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Pieter Brama

Full Professor of Veterinary Surgery

School Of Veterinary Medicine
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166062
Email: pieter.brama@ucd.ie

Biography

Pieter Brama received his veterinary degree (DVM cum laude) from the

University of Utrecht in 1994. He followed his surgery residency at the

Department of Equine Sciences and became board certified as a Dutch

Specialist in Equine Surgery in 1998 (DRNVA). In 1999 he received his

PhD (cum laude) from Utrecht University for his thesis: Dynamics of

Equine Articular Cartilage. In 2000 he became board certified as a

Diplomate in the European College of Veterinary Surgeons (DECVS).

Pieter Brama continued working at the Department of Equine Sciences

until October 2006 when he moved to University College Dublin to take

the chair of Professor of Veterinary Surgery. He completed an MBA (1st Class

Honours) at the UCD Michael Smurfit Graduate Business School in 2011. 

He currently is the Head of Veterinary Clinical Sciences. 

Pieter's key clinical interests are lameness and surgery in general although his orthopaedic research have resulted in certain specific orthopedic interests like cartilage repair and joint disease.

Professional

                 

Languages

French:
German:
English:
Dutch:
       

Publications

Books

Brama PAJ; (1999) Dynamics of Equine Articular Cartilage. Utrecht: Addix Wijk bij Duurstede. [Details]

Book Chapters

Roberto Narcisi, Mairéad A. Cleary, Kavitha Sivasubramaniyan, Pieter A.J. Brama, Gerjo J.V.M. van Osch (2017) 'MSC Populations for Cartilage Regeneration' In: Herausgeber: Grässel, Susanne, Aszódi, Attila (eds). Cartilage Volume 3: Repair Strategies and Regeneration. Vienna, Austria: Springer Nature. [Details]
van Weeren, Rene; Brama, Pieter (2015) 'Effect of loading/exercise on articular tissues and developmental aspects of joints' In: C. Wayne McIIwraith, David D. Frisbie, Christopher E. Kawcak, P.Rene van Weeren (eds). Joint disease in the horse. St. Louis USA: Elsevier. [Details]
Brama PAJ; (2013) 'The response of musculoskeletal tissues to exercise' In: Clayton H. and Back W (eds). Equine Locomotion. Philidelphia: Saunders. [Details]
Brama PAJ; (2009) 'Osteochondrosis' In: Robinson and Sprayberry (eds). Current Therapy in Equine Medicine. St. Louis: Saunders Elsevier. , pp.512-518 [Details]
Brama PAJ, van Weeren PR ; (2005) 'Gewrichtsaandoeningen bij het paard' In: H. van der Kolk (eds). Diergeneeskundig Memorandum. Rijswijk: Gezamenlijke uitgave. [Details]
Van Weeren PR, Brama PAJ ; (2005) 'Physiology of growth and development' In: M. Jacobs (eds). The growing horse: nutrition and prevention of growth disorders. Wageningen: Wageningen Academic Publishers. [Details]
Van Weeren PR, Brama PAJ ; (2003) 'The importance of physical exercise and type of conditioning for the health of joints' In: A. Lindner (eds). Performance diagnosis of equine joints. essen: Arbeitsgruppe Pferd. , pp.13-26 [Details]
 

