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Stephen Roy Pennington

Professor of Proteomics

School Of Medicine & Medical Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166783
Email: stephen.pennington@ucd.ie

Biography

Steve graduated from Imperial College of Science and Technology (University of London) with a joint honours degree in Chemistry and Biochemistry (upper second) before completing a PhD in Biochemistry at the University of Cambridge.  During his PhD he was awarded an Elmore Medical Research Fellowship.  It was during this fellowship that his interests in the regulation of the mammalian cell cycle began, the subject of his research that was continued when he moved the Department of Human Anatomy & Cell Biology at the University of Liverpool to take up a post as a Wellcome Trust funded lecturer.  Subsequently he was a University Lecturer and then Senior Lecturer.  During this period his research included the use of two-dimensional gel electrophoresis (2-DE) which was subsequently combined with mass spectrometry for protein characterisation.  Steve has been active in the practical implementation of collaborative proteomics projects and set up a multi-user proteomics facility at the University of Liverpool that served as a 'prototype' for the facility he established when he moved to the Conway Institute in 2003. Stephen¿s vision for the development of proteomics in UCD has been to use his expertise and experience to apply proteomics (in its broadest definition) to a diverse range of research programmes. Of particular interest to Steve's is the development of translational clinical translational projects that align research results to the clinical setting and the development of methods for the discovery and subsequent quantitative measurement of proteomic biomarkers.

Steve has received a Sir Henry Wellcome Commemorative Award for Innovative Research, has been Director of Research and member of the Board of a Cambridge-based seed-corn funded fledgling biotech company and has served in small scale consultancy capacities for a number of commercial organizations. He has given many presentations in the UK, Europe, the US and Asia including two industry funded lecture tours of Asia where he gave presentations in Taiwan, South Korea, Hong Kong and mainland China.

He is on the editorial board of several journals including in a more senior capacity for 'Proteomics' and the 'Journal of Proteomics' and regularly reviews manuscripts and grants for a number of international organisations.

Professional

         

Conference Contributions

O'Connor, D. P., O'Donoghue, N., Currid, C. A., Chang, B.-D., Roninson, I. B., Dunn, M. J., Pennington, S. R., and Gallagher, W. M. ; (2006) p21, p16 and p27, more than just cell cycle inhibitors. [Poster Presentation], Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway , 03-MAR-06 - 04-MAR-06.
   

Education

Year 1986 Institution: University of Cambridge
Qualification: PhD Subject:
Year 1982 Institution: University of London
Qualification: BSc Subject:
         

Publications

 

Book Chapters

Collins, B. C., Lau, T. Y. K., Pennington, S. R., and Gallagher, W. M. ; (2011) 'Differential proteomics incorporating iTRAQ labelling and multi-dimensional separations' In: Jean-Charles Gautier (eds). Methods in Molecular Biology - Drug Safety Evaluation. N/A: Humana Press. Available Online [DOI] [Details]
Lau, T. Y. K., Collins, B. C., Stone, P., Tang, N., Gallagher, W. M., and Pennington, S. R. ; (2011) 'Absolute quantification of toxicological biomarkers via multiple reaction monitoring' In: Gautier, J.-C (eds). Methods in Molecular Medicine - Drug Safety Evaluation. New York: Humana Press. Available Online [Details]
Dunn, M.J., Pennington, S.R.; (2006) 'Separation-dependent approaches for protein expression profiling' In: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Chichester: Wiley. [Details]

Edited Books

Pennington, S.R and Dunn, M.J (Ed.). (2000) Proteomics: from protein structure to function. UK: BIOS Scientific. [Details]

