'Contamination- Not always the Ugly side of Science Research'. Image by Ms Catherine Daly.
School of Biomolecular & Biomedical Science - Research Publications 2007/08
Below is the list of research publications for the School of Biomolecular & Biomedical Science in the academic year 2007/08
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| Dr John O'Connor | |
| Pickering, M. & O'Connor J.J (2007) 'Cytokines and their effects in the dentate gyrus' In: Scharfman, H (eds). The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications. USA: Springer. | |
| Dr Orina Belton | |
| Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, (2008) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, (NA). | |
| Dr Oliver Blacque | |
| Blacque OE, Cevik S, Kaplan OI (2008) 'Intraflagellar transport: from molecular characterisation to mechanism'. Frontiers in Bioscience, 13 :2633-2652. | |
| Dr Derek P Brazil | |
| Murphy M, Crean JK, Brazil DP, Sadlier D, Martin F and Godson C (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochem J, 36 :941-945. | |
| Walsh DW*, Roxburgh SA*, Gettigan P, Berthier CC, Higgins D, Kretzler M, Cohen CD, Mezzano S, Brazil DP and Martin F (2008) 'Co-regulation of Gremlin and Notch signalling in diabetic nephropathy'. Biochimica Et Biophysica Acta, 1782 :10-12. | |
| Yang KJ, Shin S, Piao L, Shin E, Li Y, Park KA, Byun HS, Won M, Hong J, Kweon GR, Hur GM, Seok JH, Chun T, Brazil DP, Hemmings BA, Park J (2008) 'Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.'. JOURNAL OF BIOLOGICAL CHEMISTRY, 283 :1480-1491. | |
| Professor Geraldine Butler | |
| Butler G, Fitzpatrick DA, Logue ME, (2008) 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'. BMC Evolutionary Biology, 8 (1). | |
| Roetzer A, Gregori C, Jennings AM, Quintin J, Ferrandon D, Butler G, Kuchler K, Ammerer G, Schüller C. (2008) 'Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors'. Molecular Microbiology, 69 :603-620. | |
| Dr Patrick Caffrey | |
| Lara Soler, Patrick Caffrey, Hilary McMahon (2008) 'Effects of new amphotericin analogues on the scrapie isoform of the prion protein'. Biochimica et biophysica acta, 1780 :1162-1167. | |
| Caffrey, P., Aparicio, J. F., Malpartida, F., Zotchev, S. B. (2008) 'Biosynthetic engineering of polyene macrolides for generation of improved antifungal and antiparasitic agents'. Current Topics in Medicinal Chemistry, 8 (8):639-653. | |
| Power, P., Dunne, T., Murphy, B., Nic Lochlainn, L., Rai, D., Borissow, C., Rawlings, B., and Caffrey, P. (2008) 'Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics'. Chemistry & Biology, 15 :78-86. | |
| Dr Ben Clark | |
| Simmons TL, Coates RC, Clark BR, Engene N, Gonzalez D, Esquenazi E, Dorrestein PC, Gerwick WH (2008) 'Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages'. Proceedings of the National Academy of Sciences of the United States of America, 105 (12):4587-4594. | |
| Professor Paul Engel | |
| Muaawia Hamza, Paul C. Engel (2008) ''Homotropic allosteric control in clostridial glutamate dehydrogenase: different mechanisms for glutamate and NAD+ ?''. FEBS LETTERS, 582 :1816-1820. | |
| Michael A Sharkey and Paul C Engel (2008) 'Apparent negative cooperativity and substrate inhibition in overexpressed glutamate dehydrogenase from Escherichia coli'. FEMS Microbiol Letters, 281 :132-139. | |
| Yuxiang Huang, Mei Yee Choi, Shannon Wing Ngor Au, Deborah Man Yee Au, Veronica Min Sien Lam, Paul C Engel. (2008) 'Defective protein folding, a mechanism underlying two clinically different human glucose 6-phosphate dehydrogenase variants, G6PDPlymouth and G6PDMahidol '. Molecular Genetics and Metabolism . | |
