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Jane Irwin

Lecturer/Assistant Professor

School Of Veterinary Medicine
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166216
Email: jane.irwin@ucd.ie

Biography

Lecturer in Veterinary Physiology and Biochemistry, University College Dublin, 1999 - 2017

Postdoctoral Researcher, Department of Biochemistry, University College Dublin, 1996 - 1999

Post-Primary Teacher, City of Dublin VEC, 1994 - 1996

Postdoctoral Researcher, Department of Biochemistry, Trinity College Dublin, 1993 - 1995

Ph.D in Biochemistry, Trinity College Dublin, 1994
 





Professional

 

Associations

Association: The Biochemical Society, Function/Role: Member
     

Conference Contributions

Matthews E, Dukes E, Hicks S, Gierow P, Irwin J, Corfield AP, Carrington SD.; (2001) lacrimal glycosidases degrade ocular surface mucins. [Poster Presentation], INVEST OPHTHALMOL VIS SCI (ARVO abstracts)(2001), * , 29-APR-01 - 04-MAY-01.
Matthews E, Dukes E, Hicks S, Gierow P, Irwin J, Corfield AP, Carrington SD.; (2001) Origin of Mucinase Activity in the precorneal tearfilm. National Scientific Medical Meeting 2001. [N/A], Royal Academy of medicine in Ireland, * , 15-DEC-01.
Matthews E, Gierow P, Irwin J, Corfield T, Carrington S; (2003) Is secreted lacrimal a- fucosidase an isoform specialised for mucin degradation?. [N/A], 7th International Workshop on Carcinoma associated Mucins. Crete April 2003, Crete , 14-MAY-03 - 17-APR-03.
Jane A. Irwin, J. Philip Ryan, Paul E.W. Morrissey, Sean Cochrane, Stephen D. Carrington, Alan W. Baird.; (2003) Mucin-degrading glycosidases secreted by rat Peyer's Patches. [Poster Presentation], Conway Insitute, Opening Festival of Research, UCD, Sept 2003, Dublin , 18-SEP-03 - 18-SEP-03.
Matthews E, Dukes E, Hicks S, Gierow P, Irwin J, Corfield T, and Carrington S; (2003) Does the Lacrimal Gland secrete Mucin degrading Glycosidases?. [N/A], 7th International Workshop on Carcinoma associated Mucins. Crete April 2003, Crete , 17-APR-03 - 17-APR-03.
Fahy, J.V., Irwin, J., Innes, A., Woodruff, M. Carrington, S., Donnelly, S.; (2006) Chitinase Activity in Asthmatics and Smokers. [Oral Presentation], ATS San Diego International Conference, San Diego, U.S.A , 19-JUL-06 - 24-JUL-06.
Maischberger, E , Irwin J.A ., Reid C. J., Duggan V, Corfield A P, Carrington S D ; (2007) Mucin Gene Expression in the Equine Endometrium (Poster Presentation). [Poster Presentation], Mucins in Health and Disease (9th International Workshop on Carcinoma -associated Mucins), Cambridge, UK , 07-JUL-07 - 07-JUL-07.
Cummins C, Carrington S D, Irwin J.A , Duggan V., Corfield A P, Reid C. J.; (2007) A histological characterisation of equine cervical mucins at various stages of the reproductive cycle. [Poster Presentation]. [Poster Presentation], Mucins in Health and Disease (9th International Workshop on Carcinoma -associated Mucins), Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Irwin J.A., Reid C.J., Thompson L, Murphy F, Donnelly S, Marlin D, Deaton C, Carrington S.; (2007) Glycoidase activity and mucin expression in equine airway and its association with recurrent airway obstruction. [Poster Presentation], Mucins in Health and Disease (9th International Workshop on Carcinoma -associated Mucins), Robinson College, Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Carrington S D, Cummins C, Irwin J.A , Duggan V Corfield A P, Fitzpatrick E, Reid C. J.; (2007) Expression of mucin and mucinase genes of the equine cervix in the normally cycling mare and in mares with ascending placentitis. [Poster Presentation]. [Poster Presentation], Mucins in Health and Disease (9th International Workshop on Carcinoma -associated Mucins), Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Miranda-CasoLuengo R., Maischberger, E., Cummins, C., Duggan, V.E., Irwin, J.A., Carrington S.D. and Meijer W.G (2009) Actinomycetes in the equine reproductive tract. Poster presentation at 15th International Symposium on the Biology of Actinomycetes in Shanghai, China.; (2011) Actinomycetes in the equine reproductive tract. [Chaired Session], 15th International Symposium on the Biology of Actinomycetes, Shanghai, China , 23-AUG-11 - 25-AUG-09.
Pluta K., Irwin J. A., Gallagher M. E., Evans A. C. O., Carrington S. D. ; (2011) Activity of glycosidases in bovine cervical mucus changes during oestrous cycle. [Chaired Session], 44th Annual Meeting of the Society for the Study of Reproduction,, Oregon Convention Center, Portland, Oregonn , 31-JUL-11 - 04-AUG-11.
Alfattah, MA; McGettigan, PA; Browne JA; Alkhodair KM; Pluta K; Gallagher ME;Reid CJ; Carrington SD; Evans ACO; Irwin JA (2014) Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response. [Oral Presentation], World Congress of Reproductive Biology, Edinburgh, Scotland , 02-SEP-14 - 04-SEP-14.
A. Sobkowicz, M.E. Gallagher, S. Carrington, C. Reid, J.A. Irwin; (2009) Mucinase gene expression and activities from an epithelial respiratory cell model (BEAS-2B) in healthy and asthmatic environment. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 19-JUL-09 - 23-JUL-09.