Peer Reviewed Journals

Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH,von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ (2011) 'Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus'. Proteomics, 11 (21):4189-4201. [DOI] [Details]
Gibson DS, Newell K, Evans AN, Finnegan S, Manning G, Scaife C, McAllister C, Pennington SR, Duncan MW, Moore TL, Rooney ME (2012) 'Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis'. Proteomics, 75 (17):5479-5492. [DOI] [Details]
Gibson DS, Rooney ME, Finnegan S, Qiu J, Thompson DC, Labaer J, Pennington SR, Duncan MW (2012) 'Biomarkers in rheumatology, now and in the future'. Rheumatology (Oxford, England), 51 (3):423-433. [DOI] [Details]
Herbert AP, Riesen M, Bloxam L, Kosmidou E, Wareing BM, Johnson JR, Phelan MM, Pennington SR, Lian LY, Morgan A (2012) 'NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast'. PLoS ONE, 7 (7). [DOI] [Details]
Doyle MS, Collins ES, Fitzgerald OM, Pennington SR (2012) 'New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis'. Arthritis Research & Therapy, 14 (5). [DOI] [Details]
Collins BC, Miller CA, Sposny A, Hewitt P, Wells M, Gallagher WM, Pennington SR (2012) 'Development of a pharmaceutical hepatotoxicity biomarker panel using a discovery to targeted proteomics approach'. Molecular & Cellular Proteomics, . [DOI] [Details]
Oon SF, Pennington SR, Fitzpatrick JM, Watson RW; (2011) 'Biomarker research in prostate cancer-towards utility, not futility'. Nature reviews. Cancer, 8 (3):131-138. [Details]
Dasari, S., Chambers, M. C., Codreanu, S. G., Liebler, D. C., Collins, B. C., Pennington, S. R., Gallagher, W. M. and Tabb, D. L. ; (2011) 'Sequence tagging reveals unexpected modifications in toxicoproteomics'. Chemical research in toxicology, 24 (2):204-216. [Details]
Lau, T. Y., Power, K. A., Dijon, S, de Gardelle, I., McDonnell, S., Duffy, M., Pennington, S., and Gallagher, W. M. ; (2010) 'Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression towards clinical verification'. Journal of Proteome Research, 9 :1450-1459. [Details]
Collins, B,Sposny, A,McCarthy, D,Brandenburg, A,Woodbury, R,Pennington, SR,Gautier, JC,Hewitt, P,Gallagher, WM; (2010) 'Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: A multi-site, multi-compound study'. Proteomics, 10 :1592-1608. [DOI] [Details]
Young LS, McIlroy M, McCartan D, Early S, O Gaora P, Pennington S, Hill AD, ; (2010) 'Interaction of developmental transcription factor HOX11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer'. Cancer Research, 70 (4):1585-1594. [DOI] [Details]
Gibson, DS,Finnegan, S,Jordan, G,Scaife, C,Brockbank, S,Curry, J,McAllister, C,Pennington, S,Dunn, M,Rooney, ME; (2009) 'Stratification and Monitoring of Juvenile Idiopathic Arthritis Patients by Synovial Proteome Analysis'. Journal of Proteome Research, 8 :5601-5609. [DOI] [Details]
Bane FT, Bannon JH, Pennington SR, Campiani G, Williams DC, Zisterer DM, Mc Gee MM,; (2009) 'The microtubule-targeting agents, PBOX-6 and paclitaxel, induce nuclear-cytoplasmic redistribution of the peptidyl prolyl isomerases, cyclophilin A and pin1, in malignant haematopoietic cells'. Journal of Pharmacology and Experimental Therapeutics, 329 :38-47. [DOI] [Details]
Gallagher WM, Lau TY, O'Connor DP, Brennan DJ, Duffy MJ, Pennington SR, ; (2007) 'Breast cancer proteomics: clinical perspectives'. Expert Opinion on Biological Therapy, 2 (NA):209-219. [DOI] [Details]
Downes, MR; Byrne, JC; Pennington, SR; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; ; (2007) 'Urinary markers for prostate cancer'. British Journal of Urology, 99 (2):263-268. [Details]
Govender P, Baugh JA, Pennington SR, Dunn MJ, Donnelly SC. ; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Review of Proteomics, 4 (3):379-388. [Details]
