Dr Breandán Kennedy BSc PhD
Contact Details
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Biography:
| ‘Principal Investigator’ 2003-present; UNIVERSITY COLLEGE DUBLIN: College Lecturer in School of Biomolecular & Biomedical Sciences, Career-track Investigator, Conway Institute, ‘Postdoctoral Fellow’ 2000-2003: UNIVERSITY OF WASHINGTON, SEATTLE, USA: Senior fellow in Prof. James Hurley’s lab. Projects analysed eye development using mutant zebrafish and investigated cone photoreceptor function using transgenic zebrafish. 1999-2000, UNIVERSITY OF NOTRE DAME, INDIANA, USA: Postdoctoral fellow in Prof. David Hyde’s lab. Projects include characterization of promoters directing rod photoreceptor-specific expression in transgenic zebrafish. ‘Graduate Student’ 1994-1998, W. ALTON JONES CELL SCIENCE CENTER, NEW YORK, USA: Ph.D. thesis research under supervision of Dr. John Crabb. Studies investigated the regulation of CRALBP transcription, targeted disruption of the mouse CRALBP gene, and identification and analysis of a mutation in CRALBP segregating with retinitis pigmentosa. |
Research Interests
| Our current research interests are to utilise zebrafish to identify genes responsible for survival and function of cone photoreceptors, and to generate zebrafish models of cone photoreceptor disease that can be incorporated into drug screens. |
Research Projects
| Sponsor : University College Dublin (UCD) Title : Drug Modulators of Vision Start Date / End Date : 01-MAY-11 / 31-OCT-12 |
| Sponsor : Enterprise Ireland (EI) Title : Small molecule anti-angiogenics for retinal therapy (SMART) Start Date / End Date : 01-DEC-09 / 30-NOV-10 |
| Sponsor : Science Foundation Ireland (SFI) Title : Defining the targets of RX3, an essential gene for eye development Start Date / End Date : 01-SEP-08 / 31-AUG-11 |
| Sponsor : Fighting Blindness Title : Directing retinal stem cells to become functionally integrated cone photoreceptors in Host retinas Start Date / End Date : 01-JUN-07 / 01-JUN-11 |
| Sponsor : Science Foundation Ireland (SFI) Title : Applying Transgenic Zebrafish Technology to Characterize In Vivo the Molecular Regulators of Cone Photoreceptor Specification Start Date / End Date : 01-AUG-05 / 31-JAN-09 |
| Sponsor : Science Foundation Ireland (SFI) Title : Characterising Regulators of Cone Photoreceptor Gene Expression Start Date / End Date : 01-MAY-05 / 24-JUL-05 |
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| Sponsor : American Health Assistance Foundation (AHAF) Title : Novel Cone-specific genes - Therapeutic targets for MD Start Date / End Date : 01-APR-05 / 30-SEP-07 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Genome - Wide Screens for Determinants of Cone Photoreceptor Function Start Date / End Date : 01-SEP-04 / 30-AUG-08 |
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| Sponsor : Health Research Board (HRB) Title : In Vivo Models of Human Blindness Characterised by Cone-Rod Dystrophy Start Date / End Date : 15-OCT-03 / 14-OCT-06 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Identification and Characterisation of Muscular regulators of Circadian Rhythms Start Date / End Date : 01-SEP-06 / 28-FEB-10 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Genetic screens for cone photoreceptor determinants Start Date / End Date : 18-MAY-06 / 28-AUG-08 |
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| Sponsor : Science Foundation Ireland (SFI) Title : Identification and characterisation of genetic determinants of retinal vasculature using zebrafish Start Date / End Date : 01-SEP-06 / 28-FEB-10 |
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| Sponsor : Health Research Board (HRB) Title : Applying zebrafish to identify and characterise retinal vasculature development Start Date / End Date : 01-JUL-06 / 31-AUG-09 |
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| Sponsor : Health Research Board (HRB) Title : CRALBP function in vision and circadian rhythms Start Date / End Date : 01-OCT-06 / 31-DEC-09 |
