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Researchers at UCD

Catherine Phillips

Research Fellow

School Of Public Hlth, Phys & Sports Sci

Tel:
Email: catherine.phillips@ucd.ie

Biography

Following a BSc. (Hons) in Biochemistry from University College Dublin and a Ph.D entitled Studies of Postprandial Lipoprotein Metabolism in Diabetes, from Trinity College Dublin, I continued my postdoctoral research in the Royal College of Surgeons of Ireland investigating aspects of postprandial lipoprotein metabolism in Type 2 diabetes and insulin resistance. I then joined the Nutrigenomics Research Group, Trinity College Dublin (and later at University College Dublin) to work on two EU 6th Framework initiatives - NuGO (European Nutrigenomics Organisation) and LIPGENE (Diet, genomics and the metabolic syndrome: an integrated nutrition, agro-food, social and economic analysis). NuGO is a Network of Excellence, linking genomics, nutrition and health research (www.nugo.org). The LIPGENE project (www.ucd.ie/lipgene) involved a prospective genetic study and a human dietary intervention trial to test the interaction between dietary fat exposure and genetic risk of the metabolic syndrome. Within LIPGENE I coordinated the prospective case-control genetic study in collaboration with INSERM U476 & U557 (Marseille and Paris) which investigated genetic associations with metabolic syndrome and its phenotypes, and whether interaction with dietary fatty acid composition modulated these relationships. 

I joined the HRB Centre for Diet and Health Research, University College Cork in 2011 as a Principal Investigator on the Cork and Kerry Study/Mitchelstown cohort. This cross-sectional study of middle-aged men and women is examining the effects of dietary exposures and lifestyle factors on obesity and the metabolic syndrome - a very common, multi-component, condition characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension that is associated with increased risk of type 2 diabetes mellitus, cardiovascular disease and atherosclerosis. This study represents a valuable resource to additionally test a range of other hypotheses relevant to diet-related disease. Current research interests include obesity, diabetes and cardiometabolic risk prediction, determinants of and associations between inflammatory biomarkers, lipoprotein particle profiles and cardiometabolic risk, and examination of the metabolically healthy obese phenotype and its determinants. Since September 2014 I hold a joint appointment with the School of Public Health, Physiotherapy and Sports Science, University College Dublin for the second phase of the HRB Centre during which my research interests will additionally focus on childhood, maternal, morbid adult and intergenerational obesity. Since Jan 2017 I am lead PI and coordinator of the ALPHABET project (Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health). This project aims to improve our understanding of nutritional and epigenetic biomarkers of offspring health, with a view to refining dietary exposure measures and to aid development of more effective evidence-based public health strategies with an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations. The ALPHABET consortium includes University College Dublin, Ireland; University of Bristol, UK; University of Southampton, UK; INSERM UMR 1153, France; Erasmus MC, University Medical Center Rotterdam, Netherlands; Nofer Institute of Occupational Medicine, Poland and University of South Carolina, US.

Professional

Honours and Awards

Year: 2001.
Title: Finalist, Young Investigator Award, European Atherosclerosis Society.
Year: 2000.
Title: European Foundation for the Study of Diabetes and Merck Travel Fellowship for Young Scientists.
Year: 1998.
Title: Student Travel Fellowship, European Association for the Study of Diabetes.
Year: 1998.
Title: Finalist, RCSI Sheppard Trust Prize.
Year: 1999.
Title: Irish Endocrine Society Travel Fellowship.

