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Finding Colour In a Black & White World. Image by Dr. Breandan Kennedy.

Finding Colour In a Black & White World. Image by Dr. Breandan Kennedy.

UCD Biomolecular & Biomedical Science

UCD School of Biomolecular & Biomedical Science - Research Publications 2012/13

Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2012/13.




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Books

Professor Jan Rosier
J. Rosier, M. Martens and J. Thomas (2013) An introduction to New Drug Development. London: Wiley Blackwell.  


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Book Chapters

Dr Gerard Cagney
Watson A, Cagney G (2013) 'Proteome Analysis of Chromatin Complexes in Differentiating Stem Cells' In: A Emili, J Greenblatt, S Wodak (eds). Systems Analysis of Chromatin-Related Protein Complexes in Cancer. New York: Springer.  
Dr Gethin McBean
McBean, G.J. (2013) 'The thiol redox system in glioma biology: clinical target and significance in resistance to glioma therapy' In: Wiranowska, M. and Vrionis, F.D., Eds (eds). Gliomas: symptoms, diagnosis and treatment options. New York: Nova Science Publishers. , pp.321-340  
McBean, G.J. (2012) 'Astrocytes and the regulation of cerebral cysteine/cystine redox potential: implications for cysteine neurotoxicity' In: Chorkina, F.V. and Karatev, A.I., Eds (eds). Cysteine: biosynthesis, chemical structure and toxicity. New York: Nova Science Publishers. , pp.135-153  
Dr Cormac Declan Murphy
Murphy, C. and Clark, B.; (2013) 'Enzymatic halogenation in stereoselctive synthesis' In: Andrushko, V. and Andrushko, N (eds). Stereoselective synthesis of drugs and natural products. New York: Wiley-Blackwell. , pp.1377-1398  
Dr David O'Connell
David O'Connell, Mikael Bauer, Sara Linse; (2013) 'Calmodulin' In: David O'Connell, Mikael Bauer, Sara Linse; (eds). Encyclopedia of Metalloenzymes. New Dehli: Springer.  
Professor Ciaran Regan
Regan CM (2013) 'The Addicted Self: A Neuroscientific Perspective' In: Regan CM (eds). Intoxication and Society: Problematic Pleasures of Drugs and Alcohol. London: Palgrave MacMillan.  
Herring J, Regan CM, Weinberg D, Withington P (2013) 'Starting the conversation' In: Herring J, Regan CM, Weinberg D, Withington P (eds). Intoxication and Society: Problematic Pleasures of Drugs and Alcohol. London: Palgrave MacMillan.  


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Books Edited

Professor Ciaran Regan
Herring J, Regan CM, Weinberg D, Withington P (Ed.). (2013) Intoxication and Society: Problematic Pleasures of Drugs and Alcohol. London: Palgrave MacMillan.  