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Book Chapters
| Collery, R.F., Cederlund, M.L., Smyth, V.A. and Kennedy, B.N.; (2006) 'Applying Transgenic Zebrafish Technology To Study The Retina' In: Hollyfield J.G., Anderson, R.E., and La Vail M.M (eds). Advances in Experimental Medicine and Biology. New York: Springer. [Details] |
| Kennedy, B.N., Saari, J.C., and Crabb, J.W.; (1999) 'CRALBP and inherited retinal degeneration' In: Hollyfield J.G., Anderson, R.E., and La Vail (eds). Retinal Degenerative Disease and Experimental Therapy (Plenum, NY). [Details] |
Peer Reviewed Journals
| Morrissey ME, Shelton S, Brockerhoff SE, Hurley JB, Kennedy BN; (2011) 'PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors'. BMC Developmental Biology, 11 . [DOI] [Details] |
| Cederlund ML, Morrissey ME, Baden T, Scholz D, Vendrell V, Lagnado L, Connaughton VP, Kennedy BN.; (2011) 'Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells'. Investigative Ophtalmology and Visual Science, 52 (3):1613-1621. [Details] |
| Cederlund ML, Vendrell V, Morrissey ME, Yin J, Gaora PÓ, Smyth VA, Higgins DG, Kennedy BN.; (2011) 'mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation'. Developmental dynamics : an official publication of the American Association of Anatomists, 240 (4):745-754. [Details] |
| Atzei P, Yang F, Collery R, Kennedy BN, Moynagh PN; (2010) 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'. Gene expression patterns : GEP, 10 (4-5):199-206. [DOI] [Details] |
| Kennedy BN, Collery RF, ; (2010) 'Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish'. Advances in Experimental Medical Biology, 664 :55-61. [DOI] [Details] |
| Higgins DG, Yin J, McLoughlin S, Jeffery IB, Glaviano A, Kennedy B, ; (2010) 'Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data'. BMC Genomics, 11 . [DOI] [Details] | |||||||||
| Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN, ; (2010) 'Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy'. Disease models & mechanisms, 3 (3-4):236-245. [DOI] [Details] | |||||||||
| Kennedy BN, Alvarez Y, Astudillo O, Jensen L, Reynolds AL, Waghorne N, Brazil DP, Cao Y, O'Connor JJ, ; (2009) 'Selective inhibition of retinal angiogenesis by targeting PI3 kinase'. PLoS ONE, 4 (11). [DOI] [Details] | |||||||||
| Malicki, J and Kennedy B.N; (2009) 'What drives cell morphogenesis - a look inside the vertebrate photoreceptor. '. Developmental dynamics : an official publication of the American Association of Anatomists, . [Details] | |||||||||
| Kennedy BN, Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC, ; (2008) 'DUPLICATION AND DIVERGENCE OF ZEBRAFISH CRALBP GENES UNCOVERS A NOVEL ROLE FOR RPE- AND MUELLER-CRALBP IN CONE VISION'. Invest Ophthalmol Vis Sci, . [DOI] [Details] | |||||||||
| Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O¿Donoghue D, Sheahan K, Leahy D, Mulcahy H, O¿Sullivan J; (2008) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. CANCER LETT, . [Details] | |||||||||
| Kennedy, BN, Alvarez, Y, Brockerhoff, SE, Stearns, GW, Sapetto-Rebow, B, Taylor, MR, Hurley, JB, ; (2007) 'Identification of a zebrafish cone photoreceptor - Specific promoter and genetic rescue of achromatopsia in the nof mutant'. Investigative Ophthalmology &Amp; Visual Science, 48 :522-529. [Details] | |||||||||
| Smyth VA, Di Lorenzo D, Kennedy BN. ; (2008) 'A novel, evolutionary conserved enhancer of cone photoreceptor-specific expression'. JOURNAL OF BIOLOGICAL CHEMISTRY, . [Details] | |||||||||
| Alvarez Y, Cederlund ML, Cottell DC, Bill BR, Ekker SC, Torres-Vazquez J, Weinstein BM, Hyde DR, Vihtelic TS, Kennedy BN; (2007) 'Genetic determinants of hyaloid and retinal vasculature in zebrafish'. BMC Developmental Biology, 7 (1). [Details] | |||||||||
