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School of Biomolecular & Biomedical Science - Research Publications 2005/06
Below is the list of research publications for the School of Biomolecular & Biomedical Science in the academic year 2005/06
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Collery, R.F., Cederlund, M.L., Smyth, V.A. and Kennedy, B.N. (2006) Applying Transgenic Zebrafish Technology To Study The Retina in Advances in Experimental Medicine and Biology, Hollyfield J.G., Anderson, R.E., and La Vail M.M ed(s)., Springer : New York.
Ward, P.G., Goff, M., Donner, M., Kaminsky, W. and O' Connor, K.E. (2006) A two step chemo- biotechnological conversion of polystyrene to a biodegradable thermoplastic in Environmental Science and Technology, 40, 2433-2437.
Newsholme, P., Brennan, L., Bender, K. (2006) Amino acid metabolism, beta cell function and diabetes in Diabetes, in press,
Nielsen, J.E. (2006) Analysing the pH-dependent properties of proteins using pKa calculations in J Mol Graph Model
Zhang, X., Bajaj, C.L., Kwon, B., Dolinsky, T.J., Nielsen, J.E., Baker, N.A. (2006) Application of new multi-resolution methods for the comparison of biomolecular electrostatic properties in the absence of global structural similarity in Multiscale Modeling and Simulation
Blacque, O.E. & Leroux, M.R. (2006) Bardet-Biedl Syndrome: An emerging pathomechanism of intracellular transport in Cellular and Molecular Life Science, 63, 2145-2161.
De Souza, I.E.J., Brady, A.T., McCabe, O.M., Moran, M.P., Duffy, A. M., Mulvany, S.K. and O’Connor, W.T. (2006) Basal and NMDA-stimulated medial prefrontal glutamate release in two rat models of schizophrenia; effect of chronic clozapine in Irish Journal of Medical Science, 175, (1) 9-9.
O’Connor, W.T., De Souza, I.E.J., Brady, A.T., Moran, M., Duffy, A.M., Mulvany S.K. and McCabe, O.M. (2006) Basal and pergolide induced changes in excitatory and inhibitory transmission in the medial prefrontal cortex in two animal models of schizophrenia in Schizophrenia Research, 81, (1) 206-206.
Quinn, S.T., Guiry, P.J., Schwab, T., Keenan, A.K., McBean, G.J. (2006) Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro in Auton Autacoid Pharmacol, 26, (4) 335-344.
McGrath, L.B., Onnis, V., Campiani, G., Zisterer, D.M., Williams, D.C., and Mc Gee, M.M. (2006) Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells: requirement for chymotrypsin-like serine protease activity and a Mn2+-dependent acidic endonuclease in Apoptosis, 11, (9) 1473-1489.
Murphy, K.J., Foley, A.G., O’Connell, A.W. and Regan, C.M. (2006) Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing in Neuropsychopharmacol, 31, 90-100.
Howlin, J., McBryan, J., Napoletano, S., Lambe, T., McArdle, E., Shioda T. and Martin, F. (2006) CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis in Oncogene 1532-1542.
Cury-Boaventura, M.F., Gorjao R., Martins de Lima, T., Newsholme, P. and Curi, R. (2006) Comparitive toxicity of oleic and linoleic acid on human lymphocytes in Life Sciences, 78, (13) 1448-1456.
Crean, J.K., Furlong, F., Mitchell, D., McArdle E., Godson, C. and Martin, F. (2006) Connective Tissue Growth Factor [CTGF]/CCN2 stimulates actin disassembly through Akt/protein kinase B (PKB) mediated phosphorylation and cytoplasmic translocation of p27Kip-1 in FASEB J,, 20, 1712-1714.
Patterson, S., Flatt, P.R., Brennan, L., Newsholme, P., and McClenaghan, N.H. (2006) Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion in Journal of Endocrinology, 189, (2) 301-310.
MacCallum, D.M, Findon, H., Kenny, C.C., Butler, G., Haynes, K. and Odds, F.C. (2006) Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts in Infection and Immunity, 74, (9) 5244-5248.
Duffy, Á.M., Glennon, J.C., van Scharrenburg, G. and O’Connor, W.T. (2006) Differential effects of the full dopaine D2 receptor agonist pramiprexole on GABA and glutamate release in the globus pallidus ipsilateral and contralateral to a 6-OHDA lesion in Irish Journal of Medical Science, 175, (1) 22-22.
O’Connor, W.T., Duffy, Á.M., Glennon, J.C. and van Scharrenburg, G. (2006) Differential effects of the partial dopamine D2 receptor agonist terguride on GABA and glutamate release in the globus pallidus ipsilateral and contralateral to a 6-OHDA lesion in Schizophrenia Research, 81, (1) 205-205.
McCabe, O.M., De Souza, I.E.J., Brady, A.T., Moran, M.P., Duffy, A. M., Mulvany S.K. and O’Connor, W.T. (2006) Dopamine and glutamate receptor regulation of the glutamate:GABA ratio in the medial prefrontal cortex. Studies in two animal models of schizophrenia in Irish Journal of Medical Science, 175, (1) 6-6.
Brady, A.T., De Souza, I.E.J., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany, S.K. and O’Connor, W.T. (2006) Effect of chronic clozapine on basal and NMDA-stimulated medial prefrontal GABA release in two rat models of schizophrenia in Irish Journal of Medical Science, 175, (1) 21-21.
De Souza, I.E.J., Brady, A.T., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany, S.K. and O’Connor, W.T. (2006) Effect of environment and clozapine on basal and pergolide stimulated medial prefrontal GABA release in two rat models of schizophrenia in Schizophrenia Research, 81, (1) 203-203.
Fitzpatrick, F., Humphreys, H. and O'Gara, J. P. (2006) Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus in Journal of Hospital Infection, 62, (1) 120-122.
Hanel, M. L. and Hensey, C. (2006) Eye and neural defects associated with loss of GDF6 in BMC Developmental Biology, 6, 1-13.
Krieger, E., Nielsen, J.E., Spronk, C.A.E.M., Vriend, G. (2006) Fast Empirical pKa Prediction by Ewald Summation in J Mol Graph Model
Cagney, G., Alvaro, D., Reid, R.J., Thorpe, P.H., Rothstein, R., Krogan, N.J. (2006) Functional genomics of the yeast DNA-damage response in Genome Biol, 7, (9) 233
Wang, X.T., Lam V.M.S. and Engel, P.C. (2006) Functional properties of two mutants of human glucose 6-phosphate dehydrogenase, R393G and R393H, corresponding to the clinical variants G6PD Wisconsin and Nashville in Biochimica et Biophysica Acta (Molecular Basis of Disease), 1762, 767-774.
Cadogan, J.I., Hewage, C.M., McNab, H., Macpherson, A.D., Nicolson, I.S., Reed, D., Sadler, I.H. (2006) Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals in Org Biomol Chem, 4, (12) 2446-2451.
Corless, M., Kiely A., McClenaghan, N.H., Flatt, P.R. and Newsholme P. (2006) Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene and protein expression in a clonal pancreatic beta cell line in Journal of Endocrinology, 190, (3) 719-727.
Sweeney, N., Gallagher, W. M., Müller-Bunz, H., Pampillón, C., Strohfeldt, K., and Tacke, M. (2006) Heteroaryl substituted titanocenes as potential anti-cancer drugs in Journal of Inorganic Biochemistry,, 100, 1479-1486.
Kelley-Hickie, L.P. and Kinsella, B.T. (2006) Homologous desensitization of signalling by the beta (b) isoform of the human thromboxane A2 receptor. Agonist-mediated desensitization of TPb in Biochim Biophys Acta, 1761, (9) 1114-1131.
