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Researchers at UCD

researcher

Mark S Rogers

Vice-President For Academic Affairs

Office of Registrar
Tierney Building
Belfield
Dublin 4

Tel: +353 1 7162197
Email: registrar.vpacademic@ucd.ie

Biography

Professor Mark Rogers graduated from Trinity College in 1983 with a first class honours degree in Genetics and obtained a PhD in Genetics from the University of Glasgow in 1986. With a Fellowship from EMBO and, subsequently, the John Douglas French Foundation for Alzheimer's Research, he undertook research in the Laboratory of Nobel Laureate Professor Stanley Prusiner in Prion Diseases before returning to Ireland in 1991 to take up a lectureship at University College Dublin.

His research is in the field of scrapie in sheep and BSE in cattle, and he has published many research papers that are highly cited in prestigious journals. He has led several large EU research consortiums in Prion research and successfully licensed immunodiagnostic technologies that have been employed in BSE diagnosis, resulting in over ¿2 million in royalties accruing to the University.

Recognising the importance of research in creating knowledge and innovation, Professor Rogers has consistently used his research to inform his teaching practice. In 2006 he was appointed Dean of Science. During his time as Dean significant changes were made to the Science programme, including the revision and enhancement of the structure and its delivery to students, and the introduction of new assessment practices.

Professor Rogers strongly promotes a student centred and student-led approach to education that encourages the student in independent learning. He is committed to teaching, and has been instrumental in introducing new approaches to teaching first year students in order to encourage active learning and engagement with their subject from the start of their University life.

Professor Rogers took up the post of Acting Registrar and Deputy President of UCD in August 2011.

Professional

Honours and Awards

Year: 2004.
Title: NOVAUCD Innovation Award
                         

Publications

Books

Sheridan J.J., M OKeefe and M Rogers,; (1998) Food safety The implications of change from producerism to consumerism. : Trumbull. [Details]

Book Chapters

Doyle, D., O'Brien, M., Harmey, J., and Rogers, M.; (1998) 'Identification of differentially expressed genes in prion infection by differential display' In: Proceedings RIA Symposia on Zoonoses. Ireland: Royal Irish Academy. [Details]
Rogers, M. and S. B. Prusiner; (1992) 'Human and Animal Prion Diseases' In: J. R. M. Copeland (eds). Alzheimers Disease. Potential Therapeutic Strategies. London: IBC. [Details]
Rogers, M., Taraboulos, A., SCOTT, M., Borchelt, D., Serban, D., Gyuris, T., Prusiner, S. B.; (1992) 'Modification and expression of prion proteins in cultured cells' In: Prusiner, S. B., Collinge, J., Powell, J., Anderton, B (eds). Prion Diseases of Humans and Animals. London: Ellis Horwood. [Details]
 