| Carrigan JB and Engel PC (2007) ''Probing the determinants of coenzyme specificity in Peptostreptococcus asaccharolyticus glutamate dehydrogenase by site-directed mutagenesis''. FEBS JOURNAL, 274 :5167-5174. | |
| Hamza MA, Martin SR, Engel PC (2007) ''The contribution of tryptophan residues to conformational changes in clostridial glutamate dehydrogenase - W64 and W449 as mediators of the cooperative reponse to glutamate''. FEBS JOURNAL, 274 :4126-4134. | |
| Hamza MA, Engel, PC (2007) ''Enhancing long-term stability in mesophilic glutamate dehydrogenase from Clostridium symbiosum by eliminating cysteine residues''. Enzyme and Microbial Technology, 41 :706-710. | |
| Dr Neil Ferguson | |
Sharpe, T.D., Ferguson, N.,
Johnson, C. M. & Fersht, A.R. (2008) 'Conservation of Transition State
Structure in Fast Folding Peripheral Subunit Binding Domains'. Journal
of Molecular Biology, 383 :224-237.  |
|
| Dr David Fitzpatrick | |
| Butler G, Fitzpatrick DA, Logue ME, (2008) 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'. BMC Evolutionary Biology, 8 . | |
| Professor William Gallagher | |
| Brennan, D. J., Gallagher, W. M., (2008) 'Prognostic ability of a panel of immunohistochemistry markers - retailoring of an 'old solution''. Breast Cancer Research, 10 (102):1-3. | |
| Mulrane, L., Rexhepaj, E., Smart, V., Callanan, J. J., Orhan, D., Eldem, T., Mally, A., Schroeder, S., Meyer, K., Wendt, M., O'Shea, D., Gallagher, W. M., (2008) 'Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: An initial report from the PredTox group'. Experimental and Toxicologic Pathology, 60 (4-5):235-245. | |
| Gallagher WM, Brennan DJ, Rexhepaj E, O'Brien SL, McSherry E, O'Connor DP, Fagan A, Culhane AC, Higgins DG, Jirstrom K, Millikan RC, Landberg G, Duffy MJ, Hewitt SM, (2008) 'Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer'. CLIN CANCER RES, 9 (NA):2681-2689. | |
| Whelan LC, Power KA, McDowell DT, Kennedy PJ, Gallagher WM. (2008) 'Applications Of Seldi Technology In Oncology'. Journal of cellular and molecular medicine, (NA). | |
| Gallagher WM, Duffy MJ, McGowan PM, (2008) 'Cancer invasion and metastasis: changing views'. The Journal of pathology, 3 (NA):283-293. | |
| Dervan PA, Mc Sherry EA, Mc Goldrick A, Kay EW, Hopkins AM, Gallagher WM, (2007) 'Formalin-fixed paraffin-embedded clinical tissues show spurious copy number changes in array-CGH profiles'. Clinical genetics, 5 (NA):441-447. | |
| Pennington SR, Collins BC, Clarke A, Kitteringham NR, Gallagher WM, (2007) 'Use of proteomics for the discovery of early markers of drug toxicity'. Expert opinion on drug metabolism & toxicology, 5 (NA):689-704. | |
| Dr Jana Haase | |
| Malynn, S., Corbett, D., Campos-Torres, A., Haase, J., (2008) 'Pro-Inflammatory cytokines IL-1 beta anti TNF-alpha regulate the expression of the Serotonin transporter gene and interacting protein genes in vitro'. Journal of Neuroimmunology, 197 (2):169-169. | |
| Dr Caroline Herron | |
| Da Silva, N., Herron, C. E., Stevens, K., Jollimore, C. A. B., Barnes, S., Kelly, M. E. M., (2008) 'Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Muller cells'. Investigative Ophthalmology &Amp; Visual Science, 49 (7):3065-3073. | |
| Welzel, A. T., Smith, I. M., Herron, C., Selkoe, D. J., Walsh, D. M., (2008) 'Purification of distinct assembly forms of cell-derived Alzheimer amyloid-beta protein'. Journal of Neuroimmunology, 197 (2):164-164. | |