Pennington SR, Collins BC, Clarke A, Kitteringham NR, Gallagher WM, ; (2007) 'Use of proteomics for the discovery of early markers of drug toxicity'. Expert Opinion on Drug Metabolism & Toxicology, 5 (NA):689-704. [DOI] [Details]
Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; ; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular & Cellular Proteomics, 5 (10):71-71. [Details]
Collins, BC; O'Connor, DP; Currid, CC; O'Donoghue, N; Pedersen, K; Dunn, MJ; Pennington, SR; Roninson, IB; Gallgher, WM; ; (2006) 'Proteomic analysis of cyclin-dependent kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-gel electrophoresis/peptide mass fingerprinting'. Molecular & Cellular Proteomics, 5 (10):101-101. [Details]
Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; ; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular & Cellular Proteomics, 5 (10):71-71. [Details]
Downes, MR; Byrne, JC; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: A review'. Biomarkers, 11 (5):406-416. [Details]
Zintl, A; Pennington, SR; Mulcahy, G; ; (2006) 'Comparison of different methods for the solubilisation of Neospora caninum (Phylum Apicomplexa) antigen'. Veterinary Parasitology, 135 (3-4):205-213. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology Supplements, 5 (14):789-789. [Details]
Wilkins, MR,Appel, RD,Van Eyk, JE,Chung, MCM,Gorg, A,Hecker, M,Huber, LA,Langen, H,Link, AJ,Paik, YK,Patterson, SD,Pennington, SR,Rabilloud, T,Simpson, RJ,Weiss, W,Dunn, MJ; (2006) 'Guidelines for the next 10 years of proteomics'. Proteomics, 6 :4-8. [DOI] [Details]
Jenkins, RE,Kitteringham, NR,Hunter, CL,Webb, S,Hunt, TJ,Elsby, R,Watson, RB,Williams, D,Pennington, SR,Park, BK; (2006) 'Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags'. Proteomics, 6 :1934-1947. [DOI] [Details]
Barker, CR,Hamlett, J,Pennington, SR,Burrows, F,Lundgren, K,Lough, R,Watson, AJM,Jenkins, JR; (2006) 'The topoisomerase II-Hsp90 complex: A new chemotherapeutic target?'. International Journal of Cancer, 118 :2685-2693. [DOI] [Details]
Currid, CA,O'Connor, DP,Chang, BD,Gebus, C,Harris, N,Dawson, KA,Dunn, MJ,Pennington, SR,Roninson, IB,Gallagher, WM; (2006) 'Proteomic analysis of factors released from p21-overexpressing tumour cells'. Proteomics, 6 (NA):3739-3753. [DOI] [Details]
Focking, M,Boersema, PJ,O'Donoghue, N,Lubec, G,Pennington, SR,Cotter, DR,Dunn, MJ; (2006) '2-D DIGE as a quantitative tool for investigating the HUPO Brain Proteome Project mouse series'. Proteomics, 6 :4914-4931. [DOI] [Details]
Gallagher, WM; Lynch, I; Allen, LT; Miller, I; Penney, SC; O'Connor, DP; Pennington, S; Keenan, AK; Dawson, KA; ; (2006) 'Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies'. Biomaterials, 27 (35):5871-5882. [Details]
Downes, MR; Watson, WG; Byrne, JC; Fitzpatrick, JM; Dunn, MJ; Pennington, SR; ; (2006) 'Urinary markers in the diagnosis of prostate cancer'. Molecular & Cellular Proteomics, 5 (10):74-74. [Details]
Gibson, DS; Blelock, S; Curry, J; Healy, A; Scaife, C; McAllister, C; Pennington, S; Dunn, M; Rooney, M; ; (2006) 'Biomarkers of disease progression in Juvenile idiopathic arthritis patients'. Molecular & Cellular Proteomics, 5 (10):138-138. [Details]
Gibson, DS; Blelock, S; Curry, J; Healy, A; Dunn, M; Pennington, S; Rooney, ME; ; (2006) 'Identification of proteomic biomarkers to predict progression in juvenile idiopathic arthritis'. Arthritis and Rheumatism, 54 (9):693-693. [Details]
Hamacher, M.,Apweiler, R.,Arnold, G.,Becker, A.,Bluggel, M.,Carrette, O.,Colvis, C.,Dunn, M. J.,Frohlich, T.,Fountoulakis, M.,van Hall, A.,Herberg, F.,Ji, J.,Kretzschmar, H.,Lewczuk, P.,Lubec, G.,Marcus, K.,Martens, L.,Palacios Bustamante, N.,Park, Y. M.,Pennington, S. R.,Robben, J.,Stuhler, K.,Reidegeld, K. A.,Riederer, P.,Rossier, J.,Sanchez, J. C.,Schrader, M.,Stephan, C.,Tagle, D.,Thiele, H.,Wang, J.,Wiltfang, J.,Yoo, J. S.,Zhang, C.,Klose, J.,Meyer, H. E.; (2006) 'HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy'. Proteomics, 6 (18):4890-8. [Details]
