Details]
Smith, F.M. and Sheahan, K. and Hyland, J. and O'Connell, P.R. and Winter, D.C. (2012) 'Authors' reply: The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy (Br J Surg 2012; 99: 993-1001)'. British Journal of Surgery, 99 (11):1601-1602. Available Online [DOI] [Details]
Kavanagh, D.O. and Quinlan, D.M. and Armstrong, J.G. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2012) 'Management of synchronous rectal and prostate cancer'. International Journal of Colorectal Disease, 27 (11):1501-1508. Available Online [DOI] [Details]
Kennelly, R.P. and Heeney, A. and White, A. and Fennelly, D. and Sheahan, K. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2012) 'A prospective analysis of patient outcome following treatment of T3 rectal cancer with neo-adjuvant chemoradiotherapy and transanal excision'. International Journal of Colorectal Disease, 27 (6):759-764. Available Online [DOI] [Details]
Mohan, H.M. and McDermott, S. and Fenelon, L. and Fearon, N.M. and O'Connell, P.R. and Oon, S.F. and Burke, J. and Keane, E. and Shields, C. and Winter, D.C. (2012) 'Plastic wound retractors as bacteriological barriers in gastrointestinal surgery: A prospective multi-institutional trial'. Journal of Hospital Infection, 81 (2):109-113. Available Online [DOI] [Details]
Smith, F.M. and Chang, K.H. and Sheahan, K. and Hyland, J. and O'Connell, P.R. and Winter, D.C. (2012) 'The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy'. British Journal of Surgery, 99 (7):993-1001. Available Online [DOI] [Details]
Burke JP, Doherty GA, O'Connell PR (2013) 'A survey of current practices used to maintain surgically induced remission following intestinal resection for Crohn's disease'. Colorectal disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
Evers, J,Buffini, M,Craven, S,O'Connell, PR,Jones, JFX (2013) 'Is there a nitrergic modulation of the rat external anal sphincter?'. Experimental Physiology, 98 :397-404. [DOI] [Details]
Kavanagh, DO,Nolan, B,Judge, C,Hyland, JMP,Mulcahy, HE,O'Connell, PR,Winter, DC,Doherty, GA (2013) 'A Comparative Study of Short- and Medium-term Outcomes Comparing Emergent Surgery and Stenting as a Bridge to Surgery in Patients With Acute Malignant Colonic Obstruction'. Diseases Of The Colon & Rectum, 56 :433-440. [DOI] [Details]
Burke JP, Oʼconnell RM, Lennon G, Doherty GA, Keegan D, Oʼdonoghue D, Mulcahy H, Hyland J, Winter DC, Sheahan K, Oʼconnell PR (2013) 'The Influence of CTGF Single-Nucleotide Polymorphisms on Outcomes in Crohn's Disease'. Annals of Surgery, 258 (5):767-774. [Details]
Beyond TME Collaborative (2013) 'Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes'. The British journal of surgery, 100 (8):1009-1014. [Details]
Peirce C, Murphy C, Fitzpatrick M, Cassidy M, Daly L, O'Connell P, O'Herlihy C. (2013) 'Randomised controlled trial comparing early home biofeedback physiotherapy with pelvic floor exercises for the treatment of third-degree tears (EBAPT Trial)'. BJOG: An International Journal of Obstetrics and Gynaecology, 120 (10):1240-1247. [Details]
Hanly AM, Ryan EM, Rogers AC, McNamara DA, Madoff RD, Winter DC; on behalf of the MERRION Study Group. (2013) 'Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION) Therapy'. Annals of Surgery, . [Details]
Burke JP, Doherty GA, O'Connell PR (2013) 'A survey of current practices used to maintain surgically induced remission following intestinal resection for Crohn's disease'. International Journal of Colorectal Disease, 28 (8):1073-1079. [DOI] [Details]
Boyle E, Healy D, Hill AD, O'Connell PR, Kerin M, McHugh S, Coyle P, Kelly J, Walsh SR, Coffey JC. (2013) 'Career choices of today's medical students: where does surgery rank?'. Irish Journal of Medical Science, 182 (3):337-343. [DOI] [Details]
O'Connell PR. (2013) 'Sacral nerve stimulation for constipation'. British Journal of Surgery, 100 (2):181-181. [DOI] [Details]
Kennelly RP, Rogers AC, Winter DC; Abdominoperineal Excision Study Group. (2013) 'Multicentre study of circumferential margin positivity and outcomes following abdominoperineal excision for rectal cancer'. The British journal of surgery, 100 (1):160-166. [DOI] [Details]
Lavelle A, Lennon G, Docherty N, Balfe A, Mulcahy HE, Doherty G, O Donoghue D, Hyland JM, Shanahan F, Sheahan K, Coffey JC, Winter DC, O Connell PR (2013) 'Depth-dependent differences in community structure of the human colonic microbiota in health'. PLoS ONE, 8 (11). [DOI] [Details]
Sahebally SM, Burke JP, Chang KH, Kiernan MG, O'Connell PR, Coffey JC (2013) 'Circulating fibrocytes and Crohn's disease'. The British journal of surgery, 100 (12):1549-1556. [DOI] [Details]
O'Connell PR (2013) 'Rectopexy for incontinence: new solutions or more questions?'. Diseases Of The Colon & Rectum, 56 (12):1330-1331. [DOI] [Details]
Kavanagh, D.O. and Nolan, B. and Judge, C. and Hyland, J.M.P. and Mulcahy, H.E. and O'Connell, P.R. and Winter, D.C. and Doherty, G.A. (2013) 'A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction'. Diseases of the Colon and Rectum, 56 (4):433-440. Available Online [DOI] [Details]
Kavanagh DO, Carter MC, Keegan D, Doherty G, Smith MJ, Hyland JM, Mulcahy H, Sheahan K, O' Connell PR, O' Donoghue DP, Winter DC (2013) 'Management of colorectal cancer in patients with inflammatory bowel disease'. Techniques in coloproctology, . [DOI] [Details]
Lennon G, Balfe A, Bambury N, Lavelle A, Maguire A, Docherty NG, Coffey JC, Winter D, Sheahan K, O`Connell PR. (2014) 'Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis'. Colorectal Disease, 16 (5):1-9. [DOI] [Details]
Soetan BK, O'Connell PR, Jones JF (2014) 'Behavioural studies of faecal continence in the rat'. Irish Journal of Medical Science, . [DOI] [Details]
Lennon G, Balfe A, Earley H, Devane LA, Lavelle A, Winter DC, Coffey JC, O'Connell PR (2014) 'Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis'. Gut Microbes, 5 (3):277-285. [DOI] [Details]
Tevlin, R. and Larkin, J.O. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2014) 'Primary colorectal lymphoma - A single centre experience'. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, . Available Online [DOI] [Details]
Cotter MB, Kelly ME, O'Connell PR, Hyland J, Winter DC, Sheahan K, Gibbons D (2014) 'Anal intraepithelial neoplasia: a single centre 19 year review'. Colorectal Disease, 16 (10):777-782. [DOI] [Details]
Tevlin R, Hanly AM, Rogers AC, Hyland JM, Winter DC, Brannigan AE, O'Connell PR (2014) 'Open versus laparoscopic abdominal rectopexy: an examination of early postoperative outcomes'. Irish Journal of Medical Science, . [DOI] [Details]
