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Ricardo Segurado

Lecturer/Assistant Professor

School Of Public Hlth, Phys & Sports Sci
Woodview House
Belfield
Dublin 4

Tel: 353 1 7163090
Email: ricardo.segurado@ucd.ie

Biography

Dr Ricardo Segurado is a Lecturer in Public Health Biostatistics in the School of Public Health, Physciotherapy and Sports Sciences, and a consultant biostatistician affiliated with CSTAR.

His background is in biochemistry, and genetics (Trinity College Dublin).  He took up a postdoctoral position in statistical genetics and genetic epidemiology research in Cardiff University, and returned to Dublin on being awarded a HRB postdoctoral fellowship studying gene-gene interaction at TCD.

He has a dozen years experience of statistical consulting on a range of research projects in health and biological sciences, including studies in areas as diverse as molecular genetics, neurology, immunology and psychiatry. Ricardo is actively involved in developing statistical education amongst biological and clinical researchers and is a founder of the Wales-Ireland Genetic Epidemiology Group. 

Professional

 

Associations

Association: Society for Social Medicine, Function/Role: Member
Association: International Biometric Society, Function/Role: Member
Association: Irish Statistical Association, Function/Role: Member
Association: Royal Statistical Society, Function/Role: Fellow
Association: International Genetic Epidemiology Society, Function/Role: Member
           

Education

Year 2000 Institution: Trinity College Dublin
Qualification: PG DIP Subject: Postgraduate Diploma in Statistics
Year 2003 Institution: Trinity College Dublin
Qualification: PhD Subject: PhD in Molecular Genetics
Year 1997 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject: Biochemistry

Languages

French:
Portuguese:
English:
       

Publications

 

Book Chapters

Louise Gallagher, Mark A Bellgrove, Ziarih Hawi, Ricardo Segurado, Michael Fitzgerald; (2007) 'ADHD, Autism Spectrum Disorders and Tourette's Syndrome: Investigating the Evidence for Clinical and Genetic Overlap' In: Louise Gallagher, Mark A Bellgrove, Ziarih Hawi, Ricardo Segurado, Michael Fitzgerald; (eds). Handbook of Attention Deficit Hyperactivity Disorder. Chichester: Wiley-Blackwell. [Details]
 