De Souza, I.E.J., Brady, A.T., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany S.K. and O’Connor, W.T. (2006) Hypoglutamatergia in the rat medial prefrontal cortex in two models of schizophrenia: basal and effect of pergolide in Schizophrenia Research, 81, (1) 203-203.
Mulligan, J.M., Greene, L.M., Mc Gee M.M, Onnis, V., Campiani, G.,Lawler, M., Williams, D.C., Zisterer D.M. (2006) Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines in Molecular Pharmacology, 70, (1) 60-70.
Brennan, L., Alves, P.M., Hewage, C., Malthouse, J.P. and McBean, G.J. (2006) Impact of gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes in Neurochem. Int, 48, (8) 739-745.
Peretz, D., Supattapone, S., Giles, K., Vergara, J., Freyman, Y., Lessard, P., Safar, J.G., Glidden, D.V., McCulloch, C., Nguyen, H.-O., Scott, M., Dearmond, S.J. and Prusiner, S.B. (2006) Inactivation of prions by acidic sodium dodecyl sulfate in Journal of Virology, 80, (1) 322-331.
Butland, G., Krogan, N.J., Xu, J., Yang, W.H., Aoki, H., Li, J.S., Krogan, N., Menendez, J., Cagney, G., Kiani, G.C., Jessulat, M.G., Datta, N., Ivanov, I., Abouhaidar, M.G., Emili, A., Greenblatt, J., Ganoza, M.C., Golshani, A. (2006) Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs in J Cell Biochem, Epub ahead of print,
Pan, X., Ou, G., Civelekoglu-Scholey, G., Blacque, O.E., Endres, N.F., Tao, L., Mogilner, A., Leroux, M.R., Vale, R.D., Scholey, J.M. (2006) Mechanism of transport of IFT-particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors in Journal of Cell Biology, 174, 1035-1045.
Mooney, A, P.G. Ward, P.G, and O'Connor, K.E. (2006) Microbial degradation of styrene: biochemistry, molecular genetics, and perspectives for biotechnological applications in Appl Microbiol Biotechnol, 72, 1-10.
Gallagher, W. M., Lynch, I., Allen, L. T., Miller, I., Penney, S. C., O’Connor, D. P., Pennington, S., Keenan, A. K., and Dawson, K. A. (2006) Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies in Biomaterials,, 27, (35) 5871-5882.
Lasker, B.A., Butler, G. & Lott, T.J. (2006) Molecular genotyping of Candida parapsilosis group I clinical isolates by analysis of polymorphic microsatellite markers in Journal of Clinical Microbiology, 44, (3) 750-759.
Haber, E.P., Procópio, J., Carvalho, C.R.O., Carpinelli, A.R., Newsholme, P. and Curi, R. (2006) New insights into fatty acid modulation of pancreatic beta cell function in Int Rev Cytol, 248, 1-41.
O’Connor, W.T. (2006) Newer antipsychotic drugs: nexuses between neuroscience and psychiatry in The International Journal of Neuropsychopharmacology, 9, (1) 24-24.
Rawe, S.L., Zaric, V, O'Boyle, K.M. & Murphy, P.M. (2006) N-glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - a significant increase in potency using per-O-acetylated sugar analgues in Bioorg Med Chem Letts, 16, 1316-1319.
Rawe, S.L., Doyle, D., Zaric, V., Rozas, I., McMahon, K., Tosin, M., Bunz, H.M., Murphy, E., O'Boyle, K.M. & Murphy, P.V. (2006) N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types in Carb Res, 341, (10) 1370-1390.
Brennan, L., Hewage, C., Malthouse, J.P.G., McClenaghan, N.H., Flatt, P.R., Newsholme, P. (2006) NMR analysis reveals prolonged sulphonylurea exposure impacts on the regulation of pancreatic beta-cell metabolism in FEBS J, in press,
Alana, I., Parker, J.C., Gault, V.A., Flatt, P.R., O'Harte, F.P., Malthouse, J.P., Hewage, C.M. (2006) NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water in J. Biol. Chem., 281, (24) 16370-16376.
McGillicuddy, F.C., Lynch, I., Rochev, Y.A., Burke, M., Dawson, K.A., Gallagher, W.M., Keenan, A.K. (2006) Novel “plum pudding” gels as potential drug-eluting stent coatings: controlled release of fluvastatin in J Biomed Mater Res A, Epub ahead of print,
Lynch, I., Miller, I., Gallagher, W. M., and Dawson, K. A. (2006) Novel method to prepare morphologically rich polymeric surfaces for biomedical applications via phase separation and arrest of microgel particles in Journal of Physical Chemistry B Condens. Matter Mater. Surf. Interfaces Biophys.,, 110, (30) 14581-14589.
Slattery, C., McMorrow, T., Ryan, M.P. (2006) Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis in FEBS Letters, 580, (17) 4021-4030.
Kavanagh, C.A., Gorelova, T.A., Selezneva, II., Rochev, Y.A., Dawson, K.A., Gallagher, W.M., Gorelov, A.V., Keenan, A.K. (2006) Poly(N-isopropylacrylamide) copolymer films as vehicles for the sustained delivery of proteins to vascular endothelial cells in J Biomed Mater Res A, 72, (1) 25-35.
Tobin, K. and O’ Connor, K.E. (2006) Polyhydroxyalkanoate accumulating diversity of Pseudomonas species utilising aromatic hydrocarbons in FEMS microbiology Letters, 253, 111-118.
Easty, D., Gallagher, W., and Bennett, D. C. (2006) Protein tyrosine phosphatases, new targets for cancer therapy in Current Cancer Drug Targets,, 6, 433-445.
Currid, C., O’Connor, D. P., Gebus, C., Harris, N., Chang, B. D., Pennington, S. R., Dawson, K., Roninson, I. B., and Gallagher, W. M. (2006) Proteomic analysis of factors released from p21-overexpressing tumour cells in Proteomics,, 6, 3739-3753.
Murphy, C.D. (2006) Recent developments in enzymatic chlorination in Natural Product Reports, 23, (2) 147-152.
Campbell, E., Slattery, C., Tuite, N., Nolan, S., Leonard, M., Ryan, M.P. and McMorrow, T. (2006) RNA Interference: a novel alternative approach in nephrotoxicity studies in ALTEX, 23, 406-409.
Messias, A.C., Aguiar, A.P., Brennan, L., Salgueiro, C.A., Saraiva, L.M. Xavier, A.V., Turner, D.L. (2006) Solution structure of tetrahaem ferricytochrome c3 from Desulfovibrio vulgaris (Hildenborough) and its K45Q mutant: the molecular basis of cooperativity in Biochim Biophys Acta –Bioenergetics, 1757, 143-153.
Muller, H.K., Wiborg, O. and Haase, J. (2006) Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2 in Journal of Biological Chemistry, 281, (39) 28901-28909.
Allen, L.T., Tosetto, M., Miller, I., O’Connor, D., Penney, S.C., Lynch, I., Keenan, A.K., Pennington, S.R., Dawson, K.A., and Gallagher, W.M. (2006) Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction in Biomaterials,, 27, (16) 3096-3108.
Hanson, J., Reynaud, D., Qiao, N., Winum, J-Y., Renard, J.F., Kelley, L.P., Kinsella, B.T., Pirotte, B., Pace-Asciak, C.R., and Dogne, J.M. (2006) Synthesis and pharmacological evaluation of original nitrobenzenic thromboxane modulators as anti-platelet agents acting on both the alpha and beta isiforms of the human thromboxane receptor in Journal of Medicinal Chemistry, 49, (12) 3701-3709.
McGillicuddy, F.C., O’Toole, D., Hickey, J.A., Gallagher, W.M., Dawson, K.A., and Keenan, A.K. (2006) TGF-b1 induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells in Vascular Pharmacology,, 44, 469-475.
