'Hippocampus neurons'. Image by Kate Harris.
UCD School of Biomolecular & Biomedical Science - Research Publications 2008/09
Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2008/09
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| Dr Patrick Caffrey | |
| Zotchev, S. B., Caffrey, P. (2009) 'Genetic analysis of nystatin and amphotericin biosynthesis' In: Hopwood, D. A (eds). Methods in Enzymology Volume 459, Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. USA: Elsevier. | |
| Dr Tara McMorrow | |
| McMorrow T., Campbell E., Slattery C., Ryan M.P. (2008) 'Altered gene expression and molecular Mechanisms modulating epithelial-mesenchymal transition in human renal epithelial cells' In: Paul J Higgins (eds). Human Epithelial Tumor Cell Plasticity: Implications for Cancer Progression and Metastasis. India: Research Signpost. | |
| Dr Jens Erik Nielsen | |
Nielsen JE (2009) 'Analyzing Enzymatic pH ActivityProfiles and Protein TitrationCurves Using Structure-Based pKaCalculations and TitrationCurve Fitting' In: Michael L. Johnson and Ludwig Brand (eds). Methods in Enzymology, Volume 454. Elsevier.  |
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| Nielsen JE (2008) 'Analyzing Protein NMR pH-Titration Curves' In: A. Wheeler and David C. Spellmeyer (eds). Annual Reports in Computational Chemistry, Volume 4. Amsterdam: Elsevier. | |
| Professor Steffen Backert | |
| Sason, H., Milgrom, M., Weiss, A.M., Melamed-Book, N., Balla, T., Grinstein, S., Backert, S., Rosenshine, I., Aroeti, B. (2009) 'Enteropathogenic Escherichia coli0 subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection'. Molecular Biology of the Cell, 20 :544-555. | |
| Dr Orina Belton | |
| Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, (2009) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, 202 (1):84-91. | |
| Dr Oliver Blacque | |
| Bialas NJ, Inglis PN, Li C, Robinson JF, Parker JD, Healey MP, Davis EE, Inglis CD, Toivonen T, Cottell DC, Blacque OE, Quarmby LM, Katsanis N, Leroux MR. (2009) 'Functional interactions between the ciliopathy-associated Meckel syndrome 1(MKS1) protein and two novel MKS1-related (MKSR) proteins'. Journal of Cell Science, 122 (5):611-624. | |
| Professor Geraldine Butler | |
| Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M,Cuomo CA. (2009) 'Evolution of pathogenicity and sexual reproduction in eight Candida genomes'. Nature, 459 :657-662. | |
| Dr Patrick Caffrey | |
| Laura Nic Lochlainn, Patrick Caffrey (2009) 'Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering'. Metabolic Engineering, 11 :40-47. | |
| Dr John Crean | |
| Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society transactions, Pt 5 (NA):941-945. | |
| Dr Neil Ferguson | |
| Neuweiler, H., Sharpe, T. D., Rutherford, T. J., Johnson, C. M., Allen, M. D., Ferguson, N. & Fersht, A. R. (2009) 'The folding mechanism of BBL: Plasticity of transition state structure observed within an ultrafast folding protein family'. Journal of Molecular Biology, 390 :1060-1073. | |
| Neuweiler, H., Sharpe, T. D., Johnson, C. M., Teufel, D. P., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier limited folding of BBL. 2. Mechanistic Insights from kinetics of folding monitored by independent tryptophan probes'. Journal of Molecular Biology, 387 :975-985. | |
| Arbely, A., Rutherford, T. J., Sharpe, T. D., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier-limited folding. 1. Energetic and structural basis for the perturbation of the protein BBL on protonation of a histidine of unusually low pKa'. Journal of Molecular Biology, 387 :986-992. | |
| Professor William Gallagher | |
| Borrebaeck CA, Brennan DJ, Ek S, Doyle E, Drew T, Foley M, Flannelly G, O'Connor DP, Gallagher WM, Kilpinen S, Kallioniemi OP, Jirstrom K, O'Herlihy C, (2009) 'The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer'. EUROPEAN JOURNAL OF CANCER, 45 (8):1510-1517. | |