Peer Reviewed Journals

O'Connor C, Farah N;O'Higgins A;Segurado R;Fitzpatrick C;Turner MJ;Stuart B;Kennelly MM (2013) 'Longitudinal measurement of fetal thigh soft tissue parameters and its role in the prediction of birth weight'. Prenatal Diagnosis, 33 (10):945-951. [DOI] [Details]
Roy AK, McCullagh BN;Segurado R;McGorrian C;Keane E;Keaney J;Fitzgibbon MN;Mahon NG;Murray PT;Gaine SP (2014) 'Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes'. Journal of Cardiac Failure, 20 (1):31-37. [DOI] [Details]
O'Connor C, Doolan A;O'Higgins A;Segurado R;Sheridan-Pereiraet M;Turner MJ;Stuart B;Kennelly MM (2014) 'Fetal subcutaneous tissue measurements in pregnancy as a predictor of neonatal total body composition'. Prenatal Diagnosis, 34 (10):952-955. [DOI] [Details]
O'Connor C, O'Higgins A;Doolan A;Segurado R;Stuart B;Turner MJ;Kennelly MM (2014) 'Birth weight and neonatal adiposity prediction using fractional limb volume obtained with 3D ultrasound'. Fetal Diagnosis and Therapy, 36 (1):44-48. [DOI] [Details]
Ryan, MF and O'Grada, CM and Morris, C and Segurado, R and Walsh, MC and Gibney, ER and Brennan, L and Roche, HM and Gibney, MJ (2014) 'Within-person variation in the postprandial lipemic response of healthy adults (vol 97, pg 261, 2013)'. American Journal of Clinical Nutrition, 100 (4):1214-1214. [Details]
Roche E, Lyne JP, O'Donoghue B, Segurado R, Kinsella A, Hannigan A, Kelly BD, Malone K, Clarke M (2015) 'The factor structure and clinical utility of formal thought disorder in first episode psychosis'. Schizophrenia Research, 168 (1-2):92-98. [DOI] [Details]
Mone F, Harrity C, Mackie A, Segurado R, Toner B, McCormick TR, Currie A, McAuliffe FM (2015) 'Vaginal birth after caesarean section prediction models: a UK comparative observational study'. European Journal of Obstetrics, Gynecology and Reproductive Biology, 193 :136-139. [DOI] [Details]
Walsh JM, Segurado R, Mahony RM, Foley ME, McAuliffe FM (2015) 'The Effects of Fetal Gender on Maternal and Fetal Insulin Resistance'. PLoS ONE, 10 (9). [DOI] [Details]
O' Sullivan KE, Hurley ET, Segurado R, Sugrue D, Hurley JP (2015) 'Transaortic TAVI Is a Valid Alternative to Transapical Approach'. Journal of Cardiac Surgery, 30 (5):381-390. [DOI] [Details]
O'Brien SA, Livingstone MB, McNulty BA, Lyons J, Walton J, Flynn A, Segurado R, Dean M, Spence M, McCaffrey TA, Pourshahidi LK, Nugent AP, Gibney ER (2015) 'Secular trends in reported portion size of food and beverages consumed by Irish adults'. British Journal of Nutrition, 113 (7):1148-1157. [DOI] [Details]
Elfil H, Crowley L, Segurado R, Spring A (2015) 'A randomised controlled trial of the effect of a head-elevation pillow on intrathecal local anaesthetic spread in caesarean section'. International Journal of Obstetric Anesthesia, 24 (4):303-307. [DOI] [Details]
Hurley ET, O'Sullivan KE, Segurado R, Hurley JP (2015) 'A Meta-Analysis Examining Differences in Short-Term Outcomes Between Sutureless and Conventional Aortic Valve Prostheses'. Innovations (Philadelphia, Pa.), 10 (6):375-382. [DOI] [Details]
Roche E, Segurado R, Renwick L, McClenaghan A, Sexton S, Frawley T, Chan C, Bonar M, Clarke M (2016) 'Language disturbance and functioning in first episode psychosis'. Psychiatry Research, (235):29-37. [DOI] [Details]
Merikangas AK, Segurado R, Kelleher E, Hogan D, Delaney C, Gill M, Gallagher L, Corvin AP, Heron EA (2016) 'Parental age, birth order and neurodevelopmental disorders'. Molecular Psychiatry, 21 (6):728-730. [DOI] [Details]
Hurley DA, Hall AM, Currie-Murphy L, Pincus T, Kamper S, Maher C, McDonough SM, Lonsdale C, Walsh NE, Guerin S, Segurado R, Matthews J, SOLAS Trial Team (2016) 'Theory-driven group-based complex intervention to support self-management of osteoarthritis and low back pain in primary care physiotherapy: protocol for a cluster randomised controlled feasibility trial (SOLAS)'. BMJ Open, 6 (1):e010728. [DOI] [Details]
Cronin FM, Segurado R, McAuliffe FM, Kelleher CC, Tremblay RE (2016) 'Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study'. PLoS ONE, 11 (3). [DOI] [Details]
Cronin FM, Segurado R, McAuliffe FM, Kelleher CC, Tremblay RE (2016) 'Gestational age and chronic 'body-mind' health problems in childhood: dose-response association and risk factors'. European child & adolescent psychiatry, . [DOI] [Details]