Peer Reviewed Journals

Kulmala KA, Pulkkinen HJ, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama PA, Mikkola MT, Korhonen RK, Jurvelin JS, Töyräs J (2012) 'Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage'. Cartilage, 3 (3):235-244. [DOI] [Details]
Cleary MA, Narcisi R, Albiero A, Jenner F, de Kroon LMG, Koevoet WJLM, Brama PAJ, van Osch GJVM (2017) 'Dynamic Regulation of TWIST1 Expression During Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells'. Stem Cells and Development, 26 (10):751-761. [DOI] [Details]
kiernan, ch; wolvius, eb; brama, paj; farrell, e (2017) 'The immune response to allogeneic differentiated mesenchymal stem cells in the context of bone tissue engineering'. Tissue Engineering - Part B: Reviews, . [DOI] [Details]
Moran CJ, Ramesh A, Brama PA, O'Byrne JM, O'Brien FJ, Levingstone TJ. (2016) 'The benefits and limitations of animal models for translational research in cartilage repair'. Journal of Orthopaedic Research, 3 (1). [DOI] [Details]
Levingstone TJ, Ramesh A, Brady RT, Brama PA, Kearney C, Gleeson JP, O'Brien FJ. (2016) 'Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints'. Biomaterials, :69-81. [DOI] [Details]
Cleary MA, Narcisi R, Focke K, van der Linden R, Brama PA, van Osch GJ. (2016) 'Expression of CD105 on expanded mesenchymal stem cells does not predict their chondrogenic potential'. Osteoarthritis and Cartilage, . [DOI] [Details]
Kiernan CH, Hoogduijn MJ, Franquesa M, Wolvius EB, Brama PA, Farrell E (2016) 'Allogeneic chondrogenically differentiated human mesenchymal stromal cells do not induce immunogenic responses from T lymphocytes in vitro'. Cytotherapy, 18 (8):957-969. [DOI] [Details]
Sanders RE, Kearney CM, Buckley CT, Jenner F, Brama PA (2015) 'Knot Security of 5 Metric (USP 2) Sutures: Influence of Knotting Technique, Suture Material, and Incubation Time for 14 and 28 Days in Phosphate Buffered Saline and Inflamed Equine Peritoneal Fluid'. Veterinary Surgery, :723-730. [DOI] [Details]
Jenner F(1), van Osch GJ(2), Weninger W(3), Geyer S(3), Stout T(4), van Weeren R(4), Brama P(5). (2015) 'The embryogenesis of the equine femorotibial joint: The equine interzone'. Equine Veterinary Journal, :620-622. [Details]
Cleary MA, van Osch GJ, Brama PA, Hellingman CA, Narcisi R (2015) 'FGF, TGFβ and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells'. Journal of tissue engineering and regenerative medicine, 9 (4):332-342. [DOI] [Details]
Narcisi R, Cleary MA, Brama PA, Hoogduijn MJ, Tüysüz N, ten Berge D, van Osch GJ. (2015) 'Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation'. Stem Cell Reports, :459-472. [DOI] [Details]
Jenner F, Närväinen J, de Ruijter-Villani M, Stout TA, van Weeren PR, Brama P (2014) 'Magnetic resonance microscopy atlas of equine embryonic development'. Equine Veterinary Journal, 46 (2):210-215. [DOI] [Details]
Koistinen AP, Halmesmäki EP, Iivarinen JT, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ, Isaksson H. (2014) 'Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters'. Experimental Gerontology, :46-53. [Details]
Jenner F, IJpma A, Cleary M, Heijsman D, Narcisi R, van der Spek PJ, Kremer A, van Weeren R, Brama P, van Osch GJ. (2014) 'Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos'. Stem Cells and Development, :1883-1898. [Details]
Kearney CM, Buckley CT, Jenner F, Moissonnier P, Brama PA (2014) 'Elasticity and breaking strength of synthetic suture materials incubated in various equine physiological and pathological solutions'. Equine Veterinary Journal, 46 (4):494-498. [DOI] [Details]
Petersen, JL,Mickelson, JR,Rendahl, AK,Valberg, SJ,Andersson, LS,Axelsson, J,Bailey, E,Bannasch, D,Binns, MM,Borges, AS,Brama, P,Machado, AD,Capomaccio, S,Cappelli, K,Cothran, EG,Distl, O,Fox-Clipsham, L,Graves, KT,Guerin, G,Haase, B,Hasegawa, T,Hemmann, K,Hill, EW,Leeb, T,Lindgren, G,Lohi, H,Lopes, MS,McGivney, BA,Mikko, S,Orr, N,Penedo, MCT,Piercy, RJ,Raekallio, M,Rieder, S,Roed, KH,Swinburne, J,Tozaki, T,Vaudin, M,Wade, CM,Mccue, ME (2013) 'Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds'. PLoS Genetics, 9 . [DOI] [Details]