E. Maischberger, C. Cummins, R Miranda-CasoLuengo, W.G. Meijer, S.D. Carrington, V.E. Duggan, M.E. Gallagher, J.A. Irwin (presenter E. Maischberger); (2009) Characterisation and mucin degradation ability of a bacterial sialidase from Corynebacterium spp. isolated from the equine vagina. [Oral Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 19-JUL-09 - 23-JUL-09.
MAISCHBERGER, E., IRWIN, J.A., CUMMINS, C.A, DUGGAN, V.E., CARRINGTON, S.D., CORFIELD, A.P., REID, C.J. ; (2008) Mucin gene expression in the equine reproductive tract. [Oral Presentation], Association of Veterinary Teaching and Research Workers (Irish Region) 42nd Spring Scientific meeting, Backweston, Kildare , 12-MAR-08 - 12-MAR-08.
E Maischberger, JA Irwin, CA Cummins, E FitzPatrick, VE Duggan, SD Carrington, AP Corfield, CJ Reid ; (2008) Gene expression in the equine reproductive tract ascertained by in-situ hybridisation. [Oral Presentation], European Society for Domestic Animal Reproduction - ESDAR, Utrecht, Netherlands , 20-NOV-08 - 23-NOV-08.
Sobkowicz A, Gallagher ME, Carrington S, Reid C, Fahy JV, Irwin JA; (2008) An investigation of enzymatic activities from epithelial respiratory cells (BEAS2B), sputum and bronchoalveolar lavage samples in healthy and asthmatic environment. [Poster Presentation], 2008 Annual Meeting of the Society for Glycobiology, Forth Worth, Texas, USA , 12-NOV-08 - 15-NOV-08.
Morrissey, P.E.W, Baird, A.W., Folan, M.A., Irwin, J.A.; (2008) Bioactive components of bovine whey inhibit Salmonella typhimurium adhesion to Caco-2 cell monolayers. [Poster Presentation], American Society for Microbiology 108th General Meeting, Boston, MA, USA , 01-JUN-08 - 05-JUN-08.
Ryan MT, Baird AW, Mulholland CW, Irwin JA (JA Irwin presenter); (2008) Practicals: a platform for deep learning? The overall context of practical classes in preclinical veterinary medicine. [Oral Presentation], Association of Veterinary Teaching and Research Workers (Irish Region) 42nd Spring Scientific meeting, Backweston, Co. Kildare , 12-MAR-08 - 12-MAR-08.
Morrissey P, Fijalkowski K, Folan M, Baird AW, Irwin JA; (2007) Effects of bovine whey on Streptococcus mutans adhesion to hydroxylapatite. [Poster Presentation], Irish Society for Immunology, Dublin City University , 13-SEP-07 - 14-SEP-07.
Irwin JA, Reid CJ, Thompson L, Murphy F, Donnelly S, Marlin DJ, Ceaton C, Carrington SD; (2007) Glycosidase activity and mucin expression in equine airway and its association with recurrent airway obstruction. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Sobkowicz A, Gallagher M, Fahy JV, Nally JE, Carrington S, Irwin JA; (2007) Mucin turnover in the human airway. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Maischberger E, Irwin JA, Reid CJ, Duggan V, Corfield AP, Carrington SD; (2007) Mucin gene expression in the equine endometrium. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 07-JUL-07 - 11-JUL-07.
Cummins C, Carrington SD, Irwin JA, Duggan V, Corfield AP, Reid CJ, Fitzpatrick E; (2007) A histological characterisation of equine cervical mucins at various stages of the reproductive cycle. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 07-JUL-07 - 11-JUL-07.
P Morrissey, A Cox, M Folan, AW Baird, JA Irwin; (2006) Bioactive components of milk prevent adhesion of Salmonella typhimurium to Caco-2 cells. [Poster Presentation], British Society of Immunology and Irish Society for Immunology, Stranmillis University College, Belfast, Northern Ireland , 21-SEP-06 - 22-SEP-06.
P Morrissey, C Collins, M Folan, JA Irwin, AW Baird; (2006) Alternative mechanisms of limiting Salmonella infection in a chicken model. [Poster Presentation], British Society of Immunology and Irish Society for Immunology, Stranmillis University College, Belfast, Northern Ireland , 21-SEP-06 - 22-SEP-06.
JA Irwin, M Gallagher, C Murray, K Murnaghan, GG Morgan; (2006) Antimicrobial effects and enzyme inhibition by 1,4-benzoquinone derivatives. [Poster Presentation], Bioscience 2006, Glasgow, U.K , 23-JUL-06 - 27-JUL-06.
Irwin J.A. et al; (2006) Chitinase activity in equine airway and its relationship to recurrent airway obstruction. [Oral Presentation], Association for Veterinary Teaching and Research Work, Scarborough, U.K , 10-APR-06 - 12-APR-06.
JA Irwin, C Murray, M Griffin, S Brusey, K Murnaghan, L Thompson, M Gallagher, GG Morgan; (2005) Novel 1,4-benzoquinones as redox enzyme inhibitors. [Poster Presentation], Bioscience 2005, Glasgow, U.K , 17-JUL-05 - 21-JUL-05.
S Keely, JA Irwin, W-C O'Neill, AW Baird, D Brayden, SD Carrington; (2005) Expression of mucins and mucin-degrading glycosidases in the mucin-secreting intestinal cell line HT29 MTX E12. [Poster Presentation], Mucins in Health and Disease, Robinson College, Cambridge, UK , 09-JUL-05 - 13-JUL-05.
JA Irwin, JP Ryan, S Cochran, S Keely, SD Carrington, AW Baird; (2004) Glycosidase activity in Peyer's patch model co-cultures and a mucin -secreting cell line. [Poster Presentation], Bioscience 2004, Glasgow, U.K , 18-JUL-04 - 21-JUL-04.
JA Irwin, L Thompson, JP Ryan, K Murnaghan, GG Morgan, HJ Windle; (2004) Novel 1,4-benzoquinone thioredoxin reductase inhibitors. [Poster Presentation], Bioscience 2004, Glasgow, U.K , 18-JUL-04 - 22-JUL-04.

