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Researchers at UCD

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Alexander Von Kriegsheim

Research Fellow

Systems Biology Ireland
Conway Institute
Belfield
Dublin 4

Tel: +353 1 716
Email: alex.vonkriegsheim@ucd.ie

Biography

I studied chemistry in Germany and decided to move into analytical chemistry during my master project, where I first came into contact with mass spectrometry as a tool to identify proteins. After completing my project I wanted to go abroad and started working in a nascent proteomics group in Oxford. This was initially quite daunting as I went from a student working in a mass spec group to the only person able to operate such a machine in a group dependent on mass spec data.  After two years of a steep learning curve I moved to Glasgow to do my PhD. I chose to move into cell signalling and to use mass spectrometry as a tool to identify novel protein complexes. During my post-doc I then extended this and started using quantitative mass spectrometry and imaging techniques. Data generated in this way can then be used to construct mathematical models of signalling cascades.

Publications

                                                                                                     

Research

Research Interests

 I am currently decoding how external cues regulate the behaviour of cells. Deciphering the underlying program will help in understanding what lies at the root of many diseases. A better understanding of the causes will open new and better avenues of treatment.

My current research area:

  • Modelling cell fate decisions
  • Quantitative phospho-proteomic data and live-cell imaging data is used to generate and validate signalling  networks, which regulate multiple cell fates.