Gibson, D. S.,Blelock, S.,Curry, J.,Finnegan, S.,Healy, A.,Scaife, C.,McAllister, C.,Pennington, S.,Dunn, M.,Rooney, M.; (2009) 'Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis--proteomic patterns of joint inflammation in early stage disease'. J Proteomics, 72 (4):656-76. Available Online [Details]
Gautier, V. W.,Gu, L.,O'Donoghue, N.,Pennington, S.,Sheehy, N.,Hall, W. W.; (2009) 'In vitro nuclear interactome of the HIV-1 Tat protein'. Retrovirology, 6 . Available Online [Details]
Goodwin, R. J.,Pennington, S. R.,Pitt, A. R.; (2008) 'Protein and peptides in pictures: imaging with MALDI mass spectrometry'. Proteomics, 8 (18):3785-800. Available Online [Details]
Pennington, S. R.,Foster, B. J.,Hawley, S. R.,Jenkins, R. E.,Zolle, O.,White, M. R.,McNamee, C. J.,Sheterline, P.,Simpson, A. W.; (2007) 'Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts'. Journal of Biological Chemistry, 282 (44):32112-20. Available Online [Details]
Shekouh, A. R.,Thompson, C. C.,Prime, W.,Campbell, F.,Hamlett, J.,Herrington, C. S.,Lemoine, N. R.,Crnogorac-Jurcevic, T.,Buechler, M. W.,Friess, H.,Neoptolemos, J. P.,Pennington, S. R.,Costello, E.; (2003) 'Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma'. Proteomics, 3 (10):1988-2001. Available Online [Details]
Noble, P. J.,Wilde, G.,White, M. R.,Pennington, S. R.,Dockray, G. J.,Varro, A.; (2003) 'Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways'. Am J Physiol Gastrointest Liver Physiol, 284 (1):G75-84. Available Online [Details]
Kitteringham, N. R.,Powell, H.,Jenkins, R. E.,Hamlett, J.,Lovatt, C.,Elsby, R.,Henderson, C. J.,Wolf, C. R.,Pennington, S. R.,Park, B. K.; (2003) 'Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver'. Proteomics, 3 (2):191-207. Available Online [Details]
Ivings, L.,Pennington, S. R.,Jenkins, R.,Weiss, J. L.,Burgoyne, R. D.; (2002) 'Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin'. Biochem J, 363 (Pt 3):599-608. Available Online [Details]
Jenkins, R. E.,Pennington, S. R.; (2001) 'Arrays for protein expression profiling: towards a viable alternative to two-dimensional gel electrophoresis?'. Proteomics, 1 (1):13-29. Available Online [Details]
Jenkins, R. E.,Hawley, S. R.,Promwikorn, W.,Brown, J.,Hamlett, J.,Pennington, S. R.; (2001) 'Regulation of growth factor induced gene expression by calcium signalling: integrated mRNA and protein expression analysis'. Proteomics, 1 (9):1092-104. Available Online [Details]
Promwikorn, W.,Hawley, S. R.,Pennington, S. R.; (2000) 'Changes in p21(Cip1) and p27(Kip1) expression are not required for cell cycle entry and progression to S phase in Swiss 3T3 cells'. Cell Signal, 12 (9-10):619-27. Available Online [Details]
Hamlett, J.,Hawley, S. R.,Pennington, S. R.; (2000) 'Mastoparan transiently permeabilizes Swiss 3T3 cells and induces c-fos proto-oncogene expression. Role of calcium and G protein activation'. Cell Signal, 12 (4):239-44. Available Online [Details]
Hawley, S. R.,Pennington, S. R.; (1998) 'Attachment staining: a novel method for flow cytometric quantitation of protein expression in limited numbers of adherent cells'. Cytometry, 32 (3):198-205. Available Online [Details]
Pennington, S. R.,Wilkins, M. R.,Hochstrasser, D. F.,Dunn, M. J.; (1997) 'Proteome analysis: from protein characterization to biological function'. Trends Cell Biol, 7 (4):168-73. Available Online [Details]
Gilroy, S. J.,Salmons, S.,Pennington, S. R.; (1997) 'Changes in nuclear protein composition in response to chronic electrical stimulation of skeletal muscle'. Electrophoresis, 18 (5):809-13. Available Online [Details]
