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Brendan Egan

Lecturer In Exercise Metabolism

School Of Public Hlth, Physio & Pop Sc
Woodview House
Belfield
Dublin 4

Tel: +353 1 7163419
Email: brendan.egan@ucd.ie

Biography

Brendan received his BSc in Sport and Exercise Science from the University of Limerick in 2003, before graduating from Loughborough University with distinction from the MSc in Sport and Exercise Nutrition programme. He returned to Ireland in late 2004 to commence doctoral studies under the supervision of Dr. Donal O'Gorman at Dublin City University. The focus of this research was on skeletal muscle adaptation to exercise, and in particular the continuity between acute molecular responses to individual bouts of exercise and the adaptations in skeletal muscle induced by exercise training. He was awarded his PhD in 2008, before moving on to the prestigious Karolinska Institute, Stockholm, Sweden. There, he completed his post-doctoral training in Prof. Juleen Zierath's Integrative Physiology group at the Department of Molecular Medicine and Surgery. Here his research, using animal and in vitro cell systems, focussed on the transcriptional regulation of skeletal muscle insulin resistance in Type 2 diabetes by small, non-coding RNAs. He joined the faculty at UCD in 2011, and currently holds a position as Lecturer in Sport and Exercise Science in the School of Public Health, Physiotherapy, and Population Science, covering modules in sports nutrition, exercise prescription and molecular exercise physiology. His current research interests concern the nutritional enhancement of performance across the lifespan, and the molecular regulation of skeletal muscle function and adaptation in exercise, health and ageing. On the sporting front, he has represented Sligo in Gaelic football at Senior inter-county level since 2003.

2015-Present: Lecturer in Exercise Metabolism, UCD School of Public Health, Physiotherapy, and Sports Science

2011-2015:
Lecturer in Sport and Exercise Science, UCD School of Public Health, Physiotherapy, and Population Science

2011-2014: Visiting Researcher, Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

2008-2010: Post-doctoral Fellow, Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

2004-2008: PhD, School of Health and Human Performance, Dublin City University

2003-2004: MSc Sport and Exercise Nutrition, Loughborough University, UK

1999-2003: BSc Sport and Exercise Science, University of Limerick



 

Professional

Honours and Awards

Year: 2010.
Title: Scholarship Award, Keystone Symposia on Diabetes & Islet Biology
Year: 2010.
Title: XII National Award for Research on Sports Medicine
Year: 2009.
Title: Young Investigator Award, Summer Research Conference on Glucose Transporter Biology & Diabetes

Associations

Association: The Physiological Society, Function/Role: Ordinary Member
Association: European Association for the Study of Diabetes (EASD), Function/Role: Member
Association: European College of Sport Science (ECSS), Function/Role: Member
     

Conference Contributions

Egan B, Dowling P, O'Connor PL, Carson BP, Zierath JR, O'Gorman DJ (2009) The effect of fourteen consecutive days of exercise training on the expression of metabolic and mitochondrial genes and their transcriptional regulators in skeletal muscle of previously untrained men: a time-course study. [Oral Presentation], FASEB Summer Research Conference: Glucose Transporter Biology & Diabetes, Lucca, Italy , 06-SEP-09 - 11-SEP-09.
Egan B, Dowling P, O'Connor PL, Zierath JR, O'Gorman DJ; (2010) Remodelling of the mitochondrial proteome from human skeletal muscle in response to fourteen consecutive days of exercise training. [Poster Presentation], Keystone Symposia: Islet Biology & Diabetes, Whistler, BC Canada , 12-APR-10 - 17-APR-10.
Egan B, Sjögren R, Franck N, Osler ME, Krook A, Zierath JR ; (2011) A novel miRNA upregulated in skeletal muscle from type 2 diabetic patients impairs insulin sensitivity in primary human skeletal muscle cells. [Poster Presentation], Keystone Symposia: Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction, Keystone, CO USA , 12-JAN-11 - 17-JAN-11.
Egan B, O'Connor PL, Zierath JR, O'Gorman DJ (2012) Time course of adaptation to short-term exercise training in human skeletal muscle. [Poster Presentation], 15th International Biochemistry of Exercise Conference, Stockholm, Sweden , 17-JUN-12 - 21-JUN-12.
Egan B, Sjögren RJO, Franck N, Osler ME, Katayama S, Kere J, Krook A, Zierath JR (2013) microRNA-1285 is elevated in skeletal muscle from type 2 diabetic patients and negatively regulates insulin sensitivity through downregulation of the branched-chain amino acid degradation pathway. [Oral Presentation], Copenhagen Bioscience Conferences: Genomics in Metabolism, Denmark , 03-NOV-13 - 06-NOV-13.
   

