Navigation

Researchers at UCD

researcher

Desmond Fitzgerald

College Principal

Research Administration
UCD Research Building
Belfield
Dublin 4

Tel: +353 1 7164031
Email: des.fitzgerald@ucd.ie

Biography

2004- Present Professor of Molecular Medicine, University College Dublin
2003- 2004  Director of the Institute of Biopharmaceutical Sciences Royal College of Surgeons in Ireland.
1996- Adjunct Professor of Medicine and Pharmacology, University of Pennsylvania.
1994-2004  Professor of Clinical Pharmacology Royal College of Surgeons in Ireland.
1991-1994 Consultant Lecturer in Medicine,University College Dublin
1989-1991 Associate Professor in Medicine and Pharmacology, Vanderbilt University, Nashville

Publications

     

Peer Reviewed Journals

McCarthy C, Duffy MM, Mooney D, James WG, Griffin MD, Fitzgerald DJ, Belton O (2013) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. FASEB Journal, 27 (2):499-510. [DOI] [Details]
Marcone S, Fitzgerald DJ (2013) 'Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2'. Proteomics, 13 (14):2135-2139. [DOI] [Details]
McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass CK, Fitzgerald DJ, Belton O (2013) 'Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid'. EMBO molecular medicine, 5 (9):1443-1457. [DOI] [Details]
McClelland, S,Cox, C,O'Connor, R,de Gaetano, M,McCarthy, C,Cryan, L,Fitzgerald, D,Belton, O; (2010) 'Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell'. Atherosclerosis, 211 :96-102. [DOI] [Details]
Wiviott, SD,Flather, MD,O'Donoghue, ML,Goto, S,Fitzgerald, DJ,Cura, F,Aylward, P,Guetta, V,Dudek, D,Contant, CF,Angiolillo, DJ,Bhatt, DL,LANCELOT-CAD Investigators; (2011) 'Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease The Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease Trial'. Circulation, 123 . [DOI] [Details]
O'Donoghue, ML,Bhatt, DL,Wiviott, SD,Goodman, SG,Fitzgerald, DJ,Angiolillo, DJ,Goto, S,Montalescot, G,Zeymer, U,Aylward, PE,Guetta, V,Dudek, D,Ziecina, R,Contant, CF,Flather, MD,LANCELOT-ACS Investigators; (2011) 'Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes The Lessons From Antagonizing the Cellular Effects of Thrombin-Acute Coronary Syndromes Trial'. Circulation, 123 . [DOI] [Details]
O'Connor, R,Cryan, LM,Wynne, K,de Stefani, A,Fitzgerald, D,O'Brien, C,Cagney, G; (2010) 'Proteomics Strategy for Identifying Candidate Bioactive Proteins in Complex Mixtures: Application to the Platelet Releasate'. Journal Of Biomedicine And Biotechnology, . [DOI] [Details]
Maree, AO,Vangjeli, C,Jneid, H,Ryan, J,Cox, D,Cannon, CP,Shields, DC,Fitzgerald, DJ; (2010) 'G-protein beta 3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial'. Journal of Thrombosis and Haemostasis, 8 :934-941. [DOI] [Details]
McCarthy C, O'Gaora P, James WG, McClelland S, Fitzgerald DJ, Belton O; (2010) 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration'. Atherosclerosis, . [DOI] [Details]
Fitzgerald DJ, Doherty GA, Byrne SM, Austin SC, Scully GM, Sadlier DM, Neilan TG, Kay EW, Murray FE, ; (2009) 'Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer'. Cancer, 101 (3):483-491. [DOI] [Details]
Fitzgerald DJ, Doherty GA, Byrne SM, Molloy ES, Malhotra V, Austin SC, Kay EW, Murray FE, ; (2009) 'Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer'. BMC Cancer, 9 . [DOI] [Details]
McClelland, S,Gawaz, M,Kennerknecht, E,Konrad, CSI,Sauer, S,Schuerzinger, K,Massberg, S,Fitzgerald, DJ,Belton, O; (2009) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, 202 (NA):84-91. [DOI] [Details]
Steele, BM,Harper, MT,Macaulay, IC,Morrell, CN,Perez-Tamayo, A,Foy, M,Habas, R,Poole, AW,Fitzgerald, DJ,Maguire, PB; (2009) 'Canonical Wnt signaling negatively regulates platelet function'. Proceedings of the National Academy of Sciences of the United States of America, 106 (NA):19836-19841. [DOI] [Details]
Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, ; (2008) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, . [DOI] [Details]
O'Brien C, Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, ; (2008) 'Expression of COX-2 and prognostic outcome in uveal melanoma'. Eye, 33 (2):177-184. [DOI] [Details]
McCarthy GM, Molloy ES, Morgan MP, Doherty GA, McDonnell B, Hilliard M, O'Byrne J, Fitzgerald DJ, ; (2008) 'Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts'. Rheumatology, . [DOI] [Details]
Rajakariarl, R., Lawrence, T., Bystrom, J., Hilliard, M., Colville-Nash, P., Bellingan, G., Fitzgerald, D., Yaqoob, M. M., Gilroy, D. W., ; (2008) 'Novel biphasic role for lymphocytes revealed during resolving inflammation'. Blood, 111 (8):4184-4192. [Details]
Cathcart, M. C., Tamosiuniene, R., Chen, G., Neilan, T. G., Bradford, A., O'Byrne, K. J., Fitzgerald, D. J., Pidgeon, G. P., ; (2008) 'Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis'. Journal of Pharmacology and Experimental Therapeutics, 326 (1):51-58. [Details]
Coppinger, J., Fitzgerald, D. J., Maguire, P. B.; (2007) 'Isolation of the platelet releasate'. Methods in Molecular Biology, 357 :307-11. [Details]
Coppinger, J. A., O'Connor R, I., Wynne, K., Flanagan, M., Sullivan, M., Maguire, P. B., Fitzgerald, D. J., Cagney, G.; (2007) 'Moderation of the platelet releasate response by aspirin'. Blood, . [Details]
Maree, A. O., Fitzgerald, D. J.; (2007) 'Variable platelet response to aspirin and clopidogrel in atherothrombotic disease'. Circulation, 115 (16):2196-207. [Details]
Maree, A. O., Cox, D., Fitzgerald, D. J.; (2007) 'Drug insight: aspirin resistance-fact or fashion?'. Nat Clin Pract Cardiovasc Med, 4 (3). [Details]
Ahrens, IG; Moran, N; Aylward, K; Meade, G; Moser, M; Assefa, D; Fitzgerald, DJ; Bode, C; Peter, K; ; (2006) 'Evidence for a differential functional regulation of the two beta 3-integrins alpha(v)beta(3) and alpha(IIb)beta(3)'. Experimental Cell Research, 312 (6):925-937. [Details]
Cryan, L.M., Pidgeon, G.P., Fitzgerald, D.J., O'Brien, C.J.; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. MOLECULAR VISION, . [Details]
Kelly, P., Maguire, P.B., Bennett, M., Fitzgerald, D.J., Edwards, R.J., Thiede, B., Treumann, A., Collins, J.K., O'Sullivan, G.C., Shanahan, F., Dunne, C.; (2006) 'Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome'. FEMS MICROBIOLOGY LETTERS, . [Details]
O'Halloran, A.M., Curtin, R., O'Connor, F., Dooley, M., Fitzgerald, A., O'Brien, J.K., Fitzgerald, D.J. Shields, D.C.; (2006) 'The impact of genetic variation in the region of the GPIIIa gene, on PlA2 expression bias and GPIIb/IIIa receptor density in platelets'. BRITISH JOURNAL OF HAEMATOLOGY, . [Details]
Neilan, TG; Jassal, DS; Scully, MF; Chen, G; Deflandre, C; McAllister, H; Kay, E; Austin, SC; Halpern, EF; Harmey, JH; Fitzgerald, DJ; ; (2006) 'Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression'. European Heart Journal, 27 (10):1251-1256. [Details]
Maree, A. O., Jneid, H., Fitzgerald, D. J.; (2006) 'Aspirin resistance and atherothrombotic disease'. J Am Coll Cardiol, 48 (4):846-7; author. [Details]
Gottesman, S.,McCullen, C. A.,Guillier, M.,Vanderpool, C. K.,Majdalani, N.,Benhammou, J.,Thompson, K. M.,Fitzgerald, P. C.,Sowa, N. A.,Fitzgerald, D. J.; (2006) 'Small RNA Regulators and the Bacterial Response to Stress'. Cold Spring Harb Symp Quant Biol, 71 :1-11. [Details]
O'Halloran, A. M.,Curtin, R.,O'Connor, F.,Dooley, M.,Fitzgerald, A.,O'Brien, J. K.,Fitzgerald, D. J.,Shields, D. C.; (2006) 'The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets'. British Journal of Haematology, 132 (4):494-502. Available Online [Details]
Chubb AJ, Fitzgerald DJ, Nolan KB, Moman E; (2006) 'The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies'. Chemistry (Weinheim an der Bergstrasse, Germany), 45 (3):811-820. [DOI] [Details]
Ahrens, I. G., Moran, N., Aylward, K., Meade, G., Moser, M., Assefa, D., Fitzgerald, D. J., Bode, C., Peter, K.; (2006) 'Evidence for a differential functional regulation of the two beta(3)-integrins alpha(V)beta(3) and alpha(IIb)beta(3)'. Experimental Cell Research, 312 (6):925-37. [Details]
Chubb, A. J., Fitzgerald, D. J., Nolan, K. B., Moman, E.; (2006) 'The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies'. Biochemistry, 45 (3):811-20. [Details]
Cox, D., Maree, A. O., Dooley, M., Conroy, R., Byrne, M. F., Fitzgerald, D. J.; (2006) 'Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers'. Stroke, 37 (8):2153-8. [Details]
Cryan, L. M., Pidgeon, G. P., Fitzgerald, D. J., O'Brien, C. J.; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. Molecular Vision, 12 :405-14. [Details]
Pastan, I., Hassan, R., Fitzgerald, D. J., Kreitman, R. J.; (2006) 'Immunotoxin therapy of cancer'. Nat Rev Cancer, 6 (7):559-65. [Details]
Pastrana, D. V.,FitzGerald, D. J.; (2006) 'A nonradioactive, cell-free method for measuring protein synthesis inhibition by Pseudomonas exotoxin'. Annals of Biochemistry, 353 (2):266-71. [Details]
Onda, M., Nagata, S., FitzGerald, D. J., Beers, R., Fisher, R. J., Vincent, J. J., Lee, B., Nakamura, M., Hwang, J., Kreitman, R. J., Hassan, R., Pastan, I.; (2006) 'Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients'. Journal of Immunology, 177 (12):8822-34. [Details]
Neilan, T. G.,Doherty, G. A.,Chen, G.,Deflandre, C.,McAllister, H.,Butler, R. K.,McClelland, S. E.,Kay, E.,Ballou, L. R.,Fitzgerald, D. J.; (2006) 'Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin'. American Journal of Physiology-Heart and Circulatory Ph, 291 (2):H532-6. [Details]
Neilan, T. G., Jassal, D. S., Scully, M. F., Chen, G., Deflandre, C., McAllister, H., Kay, E., Austin, S. C., Halpern, E. F., Harmey, J. H., Fitzgerald, D. J.; (2006) 'Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression'. European Heart Journal, 27 (10):1251-6. [Details]
Haynes, L. P., Fitzgerald, D. J., Wareing, B., O'Callaghan, D. W., Morgan, A., Burgoyne, R. D.; (2006) 'Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta'. Proteomics, 6 (6):1822-32. [Details]
Fitzgerald, D. J., Berger, P., Schaffitzel, C., Yamada, K., Richmond, T. J., Berger, I.; (2006) 'Protein complex expression by using multigene baculoviral vectors'. Nat Methods, 3 (12):1021-32. [Details]
Neilan, TG; Doherty, GA; Chen, G; Deflandre, C; McAllister, H; Butler, RK; McClelland, SE; Kay, E; Ballou, LR; Fitzgerald, DJ; ; (2006) 'Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin'. American Journal of Physiology-Heart and Circulatory Physiology, 291 (2):532-536. [Details]
Neilan, TG; Fitzgerald, DJ; ; (2006) 'Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumor suppression: reply'. European Heart Journal, 27 (21):2611-2611. [Details]
Griffin, NM; Cagney, G; Sullivan, MJ; Cox, CM; Wynne, K; Fitzgerald, DJ; ; (2006) 'Regulation of protein expression by cyclooxygenase-2 in a human gastric cancer cell line'. Molecular & Cellular Proteomics, 5 (10):39-39. [Details]