Saurin, A. J.,Hamlett, J.,Clague, M. J.,Pennington, S. R.; (1996) 'Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts'. Biochem J, 313 ( Pt 1) :65-70. Available Online [Details]
Pullan, S.,Pennington, S. R.; (1996) 'Mastoparan causes cell permeabilisation and delayed activation of DNA synthesis in Swiss 3T3 fibroblasts'. Cell Signal, 8 (7):481-5. Available Online [Details]
Pennington, S. R.; (1995) 'GTP-binding proteins 1: heterotrimeric G proteins'. Protein Profile, 2 (3):167-315. Available Online [Details]
Bedells, C. H.,Pennington, S. R.; (1995) 'Analysis of growth factor stimulated nucleocytoplasmic protein transport using two-dimensional gel electrophoresis'. Electrophoresis, 16 (7):1231-9. Available Online [Details]
Pennington, S. R.; (1994) 'GTP-binding proteins. 1: heterotrimeric G proteins'. Protein Profile, 1 (3):169-342. Available Online [Details]
Pennington, S.; (1994) '2-D protein gel electrophoresis: an old method with future potential'. Trends Cell Biol, 4 (12):439-41. Available Online [Details]
Schofl, C.,Cuthbertson, K. S.,Gallagher, J. A.,Pennington, S. R.,Cobbold, P. H.,Brabant, G.,Hesch, R. D.,von zur Muhlen, A.; (1991) 'Measurement of intracellular Ca2+ in single aequorin-injected and suspensions of fura-2-loaded ROS 17/2.8 cells and normal human osteoblasts. Effect of parathyroid hormone'. Biochem J, 274 ( Pt 1) :15-20. Available Online [Details]
Pennington, S. R.,Moore, J. P.,Hesketh, T. R.,Metcalfe, J. C.; (1990) 'Mitogen-stimulated activation of the Na+/H+ antiporter does not regulate S6 phosphorylation or protein synthesis in murine thymocytes or Swiss 3T3 fibroblasts'. J Biol Chem, 265 (5):2456-61. Available Online [Details]
Hesketh, R.,Moore, T. A.,Pennington, S. R.,Smith, G. A.,Metcalfe, J. C.; (1990) 'Analysis of the primary signals required for activation of the mitogenic pathway in murine thymocytes from protein phosphorylation patterns'. J Immunol, 145 (8):2571-80. Available Online [Details]
Pennington, S. R.,Hesketh, T. R.,Metcalfe, J. C.; (1988) 'GTP gamma S activation of proto-oncogene expression in transiently permeabilised Swiss 3T3 fibroblasts'. FEBS Lett, 227 (2):203-8. Available Online [Details]
Farndale, R. W.,Sandy, J. R.,Atkinson, S. J.,Pennington, S. R.,Meghji, S.,Meikle, M. C.; (1988) 'Parathyroid hormone and prostaglandin E2 stimulate both inositol phosphates and cyclic AMP accumulation in mouse osteoblast cultures'. Biochem J, 252 (1):263-8. Available Online [Details]
Pennington, S. R.; (1987) 'G proteins and diabetes'. Nature, 327 (6119):188-9. Available Online [Details]
Pennington, S. R.,Martin, B. R.; (1985) 'Insulin-stimulated phosphoinositide metabolism in isolated fat cells'. J Biol Chem, 260 (20):11039-45. Available Online [Details]
Donoghue PM, McManus CA, O'Donoghue NM, Pennington SR, Dunn MJ.; (2006) 'CyDye immunoblotting for proteomics: co-detection of specific immunoreactive and total protein profiles'. Proteomics, 6 (24):6400-6424. [Details]
Downes, MR; Byrne, JC; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: A review'. Biomarkers, 11 (5):406-416. [Details]
Focking, M; Boersema, PJ; O'Donoghue, N; Lubec, G; Pennington, SR; Cotter, DR; Dunn, MJ; ; (2006) '2-D DIGE as a quantitative tool for investigating the HUPO Brain Proteome Project mouse series'. Proteomics, 6 (18):4914-4931. [Details]
Allen, LT; Tosetto, M; Miller, IS; O'Connor, DP; Penney, SC; Lynch, I; Keenan, AK; Pennington, SR; Dawson, KA; Gallagher, WM; ; (2006) 'Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction'. Biomaterials, 27 (16):3096-3108. [Details]
Greenough, C; Jenkins, RE; Kitteringham, NR; Pirmohamed, M; Park, BK; Pennington, SR; ; (2004) 'A method for the rapid depletion of albumin and immunoglobulin from human plasma'. Proteomics, 4 (10):3107-3111. [Details]