Associations

Association: Nutrition Society, Function/Role: Member
Association: European Nutrigenomics Organisation, Function/Role: Member
Association: European Atherosclerosis Society, Function/Role: Member
     

Conference Contributions

Phillips, C.; (1998) British Diabetic Association: Edinburgh 1998. [Oral Presentation], British Diabetic Association, Edinburgh , 01-JAN-98.
Phillips, C.; (1998) Joint Meeting of the EASD Lipids Study Group: Valencia. 1998. [Oral Presentation], Joint Meeting of the EASD Lipids Study Group, Valencia , 01-JAN-98.
Phillips, C.; (1998) Royal College of Surgeons in Ireland Research Day: Dublin. [Oral Presentation], Royal College of Surgeons in Ireland Research Day, Dublin , 01-MAR-98 - 01-MAR-98.
Phillips, C.; (1998) European Association for the Study of Diabetes: Barcelona 1998. [Oral Presentation], European Association for the Study of Diabetes, Barcelona , 01-JAN-98.
Phillips, C.; (1998) Irish Hyperlipidaemia Association: Belfast. [Oral Presentation], Irish Hyperlipidaemia Association, Belfast , 01-MAR-98 - 01-MAR-98.
Phillips, C; (1999) Irish Hyperlipidaemia Association: Dublin. [Oral Presentation], Irish Hyperlipidaemia Association, Dublin , 01-MAR-99 - 01-MAR-99.
Phillips, C.; (1999) Irish Endocrine Society: Belfast. [Oral Presentation], Irish Endocrine Society, Belfast , 01-MAR-99 - 01-MAR-99.
Phillips,C; (1999) Royal College of Surgeons in Ireland Research Day: Dublin. [Oral Presentation], Royal College of Surgeons in Ireland Research Day, Dublin , 01-MAR-99 - 01-MAR-99.
Phillips, C.; (1999) British Hyperlipidaemia Association: Cambridge. 1999. [Oral Presentation], British Hyperlipidaemia Association, Cambridge , 01-JAN-99.
Phillips, C.; (1999) European Association for the Study of Diabetes: Brussels 1999. [Oral Presentation], European Association for the Study of Diabetes, Brussels , 01-JAN-99.
Phillips, C; (2000) Royal College of Surgeons in Ireland Research Day: Dublin. [Poster Presentation], Royal College of Surgeons in Ireland Research Day, Dublin , 01-MAR-00 - 01-MAR-00.
Phillips, C; (2000) Irish Hyperlipidaemia Association: Belfast. [Oral Presentation], Irish Hyperlipidaemia Association, Belfast , 01-MAR-00 - 01-MAY-00.
Phillips, C.; (2000) European Association for the Study of Diabetes: Jerusalem 2000. [Oral Presentation], European Association for the Study of Diabetes, Jerusalem , 01-JAN-00.
Phillips, C.; (2000) The Biochemical Society: Belfast. 2000. [Oral Presentation], The Biochemical Society, Belfast , 01-JAN-00.
Phillips, C.; (2001) International Symposium on Diabetes and Atherosclerosis: Troon, Scotland. 2001. [Oral Presentation], International Symposium on Diabetes and Atherosclerosis, Troon, Scotland , 01-JAN-01.
Phillips, C; (2001) Irish Angiology Association, Dublin. [Oral Presentation], Irish Angiology Association, Dublin , 01-MAY-01 - 02-MAY-01.
Phillips, C; (2001) Irish Hyperlipidaemia Association: Dublin. [Oral Presentation], Irish Hyperlipidaemia Association, Dublin , 01-MAY-01 - 01-MAY-01.
Phillips, C.; (2001) European Atherosclerosis Society: Glasgow 2001. [Oral Presentation], European Atherosclerosis Society, Glasgow , 01-JAN-01.
Phillips, C.; (2001) European Association for the Study of Diabetes: Glasgow 2001. [Oral Presentation], European Association for the Study of Diabetes, Glasgow , 01-JAN-01.
Phillips, C.; (2002) European Association for the Study of Diabetes: Budapest 2002. [Oral Presentation], European Association for the Study of Diabetes, Budapest , 01-JAN-02.
Phillips, C.; (2002) European Atherosclerosis Society: Salzburg 2002. [Oral Presentation], European Atherosclerosis Society, Salzburg , 01-JAN-02.
Phillips, C; (2002) Irish Endocrine Society. [Poster Presentation], Irish Endocrine Society, Dublin , 01-MAY-02 - 01-MAY-02.
Phillips, C; (2002) Irish Hyperlipidaemia Association: Dublin. [Oral Presentation], Irish Hyperlipidaemia Association, Dublin , 01-MAY-02 - 01-MAY-02.
Phillips, C.; (2003) International Diabetes Federation: Paris 2003. [Oral Presentation], International Diabetes Federation, Paris , 01-JAN-03.
Phillips, C; (2003) Irish Endocrine Society. [Poster Presentation], Irish Endocrine Society, Belfast , 01-MAY-03 - 02-MAY-03.
Phillips, C.; (2004) European Nutrigenomics Organisation: Wageningen 2004. [Oral Presentation], European Nutrigenomics Organisation, Wageningen , 01-JAN-04.
Phillips, C.; (2006) LIPGENE Community Meeting: Marseille 2006. [Oral Presentation], LIPGENE Community Meeting, Marseille , 01-JAN-06.
Phillips, C.; (2006) Rank Prize Nutrigenomics Meeting: Windermere 2006. [Oral Presentation], Rank Prize Nutrigenomics Meeting, Windermere , 01-JAN-06.
Phillips, C.; (2007) European Atherosclerosis Society: Helsinki 2007. [Oral Presentation], European Atherosclerosis Society, Helsinki , 01-JAN-07.
Phillips, C.; (2007) LIPGENE Community Meeting: Cordoba 2007. [Oral Presentation], LIPGENE Community Meeting, Cordoba , 01-JAN-07.
Phillips, C.; (2007) Nutrition Society Meeting, Coleraine 2007. [Oral Presentation], Nutrition Society Meeting, Coleraine , 01-JAN-07.
               

