The following is a selection of recent publications from the LNR. To see a more comprehensive list, please visit the group's profiles.
Irvine, G. B., El-Agnaf, O. M., Shankar, G. M., Walsh, Dominic M., (2008) 'Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases'. Molecular Medicine, 14 (7-8):451-464. [Details]
Celia Cabaleiro-Lago, Fiona Quinlan-Pluck, Iseult Lynch, Stina Lindan, Aedin M. Minogue, Eva Thulin, Dominic M. Walsh, Kenneth A. Dawson, Sara Linse (2008) Inhibition of amyloid b-protein fibrillation by polymeric nanoparticles. Journal of American Chemical Society in press.
Sean D. O’Shea, Imelda M. Smith, Olive M. McCabe, Michelle M. Cronin, Dominic M. Walsh and William T. O’Connor (2008) Intracerebroventricular administration of amyloid b-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat. Sensors in press
Weiming Xia, Ting Yang, Imelda M. Smith, Yong Shen, MD, Dominic M. Walsh and Dennis J. Selkoe (2008) A specific ELISA for measuring amyloid -protein oligomers in human plasma and the brains of Alzheimer patients. Archieves in Neurology in press.
Neng-Wei Hu, Imelda M. Smith, Roger Anwyl, Dominic M. Walsh and Michael J. Rowan (2008) Soluble amyloid-ß peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain 131: 2414-24
Vicki Betts, Malcolm A. Leissring, Susi Keck, Georgia Dolios, Rong Wang, Dennis J. Selkoe and Dominic M. Walsh (2008) Aggregation and catabolism of disease-associated intra-A mutations: reduced proteolysis of AA21G by neprilysin. Neurobiology of Disease 31: 442-450.
Thomas L. Kukar, Thomas B. Ladd, Maralyssa A. Bann, Patrick C. Fraering, Raj Narlawar, Alfred Welzel, Robert W. Price, Jason Eriksen, Karen Jansen-West, Barbara A. Cottrell, Christophe Verbeeck, Boris Schmidt, Michael S. Wolfe, Abdul Fauq, Dominic M. Walsh, Edward H. Koo, Todd E Golde (2008) Substrate targeting by g-Secretase Modulators. Nature 453: 925-929.
Ganesh M. Shankar, Shaomin Li, Tapan H. Mehta, Amaya Garcia-Munoz, Cindy Lemere, Michael Farrell, Ciaran M. Regan, Dominic M. Walsh, Bernardo L. Sabatini and Dennis J. Selkoe (2008) Amyloid-ß oligomers isolated directly from the brains of Alzheimer disease patients potently impair synaptic structure and plasticity and learned behavior. Nature Medicine 14:837-42.
Igor Klyubin, Vicki Betts, Kaj Blennow, Henrik Zetterberg, Anders Wallin, Cynthia A. Lemere, William K. Cullen, Alfred Welzel, Ying Peng, Thomas Wisniewski, Dennis J. Selkoe, Roger Anwyl, Dominic M. Walsh and Michael J. Rowan (2008) Aß dimers in human cerebrospinal fluid disrupt synaptic plasticity: prevention by systemic passive immunization. Journal of Neuroscience 28:4231-7.
G. Brent Irvine, Omar M. El Agnaf, Ganesh M. Shankar and Dominic M. Walsh (2008) Protein Aggregation in the Brain. Molecular Medicine 14:451-64.
Wesley Farris, Sonja Schütz, John R. Cirrito, Ganesh M. Shankar, Xioayan Sun,Patrick C. May, Ana George, Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, Dennis J. Selkoe (2007) Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy. Amercian Journal of Pathology 171:241-51.
Dominic M. Walsh and Dennis J. Selkoe (2007) A oligomers – a decade of discovery. Journal of Neurochemistry 101:1172-1180.
Ganesh M. Shankar, Matthew Townsend, Dominic M. Walsh, Dennis J. Selkoe and Bernardo L. Sabatini (2007) Natural oligomers of the Alzheimer amyloid-b protein lower dendritic spine density and synapse number in hippocampus. Journal of Neuroscience 27:2866-75.
Dominic M. Walsh, Aedín M. Minogue, Carlo Sala Frigerio, Julia V. Fadeeva, Wilma Wasco and Dennis J. Selkoe (2007) The APP family of proteins: similarities and differences. Biochemical Society Transactions 35:46-50.
Shankar, G. M., Li, S. M., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., Selkoe, D. J., (2008) 'Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory'. Nature, 14 (8):837-842. [Details]
Wesley Farris, Sonja Schütz, John R. Cirrito, Ganesh M. Shankar, Xioayan Sun,Patrick C. May, Ana George, Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, Dennis J. Selkoe (2007) 'Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy'. American Journal of Pathology, 171 (1):241-251. [Details]
Dominic M. Walsh and Dennis J. Selkoe (2007) 'Abeta oligomers - a decade of discovery'. Journal of Neurochemistry, 101 :1172-1180. [Details]
Laboratory for Neurodegenerative Research