Other Journals

Dunn, MJ,Gil, C,Kleinhammer, C,Lottspeich, F,Pennington, S,Sanchez, JC,Albar, JP,Bini, L,Corrales, F,Corthals, GL,Fountoulakis, MM,Hoogland, C,James, P,Jensen, ON,Jimenez, C,Jorrin-Novo, J,Kraus, HJ,Meyer, H,Noukakis, D,Palagi, PM,Penque, D,Quinn, A,Rabilloud, T; (2008) 'EuPA achieves visibility - An activity report on the first three years' Proteomics 71 :11-18. [DOI] [Details]
Gibson, D. S., Blelock, S., Finnegan, S., Curry, J., Healy, A., Scaife, C., McAllister, C., Pennington, S., Dunn, M., Rooney, M., ; (2007) 'Fingerprinting the synovial proteome to stratify juvenile idiopathic arthritis patients' Annals of Rheumatic Diseases 66 :112-112. [Details]
Watson, W, Byrne, J, ODonogue, N, Dunn, M, Scaife, C, Fitzpatrick, J, Pennington, S, ; (2007) 'The prostate cancer research consortium: A bio-resource for the discovery of tissue and serum markers for prostate cancer' Anticancer Research 27 :1372-1372. [Details]
Hamacher, M., Stephan, C., Palacios Bustamante, N., van Hall, A., Marcus, K., Reidegeld, K.A., Gantly, A., Pennington, S.R., Dunn, M.J., Meyer, H.E.; (2006) 'Bridging Proteomics and Medical Science - the 5th HUPO Brain Proteome Workshop in Dublin, Ireland' Proteomics . [Details]

Conference Publications

Gibson, D. S., Blelock, S., Curry, J., Finnegan, S., Healy, A., Scaife, C., McAllister, C., Pennington, S., Dunn, M., Rooney, M., ; (2008) Rheumatology Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients , pp.27-27 [Details]
Monopoli MP, Pennington S, Dunn MJ, Murphy KJ ; (2007) Use of two dimensional electrophoresis to characterise the hippocampal memory consolidation proteome 8th IBRO congress [Details]
Nic Raghnaill, Monopoli MP, O'Sullivan NC, Loscher JS, Pennington S, Dunn MJ, Regan CM, Murphy KJ ; (2007) Hippocampal protein expression changes associated with consolidation of spatial memory characterised using two dimensional electrophoresis Society for Neuroscience Annual Meeting 2007 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Currid, C., O'Connor, D.P., Gebus, C., Chang, B.-D., Harris, N., Dawson, K., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2005) Proteomic analysis of factors released from p21-overexpressing tumour cells HUPO 4th Annual World Congress Berlin, Germany, , 28-AUG-05 - 01-SEP-05 [Details]
   

