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| David Brayden is Associate Professor of Drug Delivery at the School of Veterinary Medicine and a Fellow of the UCD Conway Institute in UCD. Following a Ph.D. in Pharmacology at the University of Cambridge, UK (1989), and a post-doctoral research fellowship at Stanford University, CA (1991), he set up Elan Corporation's pharmacology laboratory in Dublin (1991). At Elan Biotechnology Research, he became a senior scientist and project manager of several of Elan's Joint-Venture drug delivery research collaborations with US biotech companies. In 2001, he joined UCD as a lecturer in veterinary pharmacology and was appointed Senior Lecturer (2005) and Associate Professor (2006). He completed a successful Principle Investigator Grant from SFI on the topic of oral delivery of novel mucoadhesive polymeric peptide conjugates (2005-2009). Professor Brayden is the Director of an SFI Research Cluster grant (The Irish Drug Delivery Research Network), that was awarded 7.2 million euro by SFI in December, 2007. He is the author or co-author of more than 200 research publications and patents. Professor Brayden serves on the Editorial Advisory Boards of Drug Discovery Today, European Journal of Pharmaceutical Sciences, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics. In 2010 he became an Associate Editor of the new international journal, Therapeutic Delivery. He was Chairman of the UK-Ireland Chapter of the Controlled Release Society (2003-2006), Co-Chair of the Veterinary Programmes at the CRS international conferences (2003-2006) and served on the CRS Board of Scientific Advisors (2006-2009). His research team was awarded the Best Research Paper Prize of the Journal of Veterinary Pharmacology and Therapeutics (2005). In 2012, he was the first Irish scientist to be made a Fellow of the Controlled Release Society. He was also awarded an American Biographical Society Hippocratic Award for services to medicine (2012). At UCD, he was Chairman of the Animal Research Ethics Committee (2005-2007) and is a member of the UCD Research Ethics Committee (2006-) as well as the UCD Promotions and Tenure Committee (elected, 2010). He was Director of Research for the School of Agriculture, Food Science and Veterinary Medicine (2007-2008). On the teaching side, he coordinates undergraduate and postgraduate modules on Biological Fluids and Drug Discovery and Development and contributes to a module on Cell Communication. He contributes Professional Ethics material to the Conway Institute Core Research Skills and Advanced Research Skills modules and also coordinates a 4th level module on Integrated Pharmacology for UCD and Molecular Medicine Ireland. Professor Brayden works as an independent consultant for drug delivery companies and has provided expert pharmacology opinion in three veterinary practice legal cases. His major research interests are in oral peptide delivery and novel formulations of calcitonin and his team typically comprises 4 PhD students, 2 postdocs and a technician. In 2012, he was the first Irish academic to be inducted into the College of Fellows of the Controlled Release Society. |
| Improving macromolecule delivery across intestinal epithelia using in vitro and in vivo bioassays |
| Sponsor : Novo Nordisk A/S Title : Intestinal Transport Enhancement: human tissue model investigations Start Date / End Date : 05-JUL-10 / 04-JAN-12 |
| Sponsor : Merrion Pharmaceuticals Ltd. Title : Funding for Laboratory Consumables Start Date / End Date : 05-JAN-10 / 04-JAN-11 |
| Sponsor : Critical Pharmaceuticals Limited Title : Effect of CriticalSorb-TM on intestinal epithelial drug transport in vitro Start Date / End Date : 01-JAN-10 / 30-JUN-10 |
| Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : Medium chain fatty acid intestinal permeation enhancers for oral delivery of macromolecules Start Date / End Date : 05-JAN-10 / 04-JAN-13 |
| Sponsor : Science Foundation Ireland (SFI) Title : Analysis of intra-articular delivery of salmon calcitonin-hyaluronic polymeric particulates in the KBxN Murine model of arthritis Start Date / End Date : 01-NOV-09 / 31-DEC-10 |
| Sponsor : University College Dublin (UCD) Title : Development of mouse bioassays for identifying novel targets and therapeutics for the treatment of inflammatory diseases Start Date / End Date : 01-APR-10 / 31-DEC-11 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Irish Drug Delivery Network Cluster - TCD Start Date / End Date : 01-DEC-07 / 31-MAY-11 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Irish Drug Delivery Network Cluster - UCC Start Date / End Date : 01-DEC-07 / 31-MAY-11 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Irish Drug Delivery Netwrok Cluster - RCSI Start Date / End Date : 01-DEC-07 / 31-MAY-11 |
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| Sponsor : University College Dublin (UCD) Title : Anti-Inflammatory drug polymer combinations for treating surface wounds Start Date / End Date : 26-MAY-08 / 01-DEC-09 |
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| Sponsor : Science Foundation Ireland (SFI) Title : PEGylated polymer interaction with intestinal P-glycoprotein: drug delivery approach Start Date / End Date : 16-JUN-08 / 11-AUG-08 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Irish Drug Delivery Network Cluster Start Date / End Date : 01-DEC-07 / 31-MAY-11 |
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| Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : In vitro and ex vivo structure function analysis of the gastrointestinal absorption enhancer melittin Start Date / End Date : 12-DEC-07 / 30-NOV-09 |
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| Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET) Title : In vitro models assessing veterinary drug interactions with ABC transporters Start Date / End Date : 15-SEP-07 / 15-AUG-10 |
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| Sponsor : European Commission FP6 Title : Integrated Oral Drug Delivery System Start Date / End Date : 09-OCT-06 / 08-OCT-07 |
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| Sponsor : Pfizer Ltd., UK Title : Interactions of different avermectins with cellular P-glycoprotien efflux systems Start Date / End Date : 01-JAN-03 / 31-DEC-08 |
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| Sponsor : University College Dublin (UCD) Title : Permeability of the intestine in inflammatory bowel disease Start Date / End Date : 01-OCT-02 / 30-SEP-03 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Synthesis, characterisation and oral delivery of novel PEGylated salmon calcitonin conjugates for treatment of osteoporosis Start Date / End Date : 01-JUN-05 / 31-MAY-09 |
