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Gerald Barry

Lecturer

School Of Veterinary Medicine
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166182
Email: gerald.barry@ucd.ie

Biography

I am a lecturer in the School of Veterinary Medicine in University College Dublin, Ireland. I teach undergraduate students about the wonders of viruses and the diseases that viruses cause. I also manage a research team that is interested in the immune system and  how it defends the body against infection in a species specific manner.
 
We study viruses such as Chikungunya virus, ZIKA virus and Oropouche virus, which are all viruses spread by mosquitos and infect humans; Schmallenberg virus which causes abortions in cattle and sheep and ORF disease, which causes a pox like skin infection in sheep
 
I am always interested in talking to people interested in carrying out research in this area and if you would like to do a PhD or postdoc with my group please drop me an email. On the other hand, if you are just generally interested in viruses and have a question about them or about studying in UCD, please feel free to email or tweet me.

e-mail: gerald.barry@ucd.ie
Twitter: @geraldmbarry

2012 - 2014: Wellcome Trust funded postdoctoral fellow - CVR, University of Glasgow, UK
2009 - 2012: EU 7th Framework Programme funded postdoctoral fellow - University of Edinburgh, UK 
2004 - 2008: PhD, Virology - University of Edinburgh, UK
2003 - 2004: Masters in Biological sciences - University of Edinburgh, UK
1999 - 2003: Undergraduate in Human Genetics - Trinity College, Dublin 

 
 

Professional

               

Education

Year 2008 Institution: University of Edinburgh
Qualification: PhD Subject:
Year 2005 Institution: University of Edinburgh
Qualification: MSc Subject:
Year 2003 Institution: Trinity College Dublin
Qualification: BA Subject:
         

Publications

     

