'Fluorescent microscopy'. Image by Ms. Naheda Alkazemi.
UCD School of Biomolecular & Biomedical Science - Research Publications 2009/10
Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2009/10
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| Professor Paul C Engel | |
| Paul C. Engel (2009) Pain-free Biochemistry. Chichester: Wiley-Blackwell. | |
| Professor Geraldine Butler | |
| David A. Fitzpatrick and Geraldine Butler (2010) 'Comparative genomic analysis of pathogenic yeasts and the evolution of virulence' In: H. Ruth Asbee and Elanine M. Bignell (eds). The Yeast Handbook: Pathogenic Yeasts. Berlin: Springer. | |
| Professor Paul C Engel | |
| Engel, P.C and Paradisi, F. (2010) 'Novel enzymes for biotransformation and resolution of alpha-amino acids' In: J.C Vederas (eds). Comprehensive Natural Product 2 Chemistry and Biology. Oxford: Elsevier. | |
| Conway,P. and Paradisi, F. and Engel, P.C. (2010) 'Synthesis of substituted derivatives of L-phenylalanine and of other non-natural L-amino acids using engineered mutants of phenylalanine dehydrogenase' In: John Whittal & Peter W. Sutton (eds). Practical Methods in Biocatalysis and Biotransformations. Oxford: John Wiley. | |
| Dr Cormac Declan Murphy | |
Murphy, C.D. and Grant R. (2010) 'Chemicals production - biohalogenation' In: Timmis KN (eds). Handbook of hydrocarbon and lipid microbiology. Heidelberg: Springer. 
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Murphy, C. (2010) 'Halogenated Organic Compounds - Carbon-Halogen Bond Formation' In: Timmis KN (eds). Handbook of hydrocarbon and lipid microbiology. Heidelberg: Springer.
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| Professor Philip Newsholme | |
| Newsholme P., Gaudel C. and McClenaghan N.H. (2010) 'Nutrient Regulation of Insulin Secretion and beta cell functional integrity' In: The Islets of Langerhans. Netherlands: Springer Book Series: Advances in Experimental Medicine and Biology 654: 91-114. | |
| Professor Steffen Backert | |
| Miller, ME,Backert, S,Oyarzabal, OA (2009) 'Use of Cellulose Filters To Isolate Campylobacter spp. from Naturally Contaminated Retail Broiler Meat'. J FOOD PROTECT, 72 :2592-2596. | |
| Dr Orina Belton | |
| McCarthy C, O'Gaora P, James WG, McClelland S, Fitzgerald DJ, Belton O (2010) 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration'. Atherosclerosis . | |
| McClelland S, Cox C, O'Connor R, de Gaetano M, McCarthy C, Cryan L, Fitzgerald D, Belton O (2010) 'Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell'. Atherosclerosis, 211 (1):96-102. | |
| Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, (2009) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, 202 (1):84-91. | |
| Dr Oliver Blacque | |
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Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M. (2010) 'Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs)'. Journal of Biological Chemistry .
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| Cevik S, Hori Y, Kaplan OI, Kida K, Toivenon T, Cottell D, Katada T, Kontani K, Blacque OE. (2010) 'Joubert Syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in C. elegans'. Journal of Cell Biology . | |
| Inglis, N., Blacque OE, Leroux MR (2009) 'Functional genomics of intraflagellar transport-associated proteins in C. elegans '. Methods in Cell Biology . | |
| Dr Barry Boland | |
| Hellstrand E, Boland B, Walsh DM, Linse S (2010) 'Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process'. ACS Chemical Neuroscience, 1 (1):13-18. | |
| Professor Geraldine Butler | |
| Lynch DB, Logue ME, Butler G, Wolfe KH. (2010) 'Chromosomal G + C Content Evolution in Yeasts: Systematic Interspecies Differences, and GC-Poor Troughs at Centromeres'. Genome Biology and Evolution, 2 :572-583. | |
| Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC Genomics, 11 . | |
| Morrissey JP, Holcombe LJ, McAlester G, Munro CA, Enjalbert B, Brown AJ, Gow NA, Ding C, Butler G, O'Gara F, (2010) 'Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans'. Microbiology (Reading, England), 156 :1476-1486. | |
| Haynes K, Stead DA, Walker J, Holcombe L, Gibbs SR, Yin Z, Selway L, Butler G, Brown AJ, (2010) 'Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome'. Proteomics, 10 :212-223. | |
| Butler G, (2010) 'Fungal sex and pathogenesis'. Clinical Microbiology Reviews, 23 (1):140-159. | |