Conway, C.M., O’Shea, D., O’Brien, S., Lawler, D.K., Dodrill, G.D., O’Grady, A., Barrett, A., Gulmann, C., O’Driscoll, L., Gallagher, W.M., Kay, E.W., and O’Shea, D.G. (2006) The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line in BMC Bioinformatics,
Walsh, M.C., Brennan, L., Malthouse, J.P.G., Roche, H.M., Gibney, M.J. (2006) The effect of acute dietary standardisation on the urinary, plasma and salivary metabolomic profiles of healthy human subjects in Am. J. Clin. Nutr, 84, 531-539.
Fitzpatrick, F., Humphreys, H. and O'Gara, J.P. (2006) The genetics of staphylococcal biofilm formation–will a greater understanding of pathogenesis lead to better management of device-related infection? in Clinical Microbiology and Infection, 11, (12) 967-973.
Faulkner, E., Barrett, M., Okor, S., Kieran, P., Casey, E., Paradisi, F., Engel P.C. and Glennon, B. (2006) The use of fed batch cultivation for achieving high cell densities for the pilot scale production of a recombinant protein (Phenylalanine dehydrogenase) in Escherichia coli in Biotechnology Progress, 22, 882-897.
Paradisi, F., Collins, S., Maguire, A.R. and Engel, P.C. (2006) The use of phenylalanine dehydrogenase mutants as efficient catalysts for the synthesis of non-natural amino acids: scale-up process in in press
Duggan, S., Gallagher, W.M., Abdel-latif, M., Fox, E.J.P., Reynolds, J.R., and Kelleher, D. (2006) The use of transcriptomic approaches in the analysis of oesophageal cancer, a low pH gene induction study in Carcinogenesis,, 27, (2) 319-327.
Brooks S.J., Doyle E.M., and O’ Connor, K.E. (2006) Tyrosol to hydroxytyrosol biotransformation by immobilised cell extracts of Pseudomonas putida F6 in Enzyme and Microbial Technology, 39, 191-196.
Coyle, A.T., O’Keeffe, M.B. and Kinsella, B.T. (2005) 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by Promoter 3 of the human Thromboxane A2 receptor gene through Peroxisome Proliferator-Activated Receptor g in human erythroleukemia cells in FEBS Journal, 272, 4754-4773.
Gallagher, W.M., Allen, L.T., O’Shea, C., Kenna, T., Hall, M., Gorman, A., Killoran, J., and O’Shea, D.F. (2005) A potent non-porphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia in British Journal of Cancer,, 92, (9) 1702-1710.
Ghavidel, A., Cagney, G., Emili, A. (2005) A skeleton of the human protein interactome in Cell, 122, (6) 830-832.
Nolan, L. and O’ Connor, K.E. (2005) A spectrophotometric method for the quantification of an enzyme activity producing 4-substituted phenols: determination of toluene-4-monooxygenase activity in Analytical Biochemistry, 344, 224-231.
Rehmann, F.J.K., Rous, A.J., Mendoza, O., Sweeney, N.J., Strohfeldt, K., Gallagher, W.M., and Tacke, M. (2005) A trimethoxyphenyl substituted ansa-titanocene: a possible anti-cancer drug in Polyhedron,, 24, 1250-1255.
Pickering, M., Cumiskey, D. and O'Connor, J.J. (2005) Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system in Experimental Physiology, 90, (5) 663-670.
Conboy, L., Murphy, K.J. and Regan, C.M. (2005) APP expression in the hippocampal dentate gyrus modulates during memory consolidation in J Neurochem. 9, 5, 1677-88.
Brennan, D., O’Brien, S., Fagan, A., Culhane, A.C., Higgins, D.G., Duffy, M.J., and Gallagher, W.M. (2005) Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response in Expert Opinion in Biological Therapy,, 5, (8) 1069-1083.
Carmody, M., Murphy, B., Byrne, B., Power, P., Rai, D., Rawlings, B., Caffrey, P. (2005) Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups in Journal of Biological Chemistry, 280, (41) 34420-34426.
Coyle, A.T. and Kinsella, B.T. (2005) Characterisation of Promoter 3 of the human thromboxane A2 receptor gene. A functional AP-1 and octamer motif are required for basal promoter activity. in FEBS Journal, 272, 1036-1053.
Foley, A.G., Murphy, K.J. and Regan, C.M. (2005) Complex environment rearing reverses prenatal hypoxia-induced deficits in learning and hippocampal polysialylated NCAM function in J Neurosci Res, 82, 245-54.
Lynch, I., Blute, I.A., Zhmud, B., MacArtain, P., Tosetto, M., Allen, L. T., Byrne, H.J., Farrell, G.F., Keenan, A.K., Gallagher, W.M., and Dawson, K.A. (2005) Correlation of the adhesive properties of cells to N-isopropylacrylamide/N-tert-butylacrylamide copolymer surfaces with changes in the surface structure using contact angle measurements, molecular simulations and raman spectroscopy in Chemistry of Materials,, 17, (15) 3889-3898.
McMorrow, T., Gaffney, M.M., Slattery, C., Campbell, E., Ryan, M.P. . (2005) Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells in Nephrology Dialysis Transplantation, 20, (10) 2215-2225.
Slattery, C., Campbell, E., McMorrow, T., Ryan, M.P. . (2005) Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition in American Journal of Pathology, 167, (2) 395-407.
Duffy, M.J., Kelly, Z.D., Culhane, A.C., O’Brien, S., and Gallagher, W.M. (2005) DNA microarray-based gene expression profiling in cancer: aiding cancer diagnosis, assessing prognosis and predicting response to therapy in Current Pharmacogenomics,, 3, 289-304.
Cainelli, G., Engel, P.C., Galletti, P., Giacomini, D., Gualandi, A. and Paradisi, F. (2005) Engineered phenylalanine dehydrogenase in organic solvents: homogeneous and biphasic enzymatic reactions in Org. Biomol. Chem, 3, 4316-4320.
Gallagher, W. M., Currid, C. A., and Whelan, L. C. (2005) Fibulins and cancer: friend or foe? in Trends in Molecular Medicine,, 11, (7) 336-340.
O’Leary, N.D., Ward, P., Goff, M., O’Connor, K.E. and Dobson, A.D.W. (2005) Genetic characterisation of polyhydroxyalkonate accumulation from styrene in Pseudomonas putida CA-3 in Appl. Environ. Microbiol, 71, 4380-4387.
Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrin-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete, M.M., Vlasblom, J., Wu, S., Orsi, C., Collins, S.R., Chandran, S., Haw, R., Rilstone, J.J., Gandi, K., Thompson, N.J., Musso, G., St Onge, P., Ghanny, S., Lam, M.H., Butland, G., Altaf-Ul, A.M., Kanaya, S., Shilatifard, A., O'Shea, E., Weissman, J.S., Ingles, C.J., Hughes, T.R., Parkinson, J., Gerstein, M., Wodak, S.J., Emili, A., Greenblatt, J.F. (2005) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae in Nature, 440, (7084) 637-643.
Cagney, G., Park, S., Chung, C., Tong, B., O'Dushlaine, C., Shields, D.C., Emili, A. (2005) Human tissue profiling with multidimensional protein identification technology in J Proteome Res, 4, (5) 1757-1767.
Paradisi, F.,
Woolfson, R., Geoghegan K.F. and Engel, P.C. (2005) Identification of the residue responsible for catalysing regeneration of activity in the inactive glutamate dehydrogenase mutant D165N in FEBS Letters, 579, 2830-2832.
Hanson, J., Rolin, S., Reynaud, D., Qiao, N., Kelley, L.P., Reid, H.M., Valentin, F., Tippins, J., Kinsella, B.T., Masereel, B., Pace-Asciak, C., Pirotte, B. and Dogné , J-M. (2005) In vitro and in vivo pharmacological characterization of BM-613, a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist in The Journal of Pharmacology & Experimental Therapeutics, 313, 293-301.