Publications

 

Book Chapters

CM Phillips and HM Roche (2013) 'Modulating the risk of obesity and diabetes through Nutrigenetics' In: Lynette R Ferguson (eds). Nutrigenetics and nutrigenomics in functional foods and personalised nutrition. Boca Raton, FL 33487: CRC Press. [Details]
CM Phillips (2013) 'Nutrigenetics and metabolic disease: current status and implications for personalised nutrition' In: Leah Coles (eds). The Connection Between Nutrition, Health and Food Science. New Jersey 08758 USA: Apple Academic Press. [Details]
 

Peer Reviewed Journals

Roche HM, Phillips C & Gibney MJ.; (2005) 'The metabolic syndrome: the cross roads of diet and genetics'. Proceedings of the Nutrition Society, 64 :371-377. [Details]
Lairon D, Szabo de Edelenyi F, Goumidi L, Bertrais S, Phillips C, Macmanus R, Roche H, Planells R, ; (2008) 'Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest'. Gene, 3 (3-4):173-176. [DOI] [Details]
Phillips CM, Kesse-Guyot E, McManus R, Hercberg S, Lairon D, Planells R, Roche HM (2012) 'High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults'. Nutrition, 142 (5):824-831. [DOI] [Details]
Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, Gjelstad IM, Lopez-Miranda J, Kiec-Klimczak M, Malczewska-Malec M, Drevon CA, Hall W, Lovegrove JA, Karlstrom B, Risérus U, Roche HM (2012) 'Obesity and Body Fat Classification in the Metabolic Syndrome: Impact on Cardiometabolic Risk Metabotype'. Obesity, . [DOI] [Details]
Millar SR, Perry IJ, Phillips CM. (2015) 'HbA1c alone is a poor indicator of cardiometabolic risk in middle-aged subjects with pre-diabetes but is suitable for type 2 diabetes diagnosis: a cross-sectional study'. PLoS ONE, 10(8):e0134154 . [DOI] [Details]
Phillips CM, Perry IJ. (2015) 'Lipoprotein particle subclass profiles among metabolically healthy and unhealthy obese and non-obese adults: does size matter?'. Atherosclerosis, 242 (2):399-406. [DOI] [Details]
Millar SR, Perry IJ, Phillips CM. (2015) 'Assessing cardiometabolic risk in middle-aged adults using body mass index and waist-height ratio: are two indices better than one? A cross-sectional study'. Diabetology and Metabolic Syndrome, 7 (7):73. [DOI] [Details]
Phillips CM, Perry IJ. (2015) 'Depressive symptoms, anxiety and well-being among metabolic health obese subtypes'. Psychoneuroendocrinology, 62 :47-53. [DOI] [Details]
Phillips CM. (2016) 'Metabolically Healthy Obesity: Personalised and Public Health Implications'. Trends in Endocrinology and Metabolism, 27 (4):189-191. [DOI] [Details]
Meegan AP, Perry IJ, Phillips CM. (2017) 'The Association between Dietary Quality and Dietary Guideline Adherence with Mental Health Outcomes in Adults: A Cross-Sectional Analysis'. Nutrients, 9 (3). [DOI] [Details]
Phillips CM. (2017) 'Metabolically healthy obesity across the life course: epidemiology, determinants, and implications'. Annals of the New York Academy of Sciences, 1391 (1):85-100. [DOI] [Details]