Mager, DE; Shirey, JD; Cox, D; Fitzgerald, DJ; Abernethy, DR; ; (2005) 'Neural network model of orbofiban pharmacodynamics from sparse Phase-II data'. Clinical Pharmacology &Amp; Therapeutics, 77 (2):92-92. [Details]
Lee J, Chubb AJ, Moman E, McLoughlin BM, Sharkey CT, Kelly JG, Nolan KB, Devocelle M, Fitzgerald DJ; (2005) 'Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity'. Org Biomol Chem, 3 (20):3678-3685. [DOI] [Details]
Mager, DE; Shirey, JD; Cox, D; Fitzgerald, DJ; Abernethy, DR; ; (2005) 'Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network'. Journal of Pharmaceutical Sciences, 94 (11):2475-2486. [Details]
Fitzgerald, D. J., Stratford, M., Gasson, M. J., Narbad, A.; (2005) 'Structure-function analysis of the vanillin molecule and its antifungal properties'. J Agric Food Chem, 53 (5):1769-75. [Details]
Hasdemir, B.,Fitzgerald, D. J.,Prior, I. A.,Tepikin, A. V.,Burgoyne, R. D.; (2005) 'Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway'. J Cell Biol, 171 (3):459-69. [Details]
Hsieh, J. C.,Tham, D. M.,Feng, W.,Huang, F.,Embaie, S.,Liu, K.,Dean, D.,Hertle, R.,Fitzgerald, D. J.,Mrsny, R. J.; (2005) 'Intranasal immunization strategy to impede pilin-mediated binding of Pseudomonas aeruginosa to airway epithelial cells'. Infect Immun, 73 (11):7705-17. [Details]
Kelly, P.,Maguire, P. B.,Bennett, M.,Fitzgerald, D. J.,Edwards, R. J.,Thiede, B.,Treumann, A.,Collins, J. K.,O'Sullivan, G. C.,Shanahan, F.,Dunne, C.; (2005) 'Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome'. FEMS Microbiol Lett, 252 (1):153-9. [Details]
Kreitman, R. J.,Squires, D. R.,Stetler-Stevenson, M.,Noel, P.,FitzGerald, D. J.,Wilson, W. H.,Pastan, I.; (2005) 'Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies'. J Clin Oncol, 23 (27):6719-29. [Details]
Lee, J.,Chubb, A. J.,Moman, E.,McLoughlin, B. M.,Sharkey, C. T.,Kelly, J. G.,Nolan, K. B.,Devocelle, M.,Fitzgerald, D. J.; (2005) 'Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity'. Org Biomol Chem, 3 (20):3678-85. [Details]
Mager, D. E.,Shirey, J. D.,Cox, D.,Fitzgerald, D. J.,Abernethy, D. R.; (2005) 'Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network'. J Pharm Sci, 94 (11):2475-86. [Details]
Maguire, P. B., Foy, M., Fitzgerald, D. J.; (2005) 'Using proteomics to identify potential therapeutic targets in platelets'. Biochem Soc Trans, 33 (Pt 2):409-12. [Details]
Maree, A. O., Curtin, R. J., Chubb, A., Dolan, C., Cox, D., O'Brien, J., Crean, P., Shields, D. C., Fitzgerald, D. J.; (2005) 'Cyclooxygenase-1 haplotype modulates platelet response to aspirin'. Thrombosis and Haemostasis, 3 (10):2340-5. [Details]
Maree, A. O.,Curtin, R. J.,Dooley, M.,Conroy, R. M.,Crean, P.,Cox, D.,Fitzgerald, D. J.; (2005) 'Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease'. J Am Coll Cardiol, 46 (7):1258-63. [Details]
Pastrana, D. V.,Hanson, A. J.,Knisely, J.,Bu, G.,Fitzgerald, D. J.; (2005) 'LRP 1 B functions as a receptor for Pseudomonas exotoxin'. Biochim Biophys Acta, 1741 (3):234-9. [Details]
Macaulay, IC; Carr, P; Gusnanto, A; Ouwehand, WH; Fitzgerald, D; Watkins, NA; ; (2005) 'Platelet genomics and proteomics in human heat and disease'. Clinical Investigation, 115 (12):3370-3377. [Details]
Molloy, ES; Morgan, MP; Doherty, GA; O'Byrne, J; Fitzgerald, DJ; McCarthy, GM; ; (2005) 'Mechanism of basic calcium phosphate crystal-induced Upregulation of matrix metalloproteinase-13 in human osteoarthritic synovial fibroblasts: Effect of prostaglandin E2+'. Arthritis and Rheumatism, 52 (9):101-101. [Details]
Molloy, ES; Morgan, MP; Doherty, GA; O'Byrne, J; Fitzgerald, DJ; McCarthy, GM; ; (2005) 'Mechanism of cyclooxygenase induction by basic calcium phosphate crystals in osteoarthritic synovial fibroblasts'. Arthritis and Rheumatism, 52 (9):100-101. [Details]
Molloy, ES; Morgan, MP; Doherty, GA; O'Byrne, J; Fitzgerald, DJ; McCarthy, GM; ; (2005) 'Mechanism of cyclooxygenase induction by basic calcium phosphate crystals in osteoarthritic synovial fibroblasts'. Arthritis and Rheumatism, 52 (9):100-101. [Details]
Doherty, GA; Byrne, SM; Austin, SC; Scully, GM; Neilan, TG; Kay, EW; Murray, FE; Fitzgerald, DJ; ; (2005) 'A mechanism for cyclooxygenase-2 mediated regulation of apoptosis in colorectal cancer cells; The role of DRAK2, a death associated protein kinase'. Gut, 54 (NA):56-56. [Details]
Maree, A.O., Curtin, R.J., Chubb, A., Dolan, C., Cox, D., O'Brien, J., Crean, P., Shields, D.C., Fitzgerald, D.J.; (2005) 'Cyclooxygenase-1 haplotype modulates platelet response to aspirin'. THROMBOSIS AND HAEMOSTASIS, . [Details]
Maguire, FB; Foy, M; Fitzgerald, DJ; ; (2005) 'Using proteomics to identify potential therapeutic targets in platelets'. Biochemical Society Transactions, 33 (NA):409-412. [Details]
Cryan, LM; Pidgeon, GP; Fitzgerald, DJ; O' Brien, C; ; (2004) 'COX-2 has a protective role in a mouse model of ischaemic retinopathy'. Investigative Ophthalmology &Amp; Visual Science, 45 (NA):354-354. [Details]
McRedmond, J. P.,Park, S. D.,Reilly, D. F.,Coppinger, J. A.,Maguire, P. B.,Shields, D. C.,Fitzgerald, D. J.; (2004) 'Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes'. Mol Cell Proteomics, 3 (2):133-44. [Details]
McRedmond, JP; Mulvihill, NT; Kane, M; Burke, B; Aloul, B; Forde, T; Walsh, M; Fitzgerald, DJ; ; (2004) 'A rapid agglutination assay to detect anti-streptokinase antibodies'. Irish Journal of Medical Science, 173 (4):204-210. [Details]
Foy, M; Treumann, A; Fitzgerald, DJ; Maguire, PB; Kerrigan, SK; ; (2004) 'Characterization of platelet lipid rafts leads to the identification of RGS-19, which forms a phosphorylation-dependent complex with 14-3-3 xi'. Blood, 104 (11):181-181. [Details]
Maree, AO; Fitzgerald, DJ; ; (2004) 'Aspirin and coronary artery disease'. Journal of Thrombosis and Haemostasis, 92 (6):1175-1181. [Details]
Fitzgerald, D. J.,DeLuca, C.,Berger, I.,Gaillard, H.,Sigrist, R.,Schimmele, K.,Richmond, T. J.; (2004) 'Reaction cycle of the yeast Isw2 chromatin remodeling complex'. Embo J, 23 (19):3836-43. [Details]
FitzGerald, D. J.,Kreitman, R.,Wilson, W.,Squires, D.,Pastan, I.; (2004) 'Recombinant immunotoxins for treating cancer'. Int J Med Microbiol, 293 (7-8):577-82. [Details]
Fitzgerald, D. J.,Robinson, N. I.,Pester, B. A.; (2004) 'Application of benzo(a)pyrene and coal tar tumor dose-response data to a modified benchmark dose method of guideline development'. Environ Health Perspect, 112 (14):1341-6. [Details]
Fitzgerald, D. J.,Stratford, M.,Gasson, M. J.,Ueckert, J.,Bos, A.,Narbad, A.; (2004) 'Mode of antimicrobial action of vanillin against Escherichia coli, Lactobacillus plantarum and Listeria innocua'. J Appl Microbiol, 97 (1):104-13. [Details]
Fitzgerald, D. J.,Stratford, M.,Gasson, M. J.,Narbad, A.; (2004) 'The potential application of vanillin in preventing yeast spoilage of soft drinks and fruit juices'. J Food Prot, 67 (2):391-5. [Details]
Kearney, D.,Byrne, A.,Crean, P.,Cox, D.,Fitzgerald, D. J.; (2004) 'Optimal suppression of thromboxane A(2) formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase-2 inhibitor'. J Am Coll Cardiol, 43 (4):526-31. [Details]
Maree, A. O.,Fitzgerald, D. J.; (2004) 'Aspirin and coronary artery disease'. Thromb Haemost, 92 (6):1175-81. [Details]
McRedmond, J. P.,Mulvihill, N. T.,Kane, M.,Burke, B.,Aloul, B.,Forde, T.,Walsh, M.,Fitzgerald, D. J.; (2004) 'A rapid agglutination assay to detect anti-streptokinase antibodies'. Ir J Med Sci, 173 (4):204-10. [Details]
Maguire, P. B.,Moran, N.,Cagney, G.,Fitzgerald, D. J.; (2004) 'Application of proteomics to the study of platelet regulatory mechanisms'. Trends Cardiovasc Med, 14 (6):207-20. [Details]
Holden, NM; Fitzgerald, D; Ryan, D; Tierney, H; Murphy, F; ; (2004) 'Rainfall climate limitation to slurry spreading in Ireland'. Agricultural and Forest Meteorology, 122 (3-4):207-214. [Details]
Berger, I.,Fitzgerald, D. J.,Richmond, T. J.; (2004) 'Baculovirus expression system for heterologous multiprotein complexes'. Nat Biotechnol, 22 (12):1583-7. [Details]
Byrne, C. E.,Fitzgerald, A.,Cannon, C. P.,Fitzgerald, D. J.,Shields, D. C.; (2004) 'Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes'. BMC Med Genet, 5 . [Details]
Coppinger, J. A.,Cagney, G.,Toomey, S.,Kislinger, T.,Belton, O.,McRedmond, J. P.,Cahill, D. J.,Emili, A.,Fitzgerald, D. J.,Maguire, P. B.; (2004) 'Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions'. Blood, 103 (6):2096-104. [Details]
Wilderman, P. J.,Sowa, N. A.,FitzGerald, D. J.,FitzGerald, P. C.,Gottesman, S.,Ochsner, U. A.,Vasil, M. L.; (2004) 'Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis'. Proc Natl Acad Sci U S A, 101 (26):9792-7. [Details]
Urquidi-Macdonald, M.,Mager, D. E.,Mascelli, M. A.,Frederick, B.,Freedman, J.,Fitzgerald, D. J.,Kleiman, N. S.,Abernethy, D. R.; (2004) 'Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability'. Clin Pharmacol Ther, 75 (1):60-9. [Details]
Sheehan, K. M.,Cahill, R. A.,McGreal, G.,Steele, C.,Byrne, M. F.,Kirwan, W. O.,Kay, E. W.,Fitzgerald, D. J.,Redmond, H. P.,Murray, F. E.; (2004) 'Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases'. Dig Liver Dis, 36 (6):392-7. [Details]
Reilly, D.,Larkin, D.,Devocelle, M.,Fitzgerald, D. J.,Moran, N.; (2004) 'Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif'. Platelets, 15 (1):43-54. [Details]
Pidgeon, G. P.,Tamosiuniene, R.,Chen, G.,Leonard, I.,Belton, O.,Bradford, A.,Fitzgerald, D. J.; (2004) 'Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2'. Circulation, 110 (17):2701-7. [Details]
Olasupo, N. A.,Fitzgerald, D. J.,Narbad, A.,Gasson, M. J.; (2004) 'Inhibition of Bacillus subtilis and Listeria innocua by nisin in combination with some naturally occurring organic compounds'. J Food Prot, 67 (3):596-600. [Details]
Morgan, M. P.,Whelan, L. C.,Sallis, J. D.,McCarthy, C. J.,Fitzgerald, D. J.,McCarthy, G. M.; (2004) 'Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta'. Arthritis Rheum, 50 (5):1642-9. [Details]
Suyama, J.,Panagos, P. D.,Sztajnkrycer, M. D.,FitzGerald, D. J.,Barnes, D.; (2003) 'Injury patterns related to use of less-lethal weapons during a period of civil unrest'. J Emerg Med, 25 (2):219-27. [Details]
Maree, A.,Fitzgerald, D. J.; (2003) 'Glycoprotein IIb/IIIa antagonists in acute coronary syndromes: where are we now?'. Semin Vasc Med, 3 (4):385-90. [Details]
Shah, A. A.,Byrne, M. F.,Cullen, L.,Walsh, T.,Fitzgerald, D. J.,Murray, F. E.; (2003) 'Effect of H. pylori infection on the expression of cyclooxygenase-2 in human gastric mucosa'. Prostaglandins Leukot Essent Fatty Acids, 68 (1):1-8. [Details]
