Warhol's cells. Image by Mr Carlo Sala Frigerio.
School of Biomolecular & Biomedical Science - Research Publications 2006/07
Below is the list of research publications for the School of Biomolecular & Biomedical Science in the academic year 2006/07
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| Professor Geraldine Butler | |
| Butler. G. (2007) 'The evolution of MAT - the ascomycetes' In: J. Heitman, J. Kronstad, J. Taylor, L. Casselton (eds). Sex in fungi: Molecular determination and evolutionary implications. Washington, DC: ASM Press. | |
| Butler G. and Sullivan D.J. (2007) 'Comparative genomics of Candida species' In: B. Hube and C. d'Enfert (eds). Candida: comparative and functional genomics. Norfolk, U.K: Caister Academic Press. | |
| Dr Patricia Maguire | |
| Maguire PB, Belton O, O’Donoghue N & Coppinger JC. (2006) 'Platelet-endothelial interactions' In: Aird, W.C (eds). The Endothelium: A Comprehensive Reference. Cambridge, UK: Cambridge Univerity Press. | |
| Dr Gethin McBean | |
| McBean G. (2007) 'Sulfur-containing amino acids' In: Lajtha A., Oja S., Schousboe A. and Saransaari P (eds). Handbook of Neurochemistry and Molecular Neurobiology. Vol.4, Amino acids and peptides in the nervous system. Berlin, Heidelberg: Springer-Verlag. | |
| Dr Dominic Walsh | |
| Aedin M. Minogue, Julia V. Fadeeva, Jordan Tang, Wilma Wasco, Dennis J. Selkoe and Dominic M. Walsh (2006) 'Detection and characterization of secreted peptides derived from amyloid precursor-like protein 1 and 2' In: Eds. K Iqbal, B Winblad, J Avila, Medimond, Bologna (eds). Proceeding of the 10th Conference on Alzheimer's disease and related disorders. Bologna: Medimond. | |
| Dr Oliver Blacque | |
| Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, Schafer JC, Li C, Yoder BK,Leroux MR, Scholey JM. (2007) 'Sensory Ciliogenesis in Caenorhabditis elegans: Assignment of IFT components into Distinct Modules Based on Transport and Phenotypic Profiles'. Molecular Biology of the Cell, 18 :1554-1569. | |
| Blacque OE, Li C, Inglis PN, Esmail M, Ou G, Mah AK, Baillie DL, Scholey JM, Leroux MR. (2006) 'The WD repeat-containing protein, IFTA-1, is required for effective retrograde intraflagellar transport'. Molecular Biology of the Cell, 17 :5053-5062. | |
| Efimenko E, Blacque OE, Ou G, Haycraft CJ, Yoder BK, Scholey JM, Leroux MR, Swoboda P. (2006) 'C. elegans DYF-2, anortholog of human WDR19, is a component of the IFT machinery in sensory cilia'. Molecular Biology of the Cell. | |
| Dr Derek P Brazil | |
| Yang KJ, Shin S, Piao L, Shin E, Li Y, Park KA, Byun KA, Won M, Hong J, Kweon GR, Hur GM, Seok JH, Chun T, Brazil DP, Hemmings BA and Park J (2007) 'Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by SRC involves tyrosine phosphorylation of PDK1 and SRC SH2 domain binding'. Journal of Biological Chemistry . | |
| Barry RE, Allan BB, Cummins EP, Kattla JJ, Giblin A, Scally N, Taylor CT, Brazil DP. (2007) 'Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability'. European Journal of Cell Biology, 86 (7):393-403. | |
| Professor Geraldine Butler | |
| Ding C. and Butler G. (2007) 'Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formation'. Eukaryotic Cell, 6 :1310-1319. | |
| Rossignol T, Logue ME, Reynolds K, Grenon M, Lowndes NF, Butler G. (2007) 'Analysis of the transcriptional response of Candida parapsilosis following exposure to farnesol'. Antimicrob Agents Chemother, 51 (2304). | |
| Dignard D, El-Naggar AL, Logue ME, Butler G, Whiteway M. (2007) 'Identification and characterization of MFA1; the gene encoding Candida albicans a-factor pheromone'. Eukaryotic Cell, 6 :487-494. | |
| Fitzpatrick, DA; Logue, ME; Stajich, JE; Butler, G; (2006) 'A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis'. BMC Evolutionary Biology, 6 (NA). | |
| Mulhern, SM; Logue, ME; Butler, G; (2006) 'Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions'. Eukaryotic Cell, 5 (12):2001-2013. | |
| Dr John Crean | |
| Mitchell, DM., Gaffney, A., Crean, JK., Kinsella, BT. and Godson C (2007) 'The lipoxin A4 receptor is coupled to SHP-2 activation; implications for regulating growth factor receptor signalling'. Journal of Biological Chemistry . | |
| Furlong, F., Crean, J.K., Murphy, M., O’Leary R., and Martin, F. (2007) 'Dysregulated Intracellular Signaling Impairs CTGF Stimulated Responses in Human Mesangial Cells Exposed to High Extracellular Glucose'. American Journal of Physiology . | |
| Dr Peter Crowley | |
| K. Sato, P. B. Crowley and C. Dennison (2007) 'Transient protein interactions of Cytochrome f and the phytocyanin Umecyanin'. Chembiochem, 8 :732-735. | |
| Professor Paul Engel | |