Mone F, McConnell B, Thompson A, Segurado R, Hepper P, Stewart MC, Dornan JC, Ong S, McAuliffe FM, Shields MD (2016) 'Fetal umbilical artery Doppler pulsatility index and childhood neurocognitive outcome at 12 years'. BMJ Open, 6 (6):e008916. [DOI] [Details]
Meulenbroek O, O'Dwyer S;de Jong D;van Spijker G;Kennelly S;Cregg F;Olde Rikkert M;Abdullah L;Wallin A;Walsh C;Coen R;Kenny RA;Daly L;Segurado R;Borjesson-Hanson A;Crawford F;Mullan M;Lucca U;Banzi R;Pasquier F;Breuilh L;Riepe M;Kalman J;Molloy W;Tsolaki M;Howard R;Adams J;Gaynor S;Lawlor B (2016) 'European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer's disease-the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow'. BMJ Open, 6 (7):e011584. [DOI] [Details]
Roche E, Lyne J, O'Donoghue B, Segurado R, Behan C, Renwick L, Fanning F, Madigan K, Clarke M (2016) 'The prognostic value of formal thought disorder following first episode psychosis'. Schizophrenia Research, . [DOI] [Details]
McCarthy R, Segurado R, Crealey M, Twomey A (2016) 'Standardised versus Individualised Parenteral Nutrition. Further Food for Thought'. Irish Medical Journal, 109 (4):386. [Details]
Corry E, Mone F, Segurado R, Downey P, McParland P, McAuliffe FM, Mooney EE (2016) 'Placental disease and abnormal umbilical artery Doppler waveforms in trisomy 21 pregnancy: A case-control study'. Placenta, 47 :24-28. [DOI] [Details]
O'Connor C, O'Higgins A, Segurado R, Turner MJ, Stuart B, Kennelly MM (2016) 'Maternal arterial elasticity in the first trimester as a predictor of birthweight'. Journal of Obstetrics and Gynaecology, 22 :1-6. [DOI] [Details]
Hawi, Z., Segurado, R., Conroy, J., Sheehan, K., Lowe, N., Kirley, A., Shields, D., Fitzgerald, M., Gallagher, L., Gill, M. (2005) 'Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder'. Am J Hum Genet, 77 (6):958-65. Available Online [Details]
O'Connor C; Farah N; O'Higgins A; Segurado R; Fitzpatrick C; Turner MJ; Stuart B; Kennelly MM (2013) 'Longitudinal measurement of fetal thigh soft tissue parameters and its role in the prediction of birth weight'. Prenatal diagnosis, 33 (10):945-951. [Details]
Ryan, MF,Grada, CO,Morris, C,Segurado, R,Walsh, MC,Gibney, ER,Brennan, L,Roche, HM,Gibney, MJ (2013) 'Within-person variation in the postprandial lipemic response of healthy adults'. American Journal of Clinical Nutrition, 97 :261-267. [DOI] [Details]
Roy AK; McCullagh BN; Segurado R; McGorrian C; Keane E; Keaney J; Fitzgibbon MN; Mahon NG; Murray PT; Gaine SP (2014) 'Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes'. Journal of cardiac failure, 20 (1):31-37. [DOI] [Details]
O'Connor C; O'Higgins A; Segurado R; Turner MJ; Stuart B; Kennelly MM (2014) 'Maternal body composition and birth weight'. Prenatal diagnosis, 34 (6):605-607. [DOI] [Details]
O'Connor C; Doolan A; O'Higgins A; Segurado R; Sheridan-Pereiraet M; Turner MJ; Stuart B; Kennelly MM (2014) 'Fetal subcutaneous tissue measurements in pregnancy as a predictor of neonatal total body composition'. Prenatal diagnosis, 34 (10):952-955. [DOI] [Details]
O'Connor C; O'Higgins A; Doolan A; Segurado R; Stuart B; Turner MJ; Kennelly MM (2014) 'Birth weight and neonatal adiposity prediction using fractional limb volume obtained with 3D ultrasound'. Fetal Diagnosis And Therapy, 36 (1):44-48. [DOI] [Details]
Merikangas AK; Segurado R; Cormican P; Heron EA; Anney RJ; Moore S; Kelleher E; Hargreaves A; Anderson-Schmidt H; Gill M; Gallagher L; Corvin A (2014) 'The phenotypic manifestations of rare CNVs in schizophrenia'. Schizophrenia Research, 158 (1-3):255-260. [DOI] [Details]
O' Sullivan KE; Bracken-Clarke D; Segurado R; Barry M; Sugrue D; Flood G; Hurley J (2014) 'Is local anesthesia the optimum strategy in retrograde transcatheter aortic valve implantation? A systematic review and meta-analysis'. The Thoracic and cardiovascular surgeon, 62 (6):489-497. [DOI] [Details]
Lawlor B; Kennelly S; O'Dwyer S; Cregg F; Walsh C; Coen R; Kenny RA; Howard R; Murphy C; Adams J; Daly L; Segurado R; Gaynor S; Crawford F; Mullan M; Lucca U; Banzi R; Pasquier F; Breuilh L; Riepe M; Kalman J; Wallin A; Borjesson A; Molloy W; Tsolaki M; Olde Rikkert M (2014) 'NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease'. Bmj Open, 4 (10):e006364. [DOI] [Details]