Ward, P.G. and O’ Connor, K.E. (2005) Induction and quantification of phenylacyl-CoA ligase enzyme activities in Pseudomonas putida CA-3 grown on aromatic carboxylic acids in FEMS microbiology Letters, 251, 227-232.
Wall, D.M., Duffy, P.S., DuPont, C., Prescott, J.F.& Meijer, W.G. (2005) Isocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi in Infection and Immunity, 73, (10) 6736-6741.
Rachidi, W., Riondel, J., McMahon H.M., Favier A. (2005) La protéine du prion et le cuivre: un lien mystérieux. Prion protein and copper: a mysterious relationship in Pathologie Biologie, 53, 244-250.
Cunningham, G., McClenaghan, N.H., Flatt, P.R. and Newsholme, P. (2005) L-alanine induces changes in metabolic and signal transduction gene expression in a clonal pancreatic beta cell line and protects from pro-inflammatory cytokine induced apoptosis in Clinical Science, 109, (5) 447-455.
Wang, X.T., Lam, V.M.S. and Engel, P.C. (2005) Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PDUnion and G6PDAndalus in . Human Mutation MIB, http://www3.interscience.wiley.com/cgi-bin/jabout/38515/pdf/838.pdf,
Gibney, M.J., Walsh, M., Brennan, L., Roche, H.M., German, B., Van Ommen, B. (2005) Metabolomics in human nutrition: opportunities and challenges in Am J Clin Nutr, 82, 497-503.
Gallagher, W.M., Bergin, O.E., Rafferty, M., Kelly, Z.D., Nolan, I.M., Fox, E.J.P., Culhane, A.C., McArdle, L., Fraga, M.F., Hughes, L., Currid, C.A., O’ Mahony, F., Byrne, A., Murphy, A.A., Moss, C., McDonnell, S., Stallings, R.L., Plumb, J.A., Esteller, M., Brown, R., Dervan, P.A., and Easty, D.J. (2005) Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies in Carcinogenesis,, 26, (11) 1856-1867.
Newsholme, P., Brennan, L., Rubi, R., Maechler, P. (2005) New insights into amino acid metabolism, beta cell function and diabetes in Clin Sci, 108, 185-194.
Furlong, F., Finlay, D., Martin, F. (2005) PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis in Biochem Biophys Res Commun, 336, 1292-1299.
Roxburgh, S.A., Murphy, M., Pollock, C.A. and Brazil D.P. (2005) Recapitulation of embryological programmes in renal fibrosis-the importance of epithelial cell plasticity and developmental genes in Nephron Physiology, 103, 139-148.
McDonnell, S.O., Hall, M.J., Allen, L.T., Byrne, A., Gallagher, W.M., and O'Shea, D.F. (2005) Supramolecular photonic therapeutic agents in Journal of the American Chemical Society,, 127, (47) 16360-16361.
Tolbert, B., Tajc, S., Webb, H., Snyder, J., Nielsen, J.E., Miller, B., Basavappa, R. (2005) The active site cysteine of ubiquitin conjugating enzymes has a significantly elevated pKa: functional implications in Biochemistry, 44, (50) 16385-16391.
Caffrey, P. (2005) The stereochemistry of ketoreduction in Chemistry & Biology, 12, (1) 1060-1062.
Hayes, D., Wiessner, M., Rauen, T. and McBean, G.J. (2005) Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters overexpressed in HEK cells in Neurochemistry International, 46, 585-594.
Tynan-Connolly, B.M., Nielsen, J.E. pKD: Re-Designing protein pKa values in Nucleic Acids Research, 34, (W) 48-51.
Brennan, D.J., Kronblad, A., Jirstrom, K., Landberg, G., Duffy, M.J., Gallagher, W.M., and O’Brien, S. (2006) Carbonic anhydrase IX is a new independent prognostic marker in pre-menopausal breast cancer patients with 1 to 3 positive lymph nodes in Proceedings of the American Association for Cancer Research, 47 Abs. 3608
Collins, B.C., Whelan, L., Power, K., and Gallagher, W.M. (2006) Early toxicity testing in Technology Ireland, 37, (2) 22-23.
Murphy, K.J. (2006) Pain and Addiction: A relationship for all time? in PainWise: Irish Journal of Pain Medicine, 5 3-7.
Murphy, K.J., Regan, C.M. (2006) Research update: Applied Neurotherapeutics Research Group, A year of discovery in DMMC News, June 3-4.
Hughes, L., Malone, K., O'Brien, S., Gallagher, W. M., and McDonnell, S. (2005) Development, characterisation and gene expression profiling of a novel more invasive variant established from the human breast cancer cell line Hs578T in European Journal of Cancer Supplements, 3 88
Brennan, L. (2005) Metabolic profiling using Nuclear Magnetic Resonance spectroscopy in Irish Scientist, 13 100-100.
Cummins, E., Gallagher, W.M., O’Brien, E., Stanton, A., Cagney, G., and Cahill, D.J. (2005) Metabolic syndrome biomarker discovery by surface enhanced laser desorption/ionisation time-of-flight mass spectrometry in Molecular and Cellular Proteomics, 4
Currid, C., O’Connor, D.P., Gebus, C., Chang, B.-D., Harris, N., Dawson, K., Pennington, S.R., Roninson, I.B., and Gallagher, W.M. (2005) Proteomic analysis of factors released from p21-overexpressing tumour cells in Molecular and Cellular Proteomics, 4
Kavanagh, C.A., Rochev, Y., Gorelov, A., Gallagher, W.M., and Keenan, A.K. (2005) Thermoresponsive p(N-isopropylacrylamide)-based co-polymers as protein delivery systems and substrates for re-endothelialisation in Proceedings of the British Pharmacological Society, 2, (2) 14P
Connole, L., Conboy, L., Regan, C.M. and Murphy, K.J. (2006) A role for neural molecular guidance molecules ROBO and SLIT in memory-associated hippocampal synaptic reorganization. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Lawlor, M.K., Conboy, L.A., Murphy, K.J., Regan, C.M. (2006) Design of disease modifying drugs for dementia. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Gannon, S., Conboy, L. and Regan, C.M. (2006) Development of a screening methodology for the evaluation of drugs withdrawn under the DESI program. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M. (2006) Development of an automated screening system that detects change in stem cell fate induced by endocrine disruptors. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Mulryan, L.J., Murphy, K.J. and Regan, C.M. (2006) Differential alterations of spatial learning ability in male and female rats due to perinatal exposure to exogenous estrogens. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Horst, J.P., Regan, C.M. and Murphy, K.J. (2006) NCAM polysialylation is increased in the prefrontal cortex following spatial learning but not avoidance conditioning. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Mulryan, L.J., Murphy, K.J. and Regan, C.M. (2006) Perinatal exposure to exogenous estrogens differentially alters behaviour in adult male and female Wistar rats. 5th Forum of European Neuroscience, FENS, Vienna (8-12th July 2006)
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2006) Synaptic remodeling underlying long term memory consolidation in the cerebral cortex. Irish J Med Sci, 175, 31. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2006) Synaptic remodeling underlying long term memory consolidation. 5th Forum of European Neuroscience, FENS, Vienna (8-12th July 2006)
Mulvany, S.K., Cassidy, A., Seymour, C.M., Marquis, K.L., Logue, S.F. and Regan, C.M. (2006) The developmental emergence of anomalies in sensorimotor gating and exploratory behaviour in maternally deprived and isolation reared rats. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Mulvany, S.K. and Regan, C.M. (2006) Understanding animal interest in pleasurable activities. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Brady, A.T., DeSouza, I.E.J., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany S.K. and O’Connor, W.T. (2006) Altered dopamine regulation of medial prefrontal glutamate and GABA release in the socially isolated and maternally deprived rat. An in vivo microdialysis study. 11th International Conference on Invivo Methods, Cagliara, Italy (19th – 22nd May, 2006)
Newsholme, P., Brennan, L. and Bender, K. (2006) Amino acid metabolism, beta cell function and diabetes. International Group on Insulin Secretion and Servier Symposium, Cap Ferrat, Nice, France (29th - 31st March 2006)