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Peer Reviewed Journals

Professor Steffen Backert
Roure S, Bonis M, Chaput C, Ecobichon C, Barrière C, Geldmacher N, Guadagnini N, Schmitt C, Prévos, M-C, Labigne A, Backert S, Ferrero RL, Boneca IG (2012) 'Peptidoglycan maturation enzymes control flagellar functionality in bacteria'. Molecular Microbiology .  
Dr Orina Belton
McCarthy C, Duffy MM, Mooney D, James WG, Griffin MD, Fitzgerald DJ, Belton O (2013) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. FASEB Journal, 27 (2):499-510.  
McCarthy, C,Duffy, MM,Mooney, D,James, WG,Griffin, MD,Fitzgerald, DJ,Belton, O (2013) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27 :499-510.  
Reynolds, CM,Toomey, S,McBride, R,McMonagle, J,Morine, MJ,Belton, O,Moloney, AP,Roche, HM (2013) 'Divergent effects of a CLA-enriched beef diet on metabolic health in ApoE(-/-) and ob/ob mice'. J Nutr Biochem, 24 :401-411.  
McCarthy C, Duffy MM, Mooney D, James WG, Griffin MD, Fitzgerald DJ, Belton O. (2012) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. FASEB Journal, [Epub ahead of print] .  
Dr Oliver Blacque
Olivier-Mason A, Wojtyniak M, Bowie RV, Nechipurenko IV, Blacque OE, Sengupta P (2013) 'Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans'. Development, 140 (7):1560-1572.  
Professor Geraldine Butler
Mohan Pammi, Linda Holland, Geraldine Butler, Attila Gacser, Joseph M. Bliss (2013) 'Candida parapsilosis is a Significant Neonatal Pathogen: A Systematic Review and Meta-analysis'. Pediatric Infectious Disease Journal, 32 (5):206-216.  
Connolly LA, Riccombeni A, Grózer Z, Holland LM, Lynch DB, Andes DR, Gácser A, Butler G. (2013) 'The APSES transcription factor Efg1 is a global regulator that controls morphogenesis and biofilm formation in Candida parapsilosis'. Molecular Microbiology, 90 (1):36-53.  
Maguire SL, Ohéigeartaigh SS, Byrne KP, Schröder MS, O'Gaora P, Wolfe KH, Butler G (2013) 'Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB'. Molecular Biology and Evolution, 30 (6):1281-1291.  
Butler, G. (2013) 'Hypoxia and Gene Expression in Eukaryotic Microbes'. Annual Review of Microbiology, 67 :291-312.  
Gioti, A,Nystedt, B,Li, WJ,Xu, J,Andersson, A,Averette, AF,Munch, K,Wang, XY,Kappauf, C,Kingsbury, JM,Kraak, B,Walker, LA,Johansson, HJ,Holm, T,Lehtio, J,Stajich, JE,Mieczkowski, P,Kahmann, R,Kennell, JC,Cardenas, ME,Lundeberg, J,Saunders, CW,Boekhout, T,Dawson, TL,Munro, CA,de Groot, PWJ,Butler, G,Heitman, J,Scheynius, A (2013) 'Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis'. mBio, 4 (1).  
Alessandro Riccombeni and Geraldine Butler (2012) 'Role of Genomics and RNA-seq in Studies of Fungal Virulence'. Current Fungal Infection Reports, 6 :274-297.  
Dr Patrick Caffrey
Niamh Stephens, Bernard Rawlings, Patrick Caffrey (2013) 'Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis'. Bioscience Biotechnology and Biochemistry, 77 (4):880-883.  
Dr Gerard Cagney
Di Cara F, Duca E, Dunbar DR, Cagney G, Heck MM. (2013) 'Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila'. Journal of Cell Science, 126 :4769-4781.  
Casey WT, Nikodinovic-Runic J, Fonseca Garcia P, Guzik MW, McGrath JW, Quinn JP, Cagney G, Prieto MA, O'Connor KE (2013) 'The effect of polyphosphate kinase gene deletion on polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida?KT2440'. Environmental Microbiology, 5 :740-746.  