| Berriman M, Jackson AP, Gamble JA, Yeomans T, Moran GP, Saunders D, Harris D, Aslett M, Barrell JF, Butler G, Citiulo F, Coleman DC, de Groot PW, Goodwin TJ, Barrell B, Quail MA, McQuillan J, Munro CA, Pain A, Poulter RT, Rajandream MA, Renauld H, Spiering MJ, Tivey A, Gow NA, Sullivan DJ, (2009) 'Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans'. Genome Research, 19 (12):2231-2244. | |
| Dr Patrick Caffrey | |
| Murphy, B., Anderson, K., Borissow, C., Caffrey, P., Griffith, G., Hearn, J., Ibrahim, O., Khan, N., Lamburn, N., Lee, M., Pugh, K., Rawlings, B. (2010) 'Isolation and characterisation of amphotericin B analogues and truncated polyketide intermediates produced by genetic engineering of Streptomyces nodosus'. Organic and Biomolecular Chemistry, 8 :3758-3770. | |
| Eve Hutchinson, Barry Murphy, Terence Dunne, Ciaran Breen, Bernard Rawlings, Patrick Caffrey (2010) 'Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B'. Chemistry & Biology, 17 :174-182. | |
| Dr John Crean | |
| Rooney B, O'Donovan, H., Browne, M., Gaffney, A., Curran, SP., Brazil, DP. Godson, C., Sadlier, D and Crean, JK. (2010) 'CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy'. European journal of biochemistry / FEBS . | |
| Browne, JG., Ho, SL., Kadare, SJ., Kane, R., Oliver, N., Clark, AF., O'Brien, CJ., Crean, JK. (2010) 'The Effect Of CTGF On Trabecular Meshwork Cells And The Implications For Pseudoexfoliative Syndrome'. IOVS . | |
| Nyhan KC, Faherty N, Murray G, Cooey LB, Godson C, Crean JK, Brazil DP. (2010) 'Jagged/Notch signalling is required for a subset of TGFBeta1 responses in human kidney epithelial cells'. Biochima Et Biophysica Acta - Molecular Cell Research, 1803 :1386-1395. | |
| Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA. (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). | |
| Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F,Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA. (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 1 (4). | |
| Professor Paul C Engel | |
| X.-G. Wang, P. Zhang, S. Lynch and P. C. Engel (2010) 'Forced Evolution of E. coli Cells with the Ability to Effectively Utilise Non-natural Amino Acids L-tert-leucine，L-norleucine and ¡-methyl-L-leucine'. . | |
| J. Griffin & P.C. Engel (2010) 'The -SH Protection Method for Determining Accurate Kd Values for Enzyme-coenzyme Complexes of a Series of Mutant Variants of NAD+-dependent Glutamate Dehydrogenase and Engineered Mutants: Evidence for Non-productive NADPH Complexes'. Enzyme Research, 5 . | |
| Carrigan, JB,Hamza, MA,Sharkey, MA,Engel, PC,Khan, AR (2010) 'Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticus'. Graph, 66 :523-526. | |
| Marin-Menendez, A,Bell, A,Engel, PC (2010) 'Susceptibility of Plasmodium falciparum to glutamate dehydrogenase inhibitors-A possible new antimalarial target'. Molecular and Biochemical Parasitology, 172 :152-155. | |
| Frigerio, C. S.,Kukar, T. L.,Fauq, A.,Engel, P. C.,Golde, T. E.,Walsh, D. M. (2009) 'An NSAID-like Compound, FT-9, Preferentially Inhibits gamma-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1'. Biochemistry, 48 (46):10894-10904. | |
| Sharkey, M. A.,Engel, P. C. (2009) 'Modular coenzyme specificity: A domain-swopped chimera of glutamate dehydrogenase'. Proteins-Structure Function and Bioinformatics, 77 (2):268-278. | |
| Wang, X. T.,Engel, P. C. (2009) 'An optimised system for refolding of human glucose 6-phosphate dehydrogenase'. Bmc Biotechnology, 9 . | |
| Wang, X. T.,Engel, P. C. (2009) 'Clinical mutants of human glucose 6-phosphate dehydrogenase: Impairment of NADP(+) binding affects both folding and stability'. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1792 (8):804-809. | |
| Chen, S. H.,Engel, P. C. (2009) 'Efficient screening for new amino acid dehydrogenase activity: Directed evolution of Bacillus sphaericus phenylalanine dehydrogenase towards activity with an unsaturated non-natural amino acid'. Journal of Biotechnology, 142 (2):127-134. | |
| Dr Neil Ferguson | |
| Dodson, C. A., Ferguson, N, Rutherford, T. J., Johnson, C. M., Freund, S. M. V. & Fersht, A. R. (2010) 'Engineering a two-helix bundle protein for folding studies'. Protein Engineering Design and Selection, 23 (5):357-364. | |
| Professor William Gallagher | |
| Lau, T. Y., Power, K. A., Dijon, S, de Gardelle, I., McDonnell, S., Duffy, M., Pennington, S., and Gallagher, W. M. (2010) 'Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression towards clinical verification'. Journal of Proteome Research, 9 :1450-1459. | |