Merikangas AK; Segurado R; Heron EA; Anney RJ; Paterson AD; Cook EH; Pinto D; Scherer SW; Szatmari P; Gill M; Corvin AP; Gallagher L (2015) 'The phenotypic manifestations of rare genic CNVs in autism spectrum disorder'. Molecular Psychiatry, 20 (11):1366-1372. [DOI] [Details]
O'Sullivan KE1, Gough A, Segurado R, Barry M, Sugrue D, Hurley J (2014) 'Is valve choice a significant determinant of paravalular leak post-transcatheter aortic valve implantation? A systematic review and meta-analysis'. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 45 (5):826-833. [DOI] [Details]
Collison M; Chin JL; Abu Shanab A; Mac Nicholas R; Segurado R; Coughlan S; Connell J; Carr MJ; Merriman RB; McCormick PA; Hall WW (2015) 'Homozygosity for HLA group 2 alleles predicts treatment failure with interferon-α and ribavirin in chronic hepatitis C virus genotype 1 infection'. Journal of Interferon Cytokine Research, 35 (2):126-133. [DOI] [Details]
Mone F, Walsh C, Mulcahy C, McMahon CJ, Farrell S, MacTiernan A, Segurado R, Mahony R, Higgins S, Carroll S, McParland P, McAuliffe FM (2015) 'Prenatal detection of structural cardiac defects and presence of associated anomalies: a retrospective observational study of 1262 fetal echocardiograms'. Prenatal Diagnosis, 35 (6):577-582. [DOI] [Details]
Onwuneme C, Martin F, McCarthy R, Carroll A, Segurado R, Murphy J, Twomey A, Murphy N, Kilbane M, McKenna M, Molloy E (2015) 'The Association of Vitamin D Status with Acute Respiratory Morbidity in Preterm Infants'. The Journal of pediatrics, 166 (5):1175-1180.e1. [DOI] [Details]
O'Connor C, Doolan A, O'Higgins A, Segurado R, Sheridan-Pereira M, Fitzpatrick C, Turner MJ, Stuart B, Kennelly MM (2015) 'Maternal body composition in the first trimester as a predictor of neonatal body composition after birth'. Obesity research & clinical practice, . [DOI] [Details]
Onwuneme C, Carroll A, Doherty D, Bruell H, Segurado R, Kilbane M, Murphy N, McKenna MJ, Molloy EJ (2015) 'Inadequate vitamin D levels are associated with culture positive sepsis and poor outcomes in paediatric intensive care'. Acta Paediatrica, International Journal of Paediatrics, . [DOI] [Details]
Killeen H; Shiel A; Law M; Segurado R; O'Donovan D (2015) 'The impact of preterm birth on participation in childhood occupation'. European Journal of pediatrics, 174 (3):299-306. [DOI] [Details]
Campbell VA, Segurado R, Lynch MA; (1998) 'Regulation of intracellular Ca2+ concentration by interleukin-1beta in rat cortical synaptosomes: an age-related study'. Neurobiology of Aging, 19 (6):575-579. [Details]
Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D, Heron J, Comerford C, Middle F, Corvin A, Pelios G, Kirov G, Larsen B, Mulcahy T, Williams N, O'Connell R, O'Mahony E, Payne A, Owen M, Holmans P, Craddock N, Gill M; (2002) 'The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report'. Molecular Psychiatry, 7 (2):189-200. [DOI] [Details]
Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lönnqvist J, Nöthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N; (2003) 'Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder'. American Journal of Human Genetics, 73 (1):49-62. Available Online [Details]
Levinson DF, Levinson MD, Segurado R, Lewis CM; (2003) 'Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis'. American Journal of Human Genetics, 73 (1):17-33. [DOI] [Details]
Lambert D, Middle F, Hamshere ML, Segurado R, Raybould R, Corvin A, Green E, O'Mahony E, Nikolov I, Mulcahy T, Haque S, Bort S, Bennett P, Norton N, Owen MJ, Kirov G, Lendon C, Jones L, Jones I, Holmans P, Gill M, Craddock N; (2005) 'Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22'. Molecular Psychiatry, 10 (9):831-841. [DOI] [Details]
McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM (2005) 'Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q'. American Journal of Human Genetics, 77 (4):582-595. [DOI] [Details]
Hamshere ML, Bennett P, Williams N, Segurado R, Cardno A, Norton N, Lambert D, Williams H, Kirov G, Corvin A, Holmans P, Jones L, Jones I, Gill M, O'Donovan MC, Owen MJ, Craddock N; (2005) 'Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13'. Archives of General Psychiatry, 62 (10):1081-1088. [DOI] [Details]