| Paradisi, F; Collins, S; Maguire, AR; Engel, PC; (2007) 'Phenylalanine dehydrogenase mutants: Efficient biocatalysts for synthesis of non-natural phenylalanine derivatives'. Journal of Biotechnology, 128 (2):408-411. | |
| S. Chen & P.C. Engel. (2007) 'An engineered mutant, L307V, of phenylalanine dehydrogenase from Bacillus sphaericus: high activity and stability in organic-aqueous solvent mixtures and utility for synthesis of noin-natural L-amino acids'. Enzyme and Microbial Technology, 40 :1407-1411. | |
| Professor William Gallagher | |
| Rafferty, M., Faller, W. J., Moss, C., McCormick, J., Easty, D.J., and Gallagher, W. M. (2007) 'Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes'. AntiCancer Research, 27 :1301-1308. | |
| Donal J Brennan , Catherine Kelly , Elton Rexhepaj , Peter A Dervan , Michael J Duffy , William M Gallagher (2007) 'Contribution of DNA and tissue microarray technology to the identification and validation of biomarkers and personalised medicine in breast cancer'. Cancer Genomics Proteomics, 4 :121-134. | |
| Lau, TY; O'Connor, DP; Brennan, DJ; Duffy, MJ; Pennington, SR; Gallagher, WM; (2007) 'Breast cancer proteomics: clinical perspectives'. Expert Opinion on Biological Therapy, 7 (2):209-219. | |
| Smith, FM; Gallagher, WM; Fox, E; Stephens, RB; Rexhepaj, E; Petricoin, EF; Liotta, L; Kennedy, MJ; Reynolds, JV; (2007) 'Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy'. Annals of Surgery, 245 (2):259-266. | |
| Sallyann L O'Brien, Ailís Fagan, Edward J P Fox, Robert C Millikan, Aedín C Culhane, Donal J Brennan, Amanda H McCann, Shauna Hegarty, Siobhan Moyna, Michael J Duffy, Desmond G Higgins, Karin Jirström, Göran Landberg, William M Gallagher (2007) 'CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer'. International Journal of Cancer, 120 (7):1426-1435. | |
| Duffy, M. J., O’Donovan, N., Brennan, D. J., Gallagher, W. M., and Ryan, B. M (2007) 'Survivin: a promising tumor biomarker'. Cancer Letters, 249 (1):49-60. | |
| Hughes, L., O’ Brien, S., and Gallagher, W. M., and McDonnell, S. (2007) 'DNA microarray-based transcriptomic profiling of an isogenic cell culture model of breast tumour cell invasion'. Anticancer Research, 27 :1353-1360. | |
| Rafferty, M., Faller, W. J., Moss, C., McCormick, J., Easty, D. J., and Gallagher, W. M. (2007) 'Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes'. Anticancer Research, 27 :1301-1308. | |
| McGee, S. F., O'Connor, D. P., and Gallagher, W. M. (2006) 'Functional interrogation of breast cancer: from models to drugs'. Drug Discovery Today, 1 (6):569-584. | |
| Kavanagh, C.A., Gorelova, T.A., Selezneva, II., Rochev, Y.A., Dawson, K.A., Gallagher, W.M., Gorelov, A.V., Keenan, A.K. (2006) 'Poly(N-isopropylacrylamide) copolymer films as vehicles for the sustained delivery of proteins to vascular endothelial cells'. J Biomed Mater Res A, 72 (1):25-35. | |
| Dr Carmel Hensey | |
| Montesanti, A., Deignan, K., and Hensey, C. (2007) 'Cloning and characterization of Xenopus laevis Smac Diablo'. Gene, 392 (1-2):187-195. | |
| Dr Caroline Herron | |
| Cumiskey, D., Curran, B.P., Herron, C.E,. O'Connor J.J (2007) 'A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus'. Neuropharmacology, 52 (8):1616-1623. | |
| Dr Chandralal Hewage | |
| Spink E, Cosgrove S, Rogers L, Hewage C, Malthouse JP. (2007) '13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. Journal of Biological Chemistry, 282 (11):7852-7861. | |
| Higgs R, Lynn DJ, Cahalane S, Alana I, Hewage CM, James T, Lloyd AT, O'Farrelly C. (2007) 'Modification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity'. Immunogenetics, 59 (7):573-580. | |
| Alana I, Malthouse JP, O'Harte FP, Hewage CM. (2007) 'Bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. Proteins: Structure, Func. and Bioinfor, 68 (1):92-99. | |
| Dr Elena Hutchens | |
Hutchens, E., Williamson, B. J., Anand, M., Ryan, M. P., Herrington, R. J. (2007) 'Fe-isotopes differentiate bacterial and electrochemical corrosion'. Corrosion Science, 49 :3759-3764.  |
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| Hutchens, E., Valsami-Jones, E., Harouyia, N., Chaïrat C., McEldoney, S., Oelkers, E. (2006) 'Hutchens, E., Valsami-Jones, E., Harouyia, N., Chaïrat C., McEldoney, S., Oelkers, E'. Geomicrobiology Journal, 23 (3):177-182. |
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| Dr Breandán Kennedy | |
| Kennedy, B.N.; Yolanda Alvarez; Brockerhoff, S.E.; Stearns, G.; Sapetto-Rebow, B., Taylor, M.R.; and Hurley, J.B. (2007) 'Identification Of A Zebrafish Cone-Specific Promoter And Genetic Rescue Of Achromatopsia In The nof Mutant'. Invest. Ophth. Vis. Sci, (48):522-529. | |
| Professor Therese Kinsella | |