| Gallagher WM, Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, Jirstrom K, Landberg G, Martin F, Duffy MJ, (2009) 'Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer'. International Journal of Cancer, 9 (NA):2088-2097. | |
| Ponten F, Strömberg S, Agnarsdóttir M, Magnusson K, Rexhepaj E, Bolander A, Lundberg E, Asplund A, Ryan D, Rafferty M, Gallagher WM, Uhlen M, Bergqvist M, (2009) 'Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma'. JOURNAL OF PROTEOME RESEARCH, 4 (NA):1639-1646. | |
| Koenig J, Gallagher WM, Tweats D, (2009) 'Omic profiling for drug safety assessment: current trends and public-private partnerships'. Drug Discovery Today, 14 (7-8):337-342. | |
| Gallagher WM, Gremel G, Rafferty M, Lau TY, (2009) 'Identification and functional validation of therapeutic targets for malignant melanoma'. Critical reviews in oncology/hematology, 72 (3):194-214. | |
| Gallagher WM, Mulrane L, Rexhepaj E, Penney S, Callanan JJ, (2008) 'Automated image analysis in histopathology: a valuable tool in medical diagnostics'. EXPERT REV MOL DIAGN, 6 (NA):707-725. | |
| Gallagher WM, Rexhepaj E, Brennan DJ, Holloway P, Kay E, McCann AH, Landberg G, Duffy MJ, Jirstrom K, (2008) 'Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of estrogen and progesterone receptor levels in breast cancer'. Breast cancer research : BCR, 10 (5). | |
| Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M (2008) 'A microRNA DNA methylation signature for human cancer metastasis'. PNAS, 105 (36):13556-13561. | |
| O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. | |
| Dr Caroline Herron | |
| Herron CE, Schmid AW, Lynch MA, (2008) 'The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo'. Hippocampus . | |
| Dr Chandralal Hewage | |
| Malthouse JP, Howe N, Rogers L, Hewage C, (2009) 'Oxyanion and Tetrahedral Intermediate Stabilization by subtilisin: Detection of a new tetrahedral adduct'. Biochimica et biophysica acta, 1794 (8):1251-1258. | |
| Professor Therese Kinsella | |
| Donnellan PD, Kinsella BT (2009) 'Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively'. Journal of Molecular Signaling, 25 . | |
| Elizabeth C. Turner & B. Therese Kinsella. (2009) 'Transcripional Regulation of the Human Prostacyclin Receptor Gene is dependent on Sp1, Pu.1 and Oct-1 in Megakaryocytes and Endothelial Cells'. Journal of Molecular Biology, 386 :579-597. | |
| Professor Jonathan Malthouse | |
| Malthouse JP, Howe N, Rogers L, Hewage C, (2009) 'Oxyanion and Tetrahedral Intermediate Stabilization by subtilisin: Detection of a new tetrahedral adduct'. Biochimica et biophysica acta, 1794 :1251-1258. | |
| Dr Gethin McBean | |
| Godson C, Decker Y, McBean G, (2009) 'Lipoxin A4 inhibits IL-1{beta}-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. American journal of physiology. Cell physiology, 296 (NA):C1420-C1427. | |
| McBean GJ, Murphy A, Vines A, (2009) 'Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx'. Biochimica et biophysica acta, 1788 :551-558. | |
| Dr Margaret McGee | |
| Bannon JH, Mc Gee MM. (2009) 'Understanding the role of aneuploidy in tumorigenesis'. BIOCHEMICAL SOCIETY TRANSACTIONS, 37 ((Pt 4):):910-913. | |
| Bane FT, Bannon JH, Pennington SR, Campiani G, Williams DC, Zisterer DM, Mc Gee MM, (2009) 'The microtubule-targeting agents, PBOX-6 and paclitaxel, induce nuclear-cytoplasmic redistribution of the peptidyl prolyl isomerases, cyclophilin A and pin1, in malignant haematopoietic cells'. Journal of Pharmacology and Experimental Therapeutics, 329 :38-47. | |
| Dr Tara McMorrow | |
| Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. | |
