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'Starfield'. Image Mr Darren Scully.

'Starfield'. Image Mr Darren Scully.

UCD Biomolecular & Biomedical Science

UCD School of Biomolecular & Biomedical Science - Research Publications 2014/15

Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2014/15.




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Peer Reviewed Journals

Dr Orina Belton
Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P (2015) 'Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells'. British Journal of Pharmacology .  
Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O (2015) 'Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1'. Prostaglandins and Other Lipid Mediators .  
Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ (2015) 'Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB'. Journal of inflammation (London, England), 12 (1).  
de Gaetano M, Alghamdi K, Marcone S, Belton O (2015) 'Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation'. Journal of inflammation (London, England), 12 .  
Dr Oliver Blacque
Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG, Toedt G, Kennedy J, 60 other authors, Blacque OE, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA. (2015) 'An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes'. Nature Cell Biology .  
Sanders AA, Kennedy J;Blacque OE (2015) 'Image analysis of Caenorhabditis elegans ciliary transition zone structure, ultrastructure, molecular composition, and function'. Methods in Cell Biology, 127 :323-347.  
Professor Geraldine Butler
Branco J, Silva AP, Silva RM, Silva-Dias A, Pina-Vaz C, Butler G, Rodrigues AG, Miranda IM. (2015) 'Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene'. Antimicrobial Agents and Chemotherapy, 59 :6629-6633.  
Turner SA, Butler G (2014) 'The Candida Pathogenic Species Complex'. Cold Spring Harbor Perspectives in Medicine, 4 .  
Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A, Ames L, Haynes K, Higgins DG, Butler G. (2014) 'Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans'. PLoS Pathogens, 10 .  
Dr Patrick Caffrey
Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard Rawlings, Patrick Caffrey (2015) 'Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane'. Bioorganic and Medicinal Chemistry, 23 (17):5782-5788.  
Dr Gerard Cagney
Munawar N, Olivero G;Jerman E;Doyle B;Streubel G;Wynne K;Bracken A;Cagney G (2015) 'Native gel analysis of macromolecular protein complexes in cultured mammalian cells'. Proteomics .  
Farrelly L, Föcking M; Piontkewitz Y; Dicker P; English J; Wynne K; Cannon M; Cagney G; Cotter DR (2015) 'Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence'. Developmental Neuroscience, 37 (1):43-55.  
Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cotter DR, Cagney G (2015) 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'. Molecular Psychiatry .  
Dr Judith Coppinger
Chiang WC, Kroeger H;Sakami S;Messah C;Yasumura D;Matthes MT;Coppinger JA;Palczewski K;LaVail MM;Lin JH (2015) 'Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration'. Molecular Neurobiology, 52 (1):679-695.  
Pasillas, M.P. and Shields, S. and Reilly, R. and Strnadel, J. and Behl, C. and Park, R. and Yates, J.R., III and Klemke, R. and Gonias, S.L. and Coppinger, J.A. (2015) 'Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation'. Molecular and Cellular Proteomics, 14 (1):1-14. Available Online  
Dr Derek Costello
D.A. Costello, D.G. Carney, M.A. Lynch (2015) 'α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR'. Brain, Behavior, and Immunity, 46 :70-79.  
J.P. Barrett, D.A. Costello, J. O'Sullivan, T.R. Cowley & M.A. Lynch (2015) 'Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli'. Journal of Neuroinflammation, 12 (67).  
