In keeping with its strong reputation for publications, inventions and patents, SBBS academics have made impressive achievements to date this year.
Patents Filed & Invention Disclosures January - August 2008| Academic | Patent Filed |
|---|---|
| Liam Gallagher | Method and system for image analysis |
| Ciaran Regan | Alternatively transcribed genes associated with Memory Consolidation |
| Alternatively transcribed genes associated with Schizophrenia | |
| Dr. Orina Belton | Nitrosylated Conjugated Linoleic Acids |
| Dr. Annette Byrne | Compositions and methods for the control of mammary cell number |
| Dr. Kevin O'Connor | The conversion of a mixture BTEX compounds by defined mixed cultures to medium chain length polyhydroxyalkanoate |
| Method for producing Polyhydroxyalkanoate (PET to PHA) | |
| Pseudomonas putida styrene monooxygenase variants | |
| Method for producing Polyhydroxyalkanoate (PET to PHA) | |
| Prof. Ciaran Regan | Cognition TxP (Alternatively transcribed Genes Associated with Memory Consolidation (ANRG) |
| Schizo TxP (Alternatively Transcribed Genes Associated with Schizophrenia (ANRG) | |
| Meparfynol (PSYCHOSCREEN) | |
| Captodiamine (PSYCHOSCREEN) |
| Academic | Invention Disclosed |
|---|---|
| Breandan Kennedy | Novel Anti-angiogenic drugs |
| Alejandro Merino | Methods for the use of domains or subdomains for immobilisation of fusion proteins |
| Therese Kinsella | Regulation of the Human Prostacyclin Receptor by Intestinal and Kidney-enriched PDZ protein (IKEPP) |
| Regulation of the InaD-like (Drosophila) Protein (INADL). | |
| Regulation of the Multi-PDZ domain protein 1 (MUPP1). | |
| Regulation of the Human Prostacyclin Receptor by PDZ Domain Containing Protein 1 (PDZK1). | |
| Interaction between the Human Thromboxane A 2 Receptor and Anglo-Associated Migratory Cell Protein | |
| Cormac Murphy | Streptomyces globosus IMD 2703: a novel strain that produces an anti-MRSA antibiotic |
| Jens Erik Nielsen | PEAT_SA |
| Dr.. Alfonso Blanco | Flow Cytometer Simulator |
| Prof. Therese Kinsella | Regulation of the human thromboxane A2 Receptor Gene by Sp1, Egr1, NF-E2, GATA-1 and Ets-1 in Megakaryocytes |
| The Wilms' Tumour Suppressor Protein WT1 acts as a key Transcriptional Repressor of the Human Thromboxane A2 Receptor Gene in Megakaryocytes | |
| Induction of human Thromboxane A2 Receptor a Expression during Megakaryocytic Differentiation: A novel role for transcription factors WT!, Egr1 Sp1 | |
| Dr. David McLaughlin | Identification of a Multineurotransmitter phenotype in foetal human self renewing cells derived from subcultures of amniotic fluid for use in High Throughput Screening |
| Induction of a homogeneous Cholinergic neurotransmitter phenotype in cells derived from subcultures of human amniotic fluid | |
| Identification of a homogeneous Serotonergic neurotransmitter phenotype in cells derived from subcultures of human amniotic fluid | |
| Dermal cells from human amniotic Mesenchymal stem cells and their use in autologous tissue engineering to correct congenital defects | |
| Dr. Kevin O' Connor | Hydroxyalkanoyl-peptide as an anti-cancer agent |
| Cellulose to Polyhydroxyalkanoate (PHA) |
- Murphy, C. (2009) 'Halogenated Organic Compounds - Carbon-Halogen Bond Formation' In: Timmis KN (eds). Microbiology of Hydrocarbons, Oils, Lipids and Derived Compounds. Heidelberg: Springer. [Details]
- Smith, C.J., B.S. Danilowicz, W.G. Meijer (2009) 'Bacteria associated with the mucus layer of Merlangius merlangus (whiting) as biological tags to determine harvest location'. Canadian Journal of Fisheries and Aquatic Science, . [Details]