| Julien Hanson, Jean-Michel Dogné, Ghiotto Jeremie, Anne-Lise Moray, B. Therese Kinsella & Bernard Pirotte. (2007) 'Design, synthesis and SAR of a series of N-alkyl-N’-[2-(aryloxy)-5-nitrobenzenesulfonyl]- urea and –cyanoguanidines as selective antagonists of the TP a and TP b isoforms of the human thromboxane A2 receptor'. Journal of Medicinal Chemistry, 50 (16):3928-3936. | |
| Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C. (2007) 'The Lipoxin A4 Receptor Is Coupled to SHP-2 Activation: Implications for Regulation of Receptor Tyrosine Kinases'. Journal of Biological Chemistry, 282 (21):15606-15618. | |
| Reid Helen M & Kinsella B. Therese (2007) 'Palmitoylation of the TPbeta isoform of the human thromboxane A(2) receptor. Modulation of G protein: Effector coupling and modes of receptor internalization'. Cell Signal, 19 (5):1056-1070. | |
| Coyle AT, Kinsella BT. (2006) 'Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A(2) receptor gene in human erythroleukemia cells'. Biochemical Pharmacology, 71 :1308-1323. | |
| Professor Jonathan Malthouse | |
| Alana I, Malthouse JP, O'Harte FP, Hewage CM. (2007) ''Bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. Proteins, 68 (1):92-99. | |
| Spink E., Cosgrove S., Rogers L., Hewage C., Malthouse J.P.G, (2007) '13C- and1H-NMR studies of ionisations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. Journal of Biological Chemistry, 282 :7852-7861. | |
| Malthouse (2007) '13C-and 1H- NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimising inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide derived chloromethylketone and glyoxal inhibitors'. Biochemical Society Transactions, 35 :566-570. | |
| Brennan L, Hewage C, Malthouse JP, McClenaghan NH, Flatt PR, Newsholme P. (2006) 'Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism'. Febs Journal, 273 (22):5160-5168. | |
| Professor Stephen Mayhew | |
| Susana Frago, Guillermina Gon˜, Beatriz Herguedas, Jose´ Ramo´n Peregrina, Ana Serrano, Inmaculada Perez-Dorado, Rafael Molina, Carlos Go´mez-Moreno, Juan A. Hermoso, Marta Mart?´nez-Ju´ lvez, Stephen G. Mayhew, Milagros Medina (2007) 'Tuning of the FMN binding and oxido-reduction properties by neighboring side chains in Anabaena flavodoxin'. Archives of Biochemistry and Biophysics, 467 (2007):206-217. |
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| Dr Gethin McBean | |
| Montgomery, T., Boun, C., Eibauer, S., Guiry, P.J., Keenan, A.K., McBean, G.J. (2007) 'Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines'. British Journal of Pharmacology, epub ahead of print . | |
| Dr Tara McMorrow | |
| Nee L, Tuite N, Ryan MP, McMorrow T. (2007) 'TNF-Alpha and IL-1Beta-Mediated Regulation of MMP-9 and TIMP-1 in Human Glomerular Mesangial Cells'. Experimental Nephrology, 102 (2):73-86. | |
| Feldman, G., Kiely, B., Martin, N., Ryan, G., McMorrow, T. and Ryan, M.P. (2007) 'Role for TGF-Beta in cyclosporine-induced modulation of renal epithelial barrier function'. Journal of the American Society of Nephrology, 18 (6):1662-1671. | |
| Dr James McRedmond | |
| McRedmond J (2007) ''Finding drug targets through analysis of the platelet transcriptome''. Current Pharmaceutical Design, 13 (26):2662-2667. | |
| Professor Wim Meijer | |
| Smith, C.J., B.S. Danilowicz and W.G. Meijer (2007) 'Characterisation of the bacterial community associated with the surface and mucus layer of whiting'. Fems Microbial Ecology, 62 :90-97. |
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| Gawler,A.H., Beecher, J.E., Brandão, J., Carroll, N., Falcão, L., Gourmelon, M., Masterson, B., Nunes, B., Porter, J., Rincé, A., Rodrigues, R., Thorp, M., Walters, J.M., and W.G. Meijer (2007) 'Validation of host specific Bacteroidetes 16S rRNA genes as markers to determine the origin of faecal pollution in Atlantic Rim countries of the European Union'. Water Research, 41 :3780-3784. | |
| Byrne, G.A., D.A. Russell, X. Chen and W.G. Meijer (2007) 'Transcriptional regulation of the virR operon of the intracellular pathogen Rhodococcus equi'. Journal of Bacteriology, 189 :5082-5089. |
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| Muscatello, G, D.P. Leadon, A. Ocampo-Sosa, D.A. Lewis, U. Fogarty, T. Buckley, M. Klay, J.R. Gilkerson, W.G. Meijer and J.A. Vazquez-Boland (2007) 'Rhodococcus equi infection in foals: the science of 'Rattles''. Equine Veterinary Journal, 39 :470-478. | |
| Dr Cormac Declan Murphy | |
| C.D. Murphy (2007) 'Fluorophenol oxidation by fungal chloroperoxidase'. Biotechnology Letters, 29 :45-49. | |
| C.D. Murphy (2007) 'The Application of 19F NMR to Investigate Microbial Biotransformations of Organofluorine Compounds'. Omics: A Journal of Integrated Biology, 11 (3):314-324. | |
| Hutchinson, RI; Grant, RJ; Murphy, CD; (2006) 'Biosynthetic origin of [R-(Z)]-4-amino-3-chloro-2-pentenedioic acid in Streptomyces viridogenes'. Bioscience Biotechnology and Biochemistry, 70 (12):3046-3049. | |
