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Researchers at UCD

Walter McNicholas

Newman Clinical Research Professor

School Of Medicine & Medical Science
St Vincent's Hospital
Elm Park
Dublin 4

Tel: +353 1 716
Email: walter.mcnicholas@ucd.ie

Biography

PROFESSOR WALTER MCNICHOLAS MD, FRCPI, FRCPC, FCCP is Newman Professor in Clinical Research at UCD, Director of the Pulmonary and Sleep Disorders Unit and Consultant Respiratory Physician at St. Vincent’s University Hospital, Dublin. He is Past President of the European Respiratory Society, the British Sleep Society and the Irish Thoracic Society. He graduated in medicine (MB, BCh) from UCD in 1974 and was awarded the MD degree by thesis from UCD in 1982 on “The Pathophysiology of Sleep Apnoea”. Following postgraduate training and research at the University of Toronto (1977-1982), he established the Respiratory Sleep Research Laboratory at St. Vincent’s University Hospital in 1983. His research includes the molecular mechanisms of intermittent hypoxia, the pathophysiology, treatment and outcomes of sleep apnoea syndrome, the cardiovascular consequences of the disorder and sleep disturbances in COPD. He is also actively involved in the development of novel diagnostic systems for sleep disorders in collaboration with the School of Electronic Engineering and the UCD Campus Company Biancamed. He is Chair of the current EU COST Action on Obstructive Sleep Apnoea and is a past Associate Editor of the European Respiratory Journal. He has published over 150 full papers in International Peer-reviewed Journals in addition to editing two textbooks on breathing disorders in sleep and contributing 20 book chapters.

Professional

         

Conference Contributions

Sheridan, E., Heneghan, C., Nolan, P., Cullen, J., McNicholas, W., OMalley, M. J.,; Detection and analysis of electrocardiogram interval variations in normal sinus rhythm,. [National Refereed Conference Paper], Proceedings of the Irish Colloquim on DSP and Control, Dublin, July, 2000, Dublin .
Cullen, J.,Lowery, M.,McNicholas, W. T.,Nolan, P.,O'Malley, M.,O'Muircheartaigh, C.; (2001) XXXIV International Congress of Physiological Sciences. [Published Abstract], Optimisation of Electrode Design to Detect Myoelectric Manifestations of Fatigue in the Human Genioglossus Muscle, Christchurch, New Zealand .
               

Publications

Books

G. Parati, C. Lombardi, J. Hedner, M.R. Bonsignore, L. Grote, R. Tkacova, P. Levy, R. Riha, C. Bassetti, K. Narkiewicz, , G. Mancia, W. McNicholas. ; (2010) Consensus document on the management of patients with obstructive sleep apnea and hypertension. Joint recommendations by the European Cost Action B26, the European Society of Hypertension and the European Respiratory Society. Momento Medico (Salerno, Italy): Momento Medico. [Details]

Book Chapters

Bonsignore MR, McNicholas W.; (2009) 'PP179-204' In: Sleep-disordered breathing in the elderly. Respir Monograph 2009; 43: 179-204: Eur Respir Monograph. [Details]

Edited Books

Edited by Walter T. McNicholas and Marisa Bonsignore (Ed.). (2010) Sleep Apnoea. European Respiratory Monograph Series: European Respiratory Monograph Series. [Details]

