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Evelyn Murphy

Associate Professor and Fellow

Conway Institute of Biomolecular & Biomedical Research

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Biography

2014-present: Associate Professor, Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Ireland.

2011-2013: Section Head, Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Ireland.

2006-2013: Senior Lecturer and Conway Fellow, College of Life Sciences, University College Dublin, Belfield, Ireland.

2002-2006: Lecturer, Department of Veterinary Biochemistry and Physiology, University College Dublin, Belfield, Ireland.

2000-2002: Research Lecturer, Department of Rheumatology, St Vincent's University Hospital, Ireland.

1997-2000: Newman Scholar, Department of Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland.

1993-1997 Post-Doctoral Fellow, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA.

Professional

Honours and Awards

Year: 2001.
Title: JMS/HRB Award
Year: 2001.
Title: European (EULAR) Young Investigator Award
Year: 2003.
Title: Presidents Research Award
Year: 2009.
Title: SFI Principal Investigator Programme Award
 

Patents

Patent PCT US 01/15311 : Therapeutic approaches to disease by suppression of the NURR subfamily of nuclear transcription factors
   

Conference Contributions

Evelyn Murphy (2014) Adenosine signalling through the NR4A subfamily of orphan nuclear receptors. [Invited Oral Presentation], Purines 2014, Bonn, Germany , 23-JUL-14 - 27-JUL-14.
Smyth AM, Aherne C, Crean D and Murphy EP (2013) Differential expression of AMPK, PGC1a and NR4A2 in inflammatory arthritis. [Refereed Abstracts], Cell ImmunoMetabolism, Toronto, Canada , 08-JUN-13 - 12-JUN-13.
Gilmore A and Murphy EP; (2012) Role of histamine in regulating cartilage homeostasis. [Oral Presentation], European Histamine Research Society, Belfast , 05-FEB-12 - 05-MAY-12.
Evelyn Murphy; (2001) Orphan nuclear receptor control gene expression during inflammation. [Invited Oral Presentation], Joint Irish and British Society of Rheumatology Annual meeting, Ireland , 12-OCT-01.
Murphy EP; (2010) NR4A orphan nuclear receptors and inflammation. [Invited Oral Presentation], Biochemical Society, Belfast , 25-NOV-10 - 26-NOV-10.
Murphy EP; (2006) Nuclear receptors are important transcriptional regulators of inflammation. [Invited Oral Presentation], Joint Irish and British Society of Rheumatology, University College Dublin , 15-SEP-06.
Mix K, Murphy EP; (2005) Regulation of MMPs in cartilage by the nuclear recptor NURR1. [Oral Presentation], American College of Rheumatology, San Diego. USA , 12-NOV-05 - 17-NOV-05.
Aherne C and Murphy EP; (2005) Interleukin 8 is a transcriptional target of the nuclear receptor NURR1. [Oral Presentation], American College of Rheumatoloy, San Diego. USA , 12-NOV-05 - 17-NOV-05.
Gogarty M, Murphy EP et al.; (2005) VEGF and VEGF receptor expression in human inflammatory arthritis. [Poster Presentation], American College of Rheumatology, San Diego. USA , 12-NOV-05 - 17-NOV-05.
Murphy E.; (2001) The Hypothalamic-Pituitary-Adrenal Axis and Inflammation. [Invited Oral Presentation], 2nd International Meeting on the Neuroendocrine Immune Basis of Rheumatic Disease, Genoa. Italy , 19-SEP-01.
Murphy E.; (2002) The nuclear orphan receptor NURR1 is a mediator of CRH responses in vascular enothethelium. [Invited Oral Presentation], Keystone Symposium on the Nuclear Receptor Superfamily, Snowbird, Utah, USA , 20-MAR-02.
Murphy E.; (2003) Angiogenic Mediators. [Invited Oral Presentation], Section of Clinical Immunology and Allergy of the Royal Society of Medicine, University College Dublin , 01-MAY-03.
Aherne C, Mix K and Murphy EP; (2005) Cytokine modulation of the orphan nuclear receptor NURR1. [Poster Presentation], EMBO Conference on Nuclear Receptors, Milan, Italy , 28-OCT-05 - 02-NOV-05.
Mix K, Brinckerhoff C and Murphy EP; (2005) Modulation of MMP expression in cartilage. [Poster Presentation], EMBO Conference on Nuclear Receptors, Milan, Italy , 28-OCT-05 - 02-NOV-05.
Ralph J and Murphy EP; (2004) CRH mediates vascular changes in human inflammatory arthritis. [Poster Presentation], American College of Rheumatology, San Antonio, Houston. Texas , 28-OCT-04 - 01-NOV-04.