| Dr Keith J Murphy | |
| Conboy L, Monopoli MP, O'Sullivan NC, Murphy KJ, Regan CM (2007) 'Notch signalling is transiently increased during long term memory consolidation in adult wistar rats'. Journal of Neurochemistry, 88 :342-351. | |
| O'Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O'Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ. (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 :1085-1098. | |
| Sheridan GK, Pickering M, Twomey C. Moynagh PN, O'Connor JJ, Murphy KJ. (2007) 'NF?B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning Memory, 14 :525-532. | |
| Dr Philip Newsholme | |
| Morgan, D; Oliveira-Emilio, HR; Keane, D; Hirata, AE; da Rocha, MS; Bordin, S; Curi, R; Newsholme, P; Carpinelli, AR; (2007) 'Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line'. Diabetologia, 50 (2):359-369. | |
| Calder P, Dimitriadis G and Newsholme P (2007) 'Glucose metabolism in lymphoid and inflammatory cells and tissues'. Curr Opin Clin Nutr Metab Care, 10 :531-540. | |
| Kiely A, McClenaghan NH, Flatt PR and Newsholme P. (2007) 'Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilisation but inhibit insulin secretion in a clonal pancreatic beta cell line'. Journal of Endocrinology, 195 :113-123. | |
| Newsholme P, Keane D, Welters H and Morgan N. (2007) 'Life and death decisions for the pancreatic beta cell - The role of fatty acids'. Clinical Science, 112 :27-42. | |
| Newsholme P, Haber EP, Hirabara SM, Rebelato ELO, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R. (2007) 'Diabetes associated cell stress and dysfunction – Role of mitochondrial and non-mitochondrial ROS production and activity'. Journal of Physiology, 583 :9-24. | |
| Curi, R; Newsholme, P; Procopio, J; Lagranha, C; Gorjao, R; Pithon-Curi, TC; (2007) 'Glutamine, gene expression, and cell function'. Frontiers in Bioscience, 12 (NA):344-357. | |
| Brennan, L; Hewage, C; Malthouse, JPG; McClenaghan, NH; Flatt, PR; Newsholme, P; (2006) 'Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism'. Febs Journal, 273 (22):5160-5168. | |
| Gorjão R, Verlengia R, Garcia Soriano F, Martins de Lima T, Cury Boaventura MF, Kanunfre C, Otton R, Peres CM, Sampaio SC, Folador A, Martins EF, Pithon Curi TC, Portiolli E, Newsholme P and Curi R (2006) 'Effect of DHA rich fish oil supplementation on human leukocyte function'. Clinical Nutrition, 25 :923-938. | |
| Dr Jens Erik Nielsen | |
| Dolinsky T, Czodrowski P, Li H, Nielsen JE, Jensen JH, Klebe G, Baker N (2007) 'PDB2PQR: Expanding and upgrading automated preparation of biomolecular structures for molecular simulations'. Nucleic Acids Research, 35 :W522-W525. |
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| Schubert M, Poon D, Wicki J, Tarling C, Kwan E, Nielsen JE, Withers S, McIntosh L (2007) 'Probing Electrostatic Interactions along the Reaction Pathway of a Glycoside Hydrolase: Histidine Characterization by NMR Spectroscopy'. Biochemistry, 46 (25):7383-7395. |
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| Tynan-Connolly, BM; Nielsen, JE; (2007) 'Redesigning protein pK(a) values'. Protein Science, 16 (2):239-249. | |
| Dr Kathy O'Boyle | |
| Zaric V, Doyle D, Murphy PV, O'Boyle KM. (2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'. Anticancer Research, 27 :1331-1335. | |
| Scalabrino GA/Hogan N, O'Boyle KM, Slator GR, Gregg DJ, Fitchett CM, Draper SM, Bennett GW, Hinkle PM, Bauer K, Williams CH, Tipton KF, Kelly JA (2007) 'Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone'. Neuropharmacology, 52 :1472-1481. | |
| Evers-Donnelly, A., O'Neill, C., O'Boyle, K., O'Connor, J.J. (2006) 'Modulation of dopamine release by cannabinoid receptor activation in rat striatal slices'. Irish Journal of Medical Science, 175 (3). | |
| O'Neill, C., Nolan, B., O'Boyle, K., O'Connor, J.J. (2006) 'SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices'. British Journal of Pharmacology, 3 (4). | |
| Nolan B and O'Boyle KM (2006) 'Effects of adenosine receptor ligands on D1 dopamine receptors in rat striatum'. Irish Journal of Medical Science, 175 (1). | |
| Dr Darran O'Connor | |
| Lau, TY; O'Connor, DP; Brennan, DJ; Duffy, MJ; Pennington, SR; Gallagher, WM; (2007) 'Breast cancer proteomics: clinical perspectives'. Expert Opinion on Biological Therapy, 7 (2):209-219. | |
| Gallagher WM, Lynch I, Allen LT, Miller I, Penney SC, O'Connor DP, Pennington S, Keenan AK, Dawson KA. (2006) 'Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies'. Journal of Biomaterials, 27 (35):5871-5882. | |
| McGee SF, O’Connor DP & Gallagher WM. (2006) 'Functional interrogation of breast cancer: from models to drugs'. Drug Discovery Today, 1 (6):569-584. | |
| Dr John O'Connor | |