Segurado R, Conroy J, Meally E, Fitzgerald M, Gill M, Gallagher L; (2005) 'Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31'. American Journal of Psychiatry, 162 (11):2182-2184. [DOI] [Details]
Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, Fitzgerald M, Gallagher L, Gill M; (2005) 'Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder'. American Journal of Human Genetics, 77 (6):958-965. [DOI] [Details]
Hamshere ML, Segurado R, Moskvina V, Nikolov I, Glaser B, Holmans PA; (2007) 'Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis'. BMC Proceedings, 1 Suppl 1 . Link to full text [Details]
Segurado R, Hamshere ML, Glaser B, Nikolov I, Moskvina V, Holmans PA; (2007) 'Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set'. BMC Proceedings, 1 Suppl 1 . Link to full text [Details]
Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Brayne C, Rubinsztein D, Gill M, Lawlor B, Lovestone S, Holmans P, O'Donovan M, Morris JC, Thal L, Goate A, Owen MJ, Williams J; (2007) 'Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants'. Human Molecular Genetics, 16 (8):865-873. [DOI] [Details]
Norton N, Williams HJ, Dwyer S, Carroll L, Peirce T, Moskvina V, Segurado R, Nikolov I, Williams NM, Ikeda M, Iwata N, Owen MJ, O'Donovan MC; (2007) 'Association analysis of AKT1 and schizophrenia in a UK case control sample'. Schizophrenia Research, 93 (1-3):58-65. [DOI] [Details]
Jones I, Hamshere M, Nangle JM, Bennett P, Green E, Heron J, Segurado R, Lambert D, Holmans P, Corvin A, Owen M, Jones L, Gill M, Craddock N; (2007) 'Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16'. American Journal of Psychiatry, 164 (7):1099-1104. [DOI] [Details]
Glaser B, Nikolov I, Chubb D, Hamshere ML, Segurado R, Moskvina V, Holmans P; (2007) 'Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests'. BMC Proceedings, 1 Suppl 1 . Link to full text [Details]
Li Y, Grupe A, Rowland C, Holmans P, Segurado R, Abraham R, Jones L, Catanese J, Ross D, Mayo K, Martinez M, Hollingworth P, Goate A, Cairns NJ, Racette BA, Perlmutter JS, O'Donovan MC, Morris JC, Brayne C, Rubinsztein DC, Lovestone S, Thal LJ, Owen MJ, Williams J; (2008) 'Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease'. Human Molecular Genetics, 17 (5):759-767. [DOI] Link to full text [Details]
O'Dushlaine C, Kenny E, Heron EA, Segurado R, Gill M, Morris DW, Corvin A; (2009) 'The SNP ratio test: pathway analysis of genome-wide association datasets'. Bioinformatics, 25 (20):2762-2763. [DOI] [Details]
Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira AF, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C.; (2010) 'Functional impact of global rare copy number variation in autism spectrum disorders'. Nature, 15 (466):368-372. Link to full text [Details]
Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer J; (2010) 'A genome-wide scan for common alleles affecting risk for autism'. Human Molecular Genetics, 15 (19-20):4072-4082. Link to full text [Details]
Heron EA, O'Dushlaine C, Segurado R, Gallagher L, Gill M; (2011) 'Exploration of empirical Bayes hierarchical modeling for the analysis of genome-wide association study data'. Biostatistics, 12 (3):445-461. [DOI] [Details]
Segurado R, Bellgrove MA, Manconi F, Gill M, Hawi Z; (2011) 'Epistasis between neurochemical gene polymorphisms and risk for ADHD'. European Journal of Human Genetics, 19 (5):577-582. [DOI] [Details]
Bridges M, Heron EA, O'Dushlaine C, Segurado R, Morris D, Corvin A, Gill M, Pinto C; (2011) 'Genetic classification of populations using supervised learning'. PLoS ONE, 6 (5). [DOI] Link to full text [Details]
Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, Maclean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W; (2011) 'Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms'. Molecular Psychiatry, . [DOI] Link to full text [Details]
Babar, M; Ryan, AW; Anderson, LA; Segurado, R; Turner, G; Murray, LJ; Murphy, SJ; Johnston, BT; Comber, H; Reynolds, JV; McManus, R (2012) 'Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma'. American Journal of Gastroenterology, 107 (9):1331-1341. [Details]
 