Dr Eugene Dempsey
Freeley M, Derrick E, Dempsey E, Hoff A, Davies A, Leake D, Vermeulen A, Kelleher D, Long A (2015) 'RNAi Screening with Self-Delivering, Synthetic siRNAs for Identification of Genes That Regulate Primary Human T Cell Migration'. Journal of Biomolecular Screening, 20 (8):943-956.  
Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F (2015) 'Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells'. Cancer medicine, 4 (5):745-758.  
Professor William Gallagher
O'Hurley G, Busch C, Fagerberg L, Hallström BM, Stadler C, Tolf A, Lundberg E,Schwenk JM, Jirström K, Bjartell A, Gallagher WM, Uhlén M, Pontén F (2015) 'Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer'. PLoS ONE, 10 (8).  
Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Martínez-Cardús A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal A,Martinez-Iniesta M, Manzano JL,Fernandez-Figueras MT, Elez E, Muñoz-Couselo E,Botella-Estrada R, Berrocal A, Pontén F, Oord Jv, Gallagher WM, Frederick DT,Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M (2015) 'Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR'. Nature Medicine, 21 (7):741-750.  
van den Hurk K, Balint B, Toomey S, O'Leary PC, Unwin L, Sheahan K, McDermott EW, Murphy I, van den Oord JJ, Rafferty M, FitzGerald DM, Moran J, Cummins R,MacEneaney O, Kay EW, O'Brien CP, Finn SP, Heffron CC, Murphy M, Yela R, Power DG, Regan PJ, McDermott CM, O'Keeffe A, Orosz Z, Donnellan PP, Crown JP, Hennessy BT, Gallagher WM. (2015) 'High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients'. Melanoma Research, 25 (3):189-199.  
Mischak H, Critselis E, Hanash S, Gallagher WM, Vlahou A, Ioannidis JP. (2015) 'Epidemiologic design and analysis for proteomic studies: a primer on -omic technologies'. American Journal of Epidemiology, 181 (9):635-647.  
Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F, Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR, Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirström K,Yakkundi A, McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O'Connor D, Robson T (2015) 'FKBPL: a marker of good prognosis in breast cancer'. Oncotarget, 6 (14):12209-12223.  
Murphy L, Prencipe M, Gallagher WM, Watson RW (2015) 'Commercialized biomarkers: new horizons in prostate cancer diagnostics'. Expert Review of Molecular Diagnostics, 15 (4):491-503.  
Szwej, E. and Devocelle, M. and Kenny, S. and Guzik, M. and O'Connor, S. and Nikodinovic-Runic, J. and Radivojevic, J. and Maslak, V. and Byrne, A.T. and Gallagher, W.M. and Zulian, Q.R. and Zinn, M. and O'Connor, K.E. (2015) 'The chain length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity and structure of anti-cancer peptides'. Journal of Biotechnology, 204 :7-12. Available Online  
Jarzabek MA, Amberger-Murphy V, Callanan JJ, Gao C, Zagozdzon AM, Shiels L, Wang J, Ligon KL, Rich BE, Dicker P, Gallagher WM, Prehn JH, Byrne AT. (2014) 'Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models'. British Journal of Cancer, 111 (12):2275-2286.  
Duffy MJ, Synnott NC, McGowan PM, Crown J, O'Connor D, Gallagher WM. (2014) 'p53 as a target for the treatment of cancer'. Cancer Treatment Reviews, 40 (10):1153-1160.  
Mulrane L, Gallagher WM, O'Connor DP (2014) 'A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer'. Breast Cancer Research, 16 (6).  
Stephen F Madden, Colin Clarke, Britta Stordal, Mark S Carey, Russell Broaddus, William M Gallagher, John Crown, Gordon B Mills and Bryan T Hennessy. (2014) 'OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets'. Molecular Cancer, 13 (241).  
Dr Jana Haase
Haase, J. and Brown, E. (2015) 'Integrating the monoamine, neurotrophin and cytokine hypotheses of depression - A central role for the serotonin transporter?'. Pharmacology and Therapeutics, 147 :1-11. Available Online  