| Cumiskey D., Curran B.P., Herron, C.E, O’Connor J.J (2007) 'A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus'. Neuropharmacology, 52 (8):1616-1623. | |
| O’Sullivan N.C., McGettigan P.A., Sheridan, G.K., Pickering, M., Conboy, L., O’Connor, J.J., Moynagh, P.N., Higgins, D.G., Regan, C.M., Murphy, K.J. (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 (4):1085-1098. | |
| Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O’Connor, J.J., Murphy, K.J. (2007) 'NFkB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning Memory, 14 (8):525-532. | |
| Cumiskey D., Pickering M., O’Connor J.J. (2006) 'Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists'. Neuroscience Letters, 412 (3):206-210. | |
| Cumiskey, D., Butler, M.P., Moynagh, P.N. & O'Connor, J.J. (2006) 'Evidence for a role for the group 1 metabotropic glutamate receptor in the inhibitory effect of tumour necrosis factor-a on long-term potentiation'. Brain Research, 1136 (1):13-19. | |
| Dr Kevin O'Connor | |
| Tobin, KM; O'Leary, ND; Dobson, ADW; O'Connor, KE; (2007) 'Effect of heterologous expression of phaG [(R)-3-hydroxyacyl-ACP-CoA transferase] on polyhydroxyalkanoate accumulation from the aromatic hydrocarbon phenylacetic acid in Pseudomonas species'. Fems Microbiology Letters, 268 (1):9-15. | |
| McMahon A. E.M. Doyle and K. E. O’Connor (2007) 'Biochemical characterisation of the coexisting tyrosinase and laccase in the soil bacterium Pseudomonas putida F6'. Enzyme and Microbial Technology, 40 :1435-1441. | |
| Nolan L and K..E. O’ Connor (2007) 'Use of bacterial cells expressing toluene-4-monooxygenase and cell free tyrosinase for the synthesis of 4-fluorocatechol from fluorobenzene'. Biotechnology Letters, 29 :1045-1050. | |
| Tobin K. M. , John W. McGrath, Alan Mullan and Kevin E. O’ Connor (2007) 'Polyphosphate accumulation by Pseudomonas putida CA-3 and other medium chain length polyhydroxyalkanoate accumulating bacteria under aerobic growth conditions'. Applied Environmental Microbiology, 73 :1383-1387. | |
| Dr James O'Gara | |
| O'Gara, JP (2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'. Fems Microbiology Letters, 270 :179-188. | |
| Handke, L. D., S. R. Slater, K. M. Conlon, S. T. O'Donnell, M. E. Olson, K. A. Bryant, M. E. Rupp, J. P. O'Gara, and P. D. Fey (2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'. Canadian Journal of Microbiology, 53 :82-91. | |
| O'Neill, E., Pozzi, C., Houston, P., Smyth, D., Humphreys, H., Robinson, D. A., O'Gara J, P. (2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'. Journal of Clinical Microbiology, 45 :1379-1388. | |
| Professor Ciaran Regan | |
| Conboy L, Seymour CM, Monopoli MP, O’Sullivan NC, Murphy KJ, Regan CM (2007) 'Notch signalling becomes transiently attenuated during long term memory consolidation in adult Wistar rats'. Neurobiology of Learning and Memory, 88 :342-351. | |
| Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Michael Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst W, Jennings C, Jones DNC, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM (2007) 'GSK189254 - a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer’s Disease brain and improves cognitive performance in preclinical models'. Journal of Pharmacology and Experimental Therapeutics, 321 :1032-1045. | |
| Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Oceipka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, Wald JA, White T, Wilson DM, Orlek B (2007) 'Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia'. Biochemical Pharmacology, 73 :1182-1194. | |
| O’Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O’Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 :1085-1098. | |
| Hirst, WD; Stean, TO; Rogers, DC; Sunter, D; Pugh, P; Moss, SF; Bromidge, SM; Riley, G; Smith, DR; Bartlett, S; Heidbreder, CA; Atkins, AR; Lacroix, LP; Dawson, LA; Foley, AG; Regan, CM; Upton, N; (2006) 'SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models'. European Journal of Pharmacology, 553 (1-3):109-119. | |
| Dr Gavin Eamon Ryan | |
| Hess, P. et al. (2007) 'Isolation and purification of AZAs from naturally contaminated materials, and evaluation of their toxicological effects (ASTOX)'. Marine Environment & Health Series, 27 . | |
| Feldman, G., Kiely, B., Martin, N., Ryan, G., McMorrow, T., Ryan, M.P. (2007) 'Role for TGF-Beta in cyclosporine-induced modulation of renal epithelial barrier function'. Journal of the American Society of Nephrology, 18 (6):1662-1671. | |
| Dr Dominic Walsh | |
| Wesley Farris, Sonja Schütz, John R. Cirrito, Ganesh M. Shankar, Xioayan Sun,Patrick C. May, Ana George, Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, Dennis J. Selkoe (2007) 'Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy'. American Journal of Pathology, 171 (1):241-251. | |