Editorial

Hamacher, M,Apweiler, R,Arnold, G,Becker, A,Bluggel, M,Carrette, O,Colvis, C,Dunn, MJ,Frohlich, T,Fountoulakis, M,van Hall, A,Herberg, F,Ji, J,Kretzschmar, H,Lewczuk, P,Lubec, G,Marcus, K,Martens, L,Bustamante, NP,Park, YM,Pennington, SR,Robben, J,Stuhler, K,Reidegeld, KA,Riederer, P,Rossier, J,Sanchez, JC,Schrader, M,Stephan, C,Tagle, D,Thiele, H,Wang, J,Wiltfang, J,Yoo, JS,Zhang, CG,Klose, J,Meyer, HE; (2006) HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Editorial [DOI] [Details]
       

Reports

Wilkins, M. R.,Appel, R. D.,Van Eyk, J. E.,Chung, M. C.,Gorg, A.,Hecker, M.,Huber, L. A.,Langen, H.,Link, A. J.,Paik, Y. K.,Patterson, S. D.,Pennington, S. R.,Rabilloud, T.,Simpson, R. J.,Weiss, W.,Dunn, M. J.; (2006) Guidelines for the next 10 years of proteomics. Reports Available Online [Details]
       

Abstract

Hamacher, M., Stephan, C., Palacios Bustamante, N., van Hall, A., Marcus, K., Reidegeld, K.A., Gantly, A., Pennington, S.R., Dunn, M.J., Meyer, H.E.; (2006) Bridging Proteomics and Medical Science - the 5th HUPO Brain Proteome Workshop in Dublin, Ireland. Abstract [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) Utilising proteomic platforms for the identification of novel serum markers of prostate cancer. Abstract [Details]
                                                               

Research

Research Interests

Our research interests and activities are joined by a common theme of measurement of protein expression and function on a comprehensive scale - proteomics. We are currently actively engaged in 'Biomarker Discovery and Development'

New and better biomarkers are urgently needed to improve diagnosis and clinical decision making in a wide range of diseases.  In recent years it has become increasingly appreciated that novel biomarkers may only be effective when assembled as groups or panels and the ¿omics are well-suited to deliver such multi-marker panels. 

Over a number of years we have established the infrastructure and teams, including clinical investigators, for the discovery of panels of proteomic biomarkers with the potential to support their subsequent translation to clinical utility. In key specific clinical areas - including inflammatory arthritis, breast cancer and prostate cancer, where there remains significant unmet need for new biomarkers of clinical importance -we have undertaken broad discovery programmes and identified panels of potential protein biomarker candidates.  Our approach has taken competitive advantage of the excellent local clinical bioresource infrastructure for access to clinical samples and a 'quantitative proteomics' mass spectrometry platform (nanoflow ESI Q-Tof and QQQ mass spectrometers) to support biomarker discovery and quantitative multiplexed measurement of protein expression. 