Peer Reviewed Journals

Ryan, S,Garvey, JF,Swan, V,Behan, R,McNicholas, WT; (2011) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy'. Journal of Sleep Research, 20 :367-373. [DOI] [Details]
Lee, R,McNicholas, WT; (2011) 'Obstructive sleep apnea in chronic obstructive pulmonary disease patients'. Current opinion in pulmonary medicine, 17 :79-83. [DOI] [Details]
de Chazal P, Heneghan C, McNicholas WT.; (2009) 'Multimodal detection of sleep apnoea using electrocardiogram and oximetry signals'. Philos Transact A Math Phys Eng Sci, 367 (1887):369-389. [Details]
Kent BD, Ryan S, McNicholas WT; (2010) 'The genetics of obstructive sleep apnoea'. Current opinion in pulmonary medicine, 16 (6):536-542. [Details]
Ryan S, McNicholas W.; (2010) 'The effect of continuous positive airway pressure on C-reactive protein levels in patients with obstructive sleep apnea syndrome'. Chest, 137 (2):496-497. [Details]
Miller SD, Glynn SF, Kiely JL, McNicholas WT.; (2010) 'The role of nasal CPAP in obstructive sleep apnoea syndrome due to mandibular hypoplasia'. Respirology (Carlton, Vic.), 15 (2):377-379. [Details]
Garvey JF, McNicholas WT.; (2010) 'Continuous positive airway pressure therapy: new generations'. The Indian journal of medical research, 131 :259-266. [Details]
McNicholas WT, de Chazal P, Heneghan C, ; (2009) 'Multimodal detection of sleep apnoea using electrocardiogram and oximetry signals'. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 1887 (NA):369-389. [DOI] [Details]
de Chazal P, Fox N, O'Hare E, Heneghan C, Zaffaroni A, Boyle P, Smith S, O'Connell C, McNicholas WT.; (2010) 'Sleep/wake measurement using a non-contact biomotion sensor'. Journal of Sleep Research, . [Details]
Ryan S, Garvey JF, Swan V, Behan R, McNicholas WT; (2010) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy'. Journal of Sleep Research, . [Details]
McNicholas WT, ; (2009) 'Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180 (8):692-700. [DOI] [Details]
Riha, R. L.,McNicholas, W. T.; (2009) 'The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome'. Eur Respir J, 33 (2):233-6. Available Online [Details]
Garvey, J. F.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation'. Eur Respir J, 33 (5):1195-205. Available Online [Details]
Ryan, S.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?'. Thorax, 64 (7):631-6. Available Online [Details]
Zaffaroni A, de Chazal P, Heneghan C, Boyle P, Mppm PR, McNicholas WT. ; (2009) 'SleepMinder: an innovative contact-free device for the estimation of the apnoea-hypopnoea index'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009:7091-4 . [Details]
Chua EC, McSharry DG, McNicholas WT, Lowery MM. ; (2009) 'Towards a genioglossus surface EMG model of obstructive sleep apnea'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009:2979-82 . [Details]
Ryan, S,Doherty, LS,Nolan, GM,McNicholas, WT; (2009) 'Effects of Heated Humidification and Topical Steroids on Compliance, Nasal Symptoms, and Quality of Life in Patients with Obstructive Sleep Apnea Syndrome Using Nasal Continuous Positive Airway Pressure'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 5 :422-427. [Details]
Ryan, S.,Doherty, L. S.,Rock, C.,Nolan, G. M.,McNicholas, W. T.; (2009) 'Effects of Salmeterol on Sleeping Oxygen Saturation in Chronic Obstructive Pulmonary Disease'. Respiration, . Available Online [Details]
McNicholas WT, ; (2009) 'Obstructive sleep apnea and inflammation'. Progress in cardiovascular diseases, 5 (NA):392-399. [DOI] [Details]
Ryan, S.,McNicholas, W. T.; (2009) 'Inflammatory cardiovascular risk markers in obstructive sleep apnoea syndrome'. Cardiovasc Hematol Agents Med Chem, 7 (1):76-81. Available Online [Details]
Heneghan, C,Chua, CP,Garvey, JF,de Chazal, P,Shouldice, R,Boyle, P,McNicholas, WT; (2008) 'A portable automated assessment tool for sleep apnea using a combined Holter-oximeter'. Sleep, 31 (NA):1432-1439. [Details]
O' Donnell DH, Phelan S, McNicholas W, Gallagher CG, Crotty T, Dodd JD; (2010) 'Idiopathic lymphocytic pleuritis: radiographic and high-resolution CT appearances and changes in response to therapy in two adults'. Clinical Imaging, . [Details]