Education

Year 2003 Institution: University of Limerick
Qualification: BSc Subject: Sports and Exercise Science
Year 2004 Institution: Loughborough University
Qualification: MSc (With Distinction) Subject: Sport and Exercise Nutrition
Year 2008 Institution: Dublin City University (DCU), IRL
Qualification: PhD Subject: N/A
     

Journals Edited

American Journal Of Physiology-Regulatory Integrative And Comparative Physiology: Reviewer.
American Journal Of Physiology-Endocrinology And Metabolism: Reviewer.
Diabetologia: Reviewer.
Faseb Journal: Reviewer.
Proteomics: Reviewer.
Applied Physiology, Nutrition And Metabolism: Reviewer.
Journal Of Sports Science: Reviewer.
 

Publications

     

Peer Reviewed Journals

Egan B, Ashley DT, Kennedy E, O'Connor PL, O'Gorman DJ (2015) 'Higher rate of fat oxidation during rowing compared with cycling ergometer exercise across a range of exercise intensities'. Scandinavian Journal of Medicine and Science in Sports, . [DOI] [Details]
Sjogren RJ, Egan B, Katayama M, Zierath JR, Krook A. (2015) 'Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells'. Physiological Genomics, 47 (3):45-57. [DOI] [Details]
Krause M, Keane K, Rodrigues-Krause J, Crognale D, Egan B, De Vito G, Murphy C, Newsholme P (2014) 'Elevated levels of Extracellular Heat Shock Protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro'. Clinical science (London, England : 1979), 126 (10):739-752. [DOI] [Details]
Jiang LQ*, Franck N*, Egan B, Sjögren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A (2013) 'Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in Type 2 diabetic patients involves microRNA let-7'. American Journal of Physiology-Endocrinology and Metabolism, 305 (11):E1359-E1366. [DOI] [Details]
Egan B, O'Connor PL, Zierath JR, O'Gorman DJ (2013) 'Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle'. PLoS ONE, 8 (9). [DOI] [Details]
Egan B, Zierath JR (2013) 'Exercise metabolism and the molecular regulation of skeletal muscle adaptation'. Cell Metabolism, 17 (2):162-184. [DOI] [Details]
Iglesias-Gutierrez E, Egan B, Diaz-Martinez AE, Penalvo JL, Martinez-Camblor P, Garcia-Roves PM, Gonzalez-Medina A, O'Gorman DJ, Ubeda N (2012) 'Transient increase in homocysteine, but not hyperhomocysteinemia, during acute exercise at different intensities in young sedentary individuals'. PLoS ONE, 7 (12). [DOI] [Details]
Barres R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR ; (2012) 'Acute exercise remodels promoter methylation in human skeletal muscle'. Cell metabolism, 15 (3):405-411. [DOI] [Details]
Egan B, Dowling P, O'Connor PL, Henry M, Meleady P, Zierath JR, O'Gorman DJ; (2011) '2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'. Proteomics, 11 (8):1413-1428. [DOI] [Details]
Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ; (2010) 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'. Physiology, 588 (Pt 10):1779-1790. [DOI] [Details]
Egan B, Zierath JR; (2009) 'Hunting for the SNARK in metabolic disease'. American Journal of Physiology- Endochrinology and Metabolism, 296 (5):E969-E972. [DOI] [Details]
 