Butler, S., Wellstead, P., Reilly, R.G. and O’ Connor, W.T. (2006) An integrated environment for the visualisation and analysis of microdialysis data. 11th International Conference on Invivo Methods, Cagliara, Italy (19th – 22nd May, 2006)
Nielsen, J.E. (2006) Analysing protein pKa calculations. Structure based drug discovery,, Whistler, British Columbia, Canada, (April 4-9th 2006)
Brennan, L., Hewage, C., Malthouse, J.P.G, Colhoun, H. (2006) Analysis of metabolic profiles of biofluids from patients with type 1 Diabetes Mellitus. Metabolomics Conference, Boston, USA (24-29 June)
O’Connor, M.M., Halpin, R.M., McMahon, A.M., O’Riordan, E.D., O’Sullivan, M., Brady, D.B. (2006) Antimicrobial Properties of Dairy Powders. 36th Annual Research Conference: Food, Nutrition and Consumer Science, Cork, Ireland (14th September 2006)
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., and Dervan, P.A. (2006) Array CGH-based analysis of ductal breast cancer variants: comparing in situ and invasive carcinomas. European Association for Cancer Research-19, Budapest (1 – 4 July 2006)
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., and Dervan, P.A. (2006) Array CGH-based analysis of genetic alterations in ductal breast cancer subtypes. EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, Dublin, Ireland (12 - 14 July 2006)
Ryan, D., Rafferty, M., McSherry, E., McGoldrick, A., Dervan, P.A., and Gallagher, W.M. (2006) Array-based CGH analysis of a cohort of melanoma cell lines. Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway, Ireland (3 – 4 March 2006)
Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O’Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A. and Gallagher, W.M. (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome. Automated quantitative analysis of immunohistochemistry linked to clinical outcome, Dublin, Ireland
O'Donnell, S.T., Lee, C.Y. and O'Gara, J.P. (2006) Biofilm regulation by the AraC-type transcriptional regulator Rbf in Staphylococcus aureus and Staphylococcus epidermidis. International Symposium on Saphylococci and Staphylococcal Infections, Maastricht, The Netherlands (3rd-6th September 2006)
Gallagher, W.M. (2006) Biomarker discovery via the SELDI platform: case studies in the cancer arena [NOTE: Keynote speaker]. The Biomarker Discovery Event: Leveraging multiplex experimental technologies for drug development, Basel, Switzerland (10 February 2006)
Herron, C. and Martial, M. (2006) Cannabinoids modulate in vivo synaptic transmission in the nucleus Accumbens of rats. Federation of European Neurosceinces, Vienna (July 2006)
Herron, C. and Martial, M. (2006) Cannabinoids modulate synaptic transmission in the rat Nucleus Accumbens in vivo. The International Cannabionoid Research Society, Tihany, Hungary (June 24-29)
Brennan, D.J., Kronblad, A., Jirstrom, K., Landberg, G., Duffy, M.J., Gallagher, W.M., and O’Brien, S. (2006) Carbonic anhydrase IX is a new independent prognostic marker in pre-menopausal breast cancer patients with 1 to 3 positive lymph nodes. 97th Annual Meeting of the American Association for Cancer Research, Washington DC, USA (1 – 5 April 2006)
Brennan, D.J., Kronblad, A., Jirstrom, K., Landberg, G., Duffy, M.J., Gallagher, W.M., and O’Brien, S. (2006) Carbonic anhydrase IX is a new independent prognostic marker in pre-menopausal breast cancer patients with 1 to 3 positive lymph nodes. Sylvester O’Halloran Surgical Scientific Meeting, Ireland (03/03/2006)
Ryan, D., Rafferty, M., McSherry, E., McGoldrick, A., Dervan, P.A., and Gallagher, W.M. (2006) Comparative genomic hybridisation study on a cohort of melanoma cell lines. Centenary Meeting of the Pathological Society of Manchester, University Of Manchester (4 - 7 July 2006)
McGee, S., O’Connor, D., Roninson, I., Duffy, M., and Gallagher, W.M. (2006) Construction of a lentiviral RNAi library for the functional analysis of genes associated with breast cancer metastasis. EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, Dublin, Ireland (6 – 8 June 2006)
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M. (2006) Determination of the changes in stem cell fate induced by endocrine disruptors through the use of an automated image analysis package. RAMI Section of Biomedical Sciences Winter Meeting, University College Dublin (12th January 2006)
Butler, S., Reilly, R.G., Wellstead, P., O’ Connor, W.T. & Verwoerd, M.H.A. (2006) Dynamic visualisation and analysis of neurotransmitter data. International Workshop on Systems Biology, NUI Maynooth (, 17th – 19th July, 2006)
Halpin, R.M., O’Connor, M.M., Boughton, C., O’Riordan, E.D., O’Sullivan, M., Brady, D.B. (2006) Effect of Hydrolysed Whey Products on Adhesion of S.mutans to Hydroxyapatite in vitro. Society for General Microbiology, Irish Branch Meeting, Dublin, Ireiand (31st August-1st September 2006)
Bender, K., Maechler, P., Newsholme, P. (2006) EFFECT OF INCREASED L- ALANINE, L- GLUTAMINE, L- ASPARTATE AND GLUCOSE CONCENTRATIONS ON INS- 1E CELLS OVER- EXPRESSING ARALAR1. European Association for the Study of Diabetes (EASD), Copenhagen, Denmark (13th - 17th September 2006)
O’Neill, E., Pozzi, E., Houston, P., Smyth, D. Robinson, D.A., Humphreys, H. and O’Gara, J.P. (2006) Evidence for ica-dependent and ica-independent biofilm mechanisms in methicillin susceptible and methicillin resistant Staphylococcus aureus clinical isolates. International Symposium on Saphylococci and Staphylococcal Infections, Maastricht, The Netherlands (3rd-6th September 2006)
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., and Dervan, P.A. (2006) Genetic determinants of progression of ductal carcinoma in situ to invasive breast cancer. Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway, Ireland (3 – 4 March 2006)
McMahon, A.M., Halpin, R.M., O’Connor, M.M., O’Riordan, E.D., O’Sullivan, M., Brady, D.B. (2006) Growth inhibition of food-borne pathogens and food spoilage organisms by an antimicrobial agent derived from whey. 36th Annual Research Conference: Food, Nutrition and Consumer Science, Cork, Ireland (14th September 2006)
Chen, X., Yang, J. and Meijer, W.G. (2006) Identification of a sensor kinase and arylsulfatase interacting with the orphan response regulator VirS (Orf8) encoded by the virulence plasmid of Rhodococcus equi. Society for General Microbiology, Autumn meeting, Dublin, Ireland (31 August 2006)
Lanigan, F., McBryan, J., Brennan, D., Duffy, M.J., Martin, F. and Gallagher, W.M. (2006) Identification of common pathways involved in pubertal mammary gland development and breast cancer. EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, Dublin, Ireland (6 – 8 June 2006)
Halpin, R.M., O’Connor, M.M., Boughton, C., O’Riordan, E.D., O’Sullivan, M., Brady, D.B. (2006) Inhibition of Adhesion of Cariogenic Streptococci to Hydroxyapatite by Enzyme-modified Whey Protein Concentrates. 36th Annual Research Conference: Food, Nutrition and Consumer Science, Cork, Ireland (14th September 2006)
Halpin, R. M., O’Connor, M. M., Boughton, C., O’Riordan, E. D., O’Sullivan, M., Brady, D. B. (2006) Inhibition of Adhesion of S.mutans to Hydroxyapatite by Enzyme-modified Whey Products. 158th Meeting of the Society for General Microbiology, Warwick, UK (3rd-6th April)
O’Leary, D.M., Grennan, G.Z., O’Connor, J.J. and Herron, C.E. (2006) Inhibition of DHPG induced LTD in the hippocampal CA1 in vitro. Federation of European Neurosceinces, Vienna (July 2006)
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., and Dervan, P.A. (2006) Investigation of genetic alterations in ductal breast cancer subtypes using array-CGH. Mater 9th International Breast Cancer Meeting, Dublin, Ireland (7 - 8 April 2006)