| Schmid AW, Freir, DB & Herron CE (2008) 'Schmid, A.W., Freir, D.B and Herron, C.E (2008) Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states. Brain Res 1197, 135-42'. BRAIN RESEARCH, 1197 :135-42. | |
| Minogue A, Lynch A, Loane D, Herron C and Lynch M. (2007) ' Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid'. JOURNAL OF NEUROCHEMISTRY, 103 :914-926. | |
| Dr Chandralal Hewage | |
| Subasinghage, A. R., Conlon, J. M., Hewage, C. M., (2008) 'Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: Identification of a full length helix-turn-helix motif'. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1784 (6):924-929. | |
| Cosgrove S, Rogers L, Hewage CM, Malthouse JP. (2007) 'NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases'. Biochemistry, 46 (39):11205-11215. | |
| Brennan L, Scullion SM, Mion B, Hewage C, Malthouse JG, Flatt PR, Newsholme P, McClenaghan NH. (2007) 'Prolonged alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta cells'. Diabetologia, 50 (1):0509-0509. | |
| Hewage CM, Alana I, O'Harte FPM (2007) 'Structural studies of glucose-dependent insulinotropic polypeptide (GIP) in micellular media'. Diabetologia, 50 (1):0593-0593. | |
| Dr Breandán Kennedy | |
| Kennedy BN, Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC, (2008) 'DUPLICATION AND DIVERGENCE OF ZEBRAFISH CRALBP GENES UNCOVERS A NOVEL ROLE FOR RPE- AND MUELLER-CRALBP IN CONE VISION'. Invest Ophthalmol Vis Sci . | |
| Smyth VA, Di Lorenzo D, Kennedy BN. (2008) 'A novel, evolutionary conserved enhancer of cone photoreceptor-specific expression.'. JOURNAL OF BIOLOGICAL CHEMISTRY . | |
| Alvarez Y, Cederlund ML, Cottell DC, Bill BR, Ekker SC, Torres-Vazquez J, Weinstein BM, Hyde DR, Vihtelic TS, Kennedy BN (2007) 'Genetic determinants of hyaloid and retinal vasculature in zebrafish'. BMC Evolutionary Biology, 7 (1). | |
| Professor Therese Kinsella | |
| Martina B. O'Keeffe, Helen M. Reid & B. Therese Kinsella. (2008) ' Agonist-dependent Internalization and Trafficking of the human Prostacyclin Receptor A Direct Role for Rab5a GTPase'. Biochima Et Biophysica Acta - Molecular Cell Research, 1783 :1914-1928. | |
| . AnneMarie M.Gannon & B. Therese Kinsella (2008) 'Regulation of the Human Thromboxane A2 Receptor Gene by Sp1, Egr1, NF-E2, GATA-1 and Ets-1 in Megakaryocytes'. Journal of Lipid Research, 48 ((12)):2590-2604. | |
| Katarina Wikström, Helen M. Reid, Maria Hill, Karol. A. English, Martina B. O¿Keeffe, Cisca C. Kimbembe & B. Therese Kinsella (2008) ' Recycling of the human prostacyclinreceptor is Regulated through a Direct interaction with RAB11a GTPase'. Cellular Signalling, 20 (12):2332-2346. | |
| . Katarina E. Wikström, David J. Kavanagh, Helen M. Reid & B.Therese Kinsella. (2008) ' Differential Regulation of RhoA-mediated Signaling by the TPa and TPb isoforms of the human Thromboxane A2 Receptor: Independent modulation of TPa signaling by Prostacyclin and Nitric Oxide. '. Cellular Signalling, 20 (8):1497-512. | |
| Dr Patricia Maguire | |
| Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., (2008) 'A proteomic approach to immune-mediated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. | |
| Behan AT, Foy M, Wynne K, Clarke M, Sullivan M, Cotter DR, Maguire PB (2007) 'Analysis of membrane microdomains-associated proteins in the insular cortex of human brain'. Proteomics Clinical Applications, 1 :1324-1331. | |
| Kerrigan SW, Jakubovics NS, Keane C, Maguire P, Wynne K, Jenkinson HF, Cox D. (2007) 'Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function'. Infection and Immunity, 75 (12):5740-5747. | |