Murtagh MJ, Ferretti V, Burton PR, Gaye A, Marcon Y, Isaeva J, LaFlamme P, Turner A, Jones EM, Minion J, Boyd AW, Newby CJ, Nuotio ML, Wilson R, Butters O, Murtagh B, Demir I, Doiron D, Giepmans L, Wallace SE, Budin-Ljøsne I, Oliver Schmidt C, Boffetta P, Boniol M, Bota M, Carter KW, deKlerk N, Dibben C, Francis RW, Hiekkalinna T, Hveem K, Kvaløy K, Millar S, Perry IJ, Peters A, Phillips CM, Popham F, Raab G, Reischl E, Sheehan N, Waldenberger M, Perola M, van den Heuvel E, Macleod J, Knoppers BM, Stolk RP, Fortier I, Harris JR, Woffenbuttel BH (2014) 'DataSHIELD: taking the analysis to the data, not the data to the analysis'. International Journal of Epidemiology, . [DOI] [Details]
Harrington JM, Phillips CM (2014) 'Nutrigenetics: bridging two worlds to understand type 2 diabetes'. Current Diabetes Reports, 14 (4). [DOI] [Details]
Phillips CM, Kearney PM, McCarthy VJ, Harrington JM, Fitzgerald AP, Perry IJ (2013) 'Comparison of diabetes risk score estimates and cardiometabolic risk profiles in a middle-aged Irish population'. PLoS ONE, 8 (11). [DOI] [Details]
Delgado-Lista J, Perez-Martinez P, Garcia-Rios A, Phillips CM, Hall W, Gjelstad IM, Lairon D, Saris W, KieĿ-Wilk B, Karlström B, Drevon CA, Defoort C, Blaak EE, Dembinska-KieĿ A, Risérus U, Lovegrove JA, Roche HM, Lopez-Miranda J (2013) 'A gene variation (rs12691) in the CCAT/enhancer binding protein α modulates glucose metabolism in metabolic syndrome'. Nutrition, Metabolism and Cardiovascular Diseases, 23 (5):417-423. [DOI] [Details]
Phillips CM (2013) 'Nutrigenetics and metabolic disease: current status and implications for personalised nutrition'. Nutrients, 5 (1):32-57. [DOI] [Details]
Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, Gjelstad IM, Lopez-Miranda J, Kiec-Klimczak M, Malczewska-Malec M, Drevon CA, Hall W, Lovegrove JA, Karlstrom B, Risérus U, Roche HM (2013) 'Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype'. Obesity, 21 (1):1-61. [DOI] [Details]
Phillips CM (2013) 'Metabolically healthy obesity: definitions, determinants and clinical implications'. Reviews in Endocrine and Metabolic Disorders, 14 (3):219-227. [DOI] [Details]
Phillips CM, Perry IJ (2013) 'Does inflammation determine metabolic health status in obese and nonobese adults?'. Journal of Clinical Endocrinology and Metabolism, 98 (10):1-9. [DOI] [Details]
Phillips CM, Dillon C, Harrington JM, McCarthy VJ, Kearney PM, Fitzgerald AP, Perry IJ (2013) 'Defining metabolically healthy obesity: role of dietary and lifestyle factors'. PLoS ONE, 8 (10). [DOI] [Details]
Perez-Martinez P, Phillips CM, Delgado-Lista J, Garcia-Rios A, Lopez-Miranda J, Perez-Jimenez F (2013) 'Nutrigenetics, metabolic syndrome risk and personalized nutrition'. Vascular Pharmacology, 11 (6):946-953. [Details]
Oliver, E., McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Phillips, C. M., Ferguson, J. F., Roche, H. M. (2012) 'Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA'. J Nutr Biochem, 23 (9):1192-200. Available Online [Details]
Phillips CM, Goumidi L, Bertrais S, Field MR, McManus R, Hercberg S, Lairon D, Planells R, Roche HM (2012) 'Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome'. Journal of Nutritional Biochemistry, 23 (3):239-244. [DOI] [Details]
Phillips CM, Kesse-Guyot E, Ahluwalia N, McManus R, Hercberg S, Lairon D, Planells R, Roche HM (2012) 'Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk'. Atherosclerosis, 220 (2):513-519. [DOI] [Details]