- Bane FT, Bannon JH, Pennington SR, Campiani G, Williams DC, Zisterer DM, Mc Gee MM, (2009) 'The microtubule-targeting agents, PBOX-6 and paclitaxel, induce nuclear-cytoplasmic redistribution of the peptidyl prolyl isomerases, cyclophilin A and pin1, in malignant haematopoietic cells'. Journal of Pharmacology and Experimental Therapeutics, . [DOI Link] [Details]
- Elizebeth C. Turner & B. Therese Kinsella. (2009) 'Transcripional Regulation of the Human Prostacyclin Receptor Gene is Dependent on Sp1, Pu.1 and Oct1 in Megakaryocytes and Endothelial Cells'. Journal of Molecular Biology, 386 :579-597. [Details]
- Neuweiler, H., Sharpe, T. D., Johnson, C. M., Teufel, D. P., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier limited folding of BBL. 2. Mechanistic Insights from kinetics of folding monitored by independent tryptophan probes'. Journal of Molecular Biology, . [Details]
- Arbely, A., Rutherford, T. J., Sharpe, T. D., Ferguson, N. & Fersht, A. R. (2009) 'Downhill versus barrier-limited folding. 1. Energetic and structural basis for the perturbation of the protein BBL on protonation of a histidine of unusually low pKa'. Journal of Molecular Biology, . [Details]
- Rossignol T, Ding C, Guida A, d'Enfert C, Higgins DG, Butler G. (2009) 'Correlation Between Biofilm Formation and the Hypoxic Response in Candida parapsilosis'. Eukaryotic Cell, . [Details]
- McBean GJ, Murphy A, Vines A, (2009) 'Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx'. Biochimica et biophysica acta, 1788 :551-558. [DOI Link] [Details]
- Blacque OE, Cevik S, Kaplan OI (2008) 'Intraflagellar transport: from molecular characterisation to mechanism'. Frontiers in Bioscience, 13 :2633-2652. [Details]
Roetzer A, Gregori C, Jennings AM, Quintin J, Ferrandon D, Butler G, Kuchler K, Ammerer G, Schüller C. (2008) 'Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors'. Molecular Microbiology, . [Details]
Butler G, Fitzpatrick DA, Logue ME, (2008) 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'. BMC Evolutionary Biology, 8 (1). [Details]
Caffrey, P., Aparicio, J. F., Malpartida, F., Zotchev, S. B. (2008) 'Biosynthetic engineering of polyene macrolides for generation of improved antifungal and antiparasitic agents'. Current Topics in Medicinal Chemistry, . [Details]
Power, P., Dunne, T., Murphy, B., Nic Lochlainn, L., Rai, D., Borissow, C., Rawlings, B., and Caffrey, P. (2008) 'Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics'. Chemistry & Biology, 15 :78-86. [Details]
Yuxiang Huang, Mei Yee Choi, Shannon Wing Ngor Au, Deborah Man Yee Au, Veronica Min Sien Lam, Paul C Engel. (2008) 'Defective protein folding, a mechanism underlying two clinically different human glucose 6-phosphate dehydrogenase variants, G6PDPlymouth and G6PDMahidol '. Molecular Genetics and Metabolism, . [Details]
Pickering M, Pickering BW,Murphy KJ, O¿Connor JJ (2008) 'Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunohistochemical labeling'. Journal of Neuroscience Methods, . [Details]
Søndergaard CR, McIntosh LP, Pollastri G, Nielsen JE (2008) 'Determination of electrostatic interaction energies and protonation state populations in enzyme active sites'. Journal of Molecular Biology, 376 (1):269-287. [Details]
Hogan N, O'Boyle KM, Hinkle PM, Kelly JA. (2008) 'A novel TRH analog, Glp-Asn-Pro-d-Tyr-d-TrpNH(2), binds to [(3)H][3-Me-His(2)]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2'. NEUROSCIENCE LETTERS, . [Details]