McNicholas WT, ; (2008) 'Diagnosis of obstructive sleep apnea in adults'. Proceedings of the American Thoracic Society, 2 (NA):154-160. [DOI] [Details]
McNicholas WT, Heneghan C, de Chazal P, Ryan S, Chua CP, Doherty L, Boyle P, Nolan P, ; (2008) 'Electrocardiogram recording as a screening tool for sleep disordered breathing'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 3 (NA):223-228. [Details]
Dodd JD, Harte S, McNicholas WT, Donnelly SC, ; (2008) 'Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults'. British Journal of Radiology, 81 (972):1-8. [DOI] [Details]
Harte, S.,McNicholas, W. T.,Donnelly, S. C.,Dodd, J. D.; (2008) 'Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults'. Br J Radiol, 81 (972):e295-8. Available Online [Details]
Heneghan, C.,Chua, C. P.,Garvey, J. F.,de Chazal, P.,Shouldice, R.,Boyle, P.,McNicholas, W. T.; (2008) 'A portable automated assessment tool for sleep apnea using a combined Holter-oximeter'. Sleep, 31 (10):1432-9. Available Online [Details]
Ryan, S.,McNicholas, W. T.; (2008) 'Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS'. Arch Physiol Biochem, 114 (4):261-6. Available Online [Details]
McNicholas, W., , ; (2008) 'Diagnosing the patient at risk of sleep-related respiratory insufficiency'. Multidisciplinary Respiratory Medicine, 3 (1):57-59. [Details]
McNicholas WT, ; (2007) 'Cardiovascular outcomes of CPAP therapy in obstructive sleep apnea syndrome'. American journal of physiology. Regulatory, integrative and comparative physiology, 4 (NA):1-70. [DOI] [Details]
McSharry, DG, McElwaine, P, Segadal, L, McNicholas, WT, ; (2007) 'All that wheezes is not asthma'. Lancet, 370 :800-800. [Details]
Ryan, S, Ward, S, Heneghan, C, McNicholas, WT, ; (2007) 'Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome'. Chest, 131 :1100-1107. [Details]
Alonderis, A.,Barbe, F.,Bonsignore, M.,Calverley, P.,De Backer, W.,Diefenbach, K.,Donic, V.,Fanfulla, F.,Fietze, I.,Franklin, K.,Grote, L.,Hedner, J.,Jennum, P.,Krieger, J.,Levy, P.,McNicholas, W.,Montserrat, J.,Parati, G.,Pascu, M.,Penzel, T.,Riha, R.,Rodenstein, D.,Sanna, A.,Schulz, R.,Sforza, E.,Sliwinski, P.,Tomori, Z.,Tonnesen, P.,Varoneckas, G.,Zielinski, J.,Kostelidou, K.; (2007) 'Medico-legal implications of sleep apnoea syndrome: Driving license regulations in Europe'. Sleep Med, . [Details]
Ryan, S, McNicholas, WT, Taylor, CT, ; (2007) 'A critical role for p38 map kinase in NF-kappa B signaling during intermittent hypoxia/reoxygenation'. Biochemical and Biophysical Research Communications, 355 :728-733. [Details]
Ryan, S, Ward, S, Heneghan, C, McNicholas, WT, ; (2007) 'Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome'. Chest, 131 :1100-1107. [Details]
Doherty, LS; Kiely, JL; Deegan, PC; Nolan, G; McCabe, S; Green, AJ; Ennis, S; McNicholas, WT; ; (2007) 'Late-onset central hypoventilation syndrome: a family genetic study'. European Respiratory Journal, 29 (2):312-316. [Details]
Doherty, LS; Kiely, JL; Deegan, PC; Nolan, G; McCabe, S; Green, AJ; Ennis, S; McNicholas, WT; ; (2007) 'Late-onset central hypoventilation syndrome: a family genetic study'. European Respiratory Journal, 29 (2):312-316. [Details]
Doherty, LS,Kiely, JL,Deegan, PC,Nolan, G,McCabe, S,Green, AJ,Ennis, S,McNicholas, WT; (2007) 'Late-onset central hypoventilation syndrome: a family genetic study'. EUR RESPIR J, 29 :312-316. [DOI] [Details]
Ryan, S, Nolan, GM, Hannigan, E, Cunningham, S, Taylor, C, McNicholas, WT, ; (2007) 'Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity'. Thorax, 62 :509-514. [Details]
O'Connor, CM,Lowery, MM,Doherty, LS,McHugh, M,O'Muircheartaigh, C,Cullen, J,Nolan, P,McNicholas, WT,O'Malley, MJ; (2007) 'Improved surface EMG electrode for measuring genioglossus muscle activity'. Respiratory Physiology &Amp; Neurobiology, 159 (NA):55-67. [DOI] [Details]
Ryan, S,Ward, S,Heneghan, C,McNicholas, WT; (2007) 'Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome'. Chest, 131 :1100-1107. [DOI] [Details]