Garcia-Rios A, Perez-Martinez P, Delgado-Lista J, Phillips CM, Gjelstad IM, Wright JW, Karlström B, Kiec-Wilk B, van Hees AM, Helal O, Polus A, Defoort C, Riserus U, Blaak EE, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J (2012) 'A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome'. Nutrition, 142 (7):1213-1218. [DOI] [Details]
Garcia-Rios A, Delgado-Lista J, Perez-Martinez P, Phillips CM, Ferguson JF, Gjelstad IM, Williams CM, Karlström B, KieĿ-Wilk B, Blaak EE, Lairon D, Planells R, Malczewska-Malec M, Defoort C, Riserus U, Saris WH, Lovegrove JA, Drevon CA, Roche HM, Lopez-Miranda J (2011) 'Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism'. Atherosclerosis, 218 (2):416-422. [DOI] [Details]
Delgado-Lista J, Perez-Martinez P, García-Rios A, Phillips CM, Williams CM, Gulseth HL, Helal O, Blaak EE, Kiec-Wilk B, Basu S, Drevon CA, Defoort C, Saris WH, Wybranska I, Riserus U, Lovegrove JA, Roche HM, Lopez-Miranda J (2011) 'Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study'. Atherosclerosis, 214 (1):110-116. [DOI] [Details]
Phillips CM, Goumidi L, Bertrais S, Field MR, McManus R, Hercberg S, Lairon D, Planells R, Roche HM (2011) 'Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk'. Atherosclerosis, 214 (2):408-414. [DOI] [Details]
Oliver E, McGillicuddy F, Phillips C, Toomey S, Roche HM (2010) 'The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA'. Proceedings of the Nutrition Society, 69 (2):232-243. [DOI] [Details]
Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, Defoort C, Lovegrove JA, Drevon CA, Gibney MJ, Blaak EE, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. (2010) 'Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome'. Journal of lipid research, 51 (7):1793-1800. [Details]
Phillips CM, Goumidi L, Bertrais S, Field MR, Ordovas JM, Cupples LA, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Gibney MJ, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. (2010) 'Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults'. Nutrition, 140 (2):238-244. [Details]
Ferguson JF, Phillips CM, Tierney AC, Pérez-Martínez P, Defoort C, Helal O, Lairon D, Planells R, Shaw DI, Lovegrove JA, Gjelstad IM, Drevon CA, Blaak EE, Saris WH, Leszczynska-Golabek I, Kiec-Wilk B, Risérus U, Karlström B, Miranda JL, Roche HM (2010) 'Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance'. American Journal of Clinical Nutrition, 91 (3):794-801. [DOI] [Details]
Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Mehegan J, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM (2010) 'Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components'. Journal of Clinical Endocrinology and Metabolism, 95 (3):1386-1394. [DOI] [Details]
Ferguson JF, Phillips CM, McMonagle J, Pérez-Martínez P, Shaw DI, Lovegrove JA, Helal O, Defoort C, Gjelstad IM, Drevon CA, Blaak EE, Saris WH, Leszczyſska-Goſabek I, Kiec-Wilk B, Risérus U, Karlström B, Lopez-Miranda J, Roche HM (2010) 'NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids'. Atherosclerosis, 211 (2):539-544. [DOI] [Details]
Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McMonagle J, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Kiec-Wilk B, Riserus U, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM; (2010) 'ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat'. Journal of Lipid Research, 51 (12):3500-3507. [DOI] [Details]