| O Riordan A., Johnston O., McMorrow T., Wynne K., Maguire P., Hegarty J.E., McCormick A., Watson A.J., Cagney G., Gallagher W.M. and Ryan M.P. (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (8):1338-1348. | |
| Nee L, O'Connell S, Nolan S, Ryan MP, McMorrow T, (2008) 'Nitric Oxide Involvement in TNF-alpha and IL-1beta-Mediated Changes in Human Mesangial Cell MMP-9 and TIMP-1'. Experimental Nephrology, 110 (2):1-1. | |
| Professor Wim Meijer | |
| Smith, C.J., B.S. Danilowicz, W.G. Meijer (2009) 'Bacteria associated with the mucus layer of Merlangius merlangus0 (whiting) as biological tags to determine harvest location'. Canadian Journal of Fisheries and Aquatic Science, 66 :713-716. | |
| Vazquez-Boland, J.A., Prescott, J.F., Meijer, W.G, Leadon DP, Hines, S.A. (2009) 'Rhodococcus equi comes of age'. Equine Veterinary Journal, 41 (1):93-95. | |
| Dr Cormac Declan Murphy | |
| Heffernan, H., Murphy, C. and Casey, E. (2009) 'Comparative performance of planktonic and biofilm cultures of Pseudomonas fluorescens DSM 8341 grown on fluoroacetate'. Applied and Environmental Microbiology, 75 :2899-2907. | |
| Donnelly, C. and Murphy C. (2009) 'Purification and properties of fluoroacetate dehalogenase from Pseudomonas fluorescens DSM8341'. Biotechnology Letters, 31 :245-250. |
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| Moran, S., Rai, D. Clark, B. and Murphy, C. (2009) 'Precursor-directed biosynthesis of fluorinated iturin A in Bacillus subtilis'. Organic and Biomolecular Chemistry, 7 :644-646. |
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| Clark BR and Murphy CD (2009) 'Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum'. Organic and Biomolecular Chemistry, 7 :111-116. |
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| Cobb, S.L. and Murphy, C.D. (2009) 'F-19 Applications in Chemical Biology'. Journal of Fluorine Chemistry, 130 :132-143. | |
| Murphy, C.D., Quirke, S. and Balogun, O (2008) 'Degradation of fluorobiphenyl by Pseudomonas pseudoalcaligenes KF707'. Fems Microbiology Letters, 286 :45-49. | |
| Dr Keith J Murphy | |
| Regan CM, Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, (2008) 'Curcumin-induced degradation of PKCdelta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats'. Biochemical Pharmacology, 77 (7):1254-1265. | |
| Regan CM, Seymour CM, Foley AG, Murphy KJ, (2008) 'Intraventricular infusions of anti-NCAM PSA impair the process of consolidation of both avoidance conditioning and spatial learning paradigms in Wistar rats'. Neuroscience, 157 (4):813-820. | |
| Professor Philip Newsholme | |
| McClenaghan NH, Scullion SM, Mion B, Hewage C, Malthouse JPG, Flatt PR, Newsholme P, Brennan L (2009) 'Prolonged L-alanine exposure induces changes in metabolism, Ca 2+ handling and desensitisation of insulin secretion in clonal pancreatic beta-cells'. CLINICAL SCIENCE, 116 :341-351. | |
| Vinolo MA, Hatanaka E, Lambertucci RH, Newsholme P, Curi R. (2009) 'Effect of short chain fatty acids on effector mechanisms of neutrophils'. CELL BIOCHEMISTRY AND FUNCTION, 27 (1):48-55. | |
| Keane D. and Newsholme P. (2008) 'Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells'. BIOCHEMICAL SOCIETY TRANSACTIONS, 36 :955-958. | |
| Dr Jens Erik Nielsen | |
| Nielsen JE, Søndergaard CR, Garrett AE, Carstensen T, Pollastri G, (2009) 'Structural Artifacts in Protein-Ligand X-ray Structures: Implications for the Development of Docking Scoring Functions'. Journal of medicinal chemistry, 52 (18):5674-5684. | |
| Lepperdinger G, Reitinger S, Müllegger J, Greiderer B, Nielsen JE, (2009) 'Designed human serum hyaluronidase 1 variant, HYAL1{Delta}L, exhibits activity up to pH 5.9'. Journal of Biological Chemistry, 284 (29):19173-19177. | |
| Dr Kathy O'Boyle | |
| O'Connor JJ, O'Neill C, Evers-Donnelly A, Nicholson D, O'Boyle KM, (2009) 'D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry'. Journal of Neurochemistry, 108 (3):545-551. | |