Dr Caroline Herron
Metais, C., Hughes, B and Herron C. (2015) 'Simvastatin increases excitability in the hippocampus via a PI3 kinase-dependent mechanism''. Neuroscience, 291 :279-288.  
Dr Chandralal Hewage
Kenny, O., Brunton, N. P., Walsh, D., Hewage, C. M., McLoughlin, P., Smyth, T. J. (2015) 'Characterisation of Antimicrobial Extracts from Dandelion Root (Taraxacum officinale) Using LC-SPE-NMR'. Phytotherapy Research . Available Online  
Kenny, O. and Brunton, N.P. and Walsh, D. and Hewage, C.M. and Mcloughlin, P. and Smyth, T.J. (2015) 'Characterisation of Antimicrobial Extracts from Dandelion Root (Taraxacum officinale) Using LC-SPE-NMR'. Phytotherapy Research . Available Online  
Kenny, O. and Brunton, N.P. and Walsh, D. and Hewage, C.M. and McLoughlin, P. and Smyth, T.J. (2015) 'Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR'. Phytotherapy Research, 29 (4):526-532. Available Online  
Kenny, O. and Smyth, T.J. and Hewage, C.M. and Brunton, N.P. (2015) 'Quantitative UPLC-MS/MS analysis of chlorogenic acid derivatives in antioxidant fractionates from dandelion (Taraxacum officinale) root'. International Journal of Food Science and Technology, 50 (3):766-773. Available Online  
Dr Breandán Kennedy
Casey, J.P. and McGettigan, P.A. and Healy, F. and Hogg, C. and Reynolds, A. and Kennedy, B.N. and Ennis, S. and Slattery, D. and Lynch, S.A. (2015) 'Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population'. European Journal of Human Genetics, 23 (2):210-217. Available Online  
Yin J, Morrissey ME, Shine L, Kennedy C, Higgins DG, Kennedy BN (2014) 'Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis'. Genomics, 15 (1).  
Professor Therese Kinsella
O'Sullivan AG, Mulvaney EP, Hyland PB and Kinsella BT. (2015) 'Protein kinase C-related Kinase 1 and 2 play an essential role in Thromboxane-mediated Neoplastic Responses in Prostate Cancer'. Oncotarget, 6 (28):26437-26456.  
Reid HM and Kinsella BT. (2015) 'Prostacyclin Receptors: Transcriptional Regulation and Novel Signalling Mechanisms'. Prostaglandins & other lipid mediators, S1098-8823 (15):1-13.  
Eivers SB & Kinsella BT. (2015) 'Regulated Expression of the I Prostanoid Receptor (IP) Gene by Androgens: Combined role for Serum Cholesterol'. FASEB Journal, 29 :619.7-619.7.  
Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) 'Members of the Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-related Responses'. FASEB Journal, 29 :934.4-934.4.  
Professor Jonathan Malthouse
Bergner T, Tabib CR, Winkler A, Stipsits S, Kayer H, Lee J, Malthouse JP, Mayhew S, Müller F, Gruber K, Macheroux P. (2015) 'Structural and biochemical properties of LuxF from Photobacterium leiognathi'. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1854 :1466-1475.  
Cleary JA, Doherty W, Evans P, Malthouse JP. (2015) 'Quantifying tetrahedral adduct formation and stabilization in the cysteine and the serine proteases'. Biochimica et Biophysica Acta - Proteins and Proteomics, 1854 :1382-1391.  
Dr Gethin McBean
McBean, G.J., Aslan, M., Griffiths, H.R., Torrão, R.C. (2015) 'Thiol redox homeostasis in neurodegenerative disease'. Redox Biology, 5 :186-194.  
Dr Margaret McGee
Lavin, Paul T; Mc Gee MM (2015) 'Cyclophilin function in Cancer; lessons from virus replication'. Current Molecular Pharmacology .  
Mc Gee MM (2015) 'Targeting the Mitotic Catastrophe Signaling Pathway in Cancer'. Mediators of Inflammation .  
Dr Hilary McMahon
O'Sullivan J, Comerford E, Rachidi W, Scott M, Hooper N, McMahon H (2015) 'The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11a'. Biochimica et biophysica acta, 1850 (11):2213-2221.  
Dr Tara McMorrow