Committees

Committee : Widening Participation Committee
Committee : Postgraduate Committee, College of Agriculture, Food Science and Veterinary Medicine
Committee : Veterinary Medicine Programme Board

Employment

Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: Postdoctoral Research Assistant
Employer: The Open University
Position: Associate Lecturer (part-time)
Employer: Trinity College Dublin
Position: Temporary Lecturer, Department of Biochemistry
Employer: Trinity College Dublin
Position: Postdoctoral Research Assistant

Education

Year 1994 Institution: Trinity College Dublin
Qualification: PhD Subject:
Year 1987 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject:

Languages

French:
Gaeilge:
Portuguese:
Spanish:
       

Publications

 

Book Chapters

Motherway M., Tipton K.F., Mc Carthy A.D, Couée I, Irwin J.; (2002) 'Purification of glutamate dehydrogenase from liver and brain' In: Motherway M., Tipton K.F., Mc Carthy A.D, Couée I, Irwin J.; (eds). Current Protocols in Protein Science. Online: Wiley. [DOI] [Details]
Irwin, JA (2012) 'Chapter 8: The role of extremophilic microorganisms and their bioproducts in food processing and production' In: Om V. Singh (eds). Extremophiles: Sustainable Resources and Biotechnological Implications. Wiley-Blackwell: Wiley-Blackwell. [Details]
M.R. Kosseva and J. Irwin; (2009) 'Enzymes in milk and cheese industries' In: P.S. Panesar, S.S. Marwaha, H. Kumar (eds). Enzymes in Food Processing: Fundamentals and Potential Applications. New Delhi, India: I.K. International Publishing House Pvt. Ltd. , pp.51-73 [Details]
J.A. Irwin, K.F. Tipton; (2004) 'Affinity precipitation methods' In: Paul Cutler (eds). Protein Purification Protocols: Methods in Molecular Biology vol 244. Totowa, New Jersey, USA: Humana Press. , pp.205-223 [Details]
 