Ryan CJ, Krogan NJ., Cunningham P, Cagney, G. (2013) 'All or nothing: protein complexes flip essentiality between distantly related eukaryotes'. Genome Biology and Evolution . Available Online  
Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ (2013) 'Quantitative genetic-interaction mapping in mammalian cells'. Nature Methods, 10 (5):432-437.  
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. (2012) 'Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation'. Nature structural & molecular biology, 19 (12):1273-1281.  
Dr John Crean
Faherty, N., O'Donovan, H., Kavanagh, D., madden, S., McKay, GJ, Maxwell, AP., Martin, F., Godson, C and Crean, J. (2013) 'TGFβ and CCN2/CTGF mediate actin related gene 3 expression by differential E2F1/CREB activation'. BMC Genomics .  
David H Kavanagh, David A Savage, Christopher C Patterson, Amy Jayne McKnight John Crean, Alexander P Maxwell, Gareth J McKay. (2013) 'Haplotype association analysis of genes within the WNT signalling pathways indiabetic nephropathy BMC Nephrology 2013, 14:126'. Nephrology .  
Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP (2013) 'Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy'. FEBS Journal .  
Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, and Crean J (2012) 'CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes'. Journal of Cell Science .  
Professor Paul Engel
Munawar, N,Engel, PC (2013) 'Prospects for robust biocatalysis: engineering of novel specificity in a halophilic amino acid dehydrogenase'. Extremophiles, 17 :43-51.  
Xuejing Yu, Julia Bresser, Iris Schall, Ivana Djurdjevic, Wolfgang Buckel, Xingguo Wang and Paul C. Engel (2012) 'Development of a satisfactory and general continuous assay for aminotransferases by coupling with (R)-2-hydroxyglutarate dehydrogenase'. Analytical Biochemistry, 431 (2):127-131. Available Online  
Sharkey MA, Gori A, Capone M and Engel PC (2012) 'Reversal of the extreme coenzyme selectivity of Clostridium symbiosum glutamate dehydrogenase'. FEBS Journal, 279 (17):3003-3009.  
Professor William Gallagher
Madden S. F., Clarke C., Aherne S. T., Gaule P., O'Donovan N., Crown J., Clynes M., Gallagher W.M. (2013) 'BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome'. Breast Cancer Research, 15 (4).  
Clarke C, Madden SF, Doolan P, Aherne ST, Joyce H, O' Driscoll L, Gallagher WM, Hennessy BT, Moriarty M, Crown J, Kennedy S, Clynes M (2013) 'Correlating transcriptional networks to breast cancer survival: A large-scale coexpression analysis'. Carcinogenesis .  
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR. (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753.  
Rexhepaj E, Agnarsdóttir M, Bergman J, Edqvist PH, Bergqvist M, Uhlén M, Gallagher WM, Lundberg E, Ponten F. (2013) 'A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections'. PLoS ONE, 8 (5).  
O'Connor S, Szwej E, Nikodinovic-Runic J, O'Connor A, Byrne AT, Devocelle M, O'Donovan N, Gallagher WM, Babu R, Kenny ST, Zinn M, Zulian QR, O'Connor KE (2013) 'The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate'. Biomaterials, 34 (11):2710-2718.  
O Leary PC, Penny SA, Dolan RT, Kelly CM, Madden SF, Rexhepaj E, Brennan DJ, McCann AH, Pontén F, Uhlén M, Zagozdzon R, Duffy MJ, Kell MR, Jirström K, Gallagher WM (2013) 'Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer'. BMC Cancer, 13 (175).  
Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG. (2013) 'Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses'. Cancer Research, 73 (3):1128-1141.  
Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O'Connor DP (2012) 'miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro'. Clinical Cancer Research .  
Dr Jana Haase
Malynn, S,Campos-Torres, A,Moynagh, P,Haase, J (2013) 'The Pro-inflammatory Cytokine TNF-alpha Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes'. Neurochemical Research, 38 :694-704.  
Dr Chandralal Hewage
Hewage CM, Venneti KC (2013) 'Structural aspects of gut peptides with therapeutic potential for type 2 diabetes'. Chemmedchem, 8 (4):560-567.  
Kenny, O., Smyth, T. J., Hewage, C. M., Brunton, N. P (2013) 'Antioxidant properties and quantitative UPLC-MS analysis of phenolic compounds from extracts of fenugreek (Trigonella foenum-graecum) seeds and bitter melon (Momordica charantia) fruit'. Food Chemistry, 141 (4):4295-4302.  
Dr Breandán Kennedy
Collery RF, Cederlund ML, Kennedy BN (2013) 'Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology'. Experimental Eye Research .  
Collery, RF,Cederlund, ML,Kennedy, BN (2013) 'Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology'. Experimental Eye Research, 108 :120-128.  
Jun Yin1, Lisa Shine2, Francis Raycroft3, Sudhakar Deeti2, Alison Reynolds2, Kristin M. Ackerman3, Antonino Glaviano2, Sean O'Farrell2, Olivia O'Leary2, Claire Kilty2, Ciaran Kennedy2, Sarah McLoughlin2, Megan Rice2, Eileen Russell2, Desmond G. Higgins1, David R. Hyde3 & Breandan N. Kennedy2* (2012) 'INHIBITION OF THE PIM1 ONCOGENE RESULTS IN DIMINISHED VISUAL FUNCTION'. PLoS ONE .  
Professor Therese Kinsella
Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. (2013) 'Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1'. PLoS ONE, 8 (2).  
Turner EC, Kinsella BT. (2012) 'Regulation of the Human Prostacyclin Receptor Gene by the Cholesterol-responsive Sterol Response Element Binding Protein (SREBP) 1'. Journal of lipid research, 53 (11):2390-2402.  
Dr Patricia Maguire
Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB (2013) 'Canonical Wnt signaling in megakaryocytes regulates proplatelet formation'. Blood, 121 (1):188-196.  
Professor Jonathan Malthouse
Howe N, Ceruso M, Spink E, Malthouse JP; (2012) 'pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor'. Biochimica et biophysica acta, 1814 (10):1394-1403.  
Petrillo T, O'Donohoe CA, Howe N, Malthouse JPG (2012) 'Importance of tetrahedral intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin and subtilisin'. Biochemistry, 51 (31):6164-6170.  
Dr Margaret McGee
O'Donovan DS, MacFhearraigh S, Whitfield J, Swigart LB, Evan GI, Mc Gee MM (2013) 'Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death'. Cell Death & Disease .  
Dr Tara McMorrow
H. Cassidy, J.Slyne, H. Frain, C. Slattery , M.P. Ryan, T. McMorrow * (2013) 'High-Throughput Proteomic Approaches to the Elucidation of Potential'. Proteome science, 1 (2):159-179.  
Radford R, Frain H, Ryan MP, Slattery C, McMorrow T. (2013) 'Mechanisms of chemical carcinogenesis in the kidneys'. International journal of molecular sciences, 14 (10):19416-19433.  
Sumayao R, McEvoy B, Martin-Martin N, McMorrow T, Newsholme P. (2013) 'Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line'. Experimental Physiology, 98 (10):1505-1517.  
Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. (2012) 'Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells'. Archives of Toxicology, 86 (11):1741-1751.  
Professor Wim Meijer