| Dr John O'Connor | |
| O'Neill C., Evers Donnelly, A., O'Boyle K.M. and O'Connor J.J. (2009) 'D2 receptor mediated inhibition of dopamine release from rat striatum is modulated by CB1 receptors: studies using fast cyclic voltammetry'. Journal of Neurochemistry, 108 (3):545-551. | |
| O'Connor JJ & O'Neill C (2008) 'A Role for Adenosine A1 Receptors in GABA and NMDAReceptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry'. Sensors, 8 :5229-5237. |
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| Dr Kevin O'Connor | |
| O'Connor KE, Goff M, Nikodinovic-Runic J, (2009) 'Characterization of temperature-sensitive and lipopolysaccharide overproducing transposon mutants of Pseudomonas putida CA-3 affected in PHA accumulation'. FEMS MICROBIOL LETT, 2 (NA):297-305. | |
| O'Connor KE, Kenny ST, Runic JN, Kaminsky W, Woods T, Babu RP, Keely CM, Blau W, (2008) 'Up-cycling of PET (polyethylene terephthalate) to the biodegradable plastic PHA (polyhydroxyalkanoate)'. Environmental Science &Amp; Technology, 42 (20):7696-7701. | |
| O'Connor KE, Nikodinovic J, Kenny ST, Babu RP, Woods T, Blau WJ, (2008) 'The conversion of BTEX compounds by single and defined mixed cultures to medium-chain-length polyhydroxyalkanoate'. Applied microbiology and biotechnology, 4 (NA):665-673. | |
| Dr James O'Gara | |
| Glynn, A. A., S. T. O'Donnell, D. C. Molony, E. Sheehan, D. J. McCormack, and J. P. O'Gara. (2009) 'Hydrogen peroxide induced repression of icaADBC0 transcription and biofilm development in Staphylococcus epidermidis0'. Journal of Orthopaedic Research, 27 :627-630. | |
| O'Neill, E., Humphreys, H., and O'Gara, J.P. (2009) 'Carriage of both the fnbA0 and fnbB0 genes and growth at 37oC promotes FnBP-mediated biofilm development in MRSA clinical isolates'. Journal of Medical Microbiology, 58 :399-402. | |
| Stevens, N. T., Sadovskaya, I., Jabbouri, S., Sattar, T., O'Gara, J. P., Humphreys, H. and C. M. Greene (2009) 'Staphylococcus epidermidis Polysaccharide Intercellular Adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'. Cellular Microbiology, 11 :421-432. | |
| Cotter, J.J., O'Gara, J. P., Mack, D. and E. Casey (2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor σB in Staphylococcus epidermidis'. Applied and Environmental Microbiology, 75 :261-264. | |
| Professor Ciaran Regan | |
| Regan CM, Seymour CM, Foley AG, Murphy KJ, (2008) 'Intraventricular infusions of anti-NCAM PSA impair the process of consolidation of both avoidance conditioning and spatial learning paradigms in Wistar rats'. Neuroscience, 4 (NA):813-820. | |
| Regan CM, Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, (2008) 'Curcumin-induced degradation of PKCdelta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats'. BIOCHEM PHARMACOL, 77 (7):1254-1265. | |
| Professor Dominic Walsh | |
| Walsh DM, Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, (2009) 'Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life'. Neurobiology of Disease, 36 (2):293-302. | |
| Selkoe D, Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, (2009) 'Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake'. Neuron, 62 (6):788-801. | |
| Walsh DM, Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, (2009) 'gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons'. Brain Research, 1262 :89-99. | |
| Sean D. O¿Shea, Imelda M. Smith, Olive M. McCabe, Michelle M. Cronin, Dominic M. Walsh and William T. O¿Connor (2008) 'Intracerebroventricular administration of amyloid b-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat.0'. Sensors, 8 :7428-7437. | |
| Linse S, Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindman S, Minogue AM, Thulin E, Walsh DM, Dawson KA, (2008) 'Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles'. Journal of the American Chemical Society, 130 (46):15437-15443. | |