Peer Reviewed Journals

Fragkoudis, R., Breakwell, L., McKimmie, C., Boyd, A., Barry, G., Kohl, A., Merits, A., Fazakerley, J.K. (2007) 'The type I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues, but does not mediate the restricted replication of avirulent virus in central nervous system neurons'. Journal of General Virology, 88 (12):3373-3384. Available Online [DOI] [Details]
Fragkoudis, R., Chi, Y., Siu, R.W.C., Barry, G., Attarzadeh-Yazdi, G., Merits, A., Nash, A.A., Fazakerley, J.K., Kohl, A. (2008) 'Semliki Forest virus strongly reduces mosquito host defence signaling'. Insect Molecular Biology, 17 (6):647-656. Available Online [DOI] [Details]
Barry, G., Breakwell, L., Fragkoudis, R., Attarzadeh-Yazdi, G., Rodriguez-Andres, J., Kohl, A., Fazakerley, J.K. (2009) 'PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response'. Journal of General Virology, 90 (6):1382-1391. Available Online [DOI] [Details]
Attarzadeh-Yazdi, G., Fragkoudis, R., Chi, Y., Siu, R.W.C., ÿlper, L., Barry, G., Rodriguez-Andres, J., Nash, A.A., Bouloy, M., Merits, A., Fazakerley, J.K., Kohl, A. (2009) 'Cell-to-cell spread of the RNA interference response suppresses semliki forest virus (SFV) infection of mosquito cell cultures and cannot be antagonized by SFV'. Journal of Virology, 83 (11):5735-5748. Available Online [DOI] [Details]
Barry, G., Fragkoudis, R., Ferguson, M.C., Lulla, A., Merits, A., Kohl, A., Fazakerley, J.K. (2010) 'Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells'. Journal of Virology, 84 (14):7369-7377. Available Online [DOI] [Details]
Siu, R.W.C., Fragkoudis, R., Simmonds, P., Donald, C.L., Chase-Topping, M.E., Barry, G., Attarzadeh-Yazdi, G., Rodriguez-Andres, J., Nash, A.A., Merits, A., Fazakerley, J.K., Kohl, A. (2011) 'Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: Characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs'. Journal of Virology, 85 (6):2907-2917. Available Online [DOI] [Details]
Rodriguez-Andres, J., Rani, S., Varjak, M., Chase-Topping, M.E., Beck, M.H., Ferguson, M.C., Schnettler, E., Fragkoudis, R., Barry, G., Merits, A., Fazakerley, J.K., Strand, M.R., Kohl, A. (2012) 'Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus'. PLoS Pathogens, 8 (11). Available Online [DOI] [Details]
Barry, G., Alberdi, P., Schnettler, E., Weisheit, S., Kohl, A., Fazakerley, J.K., Bell-Sakyi, L. (2013) 'Gene silencing in tick cell lines using small interfering or long double-stranded RNA'. Experimental and Applied Acarology, 59 (3):319-338. Available Online [DOI] [Details]
Griffiths, S.J., Koegl, M., Boutell, C., Zenner, H.L., Crump, C.M., Pica, F., Gonzalez, O., Friedel, C.C., Barry, G., Martin, K., Craigon, M.H., Chen, R., Kaza, L.N., Fossum, E., Fazakerley, J.K., Efstathiou, S., Volpi, A., Zimmer, R., Ghazal, P., Haas, J. (2013) 'A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication'. PLoS Pathogens, 9 (8). Available Online [DOI] [Details]
Varela, M., Schnettler, E., Caporale, M., Murgia, C., Barry, G., McFarlane, M., McGregor, E., Piras, I.M., Shaw, A., Lamm, C., Janowicz, A., Beer, M., Glass, M., Herder, V., Hahn, K., Baumgärtner, W., Kohl, A., Palmarini, M. (2013) 'Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the Host'. PLoS Pathogens, 9 (1). Available Online [DOI] [Details]
Schnettler, E., Tykalová, H., Watson, M., Sharma, M., Sterken, M.G., Obbard, D.J., Lewis, S.H., McFarlane, M., Bell-Sakyi, L., Barry, G., Weisheit, S., Best, S.M., Kuhn, R.J., Pijlman, G.P., Chase-Topping, M.E., Gould, E.A., Grubhoffer, L., Fazakerley, J.K., Kohl, A. (2014) 'Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses'. Nucleic Acids Research, 42 (14):9436-9446. Available Online [DOI] [Details]
Moniuszko, A., Rückert, C., Alberdi, M.P., Barry, G., Stevenson, B., Fazakerley, J.K., Kohl, A., Bell-Sakyi, L. (2014) 'Coinfection of tick cell lines has variable effects on replication of intracellular bacterial and viral pathogens'. Ticks and Tick-borne Diseases, 5 (4):415-422. Available Online [DOI] [Details]
Barry, G., Varela, M., Ratinier, M., Blomström, A.-L., Caporale, M., Seehusen, F., Hahn, K., Schnettler, E., Baumgärtner, W., Kohl, A., Palmarini, M. (2014) 'NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery'. Journal of General Virology, 95 (PART 8):1640-1646. Available Online [DOI] [Details]
Moniuszko, A., Dunaj, J., Zajkowska, J., Czupryna, P., Ϳwierzbiſska, R., Guziejko, K., Aleksiejczuk, P., Barry, G., Kondrusik, M., Pancewicz, S. (2015) 'Comparison of detection of Borrelia burgdorferi DNA and anti-Borrelia burgdorferi antibodies in patients with erythema migrans in north-eastern Poland'. Advances in Dermatology and Allergology, 32 (1):11-14. Available Online [DOI] [Details]
                                                                                             

Research

Research Interests

My group is interested in developing new therapies for the treatment of virus infections. We study the bodies immune system and how it tries to deal with invading viruses. We are increasingly focused on understanding the 'species barrier'. That is, how viruses cause disease in certain species and not others. By comprehending the molecular basis for the species barrier, we contend that more effective therapies against virus infection can be created. 
     

Teaching

Teaching Philosophy

I predominantly teach Vet undergraduate students about viruses and the infectious diseases caused by viruses.
         

Collaborators

 

External Collaborators

John Fazakerley (Pirbright Institute, UK)
 
Massimo Palmarini (CVR, Glasgow University)
 
Alain Kohl (CVR, Glasgow University)
 
Rennos Fragkoudis (Pirbright Institute, UK)
 
Andres Merits (University of Tartu, Estonia)

Frederick Arnaud (Université de Lyon, France)