| Kennedy, B.N.; Yolanda Alvarez; Brockerhoff, S.E.; Stearns, G.; Sapetto-Rebow, B., Taylor, M.R.; and Hurley, J.B.; (2007) 'Identification Of A Zebrafish Cone-Specific Promoter And Genetic Rescue Of Achromatopsia In The nof Mutant'. Invest. Ophth. Vis. Sci, (48):522-529. [Details] | |||||||||
| Kennedy, B. N., Stearns, G. W., Smyth, V. A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J. B., and Brockerhoff, S. E.; (2004) 'Zebrafish rx3 and mab21l2 are Required During Eye Morphogenesis'. Developmental Biology, 270 :336-349. [Details] | |||||||||
| Brockerhoff, S.E., Rieke, F., Matthews, H.R., Cilluffo, M.C., Fain, G.L., Taylor, M.R., Kennedy, B.N, Irina Ankoudinova, I., Xiao, M., Niemi, G.A., Tucker, C.L. and Hurley, J.B.; (2003) 'Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and a suppression of current in cones from the zebrafish mutant nof'. Journal of Neuroscience, 23 :470-480. [Details] | |||||||||
| Kennedy, B.N., Li, C., Ortego, J., Coca-Prados, M., Sarthy, V.P. and Crabb, J.W.; (2003) 'CRALBP Transcriptional Regulation in Ciliary Epithelial, Müller and Retinal Pigment Epithelial Cells'. Experimental Eye Research, (76):257-260. [Details] | |||||||||
| Kennedy, B.N., Vihtelic, T.S., Checkley, L, Vaughan, K.T. and Hyde D.; (2001) 'Isolation of a Zebrafish Rod Opsin Promoter to Generate a Transgenic Zebrafish Line Expressing EGFP in Rod Photoreceptors'. Journal of Biological Chemistry, 276 :14037-14043. [Details] | |||||||||
| Saari, J.C., Nawrot, M., Kennedy, B.N., Garwin, G.G., Hurley, J.B., Huang, J., Possin, D.E. and Crabb, J.W.; (2001) 'Visual Cycle Impairment in the Cellular Retinaldehyde-Binding Protein (CRALBP) Knockout Mice Results in Delayed Dark Adaptation'. Neuron, 29 :739-748. [Details] | |||||||||
| Kennedy, B.N., Goldflam, S., Chang, M.A., Campochiaro, P.A., Davis, A.A., Zack, D.J., and Crabb, J.W.; (1998) 'Transcriptional regulation of the human gene encoding cellular retinaldehyde-binding protein'. Journal of Biological Chemistry, 273 :5591-5598. [Details] | |||||||||
| Sarthy, V., Brodjian, S., Dutt, K., Kennedy, B.N, French, R., and Crabb, J.; (1998) 'Establishment and characterization of a retinal Müller cell line'. IOVS, 39 :212-216. [Details] | |||||||||
| Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W; (1998) 'Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein'. Molecular Vision, 4 . [Details] | |||||||||
| Maw, M.A., Kennedy, B.N., Knight, A., Bridges, R., Roth, K., Mani, E., Mukkadan, J., Nancarrow, D., Crabb, J.W., and Denton, M.J.; (1997) 'R150Q mutation of cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa'. Nature Genetics, 17 :198-200. [Details] | |||||||||
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Conference Publications
| Atzei, P., Maguire, P. B., Kennedy, B. N., Moynagh, P. N., ; (2008) Journal of Neuroimmunology Cactin, a novel regulator of TLR signalling pathways , pp.162-162 [Details] |
Abstract
| Y Alvarez, E Breen, B Bill, J Torrez-Vazquez, T Vihtelic and B.N. Kennedy; (2006) Zebrafish: A Novel Model to Characterise Genetic Determinants of Retinal Vasculature. Abstract [Details] |
| RF Collery, ML Cederlund and BN Kennedy; (2006) Transgenic Expression of Human RetGC-1 in Zebrafish Cone Photoreceptors. Abstract [Details] |
| Smyth, V.A.; Heffernan, T.A.; Di Lorenzo, D.; Kennedy, B.N; (2006) A Novel 20 bp Enhancer Region Controls Cone-specific Expression. Abstract [Details] |
| M. Cederlund, M. Ader, B. Sapetto-Rebow, B.N. Kennedy; (2006) Regulation and function of Mab21l1 and `Mab21l2 genes. Abstract [Details] |
| Y. Alvarez, E. Breen, B. Bill, J. Torres-Vazquez, T. Vihtelic and B.N. Kennedy; (2006) Zebrafish: A Novel In Vivo Model To Identify And Characterise Genetic Determinants Of Retinal Vasculature. Abstract [Details] |
| Smyth, V.A.; Heffernan, T.A.; Di Lorenzo, D.; Kennedy, B.N.; (2006) Characterisation of an Enhancer within the 5' flanking region of the Zebrafish Cone Transducin -subunit. Abstract [Details] | |||||||||
| Cederlund M, Sapetto-Rebow B, O'Callaghan L, Kennedy B.N.; (2006) Regulation and function of zebrafish mab21l1 and mab21l2 genes. Abstract [Details] | |||||||||