Liu, L; Tharmalingam, T; Maischberger, E; Miranda CasoLuengo, R; Meijer, WG; Rudd, PM; Irwin, JA (2013) 'A HPLC-based glycoanalytical protocol allows the use of natural O-glycans derived from glycoproteins as substrates for glycosidase discovery from microbial culture'. Glycoconjugate journal, 30 (8):791-800.  
Maischberger, E; Cummins, CA; Fitzpatrick, E; Gallagher, ME; Worrall, S;Rousseau, K; Thornton, DJ; Meijer, WG; Miranda-CasoLuengo, R; Duggan, VE;Carrington, SD; Irwin, JA; Reid, CJ (2013) ''The expression of mucin genes and the presence of mucin gene products in the equine endometrium''. Research in Veterinary Science, 95 (1):169-175.  
Sinigalliano, C.D., J. Erven, L.C. van de Werfhorst, B. Badgley, E. Balleste, J. Bartkowiak, A.B. Boehm, M. Byappanahalli, K.D. Goodwin, M. Gourmelon, J. Griffith, P.A. Holden, J. Jay, B. Layton, C. Lee, J. Lee, W.G. Meijer, R. Noble, M. Raith, H. Ryu, M/J. Sadowsky, A. Schriewer, D. Wanless, R. Whitman, S. Wuertz, J.W. Santo Domingo (2013) 'Multi-laboratory evaluations of the performance of Catellicoccus marimammalium PCR assays developed to target gull fecal sources'. Water Research, 47 (18):6883-6896.  
Schriewer, A; Goodwin, KD; Sinigalliano, CD; Cox, A; Wanless, D; Bartkowiak, J; Ebentier, DL; Hanley, KT; Ervin, J; Deering, LA; Shanks, OC; Peed, LA; Meijer, WG; Griffith, JF; SantoDomingo, J; Jay, JA; Holden, PA; Wuertz, S (2013) 'Performance evaluation of canine-associated Bacteroidales assays in a multi-laboratory comparison study'. Water Research, 47 (18):6909-6920.  
Raith, MR; Kelty, CA; Griffith, JF; Schriewer, A; Wuertz, S; Mieszkin, S; Gourmelon, M; Reischer, GH; Farnleitner, AH; Ervin, JS; Holden, PA; Ebentier, DL; Jay, JA; Wang, D; Boehm, AB; Aw, TG; Rose, JB; Balleste, E; Meijer, WG; Sivaganesan, M; Shanks, O (2013) 'Comparison of PCR and quantitative real-time PCR methods for the characterisation of ruminant and cattle fecal pollution sources'. Water Research, 47 (18):6921-6928.  
Layton, BA; Cao, Y; Ebentier, DL; Hanley, K; Ballesté, E; Brandão, J; Byappanahalli, M; Converse, R; Farnleitner, AH; Gentry-Shields, J; Gidley, ML; Gourmelon, M; Lee, CS; Lee, J; Lozach, S; Madi, T; Meijer, WG; Noble, R; Peed, L; Reischer, GH; Rodrigues, R; Rose, JB; Schriewer, A; Sinigalliano, C; Srinivasan, S; Stewart, J; Van De Werfhorst, LC; Wang, D; Whitman, R; Wuertz, S; Jay, J; Holden, PA; Boehm, AB; Shanks, O; Griffith, JF (2013) 'Performance of human fecal anaerobe-associated PCR-based assays in a multi-laboratory method evaluation study'. Water Research, 47 (18):6897-6908.  
Cauchard, S; Giguère, S; Venner, M; Muscatello, G; Cauchard, J; Cohen, ND; Haas, A; Hines, SA; Hondalus, MK; Horohov, DW; Meijer, WG; Prescott, JF; Vázquez-Boland, J (2013) 'Rhodococcus equi research 2008-2012: Report of the Fifth International Havemeyer Workshop'. Equine Veterinary Journal, 45 :523-526.  
Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC, Meijer WG (2013) 'A real-time impedance based method to assess Rhodococcus equi virulence'. PLoS ONE, 8 (3).  
Miranda-CasoLuengo, R., G. Coulson, A. Miranda-CasoLuengo, J.A. Vazquez-Boland, M.K. Hondalus and W.G. Meijer (2012) 'The hydroxamate siderophore rhequichelin is required for virulence of the pathogenic actinomycete Rhodococcus equi'. Infection and Immunity, 80 (12):4106-4114.  
Garcia MS, Carvalho D, Zlydareva O, Muldoon C, Masterson BF, O'Grady MJ, Meijer,WG, O'Sullivan JJ, O'Hare GMP (2012) 'An agent-based wireless sensor network for water quality data collection'. Lecture Notes in Computer Science, 7656 .  
Dr Cormac Declan Murphy