Doherty LS, Kiely JL, Deegan PC, Nolan G, McCabe S, Green AJ, Ennis S, McNicholas WT. ; (2007) 'Late-onset central hypoventilation syndrome: a family genetic study'. EUR RESPIR J, 29 (2):312-316. [Details]
McNicholas WT, Chua CP, Garvey J, Redmond S, Heneghan C, ; (2007) 'Towards automated sleep state estimation using a Holter-oximeter'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, (NA):3998-4001. [DOI] [Details]
O'Connor, C.M., Lowery, M.M., Doherty, L.S., McHugh, M., O'Muircheartaigh, C., Cullen, J., Nolan, P., McNicholas, W.T., and O'Malley M.J.; (2007) 'Improved surface EMG electrode for measuring genioglossus muscle activity'. Respiratory Physiology & Neurobiology, 159 (1):55-67. [Details]
Nolan, G. M.,Doherty, L. S.,Mc Nicholas, W. T.; (2007) 'Auto-adjusting versus fixed positive pressure therapy in mild to moderate obstructive sleep apnoea'. Sleep, 30 (2):189-94. [Details]
Ryan, S, McNicholas, WT & Taylor, CT.; (2007) 'A critical role for p38 MAP kinase in NF-kB signaling during intermittent hypoxia / reoxygenation'. Biochemical and Biophysical Research Communications, 355 (3):728-733. [Details]
O'Connor, C.M., Lowery, M., Doherty, L.S., McHugh, M., O' Muircheartaigh, C., Cullen, J., Nolan, P.J., McNicholas, W.T., and O' Malley, M.J.; (2007) 'Analysis of surface EMG electrode configuration for measuring human genioglossus activity during force varying and fatiguing contractions'. Respiratory Physiology & Neurobiology, . [Details]
Ryan S, McNicholas WT, ; (2006) 'Obstructive sleep apnoea syndrome: translating science to clinical practice'. Respirology (Carlton, Vic.), 2 (NA):136-144. [DOI] [Details]
Garvey, J.,McNicholas, W. T.; (2006) 'Effect of obesity in patients with coronary artery disease'. Lancet, 368 (9548). [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 :824-830. [DOI] [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [Details]
Ryan, S., Taylor, C.T., McNicholas, W.T.; (2006) 'Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, 174 :824-830. [Details]
Ward, S.,Ryan, S.,Mc Nicholas, W. T.,Heneghan, C.; (2006) 'Comparison of baroreflex sensitivity measures for assessing subjects with Obstructive Sleep Apnea'. Conf Proc IEEE Eng Med Biol Soc, 1 :3572-5. [Details]
Ryan, S, Taylor, CT, McNicholas, WT, ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [DOI] [Details]
McNicholas, WT, Ryan, S, ; (2006) 'Obstructive sleep apnoea syndrome: Translating science to clinical practice'. Respirology (Carlton, Vic.), 11 (2):136-144. [Details]
Ryan, S, Taylor, CT, McNicholas, WT, ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 :2660-2667. [DOI] [Details]
Doherty LS, Nolan P, McNicholas WT. ; (2005) 'Effects of topical anesthesia on upper airway resistance during wake-sleep transitions'. Journal of Applied Physiology, 99 :549-555. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 (17):2660-2667. [Details]
Doherty LS, Kiely JL Swan V, McNicholas WT.; (2005) 'Long-term effects of nasal CPAP therapy on cardiovascular outcomes in the sleep apnea syndrome'. Chest, 127 (6):2076-2084. [Details]
Edwards JC, McNicholas WT, Calverley PM, Lee A, ; (2004) 'Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD'. EUR RESPIR J, 6 (NA):825-831. [Details]
Mc Cabe, S; Doherty, L; McNicholas, WT; Green, AJ; Ennis, S; ; (2003) 'A further locus for congenital central hypoventilation syndrome (CCHS)'. American Journal of Human Genetics, 73 (5):561-561. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2003) 'Upper airway muscle paralysis reduces reflex upper airway motor response to negative transmural pressure in rat'. Journal of Applied Physiology, 94 :1307-1316. [DOI] [Details]
Ryan, S; McNicholas, WT; O'Regan, RG; Nolan, P; ; (2003) 'Intralaryngeal neuroanatomy of the recurrent laryngeal nerve of the rabbit'. Journal of Anatomy, 202 (5):421-430. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2003) 'Intralaryngeal neuroanatomy of the recurrent laryngeal nerve of the rabbit'. Journal of Anatomy, 202 :421-430. [Details]