| Brennan, D. J., Brandstedt, J., Rexhepaj, E., Foley, M., Ponten, F., Uhlen, M., Gallagher, W. M., O'Connor, D. P., O'Herlihy, C., and Jirstrom, K (2010) '). Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer'. BMC Cancer, 10 . | |
| Lanigan, F., Gremel, G., Hughes, R., Brennan, D. J., Martin, F., Jirström, K., and Gallagher, W. M. (2010) 'Homeobox transcription factor Msx2 correlates with good prognosis in breast cancer patients and induces apoptosis in vitro'. Breast Cancer Research, 12 (4). | |
| Hoffmann, D., Adler, M., Vaidya, V., Rached, E., Mulrane, L., Gallagher, W. M., Callanan, J. J., Gautier, J. C., Matheis, K., Staedtler, F., Dieterle, F., Brandenburg, A., Sposny, A., Hewitt, P., Ellinger-Ziegelbauer, H., Bonventre, J. V., Dekant, W., and Mally, A. (2010) 'Performance of novel kidney biomarkers in preclinical toxicity studies'. Toxicological sciences : an official journal of the Society of Toxicology, 116 (1):8-22. | |
| Ryan, D., Rafferty, M., Hegarty, S., Leary, P. O., Faller, W., Gremel, G., Bergqvist, M., Agnarsdottir, M., Strömberg, S., Kampf, C., Pontén, F., Millikan, R. C., Dervan, P. A., and Gallagher, W. M (2010) 'Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis'. Pigment Cell & Melanoma Research, 23 (4):542-553. | |
| Collins, B. C., Sposny, A., McCarthy, D., Brandenburg, A., Woodbury, R., Pennington, S. R., Gautier, J. C., Hewitt, P., and Gallagher, W. M (2010) '). Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: A multi-site, multi-compound study'. Proteomics, 10 (8):1592-1608. | |
| van der Meel, R., Gallagher, W. M., Oliveira, S., O'Connor, A. E., Schiffelers, R., and Byrne, A. T (2010) 'Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies'. Drug Discovery Today, 15 (3/4):102-114. | |
| Gallagher WM, Lau TY, Power KA, Dijon S, de Gardelle I, McDonnell S, Duffy MJ, Pennington SR, (2010) 'Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification'. Journal of Proteome Research, 9 (3):1450-1459. | |
| Mally A, Hoffmann D, Adler M, Vaidya V, Rached E, Mulrane L, Gallagher WM, Callanan JJ, Gautier JC, Matheis K, Staedtler F, Dieterle F, Brandenburg A, Sposny A, Hewitt P, Ellinger-Ziegelbauer H, Bonventre JV, Dekant W, (2010) 'Performance of novel kidney biomarkers in preclinical toxicity studies'. Toxicological sciences : an official journal of the Society of Toxicology . | |
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Miller, I. S., Lynch, I., Dowling, D. P., Dawson, K. A. and Gallagher, W. M. (2010) 'Surface-induced cell signaling events control actin rearrangements and motility'. Journal of Biomedical Materials Research Part A, 93A (2):493-504.
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| Patel, K. D., Duggan, S. P., Currid, C. A., Gallagher, W. M., McManus, R., Kelleher, D., Murphy, R. T., and Ryan, A. W. (2009) '). High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of interferon gamma and interleukin-10 post myocardial infarction'. Clinical Immunology, 133 (2):251-256. | |
| Gremel, G., Rafferty, M., Lau, T. Y. K., and Gallagher, W. M. (2009) 'Identification and functional validation of therapeutic targets for malignant melanoma'. Critical Reviews in Oncology Hematology, 72 :194-214. | |
| Byrne, A. T., O'Connor, A. E., Hall, M., Murtagh, J., O¿Neill, K., Curran, K. M., Mongrain, K., Rousseau, J. A., Lecomte, R., McGee, S., Callanan, J. J., O'Shea, D. F., and Gallagher, W. M. (2009) 'Vascular targeted photodynamic therapy with BF2-chelated tetraaryl-azadipyromethene agents: A multi-modality molecular imaging approach to therapeutic assessment'. British Journal of Cancer, 101 (9):1565-1573. | |
| O¿Connor, A. E., Byrne, A. T., and Gallagher, W. M. (2009) 'Porphyrin and non-porphyrin photosensitizers in oncology: pre-clinical and clinical advances in photodynamic therapy'. Photochemistry and photobiology, 85 (5):1053-1074. | |
| McSherry, E. A., McGee, S. F., Jirstrom, K., Doyle, E. M., Brennan, D. J., Landberg, G., Dervan, P. A., Hopkins, A. M., and Gallagher, W. M. (2009) 'JAM-A expression positively correlates with poor prognosis in breast cancer patients'. International Journal of Cancer, 125 (6):1343-1351. | |
| Ryan AW, Patel KD, Duggan SP, Currid CA, Gallagher WM, McManus R, Kelleher D, Murphy RT, (2009) 'High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of Interferon Gamma and Interleukin-10 post Myocardial Infarction'. Clinical Immunology, 133 (2):251-256. | |