Rautiainen J, Lehto LJ, Tiitu V, Kiekara O, Pulkkinen H, Brünott A, van Weeren R, Brommer H, Brama PA, Ellermann J, Kiviranta I, Nieminen MT, Nissi MJ (2013) 'Osteochondral repair: evaluation with sweep imaging with fourier transform in an equine model'. Radiology, 269 (1):113-121. [DOI] [Details]
Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME (2013) 'Genetic diversity in the modern horse illustrated from genome-wide SNP data'. PLoS ONE, 8 (1). [DOI] [Details]
Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., Brama, P. A. (2013) 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10'. Animal Genetics, 44 (4):408-12. [Details]
Henderson IS, Brama P, Osborne M, Beltman ME. (2012) 'Interovulatory intervals in mares receiving deslorelin implants in Ireland (2009 to 2010)'. Veterinary Record, 170 (21):541. Link to full text [Details]
David, F,Cadby, J,Bosch, G,Brama, P,van Weeren, R,van Schie, H (2012) 'Short-term cast immobilisation is effective in reducing lesion propagation in a surgical model of equine superficial digital flexor tendon injury'. Equine Veterinary Journal, 44 :570-575. [DOI] [Details]
Virén T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brünott A, Brommer H, Van Weeren R, Brama PA, Zheng YP, Jurvelin JS, Töyräs J. (2012) 'Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage'. Journal of Medical Engineering & Technology, 36 (3):185-192. [DOI] [Details]
Närhi T, Siitonen U, Lehto LJ, Hyttinen MM, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ, Julkunen P (2011) 'Minor Influence of Lifelong Voluntary Exercise on Composition, Structure, and Incidence of Osteoarthritis in Tibial Articular Cartilage of Mice Compared with Major Effects Caused by Growth, Maturation, and Aging'. Connective Tissue Research, 52 :380-392. [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JAM, MacHugh DE, Ennis S, Hill EW, Brama PAJ ; (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Animal Genetics, 41 (suppl. 2):2-7. Available Online [DOI] [Details]
Kearney CM, Weeren van PR, Cornelissen BPM, Boon den P, Brama PAJ; (2010) 'Which anatomical region determined a positive lower limb flexion test in the sound horse'. Equine Veterinary Journal, 42 (6):547-551. [Details]
Julkunen P, Iivarinen J, Brama PA, Arokoski J, Jurvelin JS, Helminen HJ; (2010) 'Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits'. Osteoarthritis and Cartilage, 18 (3):406-415. [DOI] [Details]
Julkunen P, Halmesmäki EP, Iivarinen J, Rieppo L, Närhi T, Marjanen J, Rieppo J, Arokoski J, Brama PA, Jurvelin JS, Helminen HJ; (2010) 'Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters'. Journal of Anatomy, 217 (3):262-274. [Details]
Isaksson, H,Harjula, T,Koistinen, A,Ivarinen, J,Seppanen, K,Arokoski, JPA,Brama, PA,Jurvelin, JS,Helminen, HJ; (2010) 'Collagen and Mineral Deposition in Rabbit Cortical Bone during Maturation and Growth: Effects on Tissue Properties'. Journal of Orthopaedic Research, 28 :1626-1633. [DOI] [Details]
Kobrina, Y,Isaksson, H,Sinisaari, M,Rieppo, L,Brama, PA,van Weeren, R,Helminen, HJ,Jurvelin, JS,Saarakkala, S; (2010) 'Infrared spectroscopy reveals both qualitative and quantitative differences in equine subchondral bone during maturation'. Journal of Biomedical Optics, 15 . [DOI] [Details]
van Weeren, PR,Firth, EC,Brama, PAJ; (2010) 'To move or to perish: the importance of exercise during musculoskeletal development in the horse'. Pferdeheilkunde, 26 :581-587. [Details]
Brama, PAJ,Holopainen, J,van Weeren, PR,Firth, EC,Helminen, HJ,Hyttinen, MA; (2009) 'Effect of Loading on the Organization of the Collagen Fibril Network in Juvenile Equine Articular Cartilage'. Journal of Orthopaedic Research, 27 :1226-1234. [DOI] [Details]
Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppänen K, Närhi T, Arokoski J, Lammi MJ, Brama PA, Jurvelin JS, Helminen HJ; (2009) 'Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage. Osteoarthritis Cartilage'. Osteoarthritis and Cartilage, 17 (12):1628-1638. [Details]
Grauw de JC, Lest van de CHA, Brama PA, Rambags BPB, Weeren van PR; (2009) 'In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis'. Equine Veterinary Journal, 41 (1). [Details]
Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ; (2009) 'Physical exercise improves properties of bone and its collagen network in growing and maturing mice'. Calcif Tissue Int, 85 (3):247-256. Available Online [Details]
Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Turunen A, Silvast TS, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ; (2009) 'Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix'. Exp Gerontol, 44 (11):708-717. Available Online [Details]
Hyttinen MM, Holopainen J, van Weeren PR, Firth EC, Helminen HJ, Brama PA; (2009) 'Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth'. J Anat, 215 (5):584-591. Available Online [Details]
Brama PA, Holopainen J, van Weeren PR, Firth EC, Helminen HJ, Hyttinen MM ; (2009) 'Influence of exercise and joint topography on depth-related spatial distribution of proteoglycan and collagen content in immature equine articular cartilage'. Equine Veterinary Journal, 41 (6):557-563. [Details]
Brama PA, Firth EC, van Weeren PR, Tuukkanen J, Holopainen J, Helminen HJ, Hyttinen MM; (2009) 'Influence of intensity and changes of physical activity on bone mineral density of immature equine subchondral bone'. Equine Veterinary Journal, 41 (6):564-571. [Details]
van Weeren PR, Firth EC, Brommer H, Hyttinen MM, Helminen HJ, Rogers CW, DeGroot J, Brama PA; (2008) 'Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse'. Equine Veterinary Journal, 40 (2):128-135. [Details]
Holopainen JT, Brama PA, Halmesmaki E, Harjula T, Tuukkanen J, van Weeren PR, Helminen HJ, Hyttinen MM; (2008) 'Changes in subchondral bone mineral density and collagen matrix organization in growing horses'. Bone, 43 (6):1108-1114. [DOI] [Details]
de Grauw JC, Brama PA, Wiemer P, Brommer H, van de Lest CH, van Weeren PR; (2006) 'Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia'. American Journal of Veterinary Research, 67 (7):1156-1162. Available Online [Details]
Brommer H, Laasanen MS, Brama PA, van Weeren PR, Helminen HJ, Jurvelin JS.; (2006) 'In situ and ex vivo evaluation of an arthroscopic indentation instrument to estimate the health status of articular cartilage in the equinemetacarpophalangeal joint'. Veterinary Surgery, 35 (3):259-266. Available Online [Details]
de Grauw JC, van de Lest CH, van Weeren R, Brommer H, Brama PA.; (2006) 'Arthrogenic lameness of the fetlock: synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain'. Equine Veterinary Journal, 38 (4):305-311. Available Online [Details]
van der Harst M, Bull S, Brama PA, Barneveld AB, van Weeren PR, van de Lest C; (2006) 'Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints'. Journal of Rheumatology, 33 (8):1662-1667. Available Online [Details]
Brommer H, Brama PA, Laasanen MS, Helminen HJ, van Weeren PR, Jurvelin JS.; (2005) 'Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis'. Equine Veterinary Journal, 37 (2):148-154. Available Online [Details]
Brommer H, Laasanen MS, Brama PA, van Weeren PR, Barneveld A, Helminen HJ, Jurvelin JS; (2005) 'Influence of age, site, and degenerative state on the speed of sound in equine articular cartilage'. AMERICAN JOURNAL OF VETERINARY RESEARCH, 66 (7):1175-1180. Available Online [Details]