Sehgal R, Sheahan K, O'Connell PR, Hanly AM, Martin ST, Winter DC (2014) 'Lynch syndrome: an updated review'. Genes, 5 (3):497-507. [DOI] [Details]
Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JF (2014) 'Effects of stimulation frequency and intensity in sacral neuromodulation on anorectal inputs to the somatosensory cortex in an experimental model'. British Journal of Surgery, 101 (10):1317-1328. [DOI] [Details]
Carrington EV, Evers J, Grossi U, Dinning PG, Scott SM, O'Connell PR, Jones JF, Knowles CH (2014) 'A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation'. Neurogastroenterology and Motility, 26 (9):1222-1237. [DOI] [Details]
O'Toole, A. and Michielsen, A.J. and Nolan, B. and Tosetto, M. and Sheahan, K. and Mulcahy, H.E. and Winter, D.C. and Hyland, J.M. and O'Connell, P.R. and Fennelly, D. and O'Donoghue, D. and O'Sullivan, J. and Doherty, G.A. and Ryan, E.J. (2014) 'Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive'. British Journal of Cancer, 111 (5):927-932. Available Online [DOI] [Details]
Killeen, S. and Martin, S.T. and Hyland, J. and O' Connell, P.R. and Winter, D.C. (2014) 'Clostridium difficile enteritis: A new role for an old foe'. Surgeon, . Available Online [DOI] [Details]
Rogers, A.C. and Gibbons, D. and Hanly, A.M. and Hyland, J.M. and O'Connell, P.R. and Winter, D.C. and Sheahan, K. (2014) 'Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy'. Modern Pathology, 27 (1):156-162. Available Online [DOI] [Details]
Kavanagh, D.O. and Carter, M.C. and Keegan, D. and Doherty, G. and Smith, M.J. and Hyland, J.M.P. and Mulcahy, H. and Sheahan, K. and O'Connell, P.R. and O'Donoghue, D.P. and Winter, D.C. (2014) 'Management of colorectal cancer in patients with inflammatory bowel disease'. Techniques in Coloproctology, 18 (1):23-28. Available Online [DOI] [Details]
Soetan BK, O'Connell PR, Jones JF (2014) 'Behavioural studies of faecal continence in the rat'. Journal Of Medicine, . [DOI] [Details]
O'Connell PR (2014) 'Commentary on Mercer-Jones et Al. [Consensus on Ventral Rectopexy: Report of a Panel of Experts]'. Colorectal Disease, 16 (2):88-89. [DOI] [Details]
Banahan, M.,Peirce, C.,Buffini, M.,O'Herlihy, C.,O'Connell, P. R.,Jones, J. F.; 'Atrophy of the sphincters of continence in an experimental model'. Colorectal Dis, 12 (7 Online7 Online). Available Online [Details]
Buffini, M., O¿Halloran K.D., O¿Herlihy, C., O¿Connell, P.R., Jones, J.F.X (2012) 'COMPARISON OF THE MOTOR DISCHARGE TO THE VOLUNTARY SPHINCTERS OF CONTINENCE IN THE RAT'. Neurogastroenterology and Motility, 24 :e175-e184. [Details]
Kavanagh DO, Quinlan DM, Armstrong JG, Hyland JM, O'Connell PR, Winter DC (2012) 'MANAGEMENT OF SYNCHRONOUS RECTAL AND PROSTATE CANCER'. International Journal of Colorectal Disease, . [Details]
Buffini M, O'Halloran KD, O'Herlihy C, O'Connell PR, Jones JF (2012) 'Comparison of the motor discharge to the voluntary sphincters of continence in the rat'. Neurogastroenterology and Motility, 24 (4):1-84. [DOI] [Details]
Griffin KM, O'Herlihy C, O'Connell PR, Jones JF (2012) 'Combined ischemic and neuropathic insult to the anal canal in an animal model of obstetric-related trauma'. Diseases of the Colon &Amp; Rectum, 55 (1):32-41. [DOI] [Details]
O¿Reilly E, Burke JP, O¿Connell PR (2012) 'LAPAROSCOPIC VERSUS OPEN APPROACH FOR PRIMARY, UNILATERAL, INGUINAL HERNIA: A META-ANALYSIS OF OUTCOMES'. Annals of Surgery, 255 :846-853. [Details]
Kennelly RP, Heeney A, White A, Fennelly D, Sheahan K, Hyland JM, O'Connell PR, Winter DC. (2012) 'A PROSPECTIVE ANALYSIS OF PATIENT OUTCOME FOLLOWING'. International Journal of Colorectal Disease, 27 :759-764. [Details]
Maeda Y, O'Connell PR, Matzel KE, Laurberg S. (2012) 'SACRAL NERVE STIMULATION FOR FECAL INCONTINENCE: AT A CROSSROAD AND FUTURE CHALLENGES'. Diseases of the colon and rectum, 55 :621-624. [Details]
Smith F, Chang KH, Sheahan K, Hyland JH, O¿Connell PR, Winter DC (2012) 'THE SURGICAL SIGNIFICANCE OF RESIDUAL MUCOSAL ABNORMALITIES IN RECTAL CANCER FOLLOWING NEOADJUVANT CHEMORADIOTHERAPY'. British Journal of Surgery, 99 :993-1001. [Details]
Mohan HM, McDermott S, Fenelon L, Fearon NM, O'Connell PR, Oon SF, Burke J, Keane E, Shields C, Winter DC (2012) 'PLASTIC WOUND RETRACTORS AS BACTERIOLOGICAL BARRIERS IN GASTROINTESTINAL SURGERY: A PROSPECTIVE MULTI-INSTITUTIONAL TRIAL'. Journal of Hospital Infection, . [Details]
Peirce, C,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2011) 'Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence'. British Journal of Surgery, 98 :1155-1159. [DOI] [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR; (2010) 'Bacterial Colonization of Colonic Crypt Mucous Gel and Disease Activity in Ulcerative Colitis'. Annals of Surgery, 252 :869-874. [DOI] [Details]
Cunningham, MF,Docherty, NG,Burke, JP,O'Connell, PR; (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. American Journal of Physics, 299 :457-466. [DOI] [Details]
Cunningham, MF,Docherty, NG,Coffey, JC,Burke, JP,O'Connell, PR; (2010) 'Postsurgical Recurrence of Ileal Crohn's Disease: An Update on Risk Factors and Intervention Points to a Central Role for Impaired Host-Microflora Homeostasis'. World journal of surgery, 34 :1615-1628. [DOI] [Details]
Burke, JP,Cunningham, MF,Watson, RWG,Docherty, NG,Coffey, JC,O'Connell, PR; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 :1126-1134. [DOI] [Details]
Medani M, Collins D, Docherty NG, Baird AW, O'Connell PR, Winter DC; (2010) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflammatory bowel diseases, . [DOI] [Details]
Joyce EA, Kavanagh DO, O'Connell PR, Hyland JM; (2011) 'Massive intra-abdominal haemorrhage following stapled haemorrhoidopexy'. Colorectal disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
Burke JP, Cunningham MF, Sweeney C, Docherty NG, O'Connell PR; (2011) 'N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration'. Inflammatory bowel diseases, 17 (8):1665-1673. [DOI] [Details]
Eogan M, O'Brien C, Daly L, Behan M, O'Connell PR, O'Herlihy C; (2011) 'The dual influences of age and obstetric history on fecal continence in parous women'. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 112 (2):93-97. [DOI] [Details]
O'Connell PR; (2011) 'Suboptimal outcome following sacral nerve stimulation for faecal incontinence (Br J Surg 2011; 98: 140-147)'. The British journal of surgery, 98 (1). [DOI] [Details]
Griffin KM, Pickering M, O'Herlihy C, O'Connell PR, Jones JF; (2011) 'Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model'. The British journal of surgery, 98 (8):1160-1169. [DOI] [Details]
Kell MR, O'Connell PR; (2000) 'Femoral nerve neuropraxia after abdominoperineal resection'. Diseases of the colon and rectum, 43 (5). [Details]