| Gallagher WM, Byrne AT, O'Connor AE, Hall M, Murtagh J, O'Neill K, Curran KM, Mongrain K, Rousseau JA, Lecomte R, McGee S, Callanan JJ, O'Shea DF, (2009) 'Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment'. Cancer . | |
| O Neill K, Lyons SK, Gallagher, W, Curran KM, Byrne AT (2009) 'Bioluminescent Imaging: A Critical Tool in Pre-clinical Oncology Research'. The Journal of pathology . | |
| Mcgee, SF,Jirstrom, K,Doyle, EM,Brennan, DJ,Landberg, G,Dervan, PA,Hopkins, AM,Gallagher, WM (2009) 'JAM-A expression positively correlates with poor prognosis in breast cancer patients'. International Journal of Cancer, 125 (NA):1343-1351. | |
| Byrne AT, O'Connor AE, Gallagher WM, (2009) 'Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy'. Photochemistry and photobiology, 85 (5):1053-1074. | |
| Dr Jana Haase | |
| Pfeiffer S, Boyle J, Daly S, Dowd E, Haase J, McLaughlin D. (2010) 'Human amniocytes regulate serotonin levels by active uptake, and express genes suggestive of a wider role in facilitating neurotransmitter regulation in the foetal environment'. Stem cells and development, epub . | |
| Dr Chandralal Hewage | |
| Subasinghage AP, Conlon JM, Hewage CM (2010) 'Development of potent anti-infective agents from Silurana tropicalis: conformational analysis of the amphipathic, alpha-helical antimicrobial peptide XT-7 and its non-haemolytic analogue [G4K]XT-7'. Biochimica et biophysica acta, 1804 (4):1020-1028. | |
| Dr Breandán Kennedy | |
| Atzei P, Yang F, Collery R, Kennedy BN, Moynagh PN (2010) 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'. Gene expression patterns : GEP, 10 (4-5):199-206. | |
| Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN, (2010) 'Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy'. Disease models & mechanisms, 3 (3-4):236-245. | |
| Kennedy BN, Collery RF, (2010) 'Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish'. Advances in Experimental Medical Biology, 664 :55-61. | |
| Higgins DG, Yin J, McLoughlin S, Jeffery IB, Glaviano A, Kennedy B, (2010) 'Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data'. BMC Genomics, 11 . | |
| Kennedy BN, Alvarez Y, Astudillo O, Jensen L, Reynolds AL, Waghorne N, Brazil DP, Cao Y, O'Connor JJ, (2009) 'Selective inhibition of retinal angiogenesis by targeting PI3 kinase'. PLoS ONE, 4 (11). | |
| Professor Therese Kinsella | |
| Helen M. Reid, Eamon P Mulvaney, Elizebeth C. Turner and B. Therese Kinsella. (2010) 'Interaction of the human Prostacyclin Receptor with Rab11: Characterization of a novel Rab11 binding domain (RBD) within a-Helix 8 that is regulated by Palmitoylation'. Journal of Biological Chemistry, 285 (24):18709-18726. | |
| Elizebeth C. Turner & B. Therese Kinsella (2010) 'Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERa-dependent mechanism'. Journal of Molecular Biology, 396 :473-486. | |
| AnneMarie M.Gannon & B. Therese Kinsella. (2009) 'The Wilms' Tumour suppressor protein WT1 acts as a key Transcriptional Repressor of the Human Thromboxane A2 Receptor Gene in Megakaryocytes'. Journal of cellular and molecular medicine, 13 (11-12):4571-4586. | |
| Reid HM, Kinsella BT. (2009) 'Intermolecular cross-talk between the prostaglandin E receptor (EP) subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells'. British Journal of Pharmacology, 158 (3):830-847. | |
| Gannon AM, Turner EC, Reid HM, Kinsella BT. (2009) 'Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1'. Journal of Molecular Biology, 394 (1). | |
| Dr Patricia Maguire | |
| Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB (2009) 'Canonical Wnt signaling negatively regulates platelet function'. Proceedings of the National Academy of Sciences USA, 106 (47):19836-19841. | |
| Dr Gethin McBean | |
| Kandil, S., Brennan, L. and McBean, GJ (2010) 'Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells'. Neurochemistry International, 56 :611-619. | |
| Dr Hilary McMahon | |
| McEvoy K. and McMahon H.E.M. (2009) 'Antiprion action of new cyclodextrin analogues'. Biochimica et Biophysica Acta, 1790 (10):1382-1386. | |
| Dr Tara McMorrow | |
| Martin-Martin N, Ryan G, McMorrow T, Ryan MP (2010) ''Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression'. American Journal of Physiology-Renal Physiology, 293 (3):672-682. | |
| Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. | |