Amadio, J; Casey, E; Murphy, CD (2013) 'Filamentous fungal biofilm for production of human drug metabolites'. Applied Microbiology and Biotechnology, 97 (13):5955-5963.  
Murphy, CD; Casey,E (2013) 'Biofilm-catalysed transformation of organofluorine compounds'. Chimica Oggi-Chemistry Today, 31 (3):6-10.  
Kavanagh, E; Winn, M; NicGabhann, C; O'Connor, NK; Beier, P; Murphy CD (2013) 'Microbial biotransformation of aryl sulfanylpentafluorides'. Environmental Science and Pollution Research .  
Bright, T; Dalton,F; Elder, VL; Murphy, CD; O'Connor, NK; Sandford, G (2013) 'A convenient chemical-microbial method for developing fluorinated pharmaceuticals'. Organic and Biomolecular Chemistry, 11 (7):1135-1142.  
O'Connor NK, Rai DK, Clark BR, Murphy CD (2012) 'Production of the Novel Lipopeptide Antibiotic Trifluorosurfactin via Precursor-Directed Biosynthesis'. Journal of Fluorine Chemistry, 143 :210-215.  
Dr Keith Murphy
Murphy RP, Murphy KJ, Pickering M (2013) 'The development of myelin repair agents for treatment of multiple sclerosis: Progress and challenges'. Bioengineered, 4 (3):140-146.  
Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Frigerio CS, Regan CM, Murphy KJ, Masliah E, Walsh DM (2013) 'Alzheimer brain-derived amyloid beta-protein impairs synaptic remodeling and memory consolidation'. Neurobiology of Aging, 34 (5):1315-1327.  
Lukasz B, O'Sullivan NC, Loscher JS, Pickering M, Regan CM, Murphy KJ (2013) 'Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat'. Brain, behavior, and immunity, 27 (1):71-79.  
Dr Jens Erik Nielsen
Farrell D, Nielsen JE (2012) 'DataPipeline: Automated importing and fitting of large amounts of biophysical data'. Journal of Computational Chemistry, 33 (29):2357-2362.  
Dr Kathy O'Boyle
Naughton C, Drennan J, Hyde A, Allen D, O'Boyle K, Felle P, Butler M. (2013) 'An evaluation of the appropriateness and safety of nurse and midwife prescribing in Ireland'. Journal of Advanced Nursing, 69 (7):1478-1488.  
Downey, C., Daly, F., O'Boyle, KM (2013) 'An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine'. Toxicology in Vitro . Available Online  
Dr David O'Connell
Chris M. Egan,Ulrika Nyman,Julie Skotte,Gundula Streubel1,Siobhán Turner,David J. O'Connell,Vilma Rraklli,Michael J. Dolan,Naomi Chadderton,Klaus Hansen,Gwyneth Jane Farrar,Kristian Helin,Johan Holmberg, Adrian P. Bracken (2013) 'CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression'. Cell, 26 (3):223-236.  
Fields C, O'Connell D, Xiao S, Lee GU, Billiald P, Muzard J (2013) 'Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies'. Nature protocols, 8 (6):1125-1148.  
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. (2012) 'Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation'. Nature structural & molecular biology, 19 (12):1273-1281.  
Dr Darran O'Connor
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR. (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753.  
Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM & O'Connor DP (2012) 'miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro'. Clinical Cancer Research, 24 (18):6702-6713.  
Dr John O'Connor
Corcoran, A., OConnor J.J. (2013) 'Hypoxia inducible factor signaling mechanisms in the central nervous system'. Acta Physiologica Scandinavica, 208 (4):298-310.  
O'Connor JJ (2013) 'Targeting TNF-α in hypoxia and synaptic signaling'. Irish Journal of Medical Science, 182 (2):157-162.  