Mc Cabe, S; Doherty, L; McNicholas, WT; Green, AJ; Ennis, S; ; (2003) 'A further locus for congenital central hypoventilation syndrome (CCHS)'. American Journal of Human Genetics, 73 (5):561-561. [Details]
Ryan S., McNicholas, W.T. O'Regan, R.G. and Nolan P.; (2002) 'Effect of upper airway negative pressure and lung inflation on laryngeal motor unit activity in rabbit'. Journal of Applied Physiology, 92 :269-278. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2002) 'Effect of upper airway negative pressure and lung inflation on laryngeal motor unit activity in rabbit'. Journal of Applied Physiology, 92 :269-278. [Details]
Shouldice, R,Heneghan, C,Nolan, P,Nolan, PG,McNicholas, W; (2002) 'Modulating effect of respiration on atrioventricular conduction time assessed using PR interval variation'. Medical &Amp; Biological Engineering &Amp; Computing, 40 :609-617. [Details]
Ryan, S; McNicholas, WT; O'Regan, RG; Nolan, P; ; (2002) 'Effect of upper airway negative pressure and lung inflation on laryngeal motor unit activity in rabbit'. Journal of Applied Physiology, 92 (1):269-278. [Details]
Nolan P, Ryan S, McNicholas WT, O'Regan RG, ; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. The Journal of physiology, Pt 1 (NA):251-265. [Details]
Ryan, S, McNicholas, WT, O'Regan, RG, Nolan, P, ; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. Journal of Physiology-London, 537 (1):251-265. [DOI] [Details]
McNicholas WT, ; (2001) 'Follow-up and outcomes of nasal CPAP therapy in patients with sleep apnea syndrome'. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Universita di Napoli, Secondo ateneo, 6 (NA):535-539. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. The Journal of physiology, 537 :251-265. [Details]
Ryan, S; McNicholas, WT; O'Regan, RG; Nolan, P; ; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. Journal of Physiology-London, 537 (1):251-265. [Details]
Ryan S., McNicholas, W.T., O'Regan, R.G., and Nolan P.; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. Journal of Physiology, 537 :251-265. [Details]
Moloney ED, Kiely JL, McNicholas WT. ; (2001) 'Controlled oxygen therapy and carbon dioxide retention during exacerbations of chronic obstructive pulmonary disease'. The Lancet, 357 (9255):526-528. [Details]
Ryan, S, O'Regan, RG, McNicholas, WT, Nolan, P, ; (2000) 'The effect of upper airway muscle relaxation on the laryngeal afferent response to upper airway negative pressure in the anaesthetised rat'. Journal of Physiology-London, 523 (NA):253-253. [Details]
McNicholas WT, Harbison J, Dodd J, ; (2000) 'Paradoxical vocal cord motion causing stridor after thyroidectomy'. Thorax, 55 (6):533-534. [Details]
McNicholas WT, ; (2000) 'Obstructive sleep apnea syndrome: who should be treated?'. Sleep, (NA):1-90. [Details]
Ryan, S; O'Regan, RG; McNicholas, WT; Nolan, P; ; (2000) 'The effect of upper airway muscle relaxation on the laryngeal afferent response to upper airway negative pressure in the anaesthetised rat'. Journal of Physiology-London, 523 (NA):253-253. [Details]
Breathnach, O.,Donnellan, P.,Collins, D.,McNicholas, W.,Crown, J.; (1999) 'Cytomegalovirus pneumonia in a patient with breast cancer on chemotherapy: Case report and review of the literature'. Annals of Oncology, 10 (4):461-465. Available Online [Details]
Kiely, JL, Donohoe, P, Bresnihan, B, McNicholas, WT, ; (1998) 'Pulmonary fibrosis in polymyositis with the Jo-1 syndrome: an unusual mode of presentation'. Respiratory Medicine, 92 (9):1167-1169. [Details]
Kiely J, Deegan PC, Buckley A, Shiels P, Maurer BM, McNicholas WT. ; (1998) 'Efficacy of nasal continuous positive airway pressure in chronic heart failure: importance of underlying cardiac rhythm'. Thorax, 53 (11):957-962. [Details]
Kiely, JL; Donohoe, P; Bresnihan, B; McNicholas, WT; ; (1998) 'Pulmonary fibrosis in polymyositis with the Jo-1 syndrome: an unusual mode of presentation'. Respiratory Medicine, 92 (9):1167-1169. [Details]
Kiely, JL,Donohoe, P,Bresnihan, B,McNicholas, WT; (1998) 'Pulmonary fibrosis in polymyositis with the Jo-1 syndrome: an unusual mode of presentation'. Respiratory Medicine, 92 :1167-1169. [Details]