Peer Reviewed Journals

McCarthy JM, Rasines Moreno B, Filippini D, Komber H, Maly M, Cernescu M, Brutschy B, Appelhans D, Rogers MS (2013) 'Influence of Surface Groups on Poly(propylene imine) Dendrimers Antiprion Activity'. Biomacromolecules, 14 (1):27-37. [DOI] Link to full text [Details]
McCarthy J.M., Franke M, Resenberger U.K., Waldron S, Simpson J.C., Tatzelt J, Appelhans D and Rogers M.S. (2013) 'Anti-prion drug mPPIg5 inhibits PrPC conversion to PrPSc'. PLoS ONE, . Link to full text [Details]
McCarthy JM, Rasines B, Appelhans D, Rogers M (2012) 'Differentiating prion strains using dendrimers'. Advanced healthcare materials, 1 (6):768-772. [DOI] Link to full text [Details]
Fischer, M., Appelhans, D., Schwarz, S., Klajnert, B., Bryszewska, M., Voit, B. and Rogers, M.; (2010) 'Influence of surface functionality of poly(propylene imine) dendrimers on protease resistance and propagation of the scrapie prion protein'. Biomacromolecules, 11 (5):1314-1325. Available Online [DOI] Link to full text [Details]
Forde, N., Rogers, M., Canty, M. J., Lonergan, P., Smith, G. W., Coussens, P. M., Ireland, J. J., Evans, A. C. O., ; (2008) 'Association of the prion protein and its expression with ovarian follicle development in cattle'. Molecular Reproduction and Development, 75 (2):243-249. [DOI] [Details]
Espinosa, JC,Morales, M,Castilla, J,Rogers, M,Torres, JM; (2007) 'Progression of prion infectivity in asymptomatic cattle after oral bovine spongiform encephalopathy challenge'. Journal of General Virology, 88 :1379-1383. [DOI] [Details]
Bandyopadhyay, S., Ni, J., Ruggiero, A., Walshe, K., Rogers, M.S., Naibedya Chattopadhyay, N.,Marcie A. Glicksman, M.A. and Rogers J.T; (2006) 'A High-Throughput Drug Screen Targeted to the 5'Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA'. Journal of Biomolecular Screening, 11 (5):469-480. Available Online [DOI] [Details]
Pichon, B,Rogers, M,Egan, D,Gray, J; (2005) 'Blood-meal analysis for the identification of reservoir hosts of tick-borne pathogens in Ireland'. Vector Borne Zoonotic Diseases, 5 :172-180. [Details]
Castilla, J., Gutiérrez-Adán, A., Brun, A., Doyle, D., Pintado, B., Ramírez, M. A., Salguero, F. J., Parra, B., San Segundo, F. D., Sánchez-Vizcaíno, J. M., Rogers, M., and Torres, J.M.; (2004) 'Detection of subclinical BSE infection in transgenic mice expressing procine PrPC'. JOURNAL OF NEUROSCIENCE, 24 (21):5063-5069. Available Online [DOI] [Details]
Pichon, B; Egan, D; Rogers, M; Gray, JS; ; (2004) 'Reservoir host identification by analysis of host-seeking ticks'. International Journal of Medical Microbiology, 293 (NA):118-118. [Details]
Pichon, B., Egan, D., Rogers, M. and Gray, J. S.; (2003) 'Detection and identification of pathogens and host DNA in unfed host-seeking Ixodes ricinus L. (Acari:Ixodidae)'. Journal of Medical Entomology, 40 :723-731. [Details]
Castilla, J,Adan, AG,Brun, A,Pintado, B,Ramirez, MA,Parra, B,Doyle, D,Rogers, M,Salguero, FJ,Sanchez, C,Sanchez-Vizcaino, JM,Torres, JM; (2003) 'Early detection of PRPres in BSE-infected bovine PrP transgenic mice'. Archives of Virology, 148 :677-691. [DOI] [Details]
Hanlon, J; Monks, E; Hughes, C; Weavers, E; Rogers, M; ; (2002) 'Metallothionein in bovine spongiform encephalopathy'. Journal of Comparative Pathology, 127 (4):280-289. [Details]
Murphy, C,Breen, C,Rogers, M,Giese, M; (2001) 'Interferon gamma and prostaglandin in BSE-infected cattle'. Cytokine, 13 :169-173. [DOI] [Details]
Cameron, H,O'Brien, R,Murray, A,Cryan, B,Hone, R,Rogers, M; (2001) 'Evaluation of the Mycobacterium bovis restriction fragment length polymorphism probe pUCD, in combination with the direct repeat probe, for molecular typing of Mycobacterium tuberculosis strains in Ireland'. Journal of Clinical Microbiology, 39 :4404-4406. [Details]