Conference Publications

Conroy J, Segurado R, Meally E, Stallings R, Fitzgerald M, Gill M, Ennis S and Gallagher L. ; (2004) Evidence of association for a susceptibility region for Autism on Chromosome 2q The XIIth World Congress on Psychiatric Genetics [Details]
Conroy J, Cochrane L, Segurado R, Meally E, Green A, Ennis S, Gill M and Gallagher L. ; (2005) Further evidence supporting the role of ITGA4 as a candidate gene for Autism The XIIIth World Congress on Psychiatric Genetics [Details]
                                                                                                               

LETTER

Donnelly JM, Segurado R;McAuliffe FM (2015) Response to 'Inconsistencies and inaccuracies in reporting on choice of endpoints and of statistical results in RCT of maternal diet by Lewis et¿¿¿al.'. LETTER [DOI] [Details]
                     

Research

Research Interests


Ricardo's research is mainly in the field of statistical genetics, especially the influence of non-additive effects of multiple genes on risk for disease. He studies the performance of statistical tests for genetic association in the presence of genetic heterogeneity and epistasis through simulation. He also has an interest in the properties of heritability estimates in unrelated, family, and twin samples.

He maintains an interest in meta-analysis methods, issues around the design and analysis of randomised controlled trials, and in the effect of measurement error on estimation.

Ricardo also provides biostatistical consulting within the Centre for Support and Training in Analysis and Research (CSTAR), for biomedical researchers across Ireland.
     

Teaching

Teaching Philosophy

My teaching philosophy centres firstly around the motivation of the student by stressing real-world applications and value and by demonstrating an enthusiasm for the subject matter. Careful pacing through the material is needed in a complex subject in which many students have poor confidence.