Committees

Committee : Research Committee, School Veterinary Medicine
Committee : School of Veterinary Medicine Research Committee
Committee : School Executive, School of Veterinary Medicine
Committee : MVB Student Progress Committee
Committee : Committee for Postgraduate Studies

Employment

Employer: Baylor College of Medicine Texas
Position: Post Doctoral Fellow
Employer: University College Dublin
Position: Newman Scholar
Employer: St Vincent`s University Hospital
Position: Research Lecturer
Employer: University College Dublin
Position: Lecturer

Education

Year 1993 Institution:
Qualification: PhD Subject:
   

Outreach Activities

Currently participate in
Summer Intern Programme with
the Ecole de Biologie Industrielle, Paris and
 Veterinary Medicine School initiative for transition year students (15-16 year olds) 

 

   

Publications

 

Book Chapters

Eijbouts A, E. Murphy E.; (1999) 'The role of the hypothalmic-pitutary adrenal axis in patients with rheumatoid arthritis' In: * (eds). Ballieres Clinical Rheumatology. , pp.599-613 [Details]
 

Peer Reviewed Journals

McEvoy C, de Gaetano M;Giffney HE;Bahar B;Cummins EP;Brennan EP;Barry M;Belton O;Godson CG;Murphy EP;Crean D (2017) 'NR4A Receptors Differentially Regulate NF-¿¿B Signaling in Myeloid Cells'. Frontiers in Immunology, 8 . [DOI] [Details]
McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP and Crean D (2017) 'Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells'. Frontiers in Immunology, 8 (7). [DOI] [Details]
Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP (2015) 'Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells'. Journal of Immunology, 195 (4):1436-1448. [DOI] [Details]
Murphy EP, Crean D (2015) 'Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-kB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis'. Biomolecules, 5 (3):1302-1318. [DOI] [Details]
McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, Murphy EP (2013) 'Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity'. Pathology, 183 (4):1243-1257. [DOI] [Details]
Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy EP, Brayden D, Veale DJ, Fearon U. (2014) 'Redox mediated angiogenesis in the hypoxic joint of inflammatory arthritis'. Arthritis and Rheumatism, . [Details]
JP McMorrow, D Crean, M Gogarty, A Smyth, M Connolly, E Cummins, D Veale, U Fearon, PP Tak, O Fitzgerald, and EP Murphy (2013) 'Tumour Necrosis Factor inhibition modulates Thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity'. American Journal of Pathology, 183 (4):1243-1257. [Details]
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ (2013) 'An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis'. Journal of controlled release : official journal of the Controlled Release Society, 167 (2):120-129. [Details]
Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP. (2012) 'The role of NR4A orphan nuclear receptors in cancer'. Clinical Cancer Research, 18 (12):3223-3228. [Details]
Mix KS, McMahon K, McMorrow JP, Walkenhorst D , Smyth AM, Petrella BL, Gogarty M, Fearon U, Veale D, Attur MG, Abramson SB and Murphy EP.; (2012) 'Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and MMP-13 transcription'. Arthritis and Rheumatism, 64 (7):2126-21236. [Details]
Marzaioli V, McMorrow JP, Angerer H, Gilmore A, Crean D, Zocco D, Rooney P, Veale D, Fearon U, Gogarty M, McEvoy AN, Stradner M and Murphy EP. (2012) 'Histamine contributes to increased RANKL/OPG ratio through altered NR4A activity in human chondrocyte cells'. Arthritis and Rheumatism, 64 (10):3290-3301. [Details]
McMorrow J and Murphy EP; (2011) 'Inflammation: a role for NR4A orphan nuclear receptors'. Biochemical Society Transactions, 39 (2):688-693. [Details]