Griffin, KM,Blau, CW,Kelly, ME,O'Herlihy, C,O'Connell, PR,Jones, JFX,Kerskens, CM; (2010) 'Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat'. Neuroimage, 51 (4):1395-1404. [DOI] [Details]
O'Connell PR, Heeney A, Mulsow J, ; (2010) 'Vacuum-assisted closure of chronic anorectal fistula'. Colorectal disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
Peirce, C,Alexander, LE,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2010) 'Central Representation of the Inferior Rectal Nerve of the Rat'. Diseases of the colon and rectum, 53 :315-320. [DOI] [Details]
O'Connell PR, Cunningham MF, Docherty NG, Coffey JC, Burke JP, ; (2010) 'Postsurgical Recurrence of Ileal Crohn's Disease: An Update on Risk Factors and Intervention Points to a Central Role for Impaired Host-Microflora Homeostasis'. World journal of surgery, . [DOI] [Details]
Burke, JP,Watson, RWG,Mulsow, JJ,Docherty, NG,Coffey, JC,O'Connell, PR; (2010) 'Endoglin negatively regulates transforming growth factor beta 1-induced profibrotic responses in intestinal fibroblasts'. British Journal of Surgery, 97 :892-901. [DOI] [Details]
O'Connell PR, Ryan JD, Joyce MR, Pierce C, Brannigan A, ; (2009) 'Haematoma in a hydrocele of the canal of Nuck mimicking a Richter's hernia'. Hernia : the journal of hernias and abdominal wall surgery, (NA). [DOI] [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
O'Connell PR, Coffey JC, Rowan F, Burke J, Dochery NG, Kirwan WO, ; (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. American Journal of Gastroenterology, 4 (NA):1013-1023. [DOI] [Details]
Jones JF, Banahan M, Peirce C, Buffini M, O'Herlihy C, O'Connell PR, ; (2010) 'Atrophy of the sphincters of continence in an experimental model'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, . [DOI] [Details]
O'Connell PR, Coffey JC, Docherty NG, ; (2009) 'Hydrogen sulphide: an increasing need for scientific equipoise'. Gastroenterology, 137 (6):2181-211. [DOI] [Details]
Jones JF, Peirce C, Healy CF, O'Herlihy C, O'Connell PR, ; (2009) 'Reduced somatosensory cortical activation in experimental models of neuropathic fecal incontinence'. Diseases of the colon and rectum, 8 (NA):1417-1422. [DOI] [Details]
Peirce C, Buffini M, O'Herlihy C, O'Connell PR, Jones JF.; (2009) 'Central representation of the inferior rectal nerve in the rat'. Diseases of the colon and rectum, . [Details]
O'Riordan JM, Healy CF, McLoughlin D, Cassidy M, Brannigan AE, O'Connell PR.; (2009) 'ANTIPLATELET AGENTS IN THE PERIOPERATIVE PERIOD'. Archives of Surgery, 144 (1):69-76. [Details]
O'Connell PR, Rowan FE, Docherty NG, Coffey JC, ; (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. British Journal of Surgery, 2 (NA):151-158. [DOI] [Details]
Healy, CF,McMorrow, C,O'Herlihy, C,O'Connell, PR,Jones, JFX; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Gastroenterology, 20 :719-724. [DOI] [Details]
Peirce C, Healy CF, O'Herlihy C, O'Connell, PR & Jones JFX; (2008) 'Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model'. Obstetrics and Gynecology, 112 (4):943-944. [Details]
Mahony, R,Behan, M,O'Connell, PR,O'Herlihy, C; (2008) 'Effect of second vaginal delivery on anal function in patients at risk of occult anal sphincter injury after first forceps delivery'. Diseases of the colon and rectum, 51 (NA):1361-1366. [DOI] [Details]
Fakhro A, O¿Riordan JM, Lawler LP, O¿Connell PR; (2008) 'CECAL VULVULUS AS A COMPLICATION OF GASTRIC BANDING'. Obesity Surgery, . [DOI] [Details]
Jones JF, Healy CF, McMorrow C, O'Herlihy C, O'Connell PR, ; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Neurogastroenterology and Motility, 6 (NA):719-724. [DOI] [Details]
Jones JF, Healy CF, O'Herlihy C, O'Brien C, O'Connell PR, ; (2008) 'Experimental models of neuropathic fecal incontinence: an animal model of childbirth injury to the pudendal nerve and external anal sphincter'. Diseases of the Colon &Amp; Rectum, 11 (NA):1619-161. [DOI] [Details]
Jones JF, Peirce C, Healy CF, O'Herlihy C, O'Connell PR, ; (2008) 'Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model'. Obstetrics & Gynecology, 4 (NA):943-91. [DOI] [Details]
O'Connell PR, ; (2008) 'Stapled haemorrhoidopexy for the treatment of haemorrhoids: a systematic review Burch J, Epstein D, Baba-Akbari Sari A et al, Colorectal Disease doi: 10.1111/j.1463-1318.2008.01638.x'. Colorectal disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, (NA). [DOI] [Details]
Mahony R, Behan M, Daly L, Kirwan C, O'Herlihy C, O'Connell PR.; (2007) 'Internal anal sphincter defect influences continence outcome following obstetric anal sphincter injury'. American Journal of Obstetrics and Gynecology, 196 (3). [Details]
O'Connell PR, Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, ; (2007) 'Fibrogenesis in Crohn's disease'. American Journal of Gastroenterology, 2 (NA):439-448. [DOI] [Details]
Eogan M, Daly L, Behan M, O'Connell PR, O'Herlihy C.; (2007) 'Randomised clinical trial of a laxative alone versus a laxative and a bulking agent after primary repair of obstetric anal sphincter injury'. British Journal of Obstetrics and Gynaecology, 114 (6):736-740. [Details]
McGuire, B. B.,Brannigan, A. E.,O'Connell, P. R.; (2007) 'Ileal pouch-anal anastomosis'. British Journal of Surgery, 94 (7):812-23. Available Online [Details]
Beddy, D.,Mulsow, J.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R.; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 93 (10):1290-6. Available Online [Details]
Eogan, M., Daly, O'Connell, PR L., O'Herlihy, C.; (2006) 'Does the angle of episiotomy affect the incidence of anal sphincter injury?'. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 113 (2):190-194. [Details]
Burke JP, Cunningham MF, Watson RWG, , Docherty NG, Coffey JC, O¿Connell PR ; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 (7):1126-1134. [Details]
Mulsow, J. J.,Watson, R. W.,Fitzpatrick, J. M.,O'Connell, P. R.; (2005) 'Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling'. Annals of Surgery, 242 (6):880-7, discus. Available Online [Details]
Cunningham MF, Docherty NG, Burke JP, O'Connell PR; (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. American Journal of Physiology Gastrointestinal Physiology, 299 (2):457-466. [Details]
McGuire, B.,Brannigan, A. E.,O'Connell, P. R.; (2005) 'Hyaluronidase assisted reduction of intestinal intussusception; a novel application'. Irish Medical Journal, 98 (5):146-7. Available Online [Details]
Rowan F, Docherty NG, Murphy M, Murphy B, Calvin Coffey J, O'Connell PR.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Diseases of the Colon &Amp; Rectum, 53 (11):1530-1536. [Details]
