Cancer research activity within SBBS is focused on the identification, mechanistic anchoring and clinical validation of molecular determinants of tumour progression, with a particular interest in biomarker discovery/translation and drug development to facilitate precision therapy.
SBBS cancer researchers are centrally involved in flagship nationally-funded cancer research programmes, for example the SFI-funded strategic research cluster Molecular Therapeutics for Cancer Ireland, and the Irish Cancer Society’s first collaborative cancer research centre, Breast-Predict.
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Research Interests: Model organisms, Xenopus; Aven; apoptosis; cell cycle regulation.
Research Interests: NMR spectroscopy; molecular modelling; peptides; Structural biology; diabetes; antimicrobial; protein; GIP structure; GPCR structure.
Research Interests: Vision and Blindness; Ocular Pharmacology and Genetics; Colorectal Cancer; Vascular Biology; Neurodegeneration; Drug Discovery and Delivery.
Research Interests: Mechanisms of Disease; Cancer; Mitotic Catastrophe; Mitotic Cell death; Genome stability; Peptidyl prolyl isomerases; Cyclophilin A; Bcl-2 proteins.
Research Interests: biotherapeutics; biotechnology; activity of the calcium binding protein secretagogin in neuronal cells; protein networks.
Research Interests: bioinformatics, including gene expression data analysis; genomics.
My research interests are focused on translational prostate cancer epigenetics; understanding the role of epigenomic aberrations in the pathogenesis of prostate cancer and harnessing these aberrations to develop prognostic and predictive biomarkers. My group has a particular interest in studying DNA methylation changes in the prostate gland and in “liquid biopsies” that can act as surrogates for non-invasive tumour detection and monitoring.
Key words: cancer, epigenetics, prostate cancer, DNA methylation, biomarkers, urine, liquid biopsies