Olasupo, N. A.,Fitzgerald, D. J.,Gasson, M. J.,Narbad, A.; (2003) 'Activity of natural antimicrobial compounds against Escherichia coli and Salmonella enterica serovar Typhimurium'. Lett Appl Microbiol, 37 (6):448-51. [Details]
Murphy, J. F.,Steele, C.,Belton, O.,Fitzgerald, D. J.; (2003) 'Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphavbeta3'. Br J Haematol, 121 (1):157-64. [Details]
Mangas, S.,Fitzgerald, D. J.; (2003) 'Exposures to lead require ongoing vigilance'. Bull World Health Organ, 81 (11). [Details]
Cryan, LM; Fitzgerald, DJ; O'Brien, C; ; (2003) 'Isoform specific disruption of the cyclooxygenase genes in oxygen-induced retinopathy'. Investigative Ophthalmology &Amp; Visual Science, 44 (NA):77-77. [Details]
Devocelle, M.,McLoughlin, B. M.,Sharkey, C. T.,Fitzgerald, D. J.,Nolan, K. B.; (2003) 'A convenient parallel synthesis of low molecular weight hydroxamic acids using polymer-supported 1-hydroxybenzotriazole'. Org Biomol Chem, 1 (5):850-3. [Details]
Maguire, P. B.,Fitzgerald, D. J.; (2003) 'Platelet proteomics'. J Thromb Haemost, 1 (7):1593-601. [Details]
Mager, D. E.,Mascelli, M. A.,Kleiman, N. S.,Fitzgerald, D. J.,Abernethy, D. R.; (2003) 'Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty'. J Pharmacol Exp Ther, 307 (3):969-76. [Details]
Gaillard, H.,Fitzgerald, D. J.,Smith, C. L.,Peterson, C. L.,Richmond, T. J.,Thoma, F.; (2003) 'Chromatin remodeling activities act on UV-damaged nucleosomes and modulate DNA damage accessibility to photolyase'. J Biol Chem, 278 (20):17655-63. [Details]
FitzGerald, D. J.,Sztajnkrycer, M. D.,Crocco, T. J.; (2003) 'Chemical weapon functional exercise--Cincinnati: observations and lessons learned from a "typical medium-sized" city's response to simulated terrorism utilizing Weapons of Mass Destruction'. Public Health Rep, 118 (3):205-14. [Details]
Fitzgerald, D. J.,Stratford, M.,Narbad, A.; (2003) 'Analysis of the inhibition of food spoilage yeasts by vanillin'. Int J Food Microbiol, 86 (1-2):113-22. [Details]
Dooley, C. M.,Devocelle, M.,McLoughlin, B.,Nolan, K. B.,Fitzgerald, D. J.,Sharkey, C. T.; (2003) 'A novel family of hydroxamate-based acylating inhibitors of cyclooxygenase'. Mol Pharmacol, 63 (2):450-5. [Details]
Byrne, M. F.,Murphy, J. F.,Corcoran, P. A.,Atherton, J. C.,Sheehan, K. M.,Cox, D.,Murray, F. E.,Fitzgerald, D. J.; (2003) 'Helicobacter pylori induces cyclooxygenase-1 and cyclooxygenase-2 expression in vascular endothelial cells'. Scand J Gastroenterol, 38 (10):1023-30. [Details]
Byrne, M. F.,Kerrigan, S. W.,Corcoran, P. A.,Atherton, J. C.,Murray, F. E.,Fitzgerald, D. J.,Cox, D. M.; (2003) 'Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation'. Gastroenterology, 124 (7):1846-54. [Details]
Belton, O. A.,Duffy, A.,Toomey, S.,Fitzgerald, D. J.; (2003) 'Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis'. Circulation, 108 (24):3017-23. [Details]
Belton, O.,Fitzgerald, D. J.; (2003) 'Cyclooxygenase isoforms and atherosclerosis'. Expert Rev Mol Med, 2003 :1-18. [Details]
Tait, P. A.,Vora, A.,James, S.,Fitzgerald, D. J.,Pester, B. A.; (2002) 'Severe congenital lead poisoning in a preterm infant due to a herbal remedy'. Med J Aust, 177 (4):193-5. [Details]
Shields, D. C., Fitzgerald, A. P., O'Neill, P. A., Muckian, C., Kenny, D., Moran, B., Cannon, C. P., Byrne, C. E., Fitzgerald, D. J.; (2002) 'The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists'. Pharmacogenomics J, 2 (3):182-90. [Details]
Saka, E.,Iadarola, M.,Fitzgerald, D. J.,Graybiel, A. M.; (2002) 'Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation'. Proc Natl Acad Sci U S A, 99 (13):9004-9. [Details]
Quinn, M. J.,Fullard, J.,Kerrigan, S.,Harriott, P.,Cox, D.,Fitzgerald, D. J.; (2002) 'Characterization of a ligand-attenuated binding site on glycoprotein IIb/IIIa'. Thromb Haemost, 88 (5):811-6. [Details]
O'Brien, L., Kerrigan, S. W., Kaw, G., Hogan, M., Penades, J., Litt, D., Fitzgerald, D. J., Foster, T. J., Cox, D.; (2002) 'Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A'. Mol Microbiol, 44 (4):1033-44. [Details]
Byrne, M. F.,Corcoran, P. A.,Atherton, J. C.,Sheehan, K. M.,Murray, F. E.,Fitzgerald, D. J.,Murphy, J. F.; (2002) 'Stimulation of adhesion molecule expression by Helicobacter pylori and increased neutrophil adhesion to human umbilical vein endothelial cells'. FEBS Lett, 532 (3):411-4. [Details]
Curtin, R.,Fitzgerald, D. J.; (2002) 'Pharmacogenetics of antiplatelet drugs'. ScientificWorldJournal, 2 :791-800. [Details]
Muckian, C., Fitzgerald, A., O'Neill, A., O'Byrne, A., Fitzgerald, D. J., Shields, D. C.; (2002) 'Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease'. Blood, 100 (4):1220-3. [Details]
Mrsny, R. J.,Daugherty, A. L.,McKee, M. L.,FitzGerald, D. J.; (2002) 'Bacterial toxins as tools for mucosal vaccination'. Drug Discov Today, 7 (4):247-58. [Details]
McRedmond, J. P.,Fitzgerald, D. J.; (2002) 'A growing set of platelet-activating bacterial proteins'. Blood, 99 (1):387-8. [Details]
Maguire, P. B., Wynne, K. J., Harney, D. F., O'Donoghue, N. M., Stephens, G., Fitzgerald, D. J.; (2002) 'Identification of the phosphotyrosine proteome from thrombin activated platelets'. Proteomics, 2 (6):642-8. [Details]
Kenny, D.,Muckian, C.,Fitzgerald, D. J.,Cannon, C. P.,Shields, D. C.; (2002) 'Platelet glycoprotein Ib alpha receptor polymorphisms and recurrent ischaemic events in acute coronary syndrome patients'. J Thromb Thrombolysis, 13 (1):13-9. [Details]
Fitzgerald, D. J.,Cecere, G.; (2002) 'Hemofiltration and inflammatory mediators'. Perfusion, 17 Suppl :23-8. [Details]
Murphy, J. F.,Fitzgerald, D. J.; (2001) 'Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor'. Faseb J, 15 (9):1667-9. [Details]
O'Connor, F. F., Shields, D. C., Fitzgerald, A., Cannon, C. P., Braunwald, E., Fitzgerald, D. J.; (2001) 'Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes'. Blood, 98 (12):3256-60. [Details]
Obermoeller-McCormick, L. M.,Li, Y.,Osaka, H.,FitzGerald, D. J.,Schwartz, A. L.,Bu, G.; (2001) 'Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein'. J Cell Sci, 114 (Pt 5):899-908. [Details]
Laithwaite, J. E.,Benn, S. J.,Marshall, W. S.,FitzGerald, D. J.,LaMarre, J.; (2001) 'Divergent Pseudomonas exotoxin A sensitivity in normal and transformed liver cells is correlated with low-density lipoprotein receptor-related protein expression'. Toxicon, 39 (9):1283-90. [Details]
Hertle, R.,Mrsny, R.,Fitzgerald, D. J.; (2001) 'Dual-function vaccine for Pseudomonas aeruginosa: characterization of chimeric exotoxin A-pilin protein'. Infect Immun, 69 (11):6962-9. [Details]
Fitzgerald, D. J.; (2001) 'Vascular biology of thrombosis: the role of platelet-vessel wall adhesion'. Neurology, 57 (5 Suppl 2):S1-4. [Details]
Dekkers, R. J.,FitzGerald, D. J.,Couper, G. S.; (2001) 'Five-year clinical experience with Abiomed BVS 5000 as a ventricular assist device for cardiac failure'. Perfusion, 16 (1):13-8. [Details]
Dowd, N. P.,Scully, M.,Adderley, S. R.,Cunningham, A. J.,Fitzgerald, D. J.; (2001) 'Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo'. J Clin Invest, 108 (4):585-90. [Details]
Fullard, J., Murphy, R., O'Neill, S., Moran, N., Ottridge, B., Fitzgerald, D. J.; (2001) 'A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand'. Br J Haematol, 115 (1):131-9. [Details]
Kreitman, R. J.,Wilson, W. H.,Bergeron, K.,Raggio, M.,Stetler-Stevenson, M.,FitzGerald, D. J.,Pastan, I.; (2001) 'Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia'. N Engl J Med, 345 (4):241-7. [Details]
Loll, P. J., Sharkey, C. T., O'Connor, S. J., Dooley, C. M., O'Brien, E., Devocelle, M., Nolan, K. B., Selinsky, B. S., Fitzgerald, D. J.; (2001) 'O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions'. Mol Pharmacol, 60 (6):1407-13. [Details]
Shah, A. A.,Thjodleifsson, B.,Murray, F. E.,Kay, E.,Barry, M.,Sigthorsson, G.,Gudjonsson, H.,Oddsson, E.,Price, A. B.,Fitzgerald, D. J.,Bjarnason, I.; (2001) 'Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen'. Gut, 48 (3):339-46. [Details]
Quinn, M. J.,Murphy, R. T.,Dooley, M.,Foley, J. B.,Fitzgerald, D. J.; (2001) 'Occupancy of the internal and external pools of glycoprotein IIb/IIIa following abciximab bolus and infusion'. J Pharmacol Exp Ther, 297 (2):496-500. [Details]
Quinn, M. J.,Cox, D.,Foley, J. B.,Fitzgerald, D. J.; (2000) 'Glycoprotein IIb/IIIa receptor number and occupancy during chronic administration of an oral antagonist'. J Pharmacol Exp Ther, 295 (2):670-6. [Details]
O'Connor, F., Fitzgerald, D. J., Murphy, R. P.; (2000) 'An automated heteroduplex assay for the Pi(A) polymorphism of glycoprotein IIb/IIIa, multiplexed with two prothrombotic genetic markers'. Thromb Haemost, 83 (2):248-52. [Details]
Murphy, R. P., Donoghue, C., Nallen, R. J., D'Mello, M., Regan, C., Whitehead, A. S., Fitzgerald, D. J.; (2000) 'Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy'. Arterioscler Thromb Vasc Biol, 20 (1):266-70. [Details]
Adderley, S. R.,Fitzgerald, D. J.; (2000) 'Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation'. J Biol Chem, 275 (8):5760-6. [Details]
Belton, O.,Byrne, D.,Kearney, D.,Leahy, A.,Fitzgerald, D. J.; (2000) 'Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis'. Circulation, 102 (8):840-5. [Details]
Cox, D.,Smith, R.,Quinn, M.,Theroux, P.,Crean, P.,Fitzgerald, D. J.; (2000) 'Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes'. J Am Coll Cardiol, 36 (5):1514-9. [Details]
Curtin, R.,Fitzgerald, D. J.; (2000) 'A cold start for oral glycoprotein IIb/IIIa antagonists'. Eur Heart J, 21 (24):1992-4. [Details]
Daugherty, A. L.,McKee, M. L.,FitzGerald, D. J.,Mrsny, R. J.; (2000) 'Epithelial application of Pseudomonas aeruginosa exotoxin A results in a selective targeting to cells in the liver, spleen and lymph node'. J Control Release, 65 (1-2):297-302. [Details]
Moran, N.,Morateck, P. A.,Deering, A.,Ryan, M.,Montgomery, R. R.,Fitzgerald, D. J.,Kenny, D.; (2000) 'Surface expression of glycoprotein ib alpha is dependent on glycoprotein ib beta: evidence from a novel mutation causing Bernard-Soulier syndrome'. Blood, 96 (2):532-9. [Details]
McRedmond, J. P.,Harriott, P.,Walker, B.,Fitzgerald, D. J.; (2000) 'Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1'. Blood, 95 (4):1301-8. [Details]
Kreitman, R. J.,Margulies, I.,Stetler-Stevenson, M.,Wang, Q. C.,FitzGerald, D. J.,Pastan, I.; (2000) 'Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias'. Clin Cancer Res, 6 (4):1476-87. [Details]
O'Neill, S., Robinson, A., Deering, A., Ryan, M., Fitzgerald, D. J., Moran, N.; (2000) 'The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity'. J Biol Chem, 275 (47):36984-90. [Details]
Hillmann, A.,Shields, D. C.,Fitzgerald, D. J.,Kenny, D.; (2000) 'Polymorphisms in glycoprotein (GP) lb alpha are not associated with adverse outcomes in primigravidae'. J Obstet Gynaecol, 20 (3):250-5. [Details]