Peer Reviewed Journals

Sobkowicz AD, Gallagher ME, Reid CJ, Crean D, Carrington SD, Irwin JA. (2014) 'Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2'. Molecular and Cellular Biochemistry, 390 (1-2):101-113. [DOI] [Details]
Pluta K, McGettigan PA, Reid CJ, Browne JA, Irwin JA, Tharmalingam T, Corfield A, Baird AW, Loftus BJ, Evans AC, Carrington SD (2012) 'Molecular aspects of mucin biosynthesis and mucus formation in the bovine cervix during the periestrous period'. Physiological genomics, . [DOI] [Details]
Liu, L; Tharmalingam, T; Maischberger, E; Miranda-CasoLuengo, R; Meijer, WG; Rudd, PM; Irwin, JA (2013) 'A HPLC-based glycoanalytical protocol allows the use of natural O-glycans derived from glycoproteins as substrates for glycosidase discovery from microbial culture'. Glycoconjugate journal, 30 (8):791-800. [DOI] [Details]
Maischberger, E; Cummins, CA; Fitzpatrick, E; Gallagher, ME; Worrall, S;Rousseau, K; Thornton, DJ; Meijer, WG; Miranda-CasoLuengo, R; Duggan, VE;Carrington, SD; Irwin, JA; Reid, CJ (2013) 'The expression of mucin genes and the presence of mucin gene products in the equine endometrium'. Research in Veterinary Science, 95 (1):169-175. [DOI] [Details]
Carrington SD, Irwin JA, Liu L, Rudd PM, Matthews E, Corfield AP (2012) 'Analysing mucin degradation'. Methods in Molecular Biology, 842 :191-215. [DOI] [Details]
Quaglia, D; Irwin, JA; Paradisi, F (2012) 'Horse Liver Alcohol Dehydrogenase: new perspectives for an old enzyme'. Molecular Biotechnology, 52 :244-250. [DOI] Link to full text [Details]
Morrissey PEW; Folan, MA; Fijalkowski, K.; Baird, AW; Irwin, JA (2012) 'Inhibition of Streptococcus mutans binding to hydroxylapatite using partially digested whey protein concentrate and individual whey proteins'. Journal of Functional Foods, 4 (2):559-567. [DOI] [Details]
Pluta, K., Irwin, J.A., Dolphin, C., Richardson, L., Fitzpatrick, E., Gallagher, M.E., Reid, C.J, Crowe, M.A., Roche, J.F., Lonergan, P., Carrington, S.D., Evans, A,C, (2011) 'Glycoproteins and glycosidases of the cervix during the periestrous period in cattle'. Animal Science, 89 (12):4032-4042. [DOI] [Details]
Fijalkowski, K, Czernomysy-Furowicz, D., Irwin, J.A., Nawrotek, P., Pubucewicz, A.; (2012) 'Secretory virulence factors produced by Staphylococcus aureus isolates obtained from mastitic bovine milk-effect on bovine polymorphonuclear neutrophils'. Research in Veterinary Science, 93 (1):82-87. [DOI] [Details]
Irwin JA; (2010) 'Extremophiles and their application to veterinary medicine'. Environmental Technology, 31 (8-9):857-869. [DOI] [Details]
Morrissey, P.E.W., Folan, M.A., Baird A.W., Irwin, J.A.; (2010) 'Effect of a partially digested whey concentrate on Salmonella enterica serotype Typhimurium adhesion to Caco-2 cells'. Food Control, 21 (8):1113-1120. [DOI] [Details]
Reid CJ, Thompson L, Donnelly S, Deaton CM, Marlin DJ, Carrington SD, Irwin JA; (2009) 'The activity and expression of chitinase in the equine lung and its activity in normal horses and animals with recurrent airway obstruction'. Research in Veterinary Science, 87 (1):20-25. [DOI] [Details]
Irwin JA, Ryan MT, Baird AW, Mulholland CW, ; (2009) 'Practical classes: a platform for deep learning? Overall context in the first-year veterinary curriculum'. Journal of Veterinary Medical Education, 2 (NA):180-185. [DOI] [Details]
Maischberger, E., Irwin, J. A., Carrington, S. D., Duggan, V. E., ; (2008) 'Equine post-breeding endometritis: A review'. Irish Veterinary Journal, 61 (3):163-168. [Details]
