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Daniel Crean

Lecturer/Assistant Professor

School Of Veterinary Medicine
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166238
Email: daniel.crean@ucd.ie

Biography

Dr. Crean graduated with a BSc (Hons) in the biomedical sciences from the Dublin Institute of technology. He subsequently undertook PhD research in the area of ischemia, metabolism and inflammation biology under the supervision of Prof. Cormac Taylor and Dr. Martin Leonard in University College Dublin (UCD). Following the award of PhD, Dr. Crean began a PostDocoral Fellow position in the laboratory of Prof. Evelyn Murphy (UCD) where his research focused on the role of nuclear receptor family 4A [NR4A] receptors as key regulators of inflammatory pathways. Subsequent to this Dr. Crean became a Hoffman-La Roche Fellow in collaboration with Prof. Catherine Godson (UCD) and there investigated, using multidisciplinary approaches, novel mechanisms for the treatment of fibrosis and inflammation in diabetic renal disease. Dr. Crean's key areas of research interest are inflammation and metabolism and currently his group is investigating

1.) The role of NR4A genes in regulating NF-κB signaling in immune cells
2.) The role of NR4A genes in the resolution of inflammation and fibrosis
3.) Novel therapeutics, such as BMP-7 mutants and incretin hormones, for the treatment of fibrosis and inflammation. 

Professional

 

Associations

Association: CURE - 'Current research' internal seminar series [Veterinary medicine, UCD], Function/Role: Organiser
Association: Veterinary medicine Transition year programme, Function/Role: Committee member
Association: Veterinary Medicine research committee, Function/Role: Committee member
Association: American Society of Nephrology, Function/Role: Member
Association: Irish Society of Immunology, Function/Role: Committee member UCD representative
     

Conference Contributions

Daniel Crean (2015) Investigation of the potential reno-protective role of incretin-based therapies in diabetic kidney disease. [Oral Presentation], 2nd Annual Matrix Biology Ireland Meeting, University College Dublin, Ireland , 03-DEC-15 - 04-DEC-15.
Daniel Crean (2014) The role of nuclear receptor family 4A (NR4A) genes in regulating macrophage inflammatory gene expression. [Invited Oral Presentation], Conway Oxygen Related Research Group (CORE), Conway Institute, UCD, Ireland , 06-FEB-14 - 07-FEB-14.
Daniel Crean (2015) [Conference Organising Committee Member], 2015 Annual meeting of the Irish Society for Immunology, Trinity Biomedical Science Institute, Trinity College, Dublin, Ireland , 17-SEP-15 - 18-SEP-15.
Daniel Crean (2015) Computational analysis of BMP-receptor and BMP-antagonist interactions with a view to designing BMP super-agonists and dominant negatives. [Oral Presentation], 28th European Diabetic Nephropathy Study Group (EDNSG), Steno Diabetes Centre, Copenhagen, Denmark , 22-MAY-15 - 23-MAY-15.
Smyth AM, Aherne C, Crean D and Murphy EP (2013) Differential expression of AMPK, PGC1a and NR4A2 in inflammatory arthritis. [Refereed Abstracts], Cell ImmunoMetabolism, Toronto, Canada , 08-JUN-13 - 12-JUN-13.

Committees

Committee : Veterinary Medicine: Transition Year Programme
Committee : Veterinary Medicine: Research and Innovation Committee
Committee : Irish Society of Immunology

Employment

Employer: Hoffman-La Roche
Position: Research Fellow
Employer: Dublin institute of technology, Ireland
Position: Assistant Lecturer in MSc ¿Pharmacology Quality Control Assurance and Biotechnology¿, course code DT233
Employer: University College Dublin, Ireland
Position: Post-doctoral Research Fellow level 1 [PD1], University College Dublin, Ireland

Education

Year 2011 Institution: University college Dublin
Qualification: PhD Subject: School of Medicine and Medical Science
Year 2006 Institution: Dublin institute of technology
Qualification: BSc. (Hons) Subject: Medical and Molecular Cytology
   

Outreach Activities

Contacted Co Wicklow secondary school, St.Kilian¿s (http://www.stkilianscs.com/) to establish Annual Science Day to encourage interest within the Biomedical Sciences (2013- Present)
 

Other Activities

Reviewer - Frontiers in Pharmacology
Reviewer  -Cell Death and Differentiation
Reviewer - PLOS ONE
Reviewer - biomolecules [MDPI]

Publications

     