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| Sponsor : Health Research Board (HRB) Title : Myosin light chain kinase inhibitors as potential therapeutics for inflammatory bowel disease Start Date / End Date : 01-OCT-02 / 30-JUN-06 |
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| Sponsor : University College Dublin (UCD) Title : Departmental start up funding Start Date / End Date : 06-AUG-01 / 31-JUL-02 |
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| Sponsor : University College Dublin (UCD) Title : Inaugural Irish Drug Delivery Researchers Conference Start Date / End Date : 01-JAN-09 / 30-JUN-10 |
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Brayden, D.J. and Martinez, M.N.; (2007) Advanced Drug delivery Reviews Theme Issue (Prediction of therapeutic and drug delivery outcomes using animal models). New York: Elsevier.  [Details] |
| Brayden, DJ & Baird, A.W.; (2006) Current Opinion in Pharmacology: New Technologies. New York: Elsevier. [Details] |
| Brayden, D. J. & Baird, A. W.; (2004) Advanced Drug Delivery Reviews. Theme Issue. Pathogens and the intestine: mechanisms and exploitation. London: Elsevier. [Details] |
| Brayden, D. J. & Baird, A. W. (2004). Adv. Drug Del. Rev.; (2004) Commentary: apical membrane receptors on intestinal M cells: potential targets for vaccine delivery. [Details] |
| Brayden, D.J.; (1997) Special Issue: Proceedings of the the CRS Ireland Special Symposium on Current Topics in Peptide Delivery. : Elsevier. [Details] |
| Maher, S., Ryan, K. B., Ahmad, T., O¿Driscoll, C. M. & Brayden, D. J. (2012) 'Nanostructures overcoming the intestinal barrier: physiological considerations and mechanistic issues' In: Alonso, MJ & Csaba, N (eds). Nanostructured biomaterials for overcoming biological barriers. London: Royal Society of Chemisty. [Details] |
| Ryan, K. B., Maher, S., Ahmad, T., Brayden, D. J. & C.M. O¿Driscoll (2012) 'Nanostructures overcoming the intestinal barrier: drug delivery strategies' In: Alonso, MJ & Csaba, N (eds). Nanostructured biomaterials for overcoming biological barriers. London: Royal Society of Chemistry. [Details] |
| Brayden, D.J., Oudot, E. & Baird, A.W.; (2010) 'Drug delivery systems in domestic animal species' In: Lees, P., Cunningham, F., Elliot, J (eds). Handbook in Experimental Pharmacology. New York: Springer. [Details] |
| Cutbert, A.W. and Brayden, D.J.; (1988) 'Kinins can stimulate chloride secretion or sodium absorption in different human epithelia' In: Alan Liss Inc (eds). Kinins V. [Details] |
| Brayden, D.J. and Cuthbert, A.W.; (1988) 'Electrogenic sodium absorption in cultured human sweat gland epithelial sheets' In: Wong, P.D.Y. and Young, J.M (eds). Exocrine Secretion. [Details] |
| Bzik, V., Medani, M., Baird, A. W., Winter, D., Brayden, D.J. (2012) 'Mechanisms of Action of Zinc on Intestinal Epithelial Electrogenic Ion Secretion: Insights into its Anti-Diarrheal Actions'. Journal of Pharmacy and Pharmacology, 64 (5):644-653. [Details] |
| Brayden, D.J., Bzik, V., Lewis, A.L. & Illum, L (2012) 'CriticalSorb¿ promotes permeation of flux markers across isolated rat intestinal mucosae and Caco-2 monolayers'. Pharmaceutical Research, . [Details] |
| Mohan, H.M., Maher, S., Collins, D., Walsh, E.G., Winter, D.C., O¿Brien, P.J., Brayden D.J., & Baird, A.W. (2012) 'The mycotoxin, patulin, increases colonic epithelial permeability. Food and Chemical Toxicology'. Food Chemical Toxicology, . [Details] |
| Coco, R., Plapied, L., Pourcelle, V., Jérôme, C., Brayden, D,J,, Schneider, Y.J., & Préat, V. (2012) 'Drug delivery to inflamed colon by nanoparticles: comparison of different strategies'. International Journal of Pharmaceutics, . [Details] |
| Petersen, S. B, Nolan,G., Maher, S., Rahbek,U. L., Guldbrandt,M, Brayden, D. J. (2012) 'Evaluation of alkyl maltosides as intestinal permeation enhancers: Comparison between rat intestinal mucosal sheets and Caco-2 monolayers'. European Journal of Pharmaceutical Sciences, . [Details] |
| Jones, M., Mantovani, G., Blindauer, C., Wang, X., Ryan, S.M., Brayden, D. J. & Haddleton, D.M. (2012) 'Direct peptide conjugation at tyrosine with linear and branched polymeric diazonium salts'. Journal of the American Chemical Society, 134 (17):7406-7413. [Details] | |||||||||
| Walsh, E.G., Maher, S., Devocelle, M., O'Brien, P.J., Baird, A.W., Brayden, DJ.; (2011) 'High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs'. Peptides, 32 (8):1764-1773. [DOI] [Details] |
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| Ryan SM, Frías JM, Wang X, Sayers CT, Haddleton DM, Brayden DJ; (2011) 'PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights'. Journal of Controlled Release, 149 (2):126-132. [Details] |
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| Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ; (2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'. Journal of Medical Microbiology, 60 (Pt 7):968-976. [DOI] [Details] |
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| Rawlinson, LAB,Ryan, SM,Mantovani, G,Syrett, JA,Haddleton, DM,Brayden, DJ; (2010) 'Antibacterial Effects of Poly(2-(dimethylamino ethyl)methacrylate) against Selected Gram-Positive and Gram-Negative Bacteria'. Biomacromolecules, 11 (2):443-453. [DOI] [Details] |
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| Maher, S,Devocelle, M,Ryan, S,McClean, S,Brayden, DJ; (2010) 'Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin'. International Journal of Pharmaceutics, 387 ((1-2)):154-160. [DOI] [Details] |
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| Rawlinson, L. B., O'Brien. P.J. & Brayden, D. J. ; (2010) 'High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures'. Journal of controlled release : official journal of the Controlled Release Society, 146 (6):82-94. [DOI] [Details] | |||||||||
| Cheng, W.P, Thompson, C. P. Ryan, S. M., Aguirre, T., Tetley, L. & Brayden, D.J.; (2010) 'In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes'. Journal of controlled release : official journal of the Controlled Release Society, 147 (2):289-297. [DOI] [Details] |
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| Brayden, D. J. & Maher, S; (2010) 'Oral absorption enhancement: taking the next steps in therapeutic delivery'. Therapeutic Delivery, 1 (1):5-10. [Details] | |||||||||
| Maher, S.,Devocelle, M.,Ryan, S.,McClean, S.,Brayden, D. J.; (2010) 'Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin'. International Journal of Pharmaceutics, 387 (1-21-2):154-60154. [Details] |
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| Wang, X., Maher, S., & Brayden D. J. ; (2010) 'Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate'. Therapeutic Delivery, 1 (1):75-82. [Details] | |||||||||