Flynn RJ, Irwin JA, Olivier M, Sekiya M, Dalton JP, Mulcahy G.; (2007) 'Alternative activation of ruminant macrophages by Fasciola hepatica'. Veterinary Immunology and Immunopathology, 120 (1-2):31-40. [Details]
Sekiya, M; Mulcahy, G; Irwin, JA; Stack, CM; Donnelly, SM; Xu, WB; Collins, P; Dalton, JP; ; (2006) 'Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica'. FEBS Letters, 580 (21):5016-5022. [Details]
Ryan MT, Irwin JA, Bannon FJ, Mulholland CW, Baird AW, ; (2004) 'Observations of veterinary medicine students' approaches to study in pre-clinical years'. Journal of Veterinary Medical Education, 31 (3):242-254. [Details]
Irwin, JA; Baird, AW; ; (2004) 'Extremophiles and their application to veterinary medicine'. Irish Veterinary Journal, 57 (6):348-354. [Details]
Irwin JA, Morrissey PE, Ryan JP, Walshe A, O'Neill SM, Carrington SD, Matthews E, Fitzpatrick E, Mulcahy G, Corfield AP, Dalton JP.; (2004) 'Glycosidase activity in the excretory-secretory products of the liver fluke, Fasciola hepatica'. Parasitology, 129 (4):465-472. [Details]
J.A. Irwin, J.P. Ryan, SD Carrington, A.W. Baird; (2003) 'Mucin-degrading glycosidase activity in rat Peyer's patches'. Irish Journal of Medical Science, 172 (2):22. [Details]
Irwin, JA; Lynch, SV; Coughlan, S; Baker, PJ; Gudmundsson, HM; Alfredsson, GA; Rice, DW; Engel, PC; ; (2003) 'Alanine dehydrogenase from the psychrophilic bacterium strain PA-43: overexpression, molecular characterization, and sequence analysis'. Extremophiles, 7 (2):135-143. [Details]
Ryan, JP; Irwin, JA; ; (2002) 'Practical studies on urine demonstrating principles of clinical and veterinary significance'. Biochemistry and Molecular Biology Education, 30 (2):98-100. [Details]
J.A. Irwin, J.P. Ryan, M. Leonard, S.D. Carrington, A.W. Baird; (2001) 'Mucin-degrading glycosidase activity in Peyer's patches'. Biochemical Society Transactions, 29 :A131. [Details]
Hayden B.M., Cunnane R., Irwin J.A., Gudmundsson H.M., Alfredsson G.A., Engel P.C.; (2001) 'The isolation and characterisation of a cold-adapted metallo-alkaline phosphatase from the Arctic psychrophile strain PA-43'. Biochemical Society Transactions, 29 :A119. [Details]
Irwin, J.A., Ryan, J.P., Leonard, M. Carrington, S.D., Baird, A.W.; (2001) 'Mucin-degrading glycosidase activity in Peyer's patches'. Biochemical Society Transactions, 29 (5):A131. [Details]
E. Matthews, E. Dukes, S. Hicks, P. Gierow , J. Irwin, T. Corfield, S. Carrington; (2001) 'Lacrimal glycosidases degrade ocular surface mucins'. IOVS, 42 :S264. [Details]
Irwin, J. A., Gudmundsson, H. M., Lanzetti, A. J., Alfredsson, G. A., and Engel P. C.; (2001) 'Characterisation of alanine and malate dehydrogenases from a marine psychrophile strain PA-43'. Extremophiles, 5 :199-211. [Details]
J.A. Irwin, H.M. Gudmundsson, G.A. Alfredsson, and P.C. Engel; (2000) 'A novel serine proteinase from the psychrophile Vibrio PA-43'. Biochemical Society Transactions, 28 :A312. [Details]
J.A. Irwin and K.F. Tipton; (1996) 'Affinity precipitation of dehydrogenases with bis-NADH derivatives'. Biochemical Society Transactions, 24 :11S. [Details]
J.A. Irwin and K.F. Tipton; (1995) 'Resolution of lactate dehydrogenase isoforms by affinity precipitation. '. Biochemical Society Transactions, 23 :365S. [Details]
J.A. Irwin and K.F. Tipton; (1995) 'Affinity precipitation: a novel approach to protein purification'. Essays in Biochemistry, 29 :137-156. [Details]
 