| Professor Wim Meijer | |
| Dawson, T. R. M. Y., D.W. Horohov, W.G. Meijer, and G. Muscatello. (2010) 'Current understanding of the equine immune response to Rhodococcus equi: potential impact on immunoprophylaxis'. Veterinary Immunology and Immunopathology, 135 (1-2):1-11. | |
| Danilowicz, BS,Balbuena, JA,Danielsdottir, AK,Geffen, AJ,Meijer, WG,Modin, J,Montero, FE,Pampoulie, C,Perdiguero-Alonso, D,Schreiber, A,Stefansson, MO,Wilson, B (2010) 'Multi-disciplinary fingerprints reveal the harvest location of cod Gadus morhua in the northeast Atlantic'. Marine Ecology Progress Series, 404 :197-206. | |
| Dr Cormac Declan Murphy | |
| Amadio J and Murphy CD (2010) 'Biotransformation of fluorobiphenyl in Cunninghamella elegans'. Applied Microbiology and Biotechnology, 86 :345-351. | |
| S. Moran, K. Robertson, F. Paradisi, D. Rai and C.D. Murphy (2010) 'Production of lipopeptides in Bacillus sp. CS93 isolated from Pozol'. Fems Microbiology Letters, 304 (1):69-73. | |
| Murphy CD (2010) 'Biodegradation and biotransformation of organofluorine compounds'. Biotechnology Letters, 32 :351-359. | |
| Higginbotham S and Murphy CD (2010) 'Isolation and characterisation of a Streptomyces sp. isolate exhibiting activity against methicillin-resistant Staphylococcus aureus'. Microbiological Research, 165 (1):82-86. | |
| Heffernan, B. Murphy, CD,Syron, E,Casey, E (2009) 'Treatment of Fluoroacetate by a Pseudomonas fluorescens Biofilm Grown in Membrane Aerated Biofilm Reactor'. Environmental Science and Technology, 43 :6776-6785. | |
| Murphy, C., Clark, B and Amadio, J. (2009) 'Metabolism of fluoroorganic compounds in microorganisms: Impacts for the environment and the production of fine chemicals'. Applied Microbiology and Biotechnology, 84 (4):617-629. | |
| Dr Keith J Murphy | |
| O'Sullivan, Niamh C. and Croydon, Lawrence and McGettigan, Paul A. and Pickering, Mark and Murphy, Keith J. (2010) 'Hippocampal region-specific regulation of NF-kappa B may contribute to learning-associated synaptic reorganisation'. BRAIN RESEARCH BULLETIN, 81 (4-5):385-390. | |
| Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning'. Behavioural Brain Research, 213 (1):130-134. | |
| Murphy KJ, Ter Horst JP, Cassidy AW, DeSouza IE, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, O'Connor WT, Ring RH, von Schack D, Regan CM (2010) 'Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat'. Neurochemistry, 113 (3):601-614. | |
| McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 :991-1004. | |
| Murphy KJ, ter Horst JPF, Cassidy AW, DeSouza IEJ, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, William T. O'Connor WT, Ring RH, von Schack D, Regan CM (2010) 'Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat'. Journal of Neurochemistry, 113 :601-614. | |
| Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation'. Neuroscience, 166 :377-385. | |
| Professor Philip Newsholme | |
| Michalska M, Wolf G, Walther R and Newsholme P (2010) 'of the effects of pharmacologic inhibition of NADPH oxidase and iNOS on pro-inflammatory cytokine, palmitic acid or H2O2 -induced mouse islet or clonal pancreatic beta cell dysfunction'. Bioscience Reports, 30 :445-453. | |
| Newsholme P., Morgan D., Rebelato, E., Oliveira-Emilio H.C., Procopio J., Curi R. and Carpinelli A (2009) 'Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell'. Diabetologia, 52 :2489-2498. | |
| Bender K., Maechler P., McClenaghan N.H., Flatt P.R. and Newsholme P (2009) 'Overexpression of the Malate-Aspartate NADH shuttle member Aralar1 in the clonal beta cell line BRIN BD11 enhances amino acid stimulated insulin secretion and cell metabolism'. Clinical Science, 117 :321-330. | |
| Newsholme P, Homem De Bittencourt PI, O' Hagan C, De Vito G, Murphy C, Krause M. (2009) 'Exercise and possible molecular mechanisms of protection from vascular'. Clinical science (London, England : 1979), 118 (5):341-349. | |
| Dr Jens Erik Nielsen | |
| Farrell F., O'Meara F., Johnston M., Bradley J., Søndergaard C.R., Georgi N., Webb H., Tynan-Connolly B.M., Bjarnadottir U., Carstensen T., Nielsen, J. E. (2010) 'Capturing, sharing and analysing biophysical data from protein engineering and protein characterisation studies'. Nucleic Acids Research . | |
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Kukic, P. and Nielsen, J.E. (2010) 'Electrostatics in proteins and protein¿ligand complexes'. Future Medicinal Chemistry, 2 (4):647-666.