| Brayden DJ, Oudot EJ, Baird AW; (2010) 'Drug delivery systems in domestic animal species'. Handbook of experimental pharmacology, (199):79-112. [DOI] [Details] | |||||||||
| Brayden DJ, Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, ; (2009) 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers'. Journal of controlled release : official journal of the Controlled Release Society, 135 (1):35-43. [DOI] [Details] | |||||||||
| Brayden DJ, Ryan SM, Wang X, Mantovani G, Sayers CT, Haddleton DM, ; (2009) 'Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate'. Journal of controlled release : official journal of the Controlled Release Society, 135 (1):51-59. [DOI] [Details] | |||||||||
| Jones, M., Mantovani, G., Ryan, S. M., Wang, X., Brayden, D. J., & Haddleton, D. M. ; (2009) 'Phosphine-mediated one-pot thiol-ene ¿click¿ approach to polymer¿protein conjugates'. Chemical Communications, 35 :5272-5274. [DOI] [Details] |
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| Maher, S., Wang, X., Bzik, V, McClean, S. & Brayden, D. J. ; (2009) 'Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies'. European Journal of Pharmaceutical Sciences, 38 (4):301-311. [Details] |
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| Maher, S., Leonard, T.W., Jacobsen, J., Brayden D. J. ; (2009) 'Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic'. ADVANCED DRUG DELIVERY REVIEWS, 61 (15):1427-1429. [Details] |
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| Sayers, C.T., Mantovani, G., Ryan, S. M., Randev, R.K., Keiper, O., Leszczyszyn, O. I., Blindauer, C., Brayden, D. J., & Haddleton, D. M.; (2009) 'Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation. Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation'. Soft Matter, 5 :3038-3046. [DOI] [Details] | |||||||||
| Maher S, Kennelly R, Bzik VA, Baird AW, Wang X, Winter D, Brayden, DJ; (2009) 'Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 38 (4):291-300. [DOI] [Details] | |||||||||
| Callanan JJ, Fletcher NF, Bexiga MG, Brayden DJ, Brankin B, Willett BJ, Hosie MJ, Jacque JM, ; (2009) 'Lymphocyte migration through the blood brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and TNF-alpha within the CNS: studies using an in vitro feline BBB model'. Neuropathology and Applied Neurobiology, . [DOI] [Details] | |||||||||
| Rathbone, MR & Brayden D; (2009) 'Controlled release drug delivery in farmed animals: commercial challenges and academic opportunities'. Current Drug Delivery, 6 (4):383-390. [DOI] [Details] | |||||||||
| Ryan SM, Mantovani G, Wang X, Haddleton DM, Brayden DJ.; (2008) 'Advances in PEGylation of important biotech molecules: delivery aspects'. Expert Opinion in Drug Delivery, 5 (4):371-383. [Details] |
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| Fletcher, N. F., Bexiga, M., Brayden, D. J., Brankin, B., Willett, B. J., Hosie, M. J., Jacque, J. M., Callanan, J. J., ; (2008) 'Cell migration through the blood brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tnf-alpha within the CNS: studies using an in vitro feline BBB model'. Journal of Neuroimmunology, 197 (2):161-161. [Details] | |||||||||
| Brayden DJ, Feighery LM, Smith P, O'Mahony L, Fallon PG, ; (2008) 'Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease'. Digestive Diseases and Sciences, 53 (9):2495-2506. [DOI] [Details] | |||||||||
| Brayden DJ, Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue D, Mrsny RJ, ; (2008) 'Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro'. Pharmaceutical Research, 25 (6):1377-1386. [DOI] [Details] | |||||||||
| Brayden DJ, Cox AB, Rawlinson LA, Baird AW, Bzik V, ; (2008) 'In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. typhimurium in rat intestinal ileal mucosae'. Pharmaceutical Research, 25 (1):114-122. [DOI] [Details] | |||||||||
| Brayden DJ, Feighery L, Smyth A, Keely S, Baird AW, O'Connor WT, Callanan JJ, ; (2008) 'Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury'. The Journal of trauma, 64 (1):131-11. [DOI] [Details] | |||||||||
| Callanan JJ, Fletcher NF, Brayden DJ, Brankin B, ; (2008) 'Feline immunodeficiency virus infection: a valuable model to study HIV-1 associated encephalitis'. Veterinary Immunology and Immunopathology, 123 (1-2):134-137. [DOI] [Details] | |||||||||
| Maher S, Brayden DJ, Feighery L, McClean S; (2008) 'Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs'. Critical Reviews in Therapeutic Drug Carrier Systems, 25 (2):117-168. [Details] |
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| Brayden DJ, Keely S, Rawlinson LA, Haddleton DM, ; (2008) 'A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge'. Pharmaceutical Research, 25 (5):1193-1201. [DOI] [Details] | |||||||||
| Griffin J, Brayden DJ, ; (2008) 'Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers'. Veterinary Research, 32 (1):93-106. [DOI] [Details] | |||||||||
| Maher, S; Feighery, L; Brayden, DJ; McClean, S; ; (2007) 'Melittin as an epithelial permeability enhancer I: Investigation of its mechanism of action in Caco-2 monolayers'. PHARMACEUTICAL RESEARCH, 24 (7):1336-1345. [Details] |
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| Maher, S, Feighery, L, Brayden, DJ, McClean, S, ; (2007) 'Melittin as a permeability enhancer II: In vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae'. Pharmaceutical Research, 24 :1346-1356. [Details] | |||||||||
| Brayden, D. J., Martinez, M. N., ; (2007) 'Prediction of therapeutic and drug delivery outcomes using animal models - Preface'. ADVANCED DRUG DELIVERY REVIEWS, 59 (11):1071-1072. [Details] | |||||||||
| Brayden, D.J. and Baird, A.W.; (2006) 'Pharmacology applied: delivering the goods'. Current Opinion in Pharmacology, 6 (5):491-493. [Details] | |||||||||
| Brayden, D.J. ; (2006) 'Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET'. Expert Opinion in Drug Delivery, 3 (5):685-692. [Details] | |||||||||
| Brayden DJ, Soni J, Baird AW, O'Brien LM, McElroy M, Callanan JJ, Bassett HF, Campion D, ; (2006) 'Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function'. Journal of controlled release : official journal of the Controlled Release Society, 115 (1):68-77. [DOI] [Details] | |||||||||
| Fletcher, NF; Brayden, DJ; Brankin, B; Worrall, S; Callanan, JJ; ; (2006) 'Growth and characterisation of a cell culture model of the feline blood-brain barrier'. Veterinary Immunology and Immunopathology, 109 (3-4):233-244. [Details] | |||||||||
| Leonard, T. W., O'Toole, E., Brennan, F., Brayden, D.J.; (2006) 'Absorption enhancement: promoting the oral absorption of drugs in humans using Gastro-Intestinal Permeation Enhancement Technology (GIPET)'. Drug Delivery Technology, :2-8. [Details] | |||||||||