Conference Publications

Irwin JA, Murphy EP, Gallagher ME, Ryan MT, Gaines S, McMahon M (2013) Biochemistry teaching in veterinary medicine: the UCD experience Veterinary Education Symposium 2013 [Details]
Sobkowicz A; Gallagher ME; Carrington SD; Reid C; Irwin JA. (2009) Mucinase gene expression and activities from an epithelial respiratory cell model (BEAS-2B), in healthy and asthmatic environment Mucins in Health and Disease, 10th International Workshop on Carcinoma¿Associated Mucins, Robinson College, Cambridge, CB3 9AN, UK [Details]
Maischberger E., Irwin JA; Cummins CA; Duggan VE; Carrington SD; Corfield AP; Reid CJ (2008) Mucin gene expression in the equine reproductive tract 16th International Congress on Animal Reproduction ICAR , Budapest, Hungary [Details]
Sobkowicz A, Gallagher ME, Carrington S, Reid C, Fahy JV, Irwin JA; (2008) An investigation of enzymatic activities from epithelial respiratory cells (BEAS-2B), sputum and bronchoalveolar lavage samples in healthy and asthmatic environments Annual Meeting of the Society for Glycobiology , Fort Worth, Texas, USA [Details]
MAISCHBERGER, E., IRWIN, J.A., CUMMINS, C.A, DUGGAN, V.E., CARRINGTON, S.D., CORFIELD, A.P., REID, C.J. ; (2008) Mucin gene expression in the equine reproductive tract. [Oral Presentation] 42nd meeting of the Association of Veterinary Teaching and Research Workers (Irish Region) at the Backweston Campus Cellbridge [Details]
Carrington, S.D., Cummins, C., Irwin, J.A., Duggan, V., Corfield, A.P., Fitzpatrick, E. and Reid, C.J.; (2007) Expression of mucin and mucinase genes of the equine cervix in the normally cycling mare and in mares with ascending placentitis Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Maischberger, E., Irwin, J., Reid, C.J., Duggan, V., Corfield, A.P. and Carrington, S.D.; (2007) Mucin Gene Expression in the Equine Endometrium Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Irwin, J.A., Reid, C.J., Thompson, L., Murphy, F., Donnelly, S., Marlin, D.J., Deaton, C.M. and Carrington, S.D.; (2007) Glycosidase activity and mucin expression in equine airway and its association with recurrent airway obstruction Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Matthews, E., Royle, L., Gierow, J.P., Corfield, A.P., Berry, M., Rudd P.M., Dwek, R.A., Fitzpatrick, E., Gallagher, M.E., Irwin, J., Reid, C.R. and Carrington, S. D.; (2007) New insights into supramucosal gel turnover: the role of mucin glycosylation Royal Society of Medicine. 8th Jenner Glycobiology and Medicine Symposium. Oct 2007 UCD Dublin Available Online [Details]
Cummins, C., Carrington, S.D., Irwin, J.A., Duggan, V., Corfield, A.P., Reid, C.J. and Fitzpatrick, E.; (2007) A histological characterisation of equine cervical mucins at various stages of the reproductive cycle Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Sobkowicz, A., Gallagher, M., Fahy, J.V., Nally, J. E. , Carrington, S.D. and Irwin, J.; (2007) Mucus turnover in the human airway Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Donnelly S, Irwin J, Innes A, Woodruff PG, Carrington S, Fahy JV.; (2006) Chitinase activity in asthmatics and smokers American Thoracic Society Annual Conference [Details]
J.A. Irwin, J.P. Ryan, M. Leonard, S.D. Carrington, A.W. Baird.; (2001) Mucin-degrading glycosidase activity in Peyer's patches BIOCHEM. SOC. TRANS (2001) 29(5) *, , pp.131 [Details]
Matthews, E.,Dukes, E., Hicks, S., Gierow, P., Irwin, J., Corfield, A., Carrington, S.; (2001) Lacrimal glyocsidases degrade ocular surface mucins Lacrimal glyocsidases degrade ocular surface mucins , pp.S259 [Details]
                       