Ralph, J.A., Ahmed, A.U., Santos, L.L., Clark, A., McMorrow, J., Murphy, E.P., Morand, E.F.; (2010) 'Identification of NURR1 as a Mediator of MIF Signalling During Chronic Arthritis: Effects on Glucocorticoid-Induced MKP1'. American Journal of Pathology, 177 (5):2366-2378. [Details]
Zocco D, McMorrow JP and Murphy EP; (2010) 'Histamine modulation of peripheral CH receptor 1a expression is dependent on calcium signalling and NF-kB/p65 transcriptional activity'. Molecular immunology, 47 :1426-1437. [Details]
Keely, S.,Ryan, S. M.,Haddleton, D. M.,Limer, A.,Mantovani, G.,Murphy, E. P.,Colgan, S. P.,Brayden, D. J.; (2009) 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers'. J Control Release, 135 (11):35-4335. Available Online [Details]
Brayden DJ, Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, ; (2009) 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers'. Journal of Controlled Release, 135 (1):35-43. [DOI] [Details]
Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS and Murphy EP. ; (2009) ' Identification of the orphan receptor NR4A2 as a transcriptional regulator of IL-8 expression in human inflammatory arthritis'. Molecular immunology, 46 :3345-3357. [Details]
O'Kane, M., T. Markham, A. McEvoy, U. Fearon, D. Veale, O. FitzGerald, B. Kirby and E. Murphy; (2008) 'Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-α inhibition'. Journal of Investigative Dermatology, 128 :300-310. [Details]
Anquetin G, Rawe SL, McMahon K, Murphy EP, Murphy PV.; (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry-A European Journal, 14 (5):1592-1600. [Details]
Ralph, JA, Zocco, D, Bresnihan, B, FitzGerald, O, McEvoy, AN, Murphy, EP, ; (2007) 'A role for type 1 alpha corticotropin-releasing hormone receptors in mediating local changes in chronically inflamed tissue'. American Journal of Pathology, 170 :1121-1133. [Details]
Fitzgerald, D.C., Meade, K.G., McEvoy, A.N., Lillis, L., Murphy, E.P., Machugh, D.E., Baird, A.W.; (2007) 'Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells'. Veterinary Immunology and Immunopathology, 116 (1/2):59-68. [Details]
O'Kane, M; Kirby, B; Fitzgerald, O; Mcevoy, A; Murphy, EP; ; (2006) 'Altered expression of corticotropin-releasing hormone, corticotropin-releasing hormone receptor and NURR1 in psoriasis'. British Journal of Dermatology, 155 (NA):30-30. [Details]
Mix, K., Mukundan, G., Al-Mussawir, H., Abramson, S.B., Brinckerhoff, C.E. and Murphy, E. ; (2007) 'Transcriptional regulation of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage'. Journal of Biological Chemistry, 282 (13):9492-9504. [Details]
Rawe SL, Doyle D, Zaric V, Rozas I, McMahon K, Tosin M, Bunz HM, Murphy EP, O' Boyle KM, Murphy PV.; (2006) 'N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (10):370-390. [Details]
O'Kane, M., Murphy, E.P. & Kirby, B.; (2006) 'The role of Corticotropin Releasing Hormone in immune-mediated cutaneous disease'. Experimental Dematology, :143-153. [Details]
O'Kane, M; Murphy, E; Fitzgerald, O; Kirby, B; ; (2006) 'Corticotropin-releasing hormone (CRH), CRH receptor (CRH-R) and NURR1 are increased in psoriasis, further evidence of a brain-skin axis?'. British Journal of Dermatology, 154 (1). [Details]
O'Kane, M; Kirby, B; FitzGerald, O; McEvoy, A; Murphy, E; ; (2006) 'Corticotropin-releasing hormone, corticotropin-releasing hormone receptor and NURR1 are increased in psoriasis lesional skin'. British Journal of Dermatology, 155 (1):254-255. [Details]
Ralph J, McEvoy A, Kane D, Bresnihan B, FitzGerald O and Murphy E.P.; (2005) 'Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor mediated responses'. Immunology, 55 :555-565. [Details]
Mix, KS; Brinckerhoff, CE; Murphy, EP; ; (2005) 'Orphan nuclear receptor NURR1 represses matrix metalloproteinase-1 transcription in chondrocytes'. Arthritis and Rheumatism, 52 (9):706-706. [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E.; (2004) 'COX-2-derived prostaglandin E2 production by CRH contributes to the activated cAMP Response Element Binding Protein (CREB) content in Rheumatoid Arthritis synovial tissue'. Arthritis and Rheumatism, 50 :1132-1145. [Details]