Sheehan, K. M.,Sheahan, K.,O'Donoghue, D. P.,MacSweeney, F.,Conroy, R. M.,Fitzgerald, D. J.,Murray, F. E.; (1999) 'The relationship between cyclooxygenase-2 expression and colorectal cancer'. Jama, 282 (13):1254-7. [Details]
Quinn, M. J.,Fitzgerald, D. J.; (1999) 'Ticlopidine and clopidogrel'. Circulation, 100 (15):1667-72. [Details]
Fitzgerald, D. J.; (1999) 'An international literature survey of "IARC Group 1 carcinogens'. Food Chem Toxicol, 37 (2-3):265-6. [Details]
McKee, M. L.,FitzGerald, D. J.; (1999) 'Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story'. Biochemistry, 38 (50):16507-13. [Details]
Kreitman, R. J.,Wang, Q. C.,FitzGerald, D. J.,Pastan, I.; (1999) 'Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys'. Int J Cancer, 81 (1):148-55. [Details]
Foster, C.,Fitzgerald, D. J.,Spatz, P.; (1999) 'Stability of the blood lactate-heart rate relationship in competitive athletes'. Med Sci Sports Exerc, 31 (4):578-82. [Details]
Fitzgerald, D. J.,Anderson, J. N.; (1999) 'DNA distortion as a factor in nucleosome positioning'. J Mol Biol, 293 (3):477-91. [Details]
Albert, F. G.,Eckdahl, T. T.,Fitzgerald, D. J.,Anderson, J. N.; (1999) 'Heterogeneity in the actions of drugs that bind in the DNA minor groove'. Biochemistry, 38 (31):10135-46. [Details]
Adderley, S. R.,Fitzgerald, D. J.; (1999) 'Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2'. J Biol Chem, 274 (8):5038-46. [Details]
Fitzgerald, D. J.,Anderson, J. N.; (1999) 'Selective nucleosome disruption by drugs that bind in the minor groove of DNA'. J Biol Chem, 274 (38):27128-38. [Details]
Foster, C.,Meyer, K.,Georgakopoulos, N.,Ellestad, A. J.,Fitzgerald, D. J.,Tilman, K.,Weinstein, H.,Young, H.,Roskamm, H.; (1999) 'Left ventricular function during interval and steady state exercise'. Med Sci Sports Exerc, 31 (8):1157-62. [Details]
Laithwaite, J. E.,Benn, S. J.,Yamate, J.,FitzGerald, D. J.,LaMarre, J.; (1999) 'Enhanced macrophage resistance to Pseudomonas exotoxin A is correlated with decreased expression of the low-density lipoprotein receptor-related protein'. Infect Immun, 67 (11):5827-33. [Details]
Mrsny, R. J.,Daugherty, A. L.,Fryling, C. M.,FitzGerald, D. J.; (1999) 'Mucosal administration of a chimera composed of Pseudomonas exotoxin and the gp120 V3 loop sequence of HIV-1 induces both salivary and serum antibody responses'. Vaccine, 17 (11-12):1425-33. [Details]
Fitzgerald, D. J.; (1999) 'Fibrinogen receptor and platelet signalling'. Blood Coagul Fibrinolysis, 10 Suppl 1 :S77-9. [Details]
Shah, A. A.,Fitzgerald, D. J.,Murray, F. E.; (1999) 'Non-steroidal anti-inflammatory drugs (NSAIDs) and gastro-intestinal toxicity: current issues'. Ir J Med Sci, 168 (4):242-5. [Details]
Shah, A. A.,Murray, F. E.,Fitzgerald, D. J.; (1999) 'The in vivo assessment of nimesulide cyclooxygenase-2 selectivity'. Rheumatology (Oxford), 38 Suppl 1 :19-23. [Details]
Schmoelzl, S.,Benn, S. J.,Laithwaite, J. E.,Greenwood, S. J.,Marshall, W. S.,Munday, N. A.,FitzGerald, D. J.,LaMarre, J.; (1998) 'Expression of hepatocyte low-density lipoprotein receptor-related protein is post-transcriptionally regulated by extracellular matrix'. Lab Invest, 78 (11):1405-13. [Details]
Palin, A. H.,Critcher, R.,Fitzgerald, D. J.,Anderson, J. N.,Farr, C. J.; (1998) 'Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility'. J Cell Sci, 111 ( Pt 12) :1623-34. [Details]
Murphy, N. P.,Pratico, D.,Fitzgerald, D. J.; (1998) 'Functional relevance of the expression of ligand-induced binding sites in the response to platelet GP IIb/IIIa antagonists in vivo'. J Pharmacol Exp Ther, 286 (2):945-51. [Details]
Ko, K. W.,McLeod, R. S.,Avramoglu, R. K.,Nimpf, J.,FitzGerald, D. J.,Vukmirica, J.,Yao, Z.; (1998) 'Mutation at the processing site of chicken low density lipoprotein receptor-related protein impairs efficient endoplasmic reticulum exit, but proteolytic cleavage is not essential for its endocytic functions'. J Biol Chem, 273 (43):27779-85. [Details]
Fitzgerald, D. J.,Anderson, J. N.; (1998) 'Unique translational positioning of nucleosomes on synthetic DNAs'. Nucleic Acids Res, 26 (11):2526-35. [Details]
Byrne, J. G.,Fitzgerald, D. J.,Aranki, S. F.; (1998) 'Simultaneous selective cerebral perfusion and systemic circulatory arrest through the right axillary artery for aortic surgery'. J Card Surg, 13 (4):236-8. [Details]
Cullen, L.,Kelly, L.,Connor, S. O.,Fitzgerald, D. J.; (1998) 'Selective cyclooxygenase-2 inhibition by nimesulide in man'. J Pharmacol Exp Ther, 287 (2):578-82. [Details]
FitzGerald, D. J.,Fryling, C. M.,McKee, M. L.,Vennari, J. C.,Wrin, T.,Cromwell, M. E.,Daugherty, A. L.,Mrsny, R. J.; (1998) 'Characterization of V3 loop-Pseudomonas exotoxin chimeras. Candidate vaccines for human immunodeficiency virus-1'. J Biol Chem, 273 (16):9951-8. [Details]
McMahon, G. P., O'Connor, S. J., Fitzgerald, D. J., le Roy, S., Kelly, M. T.; (1998) 'Determination of aspirin and salicylic acid in transdermal perfusates'. J Chromatogr B Biomed Sci Appl, 707 (1-2):322-7. [Details]
Rozemuller, H.,Terpstra, W.,Rombouts, E. J.,Lawler, M.,Byrne, C.,FitzGerald, D. J.,Kreitman, R. J.,Wielenga, J. J.,Lowenberg, B.,Touw, I. P.,Hagenbeek, A.,Martens, A. C.; (1998) 'GM-CSF receptor targeted treatment of primary AML in SCID mice using Diphtheria toxin fused to huGM-CSF'. Leukemia, 12 (12):1962-70. [Details]
Regan, C. L.,McAdam, B. F.,McParland, P.,Boylan, P. C.,FitzGerald, G. A.,Fitzgerald, D. J.; (1998) 'Reduced fetal exposure to aspirin using a novel controlled-release preparation in normotensive and hypertensive pregnancies'. Br J Obstet Gynaecol, 105 (7):732-8. [Details]
Rozemuller, H.,Rombouts, E. J.,Touw, I. P.,FitzGerald, D. J.,Kreitman, R. J.,Hagenbeek, A.,Martens, A. C.; (1998) 'In vivo targeting of leukemic cells using diphtheria toxin fused to murine GM-CSF'. Leukemia, 12 (5):710-7. [Details]
Quinn, M.,Fitzgerald, D. J.; (1998) 'Long-term administration of glycoprotein IIb/IIIa antagonists'. Am Heart J, 135 (5 Pt 2 Su):S113-8. [Details]
Fitzgerald, D. J.; (1998) 'Safety guidelines for copper in water'. Am J Clin Nutr, 67 (5 Suppl):1098S-1102S. [Details]
Terpstra, W.,Rozemuller, H.,Breems, D. A.,Rombouts, E. J.,Prins, A.,FitzGerald, D. J.,Kreitman, R. J.,Wielenga, J. J.,Ploemacher, R. E.,Lowenberg, B.,Hagenbeek, A.,Martens, A. C.; (1997) 'Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells'. Blood, 90 (9):3735-42. [Details]
Forde, R. C.,Fitzgerald, D. J.; (1997) 'Reactive oxygen species and platelet activation in reperfusion injury'. Circulation, 95 (4):787-9. [Details]
Fitzgerald, D. J.; (1997) 'Antitumor immunotoxin secretion by T cells: ABSolutely FABulous?'. Nat Biotechnol, 15 (1):18-9. [Details]
Byrne, A.,Moran, N.,Maher, M.,Walsh, N.,Crean, P.,Fitzgerald, D. J.; (1997) 'Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty'. Arterioscler Thromb Vasc Biol, 17 (11):3224-9. [Details]
Delanty, N.,Reilly, M. P.,Pratico, D.,Lawson, J. A.,McCarthy, J. F.,Wood, A. E.,Ohnishi, S. T.,Fitzgerald, D. J.,FitzGerald, G. A.; (1997) '8-epi PGF2 alpha generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo'. Circulation, 95 (11):2492-9. [Details]
Mansfield, E.,Amlot, P.,Pastan, I.,FitzGerald, D. J.; (1997) 'Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors'. Blood, 90 (5):2020-6. [Details]
Rozemuller, H.,Rombouts, E. J.,Touw, I. P.,FitzGerald, D. J.,Kreitman, R. J.,Pastan, I.,Hagenbeek, A.,Martens, A. C.; (1997) 'Sensitivity of human acute myeloid leukaemia to diphtheria toxin-GM-CSF fusion protein'. Br J Haematol, 98 (4):952-9. [Details]
Pratico, D.,Murphy, N. P.,Fitzgerald, D. J.; (1997) 'Interaction of a thrombin inhibitor and a platelet GP IIb/IIIa antagonist in vivo: evidence that thrombin mediates platelet aggregation and subsequent thromboxane A2 formation during coronary thrombolysis'. J Pharmacol Exp Ther, 281 (3):1178-85. [Details]
Mansfield, E.,Chiron, M. F.,Amlot, P.,Pastan, I.,FitzGerald, D. J.; (1997) 'Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells'. Biochem Soc Trans, 25 (2):709-14. [Details]
Fitzgerald, D. J.,Chaudhary, B. A.,Davis, W. B.; (1996) 'Eosinophilic pleural effusion: is it always nondiagnostic?'. J Fam Pract, 42 (4):405-7. [Details]
Gu, M.,Gordon, V. M.,Fitzgerald, D. J.,Leppla, S. H.; (1996) 'Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells'. Infect Immun, 64 (2):524-7. [Details]
Fitzgerald, D. J.,Bronson, E. C.,Anderson, J. N.; (1996) 'Compositional similarities between the human immunodeficiency virus and surface antigens of pathogens'. AIDS Res Hum Retroviruses, 12 (2):99-106. [Details]
Delanty, N.,Reilly, M.,Pratico, D.,FitzGerald, D. J.,Lawson, J. A.,FitzGerald, G. A.; (1996) '8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo'. Br J Clin Pharmacol, 42 (1):15-9. [Details]
Chiron, M. F.,Ogata, M.,FitzGerald, D. J.; (1996) 'Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin'. Mol Microbiol, 22 (4):769-78. [Details]
Delanty, N., Fitzgerald, D. J.; (1996) 'Paracetamol poisoning: the action line and the timing of acetylcysteine therapy'. Irish Medical Journal, 89 (5):156-158. [Details]
Fitzgerald, D. J.; (1996) 'Copper regulatory level in drinking-water as proposed by Sidhu et al'. Regul Toxicol Pharmacol, 23 (2):173-5. [Details]
Fitzgerald, D. J.,Speir, W. A.,Callahan, L. A.; (1996) 'Office evaluation of pulmonary function: beyond the numbers'. Am Fam Physician, 54 (2):525-34. [Details]
Mansfield, E.,Pastan, I.,FitzGerald, D. J.; (1996) 'Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies'. Bioconjug Chem, 7 (5):557-63. [Details]
Zdanovsky, A. G.,Zdanovskaia, M. V.,Strickland, D.,FitzGerald, D. J.; (1996) 'Ligand-toxin hybrids directed to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin'. J Biol Chem, 271 (11):6122-8. [Details]
Rozemuller, H.,Rombouts, W. J.,Touw, I. P.,FitzGerald, D. J.,Kreitman, R. J.,Pastan, I.,Hagenbeek, A.,Martens, A. C.; (1996) 'Treatment of acute myelocytic leukemia with interleukin-6 Pseudomonas exotoxin fusion protein in a rat leukemia model'. Leukemia, 10 (11):1796-803. [Details]
McAdam, B.,Keimowitz, R. M.,Maher, M.,Fitzgerald, D. J.; (1996) 'Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase'. J Pharmacol Exp Ther, 277 (2):559-64. [Details]
Stair, T. O.,Howell, J. M.,Fitzgerald, D. J.,Bailey, S. C.,Bastasch, M. D.; (1995) 'Hemolysis of blood specimens transported from ED to laboratory by pneumatic tube'. Am J Emerg Med, 13 (4). [Details]
Sasaki, K.,Bertrand, O.,Nakazawa, H.,Fitzgerald, D. J.,Mironov, N.,Yamasaki, H.; (1995) 'Cell-type-specific ras mutations but no microsatellite instability in chemically induced mouse skin tumors and transformed 3T3 cells'. Cancer Res, 55 (16):3513-6. [Details]