Healy, D. G.,Veerasingam, D.,O'Connell, P. R.,Hurley, J.; (2004) 'Acute acalculous cholecystitis following coronary artery bypass surgery'. Ir J Med Sci, 173 (3):160-1. Available Online [Details]
Buffini M, O'Halloran KD, O'Herlihy C, O'Connell R, Jones JF; (2010) 'Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat'. Journal of Anatomy, 217 (3):187-195. [Details]
Mahony, RT; Malone, PA; Nalty, J; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2004) 'Randomized clinical trial of intra-anal electromyographic biofeedback physiotherapy with intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter in the early treatment of postpartum fecal incontinence'. American Journal of Obstetrics and Gynecology, 191 (3):885-890. [Details]
Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O¿Connell PR; (2010) 'CULTURE INDEPENDENT QUANTIFICATION OF TOTAL BACTERIAL COLONIZATION OF COLONIC CRYPTS IN PATIENTS WITH ULCERATIVE COLITIS AND CONTROLS'. Annals of Surgery, . [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
McGuinness, J.,Winter, D. C.,O'Connell, P. R.; (2004) 'Balloon tamponade to control haemorrhage following transanal rectal surgery'. Int J Colorectal Dis, 19 (4):395-6. Available Online [Details]
Mahony, R.,Behan, M.,O'Herlihy, C.,O'Connell, P. R.; (2004) 'Randomized, clinical trial of bowel confinement vs. laxative use after primary repair of a third-degree obstetric anal sphincter tear'. Dis Colon Rectum, 47 (1):12-7. Available Online [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Beddy, DJ, Watson, WR, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease'. Journal of the American College of Surgeons, 199 (2):234-242. [Details]
Mahony, R, Malone, P, Nalty, J, Cassidy, M, O'Connell, PR, O'Herlihy, C, ; (2003) 'Prospective randomized comparison of intra-anal electromyographic biofeedback and intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter'. American Journal of Obstetrics and Gynecology, 189 (6):71-71. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Fitzpatrick, M,Behan, M,O'Connell, PR,O'Herlihy, C; (2003) 'Randomised clinical trial to assess anal sphincter function following forceps or vacuum assisted vaginal delivery'. British Journal of Obstetrics and Gynaecology, 110 :424-429. [DOI] [Details]
Harkin, R,Fitzpatrick, M,O'Connell, PR,O'Herlihy, C; (2003) 'Anal sphincter disruption at vaginal delivery: is recurrence predictable?'. European Journal of Obstetrics Gynecology and Reproductive Biology, 109 :149-152. [DOI] [Details]
McNamara, D. A.,Fitzpatrick, J. M.,O'Connell, P. R.; (2003) 'Urinary tract involvement by colorectal cancer'. Dis Colon Rectum, 46 (9):1266-76. Available Online [Details]
McGuinness, J. G.,Winter, D. C.,O'Connell, P. R.; (2003) 'Vacuum-assisted closure of a complex pilonidal sinus'. Diseases of the colon and rectum, 46 (2):274-6. Available Online [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Eogan, M; O'Brien, C; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Long-term effects of childbirth on fecal continence and pudendal nerve function'. American Journal of Obstetrics and Gynecology, 189 (6):72-72. [Details]
Mahony, R; Malone, P; Nalty, J; Cassidy, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Prospective randomized comparison of intra-anal electromyographic biofeedback and intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter'. American Journal of Obstetrics and Gynecology, 189 (6):71-71. [Details]
Mahony, R; Fitzpatrick, N; Kirwan, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Review of four hundred women presenting after a third-degree tear'. American Journal of Obstetrics and Gynecology, 189 (6):201-201. [Details]
Fitzpatrick, M.,O'Brien, C.,O'Connell P, R.,O'Herlihy, C.; (2003) 'Patterns of abnormal pudendal nerve function that are associated with postpartum fecal incontinence'. Am J Obstet Gynecol, 189 (3):730-5. Available Online [Details]
Fitzpatrick, M,Cassidy, M,O'Connell, PR,O'Herlihy, C; (2002) 'Experience with an obstetric perineal clinic'. European Journal of Obstetrics Gynecology and Reproductive Biology, 100 :199-203. [Details]
Brannigan, AE, Watson, WG, Beddy, D, Hurley, H, Fitzpatrick, JM, O'Connell, PR, ; (2002) 'Increased adhesion molecule expression in serosal fibroblasts isolated from patients with inflammatory bowel disease is secondary to inflammation'. Annals of Surgery, 235 (4):507-511. [Details]
Fitzpatrick, M; Harkin, R; McQuillan, K; O'Brien, C; O'Connell, PR; O'Herlihy, C; ; (2002) 'A randomised clinical trial comparing the effects of delayed versus immediate pushing with epidural analgesia on mode of delivery and faecal continence'. Bjog-An International Journal of Obstetrics and Gynaecology, 109 (12):1359-1365. [Details]
Tan, M.,O'Hanlon, D. M.,Cassidy, M.,O'Connell, P. R.; (2001) 'Advantages of a posterior fourchette incision in anal sphincter repair'. Diseases of the colon and rectum, 44 (11):1624-9. Available Online [Details]
Fitzpatrick, M, Behan, M, O'Connell, PR, O'Herlihy, C, ; (2000) 'A randomized clinical trial comparing primary overlap with approximation repair of third-degree obstetric tears'. American Journal of Obstetrics and Gynecology, 183 (5):1220-1224. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
Fitzpatrick, M; Fynes, M; Cassidy, M; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2000) 'Prospective study of the influence of parity and operative technique on the outcome of primary anal sphincter repair following obstetrical injury'. European Journal of Obstetrics Gynecology and Reproductive Biology, 89 (2):159-163. [Details]
Fynes, MM; Behan, M; O'Herlihy, C; O'Connell, PR; ; (2000) 'Anal vector volume analysis complements endoanal ultrasonographic assessment of postpartum anal sphincter injury'. British Journal of Surgery, 87 (9):1209-1214. [Details]
Regan, M. C.,Flavin, B. M.,Fitzpatrick, J. M.,O'Connell, P. R.; (2000) 'Stricture formation in Crohn's disease: the role of intestinal fibroblasts'. Annals of Surgery, 231 (1):46-50. Available Online [Details]
O'Connell, P. R.; (2000) 'What should surgeons write?'. British Journal of Surgery, 87 (2):132-4. Available Online [Details]
Fitzpatrick, M.,Fynes, M.,Cassidy, M.,Behan, M.,O'Connell, P. R.,O'Herlihy, C.; (2000) 'Prospective study of the influence of parity and operative technique on the outcome of primary anal sphincter repair following obstetrical injury'. Eur J Obstet Gynecol Reprod Biol, 89 (2):159-63. Available Online [Details]
Fynes, MM, Marshall, K, Cassidy, M, Behan, M, Walsh, D, O'Connell, PR, O'Herlihy, C, ; (1999) 'A prospective, randomized study comparing the effect of augmented biofeedback with sensory biofeedback alone on fecal incontinence after obstetric trauma'. Diseases of the colon and rectum, 42 (6):753-758. [Details]