Fanning RA, McMorrow JP, Campion DP, Carey MF, O'Connor JJ (2012) 'Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium'. European Journal of Pharmacology, 698 (1-3):170-177.  
Dr Kevin O'Connor
Narancic T, Radivojevic J, Jovanovic P, Francuski D, Bigovic M, Maslak V, Savic V, Vasiljevic B, O'Connor KE, Nikodinovic-Runic J (2013) 'Highly efficient Michael-type addition of acetaldehyde to β-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase'. Bioresource Technology, 142 :462-468.  
Molloy S, Nikodinovic-Runic J, Martin LB, Hartmann H, Solano F, Decker H, O'Connor KE. (2013) 'Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches'. Biotechnology and Bioengineering, 110 (7):1848-1857.  
Brooks SJ, Nikodinovic J, Martin L, Doyle EM, O'Sullivan T, Guiry PJ, Coulombel L, Li Z, O'Connor KE. (2013) 'Production of a chiral alcohol, 1-(3,4-dihydroxyphenyl) ethanol, by mushroom tyrosinase'. Biotechnology Letters, 35 (5):779-783.  
O'Connor S, Szwej E, Nikodinovic-Runic J, O'Connor A, Byrne AT, Devocelle M, O'Donovan N, Gallagher WM, Babu R, Kenny ST, Zinn M, Zulian QR, O'Connor KE (2013) 'The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate'. Biomaterials, 34 (11):2710-2718.  
Babu RP, O'Connor K, Seeram R. (2013) 'Current progress on bio-based polymers and their future trends'. Progress in Biomaterials, 2 (8).  
Nikodinovic-Runic J, Guzik M, Kenny ST, Babu R, Werker A, O Connor KE (2013) 'Carbon-rich wastes as feedstocks for biodegradable polymer (polyhydroxyalkanoate) production using bacteria'. Advances In Applied Microbiology, Vol 62, 84 :139-200.  
Dr Niamh O'Sullivan
O'Sullivan NC, Dräger N, O'Kane CJ. (2013) 'Characterisation of the Drosophila Atlastin Interactome Reveals VCP as a Functionally Related Interactor'. Yi chuan xue bao = Acta genetica Sinica . Available Online  
Lukasz B, O'Sullivan NC, Loscher JS, Pickering M, Regan CM, Murphy KJ (2013) 'Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat'. Brain, behavior, and immunity, 27 (1):71-79.  
Professor Ciaran Regan
Ring RM, Regan CM (2013) 'Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism'. Journal of psychopharmacology (Oxford, England) .  
Lukasz B, O'Sullivan NC, Loscher JS, Pickering M, Regan CM, Murphy KJ (2013) 'Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat'. Brain, behavior, and immunity, 27 (1):71-79.  
Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Frigerio CS, Regan CM, Murphy KJ, Masliah E, Walsh DM (2013) (2013) 'Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation'. Neurobiology of Aging, 34 :1315-1327.  
Foley AF, Gannon S, Rombach-Mullan N, Prendergast A, Barry C, Cassidy AW, Regan CM (2012) 'Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorders'. Neuropharmacology .  
Professor Jan Rosier
Rosier J. and Goffin, K. (2013) 'The role of the CEO in innovationin life science R&D firms: the Detection of CEO Absorptive Capacity'. Journal of Product Innovation Management .  
Rosier J. and Goffin, K. (2013) 'A systematic review of the literature on the role of the Chief Executive Officer in Innovatio'. International Journal of Management Reviews .  
Dr Michael Sharkey
Sharkey MA, Gori A, Capone M, Engel PC (2012) 'Reversal of the extreme coenzyme selectivity of Clostridium symbiosum glutamate dehydrogenase'. FEBS Journal, 279 (17):3003-3009.  
Dr Peadar Ó Gaora
Maguire SL, Ohéigeartaigh SS, Byrne KP, Schröder MS, O'Gaora P, Wolfe KH, Butler G (2013) 'Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB'. Molecular Biology and Evolution, 30 (6):1281-1291.  