| M.C. Cederlund, R.F. Collery, & B.N. Kennedy; (2005) Generating transgenic zebrafish expressing human RetGC-1. Abstract [Details] | |||||||||
| Y. Alvarez, U. Fearon, D. Veale & B.N. Kennedy; (2005) Characterisation Of The Zebrafish Retinal Vasculature. Abstract [Details] | |||||||||
| B.N. Kennedy Y. Alvarez, Cederlund, M., Collery, R. &. Smyth, V.; (2005) Genetic Determinants of cone photoreceptor development and function. Abstract [Details] | |||||||||
| Kennedy, B.N.; Collery, Ross; Cederlund, Maria; Hurley, James and Brockerhoff, Susan.; (2004) Determinants Of Cone Photoreceptor Function And Survival. Abstract [Details] | |||||||||
| Kennedy, B.N., Bhattacharya, S, Crabb, J.S., Bonilha, V.L. and Crabb J.W.; (2004) Preliminary In Vivo Analysis of CRALBP Transcriptional Regulation. Abstract [Details] | |||||||||
| Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E; (2003) Rx3 is required for eye development. Abstract [Details] | |||||||||
| Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E; (2002) Visual and Photoneuroendocrine System Development in eym and TG(TCP-EGFP). Abstract [Details] | |||||||||
| Kennedy, B.N., Shelton, S., Brockerhoff, S. and Hurley, J.; (2001) Gene regulation and function in zebrafish cone photoreceptors. Abstract [Details] | |||||||||
| Kennedy, B.N., Shelton, S., Brockerhoff, S. and Hurley, J.; (2001) Gene regulation and function in zebrafish cone photoreceptors. Abstract [Details] | |||||||||
| Saari, J.C., Nawrot, M., Kennedy, B.N., Hurley, J.B., Garwin G.G., Huang, J., and Crabb, J.W.; (2000) CRALBP is required for a normal rate of 11-cis-retinal synthesis. Abstract [Details] | |||||||||
| Kennedy, B.N., Vihtelic, T.S., Checkley, L. and Hyde, D.R.; (2000) Retina-specific transgene expression in zebrafish. Abstract [Details] | |||||||||
| Kennedy, B.N., Checkley, L., Vihtelic, T.S., and Hyde, D.R; (1999) Cloning the zebrafish genes for rod and ultraviolet opsin. Abstract [Details] | |||||||||
| Hyde, D.R., Kennedy, B.N., Milligan, S.C., Elagina, R,B., Besharse, J.C.; (1999) Expression of dominant RdgB transgenes in Drosophila and Xenopus. Abstract [Details] | |||||||||
| Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W.; (1998) Characterization of the mouse CRALBP gene. Abstract [Details] | |||||||||
| Ortego, J., Kennedy, B.N., Crabb, J.W. and Coca-Prados,; (1998) CRALBP gene regulation in ciliary epithelial cells. Abstract [Details] | |||||||||
| Brodjian, S., Kennedy, B.N., Crabb, J.W. and Sarthy, V.; (1997) Regulation of the cellular retinaldehyde-binding protein (CRALBP) gene in Müller cells. Abstract [Details] | |||||||||
| Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W.; (1997) Comparison of the promoter regions of the mouse and human cellular retinaldehyde-binding protein (CRALBP) genes. Abstract [Details] | |||||||||
| Kennedy, B.N., Maw, M.A., Hulmes, J.D., Knight, A., Bridges, R., Roth, K., Mani, E., Mukkadan, J., Nancarrow, D., Denton, M.J. and Crabb, J.W; (1997) Autosomal recessive retinitis pigmentosa: characterization of a recombinant CRALBP mutant. Abstract [Details] | |||||||||
| Kennedy, B.N., Chang, M.A., Campochiaro, P., Zack, D.J. and Crabb, J.W.; (1996) Potential regulators of CRALBP gene expression. Abstract [Details] | |||||||||
| Kennedy, B.N., Goldflam, S., Chang, M.A., Hacket, S., Campochiaro, P., Davis, A., Zack, D.J., and Crabb, J.W.; (1995) Promoter analysis of the human CRALBP gene. Abstract [Details] | |||||||||
| Chang, M.A., Kennedy, B.N., Crabb, J.W., Hackett, S., Campochiaro, P., and Zack, D.J.,; (1995) Mobility shift assay of human CRALBP promoter. Abstract [Details] | |||||||||
| Saari, J.C., Huang, J., Champer, R.J., Kennedy, B.N., Goldflam, S., and Crabb, J.W.; (1995) Cloning of the mouse gene encoding cellular retinaldehyde-binding protein (CRALBP). Abstract [Details] | |||||||||