| Professor Jonathan Malthouse | |
| Brennan L, McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JP, Flatt PR, Newsholme P, (2008) 'Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta-cells'. Clinical science (London, England : 1979), (NA). | |
| Cosgrove S, Rogers L, Hewage CM, Malthouse JP. (2007) 'NMR study of the inhibition of pepsin by glyoxal inhibitors: mechanism of tetrahedral intermediate stabilization by the aspartyl proteases'. BIOCHEMISTRY, 46 (39):11205-11215. | |
| Spink, E., Hewage, C.M. and Malthouse, J.P.G. (2007) 'Determination of the structure of tetrahedral transition state analogues bound at the active site of chymotrypsin using 18O and 2H isotope shifts in the 13C-NMR spectra of glyoxal inhibitors'. Biochemistry, 46 :12868-12874. | |
| Professor Finian Martin | |
| Gallagher WM, Lanigan F, O'Connor D, Martin F, (2007) 'Molecular links between mammary gland development and breast cancer'. Life Sciences, 64 (24):3159-3184. | |
| Martin F, McBryan J, Howlin J, Kenny PA, Shioda T, (2007) 'ERalpha-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis'. Oncogene, 26 (44):6406-6419. | |
| Dr Gethin McBean | |
| Vines, A., McBean, G., (2008) 'Calcium-mediated regulation of glutamate uptake in rat primary astrocytes'. Journal of Neuroimmunology, 197 (2):169-169. | |
| Kandil, S., Brennan, L., McBean, G., (2008) 'Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells'. Journal of Neuroimmunology, 197 (2):169-169. | |
| Manthacs, S., McBean, G., (2008) 'The cystine-glutamate exchanger in 1321N1 astrocytoma cells'. Journal of Neuroimmunology, 197 (2):168-168. | |
| McBean GJ, Montgomery T, Buon C, Eibauer S, Guiry PJ, Keenan AK, (2007) 'Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines'. British journal of pharmacology, 7 (NA):1121-1130. | |
| Dr Hilary McMahon | |
| Soler L., Caffrey P. and McMahon H.E.M. (2008) 'Effects of new amphotericin analogues on the scrapie isoform of the prion protein'. Biochimica Et Biophysica Acta . | |
| Prior, M., Lehmann, S., Sy, MS., Molloy, B., McMahon, H.E. (2007) 'Cyclodextrins inhibit replication of scrapie prion protein in cell culture'. Journal of Virology, 81 (20):11195-11207. | |
| Dr Tara McMorrow | |
| Slattery, C., Ryan, M. P., McMorrow, T., (2008) 'Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells'. International Journal of Biochemistry & Cell Biology, 40 (10):2218-2229. | |
| Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., (2008) 'A proteomic approach to immune-madiated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. | |
| Bennett, J., Ryan, M.P. and McMorrow, T. (2007) 'Diiferential effects of Immunosuppressive agents in human renal proximal tubular cells'. Journal of the American Society of Nephrology, 18 (400A). | |
| Feighery, R., Ryan, M.P. and McMorrow, T. (2007) 'Proteomic Approaches to Immune-Mediated Epithelial Mesenchymal Transition (EMT) in Renal Disease. '. Journal of the American Society of Nephrology, 18 (373A). | |
| Professor Wim Meijer | |
| Letek, M. Ocampo-Sosa, A.,
Sanders, M., Fogarty, U., Buckley, T., Leadon, D., Gonzalez, P., Scortii,
M., Meijer, W.G., Parkhill, J., Bentley, S., Vazquez-Boland, J.A. (2008)
'Evolution of the Rhodococcus equi vap pathogenicity island seen
through comparison of host associated vapA and vapB
virulence plasmids'. Journal of Bacteriology, 190
(17):5797-5805. |
|
| Wilson, B., B.S. Danilowicz
and W.G. Meijer (2008) 'The diversity of bacterial communities associated
with Atlantic cod Gadus morhua'. Microbial Ecology, 55
(3):425-434. |
|
| Byrne, G.A., C.A. Boland, E.P.