| Neng-Wei Hu, Imelda M. Smith, Dominic M. Walsh and Michael J. Rowan (2008) 'Soluble amyloid-ß peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo'. Brain, 131 :2414-2424. | |
| Walsh DM, Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, (2008) 'Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin'. Neurobiology of Disease, 31 (3):442-450. | |
| Dr John Crean | |
| Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, (2008) Biochemical Society transactions Regulation and consequences of differential gene expression in diabetic kidney disease, 941 - 945 | |
| Dr Jana Haase | |
| Malynn S, Grudzinska J. Campos-Torres A, Haase J. (2008) Stress and cytokine regulated neuronal membrane glycoprotein M6a interacts with and regulates the serotonin transporter (SERT) First Annual Symposium of SFB35 Transmembrane Transporters in Health and Disease, | |
| Dr Caroline Herron | |
| Metais C and Herron CE (2009) Effects of Chronic and Acute Simvastatin Treatment on Synaptic Transmission in Hippocampal Slices from C57Black 6J Mice Physiological Society, | |
| Professor Therese Kinsella | |
| T. Kinsella. (2008) Expression and intracellular signalling by the TPa and TPb isoforms of the human thromboxane A2 receptor Biochemical Society (IAS) Gold Medal Lecture, Presented that the Genome Instability and Cancer, Biochemical Society (IAS) Focused Meeting, National University of Ireland, Galway, Ireland, | |
| Helen M. Reid, Martina B. O¿Keeffe, Karol English & B. Therese Kinsella. (2008) Role of Rab5 in Agonist-Induced Internalization of the human Prostacyclin Receptor Moderated poster, presented at Conway Institute Annual Festival of Research, | |
| Katarina Wikström, David J. Kavanagh, Helen M. Reid & B. Therese Kinsella. (2008) Differential Regulation of RhoA-mediated Signaling by the TPa and TPb isoforms of the human Thromboxane A2 Receptor Conway Institute Annual Festival of Research, | |
| Dr Tara McMorrow | |
| Bennett J., Ryan M.P., McMorrow T. (2008) Molecular Mechanisms of Immunosuppressive Agents in Human Renal Proximal Tubular Cells American Society of Nephrology, | |
| Radford R., Ryan M.P., McMorrow T. (2008) Development of Renal Cell Culture Models of Carcinogenesis within the E.U. CarcinoGENOMICS Project: Analysis of Epithelial Mesenchymal Transition (EMT) Induction American Society of Nephrology, | |
| Martin N., Ryan G.E., McMorrow T., Ryan M.P. (2008) Molecular Mechanisms of Immunosuppressant-Induced Alteration of Barrier Function in Renal Proximal Tubular Cells American Society of Nephrology, | |
| Dr Cormac Declan Murphy | |
| Murphy C, (2008) Probing the interaction of fluorinated compounds and microorganisms using 19F NMR SMASH NMR Conference, Santa Fe NM, USA, | |
| Professor Philip Newsholme | |
| M. Salvucci, Z. Neufeld and P. Newsholme (2009) Developing a mathematical model of insulin release from pancreatic beta cells: The importance of glutamate Physiology 2009 Poster Communications, | |
| M. Krause, P.I. Homem de Bittencourt Jr and P. Newsholme (2009) The effect of IL-6 on insulin secretion, nitric oxide release, redox status and signal transduction in a clonal pancreatic beta cell line Physiology 2009 Oral Communications, | |
| M. Farrelly, C. Murphy and P. Newsholme (2009) Effects of Interleukin-6 on glucagons secretion and viability of the pancreatic alpha cell line (alpha-TC1-9) Physiology 2009 Poster Communications, | |
| N. Mullooly and P. Newsholme (2009) Effects of a glucokinase activator on glucolipotoxix and cytokine-induced beta cell dysfunction and cell integrity Physiology 2009 Oral Communications, | |
| R.E. Sumayao and P. Newsholme (2009) Effect of cstine dimethylester lysosomal loading on the viability of LLC-PK1 cells Physiology 2009 Poster Communications, | |