| Ganesh M. Shankar, Matthew Townsend, Dominic M. Walsh, Dennis J. Selkoe and Bernardo L. Sabatini (2007) 'Natural oligomers of the Alzheimer amyloid-beta protein lower dendritic spine density and synapse number in hippocampus'. Journal of Neuroscience, 27 :2866-2875. | |
| Dominic M. Walsh and Dennis J. Selkoe (2007) 'Abeta oligomers - a decade of discovery'. Journal of Neurochemistry, 101 :1172-1180. | |
| Dr Derek P Brazil | |
| Roxburgh SA, Murphy M, Pollock CA, Brazil DP (2006) 'Recapitulation of Embryological Programmes in Renal Fibrosis - The Importance of Epithelial Cell Plasticity and Developmental Genes' Nephron Physiol, 103 :139-148. | |
| Professor Paul Engel | |
| Wang, X.T., Lam V.M.S. & Engel, P.C. (2006) 'Functional properties of two mutants of human glucose 6-phosphate dehydrogenase, R393G and R393H, corresponding to the clinical variants G6PD Wisconsin and Nashville' Biochimica et Biophysica Acta (Molecular Basis of Disease), 1762 :767-774. | |
| Paradisi, F., Collins, S., Maguire, A.R. & Engel, P.C. (2006) 'The use of phenylalanine dehydrogenase mutants as efficient catalysts for the synthesis of non-natural amino acids: scale-up process' . | |
| Dr Chandralal Hewage | |
| Cadogan, J.I., Hewage, C.M., McNab, H., Macpherson, A.D., Nicolson, I.S., Reed, D., Sadler, I.H. (2006) 'Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals' Org Biomol Chem, 4 (12):2446-2451. | |
| Alana, I., Parker, J.C., Gault, V.A., Flatt, P.R., O'Harte, F.P., Malthouse, J.P., Hewage, C.M. (2006) 'NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water' J. Biol. Chem, 281 (24):16370-16376. | |
| Dr Orina Belton | |
| McClelland S, Ballou L, Fitzgerald D, Belton O (2007) COX-2 gene deletion increases advanced aortic arch atherosclerosis in the apoE-/- mouse model 8th Annual Conference on Atherosclerosis Thrombosis and Vascular Biology, | |
| McClelland S, Fitzgerald D, Belton O (2007) Conjugated linoleic acid alters the pro-atherosclerotic phenotype of the monocyte/macrophage- evidence for the involvement of a novel signalling pathway European Atherosclerosis Society 76th Congress, | |
| Dr Damien Brady | |
| M.M. O'Connor, D.B. Brady, R.M. Halpin, A. McMahon, E.D. O'Riordan, M. O'Sullivan (2007) Use of enzyme-treated dairy powders to inhibit the growth of food-associated microorganisms annual meeting and food expo of the Institute of Food Technologists (IFT), Chicago, Illinois, | |
| M.M. O'Connor, D.B. Brady, R.M. Halpin, A. McMahon, E.D. O'Riordan, M. O'Sullivan (2007) Antimicrobial effect of dairy powders on Streptococcus mutans 160th Meeting of the Society for General Microbiology, University of Manchester, | |
| R.M. Halpin, M.M. O'Connor, A. McMahon, E.D. O'Riordan, M. O'Sullivan, D.B. Brady (2007) Naturally Occurring Foodstuffs Inhibit Adhesion of Streptococcus mutans to Hydroxylapatite annual meeting and food expo of the Institute of Food Technologists (IFT), Chicago, Illinois, | |
| R.M. Halpin, M.M. O'Connor, A. McMahon, E.D. O'Riordan, M. O'Sullivan, D.B. Brady (2007) Enzyme-modified and Unmodified Buttermilk Powder and Cream Powder Can Inhibit Cariogenic Streptococci Adhering to Hydroxylapatite 160th Meeting of the Society for General Microbiology, University of Manchester, | |
| R.M. Halpin, M.M. O'Connor, A. McMahon, E.D. O'Riordan, M. O'Sullivan, D.B. Brady (2007) Inhibition of Adhesion of Streptococcus mutans to Hydroxyapatite by Enzyme-treated and Untreated Whey Products Journal of Applied Microbiology, | |
| Dr Jana Haase | |
| Grudzinska J., Malynn S., Müller H., Corbett D. and Haase J. (2007) ANALYSIS OF SEROTONIN TRANSPORTER INTERACTING PROTEINS - A PROTEOMIC APPROACH LifeSciences2007, | |
| Grudzinska J, Malynn S, Müller H, Haase J (2006) ANALYSIS OF SEROTONIN TRANSPORTER INTERACTING PROTEINS - A PROTEOMIC APPROACH Neuroscience Ireland Inaurgural Conference, | |
| Dr Elena Hutchens | |
| Hutchens E., Williamson, B., J., Anand M., Ryan, M, P., Herrington R. J. (2007) Bacteria-materials interactions and Fe isotope fractionation - discriminating MIC from electrochemical corrosion European Geosciences Union Conference, Vienna (Austria), | |
| Hutchens, E., Clipson, N, McDermott, F. (2007) What can NDA tell us about mineralization of mineral surfaces? European Geosciences Union Conference, Vienna (Austria), | |
| Hutchens E., Williamson, B., J., Anand M., Ryan, M, P., Herrington R. J. (2007) Biocorrosion of cast ion by Thiomonas sp. WJ68 – use of Fe-isotope fractionation to detect biological versus chemical processes Biocorys–International Conference on biocorrosion of materials, Paris (France), | |
| Professor Therese Kinsella | |
| Helen M. Reid & B. Therese Kinsella (2007) Palmitoylation of the TP? isoform of the human thromboxane A2 receptor LifeSciences2007, Glasgow, UK, | |