O'Connell and W.G. Meijer (2008) 'Differential mRNA stability of the
vapAICD operon of the facultative intracellular pathogen
Rhodococcus equi'. Fems Microbiology Letters, 280
(1):89-94. |
|
| Miranda-CasoLuengo, R.,
Prescott, J.F., Vazquez-Boland, J.A., Meijer, W.G. (2008) 'The
intracellular pathogen Rhodococcus equi produces a catecholate siderophore
required for saprophytic growth'. JOURNAL OF BACTERIOLOGY, 190
(5):1631-1637. |
|
| Dr Cormac Declan Murphy | |
| Donnelly C and Murphy C (2007) 'Bacterial defluorination of 4-fluoroglutamic acid'. Applied Microbiology and Biotechnology, 77 :699-703. | |
| Professor Philip Newsholme | |
| O¿Gorman DJ, Yousif O, Dixon G, McQuaid S, Murphy E, Rahman Y, Gasparro D, Pacini G, Newsholme P, Nolan JJ (2008) 'In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: a distinct sub-phenotype'. Diabetes Research and Clinical Practice, 80 (3):365-370. | |
| Newsholme P, Bender K, Kiely A, and Brennan (2007) 'Amino acid metabolism, insulin secretion and diabetes'. BIOCHEMICAL SOCIETY TRANSACTIONS, 35 :1180-1186. | |
| Dr Jens Erik Nielsen | |
| Sondergaard, C. R., McIntosh, L. P., Pollastri, G., Nielsen, J. E., (2008) 'Determination of electrostatic interaction energies and protonation state populations in enzyme active sites'. Journal of Molecular Biology, 376 (1):269-287. | |
| Søndergaard CR, McIntosh LP,
Pollastri G, Nielsen JE (2008) 'Determination of electrostatic interaction
energies and protonation state populations in enzyme active sites'.
Journal of Molecular Biology, 376 (1):269-287. |
|
| Dr Jasmina Nikodinovic | |
| Nikodinovic, J., Pereira, T., Nakazono, C., Dennis, G. R., Barrow, K. D. & Chuck, J.-A. (2008) 'Community structure and antibiotic production of Streptomyces nodosus bioreactors cultured in liquid environments'. Microbial Biotechnology, 1 (5):373-381. | |
| Martin, L. B., Nikodinovic, J., Mc Mahon, A. M., Vijgenboom, E. & O'Connor, K. E. (2008) 'Assessing the catalytic activity of three different sources of tyrosinase: A study of the oxidation of mono- and difluorinated monophenols'. Enzyme and Microbial Technology, 43 :297-301. | |
| Dr Kathy O'Boyle | |
| Murphy PV, Zhao Y, Zhou Y, O'Boyle KM, (2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'. Bioorganic & medicinal chemistry, 16 (12):6333-6337. | |
| Zhou, Y., Zhao, Y., O¿Boyle K.M., Murphu, P.V. (2008) 'Hybrid angioenesis inhibitors: synthesis and biological evaluation of bifunctionl cokmpounds based on 1-deoxynojirmycin and aryl-1,2,3-triazole.'. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS . | |
| Hogan N, O'Boyle KM, Hinkle PM, Kelly JA. (2008) 'A novel TRH analog, Glp-Asn-Pro-d-Tyr-d-TrpNH(2), binds to [(3)H][3-Me-His(2)]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2'. NEUROSCIENCE LETTERS . | |
| O'Connor JJ, O'Neill C, Nolan BJ, Macari A, O'Boyle KM, (2007) 'Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors'. European Journal of Neuroscience, 26 (12):3421-3428. | |
| Dr Darran O'Connor | |
| Lanigan F, O'Connor DP, Martin F, Gallagher WM (2007) 'Molecular links between mammary gland development and breast cancer'. Life Sciences . | |
| Dr John O'Connor | |
| Pickering M., Pickering, B.W., Murphy K.J., O¿Connor J.J. (2008) 'Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunohistochemical labelling'. Journal of Neuroscience Methods, 173 (1):27-33. | |
| 6 Fanning R.A., Campion D.P., Collins C.B., Keely S., Briggs L.P., O¿Connor J.J. and Carey M.F (2008) 'The effects of bupivacaine and levobupivacaine on isolated human pregnant myometrial contractility'. ANESTHESIA AND ANALGESIA, 107 (4):1303-1307. | |
| Dr Kevin O'Connor | |
| O'Connor KE, Nikodinovic J, Kenny ST, Babu RP, Woods T, Blau WJ, (2008) 'The conversion of BTEX compounds by single and defined mixed cultures to medium-chain-length polyhydroxyalkanoate'. Applied microbiology and biotechnology, 4 (NA):665-673. | |
| Martin, L. B., Nikodinovic, J., Mc Mahon, A. M., Vijgenboom, E. & O'Connor, K. E. (2008) 'Assessing the catalytic activity of three different sources of tyrosinase: A study of the oxidation of mono- and difluorinated monophenols'. Enzyme and Microbial Technology, 43 :297-301. | |
| Dr James O'Gara | |
| Stevens, N., Tharmabala, M., Dillane, T., Greene, C., O'Gara, J. P., Humphreys, H. (2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'. Clinical Microbiology and Infection, 14 :719-722. | |
| Holland, L. M., O'Donnell, S. T., Ryjenkov, D.A., Gomelsky, L., Slater, S.R., Fey, P.D., Gomelsky, M. and O'Gara, J.P. (2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of c-di-GMP'. Journal of Bacteriology, 190 :5178-5189. | |
| O'Neill, E., Pozzi, C., Houston, P., Humphreys, H., Robinson, D.A., Loughman, A., Foster, T.J. and O'Gara J.P. (2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'. Journal of Bacteriology, 190 (11):3835-3850. | |
| Professor Ciaran Regan | |
| ter Horst, J. P. F., Loscher, J. S., Pickering, M., Regan, C. M., Murphy, K. J., (2008) 'Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific'. European Journal of Neuroscience, 28 (3):419-427. | |
| Shankar, G. M., Li, S. M., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., Selkoe, D. J., (2008) 'Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory'. Nature Medicine, 14 (8):837-842. | |
| Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Hunter AJ, Walsh FS, Regan CM (2008) 'The selective 5-HT(6) receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats'. Neuropharmacology, 54 (8):1166-1174. | |
| Dr Helen Reid | |
| Wikstrom, K.,Kavanagh, D.