Miranda-CasoLuengo, R. and Meijer, W.G. (2006) Iron Acquisition by Rhodococcus equi: IupABC System Transports a Catecholate Siderophore. Society for General Microbiology, Autumn meeting, Dublin, Ireland (31 August 2006)
Hegarty, S., Murray, E., McAllister, K., Ryan, D., Rafferty, M., Gallagher, W.M., and Dervan, P.A. (2006) Malignant melanoma: using tissue microarrays to understand a killer. Pathological Society Centenary Meeting, Manchester, UK (July 2006)
Hegarty, S., Murray, E., McAllister, K., Ryan, D., Rafferty, M., Gallagher, W.M., and Dervan, P.A. (2006) Malignant melanoma: using tissue microarrays to understand a killer. Association of Clinical Pathologists International Scientific Meeting, Praque (June 2006)
Herron, C., Grennan, G., Dolan, C., O'Connor, J., O'Leary, D. (2006) Metabotropic glutamate receptor mediated LTD in the CA1 region: A role for the lipoxygenase pathway and endocannabinoids. The International Cannabionoid Research Society, Tihany, Hungary (June 24-29)
Kelly, M.E.M., Da Silva, N., Herron, C.E., Stevens, K., Barnes, S. (2006) Metabotropic receptor mediated Müller cell calcium signaling in the mammalian retina: Possible role of TRP channels. Canadian Physiology Society Meeting, Lake Louise, Alberta, Canada (Feb 1-4 2006)
Faller, W., Rafferty, M., Fraga, M., Esteller, M., and Gallagher, W. (2006) Methylation profiling of genes associated with melanoma progression. 97th Annual Meeting of the American Association for Cancer Research, Washington DC, USA (1 – 5 April 2006)
Faller, W., Rafferty, M., Fraga, M., Esteller, M., and Gallagher, W. (2006) Methylation profiling of genes associated with melanoma progression. Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway, Ireland (3 – 4 March 2006)
Byrne, A.T., Miller, I., Hall, M., Holmes, L., O’Shea, D.F., Wilde, C., and Gallagher, W.M. (2006) New cell-based assay for comparisons of caspase 3/7 activity in normal versus tumor cell populations. 97th Annual Meeting of the American Association of Cancer Research, Washington DC, USA (1 – 5 April 2006)
Herron, C. and Martial, M. (2006) NF-KB activation by Amyloid beta (1-40) in rat Primary Astrocytes Cultures is regulated by PPARgamma. Federation of European Neurosceinces, Vienna (July 2006)
O’Connor, D.P., O’Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., and Gallagher, W.M. (2006) p21, p16 and p27, more than just cell cycle inhibitors. Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway, Ireland (3 – 4 March 2006)
Duffy, Á.M., Glennon, J.C., Scharrenburg, G. van and O’Connor, W.T. (2006) Pallidal GABA and glutamate release in a 6-hydroxydopamine microdialysis model of parkinson’s disease. Effect of full and partial dopamine receptor agonists. 11th International Conference on Invivo Methods, Cagliara, Italy (19th – 22nd May, 2006)
Hanson, J., Dogné, J-M., Ghiotto, J., Neven, P., Kelley, L.P., Kinsella, B.T. and Pirotte, B. (2006) Pharmacological evaluation of TP receptor antagonists characterized by differential activity on alpha and beta isoforms. IUPHAR International Congress in Pharmacology, Beijing, China (July 2006)
Smyth, A.A., Kelly, J.A., Gilchrist, M.D. and O’Connor, W.T. (2006) Pharmacological manipulation of elevated glutamate levels following acute brain injury to rat frontal cortex. Western European Regional CINP Conference, Queen’s University Belfast (2nd – 4th April, 2006)
Whelan, L.C., Murphy, A., Currid, C.A., O’Connor, D., and Gallagher, W.M. (2006) ProteinChip facility at the Conway Institute: applications of SELDI-MS technology in biomedical research. BioTekNet 2006 Meeting, Dublin, Ireland
Collins, B.C., O’Connor, D.P., Currid, C.A., Chang, B., O’Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. and Gallagher, W.M. (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting. 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting, Hinxton, Cambridge, UK (12 - 14 July 2006)
Lau, T.Y., O’Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., and Gallagher, W.M. (2006) Proteomic analysis of models of breast cancer progression. 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting, Hinxton, Cambridge, UK (12 - 14 July 2006)
Lau, T.Y., O’Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., and Gallagher, W.M. (2006) Proteomic analysis of models of breast cancer progression. EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, Dublin, Ireland (6 – 8 June 2006)
O’Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O’Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., and Gallagher, W.M. (2006) Proteomic analysis of p21-regulated protein expression. Gordon Research Conference: Cancer Models and Mechanisms, Rhode Island, USA (1 - 4 August 2006)
O'Gara, J.P. (2006) Regulatory pathways controlling the Staphylococcal biofilm phenotype. Society for General Microbiology, Irish Branch Meeting, Dublin, Ireland (27th-28th April 2006)
Hedigan, K., Cassidy, A.W., Mulvany, S.K. and Regan, C.M. (2006) Relevance of Idiosyncratic Rat Preferences For Sweet Substances. Western European Regional CINP Conference, Queens University Belfast (4th April 2006)
Cassidy, A., Mulvany, S., Seymour, C., Marquis, K.L., Logue, S.F., Regan, C.M. (2006) The developmental emergence of anomalies in sensorimotor gating and exploratory behaviour in maternally deprived and isolation reared animals. Western European Regional CINP Conference, Queens University Belfast (4th April 2006)
Smyth, A., Gilchrist, M., Kelly, J.A. and O’Connor, W.T. (2006) The effects of thyrotrophin releasing hormone and MgCl2 on impact-related dialysate glutamate levels in a microdialysis model of traumatic brain injury. 11th International Conference on Invivo Methods, Cagliara, Italy (19th – 22nd May, 2006)
Bender, K., Newsholme, P., Brennan, L. and Maechler, P. (2006) The importance of redox shuttles to pancreatic b- Cell energy metabolism and function. Bioscience 2006, Glasgow, Scotland (23rd - 27th July 2006)
O'Leary, D., Grennan, G., O'Connor, J. and Herron, C. (2006) The Role of endocannabinoids in mGluR mediated Long Term Depression in the Rat Hippocampus. Royal Academy of Medicine in Ireland, UCD, Dublin (January 2006)
Sheridan, G., Pickering, M., Moynagh, P.N., O’Connor, J.J. and Murphy, K.J. (2006) Tumour necrosis factor-? selectively upregulates nuclear factor ?b expression in hippocampal sub-neuronal populations. Royal Academy of Medicine in Ireland, Section of Biomedical Sciences, UCD (12 January 2006)
Foley, A., Seymour, C.M., Murphy, K.J. and Regan, C.M. (2005) Amnesia induced by antibodies to the neural cell adhesion molecule. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Bjarnadottir, U. and Nielsen, J.E. (2005) Analysing the protein kinase activation process using molecular dynamics simulations. MGMS meeting: Biomolecular Simulations : from prediction to practice,, Trinity College Dublin (Sept 11-14th, 2005)