Prendergast, P. J.,Beverland, D. E.,Blayney, A. W.,Dunne, N. J.,Gorey, T. F.,Grace, P. A.,McCormack, B. A.,McGloughlin, T.,O'Connell, P. R.,Orr, J. F.; (1999) 'Modelling medical devices: the application of bioengineering in surgery'. Ir J Med Sci, 168 (1):3-7. Available Online [Details]
Delaney, C. P.,O'Connell, P. R.; (1999) 'Towards consensus on the fate of the normal appendix at laparoscopy for suspected appendicitis'. Ir J Med Sci, 168 (2):109-10. Available Online [Details]
Fynes, M.,Donnelly, V.,Behan, M.,O'Connell, P. R.,O'Herlihy, C.; (1999) 'Effect of second vaginal delivery on anorectal physiology and faecal continence: a prospective study'. Lancet, 354 (9183):983-6. Available Online [Details]
Donnelly, V, Fynes, M, Campbell, D, Johnson, H, O'Connell, PR, O'Herlihy, C, ; (1998) 'Obstetric events leading to anal sphincter damage'. Obstetrics & Gynecology, 92 (6):955-961. [Details]
Duffy, MM, Regan, MC, Ravichandran, P, O'Keane, C, Harrington, MG, Fitzpatrick, JM, O'Connell, PR, ; (1998) 'Mucosal metabolism in ulcerative colitis and Crohn's disease'. Diseases of the colon and rectum, 41 (11):1399-1405. [Details]
Donnelly, VS; O'Herlihy, C; Campbell, DM; O'Connell, PR; ; (1998) 'Postpartum fecal incontinence is more common in women with irritable bowel syndrome'. Diseases of the colon and rectum, 41 (5):586-589. [Details]
Teh, S. H.,O'Riordain, D. S.,O'Connell, P. R.; (1998) 'Colonic pseudo-obstruction following acute pancreatitis'. Ir J Med Sci, 167 (1):41-2. Available Online [Details]
Fynes, M.,Donnelly, V. S.,O'Connell, P. R.,O'Herlihy, C.; (1998) 'Cesarean delivery and anal sphincter injury'. Obstet Gynecol, 92 (4 Pt 1):496-500. Available Online [Details]
Duncan, C. O.,Earley, M. J.,O'Connell, P. R.; (1998) 'Enterocutaneous fistula: a reconstructive dilemma'. Ir J Med Sci, 167 (1):9-10. Available Online [Details]
Duffy, M. M.,Regan, M. C.,Harrington, M. G.,Fitzpatrick, J. M.,O'Connell, P. R.; (1998) 'Metabolic substrate utilization differs in ileal faecal and urinary reservoirs'. British Journal of Surgery, 85 (6):804-8. Available Online [Details]
Donnelly, V. S.,O'Herlihy, C.,Campbell, D. M.,O'Connell, P. R.; (1998) 'Postpartum fecal incontinence is more common in women with irritable bowel syndrome'. Dis Colon Rectum, 41 (5):586-9. Available Online [Details]
Corby, H.,Donnelly, V. S.,O'Herlihy, C.,O'Connell, P. R.; (1997) 'Anal canal pressures are low in women with postpartum anal fissure'. Br J Surg, 84 (1):86-8. Available Online [Details]
Donnelly, V.,O'Connell, P. R.,O'Herlihy, C.; (1997) 'The influence of oestrogen replacement on faecal incontinence in postmenopausal women'. Br J Obstet Gynaecol, 104 (3):311-5. Available Online [Details]
Gul, Y. A.,Waldron, D. J.,O'Connell, P. R.; (1997) 'Stercoral perforation associated with parathyroid adenoma'. Ir Med J, 90 (1). Available Online [Details]
O'Riordain, D. S.,O'Connell, P. R.; (1997) 'Completion proctectomy in ulcerative colitis'. Br J Surg, 84 (4):436-7. Available Online [Details]
Campbell, D. M.,Behan, M.,Donnelly, V. S.,O'Herlihy, C.,O'Connell, P. R.; (1996) 'Endosonographic assessment of postpartum anal sphincter injury using a 120 degree sector scanner'. Clin Radiol, 51 (8):559-61. Available Online [Details]
O'Byrne, J. M.,O'Connell, P. R.,Nolan, N.,Keane, F. B.,Tanner, W. A.; (1996) 'Morphology, mucin histochemistry and crypt cell kinetics of ileal mucosa in an experimental model'. Int J Colorectal Dis, 11 (1):52-5. Available Online [Details]
Durkan, G. C.,Cross, K. S.,O'Connell, P. R.; (1996) 'Case report: vitello-intestinal remnant complicating laparoscopic cholecystectomy'. Ir J Med Sci, 165 (3). Available Online [Details]
Kent, P.,Bannon, C. A.,Beausang, O.,O'Connell, P. R.,Corrigan, T. P.,Gorey, T. F.; (1995) 'The introduction of laparoscopic cholecystectomy--audit of transition period with late follow-up'. Ir J Med Sci, 164 (1):1-3. Available Online [Details]
Attwood, S. E.,Kelly, I.,O'Connell, P. R.,Corrigan, T.; (1993) 'Laparoscopic mobilization and exteriorization for minimally invasive small bowel resection'. Br J Surg, 80 (2). Available Online [Details]
Hickey, K.,McKenna, P.,O'Connell, P. R.,Gillan, J. E.; (1993) 'Actinomycosis presenting as appendicitis in pregnancy'. Br J Obstet Gynaecol, 100 (6):595-6. Available Online [Details]
Horgan, P. G.,O'Connell, P. R.; (1993) 'Subumbilical hernia following laparoscopic cholecystectomy'. Br J Surg, 80 (12). Available Online [Details]
Chapman, M. A.,Grahn, M. F.,Giamundo, P.,O'Connell, P. R.,Onwu, D.,Hutton, M.,Maudsley, J.,Norton, B.,Rogers, J.,Williams, N. S.; (1993) 'New technique to measure mucosal metabolism and its use to map substrate utilization in the healthy human large bowel'. Br J Surg, 80 (4):445-9. Available Online [Details]
GOREY, TF,OCONNELL, PR,WALDRON, D,CRONIN, K,KERIN, M,FITZPATRICK, JM; (1993) 'LAPAROSCOPICALLY ASSISTED REVERSAL OF HARTMANNS PROCEDURE'. British Journal of Surgery, 80 :109-109. [Details]
McAnena, O. J.,Austin, O.,O'Connell, P. R.,Hederman, W. P.,Gorey, T. F.,Fitzpatrick, J.; (1992) 'Laparoscopic versus open appendicectomy: a prospective evaluation'. Br J Surg, 79 (8):818-20. Available Online [Details]
Giamundo, P.,Grahn, M. F.,O'Connell, P. R.,Williams, N. S.; (1991) 'Mucosal metabolic activity in endoscopic intestinal biopsy specimens'. Dig Dis Sci, 36 (4). Available Online [Details]
O'Connell, P. R.,Williams, N. S.; (1991) 'Mucosectomy in restorative proctocolectomy'. Br J Surg, 78 (2):129-30. Available Online [Details]
O'Donnell, A. F.,O'Connell, P. R.,Royston, D.,Johnston, D. H.,Barnard, R.,Bouchier-Hayes, D.; (1991) 'Suture technique affects perianastomotic colonic crypt cell production and tumour formation'. Br J Surg, 78 (6):671-4. Available Online [Details]
O'Riordain, D. S.,O'Connell, P. R.,Kirwan, W. O.; (1991) 'Hereditary sacral agenesis with presacral mass and anorectal stenosis: the Currarino triad'. Br J Surg, 78 (5):536-8. Available Online [Details]
O'Connell, P. R.,Lynch, G.; (1990) 'Reversed intestinal rotation associated with anomalous mesenteric venous drainage. Report of a case'. Dis Colon Rectum, 33 (10):883-5. Available Online [Details]
Young, V.,O'Connell, P. R.,Keane, F. B.; (1990) 'The role of adjuvant therapy in the management of node negative breast cancer'. Ir Med J, 83 (1):34-5. Available Online [Details]
Horgan, P. G.,O'Connell, P. R.,Shinkwin, C. A.,Kirwan, W. O.; (1989) 'Effect of anterior resection on anal sphincter function'. Br J Surg, 76 (8):783-6. Available Online [Details]