OHara R, Murphy E, Whitehead A.S., FitzGerald O. and Bresnihan B.; (2004) 'Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis'. Arthritis and Rheumatism, 50 :1781-1787. [Details]
Benito MJ, Murphy E, Murphy E, FitzGerald O, van den Berg W, Bresnihan B.; (2004) 'Increased NF-kB1 (p50) expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis'. Arthritis and Rheumatism, 50 :1788-1799. [Details]
O'Kane, M; Kirby, B; Fitzgerald, O; Veale, D; Markham, T; Murphy, E; ; (2004) 'Corticotropin-releasing hormone - a possible role in psoriasis'. British Journal of Dermatology, 151 (NA):49-49. [Details]
Ralph, JA; McEvoy, AN; Bresnihan, B; FitzGerald, O; Murphy, EP; ; (2004) 'Inhibitory effects of low-dose methotrexate on expression of the orphan receptor NURR1 are mediated through the adenosine type A2 receptor'. Arthritis and Rheumatism, 50 (9):568-568. [Details]
McEvoy, AN; Bresnihan, B; FitzGerald, O; Murphy, EP; ; (2004) 'Cyclooxygenase 2-derived prostaglandin E-2 production by corticotropin-releasing hormone contributes to the activated cAMP response element binding protein content in rheumatoid arthritis synovial tissue'. Arthritis and Rheumatism, 50 (4):1132-1145. [Details]
Gallagher, J,Howlin, J,McCarthy, C,Murphy, EP,Bresnihan, B,FitzGerald, O,Godson, C,Brady, HR,Martin, F; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Letters, 551 (NA):8-12. [DOI] [Details]
Ralph, JA; Bresnihan, B; FitzGerald, O; Murphy, EP; ; (2003) 'Methotrexate inhibits the production of the transcription factor NURR1 in human inflammatory joint disease'. Arthritis and Rheumatism, 48 (9):417-417. [Details]
McEvoy A., Bresnihan B, FitzGerald O and Murphy E.; (2002) 'Corticotropin-Releasing Hormone signaling in vascular endothelium is mediated through the cAMP/CREB pathway'. Annals of the New York Academy of Sciences, 966 :119-130. [Details]
McEvoy A, Conneely O.M., Bresnihan B., FitzGerald O and Murphy E.; (2002) 'Activation of nuclear orphan receptor NURR1 transcription by NFkB and CREB in rheumatoid arthritis synovial tissue'. Immunology, 168 :2979-2987. [Details]
Murphy E, McEvoy A, Conneely OM, Bresnihan B and Fitzgerald O.; (2001) 'Involvement of the nuclear orphan receptor NURR1 in the regulation of Corticotropin Releasing Hormone expression and actions in human inflammatory arthritis'. Arthritis and Rheumatism, 44 :782-793. [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E.; (2001) 'Corticotropin Releasing Hormone (CRH) signaling in synovial tissue from patients with early inflammatory arthritis is mediated by the type 1a CRH receptor'. Arthritis and Rheumatism, 44 :1761-1767. [Details]
R OHara, EP Murphy, A S Whitehead, O FitzGerald, B Bresnihan.; (2000) 'Acute phase serum amyloid A production by rheumatoid arthritis synovial tissue'. Arthritis Care and Research, 2 :142-144. [Details]
Eijsbouts A and Murphy E.; (1999) 'The role of the Hypothalamic-Pituitary-Adrenal axis in Rheumatoid Arthritis'. Ballieres Clinical Rheumatology, 13 :599-613. [Details]
Murphy E. and Conneely O.M.; (1997) 'Neuroendocrine regulation of the Hypothalamic Pituitary Adrenal Axis by the NURR1/NUR77 subfamily of nuclear receptors'. Molecular Endocrinology, 16 :39-47. [Details]
Murphy E., Dobson A.D.W., Keller C. and Conneely O.M.; (1996) 'Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors'. GENE EXPRESSION, 5 :169-179. [Details]
Pontifex, E; Gogarty, M; Murphy, E; Bresnihan, B; Veale, D; FitzGerald, O; ; (2006) 'JunB expression in psoriatic arthritis synovium and skin pre- and post-treatment with etanercept'. Arthritis and Rheumatism, 54 (9):466-466. [Details]
 

