UCD Research: Office of Registrar

People

Professor Mark S Rogers BA PhD

Contact Details

Title	Vice-President For Academic Affairs
Address	Office of Registrar Tierney Building Belfield Dublin 4
Telephone:	Ext. 2197
Email:	ei.dcu@sregor.kram

Biography:

Prof. Rogers undertook a degree in Genetics in University of Dublin, Trinity College graduating with a First class honours in 1983. Moving to Glasgow, he undertook a PhD on the genetics of transposition of the bacterial transposon Tn7 under the supervision of Prof. David Sherratt FRS and was awarded a Ph.D. in Genetics from the University of Glasgow in 1986.

With a Fellowship from EMBO and subsequently, the John Douglas French Foundation for Alzheimer's Research, Prof. Rogers undertook research in the Laboratory of Nobel Laureate Prof. Stanley Prusiner in Prion Diseases before returning to Ireland in 1991 to take up a lectureship in University College Dublin.

Prof. Rogers has continued his research in the field of scrapie in sheep and BSE in cattle and has published many research papers that are highly cited in prestigious journals. He has also sucessfully licenced immunodiagnostic technologies that have been employed in BSE diagnosis and resulted in over ¿2 million in royalties accruing to the University.

Prof. Rogers was Dean of Science between 2005 and 2011. During this time, he led substantial changes in the Science Programme resulting in a consolidation of entry routes and the introduction of a new programme structure in 2010. In 2011 Prof. Rogers became the Acting Registrar, Deputy President and Vice President for Academic Affairs.

Research Interests

Our research group is interested in the neurodegenerative diseases caused by a novel group of infectious agents called prions. The prion is a misfiled form of a normal host protein termed PrP. Diseases caused by prions include Creutzfeldt-Jacob disease (CJD) in humans, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. The human diseases may be inherited or caused by infection. The economic consequences of this family of disease are of particular significance in Ireland where a large proportion of the cattle production is exported. In addition, the health consequences of the human prion diseases extend beyond the affected individuals but include risks to the blood supply and to contamination of pharmaceuticals and other products derived from animal sources.

Research into the genetics, cell biology and transmission of prion diseases and their diagnosis. Additional interests include molecular epidemiology of animal diseases and the development of improved methods for antibody development.

Peer Reviewed Journals

Fischer, M., Appelhans, D., Schwarz, S., Klajnert, B., Bryszewska, M., Voit, B. and Rogers, M.; (2010) 'Influence of surface functionality of poly(propylene imine) dendrimers on protease resistance and propagation of the scrapie prion protein'. Biomacromolecules, 11 (5):1314-1325.

[DOI] [Details]

Forde, N., Rogers, M., Canty, M. J., Lonergan, P., Smith, G. W., Coussens, P. M., Ireland, J. J., Evans, A. C. O., ; (2008) 'Association of the prion protein and its expression with ovarian follicle development in cattle'. Molecular Reproduction and Development, 75 (2):243-249. [DOI] [Details]

Bandyopadhyay, S., Ni, J., Ruggiero, A., Walshe, K., Rogers, M.S., Naibedya Chattopadhyay, N.,Marcie A. Glicksman, M.A. and Rogers J.T; (2006) 'A High-Throughput Drug Screen Targeted to the 5'Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA'. Journal of Biomolecular Screening, 11 (5):469-480.

[DOI] [Details]

Castilla, J., Gutiérrez-Adán, A., Brun, A., Doyle, D., Pintado, B., Ramírez, M. A., Salguero, F. J., Parra, B., San Segundo, F. D., Sánchez-Vizcaíno, J. M., Rogers, M., and Torres, J.M.; (2004) 'Detection of subclinical BSE infection in transgenic mice expressing procine PrPC'. JOURNAL OF NEUROSCIENCE, 24 (21):5063-5069.

[DOI] [Details]

Murphy, C., Breen, C., Rogers, M., and Giese, M.; (2001) 'Interferon gamma and prostaglandin in BSE-infected cattle'. CYTOKINE, 13 (3):169-173.

