Systems Biology Ireland
I accomplished my M.Sc. studies in Molecular Biology in 2004 at University of Calabria, Cosenza, Italy. Subsequently I obtained two Ph.D. degrees, the first in Animal Pharmacological and Toxicological Sciences, University of Naples ¿Federico II¿, in 2008, with the thesis ¿Identification of pharmacological targets in Bos taurus bladder cancer by mass spectrometry¿; the second in Biomedical and Computer Engineering, Magna Graecia University of Catanzaro, in 2011, with the thesis ¿Characterization of breast cancer microenvironment using quantitative mass spectrometry and pathway analysis¿. During this last Ph.D. I decided to hone my skills in mass spectrometry and chromatographic techniques spending a period as visiting scientist in Yates¿s Lab, Scripps Research Institute, San Diego, California.
My main interest is the application of proteomics to study the cancer pathogenesis. In particular I focus on the analysis of the heterogeneity of signaling involved in cancer development, applying data analysis tools borrowed from bioinformatics and computational biology.
In March 2012 I joined SBI, as Postdoctoral Fellow under the advisorship of Prof. Kolch.
Honours and Awards
| Year: 2008.
Title: Young Scientist Award
| Year 2011 Institution:
Qualification: PhD Subject: Biomedical and Computer Engineering, University Magna Graecia, Catanzaro
| Year 2008 Institution:
Qualification: PhD Subject: Pharmacology and Toxicology in Animal Sciences, University Federico II, Naples
Peer Reviewed Journals
|F. Trapasso, A. Drusco, S. Costinean, H. Alder, R. Aqeilan, R. Iuliano, E. Gaudio, C. Raso, N. Zanesi, C. M. Croce, and A. Fusco (2006) 'Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis'. DNA and cell biology, . [Details]|
|F. Trapasso, F. Pichiorri, M. Gaspari, T. Palumbo, R. I. Aqeilan, E. Gaudio, H. Okumura, R. Iuliano, G. Di Leva, M. Fabbri, D. E. Birk, C. Raso, K. Green-Church, L. G. Spagnoli, S. Venuta, K.Huebner, and C. M. Croce (2008) 'Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells'. Journal of Biological Chemistry, . [Details]|
|Roperto S, Brun B, Paolini F, Urraro C, Russo V, Borzacchiello G, Pagnini U, Raso C., Rizzo C, Roperto F, and Venuti A (2008) 'Detection of Bovine Papillomavirus Type 2 in the Peripheral Blood of Cattle with Urinary Bladder Tumours: Possible Biological Role'. Journal of General Virology, . [Details]|
|Iuliano R., Raso C., Quintiero A., Le Pera I.,Pichiorri F., Palumbo T., Palmieri D., Pattarozzi A., Florio T., Viglietto G., Trapasso F., Croce C.M. and Fusco A (2009) '. The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization'. Journal of Biochemistry, . [Details]|
|S. Roperto, N.A. Colabufo, C. Inglese, C. Urraro, R. Brun, E. Mezza, C., Staibano S., Raso C., P. Maiolino, V. Russo, E. Palma, F. Roperto (2010) 'Sigma-2 receptors expression in bovine papillomavirus-associated urinary bladder tumours'. Journal of Comparative Pathology, . [Details]|
|Roperto S., Borzacchiello G., Brun R., Costanzo F., Faniello M.C., Raso C., Rosati A., Russo V., Saracino D, Turco M.C., Urraro C, Roperto F. (2010) 'Ferritin heavy chain (FHC) is upregulated in papillomavirus-associated urothelial tumor of the urinary bladder in cattle'. Journal of Comparative Pathology, . [Details]|
|Roperto S., De Tullio R., Raso C., Stifanese R., Russo V., Gaspari M.,Borzacchiello G., Averna M., Paciello O., Cuda G., Roperto F (2010) 'Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle'. PLoS ONE, . [Details]|
|Bonadies F., Berardi G., Nicoletti R., Romolo F.S., De Giovanni F., Mirablli R., Santoro A., Raso C., Tagarelli A., Roperto F., Russo V., Roperto S (2011) 'A new, very sensitive method of assessment of ptaquiloside, the major bracken carcinogen in the milk of farm animals'. Food Chemistry, . [Details]|
|Raso C., Cosentino C., Malara N., Gaspari M., Han X., Park SK., McClatchy DB., Renne M., Vadalà N., Cuda G., Mollace V., Yates JR. 3rd., Amato F. (2012) 'Characterization of breast cancer interstitial fluids by TMT labeling, LTQ-Orbitrap Velos mass spectrometry and pathway analysis'. Journal of Proteome Research, . [Details]|
|Paduano F., Ortuso F., Campiglia P., Raso C., Iaccino E., Gaspari M., Gaudio E., Mangone G., Carotenuto A., Bilotta A., Narciso D., Palmieri C., agosti V., Artese A., Gomez-Monterrey I., Sala M., Cuda G., Iuliano R., Perrotti N., Scala G., Viglietto G., Alcaro S., Croce CM., Novellino E., Fusco A., Trapasso F. (2012) 'Isolation and Functional Characterization of Peptide Agonists of PTPRJ, a Tyrosine Phosphatase Receptor Endowed with Tumor Suppressor Activity'. ACS Chemical Biology, . [Details]|
| Currently I am a postdoc level 2 in Systems Biology
Ireland, involved in PRIMES (Protein Interaction Machines in EGFR Signalling)
(FP7-HEALTH-2011-two-stage).PRIMES focuses on the role of protein interactions
to assemble dynamic molecular machines that receive and process information to
coordinate cellular responses. PRIMES investigates the following: (i) How do protein
interactions contribute to the generation of biological specificity in signalling?
(ii) How do pathogenetic perturbations affect protein interaction networks?
(iii) How can we exploit protein interactions as therapeutic targets?