van der Harst MR, DeGroot J, Kiers GH, Brama PA, van de Lest CH, van Weeren PR.; (2005) 'Biochemical analysis of the articular cartilage and subchondral and trabecular bone of the metacarpophalangeal joint of horses with early osteoarthritis'. AMERICAN JOURNAL OF VETERINARY RESEARCH, 66 (7):1238-1246. Available Online [Details]
Lin YL, Brama PA, Kiers GH, van Weeren PR, DeGroot J.; (2005) 'Extracellular matrix composition of the equine superficial digital flexor tendon: relationship with age and anatomical site'. Journal of Veterinary Medicine Series A, 52 (7):333-338. Available Online [Details]
Lin YL, Brama PA, Kiers GH, DeGroot J, van Weeren PR; (2005) 'Functional adaptation through changes in regional biochemical characteristics during maturation of equine superficial digital flexor tendons'. American journal of veterinary research, 66 (9):1623-1629. Available Online [Details]
van der Harst MR, van de Lest CH, Degroot J, Kiers GH, Brama PA, van Weeren PR.; (2005) 'Study of cartilage and bone layers of the bearing surface of the equinemetacarpophalangeal joint relative to different timescales of maturation'. Equine Veterinary Journal, 37 (3):200-206. Available Online [Details]
Brommer H, Laasanen MS, Brama PA, van Weeren PR, Helminen HJ, Jurvelin JS.; (2005) 'Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness'. Equine Veterinary Journal, 37 (5):462-467. Available Online [Details]
Grauw J, Lest C, Wiemer P, Van Weeren PR, Brama PAJ ; (2005) 'Inflammatory and degradative synovial fluid marker levels in clinical cases of equine osteochondrosis'. Journal of the American Veterinary Medical Association, . [Details]
van der Harst MR, Bull S, Brama PAJ, van Weeren PR. van de Lest CH ; (2005) 'Nitrite and nitrotyrosine concentrations in articular cartilage and subchondral bone as measures for metabolic level and oxidative stress in normal, juvenile and osteoarthritic equine metacarpophalangeal joints'. Journal of Rheumatology, . [Details]
Jurvelin JS, Brommer H, Laasanen MS, Brama PA, van Weeren PR, Helminen HJ, ; (2005) 'Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness'. Equine Veterinary Journal, 37 (5):462-467. [Details]
DeGroot J, Lin YL, Brama PA, Kiers GH, van Weeren PR, ; (2005) 'Extracellular matrix composition of the equine superficial digital flexor tendon: relationship with age and anatomical site'. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 52 (7):333-338. [DOI] [Details]
Barneveld A, van den Boom R, van de Lest CH, Bull S, Brama RA, van Weeren PR, ; (2005) 'Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints'. Veterinary Journal, 37 (3):250-256. [Details]
van Weeren PR, van der Harst MR, van de Lest CH, Degroot J, Kiers GH, Brama PA, ; (2005) 'Study of cartilage and bone layers of the bearing surface of the equine metacarpophalangeal joint relative to different timescales of maturation'. Veterinary Journal, 37 (3):200-206. [Details]
Jurvelin JS, Brommer H, Brama PA, Laasanen MS, Helminen HJ, van Weeren PR, ; (2005) 'Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis'. Veterinary Journal, 37 (2):148-154. [Details]
DeGroot J, van den Boom R, van der Harst MR, Brommer H, Brama PA, Barneveld A, van Weeren PR, ; (2005) 'Relationship between synovial fluid levels of glycosaminoglycans, hydroxyproline and general MMP activity and the presence and severity of articular cartilage change on the proximal articular surface of P1'. Equine Veterinary Journal, 37 (1):19-25. Available Online [Details]
van Weeren PR, van de Lest CH, Brama PA, van El B, DeGroot J, ; (2004) 'Extracellular matrix changes in early osteochondrotic defects in foals: a key role for collagen?'. Biochimica et biophysica acta, 1690 (1):54-62. [DOI] [Details]
Brommer H, Rijkenhuizen AB, Brama PA, Barneveld A, van Weeren PR; (2004) 'Accuracy of diagnostic arthroscopy for the assessment of cartilage damage in the equine metacarpophalangeal joint'. Equine Veterinary Journal, 36 (4):331-335. [Details]