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Published abstracts
| B.N. Kennedy, R.F. Collery, J.M. Finnegan.; (2005) Characterisation of zebrafish CRALBP orthologues. Published abstracts [Details] |
| V.A. Smyth, B.N. Kennedy.; (2005) Identification of an enhancer within the 5 flanking region of the ConeTransducin á-subunit. Published abstracts [Details] |
Honours and Awards
| Year: 1993. Title: Ph.D. scholarship from W. Alton Jones Cell Science Center |
| Year: 1999. Title: Postdoctoral fellowship from the Keck Center for Transgene Research |
| Year: 2000. Title: Travel award to 4th International Zebrafish Development & Genetics Meeting, CSH, NY |
| Year: 2000. Title: Postdoctoral fellowship from Howard Hughes Medical Institute |
| Year: 2004. Title: Presidents Research Award |
| Year: 2004. Title: National Eye Institute ¿Young Investigator Travel Award¿ to XIth International Symposium on Retinal Degeneration (RD2004), Perth, Australia |
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Associations
| Association: British Pharmacological Society, Function/Role: |
| Association: Association for Research in Vision and Ophthalmology, Function/Role: * |
Conference Contributions
| 2003, Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E.; (2003) Rx3 is required for eye development. . [Poster Presentation], 3rd European Conference on Zebrafish & Medaka Development and Genetics, Paris , 11-JUN-03 - 14-JUN-03. |
| Kennedy, BN; (2004) Fishing for determinants of cone photoreceptor function. [Invited Oral Presentation], Centre for Integrative Biology Symposium, Dublin , 19-FEB-04 - 19-FEB-04. |
| 1Kennedy, Breandan; 1Collery, Ross; 1Cederlund, Maria; 2Hurley, James and 2Brockerhoff, Susan.; (2004) DETERMINANTS OF CONE PHOTORECEPTOR FUNCTION AND SURVIVAL . [Invited Oral Presentation], XIth International Conference on Retinal Degeneration, Perth, Australia , 23-AUG-04 - 28-AUG-04. |
| Kennedy, Breandan N; (2004) Zebrafish:A Model Organism for Retinal Research . [Invited Oral Presentation], The Fighting Blindness Science Forum, Dublin , 23-SEP-04 - 24-SEP-04. |
| Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E.; (2002) Visual and Photoneuroendocrine System Development in eym and TG(TaCP-EGFP). [Invited Oral Presentation], 5th International Conference on Zebrafish Development and Genetics, Madison, WI , 12-JUN-02 - 16-JUN-02. |
Committees
| Committee : MRC Grant Reviewer 2010 |
| Committee : MRC Grant Reviewer 2011 |
| Committee : DCCR Ophthalmology Group |
Employment
| Employer: University College Dublin. Position: College Lecturer |
| Employer: University of Washington, Seattle Position: Senior Fellow |
| Employer: University of Notre Dame, Indiana Position: Postdoctoral Fellow |
| Employer: University College Dublin Position: Ph.D |
Education
| Year 1999 Institution: University College Dublin Qualification: PhD Subject: |
| Year 1998 Institution: University College Dublin Qualification: PhD Subject: --none-- |
| Year 1993 Institution: University College Dublin Qualification: BSc Subject: |
Reviews
| Bmc Developmental Biology: Reviewer. |
Internal Collaborators
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External Collaborators
| Dr. Susan Brockerhoff Prof. John Crabb Prof. James Hurley Prof. Jack Saari |
Teaching Interests
Recent Postgraduates
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Current Postgraduate Students
| Sudhakar Deeti, Master of Science (MSc) - Thesis Supervisor |
| Theresa Heffernan, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Beata Sapetto-Rebow, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Lisa Shine, Doctor of Philosophy (PhD) - Thesis Supervisor |
Modules Taught
| 201100 BIOC40160 Biochemistry: Drug Develop & Clinical Trials |
| 201000 PHAR40130 Pharmacology: Emerging Therapies |
| 200800 PHAR10010 Pharmacology: Drug Discovery |
| 200800 PHAR20010 Pharmacology: Principles of Pharmacology |
| 200900 PHAR40040 Pharmacology: Emerging therapies |