Conboy, L., Murphy, K.J. and Regan, C.M. (2005) Degradation of APP during the early phase of long-term memory consolidation. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M. (2005) Development of an automated screen for analysing the effects of oestrogen compounds on cell fate determination. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Cassidy, A., Mulvany, S.K., Seymour, C.M., Marquis, K.L., Logue, S.F. and Regan, C.M. (2005) Developmental progression of sensorimotor gating deficits in two models of schizophrenia and the impact of an atypical neuroleptic, clozapine. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2005) Differential neuroplastic marker expression in the dentate gyrus following learning. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2005) Dorso-ventral expression of polysialylated neural cell adhesion molecule in the dentate gyrus following passive avoidance conditioning. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2005) Dorso-ventral expression of polysialylated neural cell adhesion molecule in the rat dentate gyrus following learning. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Verhaegen, S., Harris, K.A., Mulryan, L., Murphy, K.J. and Regan, C.M. (2005) In vitro screening for endocrine disruptors using murine neuronal cell models. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Loscher, J.S., Charlotte, W.T., Murphy, K.J. and Regan, C.M. (2005) Influence of rat strain and supplier on general behaviour and spatial learning.. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Seymour, C.M., Murphy, K.J., Saffell, J.L. and Regan, C.M. (2005) Inhibition of ncam-fgfr interaction disrupts avoidance conditioning and associated modulation of gsk3? activity in the rat dentate gyrus. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Rombach, N., Regan, C.M. and Murphy, K.J. (2005) Investigation of brain adaptations underlying development of a drug-dependent state. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2005) Long term storage of a passive avoidance task is not associated with synapse change in the secondary visual cortex. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (7th January 2005)
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M. (2005) Memory related synaptic change in the cerebral cortex. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Regan, C.M., Charlotte, W.T., Loscher, J.S. and Murphy, K.J. (2005) Minimal change to rodent housing affects behaviour and brain structure. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Gannon, S., Conboy, L. and Regan, C.M. (2005) Psychoscreen: A new path for drug discovery in psychopharmacology. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Mulryan, L., Murphy, K.J. and Regan, C.M. (2005) Screening for the detection of endocrine disrupting chemicals. Irish J Med Sci, 174, 30. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
Thomas, C.M., Murphy, K.J. and Regan, C.M. (2005) Synaptic modifications underlying memory formation. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
O’Sullivan, N.C., Conboy, L., Regan, C.M. and Murphy, K.J. (2005) Transcriptional events in rat dentate gyrus following passive avoidance learning. RAMI Section of Biomedical Sciences Winter Meeting, Trinity College Dublin (7th January 2005)
O’Sullivan, N.C., Conboy, L., Regan, C.M. and Murphy, K.J. (2005) Transcriptional regulation following passive avoidance learning. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Moran, M.P., De Souza, I.E.J., Brady, A.T., Kenny, C.M., O’Keeffe, M.A., McCabe, O.M., Mulvany S.K. and O’Connor, W.T. (2005) A physiological and behavioral investigation of two animal models of schizophrenia: effect of enviornment and clozapine. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Moran, M., De Souza, I.E.J., Brady, A., Kenny, C., O’Keeffe, M.A., McCabe, O. Earley, B.E., Mulvany, S.K. and O’Connor, W.T. (2005) A physiological and behavioral investigation. of two animal models of schizophrenia: effect of environment and clozapine. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
O’Neill, C., Nolan, B.O’Boyle, K., O’Connor, J.J. (2005) Adenosine receptor activation modulates electrically evoked dopamine release in the rat striatum in vitro: studies using fast cyclic voltammetry. Conway Institute Festival of Research, UCD (15 September 2005)
Butler, S., Reilly, R., Wellstead, P. and O’Connor, W.T. (2005) An integrated software toolkit for the visualisation of microdialysis data. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
De Souza, I.E.J., Brady, A.T., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany S.K. and O’Connor, W.T. (2005) Basal and pergolide stimulated medial prefrontal GABA release in two rat models of schizophrenia: effect of clozapine and environment. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Kenny, C.M. De Souza, I.E.J. Brady, A.T., O’Keeffe, M., McCabe, O.M., Moran, M. P., Duffy, A.M., Mulvany, S.K. and O’Connor, W.T. (2005) Basal but not KCl-stimulated medial prefrontal aspartate release is reduced by clozapine: a microdialysis study in two rat models of schizophrenia. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
O'Gara, J. P. (2005) Biofilm regulation in Staphylococci. Masaryk University Medical School Stomatology Research Conference, Brno, Czech Republic (15th -17th November 2005)
Butler, G. (2005) Candida parapsilosis: genomic analysis and biofilm development. in: Cherry, J.M., Kolarov, J., Tomaska, L ed(s). 22nd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovakia (26-31 August, 2005)
Smyth, A., Gilchrist, M.D., Kelly, J. A. and O’Connor, W.T. (2005) Changes in medial prefrontal and ventral tegmental glutamate release following a mild prefrontal injury in the rat: effects of TRH. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
Coyle, A.T. and Kinsella, B.T. (2005) Characterization of promoter 3 of the human thromboxane A2 receptor gene. Experimental Biology 2005,, San Diego, CA, USA (April 2005)
Kenny, C., De Souza, I.E.J., Brady, A., O’Keeffe, M.A, McCabe, O., Moran, M., Duffy, A., Mulvany S.K. and O’Connor, W.T. (2005) Clozapine reduces basal but not kcl-stimulated medial prefrontal aspartate release. a microdialysis study in two animal models of schizophrenia. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
Pickering, M. and O’Connor, J.J. (2005) Comparison of the information changes between up-regulated and recruited synapses in LTP using a biophysical cell model. Conway Institute Festival of Research, UCD (15 September 2005)
De Souza, I.E.J., Brady, A., O’Keeffe, M., Kenny, C., McCabe, O., Moran, M., Duffy, A., Fitzgerald, C., Mulvany S.K. and O’Connor, W.T. (2005) Differential effect of environment and clozapine on basal and stimulated medial prefrontal GABA release in two animal models of schizophrenia. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
Davey, L., McMorrow, T. and Ryan, M.P. (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
Agostini, L., Nielsen, J.E. (2005) EATDB: Enzyme Analysis Tool and DataBase. MGMS meeting: Biomolecular Simulations : from prediction to practice,, Trinity College Dublin (Sept 11-14th, 2005)
Smyth, A., Gilchrist, M.D. and O’Connor, W.T. (2005) Effect of magnesium chloride perfusion into the medial prefrontal cortex on GABA levels following a mild traumatic brain injury. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Brady, A.T., De Souza, I.E.J., McCabe, O.M., Moran, M.P., Duffy, A.M., Mulvany, S.K. and O’Connor, W.T. (2005) Effect of pergolide on basal hypoglutamatergia in the rat medial prefrontal cortex in two models of schizophrenia. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Brennan, L., Hewage, C., Malthouse, J.G., McCenaghan, N.H., Flatt, P.R. and Newsholme P. (2005) Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11. EASD, Athens, Greece (12-15 September)
Duffy, Á.M., Glennon, J.C., Scharrenburg, G. van and O’Connor, W.T. (2005) Effects of the partial dopamine D2 receptor agonist terguride on GABA and glutamate release in the globus pallidus of intact and 6-OHDA lesioned rat brain. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Donnelly, C. and Murphy, C.D. (2005) Enzymatic defluorination of fluoroglutamate. Biochemical Society/Pro-Bio Faraday Annual Conference: Biocatalysis: Enzymes, Mechanisms and Bioprocesses, Manchester, UK (21-22 November 2005)