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| Higgins WJ, Fox DM, Kowalski PS, Nielsen JE, Worrall DM (2010) 'Heparin enhances serpin inhibition of the cysteine protease cathepsin L'. Journal of Biological Chemistry, 285 (6):3722-3729. | |
| Miranda, ES,Webb, H,Georgi, N,Crowley, PB,McIntosh, LP,Nielsen, JE (2010) 'Titration_DB: Storage and analysis of NMR-monitored protein pH titration curves'. Proteins, 78 :843-857. | |
| Farrell, D,Sondergaard, CR,Bjarnadottir, U,Bradley, J,Pollastri, G,Nielsen, JE (2010) 'Improving the analysis of NMR spectra tracking pH-induced conformational changes: Removing artefacts of the electric field on the NMR chemical shift'. Proteins, 78 :971-984. | |
| Dr Jasmina Nikodinovic | |
| O'Connor KE, Hume AR, Nikodinovic-Runic J, (2009) 'FadD from Pseudomonas putida CA-3 Is a True Long-Chain Fatty Acyl Coenzyme A Synthetase That Activates Phenylalkanoic and Alkanoic Acids'. Journal of Bacteriology, 191 (24):7554-7565. | |
| O'Connor KE, Nikodinovic-Runic J, Flanagan M, Hume AR, Cagney G, (2009) 'Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditions'. Microbiology (Reading, England), 155 (Pt 10):3348-3361. | |
| Dr Kathy O'Boyle | |
| Zhao Y, Zhou Y, O' Boyle KM, Murphy PV. (2010) 'Biological study of the angiogenesis inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'. Chemical Biology and Drug Design, 75 (6):570-577. | |
| Dr Darran O'Connor | |
| Brandstedt, J,Rexhepaj, E,Foley, M,Ponten, F,Uhlen, M,Gallagher, WM,O'Connor, DP,O'Herlihy, C,Jirstrom, K (2010) 'Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer'. BMC Cancer, 10 . | |
| Dr John O'Connor | |
| Batti L, Taylor CT, O'Connor JJ (2010) 'Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus'. Neuroscience, 167 (4):1014-1024. | |
| Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN, (2010) 'Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy'. Disease models & mechanisms, 3 (3-4):236-245. | |
| Batti, L., O'Connor, J.J. (2010) 'Tumor necrosis factor-α impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices'. Journal of Neuroimmunology, 218 (1-2):21-27. | |
| McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ. (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 (4):991-1004. | |
| Alvarez Y, Astudillo-Fernandez O,Jensen, L,Reynolds, AL,Waghorne, N,Brazil, DP,Cao, YH,O'Connor, JJ,Kennedy, BN (2009) 'Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase'. PLoS ONE, 4 (11):1-10. | |
| Dr James O'Gara | |
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Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E. (2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'. Journal of Applied Microbiology, 109 (6):2105-2117.