| Mullooly N, Newsholme P, Smith D (2008) Assessment of the AstraZeneca glucokinase activator GKA50 on pancreatic beta cell function and viability in the clonal beta cell line BRIN-BD11 The European Association for the Study of Diabetes 44th Annual meeting Rome, Rome Italy, S201 - S201 | |
| Kiely A and Newsholme P (2008) TLR agonist induced changes in BRIN-BD11 clonal beta cell metabolism, signal transduction and insulin secretion The European Association for the Study of Diabetes 44th Annual meeting Rome, Rome, Italy, S263 - S264 | |
| Kiely AM, Newsholme P (2008) TLR agonist induced changes in BRIN-BD11 clonal beta cell metabolism, signal transduction and insulin secretion The European Assocition for the Study of Diabetes 44th Annual meeting Rome, Rome Italy, S263 - S264 | |
| Dr Jens Erik Nielsen | |
| Predrag Kukić, Damien Farrell, Chresten Søndergaard, Una Bjarnadottir, John Bradley, Gianluca Pollastri , Jens Erik Nielsen (2009) Improving the analysis of NMR spectra tracking pH-induced conformational changes: Removing artefacts of the electric field on the NMR chemical shift Celebrate the 50th Anniversary of the Determination of the Structure of Myoglobin. VIII European Symposium of The Protein Society Zurich, Switzerland, June 14-18, 2009, | |
| Fergal O¿Meara, Chresten R. Søndergaard, Michael A. Johnston, Jens Erik Nielsen (2009) Using an Alanine Scan of Hen Egg White Lysozyme (HEWL) to Validate PEAT-SA Celebrate the 50th Anniversary of the Determination of the Structure of Myoglobin. VIII European Symposium of The Protein Society Zurich, Switzerland, June 14-18, 2009, | |
| Dr Kathy O'Boyle | |
| Ciaran Downey, Francesca Daly, Alan Kirwan, Kathy O¿Boyle (2009) Effects of MDMA and caffeine on serotonin uptake by rat whole brain synaptosomes British Pharmacological Society, Summer Meeting, 8-10 July, Edinburgh, |
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| Brian Nolan, Kathy O¿Boyle (2009) Interaction between 6-chloro PB and CCPA on [35S]GTPγS binding in rat striatum British Pharmacological Society, Summer Meeting, 8-10 July, Edinburgh, |
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| Dr John O'Connor | |
| Watters O., O¿Connor J.J. (2009) Effects of tumour necrosis factor-α and glutamate pretreatment on glutamate-induced calcium influx in rat organotypic hippocampal cultures Procedings of the Physiological Society, | |
| Batti L., Taylor C.T. & O¿Connor J.J. (2009) Modulation of synaptic transmission by TNF-α after hypoxic exposure in rat hippocampal slices Procedings of the Physiological Society, | |
| Reynolds A.L., O¿Connor J.J., Humphries P. (2008) Strain-specific differences in hippocampal neurotransmission in isolated C57BL/6JOlaHsd and 129S2/SvHsd mouse brain slices Irish journal of Medical Science, | |
| Watters, O., O¿Connor, J.J. (2008) A comparison of the timecourse of glutamate-induced calcium influx in rat organotypic hippocampal cultures using manual and image software analysis Irish journal of Medical Science, | |
| Batti, L., Taylor, C., Sheridan, G., O¿Connor, J.J. (2008) Hippocampal CA1 and granule cells respond differentially to mild hypoxia: roles for HIF-1α and NF-κB Irish journal of Medical Science, | |
| Batti, L., Taylor, C., O¿Connor, J.J. (2008) An investigation into the role of adenosine A1 receptors in hippocampal LTP after exposure to mild hypoxia Irish Journal of Medical Science, | |
| Dr Tadhg Ó'Cróinín | |
| N. Corcionivoschi, A. Alemka, M. Clyne, T. O¿Croinin, B. Bourke (2009) Host Derived Reactive Oxygen Species Modulate Bacterial Tyrosine Phosphorylation Pathway to Attenuate CPS Production in Campylobacter jejuni 81-176 during Infection of Human Epithelial Cells American Society of Microbiology : Annual General Meeting, | |