J.,Reid, H. M.,Kinsella, B. T. (2008) 'Differential regulation of
RhoA-mediated signaling by the TP alpha and TP beta isoforms of the human
thromboxane A2 receptor: Independent modulation of TP alpha signaling by
prostacyclin and nitric oxide'. Cellular Signalling, 20
(8):1497-1512. |
|
| Dr Dominic Walsh | |
| Irvine, G. B., El-Agnaf, O. M., Shankar, G. M., Walsh, D. M., (2008) 'Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases'. Molecular Medicine, 14 (7-8):451-464. | |
| Shankar, G. M., Li, S. M., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., Selkoe, D. J., (2008) 'Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory'. Nature, 14 (8):837-842. | |
| Welzel, A. T., Smith, I. M., Herron, C., Selkoe, D. J., Walsh, D. M., (2008) 'Purification of distinct assembly forms of cell-derived Alzheimer amyloid-beta protein'. Immunology, 197 (2):164-164. | |
| Frigerio, C. S., Kukar, T., Osenkowski, P., Wolfe, M. S., Golde, T., Engel, P. C., Walsh, D. M., (2008) 'Selective modulation of the gamma cleavage of Alzheimer's disease amyloid precursor proteins'. Immunology, 197 (2):165-165. | |
| Dr Xiao-Tao Wang | |
| Wang, X. T.,Chan, T. F.,Lam,
V. M. S.,Engel, P. C. (2008) 'What is the role of the second "structural"
NADP(+)-binding site in human glucose 6-phosphate dehydrogenase?'.
Protein Science, 17 (8):1403-1411. |
|
| Dr Tadhg Ó'Cróinín | |
| O Croinin T and Dorman C.J. (2007) 'Expression of the Fis protein is sustained in late-exponential- and stationary-phase cultures of Salmonella enterica serovar Typhimurium grown in the absence of aeration'. MOLECULAR MICROBIOLOGY, 66 (1):237-251. | |
| Dr Orina Belton | |
| Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, (2008) Atherosclerosis Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse, | |
| Dr Antonio Campos Torres | |
| J. Martin, A. Campos-Torres (2008) Complement Anaphylatoxin C5a alters D-[3H]aspartate uptake by Na+-dependent glutamate transporter EAAC1 in rat C6 Glioma cells International Neuroimmunology Symposium, Marie Curie Molecular Neuroimmunology Programme, University College Dublin, Journal of Neuroimmunology, 197:2(159-176), | |
| Campos-Torres A. (2008) Building a link between innate immunity and post-lesional neuron-glia plasticity in the CNS International Neuroimmunology Symposium, Marie Curie Molecular Neuroimmunology Programme, University College Dublin, Journal of Neuroimmunology, 197:2(159-176), | |
| Dr Jana Haase | |
| Corbett D, Campos-Torres A, Haase J (2008) THE EFFECTS OF PRO-INFLAMMATORY CYTOKINES ON THE SEROTONIN TRANSPORTER AND INTERACTING PROTEINS IN A NEURONAL CELL LINE Neuroscience Ireland Conference, Galway, | |
| Dr Patricia Maguire | |
| Atzei, P., Maguire, P. B., Kennedy, B. N., Moynagh, P. N., (2008) Journal of Neuroimmunology Cactin, a novel regulator of TLR signalling pathways, 162 - 162 | |
| Dr Tara McMorrow | |
| Bennett, J., Ryan, M.P. and McMorrow, T. (2007) Diiferential effects of Immunosuppressive agents in human renal proximal tubular cells . In: J.Am. Soc. Nephrol eds. American Society of Nephrology, 400A | |