Conference Publications

Moran, C., Moran, A., di Palumbo, A., Egan, B., et al. (2014) Exploring the impact of a six-month multi-ingredient nutritional supplement on cognition in Irish older adults: A randomised controlled trial . In: Guerin, S eds. 44th Annual Conference, The Psychological Society of Ireland Newpark Hotel, Kilkenny, , 15-NOV-14 - 15-NOV-14 , pp.S28-S28 [Details]
Úbeda N, O'Gorman D, Egan B, Carson B, Peñalvo JL, García-Rovés P, Partearroyo T, Iglesias-Gutiérrez E; (2009) Homocysteine kinetics in response to exercise at different intensities and muscle contraction frequencies in young male sedentary individuals 7th International Conference on Homocysteine Metabolism [Details]
Egan B, Sarsfield FM, Carson BP, Garcia-Roves PM, Chibalin AV, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ ; (2008) Acute exercise increases expression of the transcription factor co-regulators PGC-1α and RIP140: Implications for the regulation of gene expression Keystone Symposia: Diabetes Mellitus, Insulin Action and Resistance [Details]
Carson BP, Egan B, Garcia-Roves PM, Sarsfield FM, Chibalin AV, Monedero J, O'Connor P, Moyna NM, McCaffrey N, Zierath JR, O'Gorman DJ ; (2007) Acute exercise and Akt signalling in human skeletal muscle: effect of exercise intensity Xth International Symposium on Insulin Receptors and Insulin Action [Details]
Egan B, Ashley DT, Kennedy E, O'Connor P, Monedero J, Sarsfield FM, Moyna NM, O'Gorman DJ ; (2006) Metabolic responses to acute exercise at two different exercise intensities during rowing and cycling ergometry Medicine & Science in Sports & Exercise 38(5S):S545 [Details]
Sarsfield FM, Egan B, O'Connor P, O'Brien K, Moyna NM, McCaffrey N, O'Gorman DJ ; (2006) The impact of carbohydrate ingestion on the regulation of fat oxidation after exercise Medicine & Science in Sports & Exercise 38(5S):S542 [Details]
Ashley DT, Egan B, Kennedy E, O'Connor P, Monedero J, Sarsfield FM, Moyna NM, O'Gorman DJ ; (2006) Fat oxidation rates are higher over a wide range of intensities during rowing compared to cycling ergometry Medicine & Science in Sports & Exercise 38(5S):S543 [Details]
Egan B, Jakeman PM; (2005) Influence of long-term physical activity and short-term exercise training on circulating insulin-like growth factor I and its binding proteins Medicine & Science in Sports & Exercise 37(5S):S239 [Details]
Jensen RL, Begg BJ, Butler PG, Egan B, Fitzgerald LE, Keane SC; (2004) Effects of static stretching on maximal isokinetic torque . In: Lamontagne M, Robertson DGE, Sveistrup H eds. Proceedings of the XXII International Symposium of Biomechanics in Sports , pp.51-53 [Details]
Jing M, Egan B, Kirwan JP ; (2003) Pregnancy induces greater insulin resistance and placental TNFα mRNA expression in mice with gestational diabetes mellitus Diabetes 52(S1):A407-8 [Details]
                                                     

Monographs:- Non Peer Reviewed

Egan, B; Newsholme P (2012) Starting blocks: The biochemical basis of contraction-induced signal transduction in skeletal muscle. Monographs:- Non Peer Reviewed Available Online [Details]
                                 

Research

Research Interests


Skeletal muscle metabolism and adaptation in exercise, health and disease


My research revolves around the molecular mechanisms governing adaptation in skeletal muscle, and the central role of muscle in whole body metabolism. As the largest organ in the body, skeletal muscle typically accounts for ~40% of total body mass, and is a major player in energy balance at rest by contributing ~30% of the resting metabolic rate in adults. Skeletal muscle has a critical role in glycemic control and metabolic homeostasis by virtue of being the predominant site of glucose disposal under insulin-stimulated conditions. Importantly, insulin resistance at the level of skeletal muscle is the primary defect in type 2 diabetes mellitus (T2DM), and linked to myriad of lifestyle-related chronic disease. My work examines the molecular mechanisms that underpin adaptation to exercise in health and disease, and the essential role of treatment of metabolic disease to which physical inactivity contributes.