Kiely, JL; Donohoe, P; Bresnihan, B; McNicholas, WT; ; (1998) 'Pulmonary fibrosis in polymyositis with the Jo-1 syndrome: an unusual mode of presentation'. Respiratory Medicine, 92 (9):1167-1169. [Details]
McNicholas WT, Costello R, Deegan P, Fitzpatrick M, ; (1997) 'Reversible hypercapnia in chronic obstructive pulmonary disease: a distinct pattern of respiratory failure with a favorable prognosis'. American Journal of Medicine, 3 (NA):239-244. [DOI] [Details]
Costello, R,Deegan, P,Fitzpatrick, M,McNicholas, WT; (1997) 'Reversible hypercapnia in chronic obstructive pulmonary disease: A distinct pattern of respiratory failure with a favorable prognosis'. American Journal of Medicine, 102 :239-244. [Details]
Kiely, JL,McNicholas, WT; (1997) 'Bed partners' assessment of nasal continuous positive airway pressure therapy in obstructive sleep apnea'. Chest, 111 :1261-1265. [Details]
Costello, R; Deegan, P; Fitzpatrick, M; McNicholas, WT; ; (1997) 'Reversible hypercapnia in chronic obstructive pulmonary disease: A distinct pattern of respiratory failure with a favorable prognosis'. American Journal of Medicine, 102 (3):239-244. [Details]
Roe, S, Nolan, P, ORegan, RG, McNicholas, WT, ; (1997) 'The effect of prolonged changes in blood gases and pH on performance and fatigue in the upper airway muscles of the anaesthetized rat'. Journal of Physiology-London, 501P (NA):63-63. [Details]
Kiely, JL, McNicholas, WT, ; (1997) 'Bed partners' assessment of nasal continuous positive airway pressure therapy in obstructive sleep apnea'. Chest, 111 (5):1261-1265. [Details]
Kiely, JL; McNicholas, WT; ; (1997) 'Bed partners' assessment of nasal continuous positive airway pressure therapy in obstructive sleep apnea'. Chest, 111 (5):1261-1265. [Details]
Roe, S; Nolan, P; ORegan, RG; McNicholas, WT; ; (1997) 'The effect of prolonged changes in blood gases and pH on performance and fatigue in the upper airway muscles of the anaesthetized rat'. Journal of Physiology-London, 501P (NA):63-63. [Details]
Deegan, PC,Nolan, P,Carey, M,McNicholas, WT; (1996) 'Effects of positive airway pressure on upper airway dilator muscle activity and ventilatory timing'. Journal of Applied Physiology, 81 :470-479. [Details]
Deegan, PC,McNicholas, WT; (1996) 'Predictive value of clinical features for the obstructive sleep apnoea syndrome'. EUR RESPIR J, 9 :117-124. [Details]
Deegan, PC; Nolan, P; Carey, M; McNicholas, WT; ; (1996) 'Effects of positive airway pressure on upper airway dilator muscle activity and ventilatory timing'. Journal of Applied Physiology, 81 (1):470-479. [Details]
Deegan, PC; McNicholas, WT; ; (1996) 'Predictive value of clinical features for the obstructive sleep apnoea syndrome'. European Respiratory Journal, 9 (1):117-124. [Details]
Donohoe, P,McNicholas, WT; (1996) 'An unusual cause of orthopnoea'. Postgraduate Medical Journal, 72 :439-440. [Details]
Mulloy, E,McNicholas, WT; (1996) 'Ventilation and gas exchange during sleep and exercise in severe COPD'. Chest, 109 :387-394. [Details]
Mulloy, E; McNicholas, WT; ; (1996) 'Ventilation and gas exchange during sleep and exercise in severe COPD'. Chest, 109 (2):387-394. [Details]
Donohoe, P; McNicholas, WT; ; (1996) 'An unusual cause of orthopnoea'. Postgraduate Medical Journal, 72 (849):439-440. [Details]
DEEGAN, PC,MULLOY, E,MCNICHOLAS, WT; (1995) 'TOPICAL OROPHARYNGEAL ANESTHESIA IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA'. American Journal of Respiratory and Critical Care Medicine, 151 :1108-1112. [Details]
DEEGAN, PC; MCNICHOLAS, WT; ; (1995) 'EFFECTS OF (NCPAP) ON CARDIAC-FUNCTION AWAKE AND ASLEEP'. Journal of Sleep Research, 4 (NA):59-63. [Details]
DEEGAN, PC; MCNICHOLAS, WT; ; (1995) 'PATHOPHYSIOLOGY OF OBSTRUCTIVE SLEEP-APNEA'. European Respiratory Journal, 8 (7):1161-1178. [Details]
DEEGAN, PC,MCGLONE, B,MCNICHOLAS, WT; (1995) 'TREATMENT OF ROBIN-SEQUENCE WITH NASAL CPAP'. Journal of Laryngology and Otology, 109 :328-330. [Details]