Pastan, I. H.,Pai, L. H.,Brinkmann, U.,Fitzgerald, D. J.; (1995) 'Recombinant toxins: new therapeutic agents for cancer'. Ann N Y Acad Sci, 758 :345-54. [Details]
Pitcher, C.,Roberts, L.,Fawell, S.,Zdanovsky, A. G.,FitzGerald, D. J.,Lord, J. M.; (1995) 'Generation of a potent chimeric toxin by replacement of domain III of Pseudomonas exotoxin with ricin A chain KDEL'. Bioconjug Chem, 6 (5):624-9. [Details]
Fitzgerald, D. J.,Milzman, D. P.,Sulmasy, D. P.; (1995) 'Creating a dignified option: ethical considerations in the formulation of prehospital DNR protocol'. Am J Emerg Med, 13 (2):223-8. [Details]
FitzGerald, D. J.,Fryling, C. M.,Zdanovsky, A.,Saelinger, C. B.,Kounnas, M.,Winkles, J. A.,Strickland, D.,Leppla, S.; (1995) 'Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein'. J Cell Biol, 129 (6):1533-41. [Details]
Fitzgerald, D. J.; (1995) 'Copper guideline values for drinking water: reviews in need of review?'. Regul Toxicol Pharmacol, 21 (1):177-9. [Details]
Fitzgerald, D. J.; (1995) 'Zinc and Alzheimer's disease'. Science, 268 (5219). [Details]
Dekkers, R. J.,Rizzo, R. J.,Body, S. C.,Fitzgerald, D. J.,Cohn, L. H.; (1995) 'Shed whole blood autotransfusion during aortic aneurysm operation with a modified collection infusion system'. Ann Thorac Surg, 59 (1):184-6. [Details]
Dekkers, R. J.,Rizzo, R. J.,Fitzgerald, D. J.,Cohn, L. H.; (1995) 'A modified collection and rapid infusion system for shed whole blood autotransfusion during aortic aneurysm surgery'. J Extra Corpor Technol, 27 (4):232-6. [Details]
Albert, F. G.,Bronson, E. C.,Fitzgerald, D. J.,Anderson, J. N.; (1995) 'Circular structures in retroviral and cellular genomes'. J Biol Chem, 270 (40):23570-81. [Details]
Wang, Q.,Albert, F. G.,Fitzgerald, D. J.,Calvo, J. M.,Anderson, J. N.; (1994) 'Sequence determinants of DNA bending in the ilvlH promoter and regulatory region of Escherichia coli'. Nucleic Acids Res, 22 (25):5753-60. [Details]
Kreitman, R. J.,Bailon, P.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1994) 'Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma'. Blood, 83 (2):426-34. [Details]
Keimowitz, R. M.,Fitzgerald, D. J.; (1994) 'Warfarin and aspirin after heart-valve replacement'. New England Journal of Medicine, 330 (7). [Details]
Fitzgerald, D. J.,Fusenig, N. E.,Boukamp, P.,Piccoli, C.,Mesnil, M.,Yamasaki, H.; (1994) 'Expression and function of connexin in normal and transformed human keratinocytes in culture'. Carcinogenesis, 15 (9):1859-65. [Details]
Fitzgerald, D. J.,Fryling, C. M.,Zdanovsky, A.,Saelinger, C. B.,Kounnas, M.,Strickland, D. K.,Leppla, S.; (1994) 'Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP'. Ann N Y Acad Sci, 737 :138-44. [Details]
Fitzgerald, D. J.,Dryden, G. L.,Bronson, E. C.,Williams, J. S.,Anderson, J. N.; (1994) 'Conserved patterns of bending in satellite and nucleosome positioning DNA'. J Biol Chem, 269 (33):21303-14. [Details]
DELANTY, N; REILLY, M; LAWSON, JA; FITZGERALD, DJ; FITZGERALD, GA; ; (1994) 'URINARY 8-EPI-PROSTAGLANDIN-F(2-ALPHA) EXCRETION AS A NONINVASIVE MARKER OF FREE-RADICAL INJURY IN HUMANS'. Clinical Research, 42 (2):182-182. [Details]
MODERNA, P; JENNINGS, L; FITZGERALD, DJ; ; (1994) 'DIFFERENCES BETWEEN PLATELET GPIIB/IIIA-FIBRIN AND GPIIB/IIIA-FIBRINOGEN INTERACTIONS IN-VITRO'. Clinical Research, 42 (2):131-131. [Details]
Chiron, M. F.,Fryling, C. M.,FitzGerald, D. J.; (1994) 'Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver'. J Biol Chem, 269 (27):18167-76. [Details]
Battey, F. D.,Gafvels, M. E.,FitzGerald, D. J.,Argraves, W. S.,Chappell, D. A.,Strauss, J. F., 3rd,Strickland, D. K.; (1994) 'The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor'. J Biol Chem, 269 (37):23268-73. [Details]
Zdanovsky, A. G.,Chiron, M.,Pastan, I.,FitzGerald, D. J.; (1993) 'Mechanism of action of Pseudomonas exotoxin. Identification of a rate-limiting step'. J Biol Chem, 268 (29):21791-9. [Details]
Wang, Q. C.,Pai, L. H.,Debinski, W.,FitzGerald, D. J.,Pastan, I.; (1993) 'Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin'. Cancer Res, 53 (19):4588-94. [Details]
Theuer, C. P.,FitzGerald, D. J.,Pastan, I.; (1993) 'A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer'. J Urol, 149 (6):1626-32. [Details]
Theuer, C. P.,Kreitman, R. J.,FitzGerald, D. J.,Pastan, I.; (1993) 'Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity'. Cancer Res, 53 (2):340-7. [Details]
Linnainmaa, K.,Pelin, K.,Vanhala, E.,Tuomi, T.,Piccoli, C.,Fitzgerald, D. J.,Yamasaki, H.; (1993) 'Gap junctional intercellular communication of primary and asbestos-associated malignant human mesothelial cells'. Carcinogenesis, 14 (8):1597-602. [Details]
Aranki, S. F.,Adams, D. H.,Rizzo, R. J.,Couper, G. S.,DeCamp, M. M.,Fitzgerald, D. J.,Cohn, L. H.; (1993) 'Femoral veno-arterial extracorporeal life support with minimal or no heparin'. Ann Thorac Surg, 56 (1):149-55. [Details]
Kreitman, R. J.,Hansen, H. J.,Jones, A. L.,FitzGerald, D. J.,Goldenberg, D. M.,Pastan, I.; (1993) 'Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab's; induce regression of subcutaneous human B-cell lymphoma in mice'. Cancer Res, 53 (4):819-25. [Details]
Fitzgerald, D. J.,Swierenga, S. H.,Mesnil, M.,Piccoli, C.,Marceau, N.,Yamasaki, H.; (1993) 'Gap junctional intercellular communication and connexin expression in normal and SV 40-transformed human liver cells in vitro'. Cancer Lett, 71 (1-3):157-65. [Details]
Kreitman, R. J.,Chaudhary, V. K.,Waldmann, T. A.,Hanchard, B.,Cranston, B.,FitzGerald, D. J.,Pastan, I.; (1993) 'Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia'. Leukemia, 7 (4):553-62. [Details]
Kreitman, R. J.,Batra, J. K.,Seetharam, S.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1993) 'Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds'. Bioconjug Chem, 4 (2):112-20. [Details]
Keimowitz, R. M.,Pulvermacher, G.,Mayo, G.,Fitzgerald, D. J.; (1993) 'Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin biosynthesis'. Circulation, 88 (2):556-61. [Details]
Prior, T. I.,FitzGerald, D. J.,Pastan, I.; (1992) 'Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol'. Biochemistry, 31 (14):3555-9. [Details]
Pastan, I.,Chaudhary, V.,FitzGerald, D. J.; (1992) 'Recombinant toxins as novel therapeutic agents'. Annu Rev Biochem, 61 :331-54. [Details]
Pai, L. H.,Batra, J. K.,FitzGerald, D. J.,Willingham, M. C.,Pastan, I.; (1992) 'Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys'. Cancer Res, 52 (11):3189-93. [Details]
Ogata, M.,Fryling, C. M.,Pastan, I.,FitzGerald, D. J.; (1992) 'Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol'. J Biol Chem, 267 (35):25396-401. [Details]
Kunitada, S.,FitzGerald, G. A.,Fitzgerald, D. J.; (1992) 'Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction'. Blood, 79 (6):1420-7. [Details]
Kreitman, R. J.,Siegall, C. B.,FitzGerald, D. J.,Epstein, J.,Barlogie, B.,Pastan, I.; (1992) 'Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma'. Blood, 79 (7):1775-80. [Details]
Kreitman, R. J.,Siegall, C. B.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1992) 'Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin'. Bioconjug Chem, 3 (1):63-8. [Details]
Kounnas, M. Z.,Morris, R. E.,Thompson, M. R.,FitzGerald, D. J.,Strickland, D. K.,Saelinger, C. B.; (1992) 'The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A'. J Biol Chem, 267 (18):12420-3. [Details]
Kreitman, R. J.,Schneider, W. P.,Queen, C.,Tsudo, M.,Fitzgerald, D. J.,Waldmann, T. A.,Pastan, I.; (1992) 'Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor'. J Immunol, 149 (8):2810-5. [Details]
Kreitman, R. J.,Chaudhary, V. K.,Siegall, C. B.,FitzGerald, D. J.,Pastan, I.; (1992) 'Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand'. Bioconjug Chem, 3 (1):58-62. [Details]
Kreitman, R. J.,Chaudhary, V. K.,Kozak, R. W.,FitzGerald, D. J.,Waldman, T. A.,Pastan, I.; (1992) 'Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia'. Blood, 80 (9):2344-52. [Details]
FitzGerald, D. J.,Pastan, I.; (1992) 'Pseudomonas exotoxin: recombinant conjugates as therapeutic agents'. Biochem Soc Trans, 20 (4):731-4. [Details]
Kerins, D. M.,Roy, L.,Kunitada, S.,Adedoyin, A.,FitzGerald, G. A.,Fitzgerald, D. J.; (1992) 'Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue'. Circulation, 85 (2):526-32. [Details]
Delanty, N.,Fitzgerald, D. J.; (1992) 'Subcutaneous heparin during coronary thrombolysis. Too little, too late'. Circulation, 86 (5):1636-8. [Details]
Brinkmann, U.,Pai, L. H.,FitzGerald, D. J.,Pastan, I.; (1992) 'Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice'. Proc Natl Acad Sci U S A, 89 (7):3065-9. [Details]
Athanasiou, K.,Constantopoulos, S. H.,Rivedal, E.,Fitzgerald, D. J.,Yamasaki, H.; (1992) 'Metsovo-tremolite asbestos fibres: in vitro effects on mutation, chromosome aberration, cell transformation and intercellular communication'. Mutagenesis, 7 (5):343-7. [Details]
Siegall, C. B.,Ogata, M.,Pastan, I.,FitzGerald, D. J.; (1991) 'Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation'. Biochemistry, 30 (29):7154-9. [Details]
Siegall, C. B.,Kreitman, R. J.,FitzGerald, D. J.,Pastan, I.; (1991) 'Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice'. Cancer Res, 51 (11):2831-6. [Details]
Siegall, C. B.,Epstein, S.,Speir, E.,Hla, T.,Forough, R.,Maciag, T.,Fitzgerald, D. J.,Pastan, I.; (1991) 'Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types'. Faseb J, 5 (13):2843-9. [Details]
Batra, J. K.,Fitzgerald, D. J.,Chaudhary, V. K.,Pastan, I.; (1991) 'Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv)'. Mol Cell Biol, 11 (4):2200-5. [Details]
Brinkmann, U.,Pai, L. H.,FitzGerald, D. J.,Willingham, M.,Pastan, I.; (1991) 'B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice'. Proc Natl Acad Sci U S A, 88 (19):8616-20. [Details]
Catella, F.,Lawson, J.,Braden, G.,Fitzgerald, D. J.,Shipp, E.,FitzGerald, G. A.; (1991) 'Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease'. Adv Prostaglandin Thromboxane Leukot Res, 21A :193-6. [Details]
Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1991) 'A proper amino terminus of diphtheria toxin is important for cytotoxicity'. Biochem Biophys Res Commun, 180 (2):545-51. [Details]
Prior, T. I.,Helman, L. J.,FitzGerald, D. J.,Pastan, I.; (1991) 'Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin'. Cancer Res, 51 (1):174-80. [Details]
Prior, T. I.,FitzGerald, D. J.,Pastan, I.; (1991) 'Barnase toxin: a new chimeric toxin composed of pseudomonas exotoxin A and barnase'. Cell, 64 (5):1017-23. [Details]
Pai, L. H.,Gallo, M. G.,FitzGerald, D. J.,Pastan, I.; (1991) 'Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40)'. Cancer Res, 51 (11):2808-12. [Details]