| Limer, AJ; Rullay, AK; San Miguel, V; Peinado, C; Keely, S; Fitzpatrick, E; Carrington, SD; Brayden, D; Haddleton, DM; ; (2006) 'Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion'. Reactive and Functional Polymers, 66 (1):51-64. [Details] | |||||||||
| Brayden, D. J., Jepson, MA. R. & Baird, A. W. ; (2005) 'Intestinal Peyer's patches and oral vaccine targeting. Invited Keynote Review'. DRUG DISCOVERY TODAY, 10 (17):1145-1157. [Details] | |||||||||
| Roth-Walter, F; Bohle, B; Scholl, I; Untersmayr, E; Scheiner, O; Boltz-Nitulescu, G; Gabor, F; Brayden, DJ; Jensen-Jarolim, E; ; (2005) 'Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles'. IMMUNOLOGY LETTERS, 100 (2):182-188. [Details] | |||||||||
| Keely, S; Rullay, A; Wilson, C; Carmichael, A; Carrington, S; Corfield, A; Haddleton, DM; Brayden, DJ; ; (2005) 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers'. PHARMACEUTICAL RESEARCH, 22 (1):38-49. [Details] |
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| Griffin, J; Fletcher, N; Clemence, R; Blanchflower, S; Brayden, DJ; ; (2005) 'Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein'. Journal of Veterinary Pharmacology and Therapeutics, 28 (3):257-265. [Details] | |||||||||
| Brayden, D. J. & Baird, A. W.; (2004) 'Preface. Pathogen invasion across the intestine: mechanisms and potential exploitation'. Advanced Drugs Delivery Review, 56 (6):717-719. [Details] | |||||||||
| Lo, D; Tynan, W; Dickerson, J; Scharf, M; Cooper, J; Byrne, D; Brayden, D; Higgins, L; Evans, C; O'Mahony, DJ; ; (2004) 'Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures'. International Immunology, 16 (1):91-99. [Details] | |||||||||
| Baird AW, Brayden DJ, ; (2004) 'Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery'. ADVANCED DRUG DELIVERY REVIEWS, 56 (6):721-726. [DOI] [Details] | |||||||||
| Brayden DJ, Baird AW, Campion DP, O'Brien L, ; (2004) 'Oral delivery of pathogens from the intestine to the nervous system'. Journal of Drug Targeting, 12 (2):71-78. [DOI] [Details] | |||||||||
| Brayden, D. J. ; (2003) 'Novel drug delivery systems in veterinary medicine'. IRISH VETERINARY JOURNAL, 56 (6):310-316. [Details] | |||||||||
| Brayden DJ, ; (2003) 'Controlled release technologies for drug delivery'. Drug Discovery Today, 8 (21):976-978. [Details] | |||||||||
| Lo, D., Tynan, W., Dickerson, J., Mendy, J. Chang, H-W., Scharf, Byrne, D., Brayden, D.J., Higgins, L., Evans, C., O,Mahoby, D.; (2003) 'Peptidoglycan recognition protein expression in mouse Peyer's patch follicle-associated epithelium suggests functional specialization'. Cellular Immunology, Cellular Immunology (In Press) (224 (1)):8-16. [Details] | |||||||||
| Lo, D., Hilbush, B., Mah, S., Brayden, D., Byrne, D., Higgins, L., O'Mahony, D; (2002) 'Catching target receptors for drug and vaccine delivery using TOGA expression profiling'. Advanced Drugs Delivery Review, 54 :1213-1223. [Details] | |||||||||
| Conway, M., Madrigal-Estebas, L., McClean, S., Brayden, D.J. and Mills, K.H.G.; (2001) 'Protection against B. pertussis infection following parenteral or oral immunisationwith antigens entrapped in biodegradable particles: effect of formulation and route of administration on Th1 and Th2 cells'. Vaccine, (19):1940-1950. [Details] | |||||||||
| Brayden, D.; (2001) 'Oral vaccination in man using microparticles: current status'. European Journal of Pharmacology, 14 :183-189. [Details] | |||||||||
| Clark, A., Blair, H., Liang, L., Brey, R., Brayden, D. and Hirst, B. H.; (2001) 'Targeting polymerised liposome vaccine carriers to intestinal M cells'. Vaccine, 20 (1-2):208-217. [Details] | |||||||||
| Brayden, D. and Baird, A.W.; (2001) 'Microparticle vaccine approachesto stimulate mucosal immunisation'. Microbes and Infection, 3 :867-876. [Details] | |||||||||
| Baird AW, Brayden DJ, ; (2001) 'Microparticle vaccine approaches to stimulate mucosal immunisation'. Microbes and Infection, 3 (10):867-876. [Details] | |||||||||
| Brayden DJ, ; (2001) 'Oral vaccination in man using antigens in particles: current status'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 14 (3):183-189. [Details] | |||||||||
| Brayden, D.J., Templeton, L., McClean, S. et al; (2001) 'Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta amyloid in mice'. Vaccine, 19 :4185-4193. [Details] | |||||||||
| Leonard, M., Creed, E., Brayden, D. and Baird, A.W.; (2000) 'Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro'. Pharmaceutical Research, 17 (4):476-478. [Details] | |||||||||
| Leonard, M, Creed, E, Brayden, D, Baird, AW, ; (2000) 'Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport'. Pharmaceutical Research, 17 (10):1181-1188. [Details] | |||||||||
| Gullberg, E; Leonard, M; Karlsson, J; Hopkins, AM; Brayden, D; Baird, AW; Artursson, P; ; (2000) 'Expression of specific markers and particle transport in a new human intestinal M-cell model'. Biochemical and Biophysical Research Communications, 279 (3):808-813. [Details] | |||||||||
| Brayden, D.J. and O'Mahony, D.; (1998) 'Novel drug delivery gateways for biotechnology products: polypeptides and vaccines'. Pharmaceutical Science & Technology Today, 1 (7):289-297. [Details] | |||||||||
| McClean, S., Prosser, E., Meehan, E., O'Malley, D., Blark, N., Ramtoola, Z. and Brayden, D.J.; (1998) 'Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia'. European Journal of Pharmaceutical Science, 6 :153-163. [Details] | |||||||||
| Brayden, D.J., Moriarty, D. and Baird, A.W.; (1998) 'A novel in vitro electrophysiological bioassay for transport of loperamide across intestinal epithelia'. Pharmaceutical Research, 14 (7):942-945. [Details] | |||||||||
| Brayden, D.J.; (1997) 'Human intestinal epithelial monolayers as pre-screens for oral drug delivery'. Pharmaceutical News, 4 :111-115. [Details] | |||||||||
| Baird. A.W., Taylor, C.T. and Brayden, D.J.; (1997) 'A review of the pharmacology and in vitro drug delivery of the anti-diarrhoeal agents: berberine and loperamide'. Advanced Drugs Delivery Review, 23 :111-120. [Details] | |||||||||
| Raoof, A., Moriarty, D., Brayden, D.J. et al; (1997) 'Comparison of methodologies for evaluating regional inestinal permeability'. Advances in Experimental Medical Biology, 423 :181-189. [Details] | |||||||||
| Brayden, D.J., Creed, E., Meehan, E. and O'Malley, K; (1995) 'Passive transepithelial diltiazem absorption across intestinal tissue leading to tight junction openings'. Journal of Controlled Release, 38 :193-203. [Details] | |||||||||
| Brayden, D.J. and Fitzpatrick, J.M.; (1995) 'Cutured human sweat gland epithelia: isolation of glands using neutral red. '. Pharmaceutical Research, 12 :171-175. [Details] | |||||||||