Slyne J, Slattery C;McMorrow T;Ryan MP (2015) 'New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms'. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30 Suppl 4 :1-7.  
Cassidy H, Slyne J, O'Kelly P, Traynor C, Conlon PJ, Johnston O, Slattery C, Ryan MP, McMorrow T (2015) 'Urinary biomarkers of chronic allograft nephropathy'. Proteomics - Clinical Applications, 9 (5-6):574-585.  
Professor Wim Meijer
Babatunde, AO; Miranda-CasoLuengo, R; Imtiaz, M; Zhao, YQ; Meijer, WG (2015) 'Performance assessment and microbial diversity of two pilot scale multi-stage sub-surface flow constructed wetland systems'. Journal of Environmental Sciences .  
Valero-Rello, A; Hapeshi, A; Anastasi, E; Alvarez, S; Scortti, M; Meijer, WG; MacArthur, I; Vazquez-Boland, J (2015) 'An invertron-like linear plasmid mediates intracellular survival and virulence in bovine isolates of Rhodococcus equi'. Infection and Immunity, 83 (7):2725-2737.  
Coulson, GB; Miranda-CasoLuengo, AA; Miranda-CasoLuengo, R; Wang, X; Oliver, J; Willingham-Lane JM; Meijer, WG; Hondalus, MK (2015) 'Transcriptome reprogramming by plasmid encoded transcriptional regulators is required for host-niche adaptation of a macrophage pathogen'. Infection and Immunity, 83 (8):3137-3145.  
Bedri, Z; Corkery, A; O'Sullivan, JJ; Deering, LA; Demeter, K; Meijer, WG; O'Hare, G; Masterson, B; (2015) 'Evaluating a microbial water quality prediction model for beach management under the revised EU Bathing Water Directive'. Journal of Environmental Management .  
Bedri, Z; O'Sullivan, JJ; Deering, LA; Demeter, K; Masterson, B; Meijer, WG; & O'Hare, G.M.P (2015) 'Assessing the water quality response to an alternative sewage disposal strategy at bathing sites on the east coast of Ireland'. Marine Pollution Bulletin, 91 (1):330-346. Available Online  
Bedri, Z; Corkery, A; O'Sullivan, JJ; Alvarez, MX; Erichsen, AChr, Deering, LA; Demeter, K; O'Hare GMP; Meijer WG; Masterson, B (2014) 'An integrated catchment-coastal modelling system for real-time water quality forecasts'. Environmental Modelling and Software, 61 :458-476.  
Dr Raul Miranda Caso Luengo
Babatunde, AO; Miranda-CasoLuengo, R; Imtiaz, M; Zhao, YQ; Meijer, WG (2015) 'Performance assessment and microbial diversity of two pilot scale multi-stage sub-surface flow constructed wetland systems'. Journal of Environmental Sciences .  
Coulson, GB; Miranda-CasoLuengo, AA; Miranda-CasoLuengo, R; Wang, X; Oliver, J; Willingham-Lane JM; Meijer, WG; Hondalus, MK (2015) 'Transcriptome reprogramming by plasmid encoded transcriptional regulators is required for host-niche adaptation of a macrophage pathogen'. Infection and Immunity, 83 (8):3137-3145.  
Dr Jennifer Mitchell
Kathleen E. Budd, Finola McCoy, Stefan Monecke, Paul Cormican, Jennifer Mitchell, Orla M. Keane (2015) 'Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97'. PLoS ONE .  
Jennifer Mitchell (2014) 'Go with the flow: S aureus and vascular infection'. Blood, 124 (10):1549-1551.  
Dr Cormac Declan Murphy
Quinn, L; Dempsey, R; Casey E; Kane , A; Murphy, C (2015) 'Production of drug metabolites by immobilised Cunninghamella elegans: from screening to scale-up'. Journal of Industrial Microbiology, 42 :799-806.  
Gazzola, G; Habimana, O; Murphy, C; Casey. E (2015) 'Comparison of biomass detachment from two different Pseudomonas spp. biofilms under constant shear conditions'. Biofouling, 31 (1):13-18.  
Murphy, C (2015) 'Drug metabolism in microorganisms'. Biotechnology Letters, 37 :19-28.  
Murphy, C; Sandford, G (2015) 'Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity'. Expert Opinion on Drug Metabolism & Toxicology, 11 :589-599.  
O'Connor,N; Hudson, A; Cobb, S; O'Neil, D; Robertson, J; Duncan V; Murphy, C (2014) 'Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis'. Amino Acids, 46 :2745-2752.  