Crowley, K. J.,Cunningham, A. J.,Conroy, B.,O'Connell, P. R.,Collins, P. G.; (1988) 'Phaeochromocytoma--a presentation mimicking malignant hyperthermia'. Anaesthesia, 43 (12):1031-2. Available Online [Details]
O'Connell, P. R.,Kirwan, W. O.,Brady, M. P.,O'Donnell, J. A.; (1988) 'Surgical audit: the value of a morbidity and mortality conference'. Ir J Med Sci, 157 (4):100-3. Available Online [Details]
O'Connell, P. R.,Stryker, S. J.,Metcalf, A. M.,Pemberton, J. H.,Kelly, K. A.; (1988) 'Anal canal pressure and motility after ileoanal anastomosis'. Surg Gynecol Obstet, 166 (1):47-54. Available Online [Details]
O'Connell, P. R.,Kelly, K. A.; (1987) 'Enteric transit and absorption after canine ileostomy. Effect of pacing'. Arch Surg, 122 (9):1011-7. Available Online [Details]
O'Connell, P. R.,Pemberton, J. H.,Brown, M. L.,Kelly, K. A.; (1987) 'Determinants of stool frequency after ileal pouch-anal anastomosis'. Am J Surg, 153 (2):157-64. Available Online [Details]
O'Connell, P. R.,Pemberton, J. H.,Kelly, K. A.; (1987) 'Motor function of the ileal J pouch and its relation to clinical outcome after ileal pouch-anal anastomosis'. World J Surg, 11 (6):735-41. Available Online [Details]
O'Connell, P. R.,Kelly, K. A.,Brown, M. L.; (1986) 'Scintigraphic assessment of neorectal motor function'. J Nucl Med, 27 (4):460-4. Available Online [Details]
O'Connell, P. R.,Rankin, D. R.,Weiland, L. H.,Kelly, K. A.; (1986) 'Enteric bacteriology, absorption, morphology and emptying after ileal pouch-anal anastomosis'. Br J Surg, 73 (11):909-14. Available Online [Details]
Healy, C. F.,McMorrow, C.,O'Herlihy, C.,O'Connell, P. R.,Jones, J. F.; (2008) 'External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model'. Neurogastroenterol Motil, 20 (6):719-24. Available Online [Details]
O'Riordan, J. M.,Healy, C. F.,McLoughlin, D.,Cassidy, M.,Brannigan, A. E.,O'Connell, P. R.; (2008) 'Sacral nerve stimulation for faecal incontinence'. Irish Journal of Medical Science, 177 (2):117-9. Available Online [Details]
Brennan DJ , Moynagh M , Brannigan AE , Gleeson F , Rowland M , O'Connell PR; (2007) 'Routine mobilization of the splenic flexure is not necessary during anterior resection for rectal cancer'. Diseases of the Colon and Rectum, 50 :302-307. [Details]
Mahony R, O'Brien C, Kinsley B, Firth R, Coffey M, O'Connell R, O'Herlihy C; (2007) 'Antepartum pudendal neuropathy and the effect of vaginal delivery in women with type 1 diabetes mellitus'. International Journal of Diabetes and Metabolism, . [Details]
Eogan, M; O'Brien, C; Daly, L; Byrne, P; O'Connell, PR; O'Herlihy, C; ; (2005) 'Monitoring pudendal nerve conduction during labor and early puerperium'. American Journal of Obstetrics and Gynecology, 193 (6):41-41. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
Harkin, R; Fitzpatrick, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Anal sphincter disruption at vaginal delivery: is recurrence predictable?'. European Journal of Obstetrics Gynecology and Reproductive Biology, 109 (2):149-152. [Details]
McNamara, DA; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'Urinary tract involvement by colorectal cancer'. Diseases of the colon and rectum, 46 (9):1266-1276. [Details]
Mulsow, J; Winter, DC; O'Keane, JC; O'Connell, PR; ; (2003) 'Sentinel lymph node mapping in colorectal cancer'. British Journal of Surgery, 90 (6):659-667. [Details]
Fitzpatrick, M; Behan, M; O'Connell, PR; O'Herlihy, C; ; (2003) 'Randomised clinical trial to assess anal sphincter function following forceps or vacuum assisted vaginal delivery'. Bjog-An International Journal of Obstetrics and Gynaecology, 110 (4):424-429. [Details]
Fitzpatrick, M; O'Brien, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Patterns of abnormal pudendal nerve function that are associated with postpartum fecal incontinence'. American Journal of Obstetrics and Gynecology, 189 (3):730-735. [Details]
Mahony, R; Fitzpatrick, N; Kirwan, C; O'Connell, PR; O'Herlihy, C; ; (2003) 'Review of four hundred women presenting after a third-degree tear'. American Journal of Obstetrics and Gynecology, 189 (6):201-201. [Details]
McGuinness, JG; Winter, DC; O'Connell, PR; ; (2003) 'Vacuum-assisted closure of a complex pilonidal sinus'. Diseases of the colon and rectum, 46 (2):274-276. [Details]
Medani M, Docherty NG, O¿Connell PR, Winter DC ; (2010) 'THE EMERGING ROLE OF HYDROGEN SULPHIDE IN COLONIC PHYSIOLOGY'. Inflammatory bowel diseases, . [Details]
Burke JP, Cunningham MF, Docherty NG, O¿Connell PR ; (2010) 'N-CADHERIN IS OVER-EXPRESSED IN CROHN'S STRICTURE FIBROBLASTS AND PROMOTES INTESTINAL FIBROBLAST MIGRATION'. Inflammatory bowel diseases, . [Details]
Donohoe CL, Brannigan AE, O'Connell PR.; (2010) 'PALLIATIVE ENDOSCOPIC TRANS-ANAL RESECTION OF ADVANCED RECTOSIGMOID CARCINOMA'. Irish Journal of Medical Science, . [Details]
Shields CJ, Tiret E, Winter DC, Baum RP, Mortensen N, Fazio VW, Stocchi L, Sheahan K, O¿Keane C, Brannigan A, O¿Connell PR, Parc Y, Mourra N,Garcia-Olmo D, Soreide K, Prasad V, Kaemmerer D, Flemming M, Sagar P.; (2010) 'CARCINOID TUMOURS OF THE RECTUM ¿ A MULTI-INSTITUTIONAL INTERANTIONAL COLLABORATION'. Annals of Surgery, 252 :750-755. [Details]
O'Connell R, Skrabanek P, Cannon D, Powell D; (1976) 'High-sensitivity radioimmunoassay for substance P'. IRISH J MED SCI, 145 :392-398. [Details]
Kanazawa I, Bird E, O'Connell R, Powell D.; (1977) 'Evidence for a decrease in substance P content of substantia nigra in Huntington's chorea'. Brain Research, 120 :387-392. [Details]
Rowan F, Coffey JC, Oʼconnell PR, Docherty NG, Murphy M, Murphy TB.; (2011) 'Ileal Pouch Microbial Diversity'. Annals of Surgery, . [Details]
O'Connor MK, O'Connell R, Keane FB, Byrne PJ, Hennessy TP; (1983) 'The relationship between technetium 99m pertechnetate gastric scanning and gastric contents'. British Journal of Radiology, 56 :817-822. [Details]
Hennessy TP, O'Connell R; (1984) 'Surgical treatment of squamous cell carcinoma of the oesophagus'. British Journal of Surgery, 71 :750-751. [Details]
Hennessy TP, O'Connell R; (1986) 'Carcinoma of the hypopharynx, esophagus and cardia'. Journal of the American College of Surgeons, 162 :243-247. [Details]
Martin ST, Heeney A, Pierce C, O'Connell PR, Hyland JM, Winter DC.; (2011) 'Use of an electrothermal bipolar sealing device in ligation of major mesenteric vessels during laparoscopic colorectal resection'. Techniques in coloproctology, 15 (3):285-289. [Details]
Donohoe CL, Brannigan AE, O'Connell PR; (2011) 'PALLIATIVE ENDOSCOPIC TRANS-ANAL RESECTION OF ADVANCED RECTOSIGMOID CARCINOMA'. The Irish Journal of Medical Science, 180 :541-544. [DOI] [Details]