Rogers M., D. Doyle and M. Giese; (2000) 'Prions: Strategies for control of BSE and scrapie'. IRISH JOURNAL OF AGRICULTURE AND FOOD RESEARCH, 39 :229-234. [Details]
O'Brien, R,Danilowicz, BS,Bailey, L,Flynn, O,Costello, E,O'Grady, D,Rogers, M; (2000) 'Characterization of the Mycobacterium bovis restriction fragment length polymorphism DNA probe pUCD and performance comparison with standard methods'. Journal of Clinical Microbiology, 38 :3362-3369. [Details]
O'Brien, R,Flynn, O,Costello, E,O'Grady, D,Rogers, M; (2000) 'Identification of a novel DNA probe for strain typing Mycobacterium bovis by restriction fragment length polymorphism analysis'. Journal of Clinical Microbiology, 38 :1723-1730. [Details]
Loftus, B., Monks, E., Hanlon, J., Weavers, E., and Rogers, M.; (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. IRISH VETERINARY JOURNAL, 52 :81-85. [Details]
McMahon, R. A., Hurley, P. T., Egan, T. M., Nelson, A., Rogers, M., and Martin, F. ; (1999) 'Genomic structure of the Human P2x(2) receptor: alternative splicing generates multiple transcripts'. BRITISH JOURNAL OF PHARMACOLOGY, 126 . [Details]
Costello E,D. O'Grady , O. Flynn, R. O'Brien, M. Rogers, F. Quigley, J. Egan, J. Griffin; (1999) 'Study of restriction fragment length polymorphism analysis and spoligotyping for epidemiological investigation of Mycobacterium bovis infection'. JOURNAL OF CLINICAL MICROBIOLOGY, 37 (10):3217-3222. [Details]
McMahon, RA; Hurley, PT; Egan, TM; Nelson, A; Rogers, M; Martin, F; ; (1999) 'Genomic structure of the human P2X(2) receptor: Alternative splicing generates multiple transcripts'. British Journal of Pharmacology, 126 (NA):14-14. [Details]
Loftus, B,Monks, E,Hanlon, J,Weavers, E,Rogers, M; (1999) 'Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland'. Irish Veterinary Journal, 52 :81-85. [Details]
Costello, E,O'Grady, D,Flynn, O,O'Brien, R,Rogers, M,Quigley, F,Egan, J,Griffin, J; (1999) 'Study of restriction fragment length polymorphism analysis and spoligotyping for epidemiological investigation of Mycobacterium bovis infection'. Journal of Clinical Microbiology, 37 :3217-3222. [Details]
Page, DT; O'Conner, N; Rogers, M; Martin, F; O'Boyle, KM; ; (1999) 'Evidence for interactions between D-1 and D-2s dopamine receptors co-expressed in BHK cells'. British Journal of Pharmacology, 126 (NA):14-14. [Details]
Rogers M.; (1998) 'Strategies for the control of BSE and scrapie'. JOURNAL OF FOOD SAFETY, 18 :355-362. [Details]
Guinan, E; Doyle, D; Rogers, M; ; (1998) 'Clathrin-coated vesicles and detergent-resistant rafts in prion biology - Commentary'. Bulletin De L Institut Pasteur, 96 (3):210-212. [Details]
O'Connor, N; Page, D; Martin, F; Rogers, M; O'Boyle, KM; ; (1998) 'Actions of dopamine and A68930 on BHK cells co-transfected with D-1 and D-2 receptors'. British Journal of Pharmacology, 125 (NA):42-42. [Details]
Page DT, N OConnor, P Masokwane, F Martin , M Rogers, K OBoyle; (1998) 'The development of novel recombinant systems for analysing intracellular neurotransmitter receptor interactions'. IRISH JOURNAL OF MEDICAL SCIENCE, 167 . [Details]
Hurley, PT; McMahon, RA; Fanning, P; O'Boyle, KM; Rogers, M; Martin, F; ; (1998) 'Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells'. British Journal of Pharmacology, 124 (6):1238-1244. [Details]
Clostello, E; O'Grady, D; O'Brien, R; Flynn, O; Rogers, M; Quigley, F; Egan, J; Griffin, J; ; (1998) 'Strain typing of Mycobacterium bovis isolates'. Irish Veterinary Journal, 51 (3):133-133. [Details]