| Brayden, D.J. and Baird, A.W.; (1994) 'A distinctive eletrophysiological signature from the Peyer's patch of the rabbit'. British Journal of Clinical Pharmacology, 113 :593-599. [Details] | |||||||||
| Brayden, D.J., Krouse, M.E., Law, T. and Wine, J.J. ; (1993) 'Stilbenes stimulate T84 chloride secretion by elevating calcium'. American Journal of Physiology, 264 :G325-G333. [Details] | |||||||||
| Brayden, D.J., Pickles, R. J.and Cuthbert, A.W.; (1991) 'Ion transport in cultured epithelia from human sweat glands: comparison of normal and CF tissues'. British Journal of Clinical Pharmacology, 102 :57-65. [Details] | |||||||||
| Wine, J.J., Brayden, D.J., Hagiwara, G. et al.; (1991) 'Cystic fibrosis, CFTR, and the rectifying chloride channel'. Advances in Experimental Medical Biology, 290 :253-273. [Details] | |||||||||
| Brayden, D.J. and Cuthbert, A.W.; (1990) 'A novel method for culturing sweat gland epithelia;comparison of normal and cystic fibrosis tissues. '. British Journal of Clinical Pharmacology, 29 :235-238. [Details] | |||||||||
| CUTHBERT, AW; BRAYDEN, DJ; DUNNE, A; SMYTH, RL; WALLWORK, J; ; (1990) 'ALTERED SENSITIVITY TO AMILORIDE IN CYSTIC-FIBROSIS - OBSERVATIONS USING CULTURED SWEAT GLANDS'. British Journal of Clinical Pharmacology, 29 (2):227-234. [Details] | |||||||||
| Brayden, D.J., Hanley, M.R., Thastrup, O., and Cuthbert, A.W.; (1989) 'Thapsigargin, a new calcium-dependent epithelial anion secretagogue'. British Journal of Clinical Pharmacology, 98 :809-816. [Details] | |||||||||
| Brayden, A.W., Cuthbert, A.W., and Lee, C.M.; (1988) 'Human eccrine sweat gland epithelial cultures express ductal characteristics'. Journal of Physiology, 405 :657-676. [Details] | |||||||||
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| Walsh, E. G., Leonard, T. W. & Brayden, D. J.; (2011) High-content analysis (HCA) for determination of potential cytotoxicity effects of sodium caprate (C10) on Caco-2 cells Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 821 [Details] |
| Ahmad, T., Simpson, J. C. & Brayden, D.J. ; (2011) Uptake of glucan particles via dectin-1 receptor mediated endocytosis in Peyer¿s patches? Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 524 [Details] |
| Petersen, S. B, Nolan, G., Maher, S., Rahbek, U. L., Guldbrandt, M., & Brayden, D. J. ; (2011) Tetradecylmaltoside is a permeability enhancer: isolated rat colonic mucosae in Ussing chambers Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 759 [Details] |
| Ryan, S.M, Patel, H.B., Kornerup, K. N., Tajber, L., Umerska, A., Perretti, M., & Brayden, D. J. ; (2011) Intra-articular delivery of salmon calcitonin nanocomplexes to the K/BxN murine model of osteoarthritis 24th conference of the European Society of Biomaterials [Details] |
| Maher, S., Walsh, E. G., Bahar, B, Baird, A. W. & Brayden, D. J. ; (2011) Investigations of intestinal epithelial compensatory responses to permeation enhancement caused by sodium caprate (C10) . In: Selected Podium Session, Abstract 179 eds. Transactions of the 38th Int. Soc. Controlled Release Society, Maryland [Details] |
| Aguirre, T., Rosa, M. Coulter, I., & Brayden, D. J. ; (2011) Enhancement of Intestinal Absorption of Salmon Calcitonin Using a Novel Liquid Emulsion Drug Delivery System LEDDS® Transactions of the 38th Int. Soc. Controlled Release Society, Maryland, Abstract 687 [Details] | |||||||||
| Ahmad, T., Ostroff, G. R., Wang, M., Czech, M. P., & Brayden, D. J. ; (2010) Uptake and translocation of yeast-derived glucan microparticles across an vitro M-cell model Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details] | |||||||||
| Bzik, V., Sheridan, C., & Brayden, D. J. ; (2010) Inhibition of electrogenic ion transport in rat colonic mucosae by zinc is enabled by the tight junction opener, cytochalasin D Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details] | |||||||||
| Ryan, S. M., McMorrow, J. P., Murphy, E. P. & Brayden, D. J.; (2010) Salmon calcitonin reduces expression of a novel biomarker family in inflammatory arthritis:a new target for controlled release formulations? Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon [Details] | |||||||||
| Rawlinson, L.B & Brayden, D. J. ; (2010) Use of cellular high content analysis (HCA) to screen cytotoxicity of antimicrobial polymers: A comparison with MTT and whole tissue assays 11th Annual Scientific Meeting of the Australian Society for Antimicrobials (Antimicrobials 2010) [Details] | |||||||||
| D. J. Brayden; (2010) Intestinal Permeation Enhancement for Poorly Absorbed Drugs: Matching Mechanism of Action with Biological Assessment Transactions of the 37th Int. Soc. Controlled Release Society, Portland [Details] | |||||||||
| Ryan, SM, McMorrow, J., Murphy, E.P. & Brayden, D. J. ; (2009) Salmon calcitonin as a potential therapeutic for osteoarthritis and rheumatoid arthritis 36th Int. Soc. Controlled Release Society, Copenhagen [Details] | |||||||||
| Bzik, V & Brayden DJ; (2009) Permeating-enhancing and cytotoxic effects of 1-phenyl piperazine in rat colonic mucosa 36th Int. Soc. Controlled Release Society [Details] | |||||||||
| Wang, X & Brayden, D.J. ; (2009) Bone regeneration after acute injected bisphophonate and calcitonin repeated treatments in overiectomised rats Osteoporosis Conference 2009, Manchester [Details] | |||||||||
| Bzik, V & Brayden DJ; (2008) Comparison of three in vitro intestinal diffusion systems Transactions of the 35th Int. Soc. Controlled Release Society, New York [Details] | |||||||||
| Fletcher, N.F., Bexiga, M., Brayden, D. J., Brankin, B., Willett, B. J., Hosie, M. J., Jacque, J. M. & Callanan, J. J.; (2008) Cell migration through the blood-brain barrier in FIV virus infection is significantly influenced by the pre-existence of virus and TNF-a within the CNS: studies using an in vitro feline BBB model J. Immunology, 197: p. 161, Abstract 3 [Details] | |||||||||
| Ryan, S., Wang, X., Mantovani, G, Haddleton, D. M. & Brayden, D.J.; (2008) Enhanced intestinal delivery and stability both in vivo and in vitro of site-specific PEGylation of salmon calcitonin to different molecular sizes of POLYPEG® Transactions of the 35th Int. Soc. Controlled Release Society, Abstract 918 [Details] | |||||||||
| Maher, S., Wang, X, Bzik, V, McClean, S. & Brayden, D. J.; (2008) Increased intestinal permeability induced by the anti-microbial peptide, melittin: in vivo and ex vivo studies Transactions of the 35th Int. Soc. Controlled Release Society, Abstract 912 [Details] | |||||||||
| Wang, X, Tambuwala, M., & Brayden, D. J.; (2008) Investigation of the absorption-enhancing effects of ethanol in rats Transactions of the 35th Int. Soc. Controlled Release Society [Details] | |||||||||