Recent contributions have described the continuity from signals activated by acute exercise towards transcriptional and translational processes responsible for adaptation to repeated exercise (i.e. training) in skeletal muscle. These signals include phosphorylation, acetylation and DNA hypomethylation events induced by exercise within contracting skeletal muscle. From a translational perspective, my interest focuses on the ability of the intensity or mode (e.g. resistance vs. endurance) of exercise to modulate these events in the context of healthy or diseased muscle (i.e. T2DM, sarcopenia), with a view optimising exercise prescription through targeted exercise interventions. In essence, using exercise as personalised medicine.

Applied sports science and nutrition

My interest in applied sports science centres on nutrition and training interventions to optimise athletic performance, and in particular in team sports with high intensity, repeated sprint demands. Current projects include investigating the effect of resisted sled sprinting and nutrition supplementation, including beetroot juice and caffeinated chewing gum, on repeated sprint performance in team sport athletes. 

Research Projects

Sponsor : Irish Research Council (IRC)
Title : Microencapsulation of resveratrol to enhance bioavailability: therapeutic application in exercise and metabolic disease
Start Date / End Date : 01-OCT-14 / 30-SEP-18
Sponsor : Irish Research Council (IRC)
Title : Optimization of lifestyle intervention in older adults at risk for age-related functional (physical and cognitive) decline
Start Date / End Date : 01-FEB-15 / 31-JAN-18
Sponsor : Enterprise Ireland (EI)
Nuritas Ltd
Title : Screening protein samples for bioactivity in inflammation and muscle metabolism
Start Date / End Date : 04-JUN-13 / 30-APR-15
Sponsor : Food for Health Ireland - FHI2 UCD
Title : FHI-2 Glycaemic
Start Date / End Date : 02-SEP-13 / 02-SEP-18
Sponsor : Smartfish AS
Title : Multi-ingredient nutrition supplement for healthy ageing
Start Date / End Date : 01-AUG-13 / 31-JAN-15
Sponsor : Dairy Crest Group plc
Title : Nutrition formulation for healthy aging
Start Date / End Date : 13-MAY-13 / 12-NOV-13
Sponsor : University College Dublin (UCD)
Title : Exploring the exercise-induced secretome and its role in metabolic homeostasis using an in vitro model of muscle contraction
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : University College Dublin (UCD)
Title : Investigation of the exercise-induced secretome from human skeletal muscle and its role in metabolic homeostasis and exercise adaptation
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : University College Dublin (UCD)
Title : Utility of a desktop-based application to reduce time spent sitting and improve workplace health: a pilot study
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : Enterprise Ireland (EI)
Title : Glycemic index of commercially-available sugar substitutes and nutrition supplements.
Start Date / End Date : 29-NOV-12 / 29-NOV-13
 

Current Postgraduate Students

Michelle Hone, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Peter Horgan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Karl Cogan, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor
James Timmons, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Marcus Shortall, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201400   SMGT30240     Sports Management: Principles of Exercise Mgt
201400   SMGT30040     Sports Management: Illness and Injury in Sport
201400   SMGT10210     Sports Management: Appl Biology of Sport and Ex
201400   PERS40010     Performance Science: Ex Physiol & Sports Nutr
201400   PERS30020     Performance Science: Molecular Exercise Science
201400   PERS30010     Performance Science: Appl Nutr Health Ex & Sp Perf
201400   PERS20020     Performance Science: Intro Nutrit Hlth Exer&SportPf
201400   SMGT20180     Sports Management: Princp of Exercise Prescriptio
201400   SMGT30170     Sports Management: Applied Exercise Management
201400   PERS40080     Performance Science: Coach & Exerc Sci Diss
       

Collaborators

Internal Collaborators

Prof. Giuseppe De Vito, School of Public Health, Physiotherapy and Population Science

Prof. Philip Newsholme, School of Biomolecular & Biomedical Science

Prof. Helen M. Roche, Conway Institute of Biomolecular & Biomedical Research

External Collaborators

Prof. Juleen R. Zierath, Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Dr. Donal J. O'Gorman, Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Ireland