van der Harst MR, Brama PA, van de Lest CH, Kiers GH, DeGroot J, van Weeren PR; (2004) 'An integral biochemical analysis of the main constituents of articular cartilage, subchondral and trabecular bone'. Osteoarthritis and Cartilage, 12 (9):753-761. [Details]
Brommer H, Brama PA, Barneveld A, van Weeren PR; (2004) 'Differences in the topographical distribution of articular cartilage degeneration between equine metacarpo- and metatarsophalangeal joints'. Equine Veterinary Journal, 36 (6):506-510. [Details]
van de Lest CH, Brama PA, van El B, DeGroot J, van Weeren PR; (2004) 'Extracellular matrix changes in early osteochondrotic defects in foals: a key role for collagen?'. Biochimica et Biophysica Acta, 1690 (1):54-62. [Details]
Brama PA, van den Boom R, DeGroott J, Kiers GH, van Weeren PR; (2004) 'Collagenase-1 (MMP-1) activity in equine synovial fluid: influence of age, joint pathology, exercise and repeated arthrocentesis'. Equine Veterinary Journal, 36 (1):34-40. [Details]
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW; (2004) 'Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals'. American Journal of Veterinary Research, 65 (2):143-150. [Details]
van den Boom R, Brama PA, Kiers GH, DeGroot J, Barneveld A, van Weeren PR; (2004) 'The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and tumour necrosis factor alpha activities in normal equine joints'. Equine Veterinary Journal, 36 (2):155-159. [Details]
van den Boom R, Brama PA, Kiers GH, de Groot J, van Weeren PR; (2004) 'Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses'. American Journal of Veterinary Research, 65 (3):296-302. [Details]
Van Weeren PR, Brama PAJ, DeGroot J, Barneveld A, Rogers CW, Firth EC ; (2004) 'Conditioning of articular cartilage through early exercise: the effect on post-translational modifications of collagen'. AAEP, 50 :234-242. [Details]
Brama PAJ, Barneveld A, van Weeren PR ; (2004) 'Functional adaptation of equine articular cartilage'. AAEP, 50 :145-156. [Details]
Van Weeren PR, Brama PAJ ; (2004) 'Entwicklungsbedingte orthopädische Erkrankungen: Ätiologie und mögliche Beinflussing durch Ernährung und Bewegung'. Berliner Munchener Tierarztlicher Wochenschrift, 85 :184-187. [Details]
van Weeren PR, Brommer H, Rijkenhuizen AB, Brama PA, Barneveld A, ; (2004) 'Accuracy of diagnostic arthroscopy for the assessment of cartilage damage in the equine metacarpophalangeal joint'. Veterinary Journal, 36 (4):331-335. [Details]
van Weeren PR, van den Boom R, Brama PA, Kiers GH, de Groot J, ; (2004) 'Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses'. Veterinary Research, 65 (3):296-302. [Details]
McIlwraith CW, Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, ; (2004) 'Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals'. Veterinary Research, 65 (2):143-150. [Details]
Migliaccio S, Longo M, Brama M, Marino M, Bernardini S, Korach KS, Wetsel WC, Scandurra R, Faraggiana T, Spera G, Baron R, Teti A, ; (2004) 'Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation'. Bone, 34 (1):100-111. [Details]
Brommer H, van Weeren PR, Brama PA, Barneveld A.; (2003) 'Quantification and age-related distribution of articular cartilage degeneration in the equine fetlock joint'. Equine Veterinary Journal, 35 (7):697-701. [Details]
van de Lest CH, Brama PA, van Weeren PR. ; (2003) 'The influence of exercise on bone morphogenic enzyme activity of immature equine subchondral bone'. Biorheology, 40 (1-3):377-382. [Details]
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW. ; (2003) 'Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses'. Osteoarthritis and Cartilage, 11 (10):760-769. [Details]
van Weeren PR, Brama PAJ ; (2003) 'Equine joint disease in the light of new developments in articular cartilage research'. Pferdeheilkunde, 19 (4):336-344. [Details]
Brommer H, van Weeren PR, Brama PA.; (2003) 'New approach for quantitative assessment of articular cartilage degeneration in horses with osteoarthritis'. American journal of veterinary research, 64 (1):83-87. [Details]