| Wang, X., Tambuwala, M., & Brayden, DJ; (2008) Improved absorption of salmon calcitonin from rat intestine in vivo with sodium caprate and a mucolytic, n-acetyl cysteine Transactions of the 35th Int. Soc. Controlled Release Society [Details] | |||||||||
| Rawlinson, LB & Brayden DJ; (2008) A methacrylate polymer is bactericidal to Gram-positive and Gram-negative bacteria Society for General Microbiology [Details] | |||||||||
| Haddleton, D. M., Mantovani, G. & Brayden, D. J. ; (2007) Synthetic glycopolymers and protein bioconjugates from living radical polymerization 235th American Chemical Society meeting [Details] | |||||||||
| Fletcher, N.F., Brayden, D., Brankin, B., Willett, B., Hosie, M. and Callanan, J.J.; (2007) Migration of feline immunodeficiency virus infected lymphocytes across an invitro feline blood brain barrier model is promoted by the basolateral presence of FIV and TNF 25th Annual metting of European Society of Veterinary Pathology [Details] | |||||||||
| Keely, S., Carrington, S., Haddleton, D.M. Brayden, D. J.; (2006) An in vitro mucus-secreting intestinal cell model for screening antibiotic effects of polymers Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 20-JUL-06 - 24-JUL-06 [Details] | |||||||||
| Fletcher, N., Brayden, D., Brankin, B. and Callanan, J.J.; (2006) The interaction of feline immunodeficiency virus with a cell culture model of the felin blood brain barrier Neuroscience Ireland, Inagural Conference , 21-SEP-06 - 22-SEP-06 [Details] | |||||||||
| Keely, S., Limer, A., Wilson, C., Carrington, S., Haddleton, D.M., Brayden, D.J.; (2006) In vitro mucus-secreting intestinal models for adhesion of conjugated and branched pDMAEMA polymers Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 22-JUL-06 - 26-JUL-06 [Details] | |||||||||
| Ryan, S.M., Tao, L., Haddleton, D.M. Brayden, D. J.; (2006) Oral polymeric conjugate system for salmon calcitonin: cytotoxicity studies Proceedings of the International Symposium of Controlled Release of Bioactive Materials , 20-JUL-06 - 24-JUL-06 [Details] | |||||||||
| Haddleton, DM; Limer, AJ; Mantovani, G; Brayden, D; Miguel, VS; ; (2005) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Amphiphilic polymers from living radical polymerization for personal care applications , pp.4170-4171 [Details] | |||||||||
| Halligan, E, Reid, C, Keely, S, Brayden, DJ, Carrington, S, Lunec, J, ; (2005) FREE RADICAL RESEARCH The role of the mucus barrier and lipid peroxides in diet: An in vitro model of a dietary genotoxicity and colorectal cancer , pp.61-61 [Details] | |||||||||
| Fletcher, N.F., Brayden, D.J., Brankin, B. Worrall S. & Callanan J.J.; (2005) Growth and characterisation of a felin in-vitro blood-brain barrier 23rd metting of the European Society of Veterinary Pathology , 07-SEP-05 - 10-SEP-05 [Details] | |||||||||
| Haddleton, D.M., Limer, A.J., Mantovani, G, Brayden, D. San Miguel, V.; (2005) Amphiphilic polymers from living radical polymerization for personal care applications 230th American Chemical Society Meeting , 28-AUG-05 - 31-AUG-05 [Details] | |||||||||
| Haddleton, DM; Rullay, AK; Limer, AJ; Carrington, S; Keely, S; Brayden, D; ; (2004) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Mucoadhesive polymers from living radical polymerisation , pp.358-358 [Details] | |||||||||
| Feighery, LM; Quinn, TM; Baird, AW; Brayden, DJ; ; (2004) MOLECULAR BIOLOGY OF THE CELL Pharmacological manipulation of tight junctions in rat colonic mucosa in vitro , pp.67-67 [Details] | |||||||||
| Feighery, LM; Keely, S; Smyth, A; Gilchrist, M; Baird, AW; O'Connor, WT; Brayden, DJ; ; (2004) MOLECULAR BIOLOGY OF THE CELL Demonstration of compromised ileal structure and function following severe acute trauma to the left forebrain in the isoflourane anaesthetized rat , pp.67-67 [Details] | |||||||||
| Forrest, AS; Quinn, T; Keenan, AK; Usher, C; Parsons, ME; Brayden, DJ; Baird, AW; ; (2002) BRITISH JOURNAL OF PHARMACOLOGY Megacolon in the streptozotocin-treated diabetic rat [Details] | |||||||||
| Ulrich, C., Quinn, T., Baird, A.W., Jones, B, Brayden, D.J.; (2002) Ion transport across isolated canine colonic mucosae: leaky tight junctions in inflammatory bowel disease Irish Association of Veterinary Teachers and Research Workers UCD, , 04-NOV-02 [Details] | |||||||||
| Cochrane, S; Quinn, T; O'Donoghue, DP; Baird, AW; Brayden, DJ; ; (2002) BRITISH JOURNAL OF PHARMACOLOGY The effect of myosin light chain kinase inhibition on pharmalogically induced changes in paracellular intestinal epithelial permeability [Details] | |||||||||
| Byrne, D; Leonard, M; Mah, S; Lo, D; Baird, A; O'Mahony, D; Brayden, D; ; (2001) BRITISH JOURNAL OF PHARMACOLOGY Differential expression of genes in a Peyer's Patch M cell co-culture model by TOGA (TM) [Details] | |||||||||
| Le Ferrec, E., Chesne, C., Artursson, P., Brayden, D. et al. (2001) 29, 6; (2001) In vitro models of the intestinal barrier The report and recommendations of the ECVAM workshop *, , pp.649-668 [Details] | |||||||||
| Leonard, M; Brayden, DJ; Baird, AW; ; (2001) BRITISH JOURNAL OF PHARMACOLOGY An in vitro intestinal cell culture model of M-cells displays a Th1 type cytokine profile [Details] | |||||||||
| Leonard, M; Creed, E; Brayden, D; Baird, AW; ; (2000) PHARMACEUTICAL RESEARCH Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro , pp.476-478 [Details] | |||||||||
| Brayden, D.J., Bourke, E. and Baird, A.W.; (1996) Berberine: enhancement of flux of a poorly absorbed anti-diarrhoeal agent as indicated by a parallel electrogenic ion transport in rat colon and T84 . In: Couvreur, P., Duchenne, D, and Kalles, I eds. Minutes of the European Symposium on Formulation of Poorly Soluble Drugs. In: Editions de Sante , pp.191-194 [Details] | |||||||||
| Brayden, D.J. and Kelly, J.G. (21); (1994) Rabbit Peyer's patches: a novel electrophysiological signature in response to cholinomimetics Proceedings of the Interntional Symposium Control. Rel. Bioactive Mater *, , 01-JUL-94 , pp.276-277 [Details] | |||||||||
| Brayden, D.J. and Kelly, J.G.; (1994) A novel electrophysiological signature from the Peyer's patch of rabbit intestine. Editions de Sante. (1994) Minutes of the European Symposium in in vitro and ex vivo test systems to rationalize drug design and delivery *, , pp.217-221 [Details] | |||||||||
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| Brayden, D. J., Armstrong, G., O¿Driscoll, C. M. ; (2010) The 2nd Annual Irish Drug Delivery Network Conference with UK and Ireland Controlled Release Society-Advancing Drug Delivery. Informa, London. [Details] |
| Gullberg, E. et al; (2001) Human M cells delivered in a box. Reports [Details] |