Roche HM, Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, ; (2009) 'Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome'. American Journal of Clinical Nutrition, . [DOI] [Details]
Roche HM, Phillips CM, Goumidi L, Bertrais S, Field MR, Peloso GM, Shen J, McManus R, Hercberg S, Lairon D, Planells R, ; (2009) 'Dietary Saturated Fat Modulates the Association between STAT3 Polymorphisms and Abdominal Obesity in Adults'. Nutrition, . [DOI] [Details]
Lairon D, Szabo de Edelenyi F, Goumidi L, Bertrais S, Phillips C, Macmanus R, Roche H, Planells R, ; (2008) 'Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest'. Genes And Nutrition, 3 (3-4):173-176. [DOI] [Details]
Roche HM, Phillips CM, Tierney AC, ; (2008) 'Gene-nutrient interactions in the metabolic syndrome'. Journal Of Nutrigenetics And Nutrigenomics, 1 (3):136-151. [DOI] [Details]
Phillips, CM; Goumidi, L; Bertrais, S; Ferguson, J; McManus, R; Hercberg, S; Lairon, D; Roche, HM; Planells, R; ; (2007) 'Interaction between dietary fatty acids and genetic variation in the metabolic syndrome'. Atherosclerosis Supp, 8 :45-45. [Details]
Phillips C, Lopez-Miranda J, Perez-Jimenez F, McManus R & Roche HM. ; (2006) 'Genetic and nutrient determinants of the metabolic syndrome'. Current Opinion in Cardiology, 3 (21):185-193. [Details]
Phillips C, Owens D, Collins P, Tomkin GH.; (2006) 'Intestinal microsomal triglyceride transfer protein in type 2 diabetic and non-diabetic subjects: The relationship to triglyceride-rich postprandial lipoprotein composition'. Atherosclerosis, 187 (1):57-64. [Details]
Phillips C, Owens D, Collins P, Tomkin GH.; (2005) 'Low density lipoprotein non-esterified fatty acids and lipoprotein lipase in diabetes'. Atherosclerosis, 181 :109-114. [Details]
Roche HM, Phillips C, Gibney MJ; (2005) 'The Metabolic Syndrome: the cross roads of diet and genetics'. Proceedings of the Nutrition Society, 64 (3):371-377. [Details]
Phillips C, Mullan K, Owens D, Tomkin GH.; (2004) 'A common microsomal triglyceride transfer protein polymorphism significantly reduces low density lipoprotein cholesterol in type 2 diabetic patients through its effect on the triglyceride-rich lipoproteins'. QJM: An International Journal of Medicine, 97 :211-218. [Details]
Phillips C, Madigan C, Owens D, Collins P, Tomkin GH. ; (2002) 'Defective chylomicron synthesis as a cause of delayed particle clearance in diabetes?'. International Journal of Experimental Diabetes Research, 2 :171-178. [Details]
Phillips C, Owens D, Collins P, Tomkin GH.; (2002) 'Microsomal triglyceride transfer protein: The role of insulin resistance in the regulation of chylomicron assembly'. Atherosclerosis, 160 :355-360. [Details]
Phillips C, Anderton K, Bennett A, Owens D, Collins P, Johnson A, Tomkin GH.; (2002) 'Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidaemia in diabetes'. Metabolism, 51 :847-852. [Details]
Phillips C, Murugasu G, Owens D, Collins P, Johnson A, Tomkin GH. ; (2000) 'Improved metabolic control reduces the number of postprandial apolipoprotein B48-containing particles in Type 2 diabetes'. Atherosclerosis, 148 :283-291. [Details]
 