Other Journals

Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis' Diseases of the Colon and Rectum 53 (4) :541-541. [Details]
Rowan F., Docherty N.G., Murphy M., Murphy T.B., Coffey J.C., O'Connell P.R. (2011) 'Ileal pouch microbial diversity' Annals of Surgery 254 (4) :669-670. [DOI] [Details]
Peirce C, Alexander LE, Buffini, M. O'Herlihy C, O'Connell PR, Jones JF.; (2009) 'Investigation of the nerve supply to the external anal sphincter (EAS) in the female rat' British Journal of Surgery 96(S5) :37 . [Details]

Conference Publications

Duffy, MM,Regan, MC,Ravichandran, P,O'Keane, C,Harrington, MG,Fitzpatrick, JM,O'Connell, PR (1998) DISEASES OF THE COLON & RECTUM Mucosal metabolism in ulcerative colitis and Crohn's disease , pp.1399-1405 [Details]
Duffy, MM,Regan, MC,Harrington, MG,Fitzpatrick, JM,O'Connell, PR (1998) BRITISH JOURNAL OF SURGERY Metabolic substrate utilization differs in ileal faecal and urinary reservoirs , pp.804-808 [Details]
Donnelly, VS,O'Herlihy, C,Campbell, DM,O'Connell, PR (1998) DISEASES OF THE COLON & RECTUM Postpartum fecal incontinence is more common in women with irritable bowel syndrome , pp.586-589 [Details]
Fynes, MM,Marshall, K,Cassidy, M,Behan, M,Walsh, D,O'Connell, PR,O'Herlihy, C (1999) DISEASES OF THE COLON & RECTUM A prospective, randomized study comparing the effect of augmented biofeedback with sensory biofeedback alone on fecal incontinence after obstetric trauma , pp.753-758 [Details]
Fitzpatrick, M,Behan, M,O'Connell, PR,O'Herlihy, C (2000) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY A randomized clinical trial comparing primary overlap with approximation repair of third-degree obstetric tears , pp.1220-1224 [DOI] [Details]
Fitzpatrick, M,O'Brien, C,O'Connell, PR,O'Herlihy, C (2003) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Patterns of abnormal pudendal nerve function that are associated with postpartum fecal incontinence , pp.730-735 [DOI] [Details]
Beddy, DJ,Watson, WR,Fitzpatrick, JM,O'Connell, PR (2004) JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease , pp.234-242 [DOI] [Details]
Mahony, R,Behan, M,O'Herlihy, C,O'Connell, PR (2004) DISEASES OF THE COLON & RECTUM Randomized, clinical trial of bowel confinement vs. laxative use after primary repair of a third-degree obstetric anal sphincter tear , pp.12-17 [DOI] [Details]
Beddy, D,Watson, RWG,Fitzpatrick, JM,O'Connell, PR (2004) BRITISH JOURNAL OF SURGERY Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease , pp.72-77 [DOI] [Details]
Mahony, RT,Malone, PA,Nalty, J,Behan, M,O'Connell, PR,O'Herlihy, C (2004) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Randomized clinical trial of intra-anal electromyographic biofeedback physiotherapy with intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter in the early treatment of postpartum fecal incontinence , pp.885-890 [DOI] [Details]
Mulsow, JJW,Watson, RWG,Fitzpatrick, JM,O'Connell, PR (2005) ANNALS OF SURGERY Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling , pp.880-889 [DOI] [Details]
Jones, J.F.X., Shakespeare, I., Healy, C.F., Mitchell, P., Whealan, R., O'Herlihy, C. O'Connell, P.R.; (2005) Neural Control of rat external anal sphincter: a role for nitric oxide? Irish Society of Gastroenterology [Details]
Eogan, M., O'Brien, C., Daly, L., Byrne, P., O'Connell, P.R. O'Herlihy, C.; (2006) Monitoring pudendal nerve conduction during labour and the early puerperium Society of Maternal Fetal Medicine [Details]
Healy, C.F., Jones, J.F.X., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The development of an acute animal model to simulate pelvic floor injury during childbirth The Society of Academic Research in Surgery [Details]
Healy, C.F., Jones, J.F.X, O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The development of an acute animal model to simulate pelvic floor injury during childbirth Society of Coloproctology of Great Britain and Ireland [Details]
Healy, C.F., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The effects of obstetric trauma on the pudendal nerve - early report on the development of an acute animal model to simulate the anatomical distortions associated with childbirth Sylvestor O'Halloran Surgical Scientific Meeting [Details]
Healy, C.F., Jones, J.F.X., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The development of an acute animal model to simulate pelvic floor injury during childbirth Royal Academy of Medicine Ireland (RAMI) Winner of Registrar's Prize, Royal College of Surgeons [Details]
Healy, C.F., Jones, J.F.X., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The development of an acute animal model to simulate pelvic floor injury during childbirth The Association of Coloproctology of Great Britain and Ireland Annual Meeting [Details]
Eogan, M,Daly, L,O'Connell, PR,O'Herlihy, C (2006) BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Does the angle of episiotomy affect the incidence of anal sphincter injury? , pp.190-194 [DOI] [Details]
Brennan, DJ,Moynagh, M,Brannigan, AE,Gleeson, F,Rowland, M,O'Connell, PR (2007) DISEASES OF THE COLON & RECTUM Routine mobilization of the splenic flexure is not necessary during anterior resection for rectal cancer , pp.302-307 [DOI] [Details]
Healy, CF,O'Herlihy, C,O'Brien, C,O'Connell, PR,Jones, JFX (2008) DISEASES OF THE COLON & RECTUM Experimental Models of Neuropathic Fecal Incontinence: An Animal Model of Childbirth Injury to the Pudendal Nerve and External Anal Sphincter , pp.1619-1625 [DOI] [Details]
Burke, JP,Watson, RWG,Murphy, M,Docherty, NG,Coffey, JC,O'Connell, PR (2009) BRITISH JOURNAL OF SURGERY Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta 1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]
Peirce, C,Healy, CF,O'Herlihy, C,O'Connell, PR,Jones, JFX (2009) DISEASES OF THE COLON & RECTUM Reduced Somatosensory Cortical Activation in Experimental Models of Neuropathic Fecal Incontinence , pp.1417-1422 [DOI] [Details]
Peirce C, O¿Herlihy, C O¿Connell PR, Jones JFX. ; (2010) Faecal incontinence: where is the sense in it all? Irish Journal of Medical Science 2010, Vol 179, supplement 1, S1 Irish Journal of Medical Science 2010 [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, B,Coffey, JC,O'Connell, PR (2010) DISEASES OF THE COLON & RECTUM Desulfovibrio Bacterial Species Are Increased in Ulcerative Colitis , pp.1530-1536 [DOI] [Details]
Griffin, KM,O'Herlihy, C,O'Connell, PR,Jones, JFX (2012) DISEASES OF THE COLON & RECTUM Combined Ischemic and Neuropathic Insult to the Anal Canal in an Animal Model of Obstetric-Related Trauma , pp.32-41 [DOI] [Details]
Balfe A, Lennon G, Lavelle A, Docherty NG, Coffey JC, Winter D, O'Connell PR (2014) Isolation of homogenous population of epithelial cells from mucosal biopsies European Society of Coloproctology [Details]
Lennon G, Lavelle A, Balfe A, Docherty NG, Coffey JC, Winter D, O'Connell PR (2104) The gut microbiota: spatial ecology and community organization in health and ulcerative colitis European Society of Coloproctology [Details]
Pierce C, Alexander LE, Buffini, M. O'Herlihy C, O'Connell PR, Jones JF.; (2009) Investigation of the nerve supply to the external anal sphincter (EAS) in the female rat.96(S5) :37 British Journal of Surgery [Details]
Peirce C, Alexander LE, O'Herlihy C, O'Connell PR, Jones JFX; (2009) Activating transcription factor 3 (ATF-3) as a marker of injury in experimental models of neuropathic faecal Irish Journal of Medical Science [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) The British journal of surgery Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) The British journal of surgery Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease , pp.1290-1296 [DOI] [Details]
   

Editorial

O'Connell, PR (2012) The Effects of Age and Parity on Anorectal Function. Editorial [DOI] [Details]
O'Connell, PR (2012) Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipation (Br J Surg 2012; 99: 1002-1010). Editorial [DOI] [Details]
O'Connell, PR (2013) Sacral nerve stimulation for constipation (Br J Surg2013; 100: 174-181). Editorial [DOI] [Details]
O'Connell, PR; (2011) Suboptimal outcome following sacral nerve stimulation for faecal incontinence (Br J Surg 2011; 98: 140-147). Editorial [DOI] [Details]
                 