[DOI] [Details]

Rogers M., D. Doyle and M. Giese; (2000) 'Prions: Strategies for control of BSE and scrapie'. IRISH JOURNAL OF AGRICULTURE AND FOOD RESEARCH, 39 :229-234. [Details]
OBrien, R., Danilowicz, B.S., Bailey, L., Flynn, O., Costello, E., O'Grady, D., and Rogers, M.; (2000) 'Characterization of the mycobacterium bovis restriction fragment length polymorphism DNA probe pUCD and performance comparison with standard methods'. JOURNAL OF CLINICAL MICROBIOLOGY, 38 (9):3362-3369. [Details]
Loftus, B., Monks, E., Hanlon, J., Weavers, E., and Rogers, M.; (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. IRISH VETERINARY JOURNAL, 52 :81-85. [Details]
McMahon, R. A., Hurley, P. T., Egan, T. M., Nelson, A., Rogers, M., and Martin, F. ; (1999) 'Genomic structure of the Human P2x(2) receptor: alternative splicing generates multiple transcripts'. BRITISH JOURNAL OF PHARMACOLOGY, 126 . [Details]
Costello E,D. O'Grady , O. Flynn, R. O'Brien, M. Rogers, F. Quigley, J. Egan, J. Griffin; (1999) 'Study of restriction fragment length polymorphism analysis and spoligotyping for epidemiological investigation of Mycobacterium bovis infection'. JOURNAL OF CLINICAL MICROBIOLOGY, 37 (10):3217-3222. [Details]
Rogers M.; (1998) 'Strategies for the control of BSE and scrapie'. JOURNAL OF FOOD SAFETY, 18 :355-362. [Details]
Page DT, N OConnor, P Masokwane, F Martin , M Rogers, K OBoyle; (1998) 'The development of novel recombinant systems for analysing intracellular neurotransmitter receptor interactions'. IRISH JOURNAL OF MEDICAL SCIENCE, 167 . [Details]
Borchelt D, M. Rogers, N Stahl , G Telling, SB. Prusiner; (1993) 'Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor'. GLYCOBIOLOGY, 3 (4):319-329. [Details]
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Book Chapters

Doyle, D., O'Brien, M., Harmey, J., and Rogers, M.; (1998) 'Identification of differentially expressed genes in prion infection by differential display' In: Proceedings RIA Symposia on Zoonoses. Ireland: Royal Irish Academy. [Details]

Rogers, M. and S. B. Prusiner; (1992) 'Human and Animal Prion Diseases' In: J. R. M. Copeland (eds). Alzheimers Disease. Potential Therapeutic Strategies. London: IBC. [Details]

Books

Sheridan J.J., M OKeefe and M Rogers,; (1998) Food safety The implications of change from producerism to consumerism. : Trumbull. [Details]

Honours and Awards

Year: 2004.
Title: NOVAUCD Innovation Award

Committees

Committee : Scientific Committee for Animal Health Welfare 2002-present

Committee : Food Safety Authority Scientific Sub-committee on TSE 2005-present

Employment

Employer: University College Dublin
Position: Dean of Science 2007-present

Employer: University College Dublin
Position: Professor 2004-present

Employer: University College Dublin
Position: Head of Department 2000-2003

Education

Year 1986 Institution: University of Glasgow, Scotland
Qualification: PhD Subject:

Other Activities

2004-2006 University Biosafety Officer.

Internal Collaborators

External Collaborators

Dr. Gary Jones, Yeast Genetics Laboratory, Dept. of Biology, Maynooth University; HRB funded projects on the effects of mutant Hsp70 species on mammalian prion propagation.

Dr. Neil Rowan, Athlone Institute of Technology: Inactivation of prions using pulsed plasma discharge.

Dr. Dietmar Appelhans, Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden (Germany); Dendrimers as therapeutic agents for Prion diseases

Dr. Barbara Klajnert, Department of General Biophysics, University of Lodz, 12/16 Banacha Street, 90-237 Lodz (Poland); Dendrimers as therapeutic agents for Prion diseases

Teaching Philosophy

Since 1992 I have contributed to the teaching in Zoology, Genetics and Cell and Molecular Biology degree programmes. My contributions have covered all levels of the degree in the areas of Genetics, Immunology, Cell Biology, Endocrinology and my specialist research field of Prion Diseases.