Conference Publications

Oliver, E,McGillicuddy, F,Phillips, C,Toomey, S,Roche, HM (2010) PROCEEDINGS OF THE NUTRITION SOCIETY Postgraduate Symposium The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA , pp.232-243 [DOI] [Details]
                       

Abstract

Phillips C, Muragasu G, Owens D, Collins P, Johnson A, Tomkin GH.; (1998) Effect of diabetic control on post-prandial cholesterol transfer to atherogenic lipoproteins. Abstract [Details]
Muragasu G, Phillips C, Owens D, Collins P, Johnson A, Tomkin GH. ; (1998) Effect of improvement in glycaemic control on apo B48 and post-prandial lipoproteins in non-insulin-dependent diabetes. Abstract [Details]
Phillips C, Madigan C, Owens D, Collins P, Johnson A, Tomkin GH.; (1999) The role of diabetes in delayed chylomicron clearance. Abstract [Details]
Phillips C, Madigan C, Owens D, Collins P, Johnson A, Tomkin GH. ; (1999) Altered chylomicron apo B48 composition and clearance in diabetes. Abstract [Details]
Phillips C, Murugasu G, Ryan M, Owens D, Collins P, Johnson A, Tomkin GH. ; (1999) Improved glycaemic control in type 2 diabetes: effect of metformin on post-prandial lipoproteins. Abstract [Details]
Owens D, C Phillips, G Murugasu, M Ryan, D Owens, P Collins, A Johnson, Tomkin GH.; (1999) Improved glycaemic control in type 2 diabetes: Effect of metformin on postprandial lipoproteins. Abstract [Details]
Phillips C, Anderton K, Bennett A, Madigan C, Owens D, Collins P, Tomkin GH.; (2000) Increased Microsomal triglyceride transfer protein in diabetic rabbits. The cause of elevated postprandial apo B48-containing chylomicrons?. Abstract [Details]
Tomkin GH, Phillips C, Anderton K, Bennett A, Madigan C, Collins P, Owens D.; (2000) Increased microsomal triglyceride transfer protein (MTP) expression in the intestine but not the liver of diabetic rabbits. Abstract [Details]
Phillips C, Owens D, Collins P, Tomkin GH.; (2001) Altered expression of microsomal triglyceride transfer protein and increased lymph chylomicron production in the insulin resistant zucker obese fa/fa rat. Abstract [Details]
Mullan K, Phillips C, Owens D, Collins P, Tomkin GH.; (2002) Relationship between microsomal triglyceride transfer protein and postprandial lipoproteins in type 2 diabetes. Abstract [Details]
Phillips C, Bell M, Owens D, P Collins, Tomkin GH.; (2002) A common microsomal triglyceride transfer protein polymorphism 493 G/T is associated with increased small chylomicron particles in diabetes. Abstract [Details]
Phillips C, Owens D, Collins P, Tomkin GH. ; (2002) Free fatty acids and low density lipoprotein oxidation in type 2 diabetes. Abstract [Details]
Owens D, Phillips C, Bell M, Collins P, Tomkin GH.; (2002) Type 2 diabetic patients have increased free fatty acids in their LDL. Abstract [Details]
Phillips C, Bell M, Owens D, Collins P, Tomkin GH.; (2002) A common microsomal triglyceride transfer protein polymorphism 493 G/T is associated with increased small chylomicron particles in diabetes. Abstract [Details]
Phillips C, Owens D, Collins P, Tomkin GH. ; (2002) Compositional abnormalities of low density lipoprotein in type 2 diabetes: An explanation for increased atherogenicity?. Abstract [Details]
Mullan K, Phillips C, Owens D, Collins P, Tomkin GH.; (2002) Relationship between intestinal microsomal triglyceride transfer protein and postprandial lipoproteins in Type 2 diabetic patients. Abstract [Details]
Mullan K, Phillips C, Owens D, Tomkin GH. ; (2003) Intestinal microsomal triglyceride transfer protein is raised in diabetic patients. A mechanism for production of atherogenic postprandial lipoproteins. Abstract [Details]
Mullan K, Phillips C, Owens D, Tomkin GH.; (2003) Human microsomal triglyceride transfer protein: The effect of HMGCoA reductase inhibition. Abstract [Details]
Mullan K, Phillips C, Owens D, Tomkin GH.; (2003) Increased intestinal microsomal triglyceride transfer protein in diabetes is related to increased cholesterol content but not triglyceride content of intestinally-derived particles. Abstract [Details]
Owens D, Phillips C, Mullan K, Tomkin GH. ; (2004) The role of MTP in postprandial lipoprotein metabolism. Abstract [Details]
Mullan K, Phillips C, Owens D, Tomkin GH.; (2004) Microsomal triglyceride transfer protein and triglyceride-rich lipoprotein metabolism in type 2 diabetes. Abstract [Details]
Phillips C, Goumidi L, Bertrais S, Ferguson J, McManus R, Hercberg S, Lairon D, Roche HM, Planells R; (2007) Interaction between dietary fatty acids and genetic variation in the metabolic syndrome. Abstract [Details]
                                                                                       