Brady, A., De Souza, I.E.J., O’Keeffe, M.A., Kenny, C., McCabe, O., Moran, M., Duffy, A., Mulvany, S.K. and O’Connor, W.T. (2005) Evidence for a medial prefrontal hypoglutamatergia in two animal models of schizophrenia. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
McCabe, O., De Souza, I.E.J., Brady, A., O’Keeffe, M.A., Kenny, C., Moran, M., Duffy, A., Mulvany, S.K. and O’Connor, W.T. (2005) Evidence for an alteration in the ratio of excitatory and inhibitory transmission in the medial prefrontal cortex in two animal models of schizophrenia. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
Tuite, N.M., McMorrow, T. and Ryan, M.P. (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., and Dervan, P.A. (2005) Genetic determinants of progression of ductal carcinoma in situ to invasive breast cancer. 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET), Dublin, Ireland (03/11/2005)
Rossignol, T., Logue, M.E. and Butler, G. (2005) Genome sequence survey and design of microarrays for Candida parapsilosis.. in: Cherry, J.M., Kolarov, J., Tomaska, L ed(s). 22nd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovakia (26-31 August, 2005)
Cumiskey, D. and O’Connor, J.J. (2005) Group 1 mGlur’s mediate the inhibitory effect of tumour necrosis factor-alpha on long-term potentiation and NMDA epsps. Conway Institute Festival of Research, UCD (15 September 2005)
Heffernan, B., Phenlan, S., Murphy, C.D. and Casey, E. (2005) Investigation of the interactions between biological and physico-chemical processes in a Pseudomonas fluorescens biofilm. Recent Advances in Chemical Biology IV, Dublin, Ireland (2 December 2005)
Cummins, E., Gallagher, W.M., O’Brien, E., Stanton, A., Cagney, G., and Cahill, D.J. (2005) Metabolic syndrome biomarker discovery by surface enhanced laser desorption/ionisation time-of-flight mass spectrometry. HUPO 4th Annual World Congress, Berlin, Germany (28 August – 1 September 2005)
Faller, W., Rafferty, M., Fraga, M., Esteller, M., and Gallagher, W. (2005) Methylation profiling of markers for melanoma progression. 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET), Dublin, Ireland (03/11/2005)
McSherry, E.A., Rafferty, M., Gallagher, W.M., Dervan, P.A. and Hopkins, A.M. (2005) Modelling breast cancer progression via integrated 2- and 3-dimensional cell culture systems. AACR Special Conference in Cancer Research – Advances in Breast Cancer Research: Genetics, Biology and Clinical Applications, La Jolla, CA, USA (21 – 25 September 2005)
O’Connor, W.T. (2005) Novel active handouts in the teaching and learning of brain function. European Conference on Educational Research, University College Dublin (7th-10 th September, 2005)
McGee, S., McArdle, E., O’Brien, S., Martin, F., O’Connor, D. and Gallagher, W. (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes. 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET), Dublin, Ireland (03/11/2005)
McGee, S., McArdle, E., O’Brien, S., Martin, F., O’Connor, D. and Gallagher, W.M. (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes. Cold Spring Harbor Laboratory Conference: RNA Interference, New York, USA (28 September – 2 October 2005)
Johnston, O., O’Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P. (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
O’Connor, W.T., Smyth, A. and Callanan, J. J. (2005) Probing structural and functional sequellae of brain injury in rat prefrontal cortex following controlled cortical impact. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
O’ Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P. (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
Currid, C., O’Connor, D.P., Gebus, C., Chang, B.-D., Harris, N., Dawson, K., Pennington, S.R., Roninson, I.B., and Gallagher, W.M. (2005) Proteomic analysis of factors released from p21-overexpressing tumour cells. HUPO 4th Annual World Congress, Berlin, Germany (28 August – 1 September 2005)
Webb, H., Nielsen, J.E. (2005) Proton donor identification using protein pKa calculations. MGMS meeting: Biomolecular Simulations : from prediction to practice,, Trinity College Dublin (Sept 11-14th, 2005)
McCabe, O.M., De Souza, I.E.J., Brady, A.T., Moran, M., Duffy, A.M., Mulvany S.K. and O’Connor, W.T. (2005) Ratios of excitatory and inhibitory neurotransmission in the rat medial prefrontal cortex in two models of schizophrenia - basal and pergolide induced changes. The Irish Neuroscience Group Meeting, Tullamore, Co. Offally (4th – 5th November, 2005)
Tynan-Connolly, B., Nielsen, J.E. (2005) Re-Designing protein pKa values. MGMS meeting: Biomolecular Simulations : from prediction to practice,, Trinity College Dublin (Sept 11-14th, 2005)
McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P. (2005) RNA interference: A novel alternative approach in nephrotoxicity studies. 5th World Congress of Alternatives to Animal experimentation, Berlin, Germany (21-25 August 2005)
O’Neill, C., Nolan, B., O’Boyle, K.M. and O’Connor, J.J. (2005) SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices. British Pharmacological Society Winter meeting, London (20-22 December 2005)
Smyth, A., Gilchrist, M.D., Callanan, J.J. and O’Connor, W.T. (2005) Structural and functional sequellae of brain injury in rat prefrontal cortex following controlled cortical impact. National Congress of the Italian Society for Neuroscience and Joint Italian-Swedish Neuroscience Meeting, Ischia (Naples), Italy (1st-4th October, 2005)
O’Connor, W.T. (2005) The Active Handout: A Valuable Aid In The Teaching Of Neuroscience. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
Hutchinson, R.I., Grant, R. and Murphy, C.D. (2005) The biochemistry of 4-amino-3-chloro-2-pentenedioic acid (ACPA) in Streptomyces viridogenes. Recent Advances in Chemical Biology IV, Dublin, Ireland (2 December 2005)
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M. (2005) The development of an automated screening system for analysing the effects of 17-b-estradiol and other estrogenic compounds on stem cell fate. 37th Annual General Meeting of the European Brain and Behaviour Society, Trinity College Dublin (24-28 September 2005)
Duffy, A.M., Glennon, J.C., Scharrenburg, G. van and O’Connor, W.T. (2005) The effect of full and partial dopamine D2 receptor agonists on striopallidal GABA-mediated inhibition of subthalamic-pallidal glutamate release in the awake rat. 35th Annual Meeting of the Society for Neuroscience, Washington, DC (12th-16th November, 2005)
O'Connell, S., Tuite, N. and Ryan, M.P. (2005) The effect of immunosuppressive agents on human mesangial cells. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
Sheridan, G., Pickering, M., Moynagh, P.N., O’Connor, J.J. and Murphy, K.J. (2005) The pro-inflammatory cytokine tumour necrosis factor-? selectively upregulates nuclear factor ?b expression in hippocampal sub-neuronal populations. British Pharmacological Society Winter meeting, London (20-22 December 2005)
O’Leary, D., Grennan, G.Z., O’Connor, J.J. and Herron, C.E. (2005) The Role of Arachidonic Acid Metabolites in mGluR mediated Long Term Depression in the Rat Hippocampus. Conway Institute Festival of Research, UCD (15 September 2005)
O’Leary, D.M., Grennan, G.Z., O’Connor, J.J. and Herron, C.E. (2005) The role of arachidonic acid signalling in mGluR mediated long term depression in the rat hippocampus. British Pharmacological Society Winter meeting, London (20-22 December 2005)
O'Leary, D., Grennan, G., O'Connor, J. Herron, C. (2005) The role of endocannabinoids in mGluR mediated long term depression in the rat hippocampus. British Pharmacological, London (Dec 2005)
Slattery, C., McMorrow, T. and Ryan, M.P. (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis. C Slattery,. American Society of Nephrology, Philadelphia, USA (9-13 November 2005)