DEEGAN, PC; MULLOY, E; MCNICHOLAS, WT; ; (1995) 'TOPICAL OROPHARYNGEAL ANESTHESIA IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA'. American Journal of Respiratory and Critical Care Medicine, 151 (4):1108-1112. [Details]
DEEGAN, PC,MCNICHOLAS, WT; (1995) 'EFFECTS OF (NCPAP) ON CARDIAC-FUNCTION AWAKE AND ASLEEP'. Sleep, 4 :59-63. [Details]
DEEGAN, PC; MCGLONE, B; MCNICHOLAS, WT; ; (1995) 'TREATMENT OF ROBIN-SEQUENCE WITH NASAL CPAP'. Journal of Laryngology and Otology, 109 (4):328-330. [Details]
MCNALLY, E; FITZPATRICK, M; BOURKE, S; COSTELLO, R; MCNICHOLAS, WT; ; (1993) 'REVERSIBLE HYPERCAPNIA IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD)'. European Respiratory Journal, 6 (9):1353-1356. [Details]
NOLAN, P; ODONNELL, J; DEEGAN, PC; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'ROLE OF CORTICAL AROUSAL IN THE VENTILATORY RESPONSE TO AIRWAY OCCLUSION DURING SLEEP'. American Review of Respiratory Disease, 147 (4):514-514. [Details]
MULLOY, E,MCNICHOLAS, WT; (1993) 'THEOPHYLLINE IMPROVES GAS-EXCHANGE DURING REST, EXERCISE, AND SLEEP IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE'. American Review of Respiratory Disease, 148 :1030-1036. [Details]
MCNALLY, E,FITZPATRICK, M,BOURKE, S,COSTELLO, R,MCNICHOLAS, WT; (1993) 'REVERSIBLE HYPERCAPNIA IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD)'. EUR RESPIR J, 6 :1353-1356. [Details]
MULLOY, E; MCNICHOLAS, WT; ; (1993) 'THEOPHYLLINE IMPROVES GAS-EXCHANGE DURING REST, EXERCISE, AND SLEEP IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE'. American Review of Respiratory Disease, 148 (4):1030-1036. [Details]
NOLAN, P; BODKIN, S; DEEGAN, PC; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'EFFECTS OF BACKGROUND RESISTIVE LOADING ON UPPER AIRWAY RESPONSES TO EXTERNAL INSPIRATORY RESISTIVE LOADS'. American Review of Respiratory Disease, 147 (4):765-765. [Details]
DEEGAN, PC; NOLAN, P; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'EFFECTS OF CONTINUOUS AND EXPIRATORY POSITIVE AIRWAY PRESSURE ON ALAE-NASI AND GENIOGLOSSUS MUSCLE-ACTIVITY IN AWAKE NORMAL HUMANS'. American Review of Respiratory Disease, 147 (4):767-767. [Details]
MULLOY, E; MCNICHOLAS, WT; ; (1992) 'THEOPHYLLINE IN OBSTRUCTIVE SLEEP-APNEA - A DOUBLE-BLIND EVALUATION'. Chest, 101 (3):753-757. [Details]
MULLOY, E,MCNICHOLAS, WT; (1992) 'THEOPHYLLINE IN OBSTRUCTIVE SLEEP-APNEA - A DOUBLE-BLIND EVALUATION'. Chest, 101 :753-757. [Details]
KEANE, D,MCNICHOLAS, WT; (1992) 'COMPARISON OF NEBULIZED AND SPRAYED TOPICAL ANESTHESIA FOR FIBEROPTIC BRONCHOSCOPY'. EUR RESPIR J, 5 :1123-1125. [Details]
KEANE, D; MCNICHOLAS, WT; ; (1992) 'COMPARISON OF NEBULIZED AND SPRAYED TOPICAL ANESTHESIA FOR FIBEROPTIC BRONCHOSCOPY'. European Respiratory Journal, 5 (9):1123-1125. [Details]
COFFEY, MJ; FITZGERALD, MX; MCNICHOLAS, WT; ; (1991) 'COMPARISON OF OXYGEN DESATURATION DURING SLEEP AND EXERCISE IN PATIENTS WITH CYSTIC-FIBROSIS'. Chest, 100 (3):659-662. [Details]
COFFEY, MJ,FITZGERALD, MX,MCNICHOLAS, WT; (1991) 'COMPARISON OF OXYGEN DESATURATION DURING SLEEP AND EXERCISE IN PATIENTS WITH CYSTIC-FIBROSIS'. Chest, 100 :659-662. [Details]
CHADWICK, GA,CROWLEY, P,FITZGERALD, MX,OREGAN, RG,MCNICHOLAS, WT; (1991) 'OBSTRUCTIVE SLEEP-APNEA FOLLOWING TOPICAL OROPHARYNGEAL ANESTHESIA IN LOUD SNORERS'. American Review of Respiratory Disease, 143 :810-813. [Details]
CHADWICK, GA; CROWLEY, P; FITZGERALD, MX; OREGAN, RG; MCNICHOLAS, WT; ; (1991) 'OBSTRUCTIVE SLEEP-APNEA FOLLOWING TOPICAL OROPHARYNGEAL ANESTHESIA IN LOUD SNORERS'. American Review of Respiratory Disease, 143 (4):810-813. [Details]
McNicholas WT, Coffey M, McDonnell T, O'Regan R, FitzGerald MX. ; (1987) 'Upper airway obstruction during sleep in normal subjects after selective topical anesthesia'. American Review of Respiratory Disease, 135 (6):1316-1319. [Details]
Goldstein RS, Ramcharan V, Bowes G, McNicholas WT, Bradley D, Phillipson EA.; (1984) 'Effects of supplemental oxygen on gas exchange during sleep in patients with severe obstructive lung disease'. New England Journal of Medicine, 310 (7):425-429. [Details]
 