| Anne-Marie Gannon & B. Therese Kinsella (2006) Molecular Characterisation of Promoter 1 of the Human Thromboxane A2 Receptor Gene Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, | |
| Dr James McRedmond | |
| McRedmond J, Sewell L, Sullivan M, Edwards R, Cagney G. (2007) 'Protein Interaction Partners of Human 14-3-3 Protein Isoforms' Molecular and Cellular Proteomics, | |
| McRedmond J, O'Donoghue, N, Sullivan M, Cagney G. (2006) 'Protein movement during platelet activation revealed using shotgun proteomics of subcellular compartments' Molecular and Cellular Proteomics, | |
| Professor Wim Meijer | |
| Miranda-CasoLuengo, R. and W.G. Meijer (2007) A novel signal transduction system in mycolic acid-containing bacteria International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom, | |
| Finn, C., X. Chen and W.G Meijer. (2007) Virulence protein networks of Rhodococcus equi International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom, | |
| Chen X, Yang J and Meijer W.G. (2007) Identification of sensor kinase interacting with VirS encoded by the virulence plasmid of Rhodococcus equi International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom, | |
| Finn, C.E., X. Chen & W.G. Meijer (2007) Protein networks of Rhodococcus equi 160th Meeting of the Society for General Microbiology P MI 34, | |
| Fahey, R. and W.G. Meijer. 2007 (2007) An investigation into the extent and function of sigma factors in the genome of Rhodococcus equi 160th Meeting of the Society for General Microbiology. P. PS 11, | |
| Dr Keith J Murphy | |
| O’Sullivan NC, McGettigan PA, Croydon L, Sheridan GK, Pickering M, Ring RH, von Schack D, Higgins DG, Regan CM, Murphy KJ (2007) Cell type- and region-specific regulation of nuclear factor kappa-B p65 activity in the hippocampus during consolidation of an avoidance conditioning task Society for Neuroscience Annual Meeting 2007, | |
| Nic Raghnaill, Monopoli MP, O’Sullivan NC, Loscher JS, Pennington S, Dunn MJ, Regan CM, Murphy KJ (2007) Hippocampal protein expression changes associated with consolidation of spatial memory characterised using two dimensional electrophoresis Society for Neuroscience Annual Meeting 2007, | |
| Sheridan G, Pickering M, Moynagh PN, O’Connor JJ, Murphy KJ (2007) Temporal changes in nuclear factor kappa-B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience Annual Meeting 2007, | |
| Loscher JS, Pickering B, Pickering M, Murphy KJ (2007) The nootropic nefiracetam prevents isoflurane-induced post-operative cognitive dysfunction (pocd) in aged wistar rats Society for Neuroscience Annual Meeting 2007, | |
| Connole L, O’Sullivan NC, Connellan J, Regan CM, Marquis KL, Menelas N. Pangalos MN, Bates B, von Schack D, Beyna M, Murphy KJ, Ring RH (2007) Midkine is a learning-associated peptide with potent effects on hippocampal neurite outgrowth and synaptogenesis Society for Neuroscience Annual Meeting 2007, | |
| O’Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M (2007) TNFalpha-mediated modulation of glutamate excitotoxicity and ischemic preconditioning is time and sequence of TNFalpha and glutamate exposure-dependent Society for Neuroscience Annual Meeting 2007, | |
| Halley P, Connole LM, O’Sullivan NC, Loscher JS, Rombach N, Ford R, Ring RH, von Schack D, Pangalos MN, Regan CM, Murphy KJ (2007) Alzheimer’s disease-associated proteins are regulated at a transcriptional level in the hippocampus during spatial memory consolidation Society for Neuroscience Annual Meeting 2007, | |
| von Schack D, Connole L, Halley P, O’Sullivan NC, Li C, Rombach N, Hill AA, Ford R, Marquis KL, Brown EL, Pangalos MN, Regan CM, Ring RH, Murphy KJ (2007) Characterization of temporal transcriptional programs accompanying memory consolidation in the hippocampus Society for Neuroscience Annual Meeting 2007, | |
| ter Horst JPF, Loscher JS, Regan CM, Murphy KJ (2007) Expression of NCAM polysialylation in the rat prefrontal cortex in learning and disease 8th IBRO congress, | |
| Monopoli MP, Pennington S, Dunn MJ, Murphy KJ (2007) Use of two dimensional electrophoresis to characterise the hippocampal memory consolidation proteome 8th IBRO congress, | |
| Dr Philip Newsholme | |
| Kiely AM, Flatt PR and Newsholme P (2007) Pro-inflammatory cytokines inhibit insulin secretion but increase glucose consumption, lactate production, triacylglycerol utilisation and AMPK activation in a clonal pancreatic beta cell line . In: Diabetologia Vol 50 Spplement 1 eds. EASD 43rd Annual meeting, Amsterdam, Holland, S229 - S229 | |