Pai, L. H.,Batra, J. K.,FitzGerald, D. J.,Willingham, M. C.,Pastan, I.; (1991) 'Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin'. Proc Natl Acad Sci U S A, 88 (8):3358-62. [Details]
Kerins, D. M.,Shuh, M.,Kunitada, S.,Fitzgerald, G. A.,Fitzgerald, D. J.; (1991) 'A prostacyclin analog impairs the response to tissue-type plasminogen activator during coronary thrombolysis: evidence for a pharmacokinetic interaction'. J Pharmacol Exp Ther, 257 (1):487-92. [Details]
Jongen, W. M.,Fitzgerald, D. J.,Asamoto, M.,Piccoli, C.,Slaga, T. J.,Gros, D.,Takeichi, M.,Yamasaki, H.; (1991) 'Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin'. J Cell Biol, 114 (3):545-55. [Details]
Heimbrook, D. C.,Stirdivant, S. M.,Ahern, J. D.,Balishin, N. L.,Patrick, D. R.,Edwards, G. M.,Defeo-Jones, D.,FitzGerald, D. J.,Pastan, I.,Oliff, A.; (1991) 'Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo'. J Ind Microbiol, 7 (3):203-7. [Details]
Furci, L.,Fitzgerald, D. J.,Fitzgerald, G. A.; (1991) 'Heterogeneity of prostaglandin H2/thromboxane A2 receptors: distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation'. J Pharmacol Exp Ther, 258 (1):74-81. [Details]
FitzGerald, G. A.,Murray, R.,Moran, N.,Funk, C.,Charman, W.,Clarke, R.,Furci, L.,Fitzgerald, D. J.; (1991) 'Mechanisms of eicosanoid action'. Adv Prostaglandin Thromboxane Leukot Res, 21B :577-81. [Details]
Fitzgerald, D. J.,Hanson, M.,FitzGerald, G. A.; (1991) 'Systemic lysis protects against the effects of platelet activation during coronary thrombolysis'. J Clin Invest, 88 (5):1589-95. [Details]
Fitzgerald, D. J.; (1991) 'Platelet activation in the pathogenesis of unstable angina: importance in determining the response to plasminogen activators'. Am J Cardiol, 68 (7):51B-57B. [Details]
Clarke, R. J.,Mayo, G.,FitzGerald, G. A.,Fitzgerald, D. J.; (1991) 'Combined administration of aspirin and a specific thrombin inhibitor in man'. Circulation, 83 (5):1510-8. [Details]
Tomasselli, A. G.,Hui, J. O.,Sawyer, T. K.,Staples, D. J.,FitzGerald, D. J.,Chaudhary, V. K.,Pastan, I.,Heinrikson, R. L.; (1990) 'Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease'. J Biol Chem, 265 (1):408-13. [Details]
Tomasselli, A. G.,Hui, J. O.,Sawyer, T. K.,Staples, D. J.,Bannow, C. A.,Reardon, I. M.,Chaudhary, V. K.,Fryling, C. M.,Pastan, I.,Fitzgerald, D. J.,et al.,; (1990) 'Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates'. J Virol, 64 (7):3157-61. [Details]
Takahara, K.,Murray, R.,FitzGerald, G. A.,Fitzgerald, D. J.; (1990) 'The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems'. J Biol Chem, 265 (12):6836-44. [Details]
Swierenga, S. H.,Yamasaki, H.,Piccoli, C.,Robertson, L.,Bourgon, L.,Marceau, N.,Fitzgerald, D. J.; (1990) 'Effects on intercellular communication in human keratinocytes and liver-derived cells of polychlorinated biphenyl congeners with differing in vivo promotion activities'. Carcinogenesis, 11 (6):921-6. [Details]
Siegall, C. B.,Schwab, G.,Nordan, R. P.,FitzGerald, D. J.,Pastan, I.; (1990) 'Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells'. Cancer Res, 50 (24):7786-8. [Details]
Siegall, C. B.,Nordan, R. P.,FitzGerald, D. J.,Pastan, I.; (1990) 'Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells'. Mol Cell Biol, 10 (6):2443-7. [Details]
Siegall, C. B.,FitzGerald, D. J.,Pastan, I.; (1990) 'Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin'. Curr Top Microbiol Immunol, 166 :63-9. [Details]
Siegall, C. B.,FitzGerald, D. J.,Pastan, I.; (1990) 'Cytotoxicity of IL6-PE40 and derivatives on tumor cells expressing a range of interleukin 6 receptor levels'. J Biol Chem, 265 (27):16318-23. [Details]
Siegall, C. B.,FitzGerald, D. J.,Pastan, I.; (1990) 'Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules'. Semin Cancer Biol, 1 (5):345-50. [Details]
Pai, L. H.,FitzGerald, D. J.,Tepper, M.,Schacter, B.,Spitalny, G.,Pastan, I.; (1990) 'Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice'. Cancer Res, 50 (24):7750-3. [Details]
Ogata, M.,Chaudhary, V. K.,Pastan, I.,FitzGerald, D. J.; (1990) 'Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol'. J Biol Chem, 265 (33):20678-85. [Details]
Lorberboum-Galski, H.,Garsia, R. J.,Gately, M.,Brown, P. S.,Clark, R. E.,Waldmann, T. A.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1990) 'IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes'. J Biol Chem, 265 (27):16311-7. [Details]
Kreitman, R. J.,Chaudhary, V. K.,Waldmann, T.,Willingham, M. C.,FitzGerald, D. J.,Pastan, I.; (1990) 'The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia'. Proc Natl Acad Sci U S A, 87 (21):8291-5. [Details]
Kozak, R. W.,Lorberboum-Galski, H.,Jones, L.,Puri, R. K.,Willingham, M. C.,Malek, T.,Fitzgerald, D. J.,Waldmann, T. A.,Pastan, I.; (1990) 'IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells'. J Immunol, 145 (8):2766-71. [Details]
Katoh, F.,Fitzgerald, D. J.,Giroldi, L.,Fujiki, H.,Sugimura, T.,Yamasaki, H.; (1990) 'Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro'. Jpn J Cancer Res, 81 (6-7):590-7. [Details]
Heimbrook, D. C.,Stirdivant, S. M.,Ahern, J. D.,Balishin, N. L.,Patrick, D. R.,Edwards, G. M.,Defeo-Jones, D.,FitzGerald, D. J.,Pastan, I.,Oliff, A.; (1990) 'Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts'. Proc Natl Acad Sci U S A, 87 (12):4697-701. [Details]
Fitzgerald, D. J.,Yamasaki, H.; (1990) 'Tumor promotion: models and assay systems'. Teratog Carcinog Mutagen, 10 (2):89-102. [Details]
Fitzgerald, D. J.,Rocki, W.,Murray, R.,Mayo, G.,FitzGerald, G. A.; (1990) 'Thromboxane A2 synthesis in pregnancy-induced hypertension'. Lancet, 335 (8692):751-4. [Details]
Chaudhary, V. K.,Gallo, M. G.,FitzGerald, D. J.,Pastan, I.; (1990) 'A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin'. Proc Natl Acad Sci U S A, 87 (23):9491-4. [Details]
Chaudhary, V. K.,Batra, J. K.,Gallo, M. G.,Willingham, M. C.,FitzGerald, D. J.,Pastan, I.; (1990) 'A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins'. Proc Natl Acad Sci U S A, 87 (3):1066-70. [Details]
Catella, F.,Lawson, J. A.,Fitzgerald, D. J.,FitzGerald, G. A.; (1990) 'Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension'. Proc Natl Acad Sci U S A, 87 (15):5893-7. [Details]
Braden, G. A.,Knapp, H. R.,Fitzgerald, D. J.,FitzGerald, G. A.; (1990) 'Dietary fish oil accelerates the response to coronary thrombolysis with tissue-type plasminogen activator. Evidence for a modest platelet inhibitory effect in vivo'. Circulation, 82 (1):178-87. [Details]
Berger, E. A.,Chaudhary, V. K.,Clouse, K. A.,Jaraquemada, D.,Nicholas, J. A.,Rubino, K. L.,Fitzgerald, D. J.,Pastan, I.,Moss, B.; (1990) 'Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions'. AIDS Res Hum Retroviruses, 6 (6):795-804. [Details]
Ashorn, P.,Moss, B.,Weinstein, J. N.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.,Berger, E. A.; (1990) 'Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors'. Proc Natl Acad Sci U S A, 87 (22):8889-93. [Details]
Siegall, C. B.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1989) 'Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin'. J Biol Chem, 264 (24):14256-61. [Details]
Ogata, M.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1989) 'Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin'. Proc Natl Acad Sci U S A, 86 (11):4215-9. [Details]
Pirker, R.,FitzGerald, D. J.,Raschack, M.,Frank, Z.,Willingham, M. C.,Pastan, I.; (1989) 'Enhancement of the activity of immunotoxins by analogues of verapamil'. Cancer Res, 49 (17):4791-5. [Details]
Pearson, J. W.,FitzGerald, D. J.,Willingham, M. C.,Wiltrout, R. H.,Pastan, I.,Longo, D. L.; (1989) 'Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice'. Cancer Res, 49 (13):3562-7. [Details]
O'Brien, E., Cox, J. P., Fitzgerald, D. J., O'Malley, K.; (1989) 'Discrepancy between clinic and ambulatory blood pressure measurement in the evaluation of two antihypertensive agents'. J Hum Hypertens, 3 (4):259-62. [Details]
Lorberboum-Galski, H.,Barrett, L. V.,Kirkman, R. L.,Ogata, M.,Willingham, M. C.,FitzGerald, D. J.,Pastan, I.; (1989) 'Cardiac allograft survival in mice treated with IL-2-PE40'. Proc Natl Acad Sci U S A, 86 (3):1008-12. [Details]
Klann, R. C.,Fitzgerald, D. J.,Piccoli, C.,Slaga, T. J.,Yamasaki, H.; (1989) 'Gap-junctional intercellular communication in epidermal cell lines from selected stages of SENCAR mouse skin carcinogenesis'. Cancer Res, 49 (3):699-705. [Details]
Kerins, D. M.,Roy, L.,FitzGerald, G. A.,Fitzgerald, D. J.; (1989) 'Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator'. Circulation, 80 (6):1718-25. [Details]
Fitzgerald, G. A.,Braden, G.,Fitzgerald, D. J.,Knapp, H. R.; (1989) 'Fish oils in cardiovascular disease'. J Intern Med Suppl, 731 :25-9. [Details]
Fitzgerald, D. J.,Wright, F.,FitzGerald, G. A.; (1989) 'Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo'. Circ Res, 65 (1):83-94. [Details]
Fitzgerald, D. J.,Piccoli, C.,Yamasaki, H.; (1989) 'Detection of non-genotoxic carcinogens in the BALB/c 3T3 cell transformation/mutation assay system'. Mutagenesis, 4 (4):286-91. [Details]
Fitzgerald, D. J.,Mesnil, M.,Oyamada, M.,Tsuda, H.,Ito, N.,Yamasaki, H.; (1989) 'Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis'. J Cell Biochem, 41 (2):97-102. [Details]
Fitzgerald, D. J.,Fitzgerald, G. A.; (1989) 'Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator'. Proc Natl Acad Sci U S A, 86 (19):7585-9. [Details]
Fitzgerald, D. J.; (1989) 'Platelet inhibition with an antibody to glycoprotein IIb/IIIa'. Circulation, 80 (6):1918-9. [Details]
Chaudhary, V. K.,Queen, C.,Junghans, R. P.,Waldmann, T. A.,FitzGerald, D. J.,Pastan, I.; (1989) 'A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin'. Nature, 339 (6223):394-7. [Details]
Berger, E. A.,Clouse, K. A.,Chaudhary, V. K.,Chakrabarti, S.,FitzGerald, D. J.,Pastan, I.,Moss, B.; (1989) 'CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses'. Proc Natl Acad Sci U S A, 86 (23):9539-43. [Details]
Batra, J. K.,Jinno, Y.,Chaudhary, V. K.,Kondo, T.,Willingham, M. C.,FitzGerald, D. J.,Pastan, I.; (1989) 'Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin'. Proc Natl Acad Sci U S A, 86 (21):8545-9. [Details]
Yamasaki, H.,Enomoto, K.,Fitzgerald, D. J.,Mesnil, M.,Katoh, F.,Hollstein, M.; (1988) 'Role of intercellular communication in the control of critical gene expression during multistage carcinogenesis'. IARC Sci Publ, (92):57-75. [Details]
Siegall, C. B.,Chaudhary, V. K.,FitzGerald, D. J.,Pastan, I.; (1988) 'Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells'. Proc Natl Acad Sci U S A, 85 (24):9738-42. [Details]
Pirker, R.,FitzGerald, D. J.,Willingham, M. C.,Pastan, I.; (1988) 'Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines'. Cancer Res, 48 (14):3919-23. [Details]