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| Oduwole KO, Glynn AA, Molony DC, Murray D, Rowe S, Holland LM, McCormack DJ, O'Gara JP (2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'. Journal of Orthopaedic Research, 28 :1252-1256. | |
| Collins, J., Rudkin, J., Recker, M., Pozzi, C., O'Gara, J. P. and Massey, R. C. (2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'. The ISME Journal, 4 :577-584. | |
| Cue, D., Lei, M.G., Luong, T.T., Kuechenmeister, L., Dunman, P.M., O'Donnell, S., Rowe, S., O'Gara, J.P. and C.Y. Lee (2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'. Journal of Bacteriology, 191 (20):6363-6373. | |
| Cotter, J.J., O'Gara, J. P. and E. Casey (2009) 'Rapid depletion of dissolved oxygen in 96 well microtitre plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'. Biotechnology and Bioengineering, 103 (5):1042-1047. | |
| Stevens, N., Greene, C.M., O'Gara, J. P. and Humphreys, H. (2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'. Journal of Medical Microbiology, 58 (7):855-862. | |
| Dr Mark Pickering | |
| O'Sullivan, Niamh C. and Croydon, Lawrence and McGettigan, Paul A. and Pickering, Mark and Murphy, Keith J. (2010) 'Hippocampal region-specific regulation of NF-kappa B may contribute to learning-associated synaptic reorganisation'. BRAIN RESEARCH BULLETIN, 81 (4-5):385-390. | |
| O'Sullivan NC, Pickering M, Di Giacomo D, Loscher JS, Murphy KJ (2010) 'Mkl transcription cofactors regulate structural plasticity in hippocampal neurons'. Cerebral cortex (New York, N.Y. : 1991), 20 (8):1915-1925. | |
| Professor Ciaran Regan | |
| Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning'. Behavioural Brain Research, 213 (1):130-134. | |
| Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM (2010) 'Aβ oligomers inhibit synapse remodelling necessary for memory consolidation'. Neurobiology of Aging . | |
| Murphy KJ, ter Horst JPF, Cassidy AW, DeSouza IEJ, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, William T. O'Connor WT, Ring RH, von Schack D, Regan CM (2010) 'Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat'. Journal of Neurochemistry, 113 :601-614. | |
| Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010) 'Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation'. Neuroscience, 166 :377-385. | |
| McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 :991-1004. | |
| Regan CM, Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, (2009) 'H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms'. Neuropsychopharmacology, 34 (12):2585-2600. | |
| Professor Dominic Walsh | |
| Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM (2010) 'Aβ oligomers inhibit synapse remodelling necessary for memory consolidation'. Neurobiology of Aging . | |
| Savva, GM,Brayne, C,Welzel, AT,Forster, G,Shankar, GM,Selkoe, DJ,Ince, PG,Walsh, DM,Med Res Council Cognitive Function (2010) 'The presence of sodium dodecyl sulphate-stable A beta dimers is strongly associated with Alzheimer-type dementia'. Brain, 133 :1328-1341. | |
| Boland, B,Walsh, DM,Linse, S (2010) 'Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process'. Neuroscience, 1 :13-18. | |
| Fadeeva, JV,Minogue, AM,Citron, M,Van Leuven, F,Staufenbiel, M,Paganetti, P,Selkoe, DJ,Walsh, DM (2010) 'beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins'. FEBS Journal, 277 :1503-1518. | |
| Blennow K, Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, (2009) 'Biological markers of amyloid beta-related mechanisms in Alzheimer's disease'. Experimental Neurology . | |
| Sala Frigerio C, Kukar TL, Engel PC, Golde TE, Walsh DM (2009) 'An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of APP compared to its effect on APLP1'. Biochemistry . | |
| Dr Margaret Worrall | |
| Higgins WJ, Fox DM, Kowalski PS, Nielsen JE, Worrall DM (2010) 'Heparin enhances serpin inhibition of the cysteine protease cathepsin L'. Journal of Biological Chemistry, 285 (6):3722-3729. | |
| Professor Philip Newsholme | |
| . Newsholme P, Homem De Bittencourt PI, O' Hagan C, De Vito G, Murphy C, Krause MS (2010) 'Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide' Clinical Science Lon, 118 . | |
| Dr Orina Belton | |
| McCarthy C, Mooney D, Fitzgerald DJ, Belton O (2010) Identification of a PGC1a regulated network induced by conjugated linoleic acid in the regression of atherosclerosis In Atherosclerosis Thrombosis and Vascular Biology, | |
| McCarthy C, James W, Fitzgerald DJ, Belton O (2010) Novel regulation and recognition of the role of SorLA in atherosclerotic vasculature Keystone Symposia Advances in Molecular Mechanisms in Atherosclerosis 2010, | |
| Dr John Crean | |
| Browne, M., Faherty, N.1, Xu, L., Oliver, N., Brazil, D. , Godson, C. and Crean, J. (2010) Connective Tissue Growth Factor (CTGF) causes Cdc42 activation and altered actin binding protein expression in the glomerular podocyte J Am Soc Nephrol, | |
| Rooney B, Gaffney, A., Godson, C., Sadlier, D and Crean, JK. (2010) CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy J Am Soc Nephrol, | |