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Conference Publications

Dr John Crean
Kavanagh, D., Gaffney A., Murphy, M., Faherty, N., Andrews, D., Higgins, D., McKay, G., Maxwell, P., Godson, C. and Crean, J. (2012) Wnt 6 is increased in diabetic nephropathy and modulates de novo tubulogenesis and opposes TGFbeta mediated epithelial cell differentiation in vitro American Society of Nephrology,  
Dr Caroline Herron
Bláthnaid Hughes, Caroline Herron (2013) Effects of Cannabidiol on Beta Amyloid Mediated Attenuation of Long Term Potentiation in the CA1 Region of Mouse Hippocampal Slices British Neuroscience Association, BNA Proc. on line abstracts, P2-F-055  
Blathnaid Hughes, Darren Walsh, Eoin Minnock, Caroline Herron (2013) Beta Amyloid mediated blockade of Long Term Potentiation in the CA1 region of mouse hippocampal slices is partially attenuated by Cannabidiol The 6th European Workshop on Cannabinoid Research, British Journal of Pharmacology on line abstract, P20 - P20  
Blathnaid Hughes, Alison Sweeney, Cian Ward & Caroline Herron. (2012) An Investigation of a Role for Adenosine and Endocannabinoids and a Possible Interaction Between their Receptors, in the CA1 & Dentate Gyrus of Control and APPswe/PS1dE9 mice Neuroscience Ireland, Irish Journal of Medical Science,  
Professor Jonathan Malthouse
Petrillo, T. and Malthouse, J.P.G. (2013) How the glyoxal group contributes to serine proteases inhibition UCD Conway Institute Festival of Research, University College Dublin,  
Cleary, J. and Malthouse, J.P.G. (2013) Urokinase Plasminogen Activator, a target for glyoxal based inhibitors? UCD Conway Institute Festival of Research, University College Dublin,  
Malthouse, JPG (2013) Chair of NMR session 2, Prof. Redfield, Dr Crowley and Dr Brougham The 2nd Irish NMR Meeting, Trinity Biomedical Sciences Institute, Trinity College Dublin,  
Wild, A. and Malthouse, JPG. (2013) 13C-NMR of 13CO32- binding to an Azacryptand scaffold in aqueous solution The 2nd Irish NMR Meeting, Trinity Biomedical Sciences Institute, Trinity College Dublin,  
Professor Wim Meijer
Ahilan, S., O'Sullivan, J.J., Masterson, B., Demeter, K.,Meijer, W., O'Hare, G. (2013) A threshold based 'discounting' mechanism in the revised EU Bathing Water Directive 33rd Conference on Applied Statistics in Ireland, Kildare, Ireland,  
Sanchez, M.; O'Hare, G.M.P.; O'Grady, M.J.; Carvalho, D.; Zlydareva, O.; Muldoon, C.; Meijer, W.; O'Sullivan, J.; O'Keefe, B. (2012) An Agent-based Wireless Sensor Network for Water Quality Data Collection 6th International Conference on Ubiquitous Computing & Ambient Intelligence (UCAmI 2012), Vitoria-Gasteiz, Spain, 454 - 461  
Garcia, M.S., Carvalho, D., Zlydareva, O., Muldoon, C., Masterson, B.F., O'Grady, M.F., Meijer, W.G., O'Sullivan, J.J., O'Hare, G,M.P. (2012) An Agent-Based Wireless Sensor Network for Water Quality Data Collection . In: J. Bravo, D. Lopez-de-Ipina, F. Moya eds. 6th International Conference Ubiquitous Computing and Ambient Intelligence (UCAmI), Vitoria-Gasteiz, Spain, 454 - 461  
Bedri,Z., O'Sullivan, J.J., Corkery, A., Deering, L., Demeter, K., Meijer, W. G., O'Hare, G. and Masterson, B. (2012) Real-time Prediction System of Bathing Water Quality at Bray, Co. Wicklow, Ireland New Developments in IT & Water, Amsterdam,  
Dr Keith Murphy
Murphy RP, Keogh EA, O'Shea SD, Bowen G, Pickering M, Murphy KJ (2013) The nootropic agent nefiracetam is a potential remyelinating therapeutic in vivo XI European Meeting on Glial Cells in Health and Disease, S134  
O'Shea SD, Keogh EA, Murphy RP, Bowen G, Pickering M, Murphy KJ (2013) Exploring the mechanism of action of the novel remyelinating therapeutic nefiracetam XI European Meeting on Glial Cells in Health and Disease, S135  
Sheridan GK, Pickering M, Watters O, Halley PG, O'Sullivan NC, Mooney C, O'Connor JJ, Murphy KJ (2012) CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Society for Neuroscience Annual Meeting 2012,  
Wdowicz A, Gleize JJ, Bowen G, Murphy KJ, O'Connell DJ (2012) The calcium binding protein secretagogin is expressed in discrete cell populations in the adult rat brain and exhibits age-associated regulation Society for Neuroscience Annual Meeting 2012,  
Dr John O'Connor
Luke M. Alvey, John J. OConnor (2013) Novel interactions of succinate, lipopolysaccharide and hypoxia on synaptic transmission in the rat hippocampus in vitro Section of Biomedical Sciences, RAMI, UCC, Cork,  
C. Leyden, R.A. Fanning, D.P. Campion, J.J. OConnor (2013) A novel role for adrenergic and serotonergic signaling in the action of ergometrine in isolated term human myometrium Section of Biomedical Sciences, RAMI, UCC, Cork,  
H. Nolan, A.E. Corcoran, J.J. O'Connor (2013) The effects of hypoxia-mimetic drugs on synaptic transmission and synaptic plasticity in the dentate gyrus in vitro Section of Biomedical Sciences, RAMI, UCC, Cork,  
A. Wall, A.E. Corcoran, K. O'Halloran, J.J. O' Connor (2013) Effects of chronic intermittent hypoxia and prolyl-hydroxylase inibition on synaptic transmission and plasticity in the rat ca1 and dentate gyrus Section of Biomedical Sciences, RAMI, UCC, Cork,  
Alan E. Corcoran, John J. OConnor (2013) Acute hypoxic pre-conditioning and prolyl-hydroxylase inibition improves synaptic transmission recovery time from a subsequent hypoxic insult in the rat hippocampus Section of Biomedical Sciences, RAMI, UCC, Cork,  


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Other Publications

Dr Breandán Kennedy
Moriarity, AR,Murphy, A,Cathcart, M,Kennedy, BN,Murphy, P,McCormick, PH,O'Sullivan, JN,Mehigan, BJ (2013) Assessing novel small molecule drugs as potential new therapeutic options to treat colorectal cancer. Abstract.  
Dr John O'Connor
Corcoran, A.E., Kunze, R., Harney, S.C., Breier, G., Marti, H.H., and O’Connor, J.J. (2013) A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity. .  


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