Zhou, Y., Zhao, Y., O¿Boyle K.M., Murphu, P.V. (2008) 'Hybrid angioenesis inhibitors: synthesis and biological evaluation of bifunctionl cokmpounds based on 1-deoxynojirmycin and aryl-1,2,3-triazole.'. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, . [Details]
Holland, L. M., O'Donnell, S. T., Ryjenkov, D.A., Gomelsky, L., Slater, S.R., Fey, P.D., Gomelsky, M. and O'Gara, J.P. (2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of c-di-GMP'. Journal of Bacteriology, In Press . [Details]
O'Neill, E., Pozzi, C., Houston, P., Humphreys, H., Robinson, D.A., Loughman, A., Foster, T.J. and O'Gara J.P. (2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'. JOURNAL OF BACTERIOLOGY, 190 (11):3835-3850. [Details]
Stevens, N., Tharmabala, M., Dillane, T., Greene, C., O'Gara, J. P., Humphreys, H. (2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis '. CLINICAL MICROBIOLOGY AND INFECTION, In Press . [Details]
Harald Hampel, Yong Shen, Dominic M. Walsh, Paul Aisen, Les Shaw, Henrik Zetterberg, John Trojanowski, and Kaj Blennow (2008) Biological markers of β-amyloid related mechanisms in Alzheimer’s Disease. Nature Neuroscience Reviews in press.
Neng-Wei Hu, Imelda M. Smith, Roger Anwyl, Dominic M. Walsh and Michael J. Rowan (2008) Soluble amyloid-ß peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain 131: 2414-24
Weiming Xia, Ting Yang, Imelda M. Smith, Yong Shen, MD, Dominic M. Walsh and Dennis J. Selkoe (2008) A specific ELISA for measuring amyloid b-protein oligomers in human plasma and the brains of Alzheimer patients. Archieves in Neurology in press.
Sean D. O’Shea, Imelda M. Smith, Olive M. McCabe, Michelle M. Cronin, Dominic M. Walsh and William T. O’Connor (2008) Intracerebroventricular administration of amyloid b-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat. Sensors in press.
Vicki Betts, Malcolm A. Leissring, Susi Keck, Georgia
Thomas L. Kukar, Thomas B. Ladd, Maralyssa A. Bann, Patrick C. Fraering, Raj Narlawar, Alfred Welzel, Robert W. Price, Jason Eriksen, Karen Jansen-West, Barbara A. Cottrell, Christophe Verbeeck, Boris Schmidt, Michael S. Wolfe, Abdul Fauq, Dominic M. Walsh, Edward H. Koo, Todd E Golde (2008) Substrate targeting by g-Secretase Modulators. Nature 453: 925-929.
Ganesh M. Shankar, Shaomin Li, Tapan H. Mehta, Amaya Garcia-Munoz, Cindy Lemere, Michael Farrell, Ciaran M. Regan, Dominic M. Walsh, Bernardo L. Sabatini and Dennis J. Selkoe (2008) Amyloid-ß oligomers isolated directly from the brains of Alzheimer disease patients potently impair synaptic structure and plasticity and learned behavior. Nature Medicine 14:837-42.
Igor Klyubin, Vicki Betts, Kaj Blennow, Henrik Zetterberg, Anders Wallin, Cynthia A. Lemere, William K. Cullen, Alfred Welzel, Ying Peng, Thomas Wisniewski, Dennis J. Selkoe, Roger Anwyl, Dominic M. Walsh and Michael J. Rowan (2008) Aß dimers in human cerebrospinal fluid disrupt synaptic plasticity: prevention by systemic passive immunization. Journal of Neuroscience 28:4231-7.
G. Brent Irvine, Omar M. El Agnaf, Ganesh M. Shankar and Dominic M. Walsh (2008) Protein Aggregation in the Brain. Molecular Medicine 14:451-64.
- Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states. Schmid AW, Freir DB, Herron CE. Brain Res. 2008 Mar 4;1197:135-42.
- Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells. Da Silva N, Herron CE, Stevens K, Jollimore CA, Barnes S, Kelly ME. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3065-73.
'Lab Skills: Three Places at Once' by Marco Monopoli