Doyle, D; Rogers, M; ; (1998) 'A new mechanism broadening the role of prion proteins in neurodegeneration'. Trends in Genetics, 14 (5):171-173. [Details]
Doyle D, M OBrien, J Harmey, M Rogers; (1997) 'Identification of differentially expressed genes in prion infection by differential display'. PROCEEDINGS ROYAL IRISH ACADEMY, SECTION A, :1-13. [Details]
Loftus, B; Rogers, M; ; (1997) 'Characterization of a prion protein (PrP) gene from rabbit; A species with apparent resistance to infection by prions'. Gene, 184 (2):215-219. [Details]
DeArmond, S. J., Sánchez, H., Yehiely, F., Qiu, Y., Ninchak-Casey, A., Daggett, V., Camerino, A. P., Cayetano, J., Rogers, M., Groth, D., Torchia, M., Tremblay, P., Scott, M. R., Cohen, F. E., Prusiner, S. B.; (1997) 'Selective neuronal targeting in prion disease'. Neuron, 19 :1337-1348. [Details]
Flavin N, A. Heriz , V. Monteagudo , S. Ennis , W.Barendse , F.Martin, V Arruga , M Rogers; (1996) 'Cloning of the bovine activin receptor type II gene (ACVR2) and mapping to chromosome 2 (BTA2)'. CELL GENETICS AND CYTOGENITICS, 75 :25-29. [Details]
Monteagudo, L; Heriz, A; Flavin, N; Ennis, S; Rogers, M; Arruga, MV; ; (1996) 'FISH mapping of activin receptor type IIA (ActRIIA) to bovine chromosome 2q2.2->q2.4'. Cytogenetics and Cell Genetics, 74 (3):237-237. [Details]
Flavin, N; Monteagudo, L; Heriz, A; Tejedor, MT; Ennis, S; Rogers, M; Arruga, MV; ; (1996) 'DNA sequence and synteny and linkage mapping of bovine activin receptor type IIA (ActRIIA)'. Cytogenetics and Cell Genetics, 74 (3):231-232. [Details]
Monteagudo LV, Heriz A, Flavin N, Rogers M, Ennis S, Arruga MV. ; (1996) 'Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4)'. Mammalian Genome, 7 (11). [Details]
Hughes, MS; Neill, SD; Rogers, MS; ; (1996) 'Vaccination of the badger (Meles meles) against Mycobacterium bovis'. Veterinary Microbiology, 51 (3-4):363-379. [Details]
Harmey J, D Doyle, V Brown, MS. Rogers; (1995) 'The cellular prion protein, PrPC, is associated with caveolae in mouse neuroblastoma (N2a) cells'. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 210 :753-759. [Details]
Rogers M, Flavin N, Ennis S, Condon J, ; (1995) 'UCD001: a bovine cosmid containing a polymorphic dinucleotide repeat maps to chromosome 4'. Animal Genetics, 26 (5):372-373. [Details]
Borchelt D, M. Rogers, N Stahl , G Telling, SB. Prusiner; (1993) 'Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor'. GLYCOBIOLOGY, 3 (4):319-329. Available Online [Details]
Rogers, M., Yehiely, F., SCOTT, M., Prusiner, S. B.; (1993) 'Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells'. Proceedings of the National Academy of Sciences of the, 90 :3182-3186. [Details]
Rogers, M., Serban, D., Gyuris, T., SCOTT, M., Torchia, T., Prusiner, S. B.; (1991) 'Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system'. Journal of Immunology, 147 :3568-3574. [Details]
Taraboulos, A., Rogers, M., Borchelt, D.R., McKinley, M.P., SCOTT, M., Serban, D., Prusiner, S.B.; (1990) 'Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation'. Proceedings of the National Academy of Sciences of the, 87 :8262-8266. [Details]
Rogers, M., Taraboulos, A., SCOTT, M., Groth, D., Prusiner, S.B.; (1990) 'Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites'. Glycobiology, 1 :101-109. [Details]
Rogers, M., Ekaterinaki, N., Nimmo, E., and Sherratt, D.; (1986) 'Analysis of Tn7 transposition'. MOLECULAR & GENERAL GENETICS, 205 (3):550-556. [Details]
Sharp P, Rogers M, McConnell DJ; (1984) 'Selection pressures on codon usage in the complete genome of bacteriophage T7'. JOURNAL OF MOLECULAR EVOLUTION, 21 (2):150-160. [Details]