Abstract

Duffy, MM,Regan, MC,Harrington, MG,OConnell, PR (1996) Enteric mucosal metabolism is reduced in ileal reservoir mucosa. Abstract [Details]
Duffy, MM,Regan, MC,Harrington, MG,OConnell, PR (1996) Colonic substrate utilisation in Crohn's disease. Abstract [Details]
Kavanagh, EG,Watson, RW,Lederer, JA,Fitzpatrick, JM,O'Connell, PR (2001) Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis. Abstract [Details]
Beddy, D,Watson, RWG,Fitzpatrick, JM,O'Connell, PR (2003) TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease. Abstract [Details]
Beddy, D,Watson, RWG,Fitzpatrick, JM,O'Connell, PR (2003) Increased VEGF production in fibroblasts isolated from patients with Crohn's disease. Abstract [Details]
Mahony, R,Fitzpatrick, N,Kirwan, C,O'Connell, PR,O'Herlihy, C (2003) Review of four hundred women presenting after a third-degree tear. Abstract [Details]
Mahony, R,Malone, P,Nalty, J,Cassidy, M,O'Connell, PR,O'Herlihy, C (2003) Prospective randomized comparison of intra-anal electromyographic biofeedback and intra-anal electromyographic biofeedback augmented with electrical stimulation of the anal sphincter. Abstract [Details]
Eogan, M,O'Brien, C,Behan, M,O'Connell, PR,O'Herlihy, C (2003) Long-term effects of childbirth on fecal continence and pudendal nerve function. Abstract [Details]
Eogan, M,O'Brien, C,Daly, L,Byrne, P,O'Connell, PR,O'Herlihy, C (2005) Monitoring pudendal nerve conduction during labor and early puerperium. Abstract [Details]
Docherty, NG,Cunningham, MF,Toivonen, T,Cottell, DC,Burke, JP,O'Connell, PR (2010) S100A4 expression in fibrostenosing crohn's disease: evidence for a role in T-lymphocytes and fibroblasts but not in epithelial-mesenchymal transition. Abstract [Details]
Peirce, C,O'Herlihy, C,O'Connell, PR,Jones, JFX (2010) FAECAL INCONTINENCE: WHERE IS THE SENSE IN IT ALL?. Abstract [Details]
Griffin, KM,O'Herlihy, C,O'Connell, PR,Jones, JFX (2010) BRIEF SACRAL NERVE ROOT STIMULATION INCREASES CORTICAL SOMATOSENSORY POTENTIAL EVOKED BY ELECTRICAL STIMULATION OF THE ANAL CANAL IN AN EXPERIMENTAL MODEL. Abstract [Details]
Peirce, C,O'Herlihy, C,O'Connell, PR,Jones, JFX (2010) Faecal incontinence: are we losing our senses?. Abstract [Details]
Soetan, BK,O'Halloran, KD,O'Connell, PR,Jones, JFX (2011) BEHAVIOURAL STUDIES OF FAECAL CONTINENCE IN RAT. Abstract [Details]
Peirce, C,Murphy, C,Cassidy, M,Fitzpatrick, M,O'Connell, PR,O'Herlihy, C (2011) A randomised controlled trial comparing early home biofeedback physiotherapy with pelvic floor exercises following repair of third degree obstetric tears. Abstract [Details]
Buffini, M,O'Halloran, KD,O'Herlihy, C,O'Connell, PR,Jones, JFX (2011) COMPARISON OF THE MOTOR DISCHARGE TO THE VOLUNTARY SPHINCTERS OF CONTINENCE IN ANAESTHETIZED RATS. Abstract [Details]
Evers, J,Carrington, EV,Scott, SM,Knowles, CH,O'Connell, PR,Jones, JFX (2013) Comparison of anal evoked potentials elicited by mechanical and electrical stimuli in anaesthesised rats. Abstract [Details]
O¿Connell PR; (2009) STAPLED HAEMORRHOIDOPEXY FOR THE TREATMENT OF HAEMORRHOIDS: A SYSTEMATIC REVIEW¿. Abstract [Details]
       

Reviews

Mulsow, J,Winter, DC,O'Keane, JC,O'Connell, PR (2003) Sentinel lymph node mapping in colorectal cancer. Reviews [DOI] [Details]
McNamara, DA,Fitzpatrick, JM,O'Connell, PR (2003) Urinary tract involvement by colorectal cancer. Reviews [DOI] [Details]
McGuire, BB,Brannigan, AE,O'Connell, PR (2007) Ileal pouch-anal anastomosis. Reviews [DOI] [Details]
Burke, JP,Mulsow, JJ,O'Keane, C,Docherty, NG,Watson, RWG,O'Connell, PR (2007) Fibrogenesis in Crohn's disease. Reviews [DOI] [Details]
Coffey, JC,Rowan, F,Burke, J,Dochery, N,Kirwan, WO,O'Connell, PR (2009) Pathogenesis of and Unifying Hypothesis for Idiopathic Pouchitis. Reviews [DOI] [Details]
O'Riordan, JM,Margey, RJ,Blake, G,O'Connell, PR (2009) Antiplatelet Agents in the Perioperative Period. Reviews [Details]
Rowan, FE,Docherty, NG,Coffey, JC,O'Connell, PR (2009) Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis. Reviews [DOI] [Details]
Medani, M,Collins, D,Docherty, NG,Baird, AW,O'Connell, PR,Winter, DC (2011) Emerging Role of Hydrogen Sulfide in Colonic Physiology and Pathophysiology. Reviews [DOI] [Details]
                                                   

Letters

Beddy, D,Watson, RWG,Fitzpatrick, JM,O'Connell, PR (2004) Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply. Letters [DOI] [Details]
O'Brien, C,O'Herlihy, C,O'Connell, PR (2004) Pudendal neuropathy is best determined by full neurophysiologic assessment. Letters [DOI] [Details]
Peirce, C,Healy, CF,O'Herlihy, C,O'Connell, PR,Jones, JFX (2008) Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model. Letters [Details]
Coffey, JC,Docherty, NG,O'Connell, PR (2009) Hydrogen Sulphide: An Increasing Need for Scientific Equipoise. Letters [DOI] [Details]
Burke, JP,Coffey, JC,O'Connell, PR (2010) Authors' reply: Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts (Br J Surg 2010; 97: 1126-1134). Letters [DOI] [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR (2011) Ileal Pouch Microbial Diversity. Letters [DOI] [Details]

Research

Research Interests

FUNDING
Current Active Grants:

1) Science Foundation Ireland  2010-2016 -  ¿647,750 (co-investigator Prof D Winter) (09/IN.I/B2606)Colonisation by sulphate reducing bacteria subspecies in normal and inflamed human colon  

2) Bowel Disease Research Foundation 2009-2010, ¿35,000 Colonisation by sulphate reducing bacteria subspecies in normal and inflamed colon. 

 3) Science Foundation Ireland 2011 -2015     ¿156,000 (co-investigator, Dr James Jones) (11/RFP/3115)  

 The effect of sacral neuromodulation on inputs to the somatosensory cortex

4) Medtronic Corporation 2012-14 ¿200,000
Animal models of continence and neuromodulation 

 

 

 

 

 

 

 

3) Health Research Board HRB/2007/1152007 - 2010 ¿172,000 The mechanism of action of sacral root stimulation in an animal model of neuropathic faecal incontinence Co-investigators Prof Colm O'Herlihy, Dr James Jones)

 

 

 


Research Projects

Sponsor : Mater Misericordiae University Hospital
Title : The effect of pudendal nerve injury on sensory neurons in an animal model of neuropathic faecal incontinence
Start Date / End Date : 01-OCT-08 / 01-OCT-09
Sponsor : Science Foundation Ireland (SFI)
Title : Colonisation by sulphate reducing bacteria (SRB) subspecies in normal and inflamed colon and colonocyte responses to the SRB metabolite hydrogen sulphide
Start Date / End Date : 10-JUL-10 / 10-JUL-15
Sponsor : Science Foundation Ireland (SFI)
Title : Colonisation by sulphate reducing bacteria (SRB) subspecies in normal and inflamed colon and colonocyte responses to the SRB metabolite hydrogen sulphide
Start Date / End Date : 10-JUL-10 / 10-JUL-15
Sponsor : Health Research Board (HRB)
Title : The effect of CTGF polymorphisms on surgical recurrence following terminal ileal resection for Crohn¿s disease.
Start Date / End Date : 30-JUL-12 / 21-SEP-12

Recent Postgraduates

Current Postgraduate Students:
PhD year1 - 1
PhD year 3 - 1
MD year 1 - 2
MD year 3 + 1
MSc year 1 - 1
MCh year 1 - 1
MAO year 2 - 2

 

Collaborators

Internal Collaborators

Prof Colm O'Herlihy, Professor of Obsteterics and Gynaecology

Dr James Jones, Senior Lecture in Physiology

Prof Desmond Winter, Dept of Surgery St Vincent's University Hopsital

Prof John Hyland, Dept of Surgery, St Vincent's University Hospital

External Collaborators

Prof Gert van Asche, University Leuven, Belgium

Prof Soren Laurberg, University Aarhus, Denmark

Prof Steve Collins, MacMaster University, Hamilton, Ontario, Canada

Mr Charles H Knowles, Barts and the London School of Medicine, London, UK

Prof Fergus Shanahan, University College Cork

Dr Paul Ross, APC Centre, Teagasc, Fermoy, Co Cork

Dr Neil Docherty, Dept of Physiology, Trinity College Dublin