Abstract

Maischberger, E,Irwin, JA,Cummins, CA,FitzPatrick, E,Duggan, VE,Carrington, SD,Corfield, AP,Reid, CJ (2008) Mucin Gene Expression in the Equine Reproductive Tract Ascertained by In-Situ Hybridisation. Abstract [Details]
                                                                                       

Research

Research Interests

In recent years most of our work has concentrated on the role of glycosidases at mucosal surfaces. These enzymes degrade glycans, are largely but not exclusively lysosomal, and may be membrane-bound or secreted. They can be produced by epithelia and other tissues, and also by the microbial flora resident at epithelial surfaces. In recent years, we examined the role of glycosidases, in particular alpha-fucosidases and sialidase, secreted by human respiratory tract epithelium and respiratory epithelial cell cultures, and their modulation in disease (e.g. asthma), as well as their production by the bacterial flora in the reproductive tract of the mare, particularly sialidases that may play a role in breaking down the protective mucus gel that overlays the epithelial surface. Other work investigated the biological function of chitinase, an enzyme implicated in the innate immune response, and the discovery of novel O-glycanases and glycosylases (with Prof. Pauline Rudd and Dr Li Liu and Dr Rebecca Duke, NIBRT). Along with this we collaborated with Mr Mike Folan of Westgate Biological on the development of novel antimicrobials. These studies investigated the ability of milk protein and lipid formulations to inhibit microbial adhesion to epithelial surfaces.

Our work on the glycosidases of the equine endometrium has been extended more recently to examine the bovine endometrium, this time using a transcriptomic approach.  A study of gene expression in the bovine cervix around perioestrus (Pluta et al., 2012) was extended to cover the endometrium at the same time points and we are analysing these data to obtain a global overview of gene expression at these time points, as well as specifically analysing genes involved in mucin biosynthesis, glycosylation and degradation. This will provide more information about expression of genes that are potentially involved in bovine fertility.

As a continuation of our study of alpha-fucosidases in the respiratory tract epithelium, we are now examining the biological function of alpha-fucosidase 2. The activity of alpha-fucosidase 1 is known to correlate with outcomes in some forms of cancer, in particular breast cancer, and work is ongoing in our laboratory (in collaboration with Prof. Amanda McCann in the School of Medicine) to determine the properties of the less well-studied alpha-fucosidase 2, encoded by the FUCA2 gene. I am also co-supervising a student with Dr Rita Hickey, Teagasc, Moorepark on modulating the mucosal glycome by testing dairy-derived ingredients on a range of cell lines.

 

 

Recent Postgraduates

Mr Paul Morrissey, B.Sc  (Characterisation of antimicrobial whey proteins - funded by Enterprise Ireland and Westgate Biological Ltd, 2004).  Ph.D was awarded in 2009.

Ms Anna Sobkowicz, M.Sc (Mucinase system in the lung - the key to mucus degradation?, funded by HRB, 2005) Ph.D was awarded in 2010.

Ms. Eva Maischberger Diplom. Tzt. (The mucosal barrier function of the equine endometrium, Funded by Dept. of Agriculture Stimulus Fund, 2006). Ph.D was awarded in 2010.


 

Teaching

Teaching Philosophy

I encourage active learning, interaction and curiosity. I try to take advantage of the ways that students learn, so that they will assimilate key concepts and connect these to their clinical relevance. In this environment students can develop critical thinking skills that are essential for their professional development.
         

Collaborators

Internal Collaborators


Dr Colm Reid, Dr Mary Gallagher, Prof. Alan Baird, Prof. David MacHugh, School of Veterinary Medicine UCD

Mr Mike Folan, Westgate Biological Ltd

Prof. Amanda McCann, UCD School of Medicine and Medical Science and Dr Aidan McAlinden, UCD School of Veterinary Medicine

External Collaborators

Dr Rita Hickey, Teagasc, Moorepark, Fermoy