Research Projects

Sponsor : Applied Biosystems, USA
Title : Applied Biosystems Newman Fellowship in Proteomics
Start Date / End Date : 01-MAY-06 / 31-MAY-08
Sponsor : Cancer Research Ireland (CRI)
Title : Proteomic analysis of an EGFR antagonist on the combined hormonal therapy and radiation therapy of high risk localised prostate cancer
Start Date / End Date : 01-OCT-05 / 30-SEP-07
Sponsor : Science Foundation Ireland (SFI)
Title : Research Professorship in Biomedical Proteomics
Start Date / End Date : 01-NOV-04 / 30-APR-10
Sponsor : St Luke's Institute of Cancer Research
Title : Proteomic analysis of combined hormonal therapy and radiation therapy of high risk localised prostate cancer
Start Date / End Date : 01-APR-07 / 31-MAR-09
Sponsor : University College Dublin (UCD)
Title : Proteomics 2009 - "Technological Advances, Discovery and Validation"
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin Foundation Ltd.
Title : Quantitative Proteomics Platform
Start Date / End Date : 01-JAN-11 / 31-DEC-11
Sponsor : University College Dublin Foundation Ltd.
Title : Proteomic Analysis of Psoriatic Arthritis
Start Date / End Date : 05-APR-11 / 04-APR-12
Sponsor : Irish Cancer Society
Title : Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
Start Date / End Date : 01-OCT-11 / 30-SEP-14
Sponsor : Health Research Board (HRB)
Title : Protein expression profiles of morphologically discrete foci in prostate cancer
Start Date / End Date : 01-OCT-11 / 30-SEP-14
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of MMS
Start Date / End Date : 01-MAR-11 / 29-FEB-16
Sponsor : University College Dublin (UCD)
Title : Discovery and Validation of Biomarkers to Predict response in Inflammatory Arthritis
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Agilent Technologies Ireland Ltd.
Title : Development of advanced methods and workflows to support discovery, validation and quantitative protein measurements
Start Date / End Date : 27-OCT-09 / 26-OCT-10
Sponsor : St Luke's Institute of Cancer Research
Title : Proteomic analysis of combined hormonal therapy and radiation therapy for localised prostate cancer.
Start Date / End Date : 01-NOV-09 / 30-APR-13
Sponsor : Teagasc
Title : Analysis pf the biochemical basis of meat quality/tenderness and its interaction with post slaughter interventions
Start Date / End Date : 01-JUN-06 / 31-JUL-10

Recent Postgraduates

Recent post-graduate students

Ben Collins
Eimear Downey
Tom Lau
Marco Monopoli 

Current Postgraduate Students

Claire Tonry, Master of Science (MSc)   -   Thesis Supervisor
Matthew Doyle, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Brian Morrissey, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Opeyemi Ademowo, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

Current teaching portfolio includes:

Undergraduate 

Module co-ordinator:

MDSA10210 Science, Medicine and Society  

PHYS40080  Clinical Biomarkers                             

Contribute to:

MDSA10180 Basic Principles of Cell Biology

MDSA10240 Molecules in Medicine

MDSA20210 Molecules in Medicine             

MDSA20220 Molecules in Medicine (PMC)

MDSA20170 Vascular Biology

PATH20130 Molecular Basis of Life and Disease (GEM)

PHYS20150  Cardiorespiratory Physiology

PATH30160  Cardiorespiratory Disease

PHYS40080  Clinical Biomarkers                             

Postgraduate

Contribute to:

CNWY40080 Introduction to Core Research Skills

CNWY40160 Applied Proteomics

CNWY40090 Introduction to ¿Omics

Graduate Certificate in Clinical & Translational

 

Modules Coordinated

201200   PATH40020     Pathology: Clinical Biomarkers
       

Collaborators

Internal Collaborators

Prof Oliver Fitzgerald, School of Medicine and Medical Science, St Vincent's University Hospital: proteomics of Psoriatic Arthritis

Prof WIlliam Watson, School of Medicine and Medical Science, UCD Conway Institute: prostate cancer consortium

Prof Stephen Gordon, School of Veterinary Medicine and Prof David McHugh, School of Agriculture & Food Science: biomarkers of TB

Dr John Baugh and Dr Chris Waston, School of Medicine and Medical Science, UCD Conway Institute: biomarkers of cardiovascular disease


External Collaborators

Prof John O'Leary, Trinity College Dublin: prostate cancer consortium
Prof Steve Finn, Trinity College Dublin: prostate cancer consortium

Dr Aviva Tolkovsky, Brain Repair Centre, University of Cambridge: tau interacting proteins

Dr Angela Mally, University of Wurzburg: pre-clinical toxicity markers

Dr David Gibson, Queen's University, Belfast