Oshimura, M.,Fitzgerald, D. J.,Kitamura, H.,Nettesheim, P.,Barrett, J. C.; (1988) 'Cytogenetic changes in rat tracheal epithelial cells during early stages of carcinogen-induced neoplastic progression'. Cancer Res, 48 (3):702-8. [Details]
Mesnil, M.,Fitzgerald, D. J.,Yamasaki, H.; (1988) 'Phenobarbital specifically reduces gap junction protein mRNA level in rat liver'. Mol Carcinog, 1 (2):79-81. [Details]
Lorberboum-Galski, H.,Kozak, R. W.,Waldmann, T. A.,Bailon, P.,FitzGerald, D. J.,Pastan, I.; (1988) 'Interleukin 2 (IL2) PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor'. J Biol Chem, 263 (35):18650-6. [Details]
Jinno, Y.,Chaudhary, V. K.,Kondo, T.,Adhya, S.,FitzGerald, D. J.,Pastan, I.; (1988) 'Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity'. J Biol Chem, 263 (26):13203-7. [Details]
Gallo, M. G.,Chaudhary, V. K.,Fitzgerald, D. J.,Willingham, M. C.,Pastan, I.; (1988) 'Cloning and expression of the H chain V region of antibody OVB3 that reacts with human ovarian cancer'. J Immunol, 141 (3):1034-40. [Details]
FitzGerald, D. J.,Willingham, M. C.,Pastan, I.; (1988) 'Pseudomonas exotoxin--immunotoxins'. Cancer Treat Res, 37 :161-73. [Details]
Fitzgerald, D. J.,Fragetta, J.,FitzGerald, G. A.; (1988) 'Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis'. J Clin Invest, 82 (5):1708-13. [Details]
Fitzgerald, D. J.,Catella, F.,Roy, L.,FitzGerald, G. A.; (1988) 'Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction'. Circulation, 77 (1):142-50. [Details]
Chaudhary, V. K.,Mizukami, T.,Fuerst, T. R.,FitzGerald, D. J.,Moss, B.,Pastan, I.,Berger, E. A.; (1988) 'Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein'. Nature, 335 (6188):369-72. [Details]
Willingham, M. C.,FitzGerald, D. J.,Pastan, I.; (1987) 'Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model'. Proc Natl Acad Sci U S A, 84 (8):2474-8. [Details]
Nettesheim, P.,Fitzgerald, D. J.,Kitamura, H.,Walker, C. L.,Gilmer, T. M.,Barrett, J. C.,Gray, T. E.; (1987) 'In vitro analysis of multistage carcinogenesis'. Environ Health Perspect, 75 :71-9. [Details]
Hwang, J.,Fitzgerald, D. J.,Adhya, S.,Pastan, I.; (1987) 'Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli'. Cell, 48 (1):129-36. [Details]
FitzGerald, G. A.,Fitzgerald, D. J.,Lawson, J. A.,Murray, R.; (1987) 'Thromboxane biosynthesis and antagonism in humans'. Adv Prostaglandin Thromboxane Leukot Res, 17A :199-203. [Details]
FitzGerald, D. J.,Willingham, M. C.,Cardarelli, C. O.,Hamada, H.,Tsuruo, T.,Gottesman, M. M.,Pastan, I.; (1987) 'A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells'. Proc Natl Acad Sci U S A, 84 (12):4288-92. [Details]
Griffin, T. W.,Childs, L. R.,FitzGerald, D. J.,Levin, L. V.; (1987) 'Enhancement of the cytotoxic effect of anti-carcinoembryonic antigen immunotoxins by adenovirus and carboxylic ionophores'. J Natl Cancer Inst, 79 (4):679-85. [Details]
Catella, F.,Lawson, J. A.,Fitzgerald, D. J.,FitzGerald, G. A.; (1987) 'Analysis of multiple thromboxane metabolites in plasma and urine'. Adv Prostaglandin Thromboxane Leukot Res, 17B :611-4. [Details]
Chaudhary, V. K.,FitzGerald, D. J.,Adhya, S.,Pastan, I.; (1987) 'Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin'. Proc Natl Acad Sci U S A, 84 (13):4538-42. [Details]
Cryz, S. J., Jr.,Furer, E.,Sadoff, J. C.,Germanier, R.,Pastan, I.,Willingham, M. C.,FitzGerald, D. J.; (1987) 'Use of Pseudomonas aeruginosa toxin A in the construction of conjugate vaccines and immunotoxins'. Rev Infect Dis, 9 Suppl 5 :S644-9. [Details]
FitzGerald, D. J.; (1987) 'Construction of immunotoxins using Pseudomonas exotoxin A'. Methods Enzymol, 151 :139-45. [Details]
FitzGerald, D. J.,Bjorn, M. J.,Ferris, R. J.,Winkelhake, J. L.,Frankel, A. E.,Hamilton, T. C.,Ozols, R. F.,Willingham, M. C.,Pastan, I.; (1987) 'Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer'. Cancer Res, 47 (5):1407-10. [Details]
Fitzgerald, D. J.,Mayo, G.,Catella, F.,Entman, S. S.,FitzGerald, G. A.; (1987) 'Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets'. Am J Obstet Gynecol, 157 (2):325-30. [Details]
Fitzgerald, D. J.,Fragetta, J.,Fenelon, L. C.,FitzGerald, G. A.; (1987) 'Thromboxane synthase inhibition and thromboxane/endoperoxide receptor antagonism in a chronic canine model of coronary thrombosis'. Adv Prostaglandin Thromboxane Leukot Res, 17A :496-500. [Details]
Fitzgerald, D. J.,Entman, S. S.,Mulloy, K.,FitzGerald, G. A.; (1987) 'Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension'. Circulation, 75 (5):956-63. [Details]
Pastan, I.,Willingham, M. C.,FitzGerald, D. J.; (1986) 'Immunotoxins'. Cell, 47 (5):641-8. [Details]
Fitzgerald, D. J.,Roy, L.,Catella, F.,FitzGerald, G. A.; (1986) 'Platelet activation in unstable coronary disease'. N Engl J Med, 315 (16):983-9. [Details]
Fitzgerald, D. J.,Kitamura, H.,Barrett, J. C.,Nettesheim, P.; (1986) 'Analysis of growth fractions and stem cell compartments in transformed rat tracheal epithelial cell colonies'. Cancer Res, 46 (9):4642-9. [Details]
Fitzgerald, D. J.,Barrett, J. C.,Nettesheim, P.; (1986) 'Changing responsiveness to all-trans retinoic acid of rat tracheal epithelial cells at different stages of neoplastic transformation'. Carcinogenesis, 7 (10):1715-21. [Details]
FitzGerald, D. J.,Willingham, M. C.,Pastan, I.; (1986) 'Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer'. Proc Natl Acad Sci U S A, 83 (17):6627-30. [Details]
Fitzgerald, D. J.,Doran, J.,Jackson, E.,FitzGerald, G. A.; (1986) 'Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo'. J Clin Invest, 77 (2):496-502. [Details]
Kitamura, H.,Fitzgerald, D. J.,Li, L. A.,Barrett, J. C.,Nettesheim, P.; (1986) 'Morphological characterization of transformed colonies in rat tracheal epithelial cell cultures exposed to carcinogen'. Cancer Res, 46 (9):4631-41. [Details]
Pirker, R.,FitzGerald, D. J.,Hamilton, T. C.,Ozols, R. F.,Willingham, M. C.,Pastan, I.; (1985) 'Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines'. Cancer Res, 45 (2):751-7. [Details]
Pirker, R.,FitzGerald, D. J.,Hamilton, T. C.,Ozols, R. F.,Laird, W.,Frankel, A. E.,Willingham, M. C.,Pastan, I.; (1985) 'Characterization of immunotoxins active against ovarian cancer cell lines'. J Clin Invest, 76 (3):1261-7. [Details]
Fitzgerald, D. J., O'Callaghan, W. G., O'Brien, E., Johnson, H., Mulcahy, R., Hickey, N.; (1985) 'Home recording of blood pressure in the management of hypertension'. Irish Medical Journal, 78 (8):216-8. [Details]
Seth, P.,Fitzgerald, D. J.,Willingham, M. C.,Pastan, I.; (1984) 'Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate'. J Virol, 51 (3):650-5. [Details]
FitzGerald, G. A.,Fitzgerald, D. J.; (1984) 'Biosynthesis of thromboxane A2 in renovascular hypertension'. Jama, 251 (23):3121-2. [Details]
FitzGerald, D. J.,Waldmann, T. A.,Willingham, M. C.,Pastan, I.; (1984) 'Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor'. J Clin Invest, 74 (3):966-71. [Details]
Fitzgerald, D. J.,Roy, L.,Robertson, R. M.,FitzGerald, G. A.; (1984) 'The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans'. Circulation, 70 (2):297-302. [Details]
Fitzgerald, D. J., O'Malley, K.; (1984) 'Plasma drug levels as an aid to medical treatment'. Irish Medical Journal, 77 (1):23-6. [Details]
Akiyama, S.,Gottesman, M. M.,Hanover, J. A.,Fitzgerald, D. J.,Willingham, M. C.,Pastan, I.; (1984) 'Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin'. J Cell Physiol, 120 (3):271-9. [Details]
O'Callaghan, W. G., Fitzgerald, D. J., O'Malley, K., O'Brien, E.; (1983) 'Accuracy of indirect blood pressure measurement in the elderly'. Br Med J (Clin Res Ed), 286 (6377):1545-6. [Details]
FitzGerald, D. J.,Trowbridge, I. S.,Pastan, I.,Willingham, M. C.; (1983) 'Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus'. Proc Natl Acad Sci U S A, 80 (13):4134-8. [Details]
Zoon, K. C.,Arnheiter, H.,Zur Nedden, D.,Fitzgerald, D. J.,Willingham, M. C.; (1983) 'Human interferon alpha enters cells by receptor-mediated endocytosis'. Virology, 130 (1):195-203. [Details]
Willingham, M. C.,Haigler, H. T.,Fitzgerald, D. J.,Gallo, M. G.,Rutherford, A. V.,Pastan, I. H.; (1983) 'The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling'. Exp Cell Res, 146 (1):163-75. [Details]
FitzGerald, D. J.,Padmanabhan, R.,Pastan, I.,Willingham, M. C.; (1983) 'Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis'. Cell, 32 (2):607-17. [Details]
Fitzgerald, D. J.,Knowles, S. E.,Ballard, F. J.,Murray, A. W.; (1983) 'Rapid and reversible inhibition of junctional communication by tumor promoters in a mouse cell line'. Cancer Res, 43 (8):3614-8. [Details]
Murray, A. W.,Fitzgerald, D. J.,Guy, G. R.; (1982) 'Inhibition of intercellular communication by tumor promoters'. Carcinog Compr Surv, 7 :587-91. [Details]
Fitzgerald, D. J., O'Malley, K., O'Brien, E. T.; (1982) 'Inaccuracy of London School of Hygiene sphygmomanometer'. Br Med J (Clin Res Ed), 284 (6308):18-9. [Details]
Fitzgerald, D. J., O'Callaghan, W. G., O'Malley, K., Horgan, J., O'Brien, E.; (1982) 'Clinical and haemodynamic responses to captopril and hydralazine in chronic congestive heart failure: the importance of preload reduction'. Br J Clin Pharmacol, 14 Suppl 2 :217S-222S. [Details]
Fitzgerald, D. J., O'Callaghan, W. G., McQuaid, R., O'Malley, K., O'Brien, E.; (1982) 'Accuracy and reliability of two indirect ambulatory blood pressure recorders: Remler M2000 and Cardiodyne Sphygmolog'. Br Heart J, 48 (6):572-9. [Details]
Fitzgerald, D. J.,Murray, A. W.; (1982) 'A new intercellular communication assay: its use in studies on the mechanism of tumour promotion'. Cell Biol Int Rep, 6 (3):235-42. [Details]
Burke, M. J., Towers, H. M., O'Malley, K., Fitzgerald, D. J., O'Brien, E. T.; (1982) 'Sphygmomanometers in hospital and family practice: problems and recommendations'. Br Med J (Clin Res Ed), 285 (6340):469-71. [Details]
Fitzgerald, D. J., O'Malley, K., O'Brien, E. T.; (1981) 'Assessing automated blood pressure recorders'. Lancet, 2 (8253). [Details]
Fitzgerald, D. J., O'Callaghan, W. G., O'Malley, K., O'Brien, E. T.; (1981) 'Accuracy of the London School of Hygiene and Remler M2000 sphygmomanometers'. Clin Sci (Lond), 61 Suppl 7 :399s-401s. [Details]
Fitzgerald, D. J.,Murray, A. W.; (1980) 'Inhibition of intercellular communication by tumor-promoting phorbol esters'. Cancer Res, 40 (8 Pt 1):2935-7. [Details]
Murray, A. W.,Fitzgerald, D. J.; (1979) 'Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells'. Biochem Biophys Res Commun, 91 (2):395-401. [Details]
Kailis, D. G.,Taylor, S. R.,Davis, G. B.,Bartlett, L. G.,Fitzgerald, D. J.,Grose, I. J.,Newton, P. D.; (1968) 'Fluoride and caries: observations on the effects of prenatal and postnatal fluoride on some Perth pre-school children'. Med J Aust, 2 (23):1037-40. [Details]