| Brayden, D.J.; (2004) SCRIP Magazine. Invited Review Articles [Details] |
| Brayden, D.J.; (2003) Drug Discovery Today. Invited Review Articles [Details] |
| Year: 2009. Title: Distinguished Service Award of the Controlled Release Society |
| Year: 2011. Title: Inclusion in Who's Who in the World |
| Year: 2006. Title: Distinguished Service Plaque of the Controlled Release Society |
| Year: 2006. Title: Journal of Veterinary Pharmacology and Therapeutics Best Research Paper |
| Year: 2005. Title: CRS Distinguished Service Award |
| Year: 2004. Title: CRS and PR Pharmaceuticals Award |
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| Year: 2003. Title: Distinguished Service Plaque |
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| Year: 2002. Title: President's Research Award |
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| Year: 1998. Title: IBC Poster Award |
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| Year: 1994. Title: Sir Patrick Dun Gold Medal |
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| Year: 1984. Title: Zeneca Pharmaceuticals Prize |
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| Association: British Pharmacologicl Society, Function/Role: Ordinary Member |
| Association: American Association of Pharmaceutical Sciences, Function/Role: Member-at-Large Committee for Short Courses in Education |
| Association: Controlled Release Society, Function/Role: Vice Chair, Veterinary Products Sub-Committee and Elected Member of Board of Scientific Advisors |
| Association: UK-Ireland CRS, Function/Role: Co-Founder and Chairman (2003-2006) |
| Association: Royal Academy for Medicine in Ireland, Function/Role: Elected Fellow in 1997 |
| Association: New York Acadamy of Sciences, Function/Role: Elected member | |||||||||
| Association: Irish Society of Immunology, Function/Role: Committee member | |||||||||
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| Patent 6,423,334 : Composition and method for enhancing transport across gastrointestinal tract cell cultures |
| Patent 2002/0009466 A1 : Oral vaccine compositions |
| Patent PCT IE99/00086 : Method for inducing a cell-mediated immune response and imporved parenteral vaccine formulations thereof |
| Patent WO 02/080852 : Genetic analysis of Peyer's patches and M cells and methods and compositions targeting Peyer's patch and M cell receptors |
| Patent USP : Compositions and methods for preventing amyloidogenic disease |
| Patent 10/869,266 : Mucoadhesive and bioadhesive polymers | |||||||||
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| Keely, S., Wilson C., Carrinton S., Rullay A.K., Haddleton D.M., Brayden, D.J.; (2004) An In Vitro Intestinal Model for the assessment and ranking of polymer mucoadhesion. [Oral Presentation], 6th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Welsh School of Pharmacy, Cardiff University , 07-JAN-04 - 09-JAN-04. |
| Keely, S., Rullay, A., Wilson, C., Carrington, S., Haddleton, D., Brayden, D.; (2004) The effect of quaternisation on the adhesionof a novel hydrophilic polymer. [Poster Presentation], Controlled Release Society, Summer Meeting 2004, Hawaii, U.S.A , 12-JUN-04 - 16-JUN-04. |
| Rullay AK., Haddleton DM., Keely S., Carrington S., Brayden D.; (2004) Novel Fluorescently-labelled hydrophilic polymers for mucoadhesion: potential therapeutics. [Oral Presentation], 6th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Welsh School of Pharmacy, Cardiff University , 07-JAN-04 - 09-JAN-04. |
| Keely S., Wilson C., Carrington S., Brayden D.; (2004) In vitrous Mucous-Secreting Intestinal Models for Polymer Adhesion. [Poster Presentation], 2nd Annual Bionet Conference, IT,Carlow , 15-DEC-04 - 16-DEC-04. |
| Keely, S., Rullay, A., Wilson, C., Carrington, S., Haddleton, D., and Brayden, D.; (2004) Comparison of Intestinal Cell Cultre and Excised Tissue Models for Examining the Interaction of a Hydrophilic Polymer. [Poster Presentation], Conway Festival of Research, Conway Institute, University College Dublin , 19-SEP-04 - 19-SEP-04. |
| Keely, S., Wilson, C., Carrington, S., and Brayden, D.; (2005) In Vitro Mucous-Secreting Intestinal Models for Polymer Adhesion. [Oral Presentation], BionNet Conference December 2004, Carlow, Ireland , 15-DEC-05 - 15-DEC-05. | |||||||||
| Fletcher N.F., Brayden D.J., Brankin B., Worrall S & Callanan J.J. ; (2005) Growth and characterisation of a feline in vitro blood-brain barrier. [Invited Oral Presentation], 23rd Meeting of the European Society of Veterinary Pathology,, Naples Italy , 07-SEP-05 - 09-SEP-05. | |||||||||
| Feighery, L., Keely, S., Smyth, A., Callanan, J., Baird, A., O'Connor, W., and Brayden, D.,; Demonstration of compromised ileal structure and function folflowing severe acute head trauma in rats. [Poster Presentation], Conway Festival of Research, U.C.D. 2004, Conway Institute, U.C.D . | |||||||||
| Workshop Organiser; (2008) Chair, Workshop on Biological Assessment of Polymeric Conjugates. [Conference Organising Committee Chairperson], Controlled Release Society Conference, New York 2008, New York , 12-JUL-08 - 14-JUL-08. | |||||||||
| Griffin, J., Blanchflower, S. & Brayden, D. J.; (2004) Interactions of avermectins with human and canine P-glycoprotein transporters. [Invited Oral Presentation], Proc. Intern. Symp. Control. Rel. Bioact. Mater.,, Hawaii , 18-JUN-04 - 22-JUN-04. | |||||||||
| Brayden, D. J.; (2003) Mucosal vaccines: a special kind of peptide delivery. [Invited Oral Presentation], Protein Delivery 2003, Royal Pharmaceutical Society of GB , 25-NOV-03 - 26-NOV-03. | |||||||||
| Brayden, D.J.; (2003) Oral peptide delivery: human. [Invited Oral Presentation], Controlled Release Society, 2003, Glasgow, Scotland , 19-JUN-03 - 23-JUN-03. | |||||||||
| Brayden, D.J; (2002) Human drug delivery: uses in veterinary medicine. [Invited Oral Presentation], AAPS Workshop on collaboration in R & D of Veterinary Pharmaceuticals, Chicago, USA , 06-APR-02 - 09-APR-03. | |||||||||
| Brayden, D.J.; (2001) Novel approaches for in vitro and in situ modelling of human intestinal Peyer's patches. [Invited Oral Presentation], CRS Workshop on Mucosal Immunisation, San Diego, USA , 25-JUN-01 - 30-JUN-01. | |||||||||
| Brayden, D.J.; (2001) Non-injected vaccine delivery: of particles and patches. [Invited Oral Presentation], Cost 820: vaccination for coccidiosis, Dublin , 10-JUN-01 - 11-JUN-01. | |||||||||
| *; (2001) *. [Conference Organising Committee Chairperson], CRS UKI Annual Meeting, Queen's University Belfast , 10-JAN-01. | |||||||||
| Brayden, D.J.; (2000) PLGA-entrapped antigens as a viable oral delivery systmem. [Conference Organising Committee Chairperson], CRS-UKI Special Symposium on novel vaccine formulations and delivery systems, Trinity College , 04-JAN-00 - 06-APR-00. | |||||||||
