University College Dublin, Ireland

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Professor William Powderly

UCD School of Medicine & Medical Science
UCD Conway Institute
Molecular Medicine Ireland (formerly DMMC)

Professor William Powderly

Professor William Powderly

Research involving Professor Powderly has led to a breakthrough in identifying the most effective initial treatment for HIV. The study, which was documented in the New England Journal of Medicine, confirmed that one of the most frequently prescribed triple-drug combinations for initial HIV-1 infection is the most effective at suppressing HIV. The study also found that a two-drug regimen performed comparably for patients susceptible to severe side effects from nucleoside reverse transcriptase inhibitors (NRTIs) that form part of the three-drug regimen. This is leading to a better evaluation of the treatments currently on the market and a better understanding of their effectiveness and side effectives.

For the 2,000 HIV patients being treated in Irish hospitals and the approximately 400 new patients who are diagnosed each year, this finding is profoundly important, specifically for those who require immediate therapy. Advances in medical research such as Professor Powderly’s, ultimately mean fewer side effects, fewer pills and more effective long term treatment.

Professor Powderly is Principal Investigator for the Dublin HIV Cohort, a project funded by the Health Research Board to study the natural history and complications of HIV in a diverse population of patients infected with the virus.  This study currently includes over 1,000 patients from major Dublin hospitals. His research areas are infections in immuno-compromised hosts especially HIV infection; clinical trials of new antiretroviral agents and of therapies of opportunistic infection; complications of antiretroviral therapy


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