Dr Keith Murphy
Power, B.J. and O'reilly, G. and Murphy, R. and Murphy, K.J. and Pickering, M. and Jones, J.F.X. (2015) 'Normal nerve striations are altered in the trembler-J mouse, a model of charcot-marie-tooth disease'. Muscle and Nerve, 51 (2):246-252. Available Online  
Dr Kathy O'Boyle
Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O (2014) 'First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models'. Neuropharmacology, 89C :193-203.  
Dr David O'Connell
David J O'Connell, Francesca Baldelli Bombelli, Andrzej Pitek, Marco Monopoli, Dolores Cahill and Kenneth A Dawson (2015) 'Characterization of the bionano interface and mapping extrinsic interactions of the corona of nanomaterials'. Nanoscale .  
Duffy FJ, O'Donovan D, Devocelle M, Moran N, O'Connell DJ, Shields DC (2015) 'Virtual Screening Using Combinatorial Cyclic Peptide Libraries Reveals Protein Interfaces Readily Targetable by Cyclic Peptides'. J CHEM INF MODEL .  
Jan Rosier and David O'Connell (2015) 'Nuances in the Entrepreneurship Training Toolbox'. Nature Biotechnology, 33 :133-135.  
Dawn R. Christiansona, Andrey S. Dobroffb, Bettina Pronetha, Amado J. Zuritad, Ahmad Salameha, Eleonora Dondossolaa, Jun Makinoe, Cristian G. Bologaf, Tracey L. Smith, Virginia J. Yaob, Tiffany L. Calderoneg, David J. O'Connell, Tudor I. Opreaf, Kazunori Kataokai, Dolores J. Cahill, Jeffrey E. Gershenwald, Richard L. Sidmanj, Wadih Arap, and Renata Pasqualini (2015) 'Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis'. PNAS, :1-6.  
Duffy, F.J. and O'Donovan, D. and Devocelle, M. and Moran, N. and O'Connell, D.J. and Shields, D.C. (2015) 'Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides'. Journal of Chemical Information and Modeling, 55 (3):600-613. Available Online  
Dr Darran O'Connor
Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F, Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR, Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirstrm K,Yakkundi A, McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O'Connor D, Robson T (2015) ''FKBPL: a marker of good prognosis in breast cancer'. Oncotarget, 6 (14):12209-12223.  
Finucane, O.M.a and Lyons, C.L.b and Murphy, A.M.c and Reynolds, C.M.d and Klinger, R.e and Healy, N.P.f and Cooke, A.A.g and Coll, R.C.h and McAllan, L.i and Nilaweera, K.N.j and O'Reilly, M.E.k and Tierney, A.C.l and Morine, M.J.m and Alcala-Diaz, J.F.n and Lopez-Miranda, J.o and O'Connor, D.P.p and O'Neill, L.A.q and McGillicuddy, F.C.r and Roche, H.M.s (2015) 'Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity'. Diabetes, 64 (6):2116-2128. Available Online  
Duffy MJ, Synnott NC, McGowan PM, Crown J, O'Connor D, Gallagher WM. (2014) 'p53 as a target for the treatment of cancer'. Cancer Treatment Reviews, 40 :1153-1160.  
Mulrane L, Gallagher WM, O'Connor DP (2014) 'A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer'. Breast Cancer Research, 16 (6).  
Ivers LP, Cummings B, Owolabi F, Welzel K, Klinger R, Saitoh S, O'Connor D, Fujita Y, Scholz D, Itasaki N (2014) 'Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture'. Cancer Cell International, 14 (1).  
Dr John O'Connor
O'Connor JJ (2015) 'Neuroimmunology and synaptic function'. Neuropharmacology, 96 (A):1-3.  
Audrey M. Wall, Gatambwa Mukandala, Nigel H. Greig, John J. O'Connor (2015) 'Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia'. Neuroscience Research, 93 (5):815-829.  
Goutier W, O'Connor JJ. Lowry, JP, McCreary AC (2015) 'The effect of nicotine induced behavioral sensitization on dopamine D1 receptor pharmacology: An in vivo and ex vivo study in the rat'. European Neuropsychopharmacology, 25 (6):933-943.  
Professor Kevin O'Connor