| O'Donovan, H. 1, Xu, L.3, Oliver, N.3, Godson, C.2, and Crean, JK (2010) CTGF/CCN2 and TGFBeta Superfamily signalling: Implications for therapeutic intervention J Am Soc Nephrol, | |
| Dr Carmel Hensey | |
| Aparicio, I. M.; Hensey, C.; Lonergan, P.; Fair, T., (2010) Expression and regulation of genomic and non-genomic progestrone receptors in bovine cumulus oocyte complexes during maturation in vitro so reproduction fertility and development Reprod. Fertil. Dev, | |
| Dr Caroline Herron | |
| Herron, C.E and Metais, C (2010) Effects of Chronic and Acute Simvastatin on Neuronal Excitability and LTP in APPswe/PS1dE9 mice International Conference on Alzheimer's Disease, 10-A-1167-ALZ | |
| Herron C.E and Metais, C (2010) Effects of simvastatin on synaptic transmission and LTP in the hippocampal CA1 region in APPSWE/PS19ED and control mice European Winter conference for Brain Research, France, | |
| Metais, C and Herron C.E (2010) Chronic simvastatin treatment reduces plasma cholesterol and attenuates the impairment of long-term potentiation in APP/PS1DE9 mouse hippocampal slices Royal Academy of Medicine in Ireland, Dublin, | |
| Metais C and Herron CE (2009) Effects of acute and chronic simvastatin on synaptc transmission and LTP in the CA1 region of mouse hippocampal slices American Society for Neuroscience, | |
| Professor Therese Kinsella | |
| B. Therese Kinsella (2010) Biochemistry of the Prostacyclin Receptor Bioactive Lipids: Biochemistry and Diseases. Keystone Symposia on Molecular and Cellular Biology, Kyoto, Japan, | |
| Reid HR, Mulvaney EP. Turner EC & Kinsella BT. (2010) Characterization of a novel Rab11 binding domain (RBD) within the human prostacyclin receptor that is regulated by palmitoylation . In: FASEB J. 2010. 24:771.9 eds. Experimental Biology 2010, Anaheim, CA, USA. April 24th ¿ 28th 2010, Anaheim, CA, USA, | |
| Dr Tara McMorrow | |
| H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow (2010) Metabolomic Analysis in Immunosuppressant Nephropathy Irish Nephrological Society Conference, Dublin, Ireland, | |
| H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow (2010) Metabolomic Analysis of Human Immunosuppressant Nephropathy Post Renal Transplantation . In: Irish Journal of Medical Science eds. Proceedings of the Royal Academy of Medicine in Ireland, Dublin, Ireland, 179 | |
| Bloch K., Lock E.A., Jennings P., Limonciel A., Aschauer L., Boei J., Radford R., McMorrow T., Slattery C., Ryan M.P. (2009) Cytotoxicity Studies With Two Renal Carcinogens In Human And Rat Renal Tubule Epithelial Cells In Vitro Toxicology Society Meeting, Liverpool, United Kingdom, Liverpool, United Kingdom, | |
| Professor Philip Newsholme | |
| Farrelly M, Murphy C and Newsholme P (2010) Effects of pro-inflammatory cytokines on pancreatic alpha cell response to glucose, Zn2+ and Insulin Diabetologia, | |
| Krause M, Homem de Bittencourt PI and Newsholme P. (2010) Exercise-Associated concentrations of IL-6 exerts a positive modulation of insulin secretion, signal transduction, nitric oxide release and redox status in a clonal pancreatic beta cell line. OP-BC01-1 15th annual Congress of theEuropean College of Sports Science, Turkey, | |
| Rodrigues-Krause JC, Krause MS, Newsholme P, Cunha GS, Perin DS, Schaun MI, Bijoldo MJ, Alberton CL, Fernandes JR, Oliveira AR (2010) Ballet Dancer Cardiorespiratory, Oxidative and Muscle Responses to Classes and Rehearsals. PP-SM09-5 15th annual Congress of theEuropean College of Sports Science, Turkey, | |
| Dr Kathy O'Boyle | |
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O'Neill, G., Doyle, E., O'Boyle, K., Clipson, N. (2010) Choice of Assessment Methods within a Module: Students Experiences and Staff Recommendations for Practice AISHE-C 2010:, Dublin,
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| Dr John O'Connor | |
| Watters O, O'Connor JJ (2010) Modulatory effects of TNFalpha and glutamate pretreatment on calcium homeostasis and glutamate-induced calcium influx in rat organotypic hippocampal cultures Royal academy of medicine in Ireland biomedical sciences section annual meeting 2010, | |
| Corcoran AE, O'Connor JJ (2010) Acute effects of prolyl hydroxylase inhibiton on synaptic transmission and plasticity in the hippocampal rat slice Royal Academy of medicine in Ireland Biomedical sciences section annual meeting 2010, | |
| Dr Kathy O'Boyle | |
| Dr. Jonathan Drennan Dr Corina Naughton Ms Deirdre Allen Dr. Abbey Hyde Dr. Pat Felle Dr. Kathy O'Boyle Professor Pearl Treacy Dr. Michelle Butler (2009) National Independent Evaluation of the Nurse/Midwife Prescribing Initiative. Dublin, Dublin. | |
| Professor Therese Kinsella | |
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Nataya Anderson about the work of BT Kinsella & EC Turner (2010) Estrogen's use as a protector against cardiovascular disease. Irish Medical Times: Newspaper Articles.
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B. Therese Kinsella & Elizebeth C. Turner (2010) Researchers discover how oestrogen protects against heart disease. HRB Website: Website article.
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