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| Committee : UCD Tenure and Promotions Committee (UCAAPT) |
| Committee : SAFVM Research Committee |
| Committee : School of Agriculture, Food Science and Veterinary Medicine Executive |
| Committee : SAFVM Management Committee |
| Committee : Veterinary Faculty Research Committee |
| Committee : UCD Research Ethics (REC) | |||||||||
| Committee : University Animal Ethics Committee, Chairman | |||||||||
| Committee : President's Research Strategy Board | |||||||||
| Committee : UK-Ireland Controlled Release Society | |||||||||
| Committee : Board of Science Advisors, Controlled Release Society | |||||||||
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| Employer: University of Cambridge Position: Research Assisant |
| Employer: Stanford University Position: Post-doctoral research Fellow |
| Employer: Elan Biotechnology Research Position: Senior Scientist / Programme Manager |
| Employer: University College Dublin Position: Associate Professor |
| Year 1985 Institution: University College Dublin Qualification: MSc Subject: |
| Year 1987 Institution: University of Cambridge Qualification: M.Phil. Subject: Pharmacology |
| Year 1989 Institution: University of Cambridge Qualification: PhD Subject: Pharmacology |
| Year 1984 Institution: University College Dublin Qualification: BSc(Pharm) Subject: |
| Client: : Novo-Nordisk |
| Secondary School talks on drug delivery as part of Cluster outreach |
| Seminars given to industrial bioech scientists on novel non-injected ways to deliver recombinant molecules (2001-present) |
| Professor Alan W. Baird Professor Sean Callanan |
| Professor Padraic Fallan (TCD) Professor Randall Mrsny (U. Bath) Professor Caitriona O'Driscoll (UCC) Professor David M. Haddleton (U. Warwick) Professor Andreas Heise (DCU) Professor Maria-Jose Alonso (U. Compostella) Merrion Pharmaceuticals Sigmoid Pharmaceuticals Novo Nordisk |
| My best teaching draws on nearly 30 years of pharmaceutical research experience and I try to generate enthusiasm whenever I am interacting with students. It's all about stimulating students to go off and read around up-to-date lecture material to re-inforce concepts of pharmacology, drug discovery and drug delivery. |
| 201100 PHAR40090 Pharmacology: Integrated Pharmacology |
| 201100 PHAR40050 Pharmacology: Drug Discovery and Development |
| 201100 VET20040 Veterinary Medicine: Biological Fluids |
| I have used my professional network in the pharmaceutical industry to access role models for students in terms of the career paths some of these successful people have taken. High performing executives from the industry and venture capital companies contribute to my Drug Discovery courses and I chair these interactions. Students respect graduates who have taken successful career paths. I have also brought the British Pharmacology Society's 'pharmaCALogy' computer-assisted learning to UCD by which students across UCD perform CALs in moderated sessions and I am currently beta testing the new suite of BPS programmes 'Prescribe.' Research shows that student learning from pharmacology CALs matches that of surgical practical except for few honours pharmacology students where hands-on experience is a requirement for a career in pharmacology research. Finally, I carefully assess curriculum content every year to update and replace and this applies to core texts. In terms of delivery technique, conference attendee feedback on my research talks is really informative and detailed and I am always seeking to ensure I am communicating well in terms of slide design, content, timing and use of alternative media. Student feedback is assessed on my modules and changes are frequently by me made in response to valid comment. My teaching has been observed by peers in joint lectures and staff are always happy to share notes on what works and what does not. |
| The Vet School analyses external examiner feedback very closely and sets a lot of store by their reports. The Vet degree is professionally accredited so currulum content is set down for the most part. The vets have to learn certain pharmacological concepts that do not change, so I have to ensure good balance and to freshen presentation of material every year. I am looking to teach more material in Veterinary Therapeutics for Vets in their clinical years. In 2012, the Vet Heads of Subject met to ensure that there was minimal duplication across Vet modules. In my science teaching, it is closely aligned to my research strengths and I had a free hand to construct the main Drug Discovery module and to assemble lecturing support. This was the first time this had been taught at UCD and the course grows every year in terms of take up from all parts of Science and Medicine. It is enhanced because every year I have case studies of drugs approved that year by the FDA and many students will be aware of some of them from the media. I teach Continuing Professional Development to pharma companies and to the Vet community (online module)and this material requires particular vigilance; the knock-on benefit is that I can then use some of it for undergraduate teaching. |
| The Vet School and the Centre for Teaching and Learning provide workshops on best practice which I attend occasionally. However, since my research is the main focus of my UCD work and given my obligations to funding agencies, I am limited timewise to attending just a few courses, compared to many staff in this regard. Still, I love to take inspection copies of new texts to see if I can bring them into my courses and I am always looking for new teaching material from conferences I attend. I am 11 years in UCD and my teaching has improved as I am better at realising what level and quantity of material can be understood by the majority of the class. However, it's only when I examine scripts that I can see if I have succeeded ! Also, I have been an external examiner at top vet schools at Glasgow and London and am currently extern on pharmaceutics courses at DIT and I like to compare their curricula with UCD's and also to assess the achievements of their students with ours. This helps me set my own teaching standards for my courses at UCD. |
| A key goal is to use the latest texts and online technology to renew current material and design new modules for a range of groups. These include vet, medicine, and science undergrads, as well as 4th Level in UCD and Molecular Medicine Ireland. I also provide continuing professional development for the pharma industry and vet profession. |