Conference Publications

1. Chua C.P., McSharry D.G., McNicholas W.T. and Lowery M.M. ; (2009) Towards a Genioglossus Surface EMG Model of Obstructive Sleep Apnea IEEE Engineering in Medicine and Biology Conference [Details]
5. McSharry D.G., McNicholas C., Lowery M.M., O'Connor C., Langran S., O'Sullivan M. and McNicholas W.T. ; (2009) Measurement of genioglossus fatigue in obstructive sleep apnoea syndrome patients and control American Thoracic Society International Conference [Details]
McSharry D., Lowery M., O'Sullivan M., O'Connor C., Langran S. and McNicholas W. ; (2008) Validation of a novel surface electrode array to measure genioglossus fatigability  European Respiratory Society Annual Congress, Berlin, Oct. 2008 [Details]
Sheridan, E., Heneghan, C., OMalley, M.J., Nolan, P., McNicholas, W, Cullen, J. P., Nolan, P.G.; (2001) Characterization of autonomic nervous influences on PR and RR intervals in the electrocardiogram Proceedings of the 23rd Annual International Conference of the IEEE Eng. Med. Biol. Soc. Istanbul, Turkey, vol. 1, October, 2001 Istanbul, Turkey, , pp.540-543 [Details]
Cullen, J., Lowery, M., McNicholas, W., Nolan, P., OMalley, M. J. and OMuircheartaigh, C.,; (2001) Optimisation of electrode design to detect myoelectric manifestations of fatigue in human genioglossus muscle XXXIV International Congress of Physiological Sciences, Christchurch, New Zealand, August 2001 Christchurch, New Zealand, [Details]
Heneghan, C., Shouldice, R., Nolan, P., Sheridan, E, OMalley, M. J., Nolan, P. G., Cullen, J. and McNicholas, W.; (2001) Independent autonomic modulation of the sinoatrial and atrioventricular nodes assessed through RR and PR interval variation Proceedings of Computers in Cardiology, Rotterdam, Sept. 2001 Rotterdam, , pp.205-208 [Details]
McHugh, M., Cullen, J., McNicholas, W., Nolan, P., and OMalley, M. J.; (1999) Muscle force and EMG measurement in an upper airway muscle Proceedings of the XVIIth Congress of the International Society of Biomechanics, p. 883, Calgary, Canada, August, 1999 Calgary, Canada, [Details]
   

Editorial

McNicholas, WT,Levy, P; (2011) Portable monitoring in sleep apnoea: the way forward?. Editorial [DOI] [Details]
T McNicholas, W; (2006) Optimizing continuous positive airway pressure therapy for obstructive sleep apnea syndrome. Editorial [Details]
Riha, RL,McNicholas, WT; (2009) The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

Research Projects

Sponsor : AstraZeneca Pharmaceuticals Ltd., Ireland
Title : Obesity and Obstructive Sleep Apnoea: Cardiovascular, Metabolic and Inflammatory Association
Start Date / End Date : 01-JUL-09 / 30-JUN-11
Sponsor : Health Research Board (HRB)
Title : Role of nitric oxide in modulating inflammatory pathways during intermittent hypoxia
Start Date / End Date : 01-JUL-09 / 30-JUN-12