Conference Publications

Gogarty, M., Murphy, E.P., Veale, D., Bresnihan, B., FitzGerald, O.; Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis ARTHRITIS AND RHEUMATISM [Details]
Aherne, C.M., Mix, K.S. & Murphy, E.P.; Modulation of the transcriptional activity of the nuclear receptor NURR1 by pro-inflammatory mediators ARTHRITIS AND RHEUMATISM [Details]
Irwin JA, Murphy EP, Gallagher ME, Ryan MT, Gaines S, McMahon M (2013) Biochemistry teaching in veterinary medicine: the UCD experience Veterinary Education Symposium 2013 [Details]
McMorrow, JP,Murphy, EP (2011) BIOCHEMICAL SOCIETY TRANSACTIONS Inflammation: a role for NR4A orphan nuclear receptors? , pp.688-693 [DOI] [Details]
Viviana Marzaioli, Jason P. McMorrow, Alice McEvoy and Evelyn P. Murphy.; (2010) Histamine contributes to inflammatory joint disease by regulating the expression of RANKL and OPG through altered NR4A activity in human chondrocyte cells Arthritis and Rheumatism 62 (10)1482, , pp.1482 [Details]
Jason P. McMorrow, Ursula Fearon, Douglas Veale, Oliver Fitzgerald and Evelyn P. Murphy.; (2010) Contribution of NR4A2 Gene Expression in the Modulation of Thrombospondin-1 in Human Joint Disease Arthritis and Rheumatism 62 (10) 1508, , pp.1508 [Details]
Jason P. McMorrow, Evelyn P. Murphy, Bruce N. Cronstein.; (2010) Identification of the NR4A family of orphan nuclear receptors as mediators of adenosine A2A receptor activation Arthritis and Rheumatism 62(10)1522, , pp.1522 [Details]
Ryan, S. M., McMorrow, J. P., Murphy, E. P. & Brayden, D. J.; (2010) Salmon calcitonin reduces expression of a novel biomarker family in inflammatory arthritis:a new target for controlled release formulations? Transactions of the 37th Int. Soc. Controlled Release Society, Portland, Oregon , pp.Abstract 24 [Details]
Ryan, SM, McMorrow, J., Murphy, E.P. & Brayden, D. J. ; (2009) Salmon calcitonin as a potential therapeutic for osteoarthritis and rheumatoid arthritis 36th Int. Soc. Controlled Release Society, Copenhagen, Denmark , pp.Abstract 450 [Details]
Ryan SM, McMorrow JP, Murphy EP and Brayden DJ; (2009) Salmon calcitonin as a potential therapeutic for osteoarthritis and rheumatoid arthritis Proc. Intern. Symposium. Control. Rel. Bioact. Mat , pp.36, 91 [Details]
McMorrow, J. P., Murphy, E. P., ; (2008) Journal of Neuroimmunology Transcriptional repression of thrombospondin-1 gene expression by NR4A2 in inflammatory joint disease , pp.172-172 [Details]
Zocco, D., Murphy, E. P., ; (2008) Journal of Neuroimmunology Histamine modulates the expression of corticotrophin-releasing-hormone receptor type I in human inflammatory arthritis , pp.171-171 [Details]
Gogarty, M., Murphy, E. P., Fearon, U., Veale, D. J., Bresnihan, B., FitzGerald, O., ; (2007) Annals of the Rheumatic Diseases Abundant placenta growth factor (PlGF) expression in the inflammatory joint , pp.141-141 [Details]
Gogarty, M, Murphy, EP, Fearon, U, Veale, DJ, Bresnihan, B, FitzGerald, O, ; (2007) ANN RHEUM DIS Placenta growth factor (PLGF) expression in inflammatory arthritis , pp.35-36 [Details]
O'Kane, M., Kirby, B., FitzGerald, O. & Murphy, E.P.; (2006) Corticotropin-releasing hormone, corticotropin-releasing hormone receptor and NURR1 are increased in psoriasis lesional skin British Journal of Dermatology , pp.155 (1): 254-255 [Details]
Mix, K.S., Brinckerhoff, C.E. & Murphy, E.P.; (2005) Orphan nuclear receptor NURR1 represses matrix metalloproteinase-1 transcription in chondrocytes ARTHRITIS AND RHEUMATISM , pp.(9): S706-S706 [Details]
Aherne, C.M., Mix, K.S. & Murphy, E.P.; (2005) Modulation of the transcriptional activity of the nuclear receptor NURR1 by pro-inflammatory mediators ARTHRITIS AND RHEUMATISM 52 (9): S707-S708, [Details]
Gogarty, M., Murphy, E.P., Veale, D., Bresnihan, B., FitzGerald, O.; (2005) Alternative splicing of the VEGFR-1 (flt-1) and its ligands in human inflammatory arthritis ARTHRITIS AND RHEUMATISM , pp.S52-S52 38 [Details]
Ralph J, McEvoy A, Kane D, Bresnihan B, FitzGerald O and Murphy E; (2004) Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor mediated responses ARTHRITIS AND RHEUMATISM , pp.46 (9): 740 [Details]
Ralph JA, McEvoy AN, Bresnihan B, FitzGerald O and Murphy E. ; (2002) Modulation of type 1 CRH receptor expression by inflamed human synovial tissue: Involvement in the pathological changes associated with increased vascular permeability ARTHRITIS AND RHEUMATISM , pp.45 (9): 740 [Details]
McEvoy A, Bresnihan B, FitzGerald O and Murphy E. ; (2002) COX-2-derived prostaglandin E2 production by CRH contributes to the activated cAMP Response Element Binding Protein (CREB) content in Rheumatoid Arthritis synovial tissue ARTHRITIS AND RHEUMATISM , pp.45 (9): 740 [Details]
                       