Migliaccio S, Taranta A, Brama M, Teti A, De luca V, Scandurra R, Spera G, Agnusdei D, Termine JD, ; (2002) 'The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro'. Bone, 30 (2):368-376. [Details]
Brama PA, TeKoppele JM, Bank RA, Barneveld A, van Weeren PR. ; (2002) 'Development of biochemical heterogeneity of articular cartilage: influences of age and exercise'. Equine Veterinary Journal, 34 (3):265-269. [Details]
Brama PA, TeKoppele JM, Bank RA, Barneveld A, van Weeren PR. ; (2002) 'Biochemical development of subchondral bone from birth until age eleven months and the influence of physical activity'. Equine Veterinary Journal, 34 (2):143-149. [Details]
van de Lest CH, Brama PA, Van Weeren PR. ; (2002) 'The influence of exercise on the composition of developing equine joints'. Biorheology, 39 (1-2):183-191. [Details]
Brama PA, Bank RA, Tekoppele JM, Van Weeren PR. ; (2001) 'Training affects the collagen framework of subchondral bone in foals'. Veterinary Journal, 162 (1):24-32. [Details]
van Weeren PR, Brama PAJ ; (2001) 'Physiology and pathology of the equine joint'. Pferdeheilkunde, 17 (4):307-318. [Details]
Brama PA, Barneveld A, Karssenberg D, Van Kampen GP, van Weeren PR. ; (2001) 'The application of an indenter system to measure structural properties of articular cartilage in the horse. Suitability of the instrument and correlation with biochemical data'. Journal of Veterinary Medicine-Series A, 48 (4):213-221. [Details]
Brama PA, Karssenberg D, Barneveld A, van Weeren PR. ; (2001) 'Contact areas and pressure distribution on the proximal articular surface of the proximal phalanx under sagittal plane loading'. Equine Veterinary Journal, 33 (1):26-32. [Details]
Brama PA, Tekoppele JM, Bank RA, Barneveld A, Firth EC, van Weeren PR. ; (2000) 'The influence of strenuous exercise on collagen characteristics of articular cartilage in Thoroughbreds age 2 years'. Equine Veterinary Journal, 32 (6):217-221. [Details]
Brama PA, TeKoppele JM, Beekman B, van El B, Barneveld A, van Weeren PR. ; (2000) 'Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid'. Annals of Rheumatic Diseases, 59 (2):155-157. [Details]
van Weeren PR, Brama PAJ, Barneveld A.; (2000) 'Exercise at young age may influence the final quality of the equine musculoskeletal system'. Aaep, 46 :29-35. [Details]
Brama PA, Tekoppele JM, Bank RA, Barneveld A, van Weeren PR. ; (2000) 'Functional adaptation of equine articular cartilage: the formation of regional biochemical characteristics up to age one year'. Equine Veterinary Journal, 32 (3):217-221. [Details]
Brama PA, Tekoppele JM, Bank RA, Karssenberg D, Barneveld A, van Weeren PR.; (2000) 'Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint'. Equine Veterinary Journal, 32 (1):19-26. [Details]
Brama PA, Tekoppele JM, Bank RA, van Weeren PR, Barneveld A. ; (1999) 'Influence of different exercise levels and age on the biochemical characteristics of immature equine articular cartilage'. Equine Veterinary Journal Supplement, 31 (suppl):55-61. [Details]
Brama PA, TeKoppele JM, Bank RA, van Weeren PR, Barneveld A. ; (1999) 'Influence of site and age on biochemical characteristics of the collagen network of equine articular cartilage'. American journal of veterinary research, 60 (3):341-345. [Details]
Brama PA, TeKoppele JM, Beekman B, van Weeren PR, Barneveld A. ; (1998) 'Matrix metalloproteinase activity in equine synovial fluid: influence of age, osteoarthritis, and osteochondrosis'. Annals of the Rheumatic Diseases, 57 (11):697-699. [Details]
Brama PA, Rijkenhuizen AB, van Swieten HA, Warmerdam EP. ; (1996) 'Thrombosis of the aorta and the caudal arteries in the horse; additional diagnostics and a new surgical treatment'. The Veterinary Quarterly, 18 (suppl 2):85-89. [Details]
 