Research

Research Interests

Current research interests include dietary, lifestyle and clinical determinants of the metabolically healthy obese phenotype, cardiometabolic risk prediction, genetic and environmental (dietary/lifestyle) determinants of childhood, maternal, morbid adult and intergenerational obesity.

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health (ALPHABET)
Start Date / End Date : 01-JAN-17 / 31-AUG-19

Recent Postgraduates

 

Teaching

Teaching Philosophy

Developed and delivered the Research Methods in Genetic Epidemiology module as part of the Masters in Public Health in UCD.

Lectures on Nutrigenetics as part of the PhD in Molecular Medicine and BSc in Human Nutrition and Dietetics courses in TCD.

 

Enhancement of Teaching

Review and Enhancement of Curriculum

Developing as a Teacher

Innovation & Leadership

Collaborators

Internal Collaborators

Prof. Cecily Kelleher, School of Public Health, Physiotherapy and Sports Science, University College Dublin

Prof. Fionnuala McAuliffe, National Maternity Hospital

Prof. Donal O'Shea, St. Vincents Hospital

Prof Helen Roche, Conway Institute, University College Dublin

External Collaborators

Prof. Ivan Perry, Dept. of Epidemiology and Public Health, University College Cork 

Prof. Jim Otvos, University of North Carolina, USA

Prof James Hebert and Dr Nitin Shivappa, University of South Carolina, USA 

Prof Caroline Relton and Dr Matthew Suderman, University of Bristol, UK 

Prof Nicholas Harvey, University of Southampton, UK
 
Dr Barbara Heude, INSERM UMR 1153, France
 
Dr Liesbeth Duijts,  Erasmus MC, University Medical Center Rotterdam, Netherlands
 
Prof Kinga Polanska, Nofer Institute of Occupational Medicine, Poland