Abstract

Gilmore, A,Marzaioli, V,McMorrow, JP,Angerer, H,Crean, D,Zocco, D,Rooney, P,Veale, D,Fearon, U,Gogarty, M,McEvoy, AN,Stradner, MH,Murphy, EP (2012) HISTAMINE CONTRIBUTES TO AN INCREASED RANKL/OPG RATIO THROUGH ALTERED NR4A ACTIVITY IN HUMAN CHONDROCYTE CELLS. Abstract [Details]
                                                                                       

Research

Research Interests

Pathogenesis of inflammatory disease

1. Chronic or inappropriate inflammatory responses contribute to the pathogenesis of several diseases including psoriasis and arthritis.  Important scientific advances indicate that the progression of these diseases may result from a switch in the type of cells which are present at sites of inflammation which ultimately leads to damage and destruction of the affected tissue.  A major focus of this research programme is to understand the events and mechanisms involved in switching cells during the inflammatory response. A thorough understanding of these processes may assist in the diagnosis of inflammatory disease and facilitate the introduction of effective treatments in the early stages of disease. The study of inflamed tissue and derived cells represents a central feature of this research programme which will provide information with important clinical significance. Furthermore, these studies may potentially open new avenues for the treatment of chronic inflammatory disease.

2. Long-term physiologic stress responses are achieved by integration of the autonomic nervous, HPA, cardiovascular, metabolic and immune protective responses. Achieving this dynamic stability requires considerable "tissue wear and tear" resulting from sustained overactivity (or underactivity) of these systems. Disturbances in endocrine-immune interactions upset the normal regulatory homeostatic balance and may alter susceptibility to a variety of disease states associated with immune dysregulation. Inflammatory stimuli reliably elicit HPA activation, and it is now established that the immune and HPA systems are mutually regulatory and that their interactions partly determine stress effects on immune function. What has not been extensively studied, however, is the interactive nature of the endocrine and immune systems and whether this might alter predisposition to inflammatory disease or stress-related pathologies. The long-term aim of this research programme is to further explore the physiological and molecular interactions occurring at the neuroendocrine-immune interface.

Key areas of interest include:

  • Acute and chronic inflammation
  • Cytokine action
  • Signal transduction
  • Orphan nuclear receptors
  • Gene transcription