Conference Publications

Egan, S; Brama, P; McGrath D (2016) Leveraging Advances in Human Gait Analysis for Application in the Field of Equine Science: A Scoping Review 8th International Conference on Canine and Equine Locomotion [Details]
Brama PAJ; (2011) The influence of exercise on healthy and diseased cartilage British Equine Veterinary Association 2011 Liverpool [Details]
David, F., van Schie, H,. Cadby, J., Bosch, G., Brama, P., van Weeren, R.; (2011) Effect of cast immobilisation on equine SDFT lesion propagation . In: Clegg, P eds. 2011 Annual scientific meeting of the European College of Veterinary Surgeons Ghent, Belgium, , 07-JUL-11 - 09-JUL-11 , pp.70-71 [Details]
Hanna Isaksson, Arto Koistinen, Esa Halmesmäki, Jarkko Ivarinen,Jari P Arokoski, Pieter A Brama, Jukka S Jurvelin, Heikki J Helminen; (2010) Improved bone properties of young hamsters after short-term exercise were not retained in cortical bone during aging but were generally better maintained in trabecular bone Orthopedic Research Society: 56th Annual Meeting [Details]
Viren T, Saarakkala S, Pulkinen H, Tiitu V, Kiviranta I, Lammi M, Brunott A, Weeren van R, Brama PA, Jurvelin JS, Linjama A, Toyras J; (2010) Quantitative evaluation of spontaneously repaired equine cartilage with minimally invasive ultrasound technique Orthopedic Research Society: 56th Annual Meeting [Details]
Kobrina YE, Isakson H, Sinisaari M, Brama P, van Weeren PR, Helminen H, Jurvelin JS, Saarakkala S; (2010) Infrared spectroscopy can detect qualitative and quantitative differences in subchondral bone during maturation Orthopedic Research Society: 56th Annual Meeting [Details]
Sinisaari MJ, Rieppo L, Iivarinen J, Brama PA, Jurvelin JS, Saarakkala S, Korhonen RK, Helminen HJ; (2010) Depth dependent collagen content, orientation and tensile properties of equine cartilage during growth and maturation Orthopedic Research Society: 56th Annual Meeting [Details]
Brama PA; (2009) The fetlock joint: Implementing fundamental research into clinical practice Britisch Equine Veterinary Association: 48th Annual Conference , pp.133-134 [Details]
Brama PA; (2009) Osteochondrosis - a dynamic disease Annual UVH Conference , pp.91-93 [Details]
Brama PA; (2009) Exercising the young horse: a scientific perspective Annual UVH Conference , pp.93-96 [Details]
Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppanen K, Narhi T, Arokoski J, Lammi MJ, Brama PA, Jurvelin JS, Helminen HJ; (2008) Maturation of collagen network in rabbit articular cartilage: effect on tissue mechanics Orthopaedic Reseacrh Society: 55th Annual Meeting [Details]
Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppanen K, Narhi T, Arokoski J, Lammi MJ, Brama PA, Helminen HJ, Jurvelin JS; (2008) Changes in functional properties of collagen and proteoglycan matrix during rabbit maturation: A study utilizing mechanical indentation and finite element analysis Orthopedic Research Society: 55th Annual Meeting [Details]
Brommer H, Brama PA, van Weeren PR; (2008) Early diagnosis of cartilage damage in the future: Wishful thinking or a reality that is within reach European College of Veterinary Surgeons [Details]
Virpi T, Silvast T, Kiviranta O, Pulkinen H, Lammi M, Brunott A, Brama PA, Kiviranta I; (2008) Bone reactions in equine forefeet fetlock joints associated with chondral defects studied with microCT Orthopedic Research Society: 55th Annual Meeting [Details]
                                         

Abstract

Levingstone, TJ,Brama, P,Brady, RT,Thompson, E,O'Brien, FJ,Gleeson, JP (2012) In vivo assessment of the regenerative potential of a novel multi-layer scaffold for osteochondral defect repair. Abstract [Details]
                                                                                           

Research

Research Interests

Research Projects

Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : Erasmus University
Title : Generation of new bone using potent allogeneic paediatric mesenchymal stem cells
Start Date / End Date : 01-SEP-16 / 31-AUG-20
Sponsor : Health Research Board (HRB)
Title : Translation of novel strategies for joint repair from bench to bedside
Start Date / End Date : 01-JUL-12 / 31-JUL-17
Sponsor : University College Dublin Foundation Ltd.
Title : Research and Innovations in Veterinary Surgery
Start Date / End Date : 01-NOV-12 / 30-NOV-17
Sponsor : University College Dublin (UCD)
Title : Wnt3a during expansion enhances chondrogenic capacity of adult human mesenchymal stem cells
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : University College Dublin (UCD)
Title : The influence of exercise on the musculoskeletal system
Start Date / End Date : 01-FEB-15 / 28-FEB-20
Sponsor : Science Foundation Ireland (SFI)
Title : Unravelling the interzone: a biomimicry solution for difficulties in cartilage tissue engineering?
Start Date / End Date : 01-OCT-11 / 31-MAR-16
Sponsor : University College Dublin Foundation Ltd.
Title : Donation: Enhancing Health and Improving Performance
Start Date / End Date : 01-MAY-10 / 28-FEB-15
Sponsor : University College Dublin (UCD)
Title : Enhancing Health and Improving Performance. Physical exercise during development and growth.
Start Date / End Date : 01-JAN-08 / 31-DEC-18
Sponsor : Science Foundation Ireland (SFI)
Title : Determining genetic sensitivity for equine osteochondrosis
Start Date / End Date : 01-JUL-07 / 30-JUN-10

Recent Postgraduates

Mairead Cleary (completed 2016)
Caoimhe Kiernan (completed 2017)

Current Postgraduate Students

Virginia Palomares Cabeza, Doctor of Philosophy (PhD)   -   Thesis Supervisor