| Brennan L, Scullion, SM, Mion B, Hewage C, Malthouse JPG, Flatt P, Newsholme P and McClenaghan NH (2007) Prolonged alanine exposure induces changes in metabolism Ca2+ handling and dsensitization of insulin secretion in clonal pancreatic beta cells . In: Diabetologia Vol 50 Spplement 1 eds. EASD 43rd Annual Meeting, S214 - S214 | |
| Keane D and Newsholme P (2007) Analysis of specific arachidonic acid induced changes in gene and protein expression in a clonal rat pancreatic beta cell line . In: Diabetologia Vol 50 Spplement 1 eds. EASD 43rd Annual Meeting, Amsterdam, Holland, S171 - S171 | |
| Bender K, Maechler P and Newsholme P (2007) The effect of over expression of the mitochondrial Aspartate-Glutamate exchanger Aralar 1 on insulin secretion and metabolism in the BRIN BD11 cell line . In: Diabetologia Vol 50 Spplement 1 eds. EASD 43rd Annual meeting, Amsterdam, Holland, S220 - S220 | |
| Dr Jens Erik Nielsen | |
| Tynan-Connolly B, Webb H, O'Meara F, McIntosh LP, Nielsen JE (2007) Altering The pKa Values Of HEWL using pKD and 1H-15N HSQC Spectroscopy Keystones Conference: Frontiers of NMR in Molecular Biology. Keystones Conference, Snowbird Resort, Snowbird, Utah. Jan 6-10, 2007, | |
| Georgi N, Farrell D, O’Meara F, Webb H, Tynan-Connolly BM, Bjarnadottir U, Soendergaard C, Nielsen JE (2007) Structural analysis of datasets from protein engineering studies using PEAT Proteins: From Birth to Death 21st Annual Symposium of The Protein Society, July 21-25, 2007, Boston, MA, USA, | |
| Tynan-Connolly BM, Nogueira E, O’Meara F, Nielsen JE (2007) Modifying the pKa values in Hen Egg White Lysozyme using pKD and 1H-15N HSQC Spectroscopy Proteins: From Birth to Death 21st Annual Symposium of The Protein Society, July 21-25, 2007, Boston, MA, USA, | |
| Una Bjarnadottir, Tommy Carstensen, Jens Erik Nielsen (2007) Detailed Analysis of the Dynamics of cAMP Dependent Protein Kinase using Molecular Dynamics Simulations and Normal Mode Analysis Proteins: From Birth to Death. 21st Annual Symposium of The Protein Society, July 21-25, 2007, Boston, MA, USA, | |
| Chresten Soendergaard, Lawrence P. McIntosh, Gianluca Pollastri, Jens Nielsen (2007) Determination of electrostatic interaction energies and protonation state populations in enzyme active sites by global fits of NMR- titration data and pH-activity profiles Proteins: From Birth to Death 1st Annual Symposium of The Protein Society, July 21-25, 2007, Boston, MA, USA, | |
| Bradley J, Salbo R, Nielsen JE (2007) HEWL amyloidgenesis Proteins: From Birth to Death 21st Annual Symposium of The Protein Society, July 21-25, 2007, Boston, MA, USA, | |
| Carstensen T, Nielsen JE (2007) Prediction of residues important for protein dynamics. A normal mode analysis approach Frontiers of NMR in Molecular Biology, Snowbird, Utha, Jan 6-10, 2007, | |
| Sondergaard CR, Pollastri G, Nielsen JE (2006) Comparing machine learning and empirical methods for scoring of protein-ligand binding energies The 16th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modelling The Mediterranean Sea, 10th-17th September 2006, | |
| Dr John O'Connor | |
| Cumiskey, D., O' Connor, J.J. (2006) A role for mGluRs and Ca2+ in the inhibitory effect of tumour necrosis factor-a on long-term potentiation British Journal of Pharmacology. Vol 3, Issue 4, 055P, | |
| Sheridan G., Pickering M., Moynagh P.N., O'Connor J.J. and Murphy K.J. (2006) Tumour necrosis factor-? selectively upregulates nuclear factor ?b expression in hippocampal sub-neuronal populations British Journal of Pharmacology, Vol 3, Issue 4, 113P, | |
| Cumiskey, D., O' Connor, J.J. (2006) The role of metabotropic glutamate receptors in the inhibitory effect of interleukin-18 on long-term potentiation Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), 53 | |
| Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), 40 | |
| Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J. (2006) GABA receptor blockade increases NF?b activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), 78 | |
| Pickering, M., Pickering, B.W., Murphy, K.J., O'Connor, J.J. (2006) Discrimination of neurones and glia using calcium imaging in primary mixed cell culture models of glutamate excitotoxicity Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), 100 | |
| Evers-Donnelly, A., O'Neill, C., O'Boyle, K., O'Connor, J.J. (2006) Modulation of dopamine release by cannabinoid receptor activation in rat striatal slices Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), p41, | |
| O'Neill C., Nolan B., O'Boyle K.M. and O'Connor J.J. (2006) SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices British Journal of Pharmacology. Vol 3, Issue 4, 067P, | |
| O'Leary D.M., Grennan G.Z., O'Connor J.J. and Herron C.E. (2006) The role of arachidonic acid signalling in mGluR mediated long term depression in the rat hippocampus British Journal of Pharmacology, Vol 3, Issue 4, 152P, | |