Jelena Radivojevic, Sanja Skaro, Lidija Senerovic, Branka Vasiljevic, Maciej Guzik, Shane T Kenny, Veselin Maslak, Jasmina Nikodinovic-Runic, Kevin E O¿Connor (2015) 'Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds'. Applied Microbiology and Biotechnology, :1-12.  
T Narancic, R Davis, J Nikodinovic-Runic, KE O¿Connor. (2015) 'Recent developments in biocatalysis beyond the laboratory'. Fems Microbiology Letters, 37 (5):943-954.  
Davis R, Duane G, Kenny ST, Cerrone F, Guzik MW, Babu RP, Casey E, O'Connor KE. (2015) 'High cell density cultivation of Pseudomonas putida KT2440 using glucose without the need for oxygen enriched air supply'. Biotechnology and Bioengineering, 112 (4):725-733.  
Santosh K. Choudhari, Federico Cerrone, Trevor Woods, Kieran Joyce, Vincent O Flaherty, Kevin O Connor, Ramesh Babu. (2015) 'Pervaporation separation of butyric acid from aqueous and anaerobic digestion (AD) solutions using PEBA based composite membranes'. Journal of Industrial and Engineering Chemistry, 191 :45-52.  
Cerrone, F. and Davis, R. and Kenny, S.T. and Woods, T. and O'Donovan, A. and Gupta, V.K. and Tuohy, M. and Babu, R.P. and O'Kiely, P. and O'Connor, K. (2015) 'Use of a mannitol rich ensiled grass press juice (EGPJ) as a sole carbon source for polyhydroxyalkanoates (PHAs) production through high cell density cultivation'. Bioresource Technology, 191 :45-52. Available Online  
Szwej, E. and Devocelle, M. and Kenny, S. and Guzik, M. and O'Connor, S. and Nikodinovic-Runic, J. and Radivojevic, J. and Maslak, V. and Byrne, A.T. and Gallagher, W.M. and Zulian, Q.R. and Zinn, M. and O'Connor, K.E. (2015) 'The chain length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity and structure of anti-cancer peptides'. Journal of Biotechnology, 204 :7-12. Available Online  
Professor Jan Rosier
Jan Rosier and David O'Connell (2015) 'Nuances in the Entrepreneurship Training Toolbox'. Nature Biotechnology, 33 :133-135.  
Professor Mike Scott
O'Sullivan J, Comerford E, Rachidi W, Scott M, Hooper N, McMahon H (2015) 'The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11a'. Biochimica et biophysica acta, 1850 (11):2213-2221.  
Professor Dominic Walsh
Adam Cantlon, Carlo Sala Frigerio and Dominic M. Walsh (2015) 'Lessons from a Rare Familial Dementia: Amyloid and Beyond'. Journal of Parkinson's Disease and Alzheimer's Disease, 2 (1).  
Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM (2015) 'C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death'. Journal of Neuroscience, 35 (30):10851-10865.  
Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM (2015) 'The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers'. Journal of Biological Chemistry, 290 (27):16502-16516.  
Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM 3rd, Frosch MP, Walsh DM (2015) 'The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species'. Alzheimer's and Dementia .  
Dr Peadar Ó Gaora
McBryan J, Fagan A, McCartan D, Bane FT, Vareslija D, Cocchiglia S, Byrne C, Bolger JC, McIlroy M, Hudson L, Tibbitts PS, O Gaora P, Hill AD, Young L (2015) 'Transcriptomic profiling of sequential tumours from breast cancer patients provides a global view of metastatic expression changes following endocrine therapy'. Clinical Cancer Research .  
Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P (2015) 'Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells'. British Journal of Pharmacology .  
Maillo V, Ó Gaora P, Forde N, Besenfelder U, Havlicek V, Burns GW, Spencer TE, Gutierrez-Adan A, Lonergan P, Rizos D (2015) 'Oviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?'. Biology of Reproduction, 92 (6).  
Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O (2015) 'Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1'. Prostaglandins and Other Lipid Mediators .  