Peer Reviewed Journals

McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP and Crean D (2017) 'Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells'. Frontiers in Immunology, 8 (7). [DOI] [Details]
McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D. (2017) 'NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells'. Frontiers in Immunology, . [Details]
Eoin P. Cummins, Ciara E. Keogh, Daniel Crean, Cormac T. Taylor (2016) 'The role of HIF in immunity and inflammation'. Molecular Aspects of Medicine, . [Details]
Cummins EP, Keogh CE;Crean D;Taylor CT (2016) 'The role of HIF in immunity and inflammation'. Molecular Aspects of Medicine, 47-48 :24-34. [DOI] [Details]
Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP (2015) 'Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells'. Journal of Immunology, 195 (4):1436-1448. [DOI] [Details]
Crean D, Godson C (2015) 'Specialised lipid mediators and their targets'. Seminars in Immunology, . [DOI] [Details]
Jennings P, Crean D, Aschauer L, Limonciel A, Moenks K, Kern G, Hewitt P, Lhotta K, Lukas A, Wilmes A, Leonard MO. (2015) 'Interleukin-19 as a translational indicator of renal injury'. Archives of Toxicology, . [Details]
Crean D, Godson C (2015) 'Specialised lipid mediators and their targets'. Seminars in immunology, . [Details]
Murphy EP, Crean D (2015) 'Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-kB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis'. Biomolecules, 5 (3):1302-1318. [DOI] [Details]
Sobkowicz AD, Gallagher ME, Reid CJ, Crean D, Carrington SD, Irwin JA. (2014) 'Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2'. Molecular and Cellular Biochemistry, 390 (1-2):101-113. [DOI] [Details]
Sobkowicz AD, Gallagher ME, Reid CJ, Crean D, Carrington SD, Irwin JA. (2014) 'Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2'. Molecular and Cellular Biochemistry, 390 (1-2):101-113. [Details]
Crean D, Bellwon P, Aschauer L, Limonciel A, Moenks K, Hewitt P, Schmidt T, Herrgen K, Dekant W, Lukas A, Bois F, Wilmes A, Jennings P, Leonard MO. (2014) 'Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing'. Toxicology in Vitro, . [Details]
McMorrow, J.P. and Crean, D. and Gogarty, M. and Smyth, A. and Connolly, M. and Cummins, E. and Veale, D. and Fearon, U. and Tak, P.P. and Fitzgerald, O. and Murphy, E.P. (2013) 'Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered nr4a2 activity'. American Journal of Pathology, 183 (4):1243-1257. Available Online [DOI] [Details]
Crean D, Felice L, Pierre P, Jennings P, Leonard MO. (2013) 'Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression'. Experimental Cell Research, . [Details]
Marzaioli V, McMorrow JP, Angerer H, Gilmore A, Crean D, Zocco D, Rooney P, Veale D, Fearon U, Gogarty M, McEvoy AN, Stradner M and Murphy EP. (2012) 'Histamine contributes to increased RANKL/OPG ratio through altered NR4A activity in human chondrocyte cells'. Arthritis and Rheumatism, 64 (10):3290-3301. [Details]
Crean, D,Felice, L,Taylor, CT,Rabb, H,Jennings, P,Leonard, MO (2012) 'Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion'. Molecular and Cellular Biochemistry, 366 :231-238. [DOI] [Details]
Wilmes, A,Crean, D,Aydin, S,Pfaller, W,Jennings, P,Leonard, MO; (2011) 'Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity'. Toxicology in Vitro, 25 :613-622. [DOI] [Details]
                                             

Abstract

Gilmore, A,Marzaioli, V,McMorrow, JP,Angerer, H,Crean, D,Zocco, D,Rooney, P,Veale, D,Fearon, U,Gogarty, M,McEvoy, AN,Stradner, MH,Murphy, EP (2012) HISTAMINE CONTRIBUTES TO AN INCREASED RANKL/OPG RATIO THROUGH ALTERED NR4A ACTIVITY IN HUMAN CHONDROCYTE CELLS. Abstract [Details]
                                                                                           

Research

Research Interests

Dr. Crean's key areas of research interest are inflammation and metabolism and currently his group is investigating 

1.) The role of NR4A genes in regulating NF-κB signaling in immune cells 
2.) The role of NR4A genes in the resolution of inflammation and fibrosis 
3.) Novel therapeutics, such as BMP-7 mutants and incretin hormones, for the treatment of fibrosis and inflammation. 

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : Novel Gremlin-1 Mutants as therapeutics in Diabetic Kidney Disease
Start Date / End Date : 23-MAY-16 / 22-JUL-16
Sponsor : Royal Embassy of Saudi Arabia
Title : Biochemical and molecular insights into novel therapeutics in inflammatory and fibrotic disease
Start Date / End Date : 01-MAR-17 / 28-FEB-18
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : University College Dublin (UCD)
Title : Role of NR4A receptors in regulating NF-¿B mediated inflammatory responses in myeloid cells
Start Date / End Date : 21-FEB-16 / 31-DEC-17
 

Current Postgraduate Students

Hugh Giffney, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Mohamed Ismaiel, Medicine (MD)   -   Thesis Supervisor
Abdulmalik Asaadallah Bokhari, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

 

Enhancement of Teaching

Review and Enhancement of Curriculum

Developing as a Teacher

Innovation & Leadership

Collaborators

Internal Collaborators

Prof Catherine Godson [School of Medicine, UCD]

Dr Eoin Cummins [School of Medicine, UCD]

External Collaborators

Dr Martin Leonard [Centre for Radiation, Chemical and Environmental Hazards, Public Health England]