Research Projects

Sponsor : University College Dublin (UCD)
Title : Metabolic dysregulation perpetuates inflammation and is mediated by AMPK/PGC1a signalling in joint disease
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : Science Foundation Ireland (SFI)
Title : TIDA Training proposal
Start Date / End Date : 01-JAN-12 / 31-DEC-12
Sponsor : Science Foundation Ireland (SFI)
Title : Functional analysis of NR4A receptor activity during distinct phases of acute and chronic inflammation
Start Date / End Date : 01-APR-10 / 30-SEP-15
Sponsor : Health Research Board (HRB)
Title : Regulation of matrix metalloproteinase gene expression by the orphan receptor NURR1
Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : Science Foundation Ireland (SFI)
Title : The contribution of NR4A2-dependent gene expression for the development of chronic inflammatory joint disease
Start Date / End Date : 01-JUL-07 / 30-JUN-10
Sponsor : Science Foundation Ireland (SFI)
Title : Functional Analysis of NR4A2 Activity in an Animal Model of Wound Repair
Start Date / End Date : 06-APR-09 / 05-JUL-09
Sponsor : Health Research Board (HRB)
Title : Effects of CRH receptor antagonism to reduce vascular permeability and cartilage degradation in human inflammatory joint disease
Start Date / End Date : 01-OCT-07 / 30-SEP-10
Sponsor : Health Research Board (HRB)
Title : Elucidating the molecular mechanisms of methotrexate action
Start Date / End Date : 01-OCT-05 / 30-SEP-08
Sponsor : University College Dublin (UCD)
Title : Elucidation if Orphan Nuclear Receptor Function
Start Date / End Date : 01-AUG-03 / 30-SEP-04
Sponsor : Health Research Board (HRB)
Title : Cortocotropin-releasing hormone-mediated responses in psoriasis
Start Date / End Date : 10-JUL-05 / 30-JUN-07
Sponsor : Science Foundation Ireland (SFI)
Title : Modulation of matrix metalloporteinase gene expression by the nuclear orphan receptor NURR1
Start Date / End Date : 01-OCT-04 / 15-MAR-08
Sponsor : Health Research Board (HRB)
Title : Understanding Nuclear Orphan Receptor Function
Start Date / End Date : 01-OCT-03 / 30-SEP-06
Sponsor : Health Research Board (HRB)
Title : The proinflammatory effects of corticotropin releasing hormone in human arthritis
Start Date / End Date : 01-OCT-01 / 30-SEP-04
Sponsor : Health Research Board (HRB)
Title : Modulation of the transcription factor nurri is a component of the inflammatory process in human arthritis
Start Date / End Date : 01-OCT-00 / 30-SEP-03
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 28-SEP-98 / 28-SEP-01

Recent Postgraduates

Postgraduate Teaching

Neuroimmunology: Long-term physiologic stress responses are achieved by integration of the autonomic nervous, hypothalamic-pituitary-adrenal  (HPA) axis, cardiovascular, metabolic and immune protective responses.  Achieving this dynamic stability requires considerable ¿tissue wear and tear¿ resulting from sustained overactivity (or underactivity) of these systems. Disturbances in endocrine-immune interactions upset the normal regulatory homeostatic balance and may alter susceptibility to a variety of disease states associated with immune dysregulation.  Inflammatory stimuli reliably elicit HPA activation, and it is now established that the immune and HPA systems are mutually regulatory and that their interactions partly determine stress effects on immune function.  In this lecture, we will discuss the interactive nature of the endocrine and immune systems and whether this might alter predisposition to inflammatory disease or stress-related pathologies.

Primary supervision of following postgraduate fellows and students

2011-2014      Dr Daniel Crean, Postdoctoral Fellow 
2006-2010      Dr Jason McMorrow, Postdoctoral Fellow
2004-2007      Dr Kim Mix, Postdoctoral Fellow
2005-2006      Dr Darren Ennis, Postdoctoral Fellow
2005-2007      Dr Marina O'Kane, MD Fellow
2002-2003      Dr Alice McEvoy, Postdoctoral Fellow

2011-2015      Aisling Smyth, PhD student
2010-2015      Alyssa Gilmore, PhD student
2007-2011      Viviana Marzaioli, PhD student
2005-2009      Davide Zocco, PhD student
2003-2007      Carol Aherne, PhD student
2001-2005      Jennifer Ralph, PhD student
1998-2002      Alice McEvoy, PhD student

 

Teaching

Teaching Philosophy

To create an active and rewarding environment for lifelong learning and scholarship for undergraduate students and graduate trainees.
       

Innovation & Leadership

I am fully committed to the concept of research-led teaching to bring to students new knowledge and understanding that reflects current theories, research and innovation. I believe that effective education leadership is essential in improving student learning and learning experiences at undergraduate and postgraduate levels.

Collaborators

Internal Collaborators


UCD Collaborators

Dr Jason McMorrow, School of Agriculture, Food Science and Veterinary Medicine.

Dr Sinead Ryan, School of Agriculture, Food Science and Veterinary Medicine.

Professor David Brayden, School of Agriculture, Food Science and Veterinary Medicine.

Professor Oliver FitzGerald, School of Medicine and Medical Sciences.

External Collaborators

Dr Alice McEvoy, School of Biology, Dublin Institute of Technology.

Professor Paul Murphy, School of Chemistry. National University Ireland-Galway.

Professor Bruce Cronstein, School of Medicine, New York University.
 
Professor Kim Mix, Department of Biological Sciences, Loyola University, New Orleans.