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Other Journals

Dr Cormac Declan Murphy
Murphy, C; Sandford, G (2015) 'Fluorinated pharmaceuticals: synthesis and opportunities' European Biopharmaceutical Review, :72-74.  
Professor Kevin O'Connor
Margaret Walsh, Kevin O¿Connor, Ramesh Babu, Trevoe Woods, and Shane Kenny (2015) 'Plant Oils and Products of Their Hydrolysis as Substrates for Polyhydroxyalkanoate Synthesis' Chemical and Biochemical engineering quarterly, 29 (2):123-133.  


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Conference Publications

Dr Eugene Dempsey
Eugene Dempsey, Feidhlim Dervin, Patricia B. Maguire (2014) Platelet Derived Exosomes Are Enriched for Specific microRNAs Which Regulate WNT Signalling in Endothelial Cells The American Society of Hematology annual meeting, Moscone Center, San Francisco, 2760 - 2760 Available Online  
Dr Jana Haase
Eric Brown, Robert Schwamborn, Leilani Santos, Martina Gogarty, David Brayden, and Jana Haase (2015) Regulation of serotonin transporter activity in animal models of peripheral inflammation - relevance to inflammation-induced depression 40th Congress of The Federation of European Biochemical Societies (FEBS),  
Jana Haase, Eric Brown, Joanna Grudzinska, Elysian Chow, Sandra Malynn, Heidi Kaastrup Müller, Julia Patzig, Hauke Werner, Zohreh Farsi, Reinhard Jahn, Johannes Zander, Gudrun Ahnert-Hilger (2015) Serotonin transporter associated protein complexes - new insight into transporter activity regulation and trafficking 40th Congress of The Federation of European Biochemical Societies (FEBS),  
Dr Caroline Herron
Blathnaid Hughes and Caroline Herron (2015) Cannabidiol reduces the attenuation of hippocampal Long term Potentiation in models of Alzheimers disease Internatioal Cannabinoid Research Society,  
Dr Breandán Kennedy
Clare T Butler, Adrian Murphy, William M Gallagher, Jacintha O'Sullivan, Breandán Kennedy (2015) Phenotype-based development of novel therapies for the treatment of colorectal cancer Cancer Research,  
Temitope Sasore, Roisin Dunne, Breandan N Kennedy (2015) Can drug combinations targeting PI3K/Akt/mTOR pathway inhibit angiogenesis, inflammation or permeability in human RPE and endothelial cell lines? Investigative Ophthalmology & Visual Science,  
Claire Kilty, Adolfo Lopez-Noriega, Camille Hurley, Neil O'Conner, Alison Reynolds, Cormac Murphy, Fergal O'Brien, Breandan N Kennedy (2015) Sustained Release from Biodegradable Microparticles of Bioactive Cysteinyl Leukotriene Receptor Antagonists for the Treatment of Ocular Neovascularisation Investigative Ophthalmology & Visual Science,  
Conor Daly, Lisa Shine, Eugene Dillon, Theresa Heffernan, Alison Reynolds, David Duffy, Gerard Cagney, Breandan N Kennedy (2015) PHARMACOLOGICAL RESTORATION OF VISUAL FUNCTION IN A BLIND ZEBRAFISH MUTANT FOLLOWING HDAC INHIBITOR (HDACi) TREATMENT Investigative Ophthalmology & Visual Science,  
Stephanie Merrigan, Orla Galvin, Alison Reynolds, Breandan N Kennedy (2015) Vitamin D Receptor Agonists Significantly Attenuate Ocular Developmental Angiogenesis Investigative Ophthalmology & Visual Science,  
Breandan N Kennedy, Yolanda Alvarez, Claire Kilty, Orla Galvin, Clare Butler, Stephanie Merrigan, Temitope Sasore, Carmel McVicar, Alan W Stitt, Alison Reynolds (2015) Phenotype-Based Discovery of Cysteinyl Leukotriene Receptor Antagonists as Novel Inhibitors of Developmental and Pathological Ocular Angiogenesis Investigative Ophthalmology & Visual Science, 5848 - 5848  
Professor Therese Kinsella
Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) Members of the Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-related Responses American Association for Cancer Research, Philadelphia, PA, USA, Presented at American Association for Cancer Research, Philadelphia, PA, USA. April 18 - April 22nd, 2015. Abstract: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015, Abstract #49, Available Online  
Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) Members of the Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-related Responses Experimental Biology 2015, Boston, MA, USA, Presented at Experimental Biology 2015, Boston, MA, USA. March 28 - April 1, 2015. Published in FASEB J. (2015) 29:934.4, Available Online  
Kinsella BT. (2014) Platelets and vascular cells, prostacyclin and thromboxane receptors 5th European Workshop on Lipid Mediators, Presented at the 5th European Workshop on Lipid Mediators. October 23-24th, 2014, University of Istanbul, Congress and Cultural Center, Istanbul, Turkey,  
Professor Jonathan Malthouse
Cleary, J. and Malthouse, J.P.G. (2014) Using 1D 1H-NMR to investigate the mechanism of chymotrypsin UCD Conway Institute Festival of Research, University College Dublin,  


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Other Publications

Dr John O'Connor
O'Connor (2015) Neuroimmunology and Synaptic function. Invited Review Articles.  
Audrey Wall, Gatambwa Mukandala, John J. O'Connor. (2014) Hypoxic pre-conditioning improves the recovery of synaptic transmission in the hippocampus. Published abstracts.  


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