Other Journals

Toomey, S., Harhen,B., Roche, H.M., Fitzgerald, D., Belton, O.; (2006) 'Profound resolution of early atherosclerosis with conjugated linoleic acid' Atherosclerosis . [Details]

Conference Publications

Foody, J., Kelly, D., Kumar, D., Fitzgerald, D., Caulfield,B., Ward T. and Markham, C.; (2006) Prototype Sourceless Kinematic-Feedback Based Video Game for Movement Based Exercise International Conference of the Engineering in Medicine and Biology Conference (EMBC 2006) New York, USA, , 28-AUG-06 - 03-SEP-06 [Details]
Foody, J., Kelly, D., Kumar, D., Fitzgerald, D., Caulfield,B., Ward T. and Markham, M.; (2006) A Real Time Motion Capture System, Using USB Based Tri-Axis Magnetic and Inertial Sensors Irish Signals and Systems Conference Dublin, Ireland, , 28-JUN-06 - 30-JUN-06 [Details]
                                                                                         

Research

Research Interests

The two cyclooxygenases, COX-1 and COX-2, provide the first step in the generation of prostaglandins (PGs). Our molecular medicine unit has a number of ongoing projects that focus on novel aspects of COX biology.


Gene regulation by COX-2 in colon cancer
There has been sustained interest in the role of COX-2, which is over expressed in the majority of gastrointestinal tumours and whose level of expression predicts poor clinical outcomes. This project aims to identify genes that are responsive not alone to COX-2 inhibition, but overexpression of COX2. We have identified a set of COX-2 regulated genes and have proceeded to characterise the expression of two genes, ?-catenin and DRAK2, a novel serine-threonine kinase with putative pro-apoptotic effects. This project also investigates the expression of these genes in human tumour tissue. A role of DRAK2 in regulation of cell death in cancer has not been well characterised. Therefore, part of this project involves establishing a system to silence the expression of DRAK2 in using RNA interference.
This project has been extended with a proteomics component that explores the proteins that are regulated by COX-2 in gastric (AGS) and breast (MCF-7) cancer cell lines. The effect of over-expressing COX-2 on the protein population of these cells is examined using 2D gel electrophoresis. Thus far, a number of differentially expressed proteins are being characterised by mass spectrometry.
Regulation of doxorubicin-induced cardiotoxicity by prostaglandins
We have shown that COX-2 inhibition aggravates the cardiac injury seen with the chemotherapy drug, doxorubicin. Although we showed that PGI2 prevented this injury, one limitation to the use of exogenous PGI2 is that while protecting the heart, it may also protect the tumour, the intended target for doxorubicin. To address this we use a mouse tumour model, where Lewis lung tumour cells, injected subcutaneously develop into a solid tumour that is sensitive to doxorubicin. A second part of this project is to examine the effect of doxorubicin in the COX-2-/- mouse by examining fractional shortening by ECHO and intraaortic pressure readings. To complement this work, transgenic animals are being generated in collaboration with Professor Pete Humphries, TCD and Dr Sandra Austin, UCD to generate a cardiac specific COX-2 transgenic mouse.

The pathobiology of PGJ2
This project focuses on PGJ2, which is unique in being antiinflammatory and inducing apoptosis. PGJ2 and its analogues are derivatives of PGD2 that influence gene expression by acting as ligands for PPAR?, which in turn complexes with other proteins to form gene transcription factors. Other activities of PGJ2 include suppression of NFkB activation and induction of oxidant stress through a G-protein coupled receptor mechanism. We are exploring the role of PGJ2 in human syndromes of inflammation and have developed unique assays for measuring ?12-PGJ2 and 15d-PGJ2 and their conjugated derivatives using an LC-electrospray-tandem mass spectrometry. As PGJ2 may exert its effects intracellularly via complexes with signalling proteins, a second part of this project is identifying proteins that are modified by PGJ2. To date we have identified several such proteins by LC/MS/MS (Figure 1). In addition, the group is part of the SFI REMEDI and Bloodomics consortium.

     

Collaborators

Internal Collaborators

Dr. Orina Belton
orina.belton@ucd.ie

Dr. Sandra Austin
sandra.austin1@ucd.ie

Ms. Laragh Tormey
laragh.tormey@ucd.ie
Postgraduate student. Research project title: Regulation of gene expression by COX-1 in cardiovascular tissue.

Dr. Glen Doherty
Glen.Doherty@ucd.ie

Dr. James McRedmond
james.mcredmond@ucd.ie

Ms. Sarah McClelland
sarah.mcclelland@ucd.ie
Postgraduate student. Research project title: Cyclooxygenases in atherosclerosis: exploring the cardiovascular risk of COX-2 inhibitors

Dr. Clare Cox
clare.cox@ucd.ie
Postdoctoral fellow. Research project title: Characterisation of a novel anti-atherogenic and anti-thrombotic compound: novel treatment for existing atherosclerosis

Ms. Noelle Griffin
noelle.griffin@ucd.ie

Dr. Ambrose Clarke
ambrose.clarke@ucd.ie

Mr. Oliver Crowley
oliver.crowley@ucd.ie

Mr. Mark Hilliard
mark.hilliard@ucd.ie

Dr. Martina Foy
martina.foy@ucd.ie

Ms. Louise Sewell
louise.sewell@ucd.ie


External Collaborators

Professor Pete Humphries
Trinity College Dublin