| Feighery, R., Ryan, M.P. and McMorrow, T. (2007) Proteomic Approaches to Immune-Mediated Epithelial Mesenchymal Transition (EMT) in Renal Disease . In: J. Am. Soc. Nephrol eds. American Society of Nephrology, 373A | |
| Professor Wim Meijer | |
| Finn, C.E., X. Chen & W.G. Meijer. (2007) 160th Meeting of the Society for General Microbiology P MI 34 Protein networks of Rhodococcus equi, | |
| Miranda-CasoLuengo, R. and W.G. Meijer. (2007) 160th Meeting of the Society for General Microbiology, Manchester. p CCS 09 Iron acquisition by Rhodococcus equi, | |
| Dr Cormac Declan Murphy | |
| BR Clark, S Tennant, JH Gill, E Lacey, RJ Capon and CD Murphy (2008) Pyrrolylpolyenes from fungi: biosynthesis and analogue production . In: Leandros Skaltsounis, Prokopios Magiatis eds. 7th Joint Meeting of GA, AFERP, ASP, PSE and SIF, Athens, Greece, | |
| Dr Kathy O'Boyle | |
| Nolan, B., O¿Boyle K.M. (2007)
The effects of caffeine on adenosine and dopamine receptor density in rat
striatum British Pharmacological Society
, |
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| Downey C, O¿Boyle K.M. (2007)
Effects of MDMA and caffeine on renal cells and drug metabolising enzymes
British Pharmacological Society, |
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| Dr John O'Connor | |
| Watters O., O¿Connor J.J., Sheridan G.K., Murphy K.J. & Pickering M. (2008) Modulation of glutamate excitotoxicity and ischemic pre-conditioning by TNFα depends on time and order of TNFα and glutamate exposure J. Neuroimmunology, Vol. 197, page 171, | |
| Sheridan, G. K., Pickering, M., Moynagh, P. N., O'Connor, J. J., Murphy, K. J. (2007) Temporal changes in nuclear factor-kappa B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience, 207.5 | |
| O¿Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M. (2007) Modulation of glutamate excitotoxicity and ischemic preconditioning by TNFα depends on time and order of TNFα and glutamate exposure Society for Neuroscience, | |
| Dr Dominic Walsh | |
| Kukar, T. L., Ladd, T. B., Bann, M. A., Fraering, P. C., Narlawar, R., Maharvi, G. M., Healy, B., Chapman, R., Welzel, A. T., Price, R. W., Moore, B., Rangachari, V., Cusack, B., Eriksen, J., Jansen-West, K., Verbeeck, C., Yager, D., Eckman, C., Ye, W. J., Sagi, S., Cottrell, B. A., Torpey, J., Rosenberry, T. L., Fauq, A., Wolfe, M. S., Schmidt, B., Walsh, D. M., Koo, E. H., Golde, T. E., (2008) Nature Substrate-targeting gamma-secretase modulators, 925 - 62 | |
| Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., Selkoe, D. J., Anwyl, R., Walsh, D. M., Rowan, M. J., (2008) Journal of Neuroscience Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: Prevention by systemic passive immunization, 4231 - 4237 | |
| Martin F, Walsh DW, Roxburgh SA, McGettigan P, Berthier CC, Higgins DG, Kretzler M, Cohen CD, Mezzano S, Brazil DP, (2008) Biochimica et biophysica acta Co-regulation of Gremlin and Notch signalling in diabetic nephropathy, 10 - 21 | |
| Martin F, Walsh DW, Roxburgh SA, McGettigan P, Berthier CC, Higgins DG, Kretzler M, Cohen CD, Mezzano S, Brazil DP, (2008) Biochimica et biophysica acta Co-regulation of Gremlin and Notch signalling in diabetic nephropathy, 10 - 21 | |