Other Journals

Rogers M. ; (1996) 'Prions; BSE and scrapie research in Ireland' Technology Ireland 28 :33-35. [Details]

Conference Publications

Forde, N., Canty, M., Zielak, A., Lonergan, P., Rogers, M., Evans, A.C.O.; (2005) PrPc expression in bovine ovarian follicle development Fertility 2005, Biennial Joint Meeting of the UK Fertility Societies [Details]
Forde, N., Canty, M.J., Zielak, A.E., Lonergan, P., Rogers, M., Evans, A.C.O.; (2005) Increased expression of PrPc in the theca cells of dominant compared to subordinate ovarian follicles in cattle Irish Fertility Society Inaugral AGM  and First Scientific Meeting Meeting [Details]
Greenway M., Alexander M., Ennis S., Traynor B., Rogers M., O¿Hici B., Lynch C., O¿Toole O., Corr B., Frost E., Green A., Hardiman O. ; (2004) Single nucleotide polymorphisms in Amyotrophic Lateral Sclerosis Proceedings of the Beaumont Hospital Scientific Meeting [Details]
Pichon, B., Egan, D., Rogers, M. and Gray, J. S. ; (2004) Reservoir host identification by analysis of host-seeking ticks Proceedings of XIIth International Potsdam Conference on Tick-borne Diseases, International Journal of Medical Microbiology [Details]
Hurley, P; McMahon, R; Fanning, P; O'Boyle, KM; Voigt, M; Rogers, M; Martin, F; ; (1997) BRITISH JOURNAL OF PHARMACOLOGY Direct evidence that ligand activation of the human 5-HT5A receptor results in coupling to G-proteins in HEK-293 cells [Details]
Flavin-N; Monteagudo-L; Heriz-A; Ennis-S; Rogers-M; Arruga-M-V; (1996) DNA sequence and synteny and linkage mapping of bovine activin receptor type IIA (ActRIIA) Archivos de Zootecnia [Details]
Ennis, S. and Flavin, N. and Rogers, M. ; (1996) Report of the activities of the UCD group in the BovMap project 5th BovMap meeting Tours [Details]
Flavin-N; Monteagudo-L; Heriz-A; Ennis-S; Rogers-M; Arruga-M-V; (1996) Fish mapping of activin receptor type IIA (ActRIIA) to bovine chromosome 2 (2q2.2-2.4) Archivos de Zootecnia [Details]
Ennis, S. and Flavin, N. and Rogers, M; (1995) Approaches towards integrating the genetic and Physical Bovine maps 4th BovMap meeting Dublin [Details]
   

Editorial

Guinan, E,Doyle, D,Rogers, M; (1998) Clathrin-coated vesicles and detergent-resistant rafts in prion biology - Commentary. Editorial [Details]
Doyle, D,Rogers, M; (1998) A new mechanism broadening the role of prion proteins in neurodegeneration. Editorial [Details]
       

Reports

O'Brien R. and M. Rogers; (1998) Final report on genotyping of M.bovis isolates by REA/RFLP analysis. Reports [Details]
Hughes S. and M. Rogers; (1994) The feasibility of developing a vaccine against tuberculosis for use in the badger (Meles meles). Reports [Details]
OBrien R. and M Rogers; (1994) Interim report on genotyping of M.bovis isolates by REA/RFLP analysis. Reports [Details]
                                                                         

Research

Research Interests

Our research group is interested in the neurodegenerative diseases caused by a novel group of infectious agents called prions. The prion is a misfiled form of a normal host protein termed PrP. Diseases caused by prions include Creutzfeldt-Jacob disease (CJD) in humans, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. The human diseases may be inherited or caused by infection. The economic consequences of this family of disease are of particular significance in Ireland where a large proportion of the cattle production is exported. In addition, the health consequences of the human prion diseases extend beyond the affected individuals but include risks to the blood supply and to contamination of pharmaceuticals and other products derived from animal sources.


Research into the genetics, cell biology and transmission of prion diseases and their diagnosis. Additional interests include molecular epidemiology of animal diseases and the development of improved methods for antibody development.

     

Collaborators

Internal Collaborators

External Collaborators

Dr. Dietmar Appelhans, Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden (Germany); Dendrimers as probes to characterise Prion diseases

Dr. Barbara Klajnert, Department of General Biophysics, University of Lodz, 12/16 Banacha Street, 90-237 Lodz (Poland); Dendrimers as therapeutic agents for Prion diseases